{"id":142242,"date":"2023-01-16T02:19:53","date_gmt":"2023-01-16T02:19:53","guid":{"rendered":"https:\/\/labinsights.com\/acf_article\/penanda-biologis-dalam-trombosis-terkait-kanker-wawasan-dari-prof-anna-falanga-dan-cinzia-giaccherini\/"},"modified":"2026-01-14T12:04:56","modified_gmt":"2026-01-14T12:04:56","slug":"biomarkers-in-cancer-associated-thrombosis-insights-from-prof-anna-falanga-and-cinzia-giaccherini","status":"publish","type":"acf_article","link":"https:\/\/labinsights.com\/id\/disease-area\/oncology\/biomarkers-in-cancer-associated-thrombosis-insights-from-prof-anna-falanga-and-cinzia-giaccherini\/","title":{"rendered":"Penanda biologis dalam trombosis terkait kanker: wawasan dari Prof. Anna Falanga dan Cinzia Giaccherini"},"content":{"rendered":"

Dalam webinar<\/a> yang diselenggarakan pada Hari Trombosis Sedunia 2022, dua pakar koagulasi\u2014Prof. Anna Falanga, Profesor Hematologi di University of Milan Bicocca, dan Cinzia Giaccherini, seorang ahli biologi peneliti dengan pengalaman lebih dari 10 tahun dalam hemostasis dan trombosis\u2014membahas peran prediktif penanda biologis dalam trombosis terkait kanker (cancer-associated thrombosis, CAT).<\/p>\n

Prof. Anna Falanga memulai dengan menyajikan ikhtisar prediksi dan pencegahan risiko CAT. Studi kohort Inggris dan Denmark menunjukkan bahwa pasien dengan kanker memiliki risiko 4\u201311 kali lebih tinggi terkena tromboemboli vena (TEV) dibandingkan dengan pasien non-kanker, tergantung pada jenis kanker; dengan TEV memengaruhi morbiditas dan mortalitas pada pasien kanker.<\/p>\n

Untuk mencegah TEV, pasien kanker berisiko tinggi yang mungkin mendapat manfaat dari tromboprofilaksis primer perlu diidentifikasi. Modul penilaian risiko (Risk assessment modules, RAM) seperti skor Khorana dapat memprediksi risiko TEV pada pasien. RAM dapat ditambah dengan penanda biologis untuk meningkatkan prediksi. RAM dapat diperbesar dengan penanda biologis untuk meningkatkan prediksi.<\/p>\n

Cinzia Giaccherini kemudian membahas penanda biologis untuk prediksi CAT dan prognosis penyakit pada kanker paru-paru. Penanda biologis koagulasi seperti D-dimer tercatat berpotensi berguna dalam mengevaluasi risiko trombotik individu pasien. Terdapat bukti yang mendukung penggunaannya pada pasien kanker paru-paru, yang mana hal itu juga dapat menjadi indikasi prognosis yang buruk.<\/p>\n

Beberapa penelitian melaporkan adanya hubungan signifikan antara peningkatan kadar plasma D-dimer dengan beban tumor besar, perkembangan penyakit, dan mortalitas Penelitian lebih lanjut diperlukan untuk memperkuat bukti saat ini dan untuk mendorong penggunaan model berbasis penanda biologis koagulasi di masa mendatang dalam praktik klinis.<\/p>\n

Selama sesi Tanya Jawab, emboli paru tercatat sebagai yang paling umum di antara pasien kanker paru-paru, dengan diagnosis sering ditemukan saat skrining kanker. Terkait dengan pengobatan edoxaban pada TEV, direkomendasikan untuk melanjutkan pengobatan selama 12 bulan dengan dosis yang sama sebelum menyesuaikan jika TEV berlanjut.<\/p>\n

D-dimer dicatat sebagai penanda TEV yang menjanjikan dan prediktor prognosis penyakit. Disarankan bahwa populasi yang lebih menua dan pengobatan kanker yang lebih baru dapat dikaitkan dengan meningkatnya risiko trombosis pada semua jenis kanker.<\/p>\n

Prof. Anna Falanga, MD, adalah Profesor Hematologi di University of Milan Bicocca dan Chief, the Department of Immunohematology and Transfusion Medicine and the Thrombosis and Hemostasis Center, di Bergamo, Italia. Ia telah menulis lebih dari 300 publikasi dan menjadi editor tamu dari 21 volume, dan ia merupakan seorang ahli di bidang kanker dan trombosis.<\/em><\/p>\n

Cinzia Giaccherini adalah seorang ahli biologi peneliti dengan lebih dari 10 tahun pengalaman di Hemostasis and Thrombosis Laboratory of the Immunohematology and Transfusion Medicine division di Papa Giovanni XXIII Hospital di Bergamo (Italia). Ia juga sedang mengambil spesialisasi pascasarjana di bidang Statistik Medis dan Biometrik di University of Milan.<\/em><\/p>\n

Sumber lainnya:<\/strong><\/em> <\/p>\n

[1]<\/a> Falanga, A. et al. (2022) \u201cHow well do European patients understand cancer-associated thrombosis? A patient survey,\u201d Cancer Treatment and Research Communications, 31, p. 100557. Tersedia di: https:\/\/doi.org\/10.1016\/j.ctarc.2022.100557.<\/p>\n

[2] <\/a>Falanga, A. et al. (2021) \u201cManagement of cancer-associated thrombosis: Unmet needs and future perspectives,\u201d TH Open, 05(03). Tersedia di: https:\/\/doi.org\/10.1055\/s-0041-1736037. <\/p>\n

[3]<\/a> Falanga, A. et al. (2022) \u201cThrombotic complications in patients with cancer: Advances in pathogenesis, prevention, and treatment\u2014a report from ICTHIC 2021,\u201d Research and Practice in Thrombosis and Haemostasis, 6(5). Tersedia di: https:\/\/doi.org\/10.1002\/rth2.12744.<\/p>\n

[4]<\/a> Pesenti, M. et al. (2020) \u201cThrombin generation and D-dimer significantly predict for early disease progression and mortality in patients with gastrointestinal cancer,\u201d Blood, 136(Supplement 1), pp. 32\u201332. Tersedia di: https:\/\/doi.org\/10.1182\/blood-2020-136631.<\/p>\n

[5]<\/a> Falanga, A. et al. (2019) \u201cThrombotic risk assessment in a prospective cohort of newly diagnosed ambulatory cancer patients candidate to Chemotherapy,\u201d Blood, 134(Supplement_1), pp. 3642\u20133642. Tersedia di: https:\/\/doi.org\/10.1182\/blood-2019-129901.<\/p>\n","protected":false},"excerpt":{"rendered":"

Dalam webinar yang diselenggarakan pada Hari Trombosis Sedunia 2022, dua pakar koagulasi\u2014Prof. Anna Falanga, Profesor Hematologi di University of Milan Bicocca, dan Cinzia Giaccherini, seorang ahli biologi peneliti dengan pengalaman lebih dari 10 tahun dalam hemostasis dan trombosis\u2014membahas peran prediktif penanda biologis dalam trombosis terkait kanker (cancer-associated thrombosis, CAT). Prof. Anna Falanga memulai dengan menyajikan […]<\/p>\n","protected":false},"author":1,"featured_media":85651,"parent":0,"menu_order":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"no-sidebar","site-content-layout":"","ast-site-content-layout":"full-width-container","site-content-style":"unboxed","site-sidebar-style":"unboxed","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"tags":[12871,12880],"pillarandcategory":[287,292,282],"reporter":[13154,13253],"class_list":["post-142242","acf_article","type-acf_article","status-publish","has-post-thumbnail","hentry","tag-koagulasi","tag-onkologi","pillarandcategory-oncology","pillarandcategory-coagulation","pillarandcategory-disease-area","reporter-anna-falanga","reporter-cinzia-giaccherini"],"acf":[],"_links":{"self":[{"href":"https:\/\/labinsights.com\/id\/wp-json\/wp\/v2\/acf_article\/142242","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labinsights.com\/id\/wp-json\/wp\/v2\/acf_article"}],"about":[{"href":"https:\/\/labinsights.com\/id\/wp-json\/wp\/v2\/types\/acf_article"}],"author":[{"embeddable":true,"href":"https:\/\/labinsights.com\/id\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":3,"href":"https:\/\/labinsights.com\/id\/wp-json\/wp\/v2\/acf_article\/142242\/revisions"}],"predecessor-version":[{"id":143957,"href":"https:\/\/labinsights.com\/id\/wp-json\/wp\/v2\/acf_article\/142242\/revisions\/143957"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/labinsights.com\/id\/wp-json\/wp\/v2\/media\/85651"}],"wp:attachment":[{"href":"https:\/\/labinsights.com\/id\/wp-json\/wp\/v2\/media?parent=142242"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/labinsights.com\/id\/wp-json\/wp\/v2\/tags?post=142242"},{"taxonomy":"pillarandcategory","embeddable":true,"href":"https:\/\/labinsights.com\/id\/wp-json\/wp\/v2\/pillarandcategory?post=142242"},{"taxonomy":"reporter","embeddable":true,"href":"https:\/\/labinsights.com\/id\/wp-json\/wp\/v2\/reporter?post=142242"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}