Primary care is the cornerstone of effective health systems and care delivery. Southeast Asia is facing significant challenges due to demographic and lifestyle changes leading to rapidly rising prevalence of chronic disease. Adoption of digital solutions and electronic health records systems are laying down the infrastructure for transformation in primary care. Digitalisation of health records and clinical data provides opportunities for automation and analytics to streamline care delivery. Clinical decision support systems based on best practice clinical guidelines can raise the quality of care and deliver a more patient centric care experience.