{"id":142779,"date":"2024-02-21T09:10:17","date_gmt":"2024-02-21T09:10:17","guid":{"rendered":"https:\/\/labinsights.com\/acf_article\/%e6%95%97%e8%a1%80%e7%97%87%e3%81%ae%e7%ae%a1%e7%90%86%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%83%90%e3%82%a4%e3%82%aa%e3%83%9e%e3%83%bc%e3%82%ab%e3%83%bc%e3%81%ae%e5%bd%b9%e5%89%b2\/"},"modified":"2026-02-17T05:30:58","modified_gmt":"2026-02-17T05:30:58","slug":"the-role-of-biomarkers-in-management-of-sepsis","status":"publish","type":"acf_article","link":"https:\/\/labinsights.com\/ja\/disease-area\/sepsis\/the-role-of-biomarkers-in-management-of-sepsis\/","title":{"rendered":"\u6557\u8840\u75c7\u306e\u7ba1\u7406\u306b\u304a\u3051\u308b\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u5f79\u5272"},"content":{"rendered":"

\u7b2c\u4e09\u56de\u6557\u8840\u75c7\u304a\u3088\u3073\u6557\u8840\u75c7\u6027\u30b7\u30e7\u30c3\u30af\u306e\u56fd\u969b\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9\u5b9a\u7fa9\uff08Sepsis-3\uff09<\/a>\u306f\u3001\u6557\u8840\u75c7\u3092\u300c\u611f\u67d3\u306b\u5bfe\u3059\u308b\u8abf\u7bc0\u4e0d\u5168\u306e\u5bbf\u4e3b\u5fdc\u7b54\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u751f\u547d\u3092\u8105\u304b\u3059\u81d3\u5668\u6a5f\u80fd\u4e0d\u5168\u300d\u3068\u5b9a\u7fa9\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u6557\u8840\u75c7\u6027\u30b7\u30e7\u30c3\u30af\u306f\u3001\u300c\u57fa\u790e\u306b\u3042\u308b\u5faa\u74b0\u7570\u5e38\u3001\u7d30\u80de\u7570\u5e38\u304a\u3088\u3073\u4ee3\u8b1d\u7570\u5e38\u304c\u3001\u6557\u8840\u75c7\u5358\u72ec\u3088\u308a\u3082\u6b7b\u4ea1\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u6557\u8840\u75c7\u306e\u30b5\u30d6\u30bb\u30c3\u30c8\u300d\u3068\u3057\u3066\u5b9a\u7fa9\u3055\u308c\u307e\u3059\u3002 \u6557\u8840\u75c7\u306f\u3001\u5358\u4e00\u306e\u8a3a\u65ad\u691c\u67fb\u304c\u306a\u3044\u305f\u3081\u81e8\u5e8a\u8a3a\u65ad\u3068\u306a\u308a\u307e\u3059\u3002\u751f\u7406\u5b66\u7684\u7570\u5e38\u304a\u3088\u3073\u691c\u67fb\u7570\u5e38\u306e\u4e21\u65b9\u304c\u5b58\u5728\u3057\u5f97\u307e\u3059\u3002Sepsis-3\u306f\u3001\u300c\u91cd\u75c7\u6557\u8840\u75c7\u300d\u3068\u3044\u3046\u7528\u8a9e\u3092\u6392\u9664\u3057\u3001\u4ee3\u308f\u308a\u306b\u300c\u6557\u8840\u75c7\u6027\u30b7\u30e7\u30c3\u30af\u300d\u304a\u3088\u3073\u300c\u6557\u8840\u75c7\u300d\u3092\u5b9a\u7fa9\u30fb\u5c64\u5225\u5316\u3057\u3001\u6557\u8840\u75c7\u60a3\u8005\u306e\u3088\u308a\u65e9\u671f\u306e\u8a8d\u8b58\u304a\u3088\u3073\u3088\u308a\u30bf\u30a4\u30e0\u30ea\u30fc\u306a\u7ba1\u7406\u3092\u5bb9\u6613\u306b\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u307e\u3057\u305f\u3002\u6557\u8840\u75c7\u306f\u91cd\u75c7\u5ea6\u306e\u30b9\u30da\u30af\u30c8\u30eb\u3068\u3057\u3066\u73fe\u308c\u307e\u3059\u3002\u8a3a\u65ad\u306f\u4e0d\u78ba\u304b\u306a\u53ef\u80fd\u6027\u3082\u3042\u308b\u304c\u3001\u6557\u8840\u75c7\u3092\u6709\u3059\u308b\u3059\u3079\u3066\u306e\u60a3\u8005\u306b\u304a\u3044\u3066\u6025\u901f\u304b\u3064\u91cd\u7be4\u306a\u60aa\u5316\u306e\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u6557\u8840\u75c7\u306e\u53ef\u80fd\u6027\u304c\u3042\u308b\u5834\u5408\u306f\u5e38\u306b\u4ecb\u5165\u304c\u5fc5\u8981\u3067\u3059[1]\u3002<\/p>\n

\u300cGlobal Burden of Disease\u300d\u306e\u7814\u7a76<\/a>\u3067\u306f\u3001195\u306e\u56fd\u3068\u5730\u57df\u306b\u304a\u3051\u308b1\u5104900\u4e07\u4ef6\u306e\u6b7b\u4ea1\u8a18\u9332\u3068860\u4e07\u4ef6\u306e\u75c5\u9662\u8a18\u9332\u306e\u30c7\u30fc\u30bf\u3092\u7528\u3044\u3066\u3001\u4e16\u754c\u4e2d\u306e\u6557\u8840\u75c7\u306e\u8ca0\u62c5\u3092\u63a8\u5b9a\u3057\u307e\u3057\u305f\u30022017\u5e74\u306b\u306f\u6557\u8840\u75c7\u306e\u75c7\u4f8b\u304c4,900\u4e07\u4ef6\u3001\u6b7b\u4ea1\u4f8b\u304c1,100\u4e07\u4ef6\u3068\u3001\u3053\u308c\u307e\u3067\u306e\u63a8\u5b9a\u306e2\u500d\u3067\u3042\u308a\u3001\u4e16\u754c\u4e2d\u3067\u6557\u8840\u75c7\u306b\u95a2\u9023\u3059\u308b\u6b7b\u4ea1\u4f8b\u306f5\u4f8b\u4e2d1\u4f8b\u306b\u4e0a\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u307e\u3057\u305f\u3002\u591a\u304f\u306e\u4eba\u304c\u9632\u3050\u3053\u3068\u304c\u3067\u304d\u308b\u72b6\u614b\u3067\u4ea1\u304f\u306a\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u554f\u984c\u3067\u3057\u305f\u3002\u30aa\u30fc\u30b9\u30c8\u30e9\u30ea\u30a2\u306b\u304a\u3051\u308b\u6557\u8840\u75c7\u306e\u8ca0\u62c5\u306b\u95a2\u3059\u308b\u4ee5\u524d\u306e\u63a8\u5b9a\u5024\u306f\u3001\u4e3b\u306b\u96c6\u4e2d\u6cbb\u7642\u5ba4\u3067\u6cbb\u7642\u3055\u308c\u305f\u75c7\u4f8b\u3092\u57fa\u306b\u3057\u3066\u304a\u308a\u3001\u75c7\u4f8b\u6570\u306f18,000\u4eba\u3001\u6b7b\u4ea1\u8005\u6570\u306f5,000\u4eba\u3067\u3057\u305f\u3002 \u3057\u304b\u3057\u3001\u5148\u8ff0\u306e\u300cGlobal Burden of Disease\u300d\u306e\u7814\u7a76\u306b\u3088\u308b\u63a8\u5b9a\u3067\u306f\u3001\u75c5\u9662\u5916\u3067\u767a\u751f\u3059\u308b\u6557\u8840\u75c7\u3092\u542b\u3081\u3001\u30aa\u30fc\u30b9\u30c8\u30e9\u30ea\u30a2\u3067\u306e\u75c7\u4f8b\u6570\u306f55,000\u4f8b\u3001\u6b7b\u4ea1\u8005\u6570\u306f8,700\u4f8b\u3068\u306a\u308a\u3001\u554f\u984c\u306e\u898f\u6a21\u306b\u3064\u3044\u3066\u3088\u308a\u6b63\u78ba\u306a\u5168\u4f53\u50cf\u304c\u5f97\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u6557\u8840\u75c7\u306f\u3001\u611f\u67d3\u306b\u5bfe\u3059\u308b\u8eab\u4f53\u306e\u5fdc\u7b54\u304c\u81ea\u8eab\u306e\u7d44\u7e54\u304a\u3088\u3073\u5668\u5b98\u3092\u640d\u50b7\u3059\u308b\u3068\u304d\u306b\u767a\u751f\u3059\u308b\u3001\u6642\u9593\u7684\u306b\u91cd\u8981\u306a\u533b\u5b66\u7684\u7dca\u6025\u4e8b\u614b\u3067\u3059\u3002\u65e9\u671f\u306b\u767a\u898b\u3055\u308c\u305a\u8fc5\u901f\u306a\u6cbb\u7642\u304c\u884c\u308f\u308c\u306a\u3051\u308c\u3070\u3001\u30b7\u30e7\u30c3\u30af\u3084\u591a\u81d3\u5668\u4e0d\u5168\u304c\u751f\u3058\u3001\u6b7b\u306b\u81f3\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002\u6557\u8840\u75c7\u306f\u3042\u3089\u3086\u308b\u5e74\u9f62\u5c64\u3001\u5e45\u5e83\u3044\u81e8\u5e8a\u5206\u91ce\u306e\u60a3\u8005\u306b\u767a\u751f\u3057\u307e\u3059\u304c\u3001\u7279\u306b\u975e\u5e38\u306b\u82e5\u3044\u4eba\u3001\u975e\u5e38\u306b\u9ad8\u9f62\u306e\u4eba\u3001\u30a2\u30dc\u30ea\u30b8\u30cb\u3084\u30c8\u30ec\u30b9\u6d77\u5ce1\u8af8\u5cf6\u6c11\u306e\u767a\u751f\u304c\u76ee\u7acb\u3061\u307e\u3059\u3002\u3057\u304b\u3057\u30012016\u5e74\u306e\u8abf\u67fb\u306b\u3088\u308b\u3068\u3001\u30aa\u30fc\u30b9\u30c8\u30e9\u30ea\u30a2\u4eba\u306e60%\u304c\u6557\u8840\u75c7\u3092\u805e\u3044\u305f\u3053\u3068\u304c\u306a\u304f\u300114%\u3057\u304b\u75c7\u72b6\u306e1\u3064\u3092\u6319\u3052\u308b\u3053\u3068\u304c\u3067\u304d\u306a\u304b\u3063\u305f\u305f\u3081\u3001\u75c5\u6c17\u306b\u5bfe\u3059\u308b\u610f\u8b58\u306f\u4f4e\u3044\u72b6\u6cc1\u3067\u3059\u3002\u307e\u305f\u3001\u6557\u8840\u75c7\u306b\u3088\u308b\u91cd\u5927\u306a\u6b7b\u4ea1\u3068\u969c\u5bb3\u306b\u5bfe\u51e6\u3059\u308b\u305f\u3081\u306b\u3001\u5165\u9662\u524d\u3068\u5165\u9662\u4e2d\u306e\u8a8d\u8b58\u304a\u3088\u3073\u6cbb\u7642\u306b\u53d6\u308a\u7d44\u3080\u5354\u8abf\u7684\u306a\u56fd\u5bb6\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u5fc5\u8981\u3067\u3059[2]\u3002<\/p>\n

\u6557\u8840\u75c7\u306e\u7ba1\u7406\u306b\u304a\u3051\u308b\u30d7\u30ed\u30ab\u30eb\u30b7\u30c8\u30cb\u30f3\u306e\u5f79\u5272<\/h2>\n

\u91cd\u75c7\u611f\u67d3\u75c7\u304a\u3088\u3073\u6557\u8840\u75c7\u3092\u6709\u3059\u308b\u91cd\u75c7\u60a3\u8005\u306e\u81e8\u5e8a\u7ba1\u7406\u306f\u3001\u8a3a\u65ad\u304a\u3088\u3073\u51e6\u7f6e\u306e\u6c7a\u5b9a\u307e\u3067\u306e\u6642\u9593\u3092\u77ed\u7e2e\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u6539\u5584\u3067\u304d\u307e\u3059\uff08\u3059\u306a\u308f\u3061\u3001\u7d30\u83cc\u611f\u67d3\u5bfe\u771f\u83cc\u611f\u67d3\u5bfe\u975e\u611f\u67d3\u75c5\u56e0\u306e\u533a\u5225\uff09\u3002\u3055\u3089\u306b\u3001\u65e9\u671f\u30ea\u30b9\u30af\u5c64\u5225\u5316\u304a\u3088\u3073\u4e88\u5f8c\u60c5\u5831\u306e\u63d0\u4f9b\u306b\u3088\u308a\u3001\u533b\u7642\u73fe\u5834\u306e\u610f\u601d\u6c7a\u5b9a\u3092\u6539\u5584\u3067\u304d\u307e\u3059\uff08\u4f8b\uff1a\u65e9\u671f\u9000\u9662\u307e\u305f\u306f\u30b1\u30a2\u306e\u6f38\u5897\uff09\u3002\u7e70\u308a\u8fd4\u3057\u6e2c\u5b9a\u3059\u308b\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306f\u307e\u305f\u3001\u60a3\u8005\u306e\u500b\u3005\u306e\u30cb\u30fc\u30ba\u306b\u5408\u308f\u305b\u3066\u6cbb\u7642\u3092\u8abf\u6574\u3059\u308b\u305f\u3081\u306e\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u306b\u3082\u5f79\u7acb\u3061\u307e\u3059\uff08\u6297\u751f\u7269\u8cea\u306e\u7ba1\u7406\uff09\u3002\u3053\u308c\u306b\u95a2\u9023\u3057\u3066\u3001\u5bbf\u4e3b\u5fdc\u7b54\u304a\u3088\u3073\u8840\u6db2\u611f\u67d3\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b\u30d7\u30ed\u30ab\u30eb\u30b7\u30c8\u30cb\u30f3\uff08PCT\uff09\u306e\u4f7f\u7528\u306f\u591a\u304f\u306e\u6ce8\u76ee\u3092\u96c6\u3081\u3066\u304a\u308a\u3001\u547c\u5438\u5668\u611f\u67d3\u75c7\u304a\u3088\u3073\u6557\u8840\u75c7\u3092\u6709\u3059\u308b\u60a3\u8005\u306b\u304a\u3051\u308b\u6297\u83cc\u7642\u6cd5\u306e\u30ac\u30a4\u30c0\u30f3\u30b9\u3068\u3057\u3066\u65e2\u306b\u627f\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002 PCT\u306f\u3001\u5065\u5eb7\u306a\u500b\u4f53\u3067\u306f\u691c\u51fa\u3067\u304d\u306a\u3044\u30ab\u30eb\u30b7\u30c8\u30cb\u30f3\u306e\u524d\u99c6\u4f53\u30db\u30eb\u30e2\u30f3\u3067\u3059\u3002\u3057\u304b\u3057\u3001PCT\u306e\u7523\u751f\u306f\u7d30\u83cc\u611f\u67d3\u306b\u53cd\u5fdc\u3057\u3066\u4ea2\u9032\u3057\u3001\u56de\u5fa9\u4e2d\u306b\u6025\u901f\u306b\u4f4e\u4e0b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \u3057\u305f\u304c\u3063\u3066\u3001PCT\u306f\u91cd\u8981\u306a\u8ffd\u52a0\u60c5\u5831\u3092\u63d0\u4f9b\u3057\u3001\u81e8\u5e8a\u7684\u30d1\u30e9\u30e1\u30fc\u30bf\u304a\u3088\u3073\u8a3a\u65ad\u30d1\u30e9\u30e1\u30fc\u30bf\u3092\u88dc\u5b8c\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u611f\u67d3\u307e\u305f\u306f\u6557\u8840\u75c7\u304c\u7591\u308f\u308c\u308b\u60a3\u8005\u306e\u6cbb\u7642\u306b\u95a2\u3059\u308b\u6c7a\u5b9a\u306b\u5927\u304d\u306a\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3060\u3051\u3067\u306a\u304f\u3001\u6297\u751f\u7269\u8cea\u6cbb\u7642\u30b3\u30fc\u30b9\u306e\u671f\u9593\u306b\u3082\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002PCT\u306e\u4f7f\u7528\u306f\u6557\u8840\u75c7\u306e\u7ba1\u7406\u306b\u304a\u3044\u3066\u9032\u5316\u3057\u3066\u304a\u308a\u3001\u3044\u304f\u3064\u304b\u306e\u4ecb\u5165\u7814\u7a76\u3068\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\u304c\u3001\u6297\u751f\u7269\u8cea\u306e\u4f7f\u7528\u304a\u3088\u3073\u5065\u5eb7\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u5bfe\u3059\u308bPCT\u30ac\u30a4\u30c9\u4ed8\u304d\u6226\u7565\u306e\u52b9\u679c\u3092\u5206\u6790\u30fb\u8981\u7d04\u3057\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u6557\u8840\u75c7\u306e\u72b6\u6cc1\u306b\u304a\u3051\u308bPCT\u306e\u6700\u9069\u306a\u4f7f\u7528\u306b\u95a2\u3059\u308b\u666e\u904d\u7684\u306a\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n

\u5065\u5eb7\u306a\u500b\u4f53\u3067\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u5168\u8eab\u6027\u708e\u75c7\u304c\u5b58\u5728\u3057\u306a\u3044\u5834\u5408\u306b\u306f\u8840\u6db2\u4e2d\u306b\u653e\u51fa\u3055\u308c\u306a\u3044\u305f\u3081\u3001\u8840\u6e05PCT\u306f\u691c\u51fa\u3067\u304d\u307e\u305b\u3093\u3002\u4e00\u65b9\u3001\u7d30\u83cc\u611f\u67d3\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u6557\u8840\u75c7\u306e\u5834\u5408\u3001PCT\u5408\u6210\u306f\u5b9f\u8cea\u7684\u306b\u3059\u3079\u3066\u306e\u7d44\u7e54\u3067\u8a98\u5c0e\u3055\u308c\u3001\u3057\u305f\u304c\u3063\u3066\u8840\u6db2\u4e2d\u3067\u691c\u51fa\u53ef\u80fd\u3068\u306a\u308a\u307e\u3059\u3002PCT\u5408\u6210\u306f\u3001\u30a8\u30f3\u30c9\u30c8\u30ad\u30b7\u30f3\u304a\u3088\u3073\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3\uff08IL\uff09-1\u03b2\u3001\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-6\u3001\u816b\u760d\u58ca\u6b7b\u56e0\u5b50\uff08TNF\uff09-\u03b1\u306a\u3069\u306e\u7d30\u83cc\u6bd2\u7d20\u3084\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u307e\u3059\u3002TNF-\u03b1\u306e\u7523\u751f\u3092\u963b\u5bb3\u3059\u308b\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u4e2d\u306b\u653e\u51fa\u3055\u308c\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u305f\u3081\u306b\u3001PCT\u5408\u6210\u306f\u307b\u3068\u3093\u3069\u306e\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u3067\u306f\u8a98\u5c0e\u3055\u308c\u307e\u305b\u3093\u3002\u3055\u3089\u306b\u3001PCT\u306f\u5e83\u3044\u751f\u7269\u5b66\u7684\u7bc4\u56f2\u3001\u7d30\u83cc\u523a\u6fc0\u5f8c\u306e\u8a98\u5c0e\u307e\u3067\u306e\u6642\u9593\u304c\u77ed\u3044\u3053\u3068\u3001\u534a\u6e1b\u671f\u304c\u9577\u3044\u3053\u3068\u304c\u7279\u5fb4\u3067\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001PCT\u306f\u7d30\u83cc\u6027\u708e\u75c7\u3068\u30a6\u30a4\u30eb\u30b9\u6027\u708e\u75c7\u306e\u533a\u5225\u306b\u304a\u3044\u3066\u826f\u597d\u306a\u8b58\u5225\u7279\u6027\u3092\u6709\u3057\u3001\u8fc5\u901f\u306b\u5229\u7528\u53ef\u80fd\u306a\u7d50\u679c\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002PCT\u81ea\u4f53\u306f\u7279\u5b9a\u306e\u75c5\u539f\u4f53\u3092\u5358\u96e2\u307e\u305f\u306f\u691c\u51fa\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u304c\u3001PCT\u306e\u30ec\u30d9\u30eb\u306f\u91cd\u5ea6\u306e\u7d30\u83cc\u611f\u67d3\u75c7\u306e\u78ba\u7387\u3092\u63a8\u5b9a\u3059\u308b\u306e\u306b\u6709\u7528\u3067\u3042\u308a\u5f97\u307e\u3059\u3002<\/p>\n

\u6570\u5341\u5e74\u306e\u7814\u7a76\u52aa\u529b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u5229\u7528\u53ef\u80fd\u306a\u6557\u8840\u75c7\u7279\u7570\u7684\u6cbb\u7642\u9078\u629e\u80a2\u306f\u4f9d\u7136\u3068\u3057\u3066\u5b58\u5728\u3057\u307e\u305b\u3093\u3002\u6297\u83cc\u85ac\u7642\u6cd5\u304a\u3088\u3073\u8f38\u6db2\u8607\u751f\u3092\u8fc5\u901f\u306b\u958b\u59cb\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u975e\u611f\u67d3\u6027\u306e\u539f\u56e0\u3068\u306e\u65e9\u671f\u8a3a\u65ad\u304a\u3088\u3073\u9451\u5225\u304c\u3001\u6cbb\u7642\u306e\u6210\u529f\u3068\u826f\u597d\u306a\u8ee2\u5e30\u306e\u305f\u3081\u306b\u6975\u3081\u3066\u91cd\u8981\u3067\u3059\u3002\u4e00\u65b9\u3001\u78ba\u5b9a\u7684\u307e\u305f\u306f\u7591\u308f\u3057\u3044\u6557\u8840\u75c7\u306e\u81e8\u5e8a\u5fb4\u5019\u306f\u4e0d\u5747\u4e00\u3067\u3042\u308a\u3001\u591a\u304f\u306e\u5834\u5408\u66d6\u6627\u3067\u3042\u308b\u305f\u3081\u3001\u305d\u306e\u8a3a\u65ad\u304a\u3088\u3073\u51e6\u7f6e\u306f\u4f9d\u7136\u3068\u3057\u3066\u56f0\u96e3\u306a\u307e\u307e\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002 \u4eca\u65e5\u307e\u3067\u3001\u8840\u6d41\u611f\u67d3\u75c7\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u6557\u8840\u75c7\u306e\u691c\u51fa\u306e\u305f\u3081\u306e\u30b4\u30fc\u30eb\u30c9\u30b9\u30bf\u30f3\u30c0\u30fc\u30c9\u306f\u5b58\u5728\u3057\u307e\u305b\u3093\u3002\u611f\u67d3\u307e\u305f\u306f\u6557\u8840\u75c7\u304c\u81e8\u5e8a\u7684\u306b\u7591\u308f\u308c\u308b\u60a3\u8005\u306b\u304a\u3051\u308b\u8840\u6db2\u57f9\u990a\u304a\u3088\u3073\u708e\u75c7\u6027\u8840\u6db2\u30de\u30fc\u30ab\u30fc\uff08C\u53cd\u5fdc\u6027\u30bf\u30f3\u30d1\u30af\u8cea\uff1aCRP\u3001\u767d\u8840\u7403\u6570\uff1aWBC\uff09\u306a\u3069\u306e\u5f93\u6765\u306e\u8a3a\u65ad\u30a2\u30d7\u30ed\u30fc\u30c1\u306e\u4f7f\u7528\u306b\u306f\u3001\u3044\u304f\u3064\u304b\u306e\u5236\u9650\u304c\u3042\u308a\u307e\u3059\u3002\u75c5\u539f\u4f53\u306e\u540c\u5b9a\u306e\u305f\u3081\u306e\u8840\u6db2\u57f9\u990a\u306e\u4f7f\u7528\u306f\u3001\u5fae\u751f\u7269\u306e\u7a2e\u985e\u304a\u3088\u3073\u6297\u751f\u7269\u8cea\u6cbb\u7642\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u306b\u95a2\u3059\u308b\u60c5\u5831\u3092\u63d0\u4f9b\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u5206\u6790\u3055\u308c\u305f\u57f9\u990a\u306e\u3054\u304f\u4e00\u90e8\u306e\u307f\u304c\u967d\u6027\u7d50\u679c\u3092\u793a\u3057\u3001\u5168\u8eab\u611f\u67d3\u304c\u7591\u308f\u308c\u305f\u60a3\u8005\u306e\u7d0440\uff5e90%\u3067\u306f\u3001\u7d50\u679c\u306f\u5897\u6b96\u3059\u308b\u75c5\u539f\u4f53\u3092\u793a\u3055\u306a\u3044\u9670\u6027\u8840\u6db2\u57f9\u990a\u3068\u306a\u308a\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u7d50\u679c\u304c\u51fa\u308b\u307e\u3067\u306e\u6642\u9593\u304c\u9577\u3044\u3068\u521d\u671f\u6cbb\u7642\u306e\u610f\u601d\u6c7a\u5b9a\u304c\u5236\u9650\u3055\u308c\u3001\u6c5a\u67d3\u306b\u3088\u3063\u3066\u5f97\u3089\u308c\u305f\u7d50\u679c\u306e\u7279\u7570\u6027\u304c\u6700\u9069\u4ee5\u4e0b\u306b\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u8a3a\u65ad\u30ef\u30fc\u30af\u30a2\u30c3\u30d7\u3092\u6539\u5584\u3059\u308b\u305f\u3081\u306b\u3001\u8ffd\u52a0\u306e\u691c\u67fb\u306f\u6709\u7528\u3067\u3042\u308a\u3001\u65e9\u671f\u306e\u4fe1\u983c\u3067\u304d\u308b\u8a3a\u65ad\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059[3]\u3002<\/p>\n

IL-6\u304a\u3088\u3073\u65b0\u751f\u5150\u6557\u8840\u75c7\u306b\u304a\u3051\u308b\u305d\u306e\u5f79\u5272<\/h2>\n

\u65b0\u751f\u5150\u6557\u8840\u75c7\u306f\u3001\u4e16\u754c\u4e2d\u3067\u5168\u969c\u5bb3\u8abf\u6574\u751f\u5b58\u5e74\u306e0.97%\u3092\u5360\u3081\u3001\u7d50\u8178\u30fb\u76f4\u8178\u304c\u3093\u3001\u5598\u606f\u3001\u4e73\u304c\u3093\u3088\u308a\u3082\u9ad8\u3044\u5272\u5408\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u65b0\u751f\u5150\u6557\u8840\u75c7\u306e\u6b7b\u4ea1\u7387\u306f11\uff5e19%2\u3068\u9ad8\u304f\u3001\u8133\u640d\u50b7\u3084\u5e7c\u5150\u671f\u306b\u304a\u3051\u308b\u795e\u7d4c\u767a\u9054\u30fb\u6210\u9577\u306e\u4e0d\u826f\u8ee2\u5e30\u3068\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u6709\u5bb3\u8ee2\u5e30\u3092\u9632\u3050\u306b\u306f\u3001\u65e9\u671f\u306e\u767a\u898b\u3068\u8fc5\u901f\u306a\u4ecb\u5165\u304c\u5fc5\u8981\u3067\u3059\u3002\u6557\u8840\u75c7\u306f\u611f\u67d3\u306b\u5bfe\u3059\u308b\u5168\u8eab\u6027\u708e\u75c7\u53cd\u5fdc\u3067\u3042\u308b\u305f\u3081\u3001\u8840\u6db2\u304b\u3089\u306e\u7d30\u83cc\u306e\u5358\u96e2\u304c\u30b4\u30fc\u30eb\u30c9\u30b9\u30bf\u30f3\u30c0\u30fc\u30c9\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u8d85\u4f4e\u51fa\u751f\u4f53\u91cd\u5150\uff08VLBW\u5150\u3001\u51fa\u751f\u4f53\u91cd<1500 g\uff09\u3067\u306f\u63a1\u53d6\u3067\u304d\u308b\u8840\u6db2\u91cf\u304c\u7d040.5\uff5e1 ml\u3068\u975e\u5e38\u306b\u5c11\u306a\u304f\u3001\u4f4e\u30ec\u30d9\u30eb\u83cc\u8840\u75c7\u306e\u5272\u5408\u304c\u9ad8\u304f\u3001\u8840\u6db2\u57f9\u990a\u304c\u967d\u6027\u306b\u306a\u308b\u307e\u3067\u6642\u9593\u304c\u304b\u304b\u308b\u3053\u3068\u304b\u3089\u3001\u30d7\u30ed\u30ab\u30eb\u30b7\u30c8\u30cb\u30f3\u3001\u30ea\u30dd\u591a\u7cd6\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u3001\u30d7\u30ec\u30bb\u30d7\u30b7\u30f3\u3001\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-6\u306a\u3069\u306e\u30d1\u30e9\u30e1\u30fc\u30bf\u304c\u3001\u65b0\u751f\u5150\u6557\u8840\u75c7\u306e\u8a3a\u65ad\u7cbe\u5ea6\u306b\u3064\u3044\u3066\u691c\u8a0e\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

IL-6\u306f\u3001\u514d\u75ab\u5fdc\u7b54\u3001\u9020\u8840\u3001\u6025\u6027\u671f\u53cd\u5fdc\u306b\u95a2\u4e0e\u3059\u308b\u591a\u6a5f\u80fd\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3067\u3059\u3002\u611f\u67d3\u306b\u5fdc\u7b54\u3057\u3066\u3001IL-6\u306fIgM\u3001IgG\u3001IgA\u7523\u751f\u304a\u3088\u3073\u30d8\u30eb\u30d1\u30fcT\u7d30\u80de\u306e\u5897\u6b96\u3092\u5897\u5f37\u3057\u3001\u5bbf\u4e3b\u9632\u5fa1\u6a5f\u69cb\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u30a8\u30f3\u30c9\u30c8\u30ad\u30b7\u30f3\u3078\u306e\u66dd\u9732\u5f8c\u3001IL-6\u6fc3\u5ea6\u306fC\u53cd\u5fdc\u6027\u30bf\u30f3\u30d1\u30af\u8cea\uff08CRP\uff09\u306a\u3069\u306e\u6025\u6027\u671f\u53cd\u5fdc\u7269\u8cea\u306b\u5148\u7acb\u3063\u3066\u4e0a\u6607\u3057\u307e\u3059\u3002IL-6\u306f\u81cd\u5e2f\u8840\u307e\u305f\u306f\u8840\u6e05\u4e2d\u3067\u6e2c\u5b9a\u3055\u308c\u3001\u8a3a\u65ad\u7cbe\u5ea6\u304c\u7570\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u81cd\u5e2f\u8840IL-6\u306f\u3001\u65e9\u671f\u767a\u75c7\u6557\u8840\u75c7\u306b\u5bfe\u3057\u306687\uff5e100%\u306e\u611f\u5ea6\u3092\u793a\u3057\u307e\u3059\u3002\u8840\u6e05IL-6\u306f\u3001\u65e9\u767a\u578b\u6557\u8840\u75c7\u306e\u8a3a\u65ad\u306b\u5bfe\u3057\u306675\uff5e85%\u306e\u611f\u5ea6\u304a\u3088\u307372.8\uff5e88%\u306e\u7279\u7570\u5ea6\u3092\u6709\u3057\u3001\u9045\u767a\u578b\u6557\u8840\u75c7\u306b\u5bfe\u3057\u306680\uff5e93.8%\u306e\u611f\u5ea6\u304a\u3088\u307380\uff5e96%\u306e\u7279\u7570\u5ea6\u3092\u793a\u3057\u3001CRP\u3092\u4e0a\u56de\u308a\u307e\u3059\u3002\u6297\u751f\u7269\u8cea\u6cbb\u7642\u4e2d\u3001\u8840\u6e05IL-6\u6fc3\u5ea6\u306f\u6025\u901f\u306b\u691c\u51fa\u4e0d\u80fd\u306a\u5024\u306b\u4f4e\u4e0b\u3057\u307e\u3059\u3002IL-6\u306e\u9ad8\u3044\u611f\u5ea6\u304a\u3088\u3073\u9670\u6027\u7684\u4e2d\u7387\u306f\u3001\u9ad8\u7279\u7570\u5ea6\u306eCRP\u3068\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001\u65b0\u751f\u5150\u6557\u8840\u75c7\u3092\u8a3a\u65ad\u3059\u308b\u305f\u3081\u306e\u6709\u671b\u306a\u5019\u88dc\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n

\"\"<\/p>\n

\u56f31\uff1a\u6557\u8840\u75c7\u306b\u304a\u3051\u308b\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3\u20136\u304a\u3088\u3073C\u53cd\u5fdc\u6027\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u305d\u306e\u7d4c\u6642\u7684\u5909\u53161\u65e5\u76ee\uff08a\uff09\u304a\u3088\u30737\u65e5\u76ee\u4ee5\u964d\uff08b\uff09\u306e\u57f9\u990a\u78ba\u8a8d\u6557\u8840\u75c7\u306b\u304a\u3051\u308b\u8840\u6e05\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3\u20136\u304a\u3088\u3073C\u53cd\u5fdc\u6027\u30bf\u30f3\u30d1\u30af\u8cea\uff08CRP\uff09\u3002<\/em><\/p>\n

\u56f31\u306b\u793a\u3059\u3088\u3046\u306b\u3001\u8840\u6e05IL-6\u306f\u51fa\u751f1\u65e5\u76ee\uff08DOL1\uff09\u306e\u57f9\u990a\u78ba\u8a8d\u6557\u8840\u75c7\u3067\u975e\u5e38\u306b\u65e9\u671f\u304b\u3089\u4e0a\u6607\u3057\u307e\u3059\u304c\u3001CRP\u304c\u30d4\u30fc\u30af\u306b\u9054\u3059\u308b\u306b\u306f\u7d0448\u6642\u9593\u3092\u8981\u3057\u307e\u3059\u3002\u8840\u6e05IL-6\u306e\u9ad8\u3044\u7cbe\u5ea6\u306b\u57fa\u3065\u304d\u3001DOL1\u3067\u6e2c\u5b9a\u3055\u308c\u305fIL-6\u306f\u5148\u5929\u6027\u6557\u8840\u75c7\u306e\u8a3a\u65ad\u306b\u6975\u3081\u3066\u6709\u7528\u3067\u3042\u308b\u3068\u7d50\u8ad6\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u56f31\u306b\u793a\u3059\u3088\u3046\u306b\u3001\u8840\u6e05IL-6\u306f\u3001DOL7\u4ee5\u964d\u306e\u57f9\u990a\u78ba\u8a8d\u6557\u8840\u75c7\u306e\u30a8\u30d4\u30bd\u30fc\u30c9\u306b\u304a\u3044\u3066\u3001CRP\u3088\u308a24\uff5e48\u6642\u9593\u65e9\u304f\u4e0a\u6607\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u8840\u6e05IL-6\u306f\u3001\u751f\u5f8c1\u9031\u9593\u4ee5\u964d\u306b\u767a\u75c7\u3059\u308b\u6557\u8840\u75c7\u75c7\u4f8b\u3067\u6700\u3082\u65e9\u671f\u306b\u4e0a\u6607\u3059\u308b\u6700\u3082\u6b63\u78ba\u306a\u691c\u67fb\u5ba4\u30d1\u30e9\u30e1\u30fc\u30bf\u3068\u306a\u308a\u307e\u3059\u3002Tzialla\u3089\u306f\u3001\u6025\u6027\u671f\u53cd\u5fdc\u7269\u8cea\u306b\u5148\u7acb\u3063\u3066\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u30ec\u30d9\u30eb\u304c\u6025\u901f\u306b\u5909\u5316\u3059\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u8840\u6e05IL-6\u306e\u7cbe\u5ea6\u306f\u9ad8\u304f\u3001\u3068\u308a\u308f\u3051\u9670\u6027\u7684\u4e2d\u7387\u304c\u975e\u5e38\u306b\u9ad8\u3044\u3053\u3068\u304b\u3089\u3001\u8840\u6e05IL-6\u306f\u65b0\u751f\u5150\u3084\u65e9\u7523\u5150\u306e\u6557\u8840\u75c7\u8a3a\u65ad\u306b\u6709\u7528\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u3055\u3089\u306b\u3001IL-6\u306f\u52b9\u679c\u7684\u306a\u6297\u751f\u7269\u8cea\u6cbb\u7642\u958b\u59cb\u5f8c\u306b\u6025\u901f\u306b\u4f4e\u4e0b\u3057\u3001\u6297\u751f\u7269\u8cea\u6cbb\u7642\u306e\u8fc5\u901f\u306a\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u3084\u3001\u6cbb\u7642\u306e\u9069\u6642\u306a\u6f38\u5897\u30fb\u6f38\u6e1b\u3092\u53ef\u80fd\u306b\u3057\u307e\u3059[4]\u3002<\/p>\n

\u7d50\u8ad6<\/h2>\n

\u6557\u8840\u75c7\u306f\u751f\u547d\u3092\u8105\u304b\u3059\u75be\u60a3\u3067\u3042\u308a\u3001ICU\u5165\u9662\u60a3\u8005\u306e\u6700\u3082\u4e00\u822c\u7684\u306a\u539f\u56e0\u306e1\u3064\u3067\u3059\u3002\u6557\u8840\u75c7\u306e\u6b7b\u4ea1\u7387\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u306b\u306f\u3001\u65e9\u671f\u8a3a\u65ad\u304a\u3088\u3073\u9069\u5207\u306a\u7ba1\u7406\u304c\u5fc5\u8981\u3067\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u611f\u67d3\u75c7\u306b\u5bfe\u3059\u308b\u751f\u7406\u53cd\u5fdc\u306f\u500b\u4f53\u5dee\u304c\u5927\u304d\u304f\u3001\u307e\u305f\u6557\u8840\u75c7\u306e\u5fb4\u5019\u3084\u75c7\u72b6\u3082\u975e\u7279\u7570\u7684\u3067\u3042\u308b\u305f\u3081\u3001\u65e9\u671f\u8a3a\u65ad\u306f\u56f0\u96e3\u3067\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u6557\u8840\u75c7\u306e\u8a3a\u65ad\u306e\u305f\u3081\u306e\u591a\u304f\u306e\u6f5c\u5728\u7684\u306a\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u304c\u8abf\u67fb\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u5206\u5b50\u306f\u4e3b\u306b\u611f\u67d3\u306b\u5bfe\u3059\u308b\u81ea\u7136\u514d\u75ab\u5fdc\u7b54\u306e\u521d\u671f\u75c5\u614b\u5f62\u6210\u306b\u95a2\u4e0e\u3057\u3001\u591a\u304f\u306e\u5834\u5408\u3001\u4e88\u5f8c\u7684\u4fa1\u5024\u4e26\u3073\u306b\u8a3a\u65ad\u7684\u4fa1\u5024\u3092\u793a\u3057\u307e\u3059\u3002\u6557\u8840\u75c7\u306e\u4e88\u5f8c\u30de\u30fc\u30ab\u30fc\u306f\u3001\u6557\u8840\u75c7\u306b\u3088\u308b\u81d3\u5668\u6a5f\u80fd\u4e0d\u5168\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u591a\u304f\u3001\u3053\u308c\u3089\u306e\u4e88\u5f8c\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3092\u6a19\u7684\u3068\u3059\u308b\u6557\u8840\u75c7\u6cbb\u7642\u85ac\u306e\u958b\u767a\u304c\u8a66\u307f\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u6280\u8853\u306e\u6700\u8fd1\u306e\u9032\u6b69\u306f\u3001\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\u304a\u3088\u3073\u975e\u30b3\u30fc\u30c9RNA\u306a\u3069\u306e\u65b0\u3057\u3044\u30bf\u30a4\u30d7\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u958b\u767a\u3092\u3082\u305f\u3089\u3057\u307e\u3057\u305f\u3002\u8178\u5185\u5fae\u751f\u7269\u53e2\u306f\u3001\u514d\u75ab\u7cfb\u306e\u767a\u9054\u3068\u6210\u719f\u3001\u304a\u3088\u3073\u75c5\u539f\u4f53\u306b\u5bfe\u3059\u308b\u4fdd\u8b77\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u8178\u5185\u6bd2\u7d20\u75c7\u306f\u3001\u6557\u8840\u75c7\u306e\u767a\u75c7\u304a\u3088\u3073\u9032\u884c\u306b\u95a2\u3059\u308b\u5f37\u529b\u306a\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002miRNA\u3092\u542b\u3080\u975e\u30b3\u30fc\u30c9RNA\u304a\u3088\u3073\u9577\u3044\u975e\u30b3\u30fc\u30c9RNA\u306f\u3001\u69d8\u3005\u306a\u65b9\u6cd5\u3067\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u8abf\u7bc0\u3057\u307e\u3059\u304c\u3001\u6557\u8840\u75c7\u306e\u75c5\u56e0\u306b\u304a\u3051\u308b\u305d\u308c\u3089\u306e\u6a5f\u80fd\u304a\u3088\u3073\u6a5f\u69cb\u306f\u5b8c\u5168\u306b\u306f\u7406\u89e3\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n

\u6557\u8840\u75c7\u306e\u767a\u75c7\u6a5f\u5e8f\u306b\u304a\u3051\u308b\u3053\u308c\u3089\u306e\u65b0\u3057\u3044\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u5f79\u5272\u3001\u4e26\u3073\u306b\u3053\u308c\u3089\u306e\u65b0\u3057\u3044\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3092\u5206\u6790\u3059\u308b\u305f\u3081\u306e\u6700\u9069\u306a\u6b63\u898f\u5316\u6226\u7565\u306e\u958b\u767a\u306b\u95a2\u3059\u308b\u66f4\u306a\u308b\u8a55\u4fa1\u304c\u3001\u305d\u308c\u3089\u306e\u5c06\u6765\u306e\u81e8\u5e8a\u4f7f\u7528\u306e\u305f\u3081\u306b\u5fc5\u8981\u3068\u3055\u308c\u308b\u3067\u3057\u3087\u3046[5]\u3002<\/p>\n

\u53c2\u8003\u6587\u732e\uff1a<\/em><\/p>\n

[1]<\/a>Sepsis Clinical Care Standard 2022<\/p>\n

[2]<\/a> Global Burden of Disease study<\/p>\n

[3]<\/a>\u00a0Gregoriano, C.et al. (2020) \u2018Role of procalcitonin use in the management of sepsis\u2019, Journal of Thoracic Disease, 12(S1). doi:10.21037\/jtd.2019.11.63.<\/p>\n

[4]<\/a>\u00a0K\u00fcng, E.et al. (2022) \u2018Cut-off values of serum interleukin-6 for culture-confirmed sepsis in neonates\u2019, Pediatric Research, 93(7), pp. 1969\u20131974. doi:10.1038\/s41390-022-02329-9.<\/p>\n

[5]\u00a0Kim, M.-H. and Choi, J.-H. (2020) \u2019An update on sepsis biomarkers\u2019, Infection & Chemotherapy, 52(1), p. 1.doi:10.3947\/ic.2020.52.1.1.<\/p>\n

\n

\u3053\u306e\u8a18\u4e8b\u306fRoche Diagnostics Australia\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f<\/a>\u3002<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

\u7b2c\u4e09\u56de\u6557\u8840\u75c7\u304a\u3088\u3073\u6557\u8840\u75c7\u6027\u30b7\u30e7\u30c3\u30af\u306e\u56fd\u969b\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9\u5b9a\u7fa9\uff08Sepsis-3\uff09\u306f\u3001\u6557\u8840\u75c7\u3092\u300c\u611f\u67d3\u306b\u5bfe\u3059\u308b\u8abf\u7bc0\u4e0d\u5168\u306e\u5bbf\u4e3b\u5fdc\u7b54\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u751f\u547d\u3092\u8105\u304b\u3059\u81d3\u5668\u6a5f\u80fd\u4e0d\u5168\u300d\u3068\u5b9a\u7fa9\u3057\u3066\u3044\u307e\u3059\u3002 \u6557\u8840\u75c7\u6027\u30b7\u30e7\u30c3\u30af\u306f\u3001\u300c\u57fa\u790e\u306b\u3042\u308b\u5faa\u74b0\u7570\u5e38\u3001\u7d30\u80de\u7570\u5e38\u304a\u3088\u3073\u4ee3\u8b1d\u7570\u5e38\u304c\u3001\u6557\u8840\u75c7\u5358\u72ec\u3088\u308a\u3082\u6b7b\u4ea1\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u6557\u8840\u75c7\u306e\u30b5\u30d6\u30bb\u30c3\u30c8\u300d\u3068\u3057\u3066\u5b9a\u7fa9\u3055\u308c\u307e\u3059\u3002 \u6557\u8840\u75c7\u306f\u3001\u5358\u4e00\u306e\u8a3a\u65ad\u691c\u67fb\u304c\u306a\u3044\u305f\u3081\u81e8\u5e8a\u8a3a\u65ad\u3068\u306a\u308a\u307e\u3059\u3002\u751f\u7406\u5b66\u7684\u7570\u5e38\u304a\u3088\u3073\u691c\u67fb\u7570\u5e38\u306e\u4e21\u65b9\u304c\u5b58\u5728\u3057\u5f97\u307e\u3059\u3002Sepsis-3\u306f\u3001\u300c\u91cd\u75c7\u6557\u8840\u75c7\u300d\u3068\u3044\u3046\u7528\u8a9e\u3092\u6392\u9664\u3057\u3001\u4ee3\u308f\u308a\u306b\u300c\u6557\u8840\u75c7\u6027\u30b7\u30e7\u30c3\u30af\u300d\u304a\u3088\u3073\u300c\u6557\u8840\u75c7\u300d\u3092\u5b9a\u7fa9\u30fb\u5c64\u5225\u5316\u3057\u3001\u6557\u8840\u75c7\u60a3\u8005\u306e\u3088\u308a\u65e9\u671f\u306e\u8a8d\u8b58\u304a\u3088\u3073\u3088\u308a\u30bf\u30a4\u30e0\u30ea\u30fc\u306a\u7ba1\u7406\u3092\u5bb9\u6613\u306b\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u307e\u3057\u305f\u3002\u6557\u8840\u75c7\u306f\u91cd\u75c7\u5ea6\u306e\u30b9\u30da\u30af\u30c8\u30eb\u3068\u3057\u3066\u73fe\u308c\u307e\u3059\u3002\u8a3a\u65ad\u306f\u4e0d\u78ba\u304b\u306a\u53ef\u80fd\u6027\u3082\u3042\u308b\u304c\u3001\u6557\u8840\u75c7\u3092\u6709\u3059\u308b\u3059\u3079\u3066\u306e\u60a3\u8005\u306b\u304a\u3044\u3066\u6025\u901f\u304b\u3064\u91cd\u7be4\u306a\u60aa\u5316\u306e\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u6557\u8840\u75c7\u306e\u53ef\u80fd\u6027\u304c\u3042\u308b\u5834\u5408\u306f\u5e38\u306b\u4ecb\u5165\u304c\u5fc5\u8981\u3067\u3059[1]\u3002 \u300cGlobal Burden of Disease\u300d\u306e\u7814\u7a76\u3067\u306f\u3001195\u306e\u56fd\u3068\u5730\u57df\u306b\u304a\u3051\u308b1\u5104900\u4e07\u4ef6\u306e\u6b7b\u4ea1\u8a18\u9332\u3068860\u4e07\u4ef6\u306e\u75c5\u9662\u8a18\u9332\u306e\u30c7\u30fc\u30bf\u3092\u7528\u3044\u3066\u3001\u4e16\u754c\u4e2d\u306e\u6557\u8840\u75c7\u306e\u8ca0\u62c5\u3092\u63a8\u5b9a\u3057\u307e\u3057\u305f\u30022017\u5e74\u306b\u306f\u6557\u8840\u75c7\u306e\u75c7\u4f8b\u304c4,900\u4e07\u4ef6\u3001\u6b7b\u4ea1\u4f8b\u304c1,100\u4e07\u4ef6\u3068\u3001\u3053\u308c\u307e\u3067\u306e\u63a8\u5b9a\u306e2\u500d\u3067\u3042\u308a\u3001\u4e16\u754c\u4e2d\u3067\u6557\u8840\u75c7\u306b\u95a2\u9023\u3059\u308b\u6b7b\u4ea1\u4f8b\u306f5\u4f8b\u4e2d1\u4f8b\u306b\u4e0a\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u307e\u3057\u305f\u3002\u591a\u304f\u306e\u4eba\u304c\u9632\u3050\u3053\u3068\u304c\u3067\u304d\u308b\u72b6\u614b\u3067\u4ea1\u304f\u306a\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u554f\u984c\u3067\u3057\u305f\u3002\u30aa\u30fc\u30b9\u30c8\u30e9\u30ea\u30a2\u306b\u304a\u3051\u308b\u6557\u8840\u75c7\u306e\u8ca0\u62c5\u306b\u95a2\u3059\u308b\u4ee5\u524d\u306e\u63a8\u5b9a\u5024\u306f\u3001\u4e3b\u306b\u96c6\u4e2d\u6cbb\u7642\u5ba4\u3067\u6cbb\u7642\u3055\u308c\u305f\u75c7\u4f8b\u3092\u57fa\u306b\u3057\u3066\u304a\u308a\u3001\u75c7\u4f8b\u6570\u306f18,000\u4eba\u3001\u6b7b\u4ea1\u8005\u6570\u306f5,000\u4eba\u3067\u3057\u305f\u3002 \u3057\u304b\u3057\u3001\u5148\u8ff0\u306e\u300cGlobal Burden of Disease\u300d\u306e\u7814\u7a76\u306b\u3088\u308b\u63a8\u5b9a\u3067\u306f\u3001\u75c5\u9662\u5916\u3067\u767a\u751f\u3059\u308b\u6557\u8840\u75c7\u3092\u542b\u3081\u3001\u30aa\u30fc\u30b9\u30c8\u30e9\u30ea\u30a2\u3067\u306e\u75c7\u4f8b\u6570\u306f55,000\u4f8b\u3001\u6b7b\u4ea1\u8005\u6570\u306f8,700\u4f8b\u3068\u306a\u308a\u3001\u554f\u984c\u306e\u898f\u6a21\u306b\u3064\u3044\u3066\u3088\u308a\u6b63\u78ba\u306a\u5168\u4f53\u50cf\u304c\u5f97\u3089\u308c\u3066\u3044\u307e\u3059\u3002 \u6557\u8840\u75c7\u306f\u3001\u611f\u67d3\u306b\u5bfe\u3059\u308b\u8eab\u4f53\u306e\u5fdc\u7b54\u304c\u81ea\u8eab\u306e\u7d44\u7e54\u304a\u3088\u3073\u5668\u5b98\u3092\u640d\u50b7\u3059\u308b\u3068\u304d\u306b\u767a\u751f\u3059\u308b\u3001\u6642\u9593\u7684\u306b\u91cd\u8981\u306a\u533b\u5b66\u7684\u7dca\u6025\u4e8b\u614b\u3067\u3059\u3002\u65e9\u671f\u306b\u767a\u898b\u3055\u308c\u305a\u8fc5\u901f\u306a\u6cbb\u7642\u304c\u884c\u308f\u308c\u306a\u3051\u308c\u3070\u3001\u30b7\u30e7\u30c3\u30af\u3084\u591a\u81d3\u5668\u4e0d\u5168\u304c\u751f\u3058\u3001\u6b7b\u306b\u81f3\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002\u6557\u8840\u75c7\u306f\u3042\u3089\u3086\u308b\u5e74\u9f62\u5c64\u3001\u5e45\u5e83\u3044\u81e8\u5e8a\u5206\u91ce\u306e\u60a3\u8005\u306b\u767a\u751f\u3057\u307e\u3059\u304c\u3001\u7279\u306b\u975e\u5e38\u306b\u82e5\u3044\u4eba\u3001\u975e\u5e38\u306b\u9ad8\u9f62\u306e\u4eba\u3001\u30a2\u30dc\u30ea\u30b8\u30cb\u3084\u30c8\u30ec\u30b9\u6d77\u5ce1\u8af8\u5cf6\u6c11\u306e\u767a\u751f\u304c\u76ee\u7acb\u3061\u307e\u3059\u3002\u3057\u304b\u3057\u30012016\u5e74\u306e\u8abf\u67fb\u306b\u3088\u308b\u3068\u3001\u30aa\u30fc\u30b9\u30c8\u30e9\u30ea\u30a2\u4eba\u306e60%\u304c\u6557\u8840\u75c7\u3092\u805e\u3044\u305f\u3053\u3068\u304c\u306a\u304f\u300114%\u3057\u304b\u75c7\u72b6\u306e1\u3064\u3092\u6319\u3052\u308b\u3053\u3068\u304c\u3067\u304d\u306a\u304b\u3063\u305f\u305f\u3081\u3001\u75c5\u6c17\u306b\u5bfe\u3059\u308b\u610f\u8b58\u306f\u4f4e\u3044\u72b6\u6cc1\u3067\u3059\u3002\u307e\u305f\u3001\u6557\u8840\u75c7\u306b\u3088\u308b\u91cd\u5927\u306a\u6b7b\u4ea1\u3068\u969c\u5bb3\u306b\u5bfe\u51e6\u3059\u308b\u305f\u3081\u306b\u3001\u5165\u9662\u524d\u3068\u5165\u9662\u4e2d\u306e\u8a8d\u8b58\u304a\u3088\u3073\u6cbb\u7642\u306b\u53d6\u308a\u7d44\u3080\u5354\u8abf\u7684\u306a\u56fd\u5bb6\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u5fc5\u8981\u3067\u3059[2]\u3002 \u6557\u8840\u75c7\u306e\u7ba1\u7406\u306b\u304a\u3051\u308b\u30d7\u30ed\u30ab\u30eb\u30b7\u30c8\u30cb\u30f3\u306e\u5f79\u5272 \u91cd\u75c7\u611f\u67d3\u75c7\u304a\u3088\u3073\u6557\u8840\u75c7\u3092\u6709\u3059\u308b\u91cd\u75c7\u60a3\u8005\u306e\u81e8\u5e8a\u7ba1\u7406\u306f\u3001\u8a3a\u65ad\u304a\u3088\u3073\u51e6\u7f6e\u306e\u6c7a\u5b9a\u307e\u3067\u306e\u6642\u9593\u3092\u77ed\u7e2e\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u6539\u5584\u3067\u304d\u307e\u3059\uff08\u3059\u306a\u308f\u3061\u3001\u7d30\u83cc\u611f\u67d3\u5bfe\u771f\u83cc\u611f\u67d3\u5bfe\u975e\u611f\u67d3\u75c5\u56e0\u306e\u533a\u5225\uff09\u3002\u3055\u3089\u306b\u3001\u65e9\u671f\u30ea\u30b9\u30af\u5c64\u5225\u5316\u304a\u3088\u3073\u4e88\u5f8c\u60c5\u5831\u306e\u63d0\u4f9b\u306b\u3088\u308a\u3001\u533b\u7642\u73fe\u5834\u306e\u610f\u601d\u6c7a\u5b9a\u3092\u6539\u5584\u3067\u304d\u307e\u3059\uff08\u4f8b\uff1a\u65e9\u671f\u9000\u9662\u307e\u305f\u306f\u30b1\u30a2\u306e\u6f38\u5897\uff09\u3002\u7e70\u308a\u8fd4\u3057\u6e2c\u5b9a\u3059\u308b\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306f\u307e\u305f\u3001\u60a3\u8005\u306e\u500b\u3005\u306e\u30cb\u30fc\u30ba\u306b\u5408\u308f\u305b\u3066\u6cbb\u7642\u3092\u8abf\u6574\u3059\u308b\u305f\u3081\u306e\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u306b\u3082\u5f79\u7acb\u3061\u307e\u3059\uff08\u6297\u751f\u7269\u8cea\u306e\u7ba1\u7406\uff09\u3002\u3053\u308c\u306b\u95a2\u9023\u3057\u3066\u3001\u5bbf\u4e3b\u5fdc\u7b54\u304a\u3088\u3073\u8840\u6db2\u611f\u67d3\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b\u30d7\u30ed\u30ab\u30eb\u30b7\u30c8\u30cb\u30f3\uff08PCT\uff09\u306e\u4f7f\u7528\u306f\u591a\u304f\u306e\u6ce8\u76ee\u3092\u96c6\u3081\u3066\u304a\u308a\u3001\u547c\u5438\u5668\u611f\u67d3\u75c7\u304a\u3088\u3073\u6557\u8840\u75c7\u3092\u6709\u3059\u308b\u60a3\u8005\u306b\u304a\u3051\u308b\u6297\u83cc\u7642\u6cd5\u306e\u30ac\u30a4\u30c0\u30f3\u30b9\u3068\u3057\u3066\u65e2\u306b\u627f\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002 PCT\u306f\u3001\u5065\u5eb7\u306a\u500b\u4f53\u3067\u306f\u691c\u51fa\u3067\u304d\u306a\u3044\u30ab\u30eb\u30b7\u30c8\u30cb\u30f3\u306e\u524d\u99c6\u4f53\u30db\u30eb\u30e2\u30f3\u3067\u3059\u3002\u3057\u304b\u3057\u3001PCT\u306e\u7523\u751f\u306f\u7d30\u83cc\u611f\u67d3\u306b\u53cd\u5fdc\u3057\u3066\u4ea2\u9032\u3057\u3001\u56de\u5fa9\u4e2d\u306b\u6025\u901f\u306b\u4f4e\u4e0b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \u3057\u305f\u304c\u3063\u3066\u3001PCT\u306f\u91cd\u8981\u306a\u8ffd\u52a0\u60c5\u5831\u3092\u63d0\u4f9b\u3057\u3001\u81e8\u5e8a\u7684\u30d1\u30e9\u30e1\u30fc\u30bf\u304a\u3088\u3073\u8a3a\u65ad\u30d1\u30e9\u30e1\u30fc\u30bf\u3092\u88dc\u5b8c\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u611f\u67d3\u307e\u305f\u306f\u6557\u8840\u75c7\u304c\u7591\u308f\u308c\u308b\u60a3\u8005\u306e\u6cbb\u7642\u306b\u95a2\u3059\u308b\u6c7a\u5b9a\u306b\u5927\u304d\u306a\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3060\u3051\u3067\u306a\u304f\u3001\u6297\u751f\u7269\u8cea\u6cbb\u7642\u30b3\u30fc\u30b9\u306e\u671f\u9593\u306b\u3082\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002PCT\u306e\u4f7f\u7528\u306f\u6557\u8840\u75c7\u306e\u7ba1\u7406\u306b\u304a\u3044\u3066\u9032\u5316\u3057\u3066\u304a\u308a\u3001\u3044\u304f\u3064\u304b\u306e\u4ecb\u5165\u7814\u7a76\u3068\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\u304c\u3001\u6297\u751f\u7269\u8cea\u306e\u4f7f\u7528\u304a\u3088\u3073\u5065\u5eb7\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u5bfe\u3059\u308bPCT\u30ac\u30a4\u30c9\u4ed8\u304d\u6226\u7565\u306e\u52b9\u679c\u3092\u5206\u6790\u30fb\u8981\u7d04\u3057\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u6557\u8840\u75c7\u306e\u72b6\u6cc1\u306b\u304a\u3051\u308bPCT\u306e\u6700\u9069\u306a\u4f7f\u7528\u306b\u95a2\u3059\u308b\u666e\u904d\u7684\u306a\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9\u306f\u3042\u308a\u307e\u305b\u3093\u3002 \u5065\u5eb7\u306a\u500b\u4f53\u3067\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u5168\u8eab\u6027\u708e\u75c7\u304c\u5b58\u5728\u3057\u306a\u3044\u5834\u5408\u306b\u306f\u8840\u6db2\u4e2d\u306b\u653e\u51fa\u3055\u308c\u306a\u3044\u305f\u3081\u3001\u8840\u6e05PCT\u306f\u691c\u51fa\u3067\u304d\u307e\u305b\u3093\u3002\u4e00\u65b9\u3001\u7d30\u83cc\u611f\u67d3\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u6557\u8840\u75c7\u306e\u5834\u5408\u3001PCT\u5408\u6210\u306f\u5b9f\u8cea\u7684\u306b\u3059\u3079\u3066\u306e\u7d44\u7e54\u3067\u8a98\u5c0e\u3055\u308c\u3001\u3057\u305f\u304c\u3063\u3066\u8840\u6db2\u4e2d\u3067\u691c\u51fa\u53ef\u80fd\u3068\u306a\u308a\u307e\u3059\u3002PCT\u5408\u6210\u306f\u3001\u30a8\u30f3\u30c9\u30c8\u30ad\u30b7\u30f3\u304a\u3088\u3073\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3\uff08IL\uff09-1\u03b2\u3001\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-6\u3001\u816b\u760d\u58ca\u6b7b\u56e0\u5b50\uff08TNF\uff09-\u03b1\u306a\u3069\u306e\u7d30\u83cc\u6bd2\u7d20\u3084\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u307e\u3059\u3002TNF-\u03b1\u306e\u7523\u751f\u3092\u963b\u5bb3\u3059\u308b\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u4e2d\u306b\u653e\u51fa\u3055\u308c\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u305f\u3081\u306b\u3001PCT\u5408\u6210\u306f\u307b\u3068\u3093\u3069\u306e\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u3067\u306f\u8a98\u5c0e\u3055\u308c\u307e\u305b\u3093\u3002\u3055\u3089\u306b\u3001PCT\u306f\u5e83\u3044\u751f\u7269\u5b66\u7684\u7bc4\u56f2\u3001\u7d30\u83cc\u523a\u6fc0\u5f8c\u306e\u8a98\u5c0e\u307e\u3067\u306e\u6642\u9593\u304c\u77ed\u3044\u3053\u3068\u3001\u534a\u6e1b\u671f\u304c\u9577\u3044\u3053\u3068\u304c\u7279\u5fb4\u3067\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001PCT\u306f\u7d30\u83cc\u6027\u708e\u75c7\u3068\u30a6\u30a4\u30eb\u30b9\u6027\u708e\u75c7\u306e\u533a\u5225\u306b\u304a\u3044\u3066\u826f\u597d\u306a\u8b58\u5225\u7279\u6027\u3092\u6709\u3057\u3001\u8fc5\u901f\u306b\u5229\u7528\u53ef\u80fd\u306a\u7d50\u679c\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002PCT\u81ea\u4f53\u306f\u7279\u5b9a\u306e\u75c5\u539f\u4f53\u3092\u5358\u96e2\u307e\u305f\u306f\u691c\u51fa\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u304c\u3001PCT\u306e\u30ec\u30d9\u30eb\u306f\u91cd\u5ea6\u306e\u7d30\u83cc\u611f\u67d3\u75c7\u306e\u78ba\u7387\u3092\u63a8\u5b9a\u3059\u308b\u306e\u306b\u6709\u7528\u3067\u3042\u308a\u5f97\u307e\u3059\u3002 \u6570\u5341\u5e74\u306e\u7814\u7a76\u52aa\u529b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u5229\u7528\u53ef\u80fd\u306a\u6557\u8840\u75c7\u7279\u7570\u7684\u6cbb\u7642\u9078\u629e\u80a2\u306f\u4f9d\u7136\u3068\u3057\u3066\u5b58\u5728\u3057\u307e\u305b\u3093\u3002\u6297\u83cc\u85ac\u7642\u6cd5\u304a\u3088\u3073\u8f38\u6db2\u8607\u751f\u3092\u8fc5\u901f\u306b\u958b\u59cb\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u975e\u611f\u67d3\u6027\u306e\u539f\u56e0\u3068\u306e\u65e9\u671f\u8a3a\u65ad\u304a\u3088\u3073\u9451\u5225\u304c\u3001\u6cbb\u7642\u306e\u6210\u529f\u3068\u826f\u597d\u306a\u8ee2\u5e30\u306e\u305f\u3081\u306b\u6975\u3081\u3066\u91cd\u8981\u3067\u3059\u3002\u4e00\u65b9\u3001\u78ba\u5b9a\u7684\u307e\u305f\u306f\u7591\u308f\u3057\u3044\u6557\u8840\u75c7\u306e\u81e8\u5e8a\u5fb4\u5019\u306f\u4e0d\u5747\u4e00\u3067\u3042\u308a\u3001\u591a\u304f\u306e\u5834\u5408\u66d6\u6627\u3067\u3042\u308b\u305f\u3081\u3001\u305d\u306e\u8a3a\u65ad\u304a\u3088\u3073\u51e6\u7f6e\u306f\u4f9d\u7136\u3068\u3057\u3066\u56f0\u96e3\u306a\u307e\u307e\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002 \u4eca\u65e5\u307e\u3067\u3001\u8840\u6d41\u611f\u67d3\u75c7\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u6557\u8840\u75c7\u306e\u691c\u51fa\u306e\u305f\u3081\u306e\u30b4\u30fc\u30eb\u30c9\u30b9\u30bf\u30f3\u30c0\u30fc\u30c9\u306f\u5b58\u5728\u3057\u307e\u305b\u3093\u3002\u611f\u67d3\u307e\u305f\u306f\u6557\u8840\u75c7\u304c\u81e8\u5e8a\u7684\u306b\u7591\u308f\u308c\u308b\u60a3\u8005\u306b\u304a\u3051\u308b\u8840\u6db2\u57f9\u990a\u304a\u3088\u3073\u708e\u75c7\u6027\u8840\u6db2\u30de\u30fc\u30ab\u30fc\uff08C\u53cd\u5fdc\u6027\u30bf\u30f3\u30d1\u30af\u8cea\uff1aCRP\u3001\u767d\u8840\u7403\u6570\uff1aWBC\uff09\u306a\u3069\u306e\u5f93\u6765\u306e\u8a3a\u65ad\u30a2\u30d7\u30ed\u30fc\u30c1\u306e\u4f7f\u7528\u306b\u306f\u3001\u3044\u304f\u3064\u304b\u306e\u5236\u9650\u304c\u3042\u308a\u307e\u3059\u3002\u75c5\u539f\u4f53\u306e\u540c\u5b9a\u306e\u305f\u3081\u306e\u8840\u6db2\u57f9\u990a\u306e\u4f7f\u7528\u306f\u3001\u5fae\u751f\u7269\u306e\u7a2e\u985e\u304a\u3088\u3073\u6297\u751f\u7269\u8cea\u6cbb\u7642\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u306b\u95a2\u3059\u308b\u60c5\u5831\u3092\u63d0\u4f9b\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u5206\u6790\u3055\u308c\u305f\u57f9\u990a\u306e\u3054\u304f\u4e00\u90e8\u306e\u307f\u304c\u967d\u6027\u7d50\u679c\u3092\u793a\u3057\u3001\u5168\u8eab\u611f\u67d3\u304c\u7591\u308f\u308c\u305f\u60a3\u8005\u306e\u7d0440\uff5e90%\u3067\u306f\u3001\u7d50\u679c\u306f\u5897\u6b96\u3059\u308b\u75c5\u539f\u4f53\u3092\u793a\u3055\u306a\u3044\u9670\u6027\u8840\u6db2\u57f9\u990a\u3068\u306a\u308a\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u7d50\u679c\u304c\u51fa\u308b\u307e\u3067\u306e\u6642\u9593\u304c\u9577\u3044\u3068\u521d\u671f\u6cbb\u7642\u306e\u610f\u601d\u6c7a\u5b9a\u304c\u5236\u9650\u3055\u308c\u3001\u6c5a\u67d3\u306b\u3088\u3063\u3066\u5f97\u3089\u308c\u305f\u7d50\u679c\u306e\u7279\u7570\u6027\u304c\u6700\u9069\u4ee5\u4e0b\u306b\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u8a3a\u65ad\u30ef\u30fc\u30af\u30a2\u30c3\u30d7\u3092\u6539\u5584\u3059\u308b\u305f\u3081\u306b\u3001\u8ffd\u52a0\u306e\u691c\u67fb\u306f\u6709\u7528\u3067\u3042\u308a\u3001\u65e9\u671f\u306e\u4fe1\u983c\u3067\u304d\u308b\u8a3a\u65ad\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059[3]\u3002 IL-6\u304a\u3088\u3073\u65b0\u751f\u5150\u6557\u8840\u75c7\u306b\u304a\u3051\u308b\u305d\u306e\u5f79\u5272 \u65b0\u751f\u5150\u6557\u8840\u75c7\u306f\u3001\u4e16\u754c\u4e2d\u3067\u5168\u969c\u5bb3\u8abf\u6574\u751f\u5b58\u5e74\u306e0.97%\u3092\u5360\u3081\u3001\u7d50\u8178\u30fb\u76f4\u8178\u304c\u3093\u3001\u5598\u606f\u3001\u4e73\u304c\u3093\u3088\u308a\u3082\u9ad8\u3044\u5272\u5408\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u65b0\u751f\u5150\u6557\u8840\u75c7\u306e\u6b7b\u4ea1\u7387\u306f11\uff5e19%2\u3068\u9ad8\u304f\u3001\u8133\u640d\u50b7\u3084\u5e7c\u5150\u671f\u306b\u304a\u3051\u308b\u795e\u7d4c\u767a\u9054\u30fb\u6210\u9577\u306e\u4e0d\u826f\u8ee2\u5e30\u3068\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u6709\u5bb3\u8ee2\u5e30\u3092\u9632\u3050\u306b\u306f\u3001\u65e9\u671f\u306e\u767a\u898b\u3068\u8fc5\u901f\u306a\u4ecb\u5165\u304c\u5fc5\u8981\u3067\u3059\u3002\u6557\u8840\u75c7\u306f\u611f\u67d3\u306b\u5bfe\u3059\u308b\u5168\u8eab\u6027\u708e\u75c7\u53cd\u5fdc\u3067\u3042\u308b\u305f\u3081\u3001\u8840\u6db2\u304b\u3089\u306e\u7d30\u83cc\u306e\u5358\u96e2\u304c\u30b4\u30fc\u30eb\u30c9\u30b9\u30bf\u30f3\u30c0\u30fc\u30c9\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u8d85\u4f4e\u51fa\u751f\u4f53\u91cd\u5150\uff08VLBW\u5150\u3001\u51fa\u751f\u4f53\u91cd<1500 g\uff09\u3067\u306f\u63a1\u53d6\u3067\u304d\u308b\u8840\u6db2\u91cf\u304c\u7d040.5\uff5e1 ml\u3068\u975e\u5e38\u306b\u5c11\u306a\u304f\u3001\u4f4e\u30ec\u30d9\u30eb\u83cc\u8840\u75c7\u306e\u5272\u5408\u304c\u9ad8\u304f\u3001\u8840\u6db2\u57f9\u990a\u304c\u967d\u6027\u306b\u306a\u308b\u307e\u3067\u6642\u9593\u304c\u304b\u304b\u308b\u3053\u3068\u304b\u3089\u3001\u30d7\u30ed\u30ab\u30eb\u30b7\u30c8\u30cb\u30f3\u3001\u30ea\u30dd\u591a\u7cd6\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u3001\u30d7\u30ec\u30bb\u30d7\u30b7\u30f3\u3001\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-6\u306a\u3069\u306e\u30d1\u30e9\u30e1\u30fc\u30bf\u304c\u3001\u65b0\u751f\u5150\u6557\u8840\u75c7\u306e\u8a3a\u65ad\u7cbe\u5ea6\u306b\u3064\u3044\u3066\u691c\u8a0e\u3055\u308c\u3066\u3044\u307e\u3059\u3002 IL-6\u306f\u3001\u514d\u75ab\u5fdc\u7b54\u3001\u9020\u8840\u3001\u6025\u6027\u671f\u53cd\u5fdc\u306b\u95a2\u4e0e\u3059\u308b\u591a\u6a5f\u80fd\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3067\u3059\u3002\u611f\u67d3\u306b\u5fdc\u7b54\u3057\u3066\u3001IL-6\u306fIgM\u3001IgG\u3001IgA\u7523\u751f\u304a\u3088\u3073\u30d8\u30eb\u30d1\u30fcT\u7d30\u80de\u306e\u5897\u6b96\u3092\u5897\u5f37\u3057\u3001\u5bbf\u4e3b\u9632\u5fa1\u6a5f\u69cb\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u30a8\u30f3\u30c9\u30c8\u30ad\u30b7\u30f3\u3078\u306e\u66dd\u9732\u5f8c\u3001IL-6\u6fc3\u5ea6\u306fC\u53cd\u5fdc\u6027\u30bf\u30f3\u30d1\u30af\u8cea\uff08CRP\uff09\u306a\u3069\u306e\u6025\u6027\u671f\u53cd\u5fdc\u7269\u8cea\u306b\u5148\u7acb\u3063\u3066\u4e0a\u6607\u3057\u307e\u3059\u3002IL-6\u306f\u81cd\u5e2f\u8840\u307e\u305f\u306f\u8840\u6e05\u4e2d\u3067\u6e2c\u5b9a\u3055\u308c\u3001\u8a3a\u65ad\u7cbe\u5ea6\u304c\u7570\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u81cd\u5e2f\u8840IL-6\u306f\u3001\u65e9\u671f\u767a\u75c7\u6557\u8840\u75c7\u306b\u5bfe\u3057\u306687\uff5e100%\u306e\u611f\u5ea6\u3092\u793a\u3057\u307e\u3059\u3002\u8840\u6e05IL-6\u306f\u3001\u65e9\u767a\u578b\u6557\u8840\u75c7\u306e\u8a3a\u65ad\u306b\u5bfe\u3057\u306675\uff5e85%\u306e\u611f\u5ea6\u304a\u3088\u307372.8\uff5e88%\u306e\u7279\u7570\u5ea6\u3092\u6709\u3057\u3001\u9045\u767a\u578b\u6557\u8840\u75c7\u306b\u5bfe\u3057\u306680\uff5e93.8%\u306e\u611f\u5ea6\u304a\u3088\u307380\uff5e96%\u306e\u7279\u7570\u5ea6\u3092\u793a\u3057\u3001CRP\u3092\u4e0a\u56de\u308a\u307e\u3059\u3002\u6297\u751f\u7269\u8cea\u6cbb\u7642\u4e2d\u3001\u8840\u6e05IL-6\u6fc3\u5ea6\u306f\u6025\u901f\u306b\u691c\u51fa\u4e0d\u80fd\u306a\u5024\u306b\u4f4e\u4e0b\u3057\u307e\u3059\u3002IL-6\u306e\u9ad8\u3044\u611f\u5ea6\u304a\u3088\u3073\u9670\u6027\u7684\u4e2d\u7387\u306f\u3001\u9ad8\u7279\u7570\u5ea6\u306eCRP\u3068\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001\u65b0\u751f\u5150\u6557\u8840\u75c7\u3092\u8a3a\u65ad\u3059\u308b\u305f\u3081\u306e\u6709\u671b\u306a\u5019\u88dc\u3068\u306a\u308a\u307e\u3059\u3002 \u56f31\uff1a\u6557\u8840\u75c7\u306b\u304a\u3051\u308b\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3\u20136\u304a\u3088\u3073C\u53cd\u5fdc\u6027\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u305d\u306e\u7d4c\u6642\u7684\u5909\u53161\u65e5\u76ee\uff08a\uff09\u304a\u3088\u30737\u65e5\u76ee\u4ee5\u964d\uff08b\uff09\u306e\u57f9\u990a\u78ba\u8a8d\u6557\u8840\u75c7\u306b\u304a\u3051\u308b\u8840\u6e05\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3\u20136\u304a\u3088\u3073C\u53cd\u5fdc\u6027\u30bf\u30f3\u30d1\u30af\u8cea\uff08CRP\uff09\u3002 \u56f31\u306b\u793a\u3059\u3088\u3046\u306b\u3001\u8840\u6e05IL-6\u306f\u51fa\u751f1\u65e5\u76ee\uff08DOL1\uff09\u306e\u57f9\u990a\u78ba\u8a8d\u6557\u8840\u75c7\u3067\u975e\u5e38\u306b\u65e9\u671f\u304b\u3089\u4e0a\u6607\u3057\u307e\u3059\u304c\u3001CRP\u304c\u30d4\u30fc\u30af\u306b\u9054\u3059\u308b\u306b\u306f\u7d0448\u6642\u9593\u3092\u8981\u3057\u307e\u3059\u3002\u8840\u6e05IL-6\u306e\u9ad8\u3044\u7cbe\u5ea6\u306b\u57fa\u3065\u304d\u3001DOL1\u3067\u6e2c\u5b9a\u3055\u308c\u305fIL-6\u306f\u5148\u5929\u6027\u6557\u8840\u75c7\u306e\u8a3a\u65ad\u306b\u6975\u3081\u3066\u6709\u7528\u3067\u3042\u308b\u3068\u7d50\u8ad6\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u56f31\u306b\u793a\u3059\u3088\u3046\u306b\u3001\u8840\u6e05IL-6\u306f\u3001DOL7\u4ee5\u964d\u306e\u57f9\u990a\u78ba\u8a8d\u6557\u8840\u75c7\u306e\u30a8\u30d4\u30bd\u30fc\u30c9\u306b\u304a\u3044\u3066\u3001CRP\u3088\u308a24\uff5e48\u6642\u9593\u65e9\u304f\u4e0a\u6607\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u8840\u6e05IL-6\u306f\u3001\u751f\u5f8c1\u9031\u9593\u4ee5\u964d\u306b\u767a\u75c7\u3059\u308b\u6557\u8840\u75c7\u75c7\u4f8b\u3067\u6700\u3082\u65e9\u671f\u306b\u4e0a\u6607\u3059\u308b\u6700\u3082\u6b63\u78ba\u306a\u691c\u67fb\u5ba4\u30d1\u30e9\u30e1\u30fc\u30bf\u3068\u306a\u308a\u307e\u3059\u3002Tzialla\u3089\u306f\u3001\u6025\u6027\u671f\u53cd\u5fdc\u7269\u8cea\u306b\u5148\u7acb\u3063\u3066\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u30ec\u30d9\u30eb\u304c\u6025\u901f\u306b\u5909\u5316\u3059\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u307e\u3057\u305f\u3002 \u8840\u6e05IL-6\u306e\u7cbe\u5ea6\u306f\u9ad8\u304f\u3001\u3068\u308a\u308f\u3051\u9670\u6027\u7684\u4e2d\u7387\u304c\u975e\u5e38\u306b\u9ad8\u3044\u3053\u3068\u304b\u3089\u3001\u8840\u6e05IL-6\u306f\u65b0\u751f\u5150\u3084\u65e9\u7523\u5150\u306e\u6557\u8840\u75c7\u8a3a\u65ad\u306b\u6709\u7528\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u3055\u3089\u306b\u3001IL-6\u306f\u52b9\u679c\u7684\u306a\u6297\u751f\u7269\u8cea\u6cbb\u7642\u958b\u59cb\u5f8c\u306b\u6025\u901f\u306b\u4f4e\u4e0b\u3057\u3001\u6297\u751f\u7269\u8cea\u6cbb\u7642\u306e\u8fc5\u901f\u306a\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u3084\u3001\u6cbb\u7642\u306e\u9069\u6642\u306a\u6f38\u5897\u30fb\u6f38\u6e1b\u3092\u53ef\u80fd\u306b\u3057\u307e\u3059[4]\u3002 \u7d50\u8ad6 \u6557\u8840\u75c7\u306f\u751f\u547d\u3092\u8105\u304b\u3059\u75be\u60a3\u3067\u3042\u308a\u3001ICU\u5165\u9662\u60a3\u8005\u306e\u6700\u3082\u4e00\u822c\u7684\u306a\u539f\u56e0\u306e1\u3064\u3067\u3059\u3002\u6557\u8840\u75c7\u306e\u6b7b\u4ea1\u7387\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u306b\u306f\u3001\u65e9\u671f\u8a3a\u65ad\u304a\u3088\u3073\u9069\u5207\u306a\u7ba1\u7406\u304c\u5fc5\u8981\u3067\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u611f\u67d3\u75c7\u306b\u5bfe\u3059\u308b\u751f\u7406\u53cd\u5fdc\u306f\u500b\u4f53\u5dee\u304c\u5927\u304d\u304f\u3001\u307e\u305f\u6557\u8840\u75c7\u306e\u5fb4\u5019\u3084\u75c7\u72b6\u3082\u975e\u7279\u7570\u7684\u3067\u3042\u308b\u305f\u3081\u3001\u65e9\u671f\u8a3a\u65ad\u306f\u56f0\u96e3\u3067\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u6557\u8840\u75c7\u306e\u8a3a\u65ad\u306e\u305f\u3081\u306e\u591a\u304f\u306e\u6f5c\u5728\u7684\u306a\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u304c\u8abf\u67fb\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u5206\u5b50\u306f\u4e3b\u306b\u611f\u67d3\u306b\u5bfe\u3059\u308b\u81ea\u7136\u514d\u75ab\u5fdc\u7b54\u306e\u521d\u671f\u75c5\u614b\u5f62\u6210\u306b\u95a2\u4e0e\u3057\u3001\u591a\u304f\u306e\u5834\u5408\u3001\u4e88\u5f8c\u7684\u4fa1\u5024\u4e26\u3073\u306b\u8a3a\u65ad\u7684\u4fa1\u5024\u3092\u793a\u3057\u307e\u3059\u3002\u6557\u8840\u75c7\u306e\u4e88\u5f8c\u30de\u30fc\u30ab\u30fc\u306f\u3001\u6557\u8840\u75c7\u306b\u3088\u308b\u81d3\u5668\u6a5f\u80fd\u4e0d\u5168\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u591a\u304f\u3001\u3053\u308c\u3089\u306e\u4e88\u5f8c\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3092\u6a19\u7684\u3068\u3059\u308b\u6557\u8840\u75c7\u6cbb\u7642\u85ac\u306e\u958b\u767a\u304c\u8a66\u307f\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u6280\u8853\u306e\u6700\u8fd1\u306e\u9032\u6b69\u306f\u3001\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\u304a\u3088\u3073\u975e\u30b3\u30fc\u30c9RNA\u306a\u3069\u306e\u65b0\u3057\u3044\u30bf\u30a4\u30d7\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u958b\u767a\u3092\u3082\u305f\u3089\u3057\u307e\u3057\u305f\u3002\u8178\u5185\u5fae\u751f\u7269\u53e2\u306f\u3001\u514d\u75ab\u7cfb\u306e\u767a\u9054\u3068\u6210\u719f\u3001\u304a\u3088\u3073\u75c5\u539f\u4f53\u306b\u5bfe\u3059\u308b\u4fdd\u8b77\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u8178\u5185\u6bd2\u7d20\u75c7\u306f\u3001\u6557\u8840\u75c7\u306e\u767a\u75c7\u304a\u3088\u3073\u9032\u884c\u306b\u95a2\u3059\u308b\u5f37\u529b\u306a\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002miRNA\u3092\u542b\u3080\u975e\u30b3\u30fc\u30c9RNA\u304a\u3088\u3073\u9577\u3044\u975e\u30b3\u30fc\u30c9RNA\u306f\u3001\u69d8\u3005\u306a\u65b9\u6cd5\u3067\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u8abf\u7bc0\u3057\u307e\u3059\u304c\u3001\u6557\u8840\u75c7\u306e\u75c5\u56e0\u306b\u304a\u3051\u308b\u305d\u308c\u3089\u306e\u6a5f\u80fd\u304a\u3088\u3073\u6a5f\u69cb\u306f\u5b8c\u5168\u306b\u306f\u7406\u89e3\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002 \u6557\u8840\u75c7\u306e\u767a\u75c7\u6a5f\u5e8f\u306b\u304a\u3051\u308b\u3053\u308c\u3089\u306e\u65b0\u3057\u3044\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u5f79\u5272\u3001\u4e26\u3073\u306b\u3053\u308c\u3089\u306e\u65b0\u3057\u3044\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3092\u5206\u6790\u3059\u308b\u305f\u3081\u306e\u6700\u9069\u306a\u6b63\u898f\u5316\u6226\u7565\u306e\u958b\u767a\u306b\u95a2\u3059\u308b\u66f4\u306a\u308b\u8a55\u4fa1\u304c\u3001\u305d\u308c\u3089\u306e\u5c06\u6765\u306e\u81e8\u5e8a\u4f7f\u7528\u306e\u305f\u3081\u306b\u5fc5\u8981\u3068\u3055\u308c\u308b\u3067\u3057\u3087\u3046[5]\u3002 \u53c2\u8003\u6587\u732e\uff1a [1]Sepsis Clinical Care Standard 2022 [2] Global Burden of Disease study [3]\u00a0Gregoriano, C.et al. (2020) \u2018Role of procalcitonin use in the management of sepsis\u2019, […]<\/p>\n","protected":false},"author":1,"featured_media":85901,"parent":0,"menu_order":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"tags":[13336,13419],"pillarandcategory":[295,282,317,309],"reporter":[13340],"class_list":["post-142779","acf_article","type-acf_article","status-publish","has-post-thumbnail","hentry","tag-13336","tag-13419","pillarandcategory-sepsis","pillarandcategory-disease-area","pillarandcategory-immunoassay","pillarandcategory-operations","reporter-niti-dawar"],"acf":[],"_links":{"self":[{"href":"https:\/\/labinsights.com\/ja\/wp-json\/wp\/v2\/acf_article\/142779","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labinsights.com\/ja\/wp-json\/wp\/v2\/acf_article"}],"about":[{"href":"https:\/\/labinsights.com\/ja\/wp-json\/wp\/v2\/types\/acf_article"}],"author":[{"embeddable":true,"href":"https:\/\/labinsights.com\/ja\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":3,"href":"https:\/\/labinsights.com\/ja\/wp-json\/wp\/v2\/acf_article\/142779\/revisions"}],"predecessor-version":[{"id":148712,"href":"https:\/\/labinsights.com\/ja\/wp-json\/wp\/v2\/acf_article\/142779\/revisions\/148712"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/labinsights.com\/ja\/wp-json\/wp\/v2\/media\/85901"}],"wp:attachment":[{"href":"https:\/\/labinsights.com\/ja\/wp-json\/wp\/v2\/media?parent=142779"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/labinsights.com\/ja\/wp-json\/wp\/v2\/tags?post=142779"},{"taxonomy":"pillarandcategory","embeddable":true,"href":"https:\/\/labinsights.com\/ja\/wp-json\/wp\/v2\/pillarandcategory?post=142779"},{"taxonomy":"reporter","embeddable":true,"href":"https:\/\/labinsights.com\/ja\/wp-json\/wp\/v2\/reporter?post=142779"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}