{"id":143023,"date":"2019-04-30T05:42:31","date_gmt":"2019-04-30T05:42:31","guid":{"rendered":"https:\/\/labinsights.com\/acf_article\/%e9%9d%9e%e4%be%b5%e8%a5%b2%e7%9a%84%e5%87%ba%e7%94%9f%e5%89%8d%e6%a4%9c%e6%9f%bb%e6%8a%80%e8%a1%93%e3%81%ae%e9%80%b2%e5%8c%96\/"},"modified":"2026-01-20T09:53:59","modified_gmt":"2026-01-20T09:53:59","slug":"the-evolution-of-non-invasive-prenatal-test-technologies","status":"publish","type":"acf_article","link":"https:\/\/labinsights.com\/ja\/operations\/sequencing\/the-evolution-of-non-invasive-prenatal-test-technologies\/","title":{"rendered":"\u975e\u4fb5\u8972\u7684\u51fa\u751f\u524d\u691c\u67fb\u6280\u8853\u306e\u9032\u5316"},"content":{"rendered":"<p>\u598a\u5a66\u5065\u8a3a\u306f\u4e00\u822c\u7684\u306b\u5e78\u798f\u306a\u6a5f\u4f1a\u3067\u3042\u308b\u304c\u3001\u305d\u306e\u53cd\u9762\u3001\u3069\u306e\u598a\u5a20\u306b\u3082\u67d3\u8272\u4f53\u7570\u5e38\u306e\u30ea\u30b9\u30af\u304c\u4f34\u3046\u3053\u3068\u304b\u3089\u3001\u591a\u304f\u306e\u5973\u6027\u304c\u4f9d\u7136\u3068\u3057\u3066\u4e0d\u5b89\u3092\u611f\u3058\u3066\u3044\u308b\u3002\u5e78\u3044\u306b\u3082\u3001\u975e\u4fb5\u8972\u7684\u51fa\u751f\u524d\u691c\u67fb\u6280\u8853\uff08NIPT\uff09 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style=\"font-family: Inter !important; font-weight: 500 !important; font-size: 28px !important; line-height: 36px !important; letter-spacing: 0px !important;\"> cfDNA\u3078\u306e\u30a2\u30d7\u30ed\u30fc\u30c1<\/h2>\n<p>\u3042\u3089\u3086\u308b\u65b0\u305f\u306a\u767a\u898b\u3068\u540c\u69d8\u306b\u3001NIPT\u306b\u304a\u3044\u3066\u3082\u3001\u8907\u6570\u306e\u624b\u6cd5\u304c\u30b4\u30fc\u30eb\u30c9\u30b9\u30bf\u30f3\u30c0\u30fc\u30c9\u306e\u5730\u4f4d\u3092\u4e89\u3063\u3066\u3044\u308b\u3002\u3053\u308c\u3089\u306f\u3001\u5168\u30b2\u30ce\u30e0\u304a\u3088\u3073\u7279\u7570\u7684\u67d3\u8272\u4f53\u914d\u5217\u6c7a\u5b9a\u304b\u3089\u30de\u30a4\u30af\u30ed\u30a2\u30c3\u30bb\u30a4\u30d9\u30fc\u30b9\u306e\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u306b\u53ca\u3076\u3002\u6700\u3082\u521d\u671f\u306b\u7528\u3044\u3089\u308c\u305f\u6280\u8853\u306e\u3072\u3068\u3064\u306f\u3001\u8d85\u4e26\u5217\uff08\u300c\u30b7\u30e7\u30c3\u30c8\u30ac\u30f3\u300d\uff09\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u3067\u3042\u308b\u3002\u3053\u306e\u65b9\u6cd5\u306f\u76ee\u7684\u306e\u9818\u57df\u3092\u6a19\u7684\u3068\u3059\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u6bcd\u4f53\u8840\u6f3f\u4e2d\u306b\u5b58\u5728\u3059\u308b\u5168\u3066\u306ecfDNA\u65ad\u7247\u306e\u5168\u30b2\u30ce\u30e0\u3092\u8a55\u4fa1\u3059\u308b\u3002\u5168\u30b2\u30ce\u30e0\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0[6]\u3067\u306f\u3001\u6570\u5343\u4e07\u500b\u306e\u914d\u5217\u8aad\u307f\u53d6\u308a\u304c\u4f4d\u7f6e\u5408\u308f\u305b\u3055\u308c\u3001\u30d2\u30c8\u53c2\u7167\u30e9\u30a4\u30d6\u30e9\u30ea\u306b\u5bfe\u3057\u3066\u30de\u30c3\u30d4\u30f3\u30b0\u3055\u308c\u3066\u3001\u5f97\u3089\u308c\u305f\u30c7\u30fc\u30bf\u3092\u5143\u306e\u67d3\u8272\u4f53\u3068\u4e00\u81f4\u3055\u305b\u308b\u3002\u305d\u3057\u3066\u3001\u30de\u30c3\u30d4\u30f3\u30b0\u3055\u308c\u305f\u30c7\u30fc\u30bf\u304c\u8a08\u6570\u3055\u308c\u3066\u3001\u80ce\u5150\u304c\u67d3\u8272\u4f53\u7570\u5e38\u3092\u6709\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u5224\u5b9a\u3059\u308b\u3002<figure id=\"attachment_83546\" aria-describedby=\"caption-attachment-83546\" style=\"width: 689px\" class=\"wp-caption alignnone\"><img fetchpriority=\"high\" decoding=\"async\" class=\" size-full wp-image-83546\" src=\"\/wp-content\/uploads\/2019\/04\/nipt1-3fc.png\" alt=\"1\" width=\"689\" height=\"388\" data-caption=\"Massive parallel sequencing assesses whole genome of all cfDNA in maternal blood\" data-entity-type=\"file\" data-entity-uuid=\"7f55ab43-d043-4a7b-8dab-4c60690b3e86\" title=\"\" srcset=\"https:\/\/labinsights.com\/app\/uploads\/2019\/04\/nipt1-3fc.png 1632w, https:\/\/labinsights.com\/app\/uploads\/2019\/04\/nipt1-3fc-302x170.png 302w, https:\/\/labinsights.com\/app\/uploads\/2019\/04\/nipt1-3fc-1024x577.png 1024w, https:\/\/labinsights.com\/app\/uploads\/2019\/04\/nipt1-3fc-768x432.png 768w, https:\/\/labinsights.com\/app\/uploads\/2019\/04\/nipt1-3fc-1536x865.png 1536w\" sizes=\"(max-width: 689px) 100vw, 689px\" \/><figcaption id=\"caption-attachment-83546\" class=\"wp-caption-text\">\u5927\u898f\u6a21\u4e26\u5217\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u306b\u3088\u308b\u6bcd\u4f53\u8840\u6db2\u4e2d\u306e\u5168\u904a\u96e2DNA\u306e\u5168\u30b2\u30ce\u30e0\u3092\u89e3\u6790<\/figcaption><\/figure> 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id=\"attachment_83555\" aria-describedby=\"caption-attachment-83555\" style=\"width: 657px\" class=\"wp-caption alignnone\"><img decoding=\"async\" class=\" size-full wp-image-83555\" src=\"\/wp-content\/uploads\/2019\/04\/nipt2_0-5c9.png\" alt=\"2\" width=\"657\" height=\"377\" data-caption=\"Microarray analysis versus sequencing for detection of digital analysis of selected regions\" data-entity-type=\"file\" data-entity-uuid=\"e15d017f-fbd2-4077-8080-e565e8b3ea07\" title=\"\" srcset=\"https:\/\/labinsights.com\/app\/uploads\/2019\/04\/nipt2_0-5c9.png 1173w, https:\/\/labinsights.com\/app\/uploads\/2019\/04\/nipt2_0-5c9-302x173.png 302w, https:\/\/labinsights.com\/app\/uploads\/2019\/04\/nipt2_0-5c9-1024x588.png 1024w, https:\/\/labinsights.com\/app\/uploads\/2019\/04\/nipt2_0-5c9-768x441.png 768w\" sizes=\"(max-width: 657px) 100vw, 657px\" \/><figcaption id=\"caption-attachment-83555\" 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style=\"margin: 0in 0in 8pt;\"><em>\u53c2\u8003\u6587\u732e\uff1a<\/em><\/p>\n<p><a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/nejmoa043693\" target=\"_blank\" rel=\"noopener\">[1]<\/a> Malone, D.F., et al., (2005).First-Trimester or Second-Trimester Screening, or Both, for Down&#8217;s Syndrome.The New England journal of medicine.353(19), pp.2001-2011.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4325570\/\" target=\"_blank\" rel=\"noopener\">[2]<\/a>\u00a0Li, S.W., et al., (2015).The assessment of combined first trimester screening in women of advanced maternal age in an Asian cohort.\u00a0Singapore medical journal, 56(1), pp.47-52.<br \/>\n<a href=\"https:\/\/www.degruyter.com\/view\/journals\/dx\/2\/3\/article-p141.xml\" target=\"_blank\" rel=\"noopener\">[3] <\/a>\u00a0Kotsopoulou, I., et al., (2015).Non-invasive prenatal testing (NIPT): limitations on the way to become diagnosis,\u00a0Diagnosis,\u00a0 2(3), pp.141-158.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4886648\/\" target=\"_blank\" rel=\"noopener\">[4]<\/a>\u00a0Taglauer, E.S., et al., (2014).Review: cell-free fetal DNA in the maternal circulation as an indication of placental health and disease.\u00a0Placenta, 35 Suppl(Suppl), S64-S68.<br \/>\n<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0015028203028991\" target=\"_blank\" rel=\"noopener\">[5]<\/a> Wataganara, T., et al., (2004).Cell-free fetal DNA levels in maternal plasma after elective first-trimester termination of pregnancy.Fertility and Sterility, 81(3), pp.638-644.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3655220\/\" target=\"_blank\" rel=\"noopener\">[6] <\/a>\u00a0Swanson, A., et al.,\u00a0(2013).Non-invasive Prenatal Testing: Technologies, Clinical Assays and Implementation Strategies for Women&#8217;s Healthcare Practitioners.\u00a0Current genetic medicine reports, 1(2), pp.113-121.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3893900\/\" target=\"_blank\" rel=\"noopener\">[7] <\/a>\u00a0Norwitz, E.R., &#038; Levy, B.(2013).Noninvasive prenatal testing: the future is now.\u00a0Reviews in obstetrics &#038; gynecology, 6(2), pp.48-62.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4851803\/\" target=\"_blank\" rel=\"noopener\">[8] <\/a>\u00a0Kim, S., et L.,\u00a0(2016).Comparison of two high-throughput semiconductor chip sequencing platforms in noninvasive prenatal testing for Down syndrome in early pregnancy.\u00a0BMC medical genomics, 9(1), pp.22.<br \/>\n<a href=\"https:\/\/www.karger.com\/article\/FullText\/367626\" target=\"_blank\" rel=\"noopener\">[9]<\/a> Juneau, K., et al., (2014).Microarray-Based Cell-Free DNA Analysis Improved Noninvasive Prenatal Testing.Fetal Diagnosis and Therapy, 36, pp.282-286.<br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/s41598-018-22606-0\" target=\"_blank\" rel=\"noopener\">[10]<\/a> Dahl, F., et al., (2018).Imaging single DNA molecules for high precision NIPT.Scientific Reports, 8, 4549.<br \/>\n<a href=\"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/epdf\/10.1111\/1471-0528.15022\" target=\"_blank\" rel=\"noopener\">[11]<\/a> Cheng YKY., et al., (2018).\u00a0\u00a0Women\u2019s preference for non-invasive prenatal DNA testing versus chromosomal microarray after screening for Down syndrome: a prospective study.BJOG, 125, pp.451-459. <\/p>\n<hr \/>\n<p style=\"margin: 0in 0in 8pt;\"><em>\u3053\u306e\u8a18\u4e8b\u306f\u3001\u30bf\u30a4\u30fb\u30d0\u30f3\u30b3\u30af\u3067\u958b\u50ac\u3055\u308c\u305f2018 NIPT Forum Asia\u306b\u3066\u767a\u8868\u3055\u308c\u305f\u300c\u81e8\u5e8a\u7684\u610f\u7fa9\u3092\u6709\u3059\u308bNIPT\u6280\u8853\u306e\u9032\u5316\u300d\u304a\u3088\u3073\u300c\u6700\u65b0\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3068cfDNA\u691c\u67fb\u306e\u5c0e\u5165\u30e2\u30c7\u30eb\u300d\u3092\u5143\u306b\u4f5c\u6210\u3055\u308c\u305f\u3002<\/em><\/p>\n<p 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\u53c2\u8003\u6587\u732e\uff1a [1] Malone, D.F., et al., (2005).First-Trimester or Second-Trimester Screening, or Both, for Down&#8217;s Syndrome.The New England journal of medicine.353(19), pp.2001-2011. 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