{"id":140413,"date":"2019-04-30T03:25:00","date_gmt":"2019-04-30T03:25:00","guid":{"rendered":"https:\/\/labinsights.com\/acf_article\/ctdna%eb%8a%94-%ec%a4%91%ea%b5%ad%ec%97%90%ec%84%9c-%ea%b0%80%ec%9e%a5-%ec%b9%98%eb%aa%85%ec%a0%81%ec%9d%b8-%ec%95%94%ea%b3%bc%ec%9d%98-%ec%8b%b8%ec%9b%80%ec%97%90-%ec%83%88%eb%a1%9c%ec%9a%b4\/"},"modified":"2026-02-17T13:08:50","modified_gmt":"2026-02-17T13:08:50","slug":"ctdna-provides-new-confidence-in-fight-against-chinas-deadliest-cancer","status":"publish","type":"acf_article","link":"https:\/\/labinsights.com\/ko\/disease-area\/oncology\/ctdna-provides-new-confidence-in-fight-against-chinas-deadliest-cancer\/","title":{"rendered":"ctDNA\ub294 \uc911\uad6d\uc5d0\uc11c \uac00\uc7a5 \uce58\uba85\uc801\uc778 \uc554\uacfc\uc758 \uc2f8\uc6c0\uc5d0 \uc0c8\ub85c\uc6b4 \uc2e0\ub8b0\ub97c \uc81c\uacf5\ud558\ub294 \uae30\uc220\uc774\ub2e4"},"content":{"rendered":"

\ud3d0\uc554\uc740\u00a0\uc911\uad6d\uc5d0\uc11c \uac00\uc7a5 \ud754\ud558\uba70\u00a0[1] \uc0ac\ub9dd\ub960\ub3c4 \uac00\uc7a5 \ub192\uc740 \uc554\uc774\ub2e4. \uc5ec\ub7ec \uc11c\uad6c \uad6d\uac00\ub4e4\uacfc \ub2ec\ub9ac, \uc911\uad6d\uc5d0\uc11c\ub294 \ud3d0\uc554 \uc9c4\ub2e8 \uac74\uc218\uac00 \uacc4\uc18d \uc99d\uac00\ud558\uace0 \uc788\ub294 \uc0c1\ud669\uc774\ub2e4.\u00a0ctDNA \uae30\uc220\uc744 \ud65c\uc6a9\ud558\uba74 \ud658\uc790 \uce58\ub8cc\uc640 \uc608\ud6c4\ub97c \ud06c\uac8c \ud5a5\uc0c1\uc2dc\ud0ac \uc218 \uc788\ub294 \uc911\uc694\ud55c \uae30\ud68c\ub97c \uc5bb\uc744 \uc218 \uc788\ub2e4. \uc804\ud1b5\uc801\uc73c\ub85c \uc554 \uc9c4\ub2e8\uc744 \ud655\uc815\ud558\uae30 \uc704\ud574\uc11c\ub294 \uc758\uc2ec\ub418\ub294 \uc885\uc591\uc744 \uc0dd\uac80\ud558\uc5ec \uc870\uc9c1\uc744 \uac80\uc0ac\uc2e4 \uc9c4\ub2e8\ud300\uc5d0 \ubcf4\ub0b4 \ubd84\uc11d\ud558\ub294 \ubc29\uc2dd\uc774\ub2e4. \uadf8\ub7ec\ub098 \ub2e8 \ud558\ub098\uc758 \uc791\uc740 \uc870\uc9c1\ub9cc\uc73c\ub85c \uc554\uc744 \uaddc\uc815\ud558\ub294 \uac83\uc740 \ubd80\uc815\ud655\ud560 \uc218 \uc788\uc73c\uba70\u00a0\ud2b9\ud788 \ud3d0\uc554\uc5d0\uc11c\ub294 \ubc18\ubcf5 \uc870\uc9c1 \uc0dd\uac80\uc774 \ud56d\uc0c1 \uac00\ub2a5\ud55c \uac83\uc740 \uc544\ub2c8\ub2e4. \ud658\uc790\uac00 \ud3d0\uc554 \uce58\ub8cc\ub97c \ubc1b\uc740 \uc774\ud6c4\uc5d0\ub294 \ubc18\ubcf5 \uc870\uc9c1 \uc0dd\uac80\uc774 \ub354\uc6b1 \uc5b4\ub824\uc6cc\uc9c0\uba70, \ubaa8\ub4e0 \uce68\uc2b5\uc801 \uc2dc\uc220\uacfc \ub9c8\ucc2c\uac00\uc9c0\ub85c \uc77c\uc815\ud55c \uc704\ud5d8\uc774 \uc874\uc7ac\ud55c\ub2e4. \uc801\uc808\ud55c \uc804\ubb38\uc131\uc744 \uac16\ucd98 \uac80\uc0ac\uc2e4\uc740 \uc774\ub7ec\ud55c \uc0c1\ud669\uc5d0\uc11c \uc758\uc0ac\uc5d0\uac8c \ub9e4\ub825\uc801\uc778 \ub300\uc548\uc744 \uc81c\uacf5\ud560 \uc218 \uc788\ub294 \uacf3\uc774\ub2e4. \ud608\uc561 \ub0b4 \uc21c\ud658 \uc885\uc591 DNA(ctDNA) \uc218\uce58\ub97c \uce21\uc815\ud558\ub294 \uc561\uccb4 \uc0dd\uac80\uc740 \uce68\uc2b5\uc131\uc774 \ub0ae\uace0 \uc0dd\uac80 \uad00\ub828 \ud569\ubcd1\uc99d\uc744 \ud53c\ud560 \uc218 \uc788\ub294 \ubc29\ubc95\uc774\ub2e4. ctDNA\uc5d0\uc11c \uc5bb\uc740 \uc720\uc804 \ubc0f \ud6c4\uc131\uc720\uc804 \uc815\ubcf4\ub294 \uac80\uc0ac\uc2e4 \ud300\uc774 \uc554\uc758 \uc720\uc804\uc790\ud615\uacfc \uc2e4\uc2dc\uac04 \ud589\ub3d9 \uc591\uc0c1\uc5d0 \ub300\ud55c \uace0\ud488\uc9c8 \uc815\ubc00 \ub370\uc774\ud130\ub97c \uc81c\uacf5\ud560 \uc218 \uc788\uac8c \ud558\uba70, \uc774\ub294 \uc885\uc591\ub0b4\uacfc \uc804\ubb38\uc758\uac00 \uc9c8\ud658\uc744 \ub354 \ud6a8\uacfc\uc801\uc73c\ub85c \uad00\ub9ac\ud558\ub3c4\ub85d \ub3d5\ub294 \uae30\ubc18\uc774 \ub41c\ub2e4.<\/p>\n

\ud608\uc561 \ud55c \ubc14\uc774\uc54c\uc5d0 \ub2f4\uae34 \uc815\ubcf4 \ud574\ub3c5<\/h2>\n

ctDNA\uc758 \ubc18\uac10\uae30\ub294 1\uc2dc\uac04 \uc774\ud558\ub85c \ub9e4\uc6b0 \uc9e7\uae30 \ub54c\ubb38\uc5d0, \uce58\ub8cc \ubc18\uc751\uc5d0 \ub530\ub978 \uc2e4\uc2dc\uac04 \uc885\uc591 \ubd80\ub2f4\uc744 \uc815\ud655\ud558\uac8c \ubc18\uc601\ud560 \uc218 \uc788\ub294 \uc9c0\ud45c\uc774\ub2e4 [2]. \uc774\ub7ec\ud55c \uc2e4\uc2dc\uac04 \uc815\ubcf4\ub294 \uc9c4\ub8cc\ud300\uc774 \uc794\uc874 \uc9c8\ud658\uc744 \uc870\uae30\uc5d0 \ubc1c\uacac\ud560 \uc218 \uc788\ub3c4\ub85d \ud558\ub294 \uc911\uc694\ud55c \uadfc\uac70\uac00 \ub41c\ub2e4. \uc2e4\uc81c\ub85c\u00a0\uad6d\uc18c \ud3d0\uc554 \ud658\uc790\uc758 72%\uc5d0\uc11c ctDNA\ub97c \ud65c\uc6a9\ud558\uba74 \uc601\uc0c1 \uac80\uc0ac\ub97c \ub2e8\ub3c5\uc73c\ub85c \uc0ac\uc6a9\ud560 \ub54c\ubcf4\ub2e4 \ud3c9\uade0 5.2\uac1c\uc6d4 \uba3c\uc800 \uc794\uc874 \uc9c8\ud658\uc744 \ud655\uc778\ud560 \uc218 \uc788\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\ub2e4 [3]. EGFR \ubcc0\uc774\uac00 \uc788\ub294 \ube44\uc18c\uc138\ud3ec\ud3d0\uc554 \ud658\uc790\uc758 \uacbd\uc6b0\u00a0\ud2f0\ub85c\uc2e0 \ud0a4\ub098\uc81c \uc5b5\uc81c\uc81c \uce58\ub8cc\uc5d0 \ub300\ud55c \ub0b4\uc131 \ubc1c\uc0dd\uc740 \uc9c8\ud658\uc758 \uc720\uc804\uc801 \ubcc0\ud654\ub97c \uc2e4\uc2dc\uac04\uc73c\ub85c \ubaa8\ub2c8\ud130\ub9c1\ud558\uae30 \uc704\ud574 ctDNA\ub97c \ud65c\uc6a9\ud560 \uc218 \uc788\ub294 \ub610 \ud558\ub098\uc758 \uae30\ud68c\uc774\ub2e4. \ud2f0\ub85c\uc2e0 \ud0a4\ub098\uc81c \uc5b5\uc81c\uc81c\ub97c \ud22c\uc5ec\ubc1b\ub294 \ud658\uc790\uc758 \uc808\ubc18\uc740 EGFR T790M \ubcc0\uc774\ub97c \uc0c8\ub86d\uac8c \ud68d\ub4dd\ud558\uac8c \ub41c\ub2e4 [4]. Wakelee \ub4f1\uc740 ASCO 2016 \ubc1c\ud45c\uc5d0\uc11c[5]\u00a0\ud608\uc7a5 \ubc0f \uc18c\ubcc0 EGFR \ubd84\uc11d\uc774 \uc774\ub7ec\ud55c \ubcc0\uc774\ub97c \uc815\ud655\ud788 \uac80\ucd9c\ud560 \uc218 \uc788\uc73c\uba70, \uc885\uc591\uc758 \uc774\uc9c8\uc131 \ub54c\ubb38\uc5d0 \uc870\uc9c1 \uc0dd\uac80\uc5d0\uc11c \ud655\uc778\ub418\uc9c0 \uc54a\uc744 \ub54c \uc774\ub97c \ubc1c\uacac\ud560 \uc218 \uc788\ub2e4\ub294 \uc810\uc744 \uc785\uc99d\ud558\uc600\ub2e4 \ub610\ud55c\u00a0Zheng \ub4f1\uc740 ctDNA\uac00 \uc784\uc0c1\uc801 \uc9c8\ud658 \uc9c4\ud589\ubcf4\ub2e4 \ud3c9\uade0 2.2\uac1c\uc6d4 \uba3c\uc800 \uc774\ub7ec\ud55c \ud658\uc790\ub97c \uc2dd\ubcc4\ud560 \uc218 \uc788\uc74c\uc744 \ubcf4\uc5ec\uc8fc\uc5c8\ub2e4 [4].<\/p>\n

\uc784\uc0c1\uacfc \uac80\uc0ac\uc2e4\uc758 \uae34\ubc00\ud55c \ud611\ub825<\/h2>\n

\ubaa8\ub4e0 \uc0c8\ub85c\uc6b4 \uae30\uc220\uacfc \ub9c8\ucc2c\uac00\uc9c0\ub85c ctDNA \uac80\uc0ac\ub97c \uc5b8\uc81c \uc801\uc6a9\ud558\uace0\u00a0\uadf8 \uacb0\uacfc\ub97c \uc5b4\ub5bb\uac8c \ubd84\uc11d\ud558\uace0 \ud574\uc11d\ud560 \uac83\uc778\uc9c0\ub294 \ud575\uc2ec \uc694\uc18c\uc774\ub2e4. \ucd5c\uc2e0 \uc5f0\uad6c\uc5d0 \uc815\ud1b5\ud558\uace0 \uace0\ud488\uc9c8 \uc815\ubc00 \ubd84\uc11d\uc744 \uc218\ud589\ud558\ub3c4\ub85d \ud6c8\ub828\ub41c \uac80\uc0ac\uc2e4 \ud300\uc740 \uc885\uc591\ub0b4\uacfc \uc804\ubb38\uc758\uac00 \ud658\uc790\uc758 \uc9c8\ud658\uc744 \ub354 \ud6a8\uacfc\uc801\uc73c\ub85c \uad00\ub9ac\ud558\ub3c4\ub85d \ub3d5\ub294 \uc911\uc694\ud55c \ud30c\ud2b8\ub108\uc774\ub2e4 ctDNA \ubd84\uc11d\uc740 \ud658\uc790 \uc0ac\ub840\uc758 49%\uc5d0\uc11c FDA \uc2b9\uc778 \uc57d\ubb3c\uc5d0 \ud65c\uc6a9\ub420 \uc218 \uc788\ub294 \uc554 \ubcc0\uc774\ub97c \uc2dd\ubcc4\ud558\ub294 \uac83\uc73c\ub85c \ubcf4\uace0\ub41c\ub2e4 [6]. \uac80\uc0ac\uc2e4 \uc758\ud559 \uc804\ubb38\uac00\ub294 \uc561\uccb4 \uc0dd\uac80\uc774 \uac00\uc7a5 \uc801\uc808\ud55c \uc9c4\ub2e8 \ub3c4\uad6c\uac00 \ub418\ub294 \uc2dc\uc810\uc744 \ud310\ub2e8\ud558\uae30 \uc704\ud574 \uc885\uc591\ub0b4\uacfc \uc804\ubb38\uc758\uc640 \uae34\ubc00\ud558\uac8c \ud611\ub825\ud574\uc57c \ud558\ub294 \uc704\uce58\uc5d0 \uc788\ub2e4. \uc6b0\ub9ac\ub294 \uc9c4\ub2e8 \uc2dc\uc810\ubfd0 \uc544\ub2c8\ub77c \uc9c8\ubcd1\uc758 \uc804\uccb4 \uacbd\uacfc \ub3d9\uc548 \ud658\uc790 \ub9de\ucda4\ud615 \uce58\ub8cc\ub97c \uc81c\uacf5\ud560 \uc218 \uc788\ub294 \uc804\ud658\uc810\uc5d0 \uc640 \uc788\ub294 \uc0c1\ud669\uc774\ub2e4. ctDNA\ub294 \uc554\uc758 \uc720\uc804\uc801 \uad6c\uc131\uacfc\u00a0\uace0\uc720\ud55c \uc774\uc9c8\uc131\uc5d0 \ub300\ud55c \uc911\uc694\ud55c \uc815\ubcf4\ub97c \uc81c\uacf5\ud55c\ub2e4. \ub610\ud55c ctDNA\ub294 \uc7ac\ubc1c \uc704\ud5d8\uacfc \uc804\uccb4 \uc0dd\uc874\uc728\uc744 \ud3ec\ud568\ud55c \uc608\ud6c4\uc5d0 \ub300\ud55c \ub2e8\uc11c\ub97c \uc81c\uacf5\ud558\ub294 \uc790\ub8cc\uac00 \ub420 \uc218 \uc788\ub2e4. \uac80\uc0ac\uc2e4\uc5d0\uc11c \uc81c\uacf5\ud558\ub294 \uc815\ud655\ud558\uace0 \uc2e0\ub8b0\ub3c4 \ub192\uc740 \uc815\ubcf4\uac00 \uc788\ub2e4\uba74, \uc885\uc591\ub0b4\uacfc \uc804\ubb38\uc758\ub294 \ud658\uc790\uac00 \ub358\uc9c0\ub294 \uac00\uc7a5 \uc5b4\ub824\uc6b4 \uc9c8\ubb38\ub4e4\uc5d0 \ub300\ud574 \ub354 \ub192\uc740 \ud655\uc2e0\uacfc \uc815\ud655\uc131\uc744 \uac00\uc9c0\uace0 \ub2f5\ud560 \uc218 \uc788\uac8c \ub420 \uac83\uc774\ub2e4.<\/p>\n

References:<\/em><\/p>\n

[1]<\/a>\u00a0Zhou, C., 2014. Lung cancer molecular epidemiology in China: recent trends.\u00a0Translational Lung Cancer Research<\/i>, 3(5), pp.270-279.<\/p>\n

[2]<\/a> Corcoran, B.R., Chabner A.B., 2018. Application of Cell-free DNA Analysis to Cancer Treatment. New England Journal of Medicine<\/em>, 379, pp.1754-1765<\/p>\n

[3]<\/a> Chaudhuri, A.A, et al., 2018. Early Detection of Molecular Residual Disease in Localized Lung Cancer by Circulating Tumor DNA Profiling. American Association for Cancer Research<\/em>, 7(12), pp.1394-1403.<\/p>\n

[4]<\/a> Zheng, X.Y, et al., 2016. Plasma EGFR<\/em> T790M ctDNA status is associated with clinical outcome in advanced NSCLC patients with acquired EGFR-TKI resistance. Scientific Reports<\/em>, 6, 20913.<\/p>\n

[5]<\/a> Wakelee, A.H., et al., 2016.\u00a0Epidermal growth factor receptor (EGFR) genotyping of matched urine, plasma and tumor tissue from non-small cell lung cancer (NSCLC) patients (pts) treated with rociletinib. Journal of Clinical Oncology<\/em>, 34(15) supplementary<\/em>, pp.9001-9001.<\/p>\n

[6]<\/a> Zill, A.O., et al., 2016.\u00a0Somatic genomic landscape of over 15,000 patients with advanced-stage cancer from clinical next-generation sequencing analysis of circulating tumor DNA. Journal of Clinical Oncology<\/em>, 34(18), supplementary,<\/em>\u00a0LBA11501<\/p>\n

\n

This article is based on a presentation “Conquering Cancer: ctDNA\u2019s application in NSCLC”\u00a0at the Belt and Road Diagnostic Summit Forum 2018 in Suzhou, China.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

\ud3d0\uc554\uc740\u00a0\uc911\uad6d\uc5d0\uc11c \uac00\uc7a5 \ud754\ud558\uba70\u00a0[1] \uc0ac\ub9dd\ub960\ub3c4 \uac00\uc7a5 \ub192\uc740 \uc554\uc774\ub2e4. \uc5ec\ub7ec \uc11c\uad6c \uad6d\uac00\ub4e4\uacfc \ub2ec\ub9ac, \uc911\uad6d\uc5d0\uc11c\ub294 \ud3d0\uc554 \uc9c4\ub2e8 \uac74\uc218\uac00 \uacc4\uc18d \uc99d\uac00\ud558\uace0 \uc788\ub294 \uc0c1\ud669\uc774\ub2e4.\u00a0ctDNA \uae30\uc220\uc744 \ud65c\uc6a9\ud558\uba74 \ud658\uc790 \uce58\ub8cc\uc640 \uc608\ud6c4\ub97c \ud06c\uac8c \ud5a5\uc0c1\uc2dc\ud0ac \uc218 \uc788\ub294 \uc911\uc694\ud55c \uae30\ud68c\ub97c \uc5bb\uc744 \uc218 \uc788\ub2e4. \uc804\ud1b5\uc801\uc73c\ub85c \uc554 \uc9c4\ub2e8\uc744 \ud655\uc815\ud558\uae30 \uc704\ud574\uc11c\ub294 \uc758\uc2ec\ub418\ub294 \uc885\uc591\uc744 \uc0dd\uac80\ud558\uc5ec \uc870\uc9c1\uc744 \uac80\uc0ac\uc2e4 \uc9c4\ub2e8\ud300\uc5d0 \ubcf4\ub0b4 \ubd84\uc11d\ud558\ub294 \ubc29\uc2dd\uc774\ub2e4. \uadf8\ub7ec\ub098 \ub2e8 \ud558\ub098\uc758 \uc791\uc740 \uc870\uc9c1\ub9cc\uc73c\ub85c \uc554\uc744 \uaddc\uc815\ud558\ub294 \uac83\uc740 […]<\/p>\n","protected":false},"author":1,"featured_media":83494,"parent":0,"menu_order":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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