{"id":143045,"date":"2019-04-30T03:25:00","date_gmt":"2019-04-30T03:25:00","guid":{"rendered":"https:\/\/labinsights.com\/acf_article\/%e4%b8%ad%e5%9b%bd%e3%81%a7ctdna%e3%81%8c%e6%9c%80%e9%ab%98%e6%ad%bb%e4%ba%a1%e7%8e%87%e3%81%ae%e3%81%8c%e3%82%93%e3%81%a8%e3%81%ae%e9%97%98%e3%81%84%e3%81%ab%e6%96%b0%e3%81%9f%e3%81%aa%e8%87%aa\/"},"modified":"2026-01-20T11:08:05","modified_gmt":"2026-01-20T11:08:05","slug":"ctdna-provides-new-confidence-in-fight-against-chinas-deadliest-cancer","status":"publish","type":"acf_article","link":"https:\/\/labinsights.com\/ja\/disease-area\/oncology\/ctdna-provides-new-confidence-in-fight-against-chinas-deadliest-cancer\/","title":{"rendered":"\u4e2d\u56fd\u3067ctDNA\u304c\u6700\u9ad8\u6b7b\u4ea1\u7387\u306e\u304c\u3093\u3068\u306e\u95d8\u3044\u306b\u65b0\u305f\u306a\u81ea\u4fe1\u3092\u3082\u305f\u3089\u3059"},"content":{"rendered":"<p>\u80ba\u304c\u3093\u306f\u00a0\u4e2d\u56fd\u3067\u6700\u3082\u591a\u3044\u304c\u3093\u00a0[1]\u3067\u3042\u308a\u3001\u6700\u3082\u81f4\u6b7b\u7387\u304c\u9ad8\u3044\u3002\u591a\u304f\u306e\u6b27\u7c73\u8af8\u56fd\u3068\u306f\u7570\u306a\u308a\u3001\u80ba\u304c\u3093\u8a3a\u65ad\u306e\u6570\u306f\u5897\u52a0\u3057\u7d9a\u3051\u3066\u3044\u308b\u3002\u00a0ctDNA\u6280\u8853\u3092\u5229\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u60a3\u8005\u30b1\u30a2\u3068\u8ee2\u5e30\u3092\u5927\u5e45\u306b\u6539\u5584\u3059\u308b\u6a5f\u4f1a\u304c\u5f97\u3089\u308c\u308b\u3002\u5f93\u6765\u3001\u304c\u3093\u8a3a\u65ad\u3092\u78ba\u8a8d\u3059\u308b\u305f\u3081\u306b\u3001\u7591\u308f\u3057\u3044\u764c\u6027\u816b\u760d\u304c\u751f\u691c\u3055\u308c\u3001\u7d44\u7e54\u304c\u30e9\u30dc\u533b\u5b66\u30c1\u30fc\u30e0\u306b\u3088\u3063\u3066\u8a3a\u65ad\u306e\u305f\u3081\u306b\u9001\u3089\u308c\u3066\u3044\u305f\u3002\u3057\u304b\u3057\u3001\u305f\u3063\u305f\u3072\u3068\u3064\u306e\u5c0f\u3055\u306a\u691c\u4f53\u306e\u307f\u3067\u304c\u3093\u3092\u5224\u5b9a\u3059\u308b\u3053\u3068\u306f\u8aa4\u8a3a\u3092\u62db\u304f\u304a\u305d\u308c\u304c\u3042\u308a\u3001\u7279\u306b\u80ba\u304c\u3093\u3067\u306f\u3001\u5e38\u306b\u7d44\u7e54\u751f\u691c\u3092\u7e70\u308a\u8fd4\u3057\u884c\u3048\u308b\u3068\u306f\u9650\u3089\u306a\u3044\u3002\u80ba\u304c\u3093\u306e\u6cbb\u7642\u3092\u53d7\u3051\u305f\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u7d44\u7e54\u751f\u691c\u306e\u518d\u5b9f\u65bd\u306f\u56f0\u96e3\u3092\u4f34\u3046\u5834\u5408\u304c\u3042\u308a\u3001\u4fb5\u8972\u7684\u51e6\u7f6e\u306b\u5185\u5728\u3059\u308b\u30ea\u30b9\u30af\u3092\u4f34\u3046\u3002\u9069\u5207\u306a\u5c02\u9580\u77e5\u8b58\u3092\u6709\u3059\u308b\u30e9\u30dc\u306f\u3001\u305d\u306e\u3088\u3046\u306a\u72b6\u6cc1\u306b\u304a\u3044\u3066\u533b\u5e2b\u306b\u9b45\u529b\u7684\u306a\u4ee3\u66ff\u624b\u6bb5\u3092\u63d0\u4f9b\u3067\u304d\u308b\u3002\u5faa\u74b0\u816b\u760dDNA\uff08ctDNA\uff09\u30ec\u30d9\u30eb\u3092\u6e2c\u5b9a\u3059\u308b\u6db2\u4f53\u751f\u691c\u306f\u3001\u4fb5\u8972\u6027\u304c\u4f4e\u304f\u3001\u751f\u691c\u306b\u95a2\u9023\u3059\u308b\u5408\u4f75\u75c7\u3092\u56de\u907f\u3067\u304d\u308b\u3002ctDNA\u304b\u3089\u5f97\u3089\u308c\u305f\u907a\u4f1d\u7684\u304a\u3088\u3073\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u30c7\u30fc\u30bf\u3092\u6d3b\u7528\u3057\u3001\u7814\u7a76\u30c1\u30fc\u30e0\u306f\u816b\u760d\u5c02\u9580\u533b\u306b\u5bfe\u3057\u3001\u304c\u3093\u306e\u907a\u4f1d\u5b50\u578b\u3068\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u306e\u6319\u52d5\u306b\u95a2\u3059\u308b\u9ad8\u54c1\u8cea\u306a\u7cbe\u5bc6\u30c7\u30fc\u30bf\u3092\u63d0\u4f9b\u3057\u3001\u60a3\u8005\u306e\u75be\u60a3\u7ba1\u7406\u3092\u3088\u308a\u9069\u5207\u306b\u884c\u3048\u308b\u3088\u3046\u3067\u304d\u308b\u3002<\/p>\n<h2 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T790M\u5909\u7570\u3092\u6709\u3059\u308b[4]\u3002Wakelee\u3089\u306f\u3001ASCO 2016\u3067\u306e\u767a\u8868[5]\u3067\u3001\u00a0\u8840\u6f3f\u53ca\u3073\u5c3fEGFR\u5206\u6790\u304c\u3053\u308c\u3089\u306e\u5909\u7570\u3092\u6b63\u78ba\u306b\u691c\u51fa\u3057\u3001\u751f\u691c\u304c\u816b\u760d\u306e\u4e0d\u5747\u4e00\u6027\u306b\u8d77\u56e0\u3057\u306a\u3044\u5834\u5408\u306b\u305d\u308c\u3089\u3092\u7279\u5b9a\u3057\u5f97\u308b\u3053\u3068\u3092\u5b9f\u8a3c\u3057\u305f\u3002\u00a0\u307e\u305fZheng\u3089\u306f\u3001ctDNA\u306f\u81e8\u5e8a\u75be\u60a3\u9032\u884c\u306e\u4e2d\u592e\u50242.2\u30f6\u6708\u524d\u306b\u305d\u306e\u3088\u3046\u306a\u60a3\u8005\u3092\u540c\u5b9a\u3059\u308b\u3053\u3068\u3092\u53ef\u80fd\u306b\u3059\u308b[4]\u3068\u5b9f\u8a3c\u3057\u305f\u3002<\/p>\n<h2 style=\"font-family: Inter !important; font-weight: 500 !important; font-size: 28px !important; line-height: 36px !important; letter-spacing: 0px !important;\">\u3059\u3079\u3066\u306e\u65b0\u4e16\u4ee3\u306e\u6280\u8853\u3068\u540c\u69d8\u306b\u3001\u533b\u9662\u3068\u30e9\u30dc\u306e\u9593\u306b\u3088\u308a\u7dca\u5bc6\u306a\u95a2\u4fc2\u3092\u7bc9\u304f\u305f\u3081<\/h2>\n<p>\u3001ctDNA\u691c\u67fb\u00a0\u3092\u3044\u3064\u9069\u7528\u3059\u308b\u304b\u3001\u7d50\u679c\u3092\u5206\u6790\u304a\u3088\u3073\u89e3\u91c8\u3059\u308b\u65b9\u6cd5\u3092\u628a\u63e1\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3042\u308b\u3002\u6700\u65b0\u306e\u7814\u7a76\u306b\u95a2\u3059\u308b\u6700\u65b0\u60c5\u5831\u3092\u6271\u3044\u3001\u8cea\u306e\u9ad8\u3044\u7cbe\u5bc6\u5206\u6790\u3092\u63d0\u4f9b\u3059\u308b\u305f\u3081\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3092\u53d7\u3051\u305f\u691c\u67fb\u30c1\u30fc\u30e0\u306b\u30a2\u30af\u30bb\u30b9\u3059\u308b\u3053\u3068\u3067\u3001\u816b\u760d\u533b\u306f\u60a3\u8005\u306e\u75be\u60a3\u3092\u3088\u308a\u826f\u597d\u306b\u7ba1\u7406\u3067\u304d\u308b\u3002ctDNA\u89e3\u6790\u306b\u3088\u308a\u3001\u60a3\u8005\u306e49%\u3067FDA\u627f\u8a8d\u85ac\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u4f7f\u7528\u3067\u304d\u308b\u304c\u3093\u5909\u7570\u3092\u7279\u5b9a\u3067\u304d\u308b[6]\u3002\u81e8\u5e8a\u691c\u67fb\u30e9\u30dc\u306e\u5c02\u9580\u691c\u67fb\u6280\u5e2b\u306f\u3001\u6db2\u4f53\u751f\u691c\u304c\u6700\u3082\u9069\u5207\u306a\u8a3a\u65ad\u30c4\u30fc\u30eb\u3068\u306a\u308b\u6642\u671f\u3092\u5224\u65ad\u3059\u308b\u305f\u3081\u306b\u3001\u816b\u760d\u533b\u3068\u9023\u643a\u3057\u3066\u4f5c\u696d\u3057\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3002\u6211\u3005\u306f\u3001\u8a3a\u65ad\u6642\u3060\u3051\u3067\u306a\u304f\u75be\u60a3\u5168\u4f53\u3092\u901a\u3057\u3066\u60a3\u8005\u306b\u5bfe\u3059\u308b\u500b\u5225\u306b\u5408\u308f\u305b\u305f\u6cbb\u7642\u306e\u63d0\u4f9b\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u308b\u3002ctDNA\u306f\u3001\u304c\u3093\u306e\u907a\u4f1d\u7684\u69cb\u6210\u3068\u00a0\u56fa\u6709\u306e\u7570\u8cea\u6027\u306b\u95a2\u3059\u308b\u60c5\u5831\u3092\u63d0\u4f9b\u3059\u308b\u3002\u307e\u305f\u3001\u518d\u767a\u306e\u30ea\u30b9\u30af\u3084\u5168\u751f\u5b58\u7387\u306a\u3069\u3001\u4e88\u5f8c\u306e\u624b\u304c\u304b\u308a\u306b\u306a\u308b\u5834\u5408\u3082\u3042\u308b\u3002\u30e9\u30dc\u304b\u3089\u306e\u78ba\u56fa\u305f\u308b\u6b63\u78ba\u306a\u60c5\u5831\u306b\u3088\u308a\u3001\u816b\u760d\u5c02\u9580\u533b\u306f\u3059\u3050\u306b\u3001\u60a3\u8005\u304b\u3089\u6295\u3052\u304b\u3051\u3089\u308c\u308b\u6700\u3082\u96e3\u3057\u3044\u8cea\u554f\u306e\u6570\u3005\u306b\u3001\u3088\u308a\u78ba\u4fe1\u3092\u6301\u3063\u3066\u660e\u78ba\u306b\u7b54\u3048\u3089\u308c\u308b\u3088\u3046\u306b\u306a\u308b\u3002<\/p>\n<p><em>\u53c2\u8003\u6587\u732e\uff1a<\/em> <\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4367759\/\" target=\"_blank\" rel=\"noopener\">[1]<\/a>\u00a0Zhou, C., 2014. \u4e2d\u56fd\u306b\u304a\u3051\u308b\u80ba\u304c\u3093\u306e\u5206\u5b50\u75ab\u5b66\uff1a\u6700\u65b0\u52d5\u5411\u00a0<i>\u8ee2\u79fb\u578b\u80ba\u304c\u3093\u7814\u7a76<\/i>, 3(5), pp.270-279.<br \/>\n<a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMra1706174\" target=\"_blank\" rel=\"noopener\">[2]<\/a> Corcoran, B.R., Chabner A.B., 2018. \u304c\u3093\u6cbb\u7642\u306b\u5bfe\u3059\u308b\u7121\u7d30\u80deDNA\u89e3\u6790\u306e\u5fdc\u7528<em>New England Journal of Medicine<\/em>, 379, pp.1754-1765<br \/>\n<a href=\"https:\/\/cancerdiscovery.aacrjournals.org\/content\/7\/12\/1394\" target=\"_blank\" rel=\"noopener\">[3]<\/a> Chaudhuri, A.A, et al., 2018. \u5faa\u74b0\u816b\u760dDNA\u30d7\u30ed\u30d5\u30a1\u30a4\u30ea\u30f3\u30b0\u306b\u3088\u308b\u3001\u9650\u5c40\u578b\u80ba\u764c\u306b\u304a\u3051\u308b\u5206\u5b50\u5b66\u7684\u6b8b\u5b58\u75c5\u5909\u306e\u65e9\u671f\u691c\u51fa\u3002<em>American Association for Cancer Research<\/em>, 7(12), pp.1394-1403.<br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/srep20913\" target=\"_blank\" rel=\"noopener\">[4]<\/a> Zheng, X.Y, et al., 2016. \u8840\u6f3f<em>EGFR<\/em> T790M ctDNA\u72b6\u614b\u306b\u3088\u308b\u3001\u5f8c\u5929\u6027EGFR-TKI\u8010\u6027\u3092\u6709\u3059\u308b\u9032\u884c\u6027NSCLC\u60a3\u8005\u306b\u304a\u3051\u308b\u81e8\u5e8a\u8ee2\u5e30\u3078\u306e\u95a2\u9023\u6027\u3002 <em>Scientific Reports<\/em>, 6, 20913.<br \/>\n<a href=\"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2016.34.15_suppl.9001\" target=\"_blank\" rel=\"noopener\">[5]<\/a> Wakelee, A.H., et al., 2016.\u00a0\u30ed\u30b7\u30ec\u30c1\u30cb\u30d6\u6cbb\u7642\u3092\u53d7\u3051\u305f\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\uff08pts\uff09\u306e\u5c3f\u3001\u8840\u6f3f\u3001\u816b\u760d\u7d44\u7e54\u306e\u5bfe\u5fdc\u691c\u4f53\u306b\u304a\u3051\u308b\u4e0a\u76ae\u6210\u9577\u56e0\u5b50\u53d7\u5bb9\u4f53\uff08EGFR\uff09\u907a\u4f1d\u5b50\u578b\u89e3\u6790<em>Journal of Clinical Oncology<\/em>, 34(15) <em>supplementary<\/em>, pp.9001-9001.<br \/>\n<a href=\"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2016.34.18_suppl.LBA11501\" target=\"_blank\" rel=\"noopener\">[6]<\/a> Zill, A.O., et al., 2016.\u00a0\u5faa\u74b0\u816b\u760dDNA\u306e\u81e8\u5e8a\u7684\u6b21\u4e16\u4ee3\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u89e3\u6790\u306b\u3088\u308b\u3001\u9032\u884c\u671f\u304c\u3093\u60a3\u800515,000\u4eba\u4ee5\u4e0a\u3067\u306e\u4f53\u7d30\u80de\u306e\u30b2\u30ce\u30df\u30c3\u30af\u30e9\u30f3\u30c9\u30b9\u30b1\u30fc\u30d7\u3002<em>Journal of Clinical Oncology<\/em>, 34(18),<em> supplementary,<\/em>\u00a0LBA11501<\/p>\n<hr \/>\n<p> <em>\u3053\u306e\u8a18\u4e8b\u306f\u3001\u4e2d\u56fd\u306e\u8607\u5dde\u3067\u958b\u50ac\u3055\u308c\u305fBelt and Road Diagnostic Summit Forum 2018\u3067\u306e\u30d7\u30ec\u30bc\u30f3\u30c6\u30fc\u30b7\u30e7\u30f3\u300c\u00a0Conquering Cancer: ctDNA\u2019s application in NSCLC\u300d\u306b\u57fa\u3065\u304f\u3002<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u80ba\u304c\u3093\u306f\u00a0\u4e2d\u56fd\u3067\u6700\u3082\u591a\u3044\u304c\u3093\u00a0[1]\u3067\u3042\u308a\u3001\u6700\u3082\u81f4\u6b7b\u7387\u304c\u9ad8\u3044\u3002\u591a\u304f\u306e\u6b27\u7c73\u8af8\u56fd\u3068\u306f\u7570\u306a\u308a\u3001\u80ba\u304c\u3093\u8a3a\u65ad\u306e\u6570\u306f\u5897\u52a0\u3057\u7d9a\u3051\u3066\u3044\u308b\u3002\u00a0ctDNA\u6280\u8853\u3092\u5229\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u60a3\u8005\u30b1\u30a2\u3068\u8ee2\u5e30\u3092\u5927\u5e45\u306b\u6539\u5584\u3059\u308b\u6a5f\u4f1a\u304c\u5f97\u3089\u308c\u308b\u3002\u5f93\u6765\u3001\u304c\u3093\u8a3a\u65ad\u3092\u78ba\u8a8d\u3059\u308b\u305f\u3081\u306b\u3001\u7591\u308f\u3057\u3044\u764c\u6027\u816b\u760d\u304c\u751f\u691c\u3055\u308c\u3001\u7d44\u7e54\u304c\u30e9\u30dc\u533b\u5b66\u30c1\u30fc\u30e0\u306b\u3088\u3063\u3066\u8a3a\u65ad\u306e\u305f\u3081\u306b\u9001\u3089\u308c\u3066\u3044\u305f\u3002\u3057\u304b\u3057\u3001\u305f\u3063\u305f\u3072\u3068\u3064\u306e\u5c0f\u3055\u306a\u691c\u4f53\u306e\u307f\u3067\u304c\u3093\u3092\u5224\u5b9a\u3059\u308b\u3053\u3068\u306f\u8aa4\u8a3a\u3092\u62db\u304f\u304a\u305d\u308c\u304c\u3042\u308a\u3001\u7279\u306b\u80ba\u304c\u3093\u3067\u306f\u3001\u5e38\u306b\u7d44\u7e54\u751f\u691c\u3092\u7e70\u308a\u8fd4\u3057\u884c\u3048\u308b\u3068\u306f\u9650\u3089\u306a\u3044\u3002\u80ba\u304c\u3093\u306e\u6cbb\u7642\u3092\u53d7\u3051\u305f\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u7d44\u7e54\u751f\u691c\u306e\u518d\u5b9f\u65bd\u306f\u56f0\u96e3\u3092\u4f34\u3046\u5834\u5408\u304c\u3042\u308a\u3001\u4fb5\u8972\u7684\u51e6\u7f6e\u306b\u5185\u5728\u3059\u308b\u30ea\u30b9\u30af\u3092\u4f34\u3046\u3002\u9069\u5207\u306a\u5c02\u9580\u77e5\u8b58\u3092\u6709\u3059\u308b\u30e9\u30dc\u306f\u3001\u305d\u306e\u3088\u3046\u306a\u72b6\u6cc1\u306b\u304a\u3044\u3066\u533b\u5e2b\u306b\u9b45\u529b\u7684\u306a\u4ee3\u66ff\u624b\u6bb5\u3092\u63d0\u4f9b\u3067\u304d\u308b\u3002\u5faa\u74b0\u816b\u760dDNA\uff08ctDNA\uff09\u30ec\u30d9\u30eb\u3092\u6e2c\u5b9a\u3059\u308b\u6db2\u4f53\u751f\u691c\u306f\u3001\u4fb5\u8972\u6027\u304c\u4f4e\u304f\u3001\u751f\u691c\u306b\u95a2\u9023\u3059\u308b\u5408\u4f75\u75c7\u3092\u56de\u907f\u3067\u304d\u308b\u3002ctDNA\u304b\u3089\u5f97\u3089\u308c\u305f\u907a\u4f1d\u7684\u304a\u3088\u3073\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u30c7\u30fc\u30bf\u3092\u6d3b\u7528\u3057\u3001\u7814\u7a76\u30c1\u30fc\u30e0\u306f\u816b\u760d\u5c02\u9580\u533b\u306b\u5bfe\u3057\u3001\u304c\u3093\u306e\u907a\u4f1d\u5b50\u578b\u3068\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u306e\u6319\u52d5\u306b\u95a2\u3059\u308b\u9ad8\u54c1\u8cea\u306a\u7cbe\u5bc6\u30c7\u30fc\u30bf\u3092\u63d0\u4f9b\u3057\u3001\u60a3\u8005\u306e\u75be\u60a3\u7ba1\u7406\u3092\u3088\u308a\u9069\u5207\u306b\u884c\u3048\u308b\u3088\u3046\u3067\u304d\u308b\u3002 \u30d0\u30a4\u30a2\u30eb\u306e\u8840\u306b\u5b58\u5728\u3059\u308b\u53ef\u80fd\u6027\u306e\u89e3\u653e ctDNA\u306e\u534a\u6e1b\u671f\u306f1\u6642\u9593\u4ee5\u4e0b\u3068\u77ed\u3044\u305f\u3081\u3001\u6cbb\u7642\u306b\u5bfe\u3059\u308b\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u306e\u816b\u760d\u8ca0\u8377\u3092\u6b63\u78ba\u306b\u793a\u3059\u6307\u6a19\u3068\u306a\u308a\u5f97\u308b[2]\u3002\u3053\u306e\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u60c5\u5831\u306b\u30a2\u30af\u30bb\u30b9\u3059\u308b\u3053\u3068\u3067\u3001\u6cbb\u7642\u30c1\u30fc\u30e0\u306f\u6b8b\u5b58\u75c5\u5909\u3092\u65e9\u671f\u306b\u691c\u51fa\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u5b9f\u969b\u3001\u9650\u5c40\u578b\u80ba\u304c\u3093\u60a3\u8005\u306e\u00a072%\u306b\u304a\u3044\u3066\u3001ctDNA\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u653e\u5c04\u7dda\u753b\u50cf\u6cd5\u306e\u307f\u3088\u308a\u30825.2\u30f6\u6708\u65e9\u304f\u6b8b\u5b58\u75c5\u5909\u3092\u540c\u5b9a\u3067\u304d\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b[3]\u3002\u4f8b\u3048\u3070\u3001\u4e0a\u76ae\u6210\u9577\u56e0\u5b50\u53d7\u5bb9\u4f53\uff08EGFR\uff09\u5909\u7570\u967d\u6027\u306e\u975e\u5c0f\u7d30\u80de\u80ba\u304c\u3093\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u00a0\u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\u963b\u5bb3\u5264\u6cbb\u7642\u306b\u5bfe\u3059\u308b\u65b0\u305f\u306a\u8010\u6027\u306e\u51fa\u73fe\u306f\u3001\u75be\u60a3\u306e\u907a\u4f1d\u7684\u9032\u5316\u3092\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u76e3\u8996\u3059\u308b\u305f\u3081\u306bctDNA\u3092\u6d3b\u7528\u3059\u308b\u5225\u306e\u6a5f\u4f1a\u3092\u63d0\u4f9b\u3059\u308b\u3002\u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\u963b\u5bb3\u85ac\u306b\u3088\u308b\u6cbb\u7642\u3092\u53d7\u3051\u305f\u60a3\u8005\u306e\u534a\u6570\u304c\u3001EGFR T790M\u5909\u7570\u3092\u6709\u3059\u308b[4]\u3002Wakelee\u3089\u306f\u3001ASCO 2016\u3067\u306e\u767a\u8868[5]\u3067\u3001\u00a0\u8840\u6f3f\u53ca\u3073\u5c3fEGFR\u5206\u6790\u304c\u3053\u308c\u3089\u306e\u5909\u7570\u3092\u6b63\u78ba\u306b\u691c\u51fa\u3057\u3001\u751f\u691c\u304c\u816b\u760d\u306e\u4e0d\u5747\u4e00\u6027\u306b\u8d77\u56e0\u3057\u306a\u3044\u5834\u5408\u306b\u305d\u308c\u3089\u3092\u7279\u5b9a\u3057\u5f97\u308b\u3053\u3068\u3092\u5b9f\u8a3c\u3057\u305f\u3002\u00a0\u307e\u305fZheng\u3089\u306f\u3001ctDNA\u306f\u81e8\u5e8a\u75be\u60a3\u9032\u884c\u306e\u4e2d\u592e\u50242.2\u30f6\u6708\u524d\u306b\u305d\u306e\u3088\u3046\u306a\u60a3\u8005\u3092\u540c\u5b9a\u3059\u308b\u3053\u3068\u3092\u53ef\u80fd\u306b\u3059\u308b[4]\u3068\u5b9f\u8a3c\u3057\u305f\u3002 \u3059\u3079\u3066\u306e\u65b0\u4e16\u4ee3\u306e\u6280\u8853\u3068\u540c\u69d8\u306b\u3001\u533b\u9662\u3068\u30e9\u30dc\u306e\u9593\u306b\u3088\u308a\u7dca\u5bc6\u306a\u95a2\u4fc2\u3092\u7bc9\u304f\u305f\u3081 \u3001ctDNA\u691c\u67fb\u00a0\u3092\u3044\u3064\u9069\u7528\u3059\u308b\u304b\u3001\u7d50\u679c\u3092\u5206\u6790\u304a\u3088\u3073\u89e3\u91c8\u3059\u308b\u65b9\u6cd5\u3092\u628a\u63e1\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3042\u308b\u3002\u6700\u65b0\u306e\u7814\u7a76\u306b\u95a2\u3059\u308b\u6700\u65b0\u60c5\u5831\u3092\u6271\u3044\u3001\u8cea\u306e\u9ad8\u3044\u7cbe\u5bc6\u5206\u6790\u3092\u63d0\u4f9b\u3059\u308b\u305f\u3081\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3092\u53d7\u3051\u305f\u691c\u67fb\u30c1\u30fc\u30e0\u306b\u30a2\u30af\u30bb\u30b9\u3059\u308b\u3053\u3068\u3067\u3001\u816b\u760d\u533b\u306f\u60a3\u8005\u306e\u75be\u60a3\u3092\u3088\u308a\u826f\u597d\u306b\u7ba1\u7406\u3067\u304d\u308b\u3002ctDNA\u89e3\u6790\u306b\u3088\u308a\u3001\u60a3\u8005\u306e49%\u3067FDA\u627f\u8a8d\u85ac\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u4f7f\u7528\u3067\u304d\u308b\u304c\u3093\u5909\u7570\u3092\u7279\u5b9a\u3067\u304d\u308b[6]\u3002\u81e8\u5e8a\u691c\u67fb\u30e9\u30dc\u306e\u5c02\u9580\u691c\u67fb\u6280\u5e2b\u306f\u3001\u6db2\u4f53\u751f\u691c\u304c\u6700\u3082\u9069\u5207\u306a\u8a3a\u65ad\u30c4\u30fc\u30eb\u3068\u306a\u308b\u6642\u671f\u3092\u5224\u65ad\u3059\u308b\u305f\u3081\u306b\u3001\u816b\u760d\u533b\u3068\u9023\u643a\u3057\u3066\u4f5c\u696d\u3057\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3002\u6211\u3005\u306f\u3001\u8a3a\u65ad\u6642\u3060\u3051\u3067\u306a\u304f\u75be\u60a3\u5168\u4f53\u3092\u901a\u3057\u3066\u60a3\u8005\u306b\u5bfe\u3059\u308b\u500b\u5225\u306b\u5408\u308f\u305b\u305f\u6cbb\u7642\u306e\u63d0\u4f9b\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u308b\u3002ctDNA\u306f\u3001\u304c\u3093\u306e\u907a\u4f1d\u7684\u69cb\u6210\u3068\u00a0\u56fa\u6709\u306e\u7570\u8cea\u6027\u306b\u95a2\u3059\u308b\u60c5\u5831\u3092\u63d0\u4f9b\u3059\u308b\u3002\u307e\u305f\u3001\u518d\u767a\u306e\u30ea\u30b9\u30af\u3084\u5168\u751f\u5b58\u7387\u306a\u3069\u3001\u4e88\u5f8c\u306e\u624b\u304c\u304b\u308a\u306b\u306a\u308b\u5834\u5408\u3082\u3042\u308b\u3002\u30e9\u30dc\u304b\u3089\u306e\u78ba\u56fa\u305f\u308b\u6b63\u78ba\u306a\u60c5\u5831\u306b\u3088\u308a\u3001\u816b\u760d\u5c02\u9580\u533b\u306f\u3059\u3050\u306b\u3001\u60a3\u8005\u304b\u3089\u6295\u3052\u304b\u3051\u3089\u308c\u308b\u6700\u3082\u96e3\u3057\u3044\u8cea\u554f\u306e\u6570\u3005\u306b\u3001\u3088\u308a\u78ba\u4fe1\u3092\u6301\u3063\u3066\u660e\u78ba\u306b\u7b54\u3048\u3089\u308c\u308b\u3088\u3046\u306b\u306a\u308b\u3002 \u53c2\u8003\u6587\u732e\uff1a [1]\u00a0Zhou, C., 2014. \u4e2d\u56fd\u306b\u304a\u3051\u308b\u80ba\u304c\u3093\u306e\u5206\u5b50\u75ab\u5b66\uff1a\u6700\u65b0\u52d5\u5411\u00a0\u8ee2\u79fb\u578b\u80ba\u304c\u3093\u7814\u7a76, 3(5), pp.270-279. [2] Corcoran, B.R., Chabner A.B., 2018. \u304c\u3093\u6cbb\u7642\u306b\u5bfe\u3059\u308b\u7121\u7d30\u80deDNA\u89e3\u6790\u306e\u5fdc\u7528New England Journal of Medicine, 379, pp.1754-1765 [3] Chaudhuri, A.A, et al., 2018. \u5faa\u74b0\u816b\u760dDNA\u30d7\u30ed\u30d5\u30a1\u30a4\u30ea\u30f3\u30b0\u306b\u3088\u308b\u3001\u9650\u5c40\u578b\u80ba\u764c\u306b\u304a\u3051\u308b\u5206\u5b50\u5b66\u7684\u6b8b\u5b58\u75c5\u5909\u306e\u65e9\u671f\u691c\u51fa\u3002American Association for Cancer Research, 7(12), pp.1394-1403. [4] Zheng, X.Y, et al., 2016. \u8840\u6f3fEGFR T790M ctDNA\u72b6\u614b\u306b\u3088\u308b\u3001\u5f8c\u5929\u6027EGFR-TKI\u8010\u6027\u3092\u6709\u3059\u308b\u9032\u884c\u6027NSCLC\u60a3\u8005\u306b\u304a\u3051\u308b\u81e8\u5e8a\u8ee2\u5e30\u3078\u306e\u95a2\u9023\u6027\u3002 Scientific Reports, 6, 20913. 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