{"id":142738,"date":"2021-08-06T06:05:16","date_gmt":"2021-08-06T06:05:16","guid":{"rendered":"https:\/\/labinsights.com\/acf_article\/csf%e3%83%90%e3%82%a4%e3%82%aa%e3%83%9e%e3%83%bc%e3%82%ab%e3%83%bc%e3%81%a8%e3%82%a2%e3%83%ab%e3%83%84%e3%83%8f%e3%82%a4%e3%83%9e%e3%83%bc%e7%97%85%e7%ae%a1%e7%90%86%e3%81%ab%e3%81%8a%e3%81%91\/"},"modified":"2026-01-08T12:26:44","modified_gmt":"2026-01-08T12:26:44","slug":"csf-biomarkers-and-their-role-in-alzheimers-disease-management","status":"publish","type":"acf_article","link":"https:\/\/labinsights.com\/ja\/operations\/immunoassay\/csf-biomarkers-and-their-role-in-alzheimers-disease-management\/","title":{"rendered":"CSF\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u7ba1\u7406\u306b\u304a\u3051\u308b\u305d\u306e\u5f79\u5272"},"content":{"rendered":"

\u4e16\u754c\u7684\u306a\u4eba\u53e3\u306e\u7d99\u7d9a\u7684\u306a\u9ad8\u9f62\u5316\u306e\u4e2d\u3067\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306f\u6df1\u523b\u3067\u6025\u901f\u306b\u5897\u52a0\u3059\u308b\u516c\u8846\u885b\u751f\u4e0a\u306e\u61f8\u5ff5\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u73fe\u5728\u3001\u30a2\u30b8\u30a2\u592a\u5e73\u6d0b\u5730\u57df\u3060\u3051\u3067\u7d042,300\u4e07\u4eba\u304c\u7f79\u60a3\u3057\u3066\u3044\u308b\u3068\u63a8\u5b9a\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u306e\u6570\u306f2050\u5e74\u306b\u306f7,000\u4e07\u4eba\u3092\u8d85\u3048\u308b\u3068\u898b\u8fbc\u307e\u308c\u3066\u3044\u307e\u3059[1]\u3002FDA\u304c\u6700\u8fd1\u627f\u8a8d\u3057\u305f\u65b0\u305f\u306a\u00a0\u6cbb\u7642\u4ecb\u5165\u00a0\u306b\u591a\u304f\u306e\u6ce8\u76ee\u304c\u96c6\u307e\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u3053\u306e\u75be\u60a3\u304c\u62e1\u5927\u3059\u308b\u72b6\u6cc1\u306b\u5bfe\u5fdc\u3059\u308b\u306b\u306f\u3001\u81e8\u5e8a\u691c\u67fb\u8a3a\u65ad\u3082\u4e0d\u53ef\u6b20\u3067\u3059\u3002<\/p>\n

CSF\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u306f\uff1f<\/h3>\n

\u8907\u6570\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u8a3a\u65ad\u30d7\u30ed\u30bb\u30b9\u306b\u304a\u3051\u308b3\u3064\u306e\u4e3b\u8981\u8133\u810a\u9ac4\u6db2\uff08CSF\uff09\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b \u03b2-\u30a2\u30df\u30ed\u30a4\u30c942\uff08\u03b1\u03b242\uff09\u3001\u7dcf\u30bf\u30a6\uff08T-tau\uff09\u3001\u304a\u3088\u3073\u30ea\u30f3\u9178\u5316\u30bf\u30a6\uff08P-tau\uff09\u306e\u4fa1\u5024\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u03b1\u03b242\u30ec\u30d9\u30eb\u306fCSF\u5185\u3067\u3088\u308a\u4f4e\u3044\u6fc3\u5ea6\u3067\u691c\u51fa\u3055\u308c\u3001\u3053\u306e\u5909\u5316\u306f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u304c\u6b63\u5f0f\u306b\u8a3a\u65ad\u3055\u308c\u308b\u307e\u3067\u306b\u5c11\u306a\u304f\u3068\u30825\u5e74\u524d\u304b\u3089\u73fe\u308c\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059[2]\u3002\u30cb\u30e5\u30fc\u30ed\u30f3\u5909\u6027\u306e\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308bT-tau\u3068P-tau\u3082\u3001\u3044\u305a\u308c\u3082\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u3092\u8d85\u3048\u308b\u5897\u52a0\u3068\u3057\u3066\u4e00\u8cab\u3057\u3066\u89b3\u5bdf\u3055\u308c\u3066\u3044\u307e\u3059[3]\u3002<\/p>\n

CSF\u306f\u8170\u690e\u7a7f\u523a\u3067\u63a1\u53d6\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u3001\u305d\u306e\u5185\u5bb9\u7269\u306f\u8133\u306e\u74b0\u5883\u3092\u76f4\u63a5\u53cd\u6620\u3059\u308b\u3082\u306e\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u308c\u3067\u3082\u3001CSF\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306f\u307e\u3060\u81e8\u5e8a\u8a3a\u65ad\u3067\u5e83\u304f\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u4eca\u65e5\u307e\u3067\u3001\u78ba\u7acb\u3055\u308c\u305f\u30ab\u30c3\u30c8\u30aa\u30d5\u30ec\u30d9\u30eb\u306b\u5bfe\u3059\u308b\u6b63\u5f0f\u306a\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u3053\u308c\u3089\u306e\u5024\u3092\u6a19\u6e96\u5316\u3059\u308b\u305f\u3081\u306e\u7814\u7a76\u304c\u9032\u884c\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

National Institute on Aging and Alzheimer\u2019s Association\u00a0(NIA-AA)\u00a0\u304c\u660e\u78ba\u306b\u793a\u3057\u305f\u8a3a\u65ad\u8a55\u4fa1[4]\u3084\u3001Alzheimer\u2019s Association\u306e\u5916\u90e8\u54c1\u8cea\u7ba1\u7406\u30d7\u30ed\u30b0\u30e9\u30e0\u00a0[5]\u306a\u3069\u306e\u6700\u65b0\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306b\u3088\u308a\u3001\u75be\u60a3\u30b9\u30c6\u30fc\u30b8\u306b\u304b\u304b\u308f\u3089\u305aCSF\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3092\u81e8\u5e8a\u7684\u306b\u4f7f\u7528\u3059\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u307e\u3063\u3066\u3044\u307e\u3059\u3002\u627f\u8a8d\u3055\u308c\u305f\u5834\u5408\u3001\u81ea\u52d5\u5316\u306b\u3088\u3063\u3066CSF\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc{sp}\u306e\u4f7f\u7528\u3092\u5897\u3084\u3059\u3053\u3068\u3082\u53ef\u80fd\u3067\u3001\u624b\u4f5c\u696d\u306b\u3088\u308b\u3070\u3089\u3064\u304d\u3092\u6e1b\u3089\u3059\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n

\u30bf\u30a4\u30e0\u30ea\u30fc\u306a\u8a3a\u65ad\u306e\u30e1\u30ea\u30c3\u30c8<\/h3>\n

\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306f\u3001\u307b\u3068\u3093\u3069\u306e\u5834\u5408\u3001\u300c\u3068\u304d\u3069\u304d\u7269\u5fd8\u308c\u3092\u3059\u308b\u300d\u3068\u3044\u3063\u305f\u3001\u52a0\u9f62\u306e\u305b\u3044\u306b\u3057\u3084\u3059\u3044\u5c0f\u3055\u306a\u75c7\u72b6\u304b\u3089\u59cb\u307e\u308a\u307e\u3059\u3002\u3053\u306e\u6642\u70b9\u3067\u60a3\u8005\u306f\u3001\u4e3b\u89b3\u7684\u306a\u8a8d\u77e5\u6a5f\u80fd\u4f4e\u4e0b\u3092\u7d4c\u9a13\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u304f\u3001\u8a8d\u77e5\u6a5f\u80fd\u304c\u640d\u306a\u308f\u308c\u3066\u3044\u308b\u304a\u305d\u308c\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u901a\u5e38\u306e\u81e8\u5e8a\u8a3a\u5bdf\u3060\u3051\u3067\u306f\u305d\u306e\u969c\u5bb3\u3092\u78ba\u8a8d\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n

\u3053\u306e\u4e00\u9023\u306e\u6d41\u308c\u306e\u6b21\u306e\u6bb5\u968e\u306f\u8efd\u5ea6\u8a8d\u77e5\u969c\u5bb3\uff08MCI\uff09\u3067\u3042\u308a\u3001\u3053\u3053\u3067\u306f\u795e\u7d4c\u753b\u50cf\u691c\u67fb\u306b\u3088\u3063\u3066\u81e8\u5e8a\u7684\u306a\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u5f97\u3089\u308c\u307e\u3059\u3002MCI\u306f\u4ed6\u306e\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3067\u3082\u307f\u3089\u308c\u308b\u305f\u3081\u3001CSF\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306f\u9451\u5225\u8a3a\u65ad\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002\u751f\u7406\u5b66\u7684\u5909\u5316\u3068\u81e8\u5e8a\u75c7\u72b6\u3068\u306e\u9593\u306b\u6642\u9593\u5dee\u304c\u3042\u308b\u3053\u3068\u3001\u307e\u305f MCI \u304c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u30ea\u30b9\u30af\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u3092\u8e0f\u307e\u3048\u308b\u3068\u3001\u30bf\u30a4\u30e0\u30ea\u30fc\u306a\u8a3a\u65ad\u306e\u305f\u3081\u306b CSF \u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u60a3\u8005\u3055\u3093\u306e\u8a3a\u7642\u4f53\u9a13\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

CSF \u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u304c\u5229\u7528\u53ef\u80fd\u306b\u306a\u308b\u524d\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u8a3a\u65ad\u306f\u3001\u8133\u5185\u306e\u30a2\u30df\u30ed\u30a4\u30c9\u30d7\u30e9\u30fc\u30af\u3068\u3044\u3046\u7279\u5fb4\u7684\u6240\u898b\u3092\u6349\u3048\u308b\u30a2\u30df\u30ed\u30a4\u30c9 PET \u30b9\u30ad\u30e3\u30f3\u306a\u3069\u306e\u795e\u7d4c\u753b\u50cf\u691c\u67fb\u306b\u4f9d\u5b58\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3053\u306e\u65b9\u6cd5\u306b\u306f\u3001\u8a3a\u65ad\u304c\u9045\u304f\u306a\u308a\u3084\u3059\u3044\u3053\u3068\u3084\u3001\u88c5\u7f6e\u3084\u5c02\u9580\u30b9\u30bf\u30c3\u30d5\u3078\u306e\u30a2\u30af\u30bb\u30b9\u304c\u9650\u3089\u308c\u3066\u3044\u308b\u3053\u3068\u306a\u3069\u3001\u3055\u307e\u3056\u307e\u306a\u5236\u7d04\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u3046\u3057\u305f\u8981\u56e0\u306b\u3088\u308a\u3001\u60a3\u8005\u306e 50\u301c70\uff05 \u304c\u6b63\u5f0f\u306a\u8a3a\u65ad\u3092\u53d7\u3051\u3066\u3044\u306a\u3044{sp} \u3053\u3068\u304c\u8aac\u660e\u3067\u304d\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n

\u65e9\u671f\u306b\u8a3a\u65ad\u304c\u3064\u3051\u3070\u3001\u6587\u732e\uff3b6\uff3d\u306b\u793a\u3055\u308c\u3066\u3044\u308b\u3088\u3046\u306a\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u78ba\u5b9a\u8a3a\u65ad\u304c\u53ef\u80fd\u306b\u306a\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u4ecb\u5165\u7642\u6cd5\u306e\u5b9f\u65bd\u3084\u81e8\u5e8a\u8a66\u9a13\uff3b7\uff3d\u3078\u306e\u767b\u9332\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002 \u8a3a\u5bdf\u5ba4\u306e\u5916\u3067\u306f\u3001\u5341\u5206\u306a\u60c5\u5831\u3092\u5f97\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u60a3\u8005\u81ea\u8eab\u304c\u4eca\u5f8c\u306e\u751f\u6d3b\u3084\u7642\u990a\u306e\u9078\u629e\u80a2\u3001\u3055\u3089\u306b\u306f\u6cd5\u7684\u306a\u624b\u7d9a\u304d\u306b\u95a2\u3059\u308b\u6c7a\u5b9a\u3092\u884c\u3048\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002\u65e9\u671f\u8a3a\u65ad\u306f\u3001\u4eca\u5f8c\u6570\u5341\u5e74\u306b\u308f\u305f\u308a\u3001\u305d\u306e\u56fd\u306e\u533b\u7642\u63d0\u4f9b\u4f53\u5236\u3084\u653f\u7b56\u3092\u3069\u306e\u3088\u3046\u306b\u69cb\u7bc9\u3057\u3066\u3044\u304f\u304b{sp} \u3092\u691c\u8a0e\u3059\u308b\u3046\u3048\u3067\u306e\u91cd\u8981\u306a\u60c5\u5831\u306b\u3082\u306a\u308a\u307e\u3059\u3002<\/p>\n

\u30b3\u30f3\u30d1\u30cb\u30aa\u30f3\u8a3a\u65ad\u3068\u3057\u3066\u306e\u6d3b\u7528\u53ef\u80fd\u6027<\/h3>\n

SF \u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u81e8\u5e8a\u7d4c\u904e\u306b\u4ecb\u5165\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u305f\u75be\u60a3\u4fee\u98fe\u7642\u6cd5\uff08DMT\uff09\u306e\u81e8\u5e8a\u8a66\u9a13\uff3b8\uff3d\u3067\u3059\u3067\u306b\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u8a72\u5f53\u60a3\u8005\u3092\u9069\u5207\u306b\u5c64\u5225\u5316\u3057\u3066\u81e8\u5e8a\u8a66\u9a13\u306b\u767b\u9332\u3059\u308b\u305f\u3081\u306b\u3001CSF \u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\uff08\u304a\u3088\u3073 PET \u30b9\u30ad\u30e3\u30f3\uff09\u306f\u3001\u751f\u7406\u5b66\u7684\u5909\u5316\u306e\u5b58\u5728\u3092\u78ba\u8a8d\u3059\u308b\u78ba\u8a3c\u691c\u67fb\u3068\u3057\u3066\u5b9f\u65bd\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u6e2c\u5b9a\u6cd5\u306e\u7a2e\u985e\u304c\u5897\u3048\u3001\u6a19\u6e96\u5316\u304c\u9032\u3080\u3053\u3068\u3067\u3001CSF \u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306f\u81e8\u5e8a\u8a66\u9a13\u306b\u304a\u3051\u308b\u91cd\u8981\u306a\u30de\u30a4\u30eb\u30b9\u30c8\u30fc\u30f3\u3092\u5e45\u5e83\u304f\u652f\u63f4\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u4e00\u65b9\u3067\u3001\u8907\u6570\u56de\u306e\u8170\u690e\u7a7f\u523a\u306f\u60a3\u8005\u3055\u3093\u306b\u3068\u3063\u3066\u8ca0\u62c5\u304c\u5927\u304d\u3044\u5834\u5408\u304c\u3042\u308a\u3001\u4ee3\u66ff\u3068\u306a\u308b\u8840\u6db2\u30d9\u30fc\u30b9\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3092\u958b\u767a\u3059\u308b\u305f\u3081\u306e\u3055\u3089\u306a\u308b\u7814\u7a76\u306e\u5fc5\u8981\u6027\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u591a\u304f\u306e\u7814\u7a76\u304b\u3089\u3001\u65e9\u671f\u306b\u8a3a\u65ad\u3092\u78ba\u5b9a\u3059\u308b\u3053\u3068\u306b\u306f\u3001\u3088\u308a\u65e9\u671f\u304b\u3089\u306e\u6cbb\u7642\u958b\u59cb\u3084 DMT \u3078\u306e\u65e9\u671f\u5c0e\u5165\u306a\u3069\u3001\u3055\u307e\u3056\u307e\u306a\u5229\u70b9\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u65b0\u305f\u306a\u85ac\u5264\u304c\u4e0a\u5e02\u3055\u308c\u305f\u3053\u3068\u3067\u3001\u3053\u3046\u3057\u305f\u7406\u8ad6\u4e0a\u306e\u5229\u70b9\u304c\u5b9f\u969b\u306e\u3082\u306e\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u307e\u3063\u3066\u3044\u307e\u3059\u65b0\u85ac\u306e\u767b\u5834\u306f\u3001\u3088\u308a\u591a\u304f\u306e\u533b\u7642\u5f93\u4e8b\u8005\u304c\u65e5\u5e38\u8a3a\u7642\u3067 CSF \u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u4f7f\u7528\u3092\u53d7\u3051\u5165\u308c\u308b\u304d\u3063\u304b\u3051\u306b\u3082\u306a\u308a\u5f97\u307e\u3059\u3002<\/p>\n

\u53c2\u8003\u6587\u732e\uff1a<\/em><\/p>\n

[1]<\/a> \u30a2\u30b8\u30a2\u592a\u5e73\u6d0b\u5730\u57df\u306b\u304a\u3051\u308b\u8a8d\u77e5\u75c72014\u5e74\u5831\u544a\u66f8\u3001Alzheimer\u2019s Disease International<\/p>\n

[2]<\/a>\u00a0Buchhave, P.et al. (2012)\u00a0Cerebrospinal Fluid Levels of \u03b2-Amyloid 1-42, but Not of Tau, Are Fully Changed Already 5 to 10 Years Before the Onset of Alzheimer Dementia.\u00a0Archives of General Psychiatry<\/i>, 69(1), pp98.<\/p>\n

[3]<\/a>\u00a0Olsson, B., et al. (2016) CSF and blood biomarkers for the diagnosis of Alzheimer’s disease: a systematic review and meta-analysis.The Lancet Neurology<\/em>, 15, pp673-684.<\/p>\n

[4]<\/a>\u00a0\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u8a3a\u65ad\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\uff0c\u56fd\u7acb\u533b\u85ac\u54c1\u98df\u54c1\u885b\u751f\u7814\u7a76\u6240<\/p>\n

[5]<\/a>\u00a0The Alzheimer’s Association QC program for CSF and blood biomarkers<\/p>\n

[6]<\/a> Dubois, B.et al. (2016) Timely diagnosis for Alzheimer’s Disease: A Literature Review on Benefits and Challenges.Journal of Alzheimer’s Disease<\/em>, 49, pp617-631.<\/p>\n

[7]<\/a>\u00a0Lleo, A.et al. (2014) Cerebrospinal fluid biomarkers in trials for Alzheimer and Parkinson diseases.Nature Reviews Neurology<\/em>, 11, pp41-55.<\/p>\n

[8]<\/a>\u00a0Horgan, D.et al. (2020) Biomarker Testing: Piercing the Fog of Alzheimer’s and Related Dementia.\u751f\u7269\u533b\u5b66\u30cf\u30d6<\/p>\n","protected":false},"excerpt":{"rendered":"

\u4e16\u754c\u7684\u306a\u4eba\u53e3\u306e\u7d99\u7d9a\u7684\u306a\u9ad8\u9f62\u5316\u306e\u4e2d\u3067\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306f\u6df1\u523b\u3067\u6025\u901f\u306b\u5897\u52a0\u3059\u308b\u516c\u8846\u885b\u751f\u4e0a\u306e\u61f8\u5ff5\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u73fe\u5728\u3001\u30a2\u30b8\u30a2\u592a\u5e73\u6d0b\u5730\u57df\u3060\u3051\u3067\u7d042,300\u4e07\u4eba\u304c\u7f79\u60a3\u3057\u3066\u3044\u308b\u3068\u63a8\u5b9a\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u306e\u6570\u306f2050\u5e74\u306b\u306f7,000\u4e07\u4eba\u3092\u8d85\u3048\u308b\u3068\u898b\u8fbc\u307e\u308c\u3066\u3044\u307e\u3059[1]\u3002FDA\u304c\u6700\u8fd1\u627f\u8a8d\u3057\u305f\u65b0\u305f\u306a\u00a0\u6cbb\u7642\u4ecb\u5165\u00a0\u306b\u591a\u304f\u306e\u6ce8\u76ee\u304c\u96c6\u307e\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u3053\u306e\u75be\u60a3\u304c\u62e1\u5927\u3059\u308b\u72b6\u6cc1\u306b\u5bfe\u5fdc\u3059\u308b\u306b\u306f\u3001\u81e8\u5e8a\u691c\u67fb\u8a3a\u65ad\u3082\u4e0d\u53ef\u6b20\u3067\u3059\u3002 CSF\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u306f\uff1f \u8907\u6570\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u8a3a\u65ad\u30d7\u30ed\u30bb\u30b9\u306b\u304a\u3051\u308b3\u3064\u306e\u4e3b\u8981\u8133\u810a\u9ac4\u6db2\uff08CSF\uff09\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b \u03b2-\u30a2\u30df\u30ed\u30a4\u30c942\uff08\u03b1\u03b242\uff09\u3001\u7dcf\u30bf\u30a6\uff08T-tau\uff09\u3001\u304a\u3088\u3073\u30ea\u30f3\u9178\u5316\u30bf\u30a6\uff08P-tau\uff09\u306e\u4fa1\u5024\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u03b1\u03b242\u30ec\u30d9\u30eb\u306fCSF\u5185\u3067\u3088\u308a\u4f4e\u3044\u6fc3\u5ea6\u3067\u691c\u51fa\u3055\u308c\u3001\u3053\u306e\u5909\u5316\u306f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u304c\u6b63\u5f0f\u306b\u8a3a\u65ad\u3055\u308c\u308b\u307e\u3067\u306b\u5c11\u306a\u304f\u3068\u30825\u5e74\u524d\u304b\u3089\u73fe\u308c\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059[2]\u3002\u30cb\u30e5\u30fc\u30ed\u30f3\u5909\u6027\u306e\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308bT-tau\u3068P-tau\u3082\u3001\u3044\u305a\u308c\u3082\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u3092\u8d85\u3048\u308b\u5897\u52a0\u3068\u3057\u3066\u4e00\u8cab\u3057\u3066\u89b3\u5bdf\u3055\u308c\u3066\u3044\u307e\u3059[3]\u3002 CSF\u306f\u8170\u690e\u7a7f\u523a\u3067\u63a1\u53d6\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u3001\u305d\u306e\u5185\u5bb9\u7269\u306f\u8133\u306e\u74b0\u5883\u3092\u76f4\u63a5\u53cd\u6620\u3059\u308b\u3082\u306e\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u308c\u3067\u3082\u3001CSF\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306f\u307e\u3060\u81e8\u5e8a\u8a3a\u65ad\u3067\u5e83\u304f\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u4eca\u65e5\u307e\u3067\u3001\u78ba\u7acb\u3055\u308c\u305f\u30ab\u30c3\u30c8\u30aa\u30d5\u30ec\u30d9\u30eb\u306b\u5bfe\u3059\u308b\u6b63\u5f0f\u306a\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u3053\u308c\u3089\u306e\u5024\u3092\u6a19\u6e96\u5316\u3059\u308b\u305f\u3081\u306e\u7814\u7a76\u304c\u9032\u884c\u3057\u3066\u3044\u307e\u3059\u3002 National Institute on Aging and Alzheimer\u2019s Association\u00a0(NIA-AA)\u00a0\u304c\u660e\u78ba\u306b\u793a\u3057\u305f\u8a3a\u65ad\u8a55\u4fa1[4]\u3084\u3001Alzheimer\u2019s Association\u306e\u5916\u90e8\u54c1\u8cea\u7ba1\u7406\u30d7\u30ed\u30b0\u30e9\u30e0\u00a0[5]\u306a\u3069\u306e\u6700\u65b0\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306b\u3088\u308a\u3001\u75be\u60a3\u30b9\u30c6\u30fc\u30b8\u306b\u304b\u304b\u308f\u3089\u305aCSF\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3092\u81e8\u5e8a\u7684\u306b\u4f7f\u7528\u3059\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u307e\u3063\u3066\u3044\u307e\u3059\u3002\u627f\u8a8d\u3055\u308c\u305f\u5834\u5408\u3001\u81ea\u52d5\u5316\u306b\u3088\u3063\u3066CSF\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc{sp}\u306e\u4f7f\u7528\u3092\u5897\u3084\u3059\u3053\u3068\u3082\u53ef\u80fd\u3067\u3001\u624b\u4f5c\u696d\u306b\u3088\u308b\u3070\u3089\u3064\u304d\u3092\u6e1b\u3089\u3059\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002 \u30bf\u30a4\u30e0\u30ea\u30fc\u306a\u8a3a\u65ad\u306e\u30e1\u30ea\u30c3\u30c8 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