As Director of the Newborn Screening Centre at National Taiwan University Hospital, Dr Yin-Hsiu (Nancy) Chien is at the forefront of Taiwan’s newborn screening (NBS) efforts. In this Q&A, we speak with Dr Chien about how NBS works in Taiwan, drawing upon her experience as a clinician-researcher and lab director to explore key considerations around panel composition, sample collection, lab workflows, and hopes for the future of NBS.