{"id":149987,"date":"2026-01-27T08:25:31","date_gmt":"2026-01-27T08:25:31","guid":{"rendered":"https:\/\/labinsights.com\/acf_article\/%e3%83%87%e3%82%b8%e3%82%bf%e3%83%ab%e6%8a%95%e4%b8%8e%e3%81%a8%e6%b2%bb%e7%99%82%e8%96%ac%e7%89%a9%e3%83%a2%e3%83%8b%e3%82%bf%e3%83%aa%e3%83%b3%e3%82%b0%e3%81%ae%e6%9c%aa%e6%9d%a5%ef%bc%9a%e7%ac%ac23\/"},"modified":"2026-03-15T07:05:29","modified_gmt":"2026-03-15T07:05:29","slug":"digital-dosing-and-the-future-of-therapeutic-drug-monitoring-insights-from-the-23rd-iatdmct-congress","status":"publish","type":"acf_article","link":"https:\/\/labinsights.com\/ja\/event-coverage\/conferences\/digital-dosing-and-the-future-of-therapeutic-drug-monitoring-insights-from-the-23rd-iatdmct-congress\/","title":{"rendered":"\u30c7\u30b8\u30bf\u30eb\u6295\u4e0e\u3068\u6cbb\u7642\u85ac\u7269\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u306e\u672a\u6765\uff1a\u7b2c23\u56deIATDMCT\u4f1a\u8b70\u304b\u3089\u306e\u77e5\u898b"},"content":{"rendered":"<p><span style=\"font-weight: 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style=\"font-weight: 400;\">\u3053\u308c\u3089\u306e\u5c02\u9580\u5bb6\u306f\u5171\u306b\u3001\u6b21\u4e16\u4ee3\u306e\u8a3a\u65ad\u4fa1\u5024\u3068\u60a3\u8005\u30b1\u30a2\u3092\u5b9a\u7fa9\u3059\u308b\u4e0d\u53ef\u6b20\u306a\u30c7\u30b8\u30bf\u30eb\u306e\u67f1\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3059\u3002<\/span><\/p>\n<h2 style=\"font-family: Inter !important; font-weight: 500 !important; font-size: 28px !important; line-height: 36px !important; letter-spacing: 0px !important;\">\u57fa\u790e\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u3068\u3057\u3066\u306e\u30e2\u30c7\u30eb\u60c5\u5831\u5316\u7cbe\u5bc6\u6295\u4e0e(MIPD)<\/h2>\n<p><span style=\"font-weight: 400;\">2\u3064\u306e\u6a5f\u95a2\u304c\u540c\u4e00\u3067\u306f\u306a\u304f\u3001\u500b\u5225\u5316\u306e\u81e8\u5e8a\u7684\u5fc5\u8981\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u300c\u4eba\u9593\u306e\u4f53\u306f\u5747\u4e00\u306a\u6c34\u69fd\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u30b7\u30f3\u30ac\u30dd\u30fc\u30eb\u7dcf\u5408\u75c5\u9662\u306eAndrea Kwa\u6559\u6388\u306f\u3001\u57fa\u8abf\u8b1b\u6f14\u306e\u4e2d\u3067\u3001\u85ac\u5264\u306e\u5206\u5e03\u306f\u7570\u306a\u308b\u3068\u5f37\u8abf\u3057\u307e\u3057\u305f\u3002\u7cbe\u5bc6\u6295\u4e0e\u306e\u76ee\u6a19\u306f\u3001\u500b\u3005\u306e\u60a3\u8005\u306b\u304a\u3044\u3066\u5fc5\u8981\u3068\u3055\u308c\u308b\u6709\u52b9\u6027\u3092\u6700\u5c0f\u9650\u306e\u6bd2\u6027\u3067\u63d0\u4f9b\u3059\u308b\u6700\u3082\u6700\u9069\u306a\u6295\u4e0e\u30ec\u30b8\u30e1\u30f3\u3092\u7279\u5b9a\u3059\u308b\u3053\u3068\u3067\u3059[1]\u3002MIPD\u306f\u3001\u3053\u306e\u76ee\u6a19\u3092\u9054\u6210\u3059\u308b\u305f\u3081\u306e\u4e0d\u53ef\u6b20\u306a\u5b9a\u91cf\u7684\u67a0\u7d44\u307f\u3068\u3057\u3066\u6d6e\u4e0a\u3057\u3066\u3044\u307e\u3059\u3002\u305d\u308c\u306f\u3001\u9ad8\u5ea6\u306a\u85ac\u7269\u52d5\u614b\/\u85ac\u529b\u5b66(PK\/PD)\u30e2\u30c7\u30eb\u3092\u5229\u7528\u3057\u3066\u3001\u85ac\u7269\u7642\u6cd5\u5168\u4f53\u3092\u901a\u3057\u3066\u8907\u6570\u306e\u5de5\u7a0b\u3067\u7528\u91cf\u3092\u500b\u5225\u5316\u3059\u308b\u3001\u60a3\u8005\u56fa\u6709\u306e\u60c5\u5831\u53ca\u3073\u81e8\u5e8a\u89b3\u5bdf\u3092\u7d71\u5408\u53ca\u3073\u63a1\u7528\u3057\u307e\u3059\u3002<\/span> <span style=\"font-weight: 400;\">\u3053\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u3001\u30b5\u30a4\u30af\u30eb\u3092\u4e88\u6e2c\u3057\u3001\u78ba\u8a8d\u3057\u3001\u5b66\u7fd2\u3057\u3001\u9069\u7528\u3059\u308b\u3082\u306e\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\uff1a<\/span><\/p>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u4e88\u6e2c\uff08\u4e00\u6b21\u7528\u91cf\u9069\u5408\uff09:<\/b><span style=\"font-weight: 400;\"> \u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u60a3\u8005\u30c7\u30fc\u30bf\uff08\u4f8b\u3048\u3070\u3001\u4f53\u91cd\u3001\u5e74\u9f62\u3001\u907a\u4f1d\u5b50\u69cb\u6210\u3001\u53ca\u3073\u81d3\u5668\u6a5f\u80fd\uff09\u306f\u3001\u30e2\u30c7\u30eb\u3092\u77e5\u3089\u305b\u3001\u521d\u671f\u958b\u59cb\u7528\u91cf\u3092\u8a2d\u8a08\u3059\u308b\u305f\u3081\u306b\u5171\u5909\u91cf\u3068\u3057\u3066\u53ce\u96c6\u3055\u308c\u307e\u3059\u3002Moes\u535a\u58eb\u306f\u3001\u3053\u306e\u91cd\u8981\u306a\u6700\u521d\u306e\u30b9\u30c6\u30c3\u30d7\u3092\u300c\u524d\u7dda\u91cf\u9069\u5408\u300d\u3068\u547c\u3073\u307e\u3057\u305f[2]\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u78ba\u8a8d\u304a\u3088\u3073\u6539\u826f\uff1a<\/b><span style=\"font-weight: 400;\"> \u2013 \u60a3\u8005\u9593\u306e\u9ad8\u3044\u5909\u52d5\u6027\u3092\u5236\u5fa1\u3059\u308b\u305f\u3081\u306b\u3001\u89b3\u5bdf\u3055\u308c\u305f\u30c7\u30fc\u30bf\uff08\u4f8b\u3048\u3070\u3001\u85ac\u7269\u6fc3\u5ea6\u6e2c\u5b9a\u304a\u3088\u3073PD\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\uff09\u304c\u30d9\u30a4\u30b8\u30a2\u30f3\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u3068\u3057\u3066\u4f7f\u7528\u3055\u308c\u3066\u30e2\u30c7\u30eb\u3092\u66f4\u65b0\u3057\u3001\u60a3\u8005\u306e\u5b9f\u969b\u306e\u85ac\u7269\u53d6\u308a\u6271\u3044\u304a\u3088\u3073\u8868\u73fe\u578b\u3092\u53cd\u6620\u3059\u308b\u3053\u3068\u3092\u53ef\u80fd\u306b\u3057\u307e\u3059\u3002[2] 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400;\">MIPD\u306e\u52b9\u679c\u7684\u306a\u4f7f\u7528\u3092\u53ef\u80fd\u306b\u3059\u308b\u91cd\u8981\u306a\u8981\u56e0\u306f\u3001\u3057\u305f\u304c\u3063\u3066\u3001\u5805\u7262\u306a\u81e8\u5e8a\u30a4\u30f3\u30d5\u30e9\u30b9\u30c8\u30e9\u30af\u30c1\u30e3\u3001\u4fe1\u983c\u6027\u306e\u9ad8\u3044\u5b9f\u9a13\u5ba4\u30a2\u30c3\u30bb\u30a4(\u4f8b\u3048\u3070\u3001\u8907\u6570\u306e\u6297\u4f53\u3092\u591a\u91cd\u5316\u3059\u308b\u305f\u3081\u306e\u6db2<\/span><span style=\"font-weight: 400;\">\u4f53\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30d5\u30a3\u30fc \u2013 \u8cea\u91cf\u5206\u6790)\u3001\u4e26\u3073\u306b\u6975\u3081\u3066\u91cd\u8981\u306a\u3053\u3068\u306b\u3001\u6295\u4e0e\u30c4\u30fc\u30eb\u3078\u306eEHR\u53ca\u3073\u5b9f\u9a13\u5ba4\u60c5\u5831\u30b7\u30b9\u30c6\u30e0(LIS)\u306e\u76f4\u63a5\u7d71\u5408\u3092\u5fc5\u8981\u3068\u3057\u307e\u3059[1]\u3002\u305d\u306e\u4e00\u4f8b\u304c\u3001\u30b7\u30f3\u30b7\u30ca\u30c6\u30a3\u5c0f\u5150\u75c5\u9662\u533b\u7642\u30bb\u30f3\u30bf\u30fc(CCHMC)\u306e\u6c34\u91ce\u533b\u5e2b\u3068\u5f7c\u306e\u30c1\u30fc\u30e0\u306b\u3088\u3063\u3066\u958b\u767a\u3055\u308c\u305f\u624b\u8853\u7528\u6295\u4e0e\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u3067\u3042\u308bRoadMAB\u3068\u3044\u3046\u30d7\u30ed\u30b0\u30e9\u30e0\u3067\u3059[3,4]\u3002<\/span> <span style=\"font-weight: 400;\">\u3053\u306e\u30c4\u30fc\u30eb\u306f\u3001\u5206\u6790\u306b\u5fc5\u8981\u306a\u60a3\u8005\u30c7\u30fc\u30bf\u3092\u81ea\u52d5\u7684\u306b\u4fee\u6b63\u3057\u3001\u30c7\u30fc\u30bf\u3001\u8a3a\u65ad\u3001\u6c7a\u5b9a\u306e\u9593\u306e\u30c7\u30b8\u30bf\u30eb\u30eb\u30fc\u30d7\u3092\u52b9\u679c\u7684\u306b\u9589\u3058\u308b\u305f\u3081\u306bEHR\u306b\u7d71\u5408\u3055\u308c\u308b\u3088\u3046\u306b\u7279\u306b\u8a2d\u8a08\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u00a0\u00a0<\/span><\/p>\n<h2 style=\"font-family: Inter !important; font-weight: 500 !important; font-size: 28px !important; line-height: 36px !important; letter-spacing: 0px !important;\">\u30ea\u30a2\u30eb\u30ef\u30fc\u30eb\u30c9\u30c7\u30fc\u30bf(RWD)\u3068\u30d3\u30c3\u30b0\u30c7\u30fc\u30bf\u5206\u6790\u306e\u529b<\/h2>\n<p><span style=\"font-weight: 400;\">MIPD\u306f\u3001\u500b\u5225\u5316\u3055\u308c\u305f\u6295\u4e0e\u306e\u305f\u3081\u306e\u91cd\u8981\u306a\u5b9a\u91cf\u7684\u67a0\u7d44\u307f\u3092\u63d0\u4f9b\u3059\u308b\u304c\u3001\u3053\u306e\u30c7\u30b8\u30bf\u30eb\u30a2\u30d7\u30ed\u30fc\u30c1\u306e\u771f\u306e\u529b\u306f\u3001\u305d\u306e\u4e88\u6e2c\u30e2\u30c7\u30eb\u304c\u73fe\u5b9f\u4e16\u754c\u306e\u8a3c\u62e0\u306b\u3088\u3063\u3066\u7d99\u7d9a\u7684\u306b\u6539\u826f\u3055\u308c\u308b\u3068\u304d\u306b\u5b9f\u73fe\u3055\u308c\u307e\u3059\u3002\u305d\u3053\u3067RWD\u3068\u30d3\u30c3\u30b0\u30c7\u30fc\u30bf\u89e3\u6790\u304cTDM\u3068\u81e8\u5e8a\u6bd2\u7269\u5b66\u306e\u4e21\u65b9\u3092\u9032\u6b69\u3055\u305b\u308b\u305f\u3081\u306b\u4e0d\u53ef\u6b20\u306a\u30c4\u30fc\u30eb\u3068\u306a\u308a\u307e\u3059[5]\u3002\u00a0<\/span> <span style=\"font-weight: 400;\">RWD\u306e\u5f37\u307f\u306f\u3001\u5e45\u5e83\u3044\u30b3\u30ec\u30af\u30b7\u30e7\u30f3\u306b\u3042\u308a\u307e\u3059\u3002RWD\u306f\u3001\u81ea\u767a\u5831\u544a\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3001\u8acb\u6c42\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3001\u53ca\u3073EHR\u304b\u3089\u60c5\u5831\u6e90\u3092\u5f97\u3066\u304a\u308a\u3001\u6709\u5bb3\u4e8b\u8c61\u306e\u691c\u51fa\u53ca\u3073\u73fe\u5728\u306e\u81e8\u5e8a\u8a3a\u7642\u30d1\u30bf\u30fc\u30f3\u306e\u8a55\u4fa1\u306b\u4e0d\u53ef\u6b20\u306a\u88dc\u5b8c\u7684\u306a\u6d1e\u5bdf\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059[6]\u3002\u3053\u306e\u81a8\u5927\u3067\u8907\u96d1\u306a\u30c7\u30fc\u30bf\u30bb\u30c3\u30c8\u306f\u3001\u4eee\u8aac\u306e\u751f\u6210\u306b\u4e0d\u53ef\u6b20\u3067\u3042\u308b\u3002\u5927\u898f\u6a21\u306a\u89b3\u5bdf\u7684RWD\u30bb\u30c3\u30c8\uff08Dr Legg\u304c\u5f15\u7528\u3057\u3066\u3044\u308b\u03b2 \u2013 \u30e9\u30af\u30bf\u30e0TDM\u306eBLUeY\u30ec\u30b8\u30b9\u30c8\u30ea[5]\u306a\u3069\uff09\u306b\u3088\u308a\u3001ML\u306f\u3001\u7a00\u306a\u7d50\u679c\u53c8\u306f\u8907\u96d1\u306a\u60a3\u8005\u306e\u5909\u52d5\u6027\u306e\u305f\u3081\u306b\u3001\u3088\u308a\u5c0f\u898f\u6a21\u306a\u5f93\u6765\u306e\u7814\u7a76\u3067\u306f\u3057\u3070\u3057\u3070\u898b\u9003\u3055\u308c\u308b\u65e9\u671f\u306e\u4eee\u8aac\u751f\u6210\u30b7\u30b0\u30ca\u30eb\u3092\u540c\u5b9a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059[8]\u3002\u00a0<\/span> <span style=\"font-weight: 400;\">\u3088\u308a\u91cd\u8981\u306a\u3053\u3068\u306f\u3001\u3053\u306e\u30c7\u30fc\u30bf\u304c\u5b9f\u8a3c\u3067\u304d\u308b\u81e8\u5e8a\u7684\u5f71\u97ff\u306b\u76f4\u63a5\u7d50\u3073\u3064\u304f\u3053\u3068\u3067\u3059\u3002\u4f8b\u3048\u3070\u3001\u8acb\u6c42\u66f8\u30c7\u30fc\u30bf\u306e\u5206\u6790\u306b\u3088\u308a\u3001\u4e00\u8cab\u3057\u305f\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7TDM\u304c\u85ac\u7269\u8a98\u767a\u6027\u6bd2\u6027\u306e\u767a\u751f\u7387\u3092\u5287\u7684\u306b\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u304a\u308a\u3001\u3042\u308b\u7814\u7a76\u3067\u306f\u3001\u3053\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u3001\u5c71\u7530\u533b\u5e2b\u304c\u5171\u6709\u3059\u308b\u3088\u3046\u306b\u3001\u30d0\u30f3\u30b3\u30de\u30a4\u30b7\u30f3\u8a98\u767a\u6027\u814e\u6bd2\u6027\u306e\u767a\u751f\u7387\u309260.9%\u304b\u30899.9%\u306b\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u306b\u7559\u610f\u3057\u3066\u3044\u307e\u3059[6]\u3002\u00a0<\/span><\/p>\n<h2 style=\"font-family: Inter !important; font-weight: 500 !important; font-size: 28px !important; line-height: 36px !important; letter-spacing: 0px !important;\">\u6b21\u4e16\u4ee3\u610f\u601d\u6c7a\u5b9a\u652f\u63f4\u306e\u305f\u3081\u306eAI\u3068\u6a5f\u68b0\u5b66\u7fd2(ML)<\/h2>\n<p><span style=\"font-weight: 400;\">RWD\u3092\u4f7f\u7528\u3057\u3066\u4eee\u8aac\u3092\u751f\u6210\u3057\u3001\u5b9f\u8df5\u30d1\u30bf\u30fc\u30f3\u3092\u691c\u8a3c\u3059\u308b\u80fd\u529b\u306f\u3001\u305d\u306e\u3088\u3046\u306a\u5927\u898f\u6a21\u3067\u8907\u96d1\u306a\u30c7\u30fc\u30bf\u30bb\u30c3\u30c8\u3092\u51e6\u7406\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u9ad8\u5ea6\u306a\u5206\u6790\u30c4\u30fc\u30eb\u306b\u5bfe\u3059\u308b\u91cd\u8981\u306a\u9700\u8981\u3092\u751f\u307f\u51fa\u3057\u307e\u3059\u3002\u8a3a\u65ad\u30e9\u30dc\u3068\u81e8\u5e8a\u30c1\u30fc\u30e0\u304c\u3001AI\u3068ML\u306e\u9ad8\u5ea6\u306a\u8a08\u7b97\u80fd\u529b\u3092\u901a\u3058\u3066\u3001\u3053\u306e\u5927\u91cf\u306e\u30c7\u30fc\u30bf\u3092\u4e88\u6e2c\u7684\u3067\u5b9f\u7528\u7684\u306a\u3001\u500b\u5225\u5316\u3055\u308c\u305f\u6295\u4e0e\u6d1e\u5bdf\u306b\u5909\u63db\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/span><\/p>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u52d5\u7684\u30e2\u30c7\u30ea\u30f3\u30b0\uff1a<\/b><span style=\"font-weight: 400;\"> AI\u306f\u3001Dr Legg\u306b\u3088\u3063\u3066\u5f37\u8abf\u3055\u308c\u308b\u3088\u3046\u306b\u3001\u7d4c\u6642\u7684\u306b\u60a3\u8005\u306e\u5909\u5316\u3059\u308b\u81e8\u5e8a\u30d1\u30e9\u30e1\u30fc\u30bf\u306b\u8abf\u6574\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3001\u3088\u308a\u8907\u96d1\u3067\u52d5\u7684\u306a\u96c6\u56e3PK(PopPK)\u30e2\u30c7\u30eb\u3092\u958b\u767a\u3059\u308b\u305f\u3081\u306b\u3001\u5fc5\u8981\u306a\u5927\u304d\u306a\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u304a\u3088\u3073\u4ea4\u7d61\u5909\u6570\u3092\u51e6\u7406\u3059\u308b\u4e0a\u3067\u6975\u3081\u3066\u91cd\u8981\u3067\u3059[8]\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u30cf\u30a4\u30d6\u30ea\u30c3\u30c9\u30e2\u30c7\u30eb<\/b><span style=\"font-weight: 400;\">\uff1a\u6c34\u91ce\u535a\u58eb\u306f\u307e\u305f\u3001\u6700\u3082\u6709\u671b\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u3001\u30b5\u30a4\u30ed\u6280\u8853\u3092\u8d85\u3048\u3066\u79fb\u52d5\u3059\u308b\u3053\u3068\u3092\u5f37\u8abf\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u5f93\u6765\u306e\u30d9\u30a4\u30ba\u63a8\u5b9a\u306e\u81e8\u5e8a\u7684\u59a5\u5f53\u6027\u3092ML\u3068\u7d44\u307f\u5408\u308f\u305b\u3066\uff08\u4f8b\u3048\u3070\u3001XGBoost\u30e2\u30c7\u30eb\u3092\u4f7f\u7528\u3057\u3066\uff09\u3001\u4e88\u6e2c\u8aa4\u5dee\u3092\u88dc\u6b63\u3059\u308b\u3053\u3068\u3092\u542b\u307f\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u5f93\u6765\u306ePopPK\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u4e00\u8cab\u3057\u3066\u4e0a\u56de\u308b\u30ed\u30d0\u30b9\u30c8\u306a\u30cf\u30a4\u30d6\u30ea\u30c3\u30c9\u30e2\u30c7\u30eb\u304c\u5f97\u3089\u308c\u307e\u3059[3]\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u81ea\u52d5\u5316\u3068AI\u306e\u4e88\u6e2c\uff1a\u5c06\u6765\u306e\u30b7\u30b9\u30c6\u30e0\u3067\u306f<\/b><span style=\"font-weight: 400;\">\u3001\u5f37\u5316\u5b66\u7fd2\u3092\u4f7f\u7528\u3057\u3066\u3001\u60a3\u8005\u30c7\u30fc\u30bf\u3092\u81ea\u52d5\u7684\u306b\u53ce\u96c6\u3057\u3001\u6cbb\u7642\u30aa\u30d7\u30b7\u30e7\u30f3\u3092\u8a55\u4fa1\u3057\u3001\u6295\u4e0e\u30ec\u30b8\u30e1\u30f3\u3068\u9593\u9694\u3092\u63d0\u6848\u3067\u304d\u308bAI\u30a8\u30fc\u30b8\u30a7\u30f3\u30c8\u3092\u4f5c\u6210\u3057\u3066\u3044\u307e\u3059\u3002\u6c34\u91ce\u535a\u58eb\u306f\u307e\u305f\u3001\u3053\u306e\u9032\u6b69\u304c\u6295\u85ac\u30d7\u30ed\u30bb\u30b9\u5168\u4f53\u3092\u5408\u7406\u5316\u3057\u3001\u4eba\u9593\u306e\u610f\u601d\u6c7a\u5b9a\u3092\u5411\u4e0a\u3055\u305b\u308b\u3068\u5f37\u8abf\u3057\u3066\u3044\u307e\u3059[3]\u3002<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2 style=\"font-family: Inter !important; font-weight: 500 !important; font-size: 28px !important; line-height: 36px !important; letter-spacing: 0px !important;\">\u8a3a\u65ad\u7684\u30ea\u30fc\u30c0\u30fc\u30b7\u30c3\u30d7\u306e\u305f\u3081\u306e\u6226\u7565\u7684\u4fa1\u5024\u3068\u6295\u8cc7\u53ce\u76ca\u7387(ROI)<\/h2>\n<p><span style=\"font-weight: 400;\">\u5168\u4f53\u3068\u3057\u3066\u3001MIPD\u30d5\u30ec\u30fc\u30e0\u30ef\u30fc\u30af\u3001RWD\u3001\u4e88\u6e2cAI\u306e\u7d71\u5408\u306f\u3001\u5b66\u8853\u7684\u306a\u30b3\u30f3\u30bb\u30d7\u30c8\u4ee5\u4e0a\u306e\u3082\u306e\u3067\u3042\u308a\u3001\u8a3a\u65ad\u306e\u4fa1\u5024\u63d0\u6848\u306b\u304a\u3051\u308b\u6839\u672c\u7684\u306a\u5909\u5316\u3092\u8868\u3057\u3066\u3044\u307e\u3059\u3002\u691c\u67fb\u5ba4\u3084\u75c5\u9662\u306e\u30ea\u30fc\u30c0\u30fc\u30b7\u30c3\u30d7\u306b\u3068\u3063\u3066\u3001\u3053\u306e\u53ce\u675f\u306f\u3001\u60a3\u8005\u306e\u30dc\u30c8\u30e0\u30e9\u30a4\u30f3\u3068\u7d44\u7e54\u306e\u30dc\u30c8\u30e0\u30e9\u30a4\u30f3\u306e\u4e21\u65b9\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u5b9a\u91cf\u5316\u53ef\u80fd\u306a\u5229\u76ca\u306b\u76f4\u63a5\u5909\u63db\u3055\u308c\u307e\u3059\u3002<\/span><\/p>\n<h3 style=\"font-family: Inter !important; font-weight: 500 !important; font-size: 24px !important; line-height: 32px !important; letter-spacing: 0px !important;\">A)\u60a3\u8005\u306e\u5b89\u5168\u6027\u3068\u81e8\u5e8a<\/h3>\n<p><span style=\"font-weight: 400;\">\u8ee2\u5e30\u306e\u5411\u4e0a\u30c7\u30b8\u30bf\u30eb\u5909\u9769\u306e\u4e3b\u306a\u5229\u70b9\u306f\u3001\u8a3a\u65ad\u30b5\u30fc\u30d3\u30b9\u3092\u53d7\u52d5\u7684\u306a\u30ec\u30dd\u30fc\u30c8\u304b\u3089\u7a4d\u6975\u7684\u306a\u500b\u5225\u5316\u3055\u308c\u305f\u30ac\u30a4\u30c0\u30f3\u30b9\u3078\u3068\u683c\u4e0a\u3052\u3057\u3001\u3088\u308a\u826f\u3044\u60a3\u8005\u30b1\u30a2\u306b\u3064\u306a\u304c\u308b\u3053\u3068\u3067\u3059\u3002<\/span><\/p>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u7cbe\u5ea6\u3068\u7cbe\u5ea6\uff1a<\/b><span style=\"font-weight: 400;\"> AI\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u306f\u3001\u4ee5\u524d\u306f\u9054\u6210\u3067\u304d\u306a\u304b\u3063\u305f\u30ec\u30d9\u30eb\u306e\u4e88\u6e2c\u80fd\u529b\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001AI\u30c4\u30fc\u30eb\u306f\u3001\u30ef\u30eb\u30d5\u30a1\u30ea\u30f3\u306e5\u65e5\u76ee\u306e\u56fd\u969b\u6a19\u6e96\u5316\u6bd4(INR)\u306a\u3069\u306e\u91cd\u8981\u306a\u81e8\u5e8a\u5024\u3092\u3001\u30d2\u30c8\u306e\u5c02\u9580\u5bb6\u3068\u4e00\u81f4\u3059\u308b\u304b\u3001\u307e\u305f\u306f\u308f\u305a\u304b\u306b\u512a\u308c\u305f\u7cbe\u5ea6\u3067\u4e88\u6e2c\u3059\u308b\u80fd\u529b\u3092\u5b9f\u8a3c\u3057\u3066\u3044\u307e\u3059[8]\u3002\u3053\u306e\u4e88\u6e2c\u529b\u306b\u3088\u308a\u3001\u6700\u9069\u306a\u6cbb\u7642\u306b\u304a\u3051\u308b\u5371\u967a\u306a\u9045\u5ef6\u304c\u6700\u5c0f\u9650\u306b\u6291\u3048\u3089\u308c\u307e\u3059\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u7a4d\u6975\u7684\u306a\u4ecb\u5165\uff1a\u4e88\u6e2c\u30e2\u30c7\u30eb\u3068\u81e8\u5e8a\u30ef\u30fc\u30af\u30d5\u30ed\u30fc\u3092\u7d50\u3073\u4ed8\u3051\u308b\u3053\u3068\u306b\u3088\u308a<\/b><span style=\"font-weight: 400;\">\u3001\u30c7\u30b8\u30bf\u30eb\u610f\u601d\u6c7a\u5b9a\u652f\u63f4\u30c0\u30c3\u30b7\u30e5\u30dc\u30fc\u30c9\u306b\u3088\u308a\u3001\u81e8\u5e8a\u533b\u306fPK\u306b\u57fa\u3065\u304f\u5373\u6642\u306e\u7528\u91cf\u63a8\u5968\u3092\u53d7\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u6c34\u91ce\u535a\u58eb\u306b\u3088\u308b\u3068\u3001\u3053\u308c\u306b\u3088\u308a\u7a4d\u6975\u7684\u306a\u4ecb\u5165\u304c\u5bb9\u6613\u306b\u306a\u308a\u3001\u60a3\u8005\u304c\u6cbb\u7642\u76ee\u6a19\u3092\u3088\u308a\u65e9\u304f\u9054\u6210\u304a\u3088\u3073\u7dad\u6301\u3059\u308b\u3053\u3068\u3067\u3001\u5408\u4f75\u75c7\u306e\u767a\u751f\u7387\u3068\u5165\u9662\u671f\u9593\u304c\u6e1b\u5c11\u3057\u3001\u3088\u308a\u826f\u3044\u6cbb\u7642\u8ee2\u5e30\u304c\u30b5\u30dd\u30fc\u30c8\u3055\u308c\u307e\u3059[3]\u3002\u00a0<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h3 style=\"font-family: Inter !important; font-weight: 500 !important; font-size: 24px !important; line-height: 32px !important; letter-spacing: 0px !important;\">B)\u904b\u7528\u52b9\u7387\u3068\u8ca1\u52d9\u6bd2\u6027\u306e\u4f4e<\/h3>\n<p><span style=\"font-weight: 400;\">\u6e1b\u30c7\u30b8\u30bf\u30ebTDM\u306f\u3001\u7279\u306b\u9ad8\u4fa1\u306a\u7279\u6b8a\u85ac\u306b\u95a2\u3059\u308b\u30b3\u30b9\u30c8\u7ba1\u7406\u306e\u5f37\u529b\u306a\u624b\u6bb5\u3068\u3057\u3066\u6a5f\u80fd\u3057\u3001\u85ac\u7269\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u3092\u5177\u4f53\u7684\u306a\u8ca1\u52d9\u53ce\u76ca\u306e\u6e90\u306b\u3057\u307e\u3059\u3002<\/span><\/p>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u30b3\u30b9\u30c8\u306e\u6291\u5236\uff1a<\/b><span style=\"font-weight: 400;\">\u300c\u6700\u9069\u5316\u3055\u308c\u305f\u6295\u85ac\u300d\u306f\u3001\u85ac\u7269\u5ec3\u68c4\u7269\u3068\u66dd\u9732\u3092\u6700\u5c0f\u9650\u306b\u6291\u3048\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u9ad8\u4fa1\u306a\u6cbb\u7642\u306e\u9ad8\u30b3\u30b9\u30c8\u306b\u76f4\u63a5\u5bfe\u51e6\u3057\u307e\u3059\u3002\u5404\u7528\u91cf\u3092\u3067\u304d\u308b\u9650\u308a\u6b63\u78ba\u306b\u3059\u308b\u3053\u3068\u3067\u3001\u75c5\u9662\u306f\u5148\u9032\u6cbb\u7642\u306b\u4f34\u3046\u7d4c\u6e08\u7684\u6bd2\u6027\u306e\u5897\u5927\u3059\u308b\u8ab2\u984c\u3092\u5927\u5e45\u306b\u8efd\u6e1b\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059[2]\u3002\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u5b9a\u91cf\u5316\u53ef\u80fd\u306aROI:<\/b><span style=\"font-weight: 400;\"> PK\/PD\u30e2\u30c7\u30eb\u304a\u3088\u3073<\/span><i><span style=\"font-weight: 400;\">in silico<\/span><\/i><span style=\"font-weight: 400;\"> dose adjustment\u3092\u6226\u7565\u7684\u306b\u4f7f\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u5927\u5e45\u304b\u3064\u6e2c\u5b9a\u53ef\u80fd\u306a\u30b3\u30b9\u30c8\u524a\u6e1b\u304c\u9054\u6210\u3055\u308c\u307e\u3057\u305f\uff1a<\/span>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><b>\u85ac\u7269\u5ec3\u68c4\u7269\u306e\u524a\u6e1b\uff1a<\/b><span style=\"font-weight: 400;\"> ADC\u306e\u7528\u91cf\u8abf\u6574\u306b\u304a\u3044\u3066\u3001\u85ac\u5264\u30d0\u30a4\u30a2\u30eb\u5168\u4f53\u306e\u307f\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u3092\u76ee\u6307\u3059\u6226\u7565\u306b\u3088\u308a\u3001\u85ac\u5264\u8cbb\u304c\u63a8\u5b9a25%\u524a\u6e1b\u3055\u308c\u307e\u3057\u305f[2]\u3002\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><b>\u5ef6\u9577\u3055\u308c\u305f\u9593\u9694\uff1a<\/b><span style=\"font-weight: 400;\"> Moes\u535a\u58eb\u306e\u540c\u3058\u767a\u8868\u3067\u306f\u3001\u30e2\u30c7\u30eb\u306b\u57fa\u3065\u3044\u305f\u7528\u91cf\u6700\u9069\u5316\u306f\u307e\u305f\u3001\u60a3\u8005\u306e\u5229\u4fbf\u6027\u3092\u5411\u4e0a\u3055\u305b\u3001\u540c\u6642\u306b\u30b3\u30b9\u30c8\u3092\u524a\u6e1b\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u76ae\u4e0b\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\uff08\u4f8b\u3048\u3070\u3001\u30cb\u30dc\u30eb\u30de\u30d6\uff09\u306e\u305f\u3081\u306e\u4f53\u91cd\u4f9d\u5b58\u7684\u6295\u85ac\u9593\u9694\u3092\u958b\u767a\u3059\u308b\u3053\u3068\u306f\u3001\u53b3\u683c\u306a\u81e8\u5e8a\u6709\u52b9\u6027\u57fa\u6e96\u3092\u7dad\u6301\u3057\u306a\u304c\u3089\u3001\u5e74\u9593\u85ac\u7269\u8cbb\u7528\u306e30%\u8d85\u3092\u7bc0\u7d04\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059[2]\u3002<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h3 style=\"font-family: Inter !important; font-weight: 500 !important; font-size: 24px !important; line-height: 32px !important; letter-spacing: 0px !important;\">C)\u9023\u7d9a<\/h3>\n<p><span style=\"font-weight: 400;\">\u8a3a\u65ad\u3092\u4fc3\u9032\u3059\u308b\u30c7\u30b8\u30bf\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a9\u30fc\u30e1\u30fc\u30b7\u30e7\u30f3\u306f\u3001\u9023\u7d9a\u30b1\u30a2\u30b7\u30b9\u30c6\u30e0\u5185\u306b\u304a\u3051\u308b\u81e8\u5e8a\u691c\u67fb\u5ba4\u306e\u4f4d\u7f6e\u3092\u6839\u672c\u7684\u306b\u5909\u3048\u307e\u3059\u3002\u3082\u306f\u3084\u5358\u306a\u308b\u30b5\u30fc\u30d3\u30b9\u30d7\u30ed\u30d0\u30a4\u30c0\u30fc\u3067\u306f\u306a\u304f\u3001\u6cbb\u7642\u85ac\u306b\u304a\u3051\u308b\u6226\u7565\u7684\u30d1\u30fc\u30c8\u30ca\u30fc\u3067\u3059\u3002<\/span><\/p>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>EHR\u3068\u306e\u7d71\u5408\uff1a<\/b><span style=\"font-weight: 400;\"> MIPD\u3068ML\u3092EHR\u306b\u76f4\u63a5\u7d71\u5408\u3059\u308bRoadMAB\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u306a\u3069\u306e\u30c4\u30fc\u30eb\u306e\u958b\u767a\u306b\u3088\u308a\u3001\u5fc5\u8981\u306a\u60a3\u8005\u30c7\u30fc\u30bf\u306e\u88dc\u6b63\u304c\u81ea\u52d5\u5316\u3055\u308c\u3001\u81e8\u5e8a\u533b\u306e\u89e3\u6790\u304c\u7c21\u7d20\u5316\u3055\u308c\u307e\u3059[3,4]\u3002\u3053\u306e\u30a4\u30ce\u30d9\u30fc\u30b7\u30e7\u30f3\u306b\u3088\u308a\u3001\u8a3a\u65ad\u4fa1\u5024\u63d0\u6848\u304c\u9759\u7684\u306a\u691c\u67fb\u5ba4\u7d50\u679c\u304b\u3089\u6700\u7d42\u7684\u306a\u5b9f\u884c\u53ef\u80fd\u306a\u6cbb\u7642\u4e0a\u306e\u63a8\u5968\u4e8b\u9805\u306b\u79fb\u884c\u3057\u307e\u3059\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u65b0\u3057\u3044\u30a2\u30c3\u30bb\u30a4\u3068\u591a\u91cd\u5316\uff1a<\/b><span style=\"font-weight: 400;\">Moes\u535a\u58eb\u306b\u3088\u3063\u3066\u6307\u6458\u3055\u308c\u3066\u3044\u308bLCMS\u306a\u3069\u306e\u6b21\u4e16\u4ee3\u30a2\u30c3\u30bb\u30a4\u3078\u306e\u6226\u7565\u7684\u6295\u8cc7\u306b\u3088\u308a\u3001\u5358\u4e00\u306e\u60a3\u8005\u8a66\u6599\u4e2d\u306e\u8907\u6570\u306e\u85ac\u7269\u6fc3\u5ea6\u307e\u305f\u306f\u6297\u4f53\u306e\u540c\u6642\u6e2c\u5b9a\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059[2]\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u30e9\u30dc\u306e\u30b5\u30fc\u30d3\u30b9\u30dd\u30fc\u30c8\u30d5\u30a9\u30ea\u30aa\u304c\u5f37\u5316\u3055\u308c\u3001\u52b9\u7387\u304c\u5411\u4e0a\u3057\u3001\u751f\u7269\u5b66\u7684\u88fd\u5264\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u306e\u8907\u96d1\u306a\u30cb\u30fc\u30ba\u3092\u30b5\u30dd\u30fc\u30c8\u3057\u307e\u3059\u3002\u00a0<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">\u3053\u308c\u3089\u306e\u5b9f\u73fe\u3055\u308c\u305f\u52b9\u7387\u306f\u3001\u91cd\u8981\u306a\u30d1\u30e9\u30c0\u30a4\u30e0\u30b7\u30d5\u30c8\u3092\u5f37\u8abf\u3057\u3066\u3044\u307e\u3059\u3002TDM\u306e\u30c7\u30b8\u30bf\u30eb\u5909\u63db\u306f\u4fa1\u5024\u751f\u6210\u8981\u56e0\u3068\u3057\u3066\u6a5f\u80fd\u3057\u3001\u5358\u306b\u30aa\u30fc\u30d0\u30fc\u30d8\u30c3\u30c9\u3092\u767a\u751f\u3055\u305b\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u8a8d\u8b58\u3067\u304d\u308b\u5b9f\u8cea\u7684\u306a\u6295\u8cc7\u53ce\u76ca\u7387(ROI)\u3092\u3082\u305f\u3089\u3057\u307e\u3059\u3002<\/span><\/p>\n<h2 style=\"font-family: Inter !important; font-weight: 500 !important; font-size: 28px !important; line-height: 36px !important; letter-spacing: 0px !important;\">\u5909\u9769\u3078\u306e\u30ed\u30fc\u30c9\u30de\u30c3\u30d7\uff1a\u30ea\u30fc\u30c0\u30fc\u30b7\u30c3\u30d7\u3078\u306e\u884c\u52d5\u306e\u547c\u3073\u304b\u3051<\/h2>\n<p><span style=\"font-weight: 400;\">\u3053\u306e\u91cd\u8981\u306aROI\u3092\u5b9f\u73fe\u3057\u3001\u9ad8\u5ea6\u306a\u8a3a\u65ad\u9023\u7d9a\u4f53\u3092\u7dad\u6301\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u7d44\u7e54\u306e\u6e96\u5099\u3068\u6280\u8853\u7684\u30ac\u30d0\u30ca\u30f3\u30b9\u306e\u4e21\u65b9\u306b\u5bfe\u51e6\u3059\u308b\u614e\u91cd\u3067\u5148\u9032\u7684\u306a\u6226\u7565\u304c\u5fc5\u8981\u3067\u3059\u3002\u691c\u67fb\u5ba4\u3084\u75c5\u9662\u306e\u30ea\u30fc\u30c0\u30fc\u30b7\u30c3\u30d7\u306b\u3068\u3063\u3066\u3001\u524d\u9032\u306e\u9053\u306f\u5358\u306b\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u3092\u5c0e\u5165\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u65bd\u8a2d\u306e\u5909\u5316\u3092\u63a8\u9032\u3059\u308b\u3053\u3068\u3067\u3059\u3002\u3053\u308c\u304c\u9054\u6210\u3055\u308c\u308b\u306b\u306f\u3001\u660e\u78ba\u306a\u4e00\u9023\u306e\u884c\u52d5\u304c\u5fc5\u8981\u3067\u3059\u3002<\/span><\/p>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u5b66\u969b\u7684\u306a\u5354\u529b\uff1a<\/b><span style=\"font-weight: 400;\">\u300c\u7d71\u5408\u3055\u308c\u305f\u30b1\u30a2\u300d\u3068\u3044\u3046\u5168\u4f53\u7684\u5c55\u671b\u3092\u9054\u6210\u3059\u308b\u306b\u306f\u3001\u5f93\u6765\u306e\u30b5\u30a4\u30ed\u3092\u6253\u7834\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u30c4\u30fc\u30eb\u306e\u7d71\u5408\u3068\u30ef\u30fc\u30af\u30d5\u30ed\u30fc\u306e\u63a1\u7528\u3092\u30b7\u30fc\u30e0\u30ec\u30b9\u306b\u78ba\u4fdd\u3059\u308b\u306b\u306f\u3001\u81e8\u5e8a\u85ac\u5c40\u3001\u81e8\u5e8a\u691c\u67fb\u30b5\u30fc\u30d3\u30b9\u3001IT\/\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u958b\u767a\u3001\u75c5\u9662\u7ba1\u7406\u306a\u3069\u306e\u4e3b\u8981\u306a\u30b9\u30c6\u30fc\u30af\u30db\u30eb\u30c0\u30fc\u9593\u3067\u52b9\u679c\u7684\u306a\u5354\u529b\u304c\u4e0d\u53ef\u6b20\u3067\u3059[1]\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u30ac\u30d0\u30ca\u30f3\u30b9\u3068\u54c1\u8cea\u7ba1\u7406\uff1a<\/b><span style=\"font-weight: 400;\"> \u30c7\u30b8\u30bf\u30eb\u6280\u8853\u3001\u7279\u306bAI\u306f\u614e\u91cd\u306a\u7ba1\u7406\u3092\u5fc5\u8981\u3068\u3057\u307e\u3059\u3002\u30ea\u30fc\u30c0\u30fc\u30b7\u30c3\u30d7\u306f\u3001\u30e2\u30c7\u30eb\u3001\u7279\u306bRWD\u3092\u6d3b\u7528\u3059\u308b\u3082\u306e\u304c\u5e45\u5e83\u3044\u60a3\u8005\u30b1\u30a2\u306b\u5b89\u5168\u3067\u4fe1\u983c\u3067\u304d\u308b\u3082\u306e\u3067\u3042\u308b\u3053\u3068\u3092\u4fdd\u8a3c\u3059\u308b\u305f\u3081\u306b\u3001\u30ed\u30d0\u30b9\u30c8\u306a\u30c7\u30fc\u30bf\u54c1\u8cea\u3001\u53b3\u683c\u306a\u5916\u90e8\u691c\u8a3c\u3001\u304a\u3088\u3073\u5f37\u529b\u306a\u30ac\u30d0\u30ca\u30f3\u30b9\u3092\u512a\u5148\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059[8]\u3002\u660e\u78ba\u306a\u30d7\u30ed\u30c8\u30b3\u30eb\u3092\u78ba\u7acb\u3059\u308b\u3053\u3068\u3067\u8cac\u4efb\u3092\u9632\u304e\u3001\u60a3\u8005\u306e\u5b89\u5168\u3092\u78ba\u4fdd\u3057\u307e\u3059\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u6295\u8cc7\u306e\u7126\u70b9\uff1a<\/b><span style=\"font-weight: 400;\">\u300c\u5c06\u6765\u306e\u6295\u8cc7\u306f\u3001\u5b64\u7acb\u3057\u305f\u30c4\u30fc\u30eb\u3092\u8cfc\u5165\u3059\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u30b7\u30b9\u30c6\u30e0\u306e\u7d71\u5408\u306b\u7126\u70b9\u3092\u5f53\u3066\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u306b\u306f\u3001\u5b8c\u5168\u306a\u85ac\u529b\u5b66\uff08PK\/PD\u30e2\u30c7\u30eb\uff09\u3001\u30c7\u30b8\u30bf\u30eb\u30c4\u30a4\u30f3\u306a\u3069\u306e\u9ad8\u5ea6\u306a\u6982\u5ff5\u3001\u304a\u3088\u3073\u81e8\u5e8a\u610f\u601d\u6c7a\u5b9a\u652f\u63f4\u30c0\u30c3\u30b7\u30e5\u30dc\u30fc\u30c9\u3078\u306e\u6d17\u7df4\u3055\u308c\u305fAI\u6a5f\u80fd\u306e\u76f4\u63a5\u306e\u7d71\u5408\u304c\u542b\u307e\u308c\u307e\u3059\u3002\u3053\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u3001TDM\u3092\u3055\u3089\u306b\u8fd1\u4ee3\u5316\u3057\u3001\u5909\u9769\u3057\u3001\u6700\u7d42\u7684\u306a\u76ee\u6a19\u3001\u3059\u3079<\/span><b><i>\u3066\u306e\u60a3\u8005\u306b\u5bfe\u3057\u3066\u9069\u5207\u306a\u85ac\u7269\u3001\u9069\u5207\u306a\u7528\u91cf\u3001\u9069\u5207\u306a\u30bf\u30a4\u30df\u30f3\u30b0<\/i><\/b><span style=\"font-weight: 400;\">[2,3]\u3092\u4fdd\u8a3c\u3057\u307e\u3059\u3002<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">\u3053\u3046\u3057\u305f\u696d\u754c\u306e\u30ea\u30fc\u30c0\u30fc\u306b\u3088\u3063\u3066\u78ba\u8a8d\u3055\u308c\u305fTDM\u306e\u30c7\u30b8\u30bf\u30eb\u306e\u672a\u6765\u306f\u3001\u6700\u7d42\u7684\u306b\u306f\u76ee\u7684\u3092\u6301\u3063\u305f\u7cbe\u5ea6\u306b\u95a2\u3059\u308b\u3082\u306e\u3067\u3059\u3002\u8a3a\u65ad\u304c\u30b1\u30a2\u306b\u304a\u3051\u308b\u7a4d\u6975\u7684\u306a\u7d71\u5408\u30d1\u30fc\u30c8\u30ca\u30fc\u306b\u306a\u308b\u30c1\u30e3\u30f3\u30b9\u3067\u3059\u3002\u3053\u306e\u5909\u9769\u306f\u3001\u6e2c\u5b9a\u53ef\u80fd\u306a\u30ea\u30bf\u30fc\u30f3\u3067\u660e\u78ba\u306a\u7af6\u4e89\u4e0a\u306e\u512a\u4f4d\u6027\u3092\u3082\u305f\u3089\u3057\u307e\u3059\u304c\u3001\u771f\u306e\u30e1\u30ea\u30c3\u30c8\u306f\u3001\u500b\u5225\u5316\u3055\u308c\u305f\u5b89\u5168\u6027\u3092\u8ab0\u306b\u3068\u3063\u3066\u3082\u4e2d\u6838\u7684\u306a\u57fa\u6e96\u306b\u3059\u308b\u3053\u3068\u3067\u3001\u533b\u7642\u7d4c\u9a13\u3092\u6839\u672c\u7684\u306b\u5411\u4e0a\u3055\u305b\u308b\u80fd\u529b\u3067\u3059\u3002<\/span><\/p>\n<hr \/>\n<p><i><span style=\"font-weight: 400;\">\u53c2\u8003\u6587\u732e<\/span><\/i><\/p>\n<p><a href=\"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bcp.14426\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[1] <\/span><\/a><span style=\"font-weight: 400;\">Mizuno, T., Vinks, A.A., Fukuda, T., Rosenheck, R., Wetterland, L., de Leon, J., Hartman, S., Arnold, L.M. and Patino, L.R. (2022) \u2019Clinical implementation of pharmacogenetics and model-informed precision dosing to improve patient care\u2019, <\/span><i><span style=\"font-weight: 400;\">British Journal of Clinical Pharmacology<\/span><\/i><span style=\"font-weight: 400;\">, 88(4), pp. 1418-1426.<\/span><\/p>\n<p><a href=\"https:\/\/docs.google.com\/document\/d\/1BvNl8lAYxfy36xmXXwKktXdTbsklaISkKwx1QEqg9no\/edit?usp=drive_link\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[2]<\/span><\/a><span style=\"font-weight: 400;\"> Moes, D.J. (2025) \u2018Model Informed (precision) dosing of biologics in (hemato)oncology: challenges and opportunities?\u2019, <\/span><i><span style=\"font-weight: 400;\">23rd International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT) Conference<\/span><\/i><span style=\"font-weight: 400;\">.\u30b0\u30e9\u30f3\u30c9\u30fb\u30b3\u30d7\u30bd\u30fc\u30f3\u30fb\u30a6\u30a9\u30fc\u30bf\u30fc\u30d5\u30ed\u30f3\u30c8\u30fb\u30db\u30c6\u30eb\u3001\u30b7\u30f3\u30ac\u30dd\u30fc\u30eb\u30019\u670821\uff5e24\u65e5<\/span><\/p>\n<p><a href=\"https:\/\/docs.google.com\/document\/d\/1Uit7t_CVMWfrXb8H3bizV4Oqs0B3xdEKcnCWdBsj1MQ\/edit?usp=drive_link\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[3]<\/span><\/a><span style=\"font-weight: 400;\"> Mizuno,T.(2025) \u2018Leveraging machine learning and decision support dashboard to facilitate precision dosing in pediatric patient care\u2019, <\/span><i><span style=\"font-weight: 400;\">23rd International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT) Conference<\/span><\/i><span style=\"font-weight: 400;\">.\u30b0\u30e9\u30f3\u30c9\u30fb\u30b3\u30d7\u30bd\u30fc\u30f3\u30fb\u30a6\u30a9\u30fc\u30bf\u30fc\u30d5\u30ed\u30f3\u30c8\u30fb\u30db\u30c6\u30eb\u3001\u30b7\u30f3\u30ac\u30dd\u30fc\u30eb\u30019\u670821\uff5e24\u65e5<\/span><\/p>\n<p><a href=\"https:\/\/academic.oup.com\/ibdjournal\/article\/29\/8\/1342\/6839996?login=false\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[4] <\/span><\/a><span style=\"font-weight: 400;\">Colman, R.J., Xiong, Y., Mizuno, T., Xie, C., Vinks, A.A., Hyams, J.S., Denson, L.A. and Minar, P.(2023) \u2018Model-informed Precision Dosing for Biologics Is Now Available at the Bedside: A Roadmap for Strategies and Considerations for Real-world Implementation\u2019, <\/span><i><span style=\"font-weight: 400;\">Inflammatory Bowel Diseases<\/span><\/i><span style=\"font-weight: 400;\">, 29(1), pp. 119-127. doi: 10.1093\/ibd\/izac063.<\/span><\/p>\n<p><a href=\"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/psp4.12745\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[5]<\/span><\/a><span style=\"font-weight: 400;\"> Maier, C., Hartung, N., Kloft, C., Huisinga, W.and Henrich,W.(2021) \u2018A continued learning approach for model-informed precision dosing: updated models in clinical practice\u2019, <\/span><i><span style=\"font-weight: 400;\">CPT: Pharmacometrics &amp; Systems Pharmacology<\/span><\/i><span style=\"font-weight: 400;\">, 10(4), pp. 311-321.<\/span><\/p>\n<p><a href=\"https:\/\/docs.google.com\/document\/d\/14aw8je3yf181fa3pnVx8u0AWBQldlrt1yC4K3zV2Npg\/edit?usp=drive_link\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[6] <\/span><\/a><span style=\"font-weight: 400;\">Yamada,T.(2025) \u2018Real-World Big Data Insights for Advancing Therapeutic Drug Monitoring and Clinical Toxicology\u2019, <\/span><i><span style=\"font-weight: 400;\">23rd International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT) Conference<\/span><\/i><span style=\"font-weight: 400;\">.\u30b0\u30e9\u30f3\u30c9\u30fb\u30b3\u30d7\u30bd\u30fc\u30f3\u30fb\u30a6\u30a9\u30fc\u30bf\u30fc\u30d5\u30ed\u30f3\u30c8\u30fb\u30db\u30c6\u30eb\u3001\u30b7\u30f3\u30ac\u30dd\u30fc\u30eb\u30019\u670821\uff5e24\u65e5<\/span><\/p>\n<p><a href=\"https:\/\/academic.oup.com\/jac\/article\/78\/10\/2395\/7226352\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[7]<\/span><\/a><span style=\"font-weight: 400;\"> Pai Mangalore, R., Peel, T.N., Udy, A.A. and Peleg, A.Y. (2023) \u2019The clinical application of beta-lactam antibiotic therapeutic drug monitoring in the critical care setting\u2019, Journal of Antimicrobial Chemotherapy, 78(10), pp. 2395-2405\u3002 \u4ee5\u4e0b\u3088\u308a\u5165\u624b\uff1a<\/span><a href=\"https:\/\/doi.org\/10.1093\/jac\/dkad223\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/doi.org\/10.1093\/jac\/dkad223<\/span><\/a><span style=\"font-weight: 400;\">\uff08\u30a2\u30af\u30bb\u30b9\uff1a2026\u5e741\u670826\u65e5\uff09<\/span><\/p>\n<p><a href=\"https:\/\/docs.google.com\/document\/d\/1XDRqjvduAq3dbnFsj_bxBKyy4p0-XekBPtOhiKOAP8o\/edit?usp=drive_link\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[8] <\/span><\/a><span style=\"font-weight: 400;\">Legg,A.(2025) \u2018TDM research in the digital age?\u2019, <\/span><i><span style=\"font-weight: 400;\">23rd International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT) Conference<\/span><\/i><span style=\"font-weight: 400;\">.Grand Copthorne Waterfront Hotel\u3001\u30b7\u30f3\u30ac\u30dd\u30fc\u30eb\u30019\u670821\uff5e24\u65e5\u3002<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6cbb\u7642\u306b\u95a2\u3059\u308b\u5834\u5408\u3001\u81e8\u5e8a\u306e\u4e2d\u5fc3\u7684\u8ab2\u984c\u306f\u3001\u591a\u304f\u306e\u5834\u5408\u3001\u91cd\u8981\u306a\u8cea\u554f\u306b\u6574\u7406\u3055\u308c\u307e\u3059\uff1a\u85ac\u7269\u306e\u91cf\u3068\u3069\u306e\u304f\u3089\u3044\u306e\u671f\u9593\uff1f 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