{"id":140421,"date":"2019-04-30T05:42:31","date_gmt":"2019-04-30T05:42:31","guid":{"rendered":"https:\/\/labinsights.com\/acf_article\/%eb%b9%84-%ec%b9%a8%ec%8a%b5%ec%a0%81-%ec%82%b0%ec%a0%84-%ea%b2%80%ec%82%acnipt-%ea%b8%b0%ec%88%a0%ec%9d%98-%eb%b0%9c%ec%a0%84\/"},"modified":"2026-03-03T09:49:12","modified_gmt":"2026-03-03T09:49:12","slug":"the-evolution-of-non-invasive-prenatal-test-technologies","status":"publish","type":"acf_article","link":"https:\/\/labinsights.com\/ko\/operations\/sequencing\/the-evolution-of-non-invasive-prenatal-test-technologies\/","title":{"rendered":"\ube44-\uce68\uc2b5\uc801 \uc0b0\uc804 \uac80\uc0ac(NIPT) \uae30\uc220\uc758 \ubc1c\uc804"},"content":{"rendered":"

\uc0b0\uc804 \uc9c4\ucc30\uc740 \ub300\uccb4\ub85c \uae30\uc05c \uc790\ub9ac\uc774\uc9c0\ub9cc, \ubaa8\ub4e0 \uc784\uc2e0\uc5d0\ub294 \uc5fc\uc0c9\uccb4 \uc774\uc0c1 \uc704\ud5d8\uc774 \ub530\ub974\uae30 \ub54c\ubb38\uc5d0 \ub9ce\uc740 \uc5ec\uc131\ub4e4\uc774 \uc5ec\uc804\ud788 \ubd88\uc548\uc744 \ub290\ub07c\uae30\ub3c4 \ud55c\ub2e4. \ub2e4\ud589\ud788 \ube44-\uce68\uc2b5\uc801 \uc0b0\uc804 \uac80\uc0ac(NIPT) \uae30\uc220\uc774 \ubc1c\uc804\ud558\uba74\uc11c \uac80\uc0ac \uacfc\uc815\uc740 \uadf8 \uc5b4\ub290 \ub54c\ubcf4\ub2e4 \ub354 \ud3b8\ub9ac\ud558\uace0 \uc2e0\ub8b0\ud560 \uc218 \uc788\uac8c \ub418\uc5c8\ub2e4.<\/p>\n

NIPT\ub97c \uc704\ud55c cfDNA \ubd84\uc11d\uc758 \ubd80\uc0c1<\/h2>\n

1990\ub144\ub300\uc5d0 \ub3c4\uc785\ub41c \uc774\ud6c4, 1\ucc28 \uae30\ud615\uc544 \uac80\uc0ac(FTS)\ub294 \uc0b0\uc804 \uac80\uc0ac\uc5d0\uc11c \ub110\ub9ac \uc0ac\uc6a9\ub418\ub294 \ubc29\ubc95\uc774\uc5c8\ub2e4. \uc774 \ubc29\ubc95\uc740 \uc784\uc2e0 11 \uc8fc\uc5d0\uc11c 13 \uc8fc \uc0ac\uc774\uc5d0 \uc2dc\ud589\ub418\ub294 \ud608\uccad \uc0dd\ud654\ud559 \uac80\uc0ac\uc640 \ud0dc\uc544 \ubaa9\ub35c\ubbf8 \ud22c\uba85\ub300 \uce21\uc815\uce58\ub97c \ud568\uaed8 \ud65c\uc6a9\ud55c\ub2e4. \uc774\ub97c \ud1b5\ud574 [1]\u00a0\ub2e4\uc6b4\uc99d\ud6c4\uad70(21 \uc0bc\uc5fc\uc0c9\uccb4\uc99d)\uacfc \uc5d0\ub4dc\uc6cc\ub4dc\uc99d\ud6c4\uad70(18 \uc0bc\uc5fc\uc0c9\uccb4\uc99d)\uacfc \uac19\uc740 \ud754\ud55c \uc5fc\uc0c9\uccb4 \uc774\uc0c1\uc744 \uc2e0\ub8b0\ub3c4 \uc788\uac8c \uc120\ubcc4\ud560 \uc218 \uc788\ub2e4. \ud0dc\uad6d \uc2dc\ub9ac\ub78f \ubcd1\uc6d0 \uc0b0\ubd80\uc778\uacfc\uc758 Dr Tachjaree Panchalee\ub294 2018\ub144 NIPT Forum Asia\uc5d0\uc11c, FTS\uac00 \uc720\uc6a9\ud55c \ub3c4\uad6c\uc774\uae34 \ud558\uc9c0\ub9cc \uc704\uc591\uc131\ub960\uc774 \ub192\uace0 \uc591\uc131\uc608\uce21\ub3c4\uac00 \ub0ae\ub2e4\ub294 \ud55c\uacc4\ub97c \uac16\uace0 \uc788\ub2e4\uace0 \uc124\uba85\ud588\ub2e4.\u00a0FTS\ub294 84\u201390%\uc758 \uac80\ucd9c\ub960\uacfc 5%\uc758 \uc704\uc591\uc131\ub960\uc744 \ubcf4\uc774\ub294 \uac83\uc73c\ub85c \ud655\uc778\ub418\uc5c8\uc73c\uba70[2], \uc774\ub294 \ub300\ube44\uac00 \uc804\ud600 \uc5c6\ub294 \uac83\ubcf4\ub2e4\ub294 \ub0ab\uc9c0\ub9cc \ucd5c\uc801\uc774\ub77c \ubcf4\uae30\ub294 \uc5b4\ub835\ub2e4. \uadf8\ub7ec\ub098 2011\ub144\ubd80\ud130 FTS\uc5d0 \ub3c4\uc804\ud558\ub294 \uc0c8\ub85c\uc6b4 \ubc29\uc2dd\ub4e4\uc774 \ub4f1\uc7a5\ud558\uae30 \uc2dc\uc791\ud588\ub2e4. \uc774\ub7ec\ud55c \ubc29\ubc95\ub4e4\uc740 \uc138\ud3ec\uc720\ub9ac DNA(cfDNA) \ubd84\uc11d\uc744 \uae30\ubc18\uc73c\ub85c \ud0dc\uc544\uc758 \uc5fc\uc0c9\uccb4 \uc774\uc0c1\uc744 \ube44\uce68\uc2b5\uc801\uc73c\ub85c \uc120\ubcc4\ud55c\ub2e4. \u201c[FTS]\ub294 \uc138\ud3ec\uc720\ub9ac DNA \uac80\uc0ac\ub85c \ub300\uccb4\ub418\uc5c8\ub2e4\u201d\ub77c\uace0 \uc911\uad6d \ud64d\ucf69\uc911\ubb38\ub300\ud559\uad50 \uc0b0\ubd80\uc778\uacfc\uc758\u00a0Professor Liona Poon\uc740 \uac19\uc740 \ud589\uc0ac\uc5d0\uc11c \ub9d0\ud588\ub2e4. \ud0dc\ubc18 DNA \uc870\uac01\uc740 \uc0b0\ubaa8 \ud608\uc561 \ub0b4 \ucd1d cfDNA\uc758 \ud3c9\uade0 \uc57d 13%[3]\ub97c \ucc28\uc9c0\ud55c\ub2e4. 150~200 \uc5fc\uae30\uc30d \uae38\uc774\uc758 \ud0dc\uc544 DNA \uc870\uac01\uc740 [4]\u00a0\u00a0\uc784\uc2e0 32\uc77c \ubb34\ub835\ubd80\ud130 \uc0b0\ubaa8 \ud608\uc561\uc5d0\uc11c \ubc1c\uacac\ub420 \uc218 \uc788\uc73c\uba70, \uc2dc\uac04\uc774 \uc9c0\ub0a0\uc218\ub85d \uadf8 \uc591\uc774 \uc99d\uac00\ud55c\ub2e4[5]. \uc774\ub7ec\ud55c \uc870\uac01\uc740 \ubd84\ub9cc \ud6c4 \uc57d 2\uc2dc\uac04 \uc815\ub3c4 \uc9c0\ub098\uba74 \uc0b0\ubaa8 \ud608\uc561\uc5d0\uc11c \uc0ac\ub77c\uc9c4\ub2e4 [3]. \uc0b0\ubaa8\uc640 \ud0dc\uc544\uc758 cfDNA\ub97c \ubd84\uc11d\ud558\uba74, \uac80\uc0ac \uc804\ubb38\uc758\uac00 \ud0dc\uc544\uc758 \uc5fc\uc0c9\uccb4 \uc774\uc0c1\uc744 \ube44\uce68\uc2b5\uc801\uc73c\ub85c \uc815\ud655\ud558\uac8c \ud3c9\uac00\ud560 \uc218 \uc788\ub2e4. cfDNA \ubd84\uc11d\uc5d0 \ub2a5\uc219\ud55c \uac80\uc0ac\uc2e4\uc740 \uc0c8\ub85c\uc6b4 \uc801\uc6a9 \ubd84\uc57c\uc758 \ucd5c\uc804\uc120\uc5d0 \uc124 \uc218 \uc788\uc73c\uba70, \uc0b0\ubd80\uc778\uacfc \ud30c\ud2b8\ub108\ub4e4\uc5d0\uac8c \ub354\uc6b1 \uc120\uc81c\uc801\uc73c\ub85c \uac00\uce58\ub97c \uc81c\uacf5\ud560 \uc218 \uc788\ub2e4. \uac80\uc99d\ub41c \ucc38\uc870 \ub77c\uc774\ube0c\ub7ec\ub9ac\uac00 \ud655\ub300\ub428\uc5d0 \ub530\ub77c, cfDNA \uac80\uc0ac\uc758 \uc801\uc6a9 \ubc94\uc704\ub294 \uc55e\uc73c\ub85c \ub2e4\ub978 \uc5fc\uc0c9\uccb4 \uc774\uc0c1\uc73c\ub85c\ub3c4 \ud655\uc7a5\ub420 \uc218 \uc788\ub2e4. \u201c\ubaa8\ub4e0 \uc5ec\uc131\uc740 \uc2a4\uc2a4\ub85c \uc120\ud0dd\ud560 \uad8c\ub9ac\uac00 \uc788\uc73c\ubbc0\ub85c, \uc81c\uacf5 \uac00\ub2a5\ud55c \uc120\ubcc4 \ub3c4\uad6c\uc5d0 \ub300\ud574 \ucd5c\uc2e0 \uc815\ubcf4\ub97c \uc720\uc9c0\ud558\ub294 \uac83\uc740 \uc758\ub8cc\uc778\uc758 \ucc45\uc784\uc774\ub2e4\u201d\ub77c\uace0 Dr Panchalee\ub294\u00a0\ub367\ubd99\uc600\ub2e4.<\/p>\n

cfDNA \uc811\uadfc\ubc95<\/h2>\n

\uc0c8\ub85c\uc6b4 \ubc1c\uacac\uc774 \ub298 \uadf8\ub807\ub4ef, NIPT\ub97c \uc704\ud55c \ub2e4\uc591\ud55c \ubc29\ubc95\ub4e4\uc774 \ud45c\uc900 \uc9c0\uc704\ub97c \ub450\uace0 \uacbd\uc7c1\ud558\uace0 \uc788\ub2e4. \uc774\ub294 \uc804\uc7a5 \ubc0f \ud2b9\uc815 \uc5fc\uc0c9\uccb4 \uc2dc\ud000\uc2f1\ubd80\ud130 \ub9c8\uc774\ud06c\ub85c\uc5b4\ub808\uc774 \uae30\ubc18 \ud50c\ub7ab\ud3fc\uae4c\uc9c0 \ub2e4\uc591\ud558\ub2e4. \uac00\uc7a5 \ucd08\uae30\ubd80\ud130 \uc0ac\uc6a9\ub41c \uae30\uc220 \uc911 \ud558\ub098\ub294 \ub300\ub7c9 \ubcd1\ub82c(\u201cshotgun\u201d) \uc2dc\ud000\uc2f1\uc774\ub2e4. \uc774 \ubc29\ubc95\uc740 \ud2b9\uc815 \ud45c\uc801 \uad6c\uc5ed\uc744 \ub300\uc0c1\uc73c\ub85c \ud558\uc9c0 \uc54a\uc73c\uba70, \uc0b0\ubaa8 \ud608\uc7a5\uc5d0 \uc874\uc7ac\ud558\ub294 \ubaa8\ub4e0 cfDNA \uc870\uac01\uc758 \uc804\uc720\uc804\uccb4\ub97c \ud3c9\uac00\ud55c\ub2e4. \uc804\uc7a5\uc720\uc804\uccb4\uc2dc\ud000\uc2f1\uc5d0\uc11c\ub294[6] \uc218\ucc9c\ub9cc \uac1c\uc758 \uc2dc\ud000\uc2f1 \ub9ac\ub4dc\uac00 \uc778\uac04 \ucc38\uc870 \ub77c\uc774\ube0c\ub7ec\ub9ac\uc5d0 \uc815\ub82c\u00b7\ub9e4\ud551\ub418\uc5b4, \ud68d\ub4dd\ub41c \ub370\uc774\ud130\uac00 \uc5b4\ub5a4 \uc5fc\uc0c9\uccb4\uc5d0\uc11c \uc720\ub798\ud588\ub294\uc9c0 \ud655\uc778\ub41c\ub2e4. \uc774\ud6c4 \ub9e4\ud551\ub41c \ub370\uc774\ud130\ub97c \uc9d1\uacc4\ud558\uc5ec \ud0dc\uc544\uac00 \uc5fc\uc0c9\uccb4 \uc774\uc0c1\uc744 \uac00\uc9c0\uace0 \uc788\ub294\uc9c0 \uc5ec\ubd80\ub97c \ud310\ub2e8\ud55c\ub2e4.<\/p>\n

\"1\"
Massive parallel sequencing assesses whole genome of all cfDNA in maternal blood<\/figcaption><\/figure>\n

\u201c\ub300\ub7c9 \ubcd1\ub82c \uc2dc\ud000\uc2f1\uc758 \uacbd\uc6b0, \uad00\uc2ec \uc601\uc5ed\uc744 \uc815\ud655\ud788 \ubd84\uc11d\ud558\uae30 \uc704\ud574 \ucda9\ubd84\ud55c \ub370\uc774\ud130\ub97c \uc0dd\uc131\ud558\ub824\uba74 \uc0d8\ud50c\ub2f9 \uc57d 2,500\ub9cc \uac1c\uc758 \uc6d0\uc2dc \uc2dc\ud000\uc2f1 \ubaa9\ub85d[7]\uc774 \ud544\uc694\ud558\ub2e4\u201d\uace0 Dr. Panchalee\ub294 \uc124\uba85\ud588.\u00a0\u201c\uc774 \uc811\uadfc\ubc95\uc740 \uc784\uc0c1\uc801\uc73c\ub85c \uc758\ubbf8 \uc788\ub294 \uc5fc\uc0c9\uccb4\uac00 \uc804\uccb4 \uc720\uc804\uccb4\uc758 14%\uc5d0 \ubd88\uacfc\ud558\ub2e4\ub294 \uc810\uc744 \uace0\ub824\ud558\uba74, \uc5c4\uccad\ub09c \uc911\ubcf5\uc131\uc744 \ub098\ud0c0\ub0b8\ub2e4[7].\u201d \uc0c8\ub85c\uc6b4 \uae30\uc220\ub4e4\uc774 \ub4f1\uc7a5\ud558\uace0 \uc788\uc73c\uba70, \uc5ec\uae30\uc5d0\ub294 ion torrent \ud50c\ub7ab\ud3fc\uacfc \uac19\uc740 \ubc18\ub3c4\uccb4 \uc2dc\ud000\uc2f1 \uae30\uc220\ub3c4 \ud3ec\ud568\ub41c\ub2e4. \uc5ec\ub7ec \ud50c\ub7ab\ud3fc\uc774 \uc874\uc7ac\ud558\uc9c0\ub9cc, \ub450 \uae30\uc220\uc744 \ube44\uad50\ud55c \uc5f0\uad6c\uc5d0\uc11c\ub294 [8]\u00a0\uc2dc\ud000\uc2f1 \uc591\uacfc \uc77c\ubc18\uc801\uc774\uba70 \uacac\uace0\ud55c \ud1b5\uacc4 \ubd84\uc11d \uc801\uc6a9\uc774 \ud2b9\uc815 \uc2dc\ud000\uc2f1 \ud654\ud559\uc774\ub098 \ud50c\ub7ab\ud3fc\ubcf4\ub2e4 \uc815\ud655\ud55c \uacb0\uacfc\ub97c \ubcf4\uc7a5\ud558\ub294 \ub370 \ub354 \uc911\uc694\ud558\ub2e4\ub294 \uc0ac\uc2e4\uc774 \ubc1d\ud600\uc84c\ub2e4. \ucd5c\uadfc\uc5d0\ub294 microarray \ubd84\uc11d\uc774 cfDNA \uac80\uc0ac\uc5d0 \uc801\uc6a9\ub418\uae30 \uc2dc\uc791\ud588\ub2e4. \uc774\ub97c \ud1b5\ud574 \uc120\ud0dd\ub41c \uc601\uc5ed\uc744 \ub514\uc9c0\ud138 \ubc29\uc2dd\uc73c\ub85c \ubd84\uc11d\ud558\uc5ec 21, 18, 13 \uc0bc\uc5fc\uc0c9\uccb4\uc99d \ubc0f \uc131\uc5fc\uc0c9\uccb4 \uc774\uc0c1\uc744 \ud3ec\ud568\ud55c \ud2b9\uc815 \uc5fc\uc0c9\uccb4 \uc774\uc0c1\uc744 \ud655\uc778\ud560 \uc218 \uc788\ub2e4.<\/p>\n

\"2\"
Microarray analysis versus sequencing for detection of digital analysis of selected regions<\/figcaption><\/figure>\n

NGS\uc640 \uc9c1\uc811 \ube44\uad50\ud55c \ubd84\uc11d\uc5d0\uc11c, microarray \ubd84\uc11d\uc740 NGS\ubcf4\ub2e4 [9]\u00a0cfDNA \ubd84\uc11d\uc774 \ub354 \ube60\ub974\uace0 \uc815\ud655\ud55c \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\ub2e4. \uac01 \uc2dc\ub8cc\ub294 \uac01 sub-array\uc5d0\uc11c \ub2e8\uc77c\ud50c\ub809\uc2a4\ub85c \ubd84\uc11d\ub418\uc5b4, \uc2dc\ub8cc \ubd84\uc11d \uacfc\uc815\uc744 \ub2e8\uc21c\ud558\uace0 \ube44\uc6a9 \ud6a8\uc728\uc801\uc73c\ub85c \ub9cc\ub4e0\ub2e4. \uc774 \ubc29\ubc95\uc740 \ub2e4\uc591\ud55c \uc0b0\uacfc \uc778\uad6c \uc9d1\ub2e8\uc744 \ub300\uc0c1\uc73c\ub85c \ud55c \uc804\ud5a5\uc801 \uc784\uc0c1 \uc2dc\ud5d8\uc5d0\uc11c \uad11\ubc94\uc704\ud558\uac8c \uac80\uc99d\ub418\uc5c8\ub2e4. \u201c\uc2dc\uc2a4\ud15c\uc758 \ub0b4\ubd80 \uac80\uc99d \uacb0\uacfc, \ub192\uc740 \uc815\ud655\ub3c4\uc640 \ud2b9\uc774\ub3c4\ub97c \ubcf4\uc5ec\uc8fc\uc5c8\uc73c\uba70, \uc704\uc591\uc131\uc774\ub098 \uc704\uc74c\uc131\uc740 \uc5c6\uc5c8\ub2e4\u201d\uace0 Dr Panchalee\uac00 \ud655\uc778\ud588\ub2e4. \ucd5c\uadfc \ub4f1\uc7a5\ud55c \ucd5c\uc2e0 \uae30\uc220\uc740 \ub2e8\uc77c DNA \ubd84\uc790\ub97c \uc774\ubbf8\uc9d5\ud558\ub294 6\ub2e8\uacc4 \uacfc\uc815\uc73c\ub85c[10],\u00a0cfDNA \uac80\uc0ac \ubcf5\uc7a1\uc131\uc744 \uc904\uc5ec\uc900\ub2e4. \uc774 \uae30\uc220\uc740 \ud45c\uc801 \uc5fc\uc0c9\uccb4\ub97c \ud45c\uc9c0\ud558\uae30 \uc704\ud55c \uc0c8\ub85c\uc6b4 \ubd84\uc790 \ud504\ub85c\ube0c \uae30\uc220\uacfc \ub098\ub178\ud544\ud130\ub97c \uc774\uc6a9\ud55c \uc0c8\ub85c\uc6b4 \ud310\ub3c5 \ubc29\uc2dd\uc744 \uacb0\ud569\ud55c\ub2e4. \uc774\ub97c \ud1b5\ud574 DNA \uc99d\ud3ed, microarray \ub610\ub294 \uc2dc\ud000\uc2f1 \uc5c6\uc774\ub3c4 \ub2e8\uc77c \ubd84\uc790\ub97c \uc774\ubbf8\uc9d5\ud558\uace0 \uacc4\uc218\ud560 \uc218 \uc788\ub3c4\ub85d \ub18d\ucd95\ud560 \uc218 \uc788\ub2e4. \ud604\uc7ac\uae4c\uc9c0 \uc774 \uae30\uc220\uc740 NGS\ub098 microarray\uc640 \ub2ec\ub9ac \uc804\ud5a5\uc801 \uc784\uc0c1 \uc5f0\uad6c\uc5d0\uc11c \ub110\ub9ac \uac80\uc99d\ub418\uc9c0 \uc54a\uc558\ub2e4.<\/p>\n

cfDNA\uac00 \uac00\uc838\uc62c \uc7a0\uc7ac\uc801 \uc601\ud5a5\uc740 \ubb34\uc5c7\uc778\uac00?<\/h2>\n

\uace0\uc704\ud5d8 \ub610\ub294 \uc911\uac04\uc704\ud5d8 \uc784\uc2e0\uc5d0\uc11c\ub9cc \uc81c\uacf5\ub418\ub294 \uc120\ubcc4\uac80\uc0ac\ub85c\uc11c, cfDNA \uac80\uc0ac\ub294 \uc774\ubbf8 \uc5ec\uc131\ub4e4\uc758 \uc120\ud0dd\uc5d0 \ubcc0\ud654\ub97c \uc77c\uc73c\ud0a4\uace0, \uc720\uc0b0 \uc704\ud5d8\uacfc \uad00\ub828\ub41c \uc808\ucc28 \ubc0f \ubd88\uc548\uc744 \uc904\uc774\uace0 \uc788\ub2e4. \ud64d\ucf69\uc5d0\uc11c \uc784\uc2e0\ubd80\ub97c \ub300\uc0c1\uc73c\ub85c \ud55c \uc5f0\uad6c[11]\uc5d0\uc11c\ub294 cfDNA \uac80\uc0ac\uac00 \ub3c4\uc785\ub41c \uc774\ud6c4 \uce68\uc2b5\uc801 \uac80\uc0ac\uc758 \ube44\uc728\uc774 \ud06c\uac8c \uac10\uc18c\ud55c \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\ub2e4. \uc0b0\ubd80\uc778\uacfc \uc758\uc0ac\uc5d0\uac8c \ub610 \ub2e4\ub978 \ube44\uce68\uc2b5\uc801 \uac80\uc0ac \ubc29\ubc95\uc744 \uc81c\uacf5\ud560 \uc218 \uc788\ub294 \uc5f0\uad6c\uc2e4\uc740, \uc784\uc2e0\ubd80\uac00 \ubcf4\ub2e4 \uba85\ud655\ud558\uac8c \uc815\ubcf4\ub97c \uae30\ubc18\uc73c\ub85c \uacb0\uc815\uc744 \ub0b4\ub9b4 \uc218 \uc788\ub3c4\ub85d \ub3d5\uace0 \uad81\uadf9\uc801\uc73c\ub85c \ubd88\ud544\uc694\ud55c \uce68\uc2b5\uc801 \uc808\ucc28\ub97c \ud53c\ud560 \uc218 \uc788\uac8c \ud55c\ub2e4.<\/p>\n

References:<\/em><\/p>\n

[1]<\/a> Malone, D.F., et al., (2005). First-Trimester or Second-Trimester Screening, or Both, for Down’s Syndrome. The New England Journal of Medicine. 353(19), pp.2001-2011.<\/p>\n

[2]<\/a>\u00a0Li, S.W., et al., (2015). The assessment of combined first trimester screening in women of advanced maternal age in an Asian cohort.\u00a0Singapore medical journal,\u00a056(1), pp.47\u201352.<\/p>\n

[3]\u00a0<\/a>Kotsopoulou, I., et al., (2015). Non-invasive prenatal testing (NIPT): limitations on the way to become diagnosis,\u00a0Diagnosis,\u00a02(3), pp.141-158.<\/p>\n

[4]<\/a>\u00a0Taglauer, E.S., et al., (2014). Review: cell-free fetal DNA in the maternal circulation as an indication of placental health and disease.\u00a0Placenta,\u00a035 Suppl(Suppl), S64\u2013S68.<\/p>\n

[5]<\/a> Wataganara, T., et al., (2004). Cell-free fetal DNA levels in maternal plasma after elective first-trimester termination of pregnancy. Fertility and Sterility,\u00a081(3), pp.638-644.<\/p>\n

[6]\u00a0<\/a>Swanson, A., et al.,\u00a0(2013). Non-invasive Prenatal Testing: Technologies, Clinical Assays and Implementation Strategies for Women’s Healthcare Practitioners.\u00a0Current genetic medicine reports,\u00a01(2), pp.113\u2013121.<\/p>\n

[7]\u00a0<\/a>Norwitz, E.R., & Levy, B.(2013). Noninvasive prenatal testing: the future is now.\u00a0Reviews in obstetrics & gynecology,\u00a06(2), pp.48\u201362.<\/p>\n

[8]\u00a0<\/a>Kim, S., et L.,\u00a0(2016). Comparison of two high-throughput semiconductor chip sequencing platforms in noninvasive prenatal testing for Down syndrome in early pregnancy.\u00a0BMC medical genomics,\u00a09(1),\u00a0pp.22.<\/p>\n

[9]<\/a> Juneau, K., et al., (2014). Microarray-Based Cell-Free DNA Analysis Improved Noninvasive Prenatal Testing. Fetal Diagnosis and Therapy, 36, pp.282-286.<\/p>\n

[10]<\/a> Dahl, F., et al., (2018). Imaging single DNA molecules for high precision NIPT. Scientific Reports, 8, 4549.<\/p>\n

[11]<\/a> Cheng YKY., eet al., (2018).\u00a0\u00a0Women\u2019s preference for non-invasive prenatal DNA testing versus chromosomal microarray after screening for Down syndrome: a prospective study. BJOG, 125, pp.451\u2013459.<\/p>\n

\n

\uc774 \uae00\uc740 2018\ub144 \ud0dc\uad6d \ubc29\ucf55 NIPT Forum Asia\uc5d0\uc11c \ubc1c\ud45c\ub41c \u201cEvolution of clinically relevant NIPT technology\u201d\uc640 \u201cUpdated evidence and implementation models of cfDNA testing\u201d\ub97c \uae30\ubc18\uc73c\ub85c \uc791\uc131\ub418\uc5c8\ub2e4.<\/em><\/p>\n

\n","protected":false},"excerpt":{"rendered":"

\uc0b0\uc804 \uc9c4\ucc30\uc740 \ub300\uccb4\ub85c \uae30\uc05c \uc790\ub9ac\uc774\uc9c0\ub9cc, \ubaa8\ub4e0 \uc784\uc2e0\uc5d0\ub294 \uc5fc\uc0c9\uccb4 \uc774\uc0c1 \uc704\ud5d8\uc774 \ub530\ub974\uae30 \ub54c\ubb38\uc5d0 \ub9ce\uc740 \uc5ec\uc131\ub4e4\uc774 \uc5ec\uc804\ud788 \ubd88\uc548\uc744 \ub290\ub07c\uae30\ub3c4 \ud55c\ub2e4. \ub2e4\ud589\ud788 \ube44-\uce68\uc2b5\uc801 \uc0b0\uc804 \uac80\uc0ac(NIPT) \uae30\uc220\uc774 \ubc1c\uc804\ud558\uba74\uc11c \uac80\uc0ac \uacfc\uc815\uc740 \uadf8 \uc5b4\ub290 \ub54c\ubcf4\ub2e4 \ub354 \ud3b8\ub9ac\ud558\uace0 \uc2e0\ub8b0\ud560 \uc218 \uc788\uac8c \ub418\uc5c8\ub2e4. NIPT\ub97c \uc704\ud55c cfDNA \ubd84\uc11d\uc758 \ubd80\uc0c1 1990\ub144\ub300\uc5d0 \ub3c4\uc785\ub41c \uc774\ud6c4, 1\ucc28 \uae30\ud615\uc544 \uac80\uc0ac(FTS)\ub294 \uc0b0\uc804 \uac80\uc0ac\uc5d0\uc11c \ub110\ub9ac \uc0ac\uc6a9\ub418\ub294 \ubc29\ubc95\uc774\uc5c8\ub2e4. \uc774 \ubc29\ubc95\uc740 \uc784\uc2e0 11 […]<\/p>\n","protected":false},"author":1,"featured_media":83570,"parent":0,"menu_order":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"tags":[12455,12477,12457],"pillarandcategory":[326,282,309,288],"reporter":[12479,12478],"class_list":["post-140421","acf_article","type-acf_article","status-publish","has-post-thumbnail","hentry","tag-clinical-value","tag-12477","tag-12457","pillarandcategory-sequencing","pillarandcategory-disease-area","pillarandcategory-operations","pillarandcategory-womens-health","reporter-liona-poon","reporter-tachjaree-panchalee"],"acf":[],"_links":{"self":[{"href":"https:\/\/labinsights.com\/ko\/wp-json\/wp\/v2\/acf_article\/140421","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labinsights.com\/ko\/wp-json\/wp\/v2\/acf_article"}],"about":[{"href":"https:\/\/labinsights.com\/ko\/wp-json\/wp\/v2\/types\/acf_article"}],"author":[{"embeddable":true,"href":"https:\/\/labinsights.com\/ko\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":6,"href":"https:\/\/labinsights.com\/ko\/wp-json\/wp\/v2\/acf_article\/140421\/revisions"}],"predecessor-version":[{"id":149707,"href":"https:\/\/labinsights.com\/ko\/wp-json\/wp\/v2\/acf_article\/140421\/revisions\/149707"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/labinsights.com\/ko\/wp-json\/wp\/v2\/media\/83570"}],"wp:attachment":[{"href":"https:\/\/labinsights.com\/ko\/wp-json\/wp\/v2\/media?parent=140421"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/labinsights.com\/ko\/wp-json\/wp\/v2\/tags?post=140421"},{"taxonomy":"pillarandcategory","embeddable":true,"href":"https:\/\/labinsights.com\/ko\/wp-json\/wp\/v2\/pillarandcategory?post=140421"},{"taxonomy":"reporter","embeddable":true,"href":"https:\/\/labinsights.com\/ko\/wp-json\/wp\/v2\/reporter?post=140421"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}