{"id":142794,"date":"2023-12-04T06:30:13","date_gmt":"2023-12-04T06:30:13","guid":{"rendered":"https:\/\/labinsights.com\/acf_article\/%e5%bf%83%e4%b8%8d%e5%85%a8%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e5%87%9d%e5%9b%ba%e9%9a%9c%e5%ae%b3%ef%bc%9a%e7%97%85%e6%85%8b%e7%94%9f%e7%90%86%e3%81%a8%e8%87%a8%e5%ba%8a%e7%ae%a1%e7%90%86\/"},"modified":"2026-02-19T09:33:42","modified_gmt":"2026-02-19T09:33:42","slug":"coagulation-disorders-in-heart-failure-pathophysiology-and-clinical-management","status":"publish","type":"acf_article","link":"https:\/\/labinsights.com\/ja\/disease-area\/cardiology\/coagulation-disorders-in-heart-failure-pathophysiology-and-clinical-management\/","title":{"rendered":"\u5fc3\u4e0d\u5168\u306b\u304a\u3051\u308b\u51dd\u56fa\u969c\u5bb3\uff1a\u75c5\u614b\u751f\u7406\u3068\u81e8\u5e8a\u7ba1\u7406"},"content":{"rendered":"

\u5fc3\u4e0d\u5168\u306b\u304a\u3051\u308b\u8840\u6db2\u51dd\u56fa\u969c\u5bb3<\/h2>\n

\u5fc3\u4e0d\u5168\uff08HF\uff09\u306f\u3001\u5fc3\u81d3\u306e\u69cb\u9020\u7684\u307e\u305f\u306f\u6a5f\u80fd\u7684\u969c\u5bb3\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u81e8\u5e8a\u75c7\u5019\u7fa4\u3067\u3042\u308a\u3001\u5fc3\u5185\u5727\u306e\u4e0a\u6607\u304a\u3088\u3073\/\u307e\u305f\u306f\u904b\u52d5\u3082\u3057\u304f\u306f\u5b89\u9759\u6642\u306e\u4e0d\u5341\u5206\u306a\u5fc3\u62cd\u51fa\u91cf\u3092\u3082\u305f\u3089\u3057\u307e\u3059\u3002\u672c\u75be\u60a3\u306f\u3001\u52d5\u8108\u304a\u3088\u3073\u9759\u8108\u306e\u8840\u6813\u6027\u4e8b\u8c61\u306e\u4e21\u65b9\u306e\u30ea\u30b9\u30af\u5897\u52a0\u3068\u95a2\u9023\u3057\u307e\u3059\u3002\u81e8\u5e8a\u533b\u304c\u3053\u306e\u554f\u984c\u306b\u6c17\u3065\u304d\u3001\u7814\u7a76\u3092\u6df1\u3081\u3001\u7ba1\u7406\u3059\u308b\u305f\u3081\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3092\u660e\u78ba\u306b\u3059\u308b\u3053\u3068\u3067\u3001HF\u60a3\u8005\u306e\u51dd\u56fa\u969c\u5bb3\u306e\u8a3a\u65ad\u3068\u6cbb\u7642\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n

HF\u306b\u304a\u3051\u308b\u51dd\u56fa\u969c\u5bb3\u306e\u75c5\u614b\u751f\u7406<\/h2>\n

HF\u306f\u5de6\u5ba4\u99c6\u51fa\u7387\u306b\u57fa\u3065\u3044\u30663\u3064\u306e\u30b5\u30d6\u30bf\u30a4\u30d7\u306b\u5206\u985e\uff1a\u99c6\u51fa\u7387\u304c\u4f4e\u4e0b\u3057\u305fHF\uff08HFrEF\uff09\uff1a\u99c6\u51fa\u7387\u304c\u8efd\u5ea6\u4f4e\u4e0b\u3057\u305fHF\uff08HFmrEF\uff09\uff1b\u99c6\u51fa\u7387\u304c\u4fdd\u6301\u3055\u308c\u305fHF\uff08HFpEF\uff09\u3002\u5404\u30b5\u30d6\u30bf\u30a4\u30d7\u306b\u306f\u7279\u7570\u7684\u306a\u81e8\u5e8a\u7684\u7279\u5fb4\u3068\u3001\u8840\u6813\u585e\u6813\u6027\u5408\u4f75\u75c7\u306e\u591a\u69d8\u306a\u30ea\u30b9\u30af\u3092\u542b\u3080\u3001\u4e00\u822c\u7684\u306a\u5408\u4f75\u75c7\u304c\u8a8d\u3081\u3089\u308c\u307e\u3059[2]\u3002<\/p>\n

\"coagulation_disorders_in_heart_failure\"<\/p>\n

HF\u3068\u8840\u6813\u75c7\u306f\u3001\u3057\u3070\u3057\u3070\u8907\u6570\u306e\u7406\u7531\u3067\u95a2\u9023\u3057\u307e\u3059\u3002\u624b\u59cb\u3081\u306b\u3001\u5fc3\u4e0d\u5168\u306e\u4e3b\u306a\u539f\u56e0\u3067\u3042\u308b\u865a\u8840\u6027\u5fc3\u75be\u60a3\u306f\u3001\u8840\u5c0f\u677f\u306e\u6d3b\u6027\u5316\u3068\u51dd\u96c6\u3092\u4ecb\u3059\u308b\u52d5\u8108\u8840\u6813\u306e\u5f62\u6210\u306e\u7d20\u56e0\u3067\u3042\u308a\u307e\u3059\u3002\u9759\u8108\u8840\u6813\u585e\u6813\u75c7\uff08VTE\uff09\u3082\u5fc3\u4e0d\u5168\u3067\u3088\u304f\u307f\u3089\u308c\u3001\u5fc3\u585e\u6813\u6027\u8133\u5352\u4e2d\u304a\u3088\u3073\u7a81\u7136\u6b7b\u306e\u30ea\u30b9\u30af\u4e0a\u6607\u306e\u4e00\u56e0\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u8840\u6813\u585e\u6813\u75c7\u3068\u8133\u5352\u4e2d\u306e\u30ea\u30b9\u30af\u306f\u3001HF\u60a3\u8005\u306b\u5fc3\u623f\u7d30\u52d5\uff08AF\uff09\u306a\u3069\u4ed6\u306e\u4f75\u5b58\u75be\u60a3\u304c\u3042\u308b\u5834\u5408\u306b\u7279\u306b\u9ad8\u304f\u306a\u308a\u307e\u3059\u3002\u65b0\u305f\u306bHF\u3068\u8a3a\u65ad\u3055\u308c\u305f\u60a3\u8005\u306e\u534a\u6570\u4ee5\u4e0a\u3067\u5fc3\u623f\u7d30\u52d5\u304c\u8a8d\u3081\u3089\u308c\u3001\u5fc3\u623f\u7d30\u52d5\u3068\u5fc3\u4e0d\u5168\u306e\u4e21\u65b9\u304c\u8a8d\u3081\u3089\u308c\u308b\u3068\u3001\u6b7b\u4ea1\u30ea\u30b9\u30af\u304c\u3088\u308a\u9ad8\u304f\u306a\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

\"coagulation_disorders_in_heart_failure\"<\/p>\n

Virchow\u306e3\u4e3b\u5fb4\u3067\u3042\u308b\u5185\u76ae\u6a5f\u80fd\u969c\u5bb3\u3001\u8840\u6d41\u306e\u505c\u6ede\u3001\u304a\u3088\u3073\u51dd\u56fa\u4ea2\u9032\u306e3\u3064\u306e\u69cb\u6210\u8981\u7d20\u306e\u5168\u3066\u306b\u7570\u5e38\u304c\u3042\u308b\u3068\u3001HF\u306b\u304a\u3051\u308b\u8840\u6813\u75c7\u306b\u5bfe\u3059\u308b\u8106\u5f31\u6027\u304c\u9ad8\u307e\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u52d5\u8108\u304a\u3088\u3073\u9759\u8108\u8840\u6813\u75c7\u306e\u75c5\u56e0\u306f\u7570\u306a\u308a\u307e\u3059\u3002\u52d5\u8108\u8840\u6813\u306f\u8840\u5c0f\u677f\u306b\u5bcc\u307f\u3001\u9ad8\u3044\u526a\u65ad\u5fdc\u529b\u4e0b\u3067\u5f62\u6210\u3055\u308c\u308b\u306e\u306b\u5bfe\u3057\u3066\u3001\u9759\u8108\u8840\u6813\u306f\u30d5\u30a3\u30d6\u30ea\u30f3\u306b\u5bcc\u307f\u3001\u3088\u308a\u4f4e\u3044\u526a\u65ad\u5fdc\u529b\u74b0\u5883\u4e0b\u3067\u5f62\u6210\u3055\u308c\u307e\u3059\u3002HF\u306e\u75c5\u56e0\u3084\u4f75\u5b58\u75c7\u306b\u304b\u304b\u308f\u3089\u305a\u3001\u8840\u5c0f\u677f\u6a5f\u80fd\u306e\u7834\u7dbb\u3084HF\u3067\u307f\u3089\u308c\u308b\u51dd\u56fa\u30ab\u30b9\u30b1\u30fc\u30c9\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u3063\u3066\u3001\u8840\u6813\u5f62\u6210\u304c\u4fc3\u9032\u3055\u308c\u307e\u3059[2]\u3002<\/p>\n

\u8840\u6813\u585e\u6813\u6027\u306e\u5408\u4f75\u75c7\u306f\u3001\u5178\u578b\u7684\u306b\u306fHF\u60a3\u8005\u306e\u4e3b\u305f\u308b\u554f\u984c\u3068\u306f\u307f\u306a\u3055\u308c\u306a\u3044\u304c\u3001\u304b\u306a\u308a\u306e\u51dd\u56fa\u969c\u5bb3\u3092\u4f34\u3044\u307e\u3059[3]\u3002\u4f8b\u3048\u3070\u3001\u8133\u5352\u4e2d\u306e\u767a\u75c7\u7387\u306f\u3001\u5fc3\u4e0d\u5168\u306b\u3088\u308b\u8a3a\u65ad\u53c8\u306f\u4ee3\u511f\u4e0d\u5168\u304b\u30891\u30ab\u6708\u4ee5\u5185\u306b\u9ad8\u304f\u306a\u308a\u3001\u6025\u6027\u4e8b\u8c61\u5f8c6\u304b\u6708\u4ee5\u5185\u306b\u4f4e\u4e0b\u3057\u307e\u3059[4]\u3002HF\u60a3\u8005\u306b\u304a\u3051\u308b\u8840\u6813\u5f62\u6210\u4fc3\u9032\u8868\u73fe\u578b\u306f\u3001(1)\u6162\u6027\u4f4e\u9178\u7d20\u75c7\u306b\u3088\u308a\u8a98\u5c0e\u3055\u308c\u308b\u5168\u8eab\u6027\u708e\u75c7\u53cd\u5fdc\u3001(2)\u8840\u6813\u5f62\u6210\u4fc3\u9032\u6027\u5206\u5b50\u306e\u6fc3\u5ea6\u4e0a\u6607\u3001\u307e\u305f\u306f(3)\u52d5\u8108\u304a\u3088\u3073\u9759\u8108\u5185\u76ae\u6a5f\u80fd\u969c\u5bb3\u306b\u8d77\u56e0\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

\"coagulation_disorders_in_heart_failure\"<\/p>\n

HF\u306f\u307e\u305f\u3001\u969c\u5bb3\u306e\u60aa\u5316\u3001\u518d\u5165\u9662\u306e\u5897\u52a0\u3001\u8133\u5352\u4e2d\u5f8c\u306e\u6b7b\u4ea1\u7387\u306e\u4e0a\u6607\u306e\u72ec\u7acb\u3057\u305f\u5371\u967a\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u3082\u5224\u660e\u3057\u307e\u3057\u305f\u3002\u305d\u308c\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001HF\u306b\u304a\u3051\u308b\u51dd\u56fa\u7570\u5e38\u306b\u95a2\u9023\u3059\u308b\u5408\u4f75\u75c7\u304a\u3088\u3073\u6b7b\u4ea1\u306e\u6e1b\u5c11\u306b\u304a\u3051\u308b\u6297\u51dd\u56fa\u7642\u6cd5\u304a\u3088\u3073\u6297\u8840\u5c0f\u677f\u7642\u6cd5\u306e\u5f79\u5272\u306b\u95a2\u3059\u308b\u660e\u78ba\u306a\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306f\u3042\u308a\u307e\u3059[1]\u3002\u3057\u305f\u304c\u3063\u3066\u3001HF\u306f\u8840\u6813\u5f62\u6210\u4fc3\u9032\u72b6\u614b\u3092\u7279\u5fb4\u3068\u3057\u3001\u305d\u306e\u7f79\u60a3\u7387\u3068\u6b7b\u4ea1\u7387\u3092\u60aa\u5316\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001HF\u306b\u304a\u3051\u308b\u8840\u6813\u585e\u6813\u6027\u5408\u4f75\u75c7\u306e\u30ea\u30b9\u30af\u306e\u5897\u52a0\u306f\u3001\u904e\u5c0f\u8a55\u4fa1\u3055\u308c\u3066\u3044\u308b\u81e8\u5e8a\u7684\u8ab2\u984c\u3067\u3059\u3002<\/p>\n

HF\u306b\u304a\u3051\u308b\u51dd\u56fa\u969c\u5bb3\u306e\u81e8\u5e8a\u7ba1\u7406<\/h2>\n

HF\u60a3\u8005\u3067\u306f\u3001\u6d3b\u6027\u5316\u51dd\u56fa\u304a\u3088\u3073\/\u307e\u305f\u306f\u8840\u5c0f\u677f\u6d3b\u6027\u5316\u306e\u30de\u30fc\u30ab\u30fc\u304c\u3001\u5185\u76ae\u6a5f\u80fd\u969c\u5bb3\u304a\u3088\u3073\u5fc3\u62cd\u51fa\u91cf\u4f4e\u4e0b\u3001\u7570\u5e38\u306a\u8840\u6d41\u53ca\u3073\u505c\u6ede\u306b\u95a2\u9023\u3059\u308b\u72b6\u614b\u3068\u5171\u306b\u89b3\u5bdf\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u3044\u304f\u3064\u304b\u306e\u4e00\u822c\u7684\u306b\u8a8d\u3081\u3089\u308c\u308b\u4f75\u5b58\u75c7\u304c\u3057\u3070\u3057\u3070HF\u3092\u5408\u4f75\u3057\u3001\u8840\u6813\u585e\u6813\u75c7\u306e\u30ea\u30b9\u30af\u3092\u3055\u3089\u306b\u9ad8\u3081\u307e\u3059\u3002<\/p>\n

\u6025\u6027HF\u306e\u5165\u9662\u60a3\u8005\u3067\u7981\u5fcc\u304c\u306a\u3044\u5834\u5408\u3001\u304a\u3088\u3073\u9577\u671f\u306e\u6a5f\u68b0\u7684\u5faa\u74b0\u88dc\u52a9\u3092\u53d7\u3051\u3066\u3044\u308b\u5834\u5408\u3001\u4f4e\u5206\u5b50\u91cf\u30d8\u30d1\u30ea\u30f3\u306b\u3088\u308b\u8840\u6813\u585e\u6813\u75c7\u306e\u4e88\u9632\u304c\u63a8\u5968\u3055\u308c\u307e\u3059[1]\u3002\u904e\u53bb10\u5e74\u9593\u3067\u3001\u76f4\u63a5\u578b\u7d4c\u53e3\u6297\u51dd\u56fa\u85ac\uff08DOAC\uff09\u306f\u3001\u975e\u5f01\u819c\u75c7\u6027\u5fc3\u623f\u7d30\u52d5\u306b\u304a\u3051\u308b\u8133\u5352\u4e2d\u304a\u3088\u3073\u5168\u8eab\u6027\u585e\u6813\u75c7\uff08SSE\uff09\u306e\u6cbb\u7642\u304a\u3088\u3073\u4e88\u9632\u306b\u3082\u627f\u8a8d\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u85ac\u5264\u306f\u3001\u51fa\u8840\u30ea\u30b9\u30af\u304c\u3088\u308a\u4f4e\u3044\u30ef\u30eb\u30d5\u30a1\u30ea\u30f3\u306e\u4ee3\u66ff\u85ac\u3067\u3059[3]\u3002<\/p>\n

\u5fc3\u623f\u7d30\u52d5\u304a\u3088\u3073\u5fc3\u4e0d\u5168\u3092\u6709\u3059\u308b\u60a3\u8005\u306b\u304a\u3051\u308b\u6297\u51dd\u56fa\u7642\u6cd5\u306f\u3001\u3053\u308c\u3089\u306e\u60a3\u8005\u306e\u8840\u6813\u585e\u6813\u75c7\u306e\u9ad8\u3044\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b\u305f\u3081\u306b\u5e83\u304f\u4e0d\u53ef\u6b20\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002ESC\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u306f\u3001\u5fc3\u623f\u7d30\u52d5\u306b\u304a\u3051\u308b\u8133\u5352\u4e2d\u306e\u4e88\u9632\u306b\u30ef\u30eb\u30d5\u30a1\u30ea\u30f3\u3088\u308a\u3082DOAC\u3092\u63a8\u5968\u3057\u3066\u3044\u308b\u304c\u3001\u3053\u308c\u306f\u3001\u3053\u308c\u3089\u306e\u85ac\u5264\u304c\u3088\u308a\u5b89\u5168\u306a\u81e8\u5e8a\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3067\u540c\u69d8\u306b\u52b9\u679c\u7684\u3067\u3042\u308b\u305f\u3081\u3067\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001HF\u60a3\u8005\u306f\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u3067\u306f\u5341\u5206\u306b\u8a55\u4fa1\u3055\u308c\u3066\u3044\u307e\u305b\u3093[3]\u3002<\/p>\n

\u5fc3\u623f\u7d30\u52d5\u306e\u3042\u308bHF\u60a3\u8005\u3067\u306f\u3001\u30a2\u30d4\u30ad\u30b5\u30d0\u30f3\u304a\u3088\u3073\u30c0\u30d3\u30ac\u30c8\u30e9\u30f3\u306e\u3088\u3046\u306aDOAC\uff08\u30ea\u30d0\u30fc\u30ed\u30ad\u30b5\u30d0\u30f3\u3067\u306f\u306a\u3044\uff09\u306f\u3001\u5168\u3066\u306e\u814e\u6a5f\u80fd\u30ec\u30d9\u30eb\u306b\u304a\u3044\u3066\u3001\u30ef\u30eb\u30d5\u30a1\u30ea\u30f3\u3088\u308a\u3082\u7dcf\u51fa\u8840\u304a\u3088\u3073\u6b7b\u4ea1\u306e\u30ea\u30b9\u30af\u304c\u4f4e\u304f\u306a\u3063\u3066\u3044\u307e\u3059\u3002DOAC\u306b\u3088\u308b\u6cbb\u7642\u306f\u30ef\u30eb\u30d5\u30a1\u30ea\u30f3\u3088\u308a\u3082\u304b\u306a\u308a\u8907\u96d1\u3068\u3044\u3046\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u5fc3\u4e0d\u5168\u60a3\u8005\u306b\u304a\u3051\u308b\u4f7f\u7528\u306f\u5bb9\u6613\u306b\u5fd8\u308c\u3089\u308c\u308b\u554f\u984c\u3067\u3082\u3042\u308a\u307e\u305b\u3093\u3002\u814e\u6a5f\u80fd\u306fHF\u60a3\u8005\u3067\u306f\u4e00\u822c\u7684\u306b\u5909\u52d5\u3057\u3001\u3068\u304d\u306bDOAC\u306e\u7528\u91cf\u8abf\u6574\u304c\u5fc5\u8981\u3068\u306a\u308b\u304c\u3001\u5b9f\u969b\u306b\u306f\u3053\u308c\u3089\u306e\u8abf\u6574\u306f\u307e\u308c\u3067\u3057\u305f\u3002\u814e\u6a5f\u80fd\u306e\u308f\u305a\u304b\u306a\u4f4e\u4e0b\u3067\u3042\u3063\u3066\u3082\u3001DOAC\u6cbb\u7642\u60a3\u8005\u306b\u304a\u3051\u308b\u51fa\u8840\u30ea\u30b9\u30af\u306e\u5897\u52a0\u306b\u95a2\u9023\u3057\u3001\u6ce8\u610f\u6df1\u3044\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u306e\u5fc5\u8981\u6027\u3092\u5f37\u8abf\u3057\u3001\u7528\u91cf\u3092\u9069\u5207\u306b\u8abf\u6574\u3057\u307e\u3057\u305f\u3002<\/p>\n

\"coagulation_disorders_in_heart_failure\"<\/p>\n

\u6297\u51dd\u56fa\u85ac\u306e\u8a3a\u7642\u6240\u307e\u305f\u306f\u81e8\u5e8a\u85ac\u5264\u5e2b\u306b\u3088\u308b\u30b9\u30da\u30b7\u30e3\u30ea\u30b9\u30c8\u30b1\u30a2\u306f\u3001DOAC\u306e\u7528\u91cf\u8abf\u7bc0\u304a\u3088\u3073\u8ee2\u5e30\u306e\u6539\u5584\u3068\u95a2\u9023\u3057\u307e\u3059\u3002\u90e8\u4f4d\u9593\u306e\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u306e\u89b3\u5bdf\u3055\u308c\u305f\u5909\u52d5\u306e\u3055\u3089\u306a\u308b\u7814\u7a76\u306f\u3001DOAC\u51e6\u7f6e\u60a3\u8005\u306e\u30b1\u30a2\u306e\u8cea\u3092\u3055\u3089\u306b\u6539\u5584\u3059\u308b\u6a5f\u4f1a\u3092\u63d0\u4f9b\u3057\u5f97\u307e\u3059[4]\u3002<\/p>\n

\u3055\u3089\u306a\u308b\u7814\u7a76\u306e\u5fc5\u8981\u6027<\/h2>\n

\u4e16\u754c\u7684\u306a\u6709\u75c5\u7387\u306f1%\u301c2%\u3067\u3042\u308a\u3001HF\u306f800\u4e07\u4eba\u3092\u8d85\u3048\u308b\u6210\u4eba\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3068\u4e88\u6e2c\u3055\u308c\u3066\u3044\u308b\u91cd\u5927\u306a\u4e16\u754c\u7684\u75be\u60a3\u3067\u3042\u308a\u3001HF\u306b\u95a2\u9023\u3059\u308b\u7dcf\u30b3\u30b9\u30c8\u306f2030\u5e74\u307e\u3067\u306b700\u5104\u30c9\u30eb\u306b\u5897\u52a0\u3059\u308b\u3068\u63a8\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002 \u690d\u8fbc\u307f\u578b\u9664\u7d30\u52d5\u5668\u306e\u5c0e\u5165\u3084\u5fc3\u81d3\u518d\u540c\u671f\u7642\u6cd5\u306a\u3069\u3001\u5fc3\u4e0d\u5168\u306e\u5185\u79d1\u7684\u7ba1\u7406\u306b\u304a\u3051\u308b\u6700\u8fd1\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u304f\u9032\u6b69\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u5fc3\u4e0d\u5168\u306b\u95a2\u9023\u3059\u308b\u6b7b\u4ea1\u7387\u306f5\u5e74\u6642\u70b9\u3067\u7d0450%\u3068\u4f9d\u7136\u3068\u3057\u3066\u9ad8\u304f\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n

HF\u60a3\u8005\u306f\u8840\u6813\u585e\u6813\u75c7\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u3001\u7279\u306b\u5fc3\u623f\u7d30\u52d5\u306e\u5b58\u5728\u4e0b\u3067\u306f\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3053\u3068\u3092\u8003\u616e\u3059\u308b\u3068\u3001DOAC\u6cbb\u7642\u306f\u5b89\u5168\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u304c\u826f\u597d\u306a\u8840\u6813\u585e\u6813\u6027\u4e8b\u8c61\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b\u5408\u7406\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u7279\u5b9a\u306e\u30c7\u30fc\u30bf\u304c\u4e0d\u8db3\u3057\u3066\u3044\u308b\u305f\u3081\u3001\u81e8\u5e8a\u7684\u6c7a\u5b9a\u306f\u73fe\u5728\u3001\u4e00\u822c\u7684\u306aAF\u96c6\u56e3\u306b\u304a\u3051\u308b\u5927\u304d\u306aRCT\u306e\u8a3c\u62e0\u304b\u3089\u9069\u5408\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u5fc3\u4e0d\u5168\u306b\u304a\u3051\u308bDOAC\u4f7f\u7528\u306b\u95a2\u3059\u308b\u3044\u304f\u3064\u304b\u306e\u91cd\u8981\u306a\u7591\u554f\u306f\u4f9d\u7136\u3068\u3057\u3066\u89e3\u6c7a\u3055\u308c\u3066\u304a\u3089\u305a\u3001\u3055\u3089\u306a\u308b\u8a73\u7d30\u306a\u5206\u6790\u304c\u5fc5\u8981\u3067\u3059\u3002DOAC\u306f\u3001HF\u306e\u60aa\u5316\u3084\u5165\u9662\u306a\u3069\u7279\u5b9a\u306eHF\u8a55\u4fa1\u9805\u76ee\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3057\u307e\u3059\u304b\uff1f\u4f75\u5b58\u75c7\u3092\u6709\u3059\u308bHF-AF\u60a3\u8005\u306e\u6297\u51dd\u56fa\u7642\u6cd5\u3092\u3069\u306e\u3088\u3046\u306b\u7ba1\u7406\u3059\u3079\u304d\u3067\u3059\u304b\uff1fHF-AF-CAD\u60a3\u8005\u306b\u304a\u3044\u3066\u6297\u8840\u5c0f\u677f\u85ac\u3068\u6297\u51dd\u56fa\u85ac\u3092\u3069\u306e\u3088\u3046\u306b\u7d44\u307f\u5408\u308f\u305b\u308b\u3079\u304d\u3067\u3059\u304b\uff1f\u5de6\u5ba4\u8840\u6813\u75c7\u306eHF-AF\u60a3\u8005\u306b\u304a\u3044\u3066DOAC\u3092\u5b89\u5168\u304b\u3064\u52b9\u679c\u7684\u306b\u4f7f\u7528\u3067\u304d\u307e\u3059\u304b\uff1f\u5de6\u5ba4\u8840\u6813\u75c7\u304a\u3088\u3073\u5fc3\u623f\u7d30\u52d5\u306e\u4e21\u65b9\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044HF\u60a3\u8005\u306b\u5bfe\u3057\u3066\u3001DOAC\u7642\u6cd5\u3092\u3044\u3064\u958b\u59cb\u3059\u3079\u304d\u3067\u3059\u304b\uff1f<\/p>\n

HF\u306f\u3001\u6a19\u7684\u81e8\u5e8a\u8a66\u9a13\u304a\u3088\u3073\u6709\u5bb3\u4e8b\u8c61\u3092\u5236\u9650\u3059\u308b\u305f\u3081\u306e\u500b\u5225\u5316\u3055\u308c\u305f\u6cbb\u7642\u3092\u5fc5\u8981\u3068\u3059\u308b\u72ec\u7279\u306e\u81e8\u5e8a\u72b6\u6cc1\u3092\u8868\u3057\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u8a66\u9a13\u306f\u3001\u5e83\u7bc4\u306aHF\u60a3\u8005\u96c6\u56e3\u30681\u3064\u306e\u7570\u306a\u308b\u81e8\u5e8a\u30b7\u30ca\u30ea\u30aa\u306b\u304a\u3051\u308bDOAC\u306e\u9078\u629e\u3059\u3079\u304d\u81e8\u5e8a\u5224\u65ad\u3092\u5b9a\u7fa9\u3059\u308b\u306e\u306b\u5f79\u7acb\u3061\u307e\u3059[3]\u3002<\/p>\n

*DOAC\uff1a2023 ISTH SSC\u306f\u3001\u6295\u4e0e\u69d8\u5f0f\u304a\u3088\u3073\u7279\u5b9a\u306e\u6a19\u7684\uff08\u4f8b\u3048\u3070\u3001\u7d4c\u53e3\u7b2cXIa\u56e0\u5b50\u963b\u5bb3\u5264\u3001\u975e\u7d4c\u53e3\u7b2cXIIa\u56e0\u5b50\u963b\u5bb3\u5264\uff09\u306b\u3088\u3063\u3066\u6297\u51dd\u56fa\u85ac\u3092\u8a18\u8f09\u3059\u308b\u3053\u3068\u3092\u63a8\u5968\u3057\u3066\u3044\u307e\u3059\u3002(5)<\/em><\/p>\n

\u53c2\u8003\u6587\u732e<\/em>:<\/p>\n

[1]<\/a>\u00a0SINIARSKI, A.et al. (2023) \u2018Blood coagulation disorders in heart failure: From basic science to clinical perspectives\u2019, Journal of Cardiac Failure, 29(4), pp. 517-526. doi:10.1016\/j.cardfail.2022.12.012.<\/p>\n

[2]<\/a>\u00a0Kim, J.H. et al. (2016) \u2019Coagulation abnormalities in heart failure: Pathophysiology and therapeutic implications\u2019, Current Heart Failure Reports, 13(6), pp. 319-328\u3002 doi:10.1007\/s11897-016-0308-6.<\/p>\n

[3]<\/a>\u00a0Paolillo, S.et al. (2020) \u2018Direct oral anticoagulants across the heart failure spectrum: The Precision Medicine Era\u2019, Heart Failure Reviews, 27(1), pp. 135-145. doi:10.1007\/s10741-020-09994-0.<\/p>\n

[4]<\/a>\u00a0Jackevicius, C.A. et al. (2021) \u2019Bleeding risk of direct oral anticoagulants in patients with heart failure and atrial fibrillation\u2019, Circulation: Cardiovascular Quality and Outcomes, 14(2). doi:10.1161\/circoutcomes.120.007230.<\/p>\n

[5] <\/a>\u00a0Barnes, G.D. et al. (2023) \u2019Recommendation on the nomenclature for anticoagulants: Updated communication from the International Society on Thrombosis and Haemostasis Scientific and standardization commitee on the control of anticoagulation\u2019, Journal of Thrombosis and Haemostasis, 21(5), pp. 1381-1384\u3002 doi:10.1016\/j.jtha.2023.02.008.<\/p>\n","protected":false},"excerpt":{"rendered":"

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(2023) \u2018Blood coagulation disorders in heart failure: From basic science to clinical perspectives\u2019, Journal of Cardiac Failure, 29(4), pp. 517-526. doi:10.1016\/j.cardfail.2022.12.012. [2]\u00a0Kim, J.H. et al. 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