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Dr Tan\u306f\u3001\u73fe\u5728\u5f7c\u306e\u8a3a\u7642\u4e0b\u306b\u3042\u308b\u8ee2\u79fb\u6027\u660e\u7d30\u80de\u5b50\u5bae\u5185\u819c\u304c\u3093\u60a3\u8005\u306e\u4f8b\u3092\u6319\u3052\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u304c\u3093\u7a2e\u306f\u4e00\u822c\u7684\u306b\u5316\u5b66\u7642\u6cd5\u306b\u975e\u5e38\u306b\u5f37\u3044\u8010\u6027\u3092\u793a\u3059\u305f\u3081\u3001\u521d\u56de\u6cbb\u7642\u304b\u30893\u304b\u6708\u5f8c\u306b\u306f\u518d\u767a\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002NGS\u89e3\u6790\u306b\u3088\u308a\u3001\u3053\u306e\u60a3\u8005\u306e\u816b\u760d\u306b\u6bdb\u7d30\u8840\u7ba1\u62e1\u5f35\u6027\u904b\u52d5\u5931\u8abf\u75c7\u306b\u95a2\u9023\u3059\u308b\u7a81\u7136\u5909\u7570\u304c\u898b\u3064\u304b\u308a\u30011\u5e74\u534a\u4ee5\u4e0a\u306b\u308f\u305f\u3063\u3066\u75be\u60a3\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3067\u304d\u3066\u3044\u308b\u963b\u5bb3\u5264\u306e\u81e8\u5e8a\u8a66\u9a13\u306b\u53c2\u52a0\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u5f93\u6765\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308b\u540c\u69d8\u306e\u60a3\u8005\u3067\u306f\u3001\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\u304c\u901a\u5e386\u304b\u6708\u672a\u6e80\u3067\u3042\u308b\u3053\u3068\u3092\u8e0f\u307e\u3048\u308b\u3068\u3001\u3053\u306e\u53cd\u5fdc\u306f\u7279\u7b46\u3059\u3079\u304d\u3082\u306e\u3067\u3059\u3002\u60a3\u8005\u304c\u56fa\u6709\u306e\u8868\u73fe\u578b\u304a\u3088\u3073\u907a\u4f1d\u5b50\u578b\u3092\u793a\u3059\u3088\u3046\u306b\u306a\u308b\u306b\u3064\u308c\u3001\u8a3a\u65ad\u6642\u306b\u30d7\u30ed\u30d5\u30a1\u30a4\u30ea\u30f3\u30b0\u3092\u5b9f\u65bd\u3059\u308b\u5fc5\u8981\u6027\u304c\u9ad8\u307e\u3063\u3066\u3044\u307e\u3059\u3002Dr Tan\u306f\u3001\u533b\u5e2b\u304c\u6cbb\u7642\u6226\u7565\u306b\u304a\u3044\u3066\u3053\u3046\u3057\u305f\u4e0d\u5747\u4e00\u6027\u3092\u628a\u63e1\u3057\u306a\u3051\u308c\u3070\u3001\u6b63\u78ba\u306a\u6cbb\u7642\u3092\u63d0\u4f9b\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u306a\u3044\u3068\u7406\u89e3\u3057\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u5375\u5de3\u304c\u3093\u306b\u304a\u3051\u308b\u76f8\u540c\u7d44\u63db\u3048\u4e0d\u5168\uff08HRD\uff09\u306e\u5b58\u5728\u306f\u3001PARP\u963b\u5bb3\u5264\u306b\u3088\u308b\u6cbb\u7642\u3092\u60a3\u8005\u306b\u3068\u3063\u3066\u975e\u5e38\u306b\u52b9\u679c\u7684\u306a\u3082\u306e\u306b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u3057\u3066\u3001HRD\u306b\u7279\u6709\u306e\u7279\u5fb4\u306f\u3001\u5305\u62ec\u7684\u306a\u30b2\u30ce\u30e0\u30d7\u30ed\u30d5\u30a1\u30a4\u30ea\u30f3\u30b0\u306b\u3088\u3063\u3066\u306e\u307f\u816b\u760d\u30b2\u30ce\u30e0\u304b\u3089\u540c\u5b9a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002Dr Tan\u306f\u6b21\u306e\u3088\u3046\u306b\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002\u300c\u518d\u767a\u30fb\u96e3\u6cbb\u6027\u304c\u3093\u3068\u306f\u5225\u306b\u3001\u80ba\u304c\u3093\u3084\u5375\u5de3\u304c\u3093\u306a\u3069\u3001\u5305\u62ec\u7684\u306a\u30b2\u30ce\u30e0\u30d7\u30ed\u30d5\u30a1\u30a4\u30ea\u30f3\u30b0\u306e\u7d50\u679c\u304c\u6cbb\u7642\u7684\u5c64\u5225\u5316\u306b\u3068\u3063\u3066\u91cd\u8981\u3068\u306a\u308b\u75be\u60a3\u306e\u4e00\u6b21\u6cbb\u7642\u306e\u72b6\u6cc1\u306b\u304a\u3044\u3066\u3001\u00a0NGS\u306e\u91cd\u8981\u6027\u304c\u9ad8\u307e\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u8a8d\u8b58\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u300d\u30a2\u30b8\u30a2\u3067\u306eNGS\u306e\u65e9\u671f\u5c0e\u5165\u8005\u3068\u3057\u3066\u3001NCIS\u306e\u85ac\u7269\u958b\u767a\u30c1\u30fc\u30e0\u306f\u3001\u9069\u683c\u306a\u60a3\u8005\u3078\u7121\u511f\u3067\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u3092\u63d0\u4f9b\u3059\u308b\u305f\u3081\u306b\u3001\u521d\u671f\u6bb5\u968e\u306e\u81e8\u5e8a\u8a66\u9a13\u30e6\u30cb\u30c3\u30c8\u3067\u3042\u308bNCIS Developmental Therapeutics Unit\uff08DTU\uff09\u00a0\u3092\u8a2d\u7acb\u3057\u307e\u3057\u305f\u3002\u3055\u3089\u306bNCIS\u306f2014\u5e74\u306bIntegrated Molecular Profiling of Cancers\uff08IMAC\uff09\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u958b\u59cb\u3057\u3001\u5f53\u521d\u306f50\u907a\u4f1d\u5b50\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30d1\u30cd\u30eb\u3067\u3057\u305f\u304c\u3001\u73fe\u5728\u3067\u306f324\u907a\u4f1d\u5b50\u3092\u5bfe\u8c61\u3068\u3059\u308b\u898f\u6a21\u306b\u6210\u9577\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n
\u591a\u304f\u306eNGS\u7814\u7a76\u304c\u81e8\u5e8a\u7684\u6709\u52b9\u6027\u3092\u793a\u3059\u3053\u3068\u306b\u6210\u529f\u3057\u3066\u3044\u308b\u305f\u3081\u3001\u30b2\u30ce\u30df\u30af\u30b9\u306e\u5c02\u9580\u77e5\u8b58\u3092\u6301\u305f\u306a\u3044\u533b\u5e2b\u3067\u3082\u5206\u5b50\u816b\u760d\u75c7\u4f8b\uff08MTB\uff09\u306b\u53c2\u52a0\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002MTB\u3067\u306f\u3001\u89e3\u91c8\u304c\u56f0\u96e3\u306a\u5834\u5408\u304c\u3042\u308b\u73fe\u5b9f\u4e16\u754c\u306e\u60a3\u8005NGS\u30ec\u30dd\u30fc\u30c8\u304c\u3001\u8907\u6570\u306e\u81e8\u5e8a\u304a\u3088\u3073\u79d1\u5b66\u9818\u57df\u306e\u5c02\u9580\u5bb6\u306b\u3088\u3063\u3066\u7a4d\u6975\u7684\u306b\u67fb\u8aad\u3055\u308c\u307e\u3059\u3002MTB\u306f\u901a\u5e38\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u30e1\u30f3\u30d0\u30fc\u3067\u69cb\u6210\u3055\u308c\u307e\u3059\u3002\u5229\u7528\u53ef\u80fd\u306a\u6a19\u7684\u6cbb\u7642\u304a\u3088\u3073\u81e8\u5e8a\u8a66\u9a13\u306e\u9078\u629e\u80a2\u3001\u306a\u3089\u3073\u306b\u60a3\u8005\u7279\u6709\u306e\u8981\u56e0\u306b\u7cbe\u901a\u3057\u305f\u816b\u760d\u5185\u79d1\u533b \u3001\u5206\u5b50\u89e3\u6790\u306b\u95a2\u3059\u308b\u5c02\u9580\u77e5\u8b58\u3092\u6301\u3064\u5206\u5b50\u75c5\u7406\u5b66\u8005\u3001\u540c\u5b9a\u3055\u308c\u305f\u4f53\u7d30\u80de\u5909\u7570\u304c\u751f\u6b96\u7d30\u80de\u7cfb\u5217\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u306b\u3064\u3044\u3066\u60c5\u5831\u63d0\u4f9b\u304c\u3067\u304d\u308b\u304c\u3093\u907a\u4f1d\u5b66\u8005\u307e\u305fMTB\u306f\u3001\u30b2\u30ce\u30e0\u30c7\u30fc\u30bf\u3001\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u6280\u8853\u3001\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u9069\u5408\u7642\u6cd5\u306b\u95a2\u3059\u308b\u7406\u89e3\u3092\u6df1\u3081\u308b\u305f\u3081\u306e\u533b\u5e2b\u6559\u80b2\u306b\u3068\u3063\u3066\u3001\u7406\u60f3\u7684\u306a\u30d5\u30a9\u30fc\u30e9\u30e0\u3067\u3082\u3042\u308a\u307e\u3059\u3002NCIS\u3067\u306f\u3001\u6bce\u9031\u3001NCIS Developmental Therapeutics Unit\uff08DTU\uff09\u306b\u3088\u3063\u3066MTB\u304c\u958b\u50ac\u3055\u308c\u3001\u5206\u5b50\u30d7\u30ed\u30d5\u30a1\u30a4\u30ea\u30f3\u30b0\u30c7\u30fc\u30bf\u304c\u30ec\u30d3\u30e5\u30fc\u3055\u308c\u3066\u3044\u307e\u3059\u3002NCIS DTU\u30c1\u30fc\u30e0\u306f\u3001\u816b\u760d\u90e8\u4f4d\u7279\u7570\u7684\u306a\u5c02\u9580\u5bb6\u304a\u3088\u3073\u521d\u671f\u6bb5\u968e\u306e\u85ac\u7269\u958b\u767a\u5c02\u9580\u5bb6\u3067\u69cb\u6210\u3055\u308c\u3066\u3044\u307e\u3059\u3002MTB\u306f\u3001\u5909\u7570\u3068\u81e8\u5e8a\u8a66\u9a13\u306b\u767b\u9332\u3059\u3079\u304d\u60a3\u8005\u306e\u7279\u5b9a\u306b\u5f79\u7acb\u3064\u3060\u3051\u3067\u306a\u304f\u3001\u8a66\u9a13\u304c\u9069\u5207\u3067\u3042\u308b\u3068\u5224\u65ad\u3067\u304d\u306a\u3044\u5834\u5408\u3067\u3082\u3001NGS\u30c7\u30fc\u30bf\u3092\u6d3b\u7528\u3057\u3066\u4ee3\u66ff\u306e\u6a19\u7684\u85ac\u5264\u306e\u9078\u629e\u80a2\u3092\u691c\u8a0e\u3059\u308b\u4e0a\u3067\u6709\u7528\u3067\u3059\u3002MTB\u5185\u3067\u306f\u3001\u5404\u60a3\u8005\u306e\u56fa\u6709\u306e\u7a81\u7136\u5909\u7570\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3092\u57fa\u306b\u6cbb\u7642\u8a08\u753b\u3092\u6c7a\u5b9a\u3057\u307e\u3059\u3002Dr 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\u304c\u3093\u6cbb\u7642\u306b\u304a\u3051\u308b\u6b21\u4e16\u4ee3\u30b7\u30fc\u30b1\u30f3\u30b9\u89e3\u6790\u3001\u5206\u5b50\u816b\u760d\u75c7\u4f8b\u3001\u305d\u3057\u3066\u81e8\u5e8a\u610f\u601d\u6c7a\u5b9a\u652f\u63f4\u30c4\u30fc\u30eb\u306e\u9032\u5316\u3059\u308b\u5f79\u5272\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u306f\u3001\u4ee5\u4e0b\u306e\u4ed6\u306e\u30b1\u30fc\u30b9\u30b9\u30bf\u30c7\u30a3\u3082\u3054\u89a7\u304f\u3060\u3055\u3044\u3002\u00a0<\/em> <\/p>\n \u00a0 <\/p>\n \u53c2\u8003\u6587\u732e:<\/em> <\/p>\n [1]<\/a> Zhao J, et al. \u201cNext generation sequencing based mutation profiling reveals heterogeneity of clinical response and resistance to osimertinib.\u201dLung Cancer. 2020 Mar; vol. 141:114-118.<\/p>\n [2]<\/a> Zhy Y, et al. \u201cDurable complete response to alectinib in a lung adenocarcinoma patient with brain metastases and low-abundance EML4-ALK variant in liquid biopsy: a case report.\u201dFrontiers in Oncology. 2020 Jul; 10:1259. 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Tan\u306f\u6b21\u306e\u3088\u3046\u306b\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002\u300c\u518d\u767a\u30fb\u96e3\u6cbb\u6027\u304c\u3093\u3068\u306f\u5225\u306b\u3001\u80ba\u304c\u3093\u3084\u5375\u5de3\u304c\u3093\u306a\u3069\u3001\u5305\u62ec\u7684\u306a\u30b2\u30ce\u30e0\u30d7\u30ed\u30d5\u30a1\u30a4\u30ea\u30f3\u30b0\u306e\u7d50\u679c\u304c\u6cbb\u7642\u7684\u5c64\u5225\u5316\u306b\u3068\u3063\u3066\u91cd\u8981\u3068\u306a\u308b\u75be\u60a3\u306e\u4e00\u6b21\u6cbb\u7642\u306e\u72b6\u6cc1\u306b\u304a\u3044\u3066\u3001\u00a0NGS\u306e\u91cd\u8981\u6027\u304c\u9ad8\u307e\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u8a8d\u8b58\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u300d\u30a2\u30b8\u30a2\u3067\u306eNGS\u306e\u65e9\u671f\u5c0e\u5165\u8005\u3068\u3057\u3066\u3001NCIS\u306e\u85ac\u7269\u958b\u767a\u30c1\u30fc\u30e0\u306f\u3001\u9069\u683c\u306a\u60a3\u8005\u3078\u7121\u511f\u3067\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u3092\u63d0\u4f9b\u3059\u308b\u305f\u3081\u306b\u3001\u521d\u671f\u6bb5\u968e\u306e\u81e8\u5e8a\u8a66\u9a13\u30e6\u30cb\u30c3\u30c8\u3067\u3042\u308bNCIS Developmental Therapeutics Unit\uff08DTU\uff09\u00a0\u3092\u8a2d\u7acb\u3057\u307e\u3057\u305f\u3002\u3055\u3089\u306bNCIS\u306f2014\u5e74\u306bIntegrated Molecular Profiling of Cancers\uff08IMAC\uff09\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u958b\u59cb\u3057\u3001\u5f53\u521d\u306f50\u907a\u4f1d\u5b50\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30d1\u30cd\u30eb\u3067\u3057\u305f\u304c\u3001\u73fe\u5728\u3067\u306f324\u907a\u4f1d\u5b50\u3092\u5bfe\u8c61\u3068\u3059\u308b\u898f\u6a21\u306b\u6210\u9577\u3057\u3066\u3044\u307e\u3059\u3002 NCIS\u306e\u5206\u5b50\u816b\u760d\u75c7\u4f8b \u591a\u304f\u306eNGS\u7814\u7a76\u304c\u81e8\u5e8a\u7684\u6709\u52b9\u6027\u3092\u793a\u3059\u3053\u3068\u306b\u6210\u529f\u3057\u3066\u3044\u308b\u305f\u3081\u3001\u30b2\u30ce\u30df\u30af\u30b9\u306e\u5c02\u9580\u77e5\u8b58\u3092\u6301\u305f\u306a\u3044\u533b\u5e2b\u3067\u3082\u5206\u5b50\u816b\u760d\u75c7\u4f8b\uff08MTB\uff09\u306b\u53c2\u52a0\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002MTB\u3067\u306f\u3001\u89e3\u91c8\u304c\u56f0\u96e3\u306a\u5834\u5408\u304c\u3042\u308b\u73fe\u5b9f\u4e16\u754c\u306e\u60a3\u8005NGS\u30ec\u30dd\u30fc\u30c8\u304c\u3001\u8907\u6570\u306e\u81e8\u5e8a\u304a\u3088\u3073\u79d1\u5b66\u9818\u57df\u306e\u5c02\u9580\u5bb6\u306b\u3088\u3063\u3066\u7a4d\u6975\u7684\u306b\u67fb\u8aad\u3055\u308c\u307e\u3059\u3002MTB\u306f\u901a\u5e38\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u30e1\u30f3\u30d0\u30fc\u3067\u69cb\u6210\u3055\u308c\u307e\u3059\u3002\u5229\u7528\u53ef\u80fd\u306a\u6a19\u7684\u6cbb\u7642\u304a\u3088\u3073\u81e8\u5e8a\u8a66\u9a13\u306e\u9078\u629e\u80a2\u3001\u306a\u3089\u3073\u306b\u60a3\u8005\u7279\u6709\u306e\u8981\u56e0\u306b\u7cbe\u901a\u3057\u305f\u816b\u760d\u5185\u79d1\u533b \u3001\u5206\u5b50\u89e3\u6790\u306b\u95a2\u3059\u308b\u5c02\u9580\u77e5\u8b58\u3092\u6301\u3064\u5206\u5b50\u75c5\u7406\u5b66\u8005\u3001\u540c\u5b9a\u3055\u308c\u305f\u4f53\u7d30\u80de\u5909\u7570\u304c\u751f\u6b96\u7d30\u80de\u7cfb\u5217\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u306b\u3064\u3044\u3066\u60c5\u5831\u63d0\u4f9b\u304c\u3067\u304d\u308b\u304c\u3093\u907a\u4f1d\u5b66\u8005\u307e\u305fMTB\u306f\u3001\u30b2\u30ce\u30e0\u30c7\u30fc\u30bf\u3001\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u6280\u8853\u3001\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u9069\u5408\u7642\u6cd5\u306b\u95a2\u3059\u308b\u7406\u89e3\u3092\u6df1\u3081\u308b\u305f\u3081\u306e\u533b\u5e2b\u6559\u80b2\u306b\u3068\u3063\u3066\u3001\u7406\u60f3\u7684\u306a\u30d5\u30a9\u30fc\u30e9\u30e0\u3067\u3082\u3042\u308a\u307e\u3059\u3002NCIS\u3067\u306f\u3001\u6bce\u9031\u3001NCIS Developmental Therapeutics 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\n[3]<\/a> Tismberidou, AS, et al. \u201cPersonalized medicine in a phase I clinical trials program: the MD Anderson Cancer Center initiative.\u201dClin Cancer Res. 2012 Nov; 18(22):6373-83.
\n[4]<\/a> Tan DSP, et al. \u201cRecommendations to improve the clinical adoption of NGS-based cancer diagnostics in Singapore.\u201dAsia Pacific Journal of Clinical Oncology. 2020 Apr; Volume 16, Issue 4.<\/div>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"