{"id":146332,"date":"2025-07-29T02:46:26","date_gmt":"2025-07-29T02:46:26","guid":{"rendered":"https:\/\/labinsights.com\/acf_article\/%ed%98%88%ec%95%a1-%ec%95%88%ec%a0%84-%ec%9e%ac%ea%b3%a0-%ec%95%84%ec%8b%9c%ec%95%84-%ed%83%9c%ed%8f%89%ec%96%91-%ec%a7%80%ec%97%ad-%ed%98%88%ec%95%a1%ec%9d%80%ed%96%89%ec%9d%b4-%ec%88%98%ed%98%88\/"},"modified":"2026-02-18T11:37:57","modified_gmt":"2026-02-18T11:37:57","slug":"rethinking-blood-safety-how-apac-blood-banks-can-stay-ahead-of-transfusion-risks","status":"publish","type":"acf_article","link":"https:\/\/labinsights.com\/ko\/disease-area\/blood-screening-2\/rethinking-blood-safety-how-apac-blood-banks-can-stay-ahead-of-transfusion-risks\/","title":{"rendered":"\ud608\uc561 \uc548\uc804 \uc7ac\uace0: \uc544\uc2dc\uc544 \ud0dc\ud3c9\uc591 \uc9c0\uc5ed \ud608\uc561\uc740\ud589\uc774 \uc218\ud608 \uc704\ud5d8\uc5d0 \uc120\uc81c\uc801\uc73c\ub85c \ub300\uc751\ud558\ub294 \ubc29\ubc95"},"content":{"rendered":"

\ubaa9\ucc28:<\/h2>\n
    \n
  1. \uc11c\ub860<\/a><\/li>\n
  2. \ud56d\uccb4\uc5d0\uc11c RNA\uae4c\uc9c0: \ud608\uc561 \uc120\ubcc4 \uac80\uc0ac\uc758 \uc9c4\ud654<\/a><\/li>\n
  3. \ud5cc\ud608\uc790 \ubb38\uc9c4\ud45c: \uccab \ubc88\uc9f8 \ubc29\uc5b4\uc120<\/a><\/li>\n
  4. \ud608\uccad\ud559\uc801 \uac80\uc0ac: \ub450 \ubc88\uc9f8 \uc120\ubcc4 \uac80\uc0ac<\/a><\/li>\n
  5. \ud575\uc0b0 \uac80\uc0ac: \ubd84\uc790 \uc774\uc815\ud45c<\/a><\/li>\n
  6. \ud575\uc0b0 \uac80\uc0ac\ub294 \uc911\uac04~\uace0\uc720\ud589 \uc9c0\uc5ed\uc5d0\uc11c \ud310\ub3c4\ub97c \ubc14\uafb8\ub294 \uae30\uc220\uc785\ub2c8\ub2e4<\/a><\/li>\n
  7. \ud655\uc7a5\ub418\ub294 \uc704\ud611 \ubaa9\ub85d: \ud608\uc561 \uc120\ubcc4 \uac80\uc0ac\uac00 \uacc4\uc18d \ubc1c\uc804\ud558\ub294 \uc774\uc720<\/a><\/li>\n
  8. \ubc14\uc774\ub7ec\uc2a4 \uac10\uc5fc\uc758 \uc0c8\ub85c\uc6b4 \ubb3c\uacb0<\/a><\/li>\n
  9. \uae30\uc0dd\ucda9: \ub4dc\ubb3c\uc9c0\ub9cc \uce58\uba85\uc801\uc778 \uc704\ud611<\/a><\/li>\n
  10. \uacb0\ub860<\/a><\/li>\n<\/ol>\n

    \uc11c\ub860<\/h2>\n

    \ud5cc\ud608\ub85c \ubaa8\uc778 \ubaa8\ub4e0 \ud608\uc561\uc740 \uc0dd\uba85\uc744 \uad6c\ud560 \uac00\ub2a5\uc131\uc774 \uc788\uc9c0\ub9cc, \ub3d9\uc2dc\uc5d0 \uc704\ud5d8\ub3c4 \uc218\ubc18\ud569\ub2c8\ub2e4. \uc218\ud608\uc740 \uc758\ud559\uc5d0\uc11c \uc0dd\uba85\uc744 \uad6c\ud558\ub294 \uc544\uc8fc \uc911\uc694\ud55c \uac1c\uc785 \uc911 \ud558\ub098\uc785\ub2c8\ub2e4. \uc218\ud608\uc740 \uc218\uc220, \uc678\uc0c1, \uc554 \uce58\ub8cc, \ubd84\ub9cc, \uc2ec\ud55c \ube48\ud608 \ud658\uc790\ub97c \ub3d5\uc2b5\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \ud608\uc561\uc740 \uc0dd\ubb3c\ud559\uc801 \uc81c\uc81c\uc774\ubbc0\ub85c \ud5cc\ud608\uc790\uc758 \uac74\uac15 \uc0c1\ud0dc\ubfd0 \uc544\ub2c8\ub77c \uadf8 \uc9c0\uc5ed\uc758 \uc5ed\ud559\uc801 \uc704\ud5d8\ub3c4 \ubc18\uc601\ub429\ub2c8\ub2e4. \uc804 \uc138\uacc4 \uc2dc\uc2a4\ud15c\uc774 \ubc1c\uc804\ud558\uba74\uc11c \uc218\ud608\uc740 \uc5b4\ub290 \ub54c\ubcf4\ub2e4\ub3c4 \uc548\uc804\ud574\uc84c\uc9c0\ub9cc, \uc218\ud608 \uc804\ud30c \uac10\uc5fc(Transfusion-Transmitted Infections, TTI)\uc758 \uc704\ud5d8\uc740 \uc644\uc804\ud788 \uc0ac\ub77c\uc9c4 \uac83\uc774 \uc544\ub2c8\ub77c \uad00\ub9ac\ub418\uace0 \uc788\uc744 \ubfd0\uc785\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uad00\ub9ac\ub294 \uc138 \uac00\uc9c0 \ud575\uc2ec \uc694\uc18c\uc5d0 \ub530\ub77c \ub2ec\ub77c\uc9d1\ub2c8\ub2e4. \ud5cc\ud608\uc790\ub97c \uc5bc\ub9c8\ub098 \uc2e0\uc911\ud558\uac8c \uc120\uc815\ud558\ub294\uc9c0, \ud608\uc561\uc744 \uc5bc\ub9c8\ub098 \uc5c4\uaca9\ud558\uac8c \uc120\ubcc4 \uac80\uc0ac\ud558\ub294\uc9c0, \ub2e4\uac00\uc62c \uac10\uc5fc \uc704\ud611\uc5d0 \uc5bc\ub9c8\ub098 \uc798 \ub300\ube44\ud558\uace0 \uc788\ub294\uc9c0\uc785\ub2c8\ub2e4. \uc9c0\ub09c 40\uc5ec \ub144 \ub3d9\uc548 HIV, B\ud615 \uac04\uc5fc(HBV), C\ud615 \uac04\uc5fc(HCV)\uc5d0 \ub300\ud55c \ud608\uccad \uac80\uc0ac \ub3c4\uc785\uc73c\ub85c \uc218\ud608 \uac10\uc5fc \uc704\ud5d8\uc740 \uc791\uc544\uc84c\uc2b5\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uc774\ub7ec\ud55c \uac80\uc0ac\uc5d0\ub294 \ud5cc\ud608\uc790\uac00 \uac10\uc5fc \ud6c4 \uac10\uc5fc\uc131\uc774 \uc788\ub294 \uc0c1\ud0dc\uc774\uc9c0\ub9cc \uac80\uc0ac\uc5d0\uc11c\ub294 \uc5ec\uc804\ud788 \uc74c\uc131\uc73c\ub85c \ub098\ud0c0\ub098\ub294 \uae30\uac04\uc778 ‘\uc708\ub3c4 \ud53c\ub9ac\uc5b4\ub4dc'(window period)\uac00 \uc874\uc7ac\ud569\ub2c8\ub2e4 [1]. \uc778\uad6c\uc758 \uc720\ubcd1\ub960\uc774 \ub192\uac70\ub098 \ub385\uae30\uc5f4, \uc9c0\uce74 \ubc14\uc774\ub7ec\uc2a4 \ub4f1\uc758 \ub9e4\uac1c\uccb4 \uac10\uc5fc\ubcd1\uc774 \uacc4\uc808\uc801\uc73c\ub85c \uc720\ud589\ud558\ub294 \uc9c0\uc5ed\uc5d0\uc11c\ub294 \ud2b9\ud788 \uac80\ucd9c\uc758 \uacf5\ubc31\uc774 \uc0dd\uae30\uae30 \uc27d\uc2b5\ub2c8\ub2e4 [2]. \ub530\ub77c\uc11c \ud608\uc561 \uc548\uc804\uc740 \uc5b4\ub5a4 \ud56d\ubaa9\uc744 \uc120\ubcc4 \uac80\uc0ac\ud558\ub290\ub0d0\ubfd0\ub9cc \uc544\ub2c8\ub77c, \uc0c8\ub85c \ub4f1\uc7a5\ud558\ub294 \uc704\ud611\uc5d0 \uc5bc\ub9c8\ub098 \uc2e0\uc18d\ud558\uac8c \ub300\uc751\ud558\ub290\ub0d0\uc5d0\ub3c4 \uc88c\uc6b0\ub429\ub2c8\ub2e4.<\/p>\n

    \ud56d\uccb4\uc5d0\uc11c RNA\uae4c\uc9c0: \ud608\uc561 \uc120\ubcc4 \uac80\uc0ac\uc758 \uc9c4\ud654<\/h2>\n

    \uc624\ub298\ub0a0 \uc6b0\ub9ac\uac00 \uc758\uc874\ud558\uace0 \uc788\ub294 \ud608\uc561 \uc120\ubcc4 \uac80\uc0ac \uc2dc\uc2a4\ud15c\uc740 \ud558\ub8e8\uc544\uce68\uc5d0 \ub9cc\ub4e4\uc5b4\uc9c4 \uac83\uc774 \uc544\ub2d9\ub2c8\ub2e4. \uc774 \uc2dc\uc2a4\ud15c\uc740 \uc704\uae30\ub97c \uacc4\uae30\ub85c \ub9cc\ub4e4\uc5b4\uc84c\uace0, \uacfc\ud559\uc5d0 \ub530\ub77c \uc218\uc815\ub418\uc5c8\uc73c\uba70, \uc2dc\ud589\ucc29\uc624\ub97c \ud1b5\ud574 \uac1c\uc120\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc0c8\ub85c\uc6b4 \ubcd1\uc6d0\uccb4\uac00 \ubc1c\uacac\ub420 \ub54c\ub9c8\ub2e4 \uc2dc\uc2a4\ud15c\uc758 \uc0ac\uac01\uc9c0\ub300\uac00 \ub4dc\ub7ec\ub0ac\uc2b5\ub2c8\ub2e4. \ud53c\ud574\ub97c \ubcf8 \ud658\uc790 \ubaa8\ub450\uac00 \ubb34\uc5c7\uc744 \ubc14\uafb8\uc5b4\uc57c \ud558\ub294\uc9c0 \ubcf4\uc5ec\uc8fc\ub294 \uc99d\ub840\uac00 \ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ud604\uc7ac \uc0ac\uc6a9\ud558\ub294 \uc2dc\uc2a4\ud15c\uc740 \ud5cc\ud608\uc790 \uc120\uc815 \u2192 \ud608\uccad\ud559\uc801 \uc120\ubcc4 \uac80\uc0ac \u2192 \ud575\uc0b0 \uac80\uc0ac(Nucleic Acid Testing, NAT)\ub85c \uc774\ub8e8\uc5b4\uc9c4 \uc0bc\uc911 \ubc29\uc5b4 \uc2dc\uc2a4\ud15c\uc785\ub2c8\ub2e4.<\/p>\n

    \ud5cc\ud608\uc790 \ubb38\uc9c4\ud45c: \uccab \ubc88\uc9f8 \ubc29\uc5b4\uc120<\/h2>\n

    \ud608\uc561 \uc548\uc804\uc744 \uc704\ud55c \uccab \ubc88\uc9f8 \ubcf4\ud638 \uc7a5\uce58\ub294 \ub300\ud654\ub85c \uc2dc\uc791\ub429\ub2c8\ub2e4. \ud5cc\ud608\uc790 \uc774\ub825 \ubb38\uc9c4\ud45c\ub294 \uc704\ud5d8\uc744 \ud3c9\uac00\ud558\uae30 \uc704\ud55c \uac15\ub825\ud55c \ucd5c\uc804\uc120 \ub3c4\uad6c\uc785\ub2c8\ub2e4. \ubb38\uc9c4\ud45c\ub294 \ucd5c\uadfc \uc9c8\ubcd1, \uac10\uc5fc \uc704\ud5d8\uc774 \ub2e4\ub978 \uc9c0\uc5ed\uc73c\ub85c\uc758 \uc5ec\ud589 \uc774\ub825, \ubcd1\ub825, \uace0\uc704\ud5d8 \ud589\ub3d9 \ub4f1\uc758 \uc694\uc18c\ub97c \uc120\ubcc4\ud558\uae30 \uc704\ud574 \uad6c\uc870\ud654\ub41c \uadfc\uac70 \uae30\ubc18 \uc9c8\ubb38\uc744 \uc0ac\uc6a9\ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc704\ud5d8 \uae30\ubc18 \ud3c9\uac00\ub294 \uc7a0\uc7ac\uc801\uc73c\ub85c \uac10\uc5fc \uac00\ub2a5\uc131\uc774 \uc788\ub294 \ud5cc\ud608 \ud608\uc561\uc774 \ud608\uc561 \uacf5\uae09 \uccb4\uacc4\ub85c \uc720\uc785\ub418\ub294 \uac83\uc744 \ub9c9\ub294 \ub370 \ub3c4\uc6c0\uc744 \uc8fc\uba70, \uac80\uc0ac\ub97c \ud558\uae30 \uc804\uc5d0 \ud6a8\uacfc\ub97c \ub098\ud0c0\ub0b4\ub294 \uacbd\uc6b0\uac00 \ub9ce\uc2b5\ub2c8\ub2e4. \uc798 \uc124\uacc4\ub418\uace0 \uc5c4\uaca9\ud558\uac8c \uc801\uc6a9\ub420 \uacbd\uc6b0, \uc774\ub7ec\ud55c \ubb38\uc9c4\ud45c\ub97c \ud1b5\ud574 \uace0\uc704\ud5d8 \ud5cc\ud608\uc790\uc758 \uc0c1\ub2f9 \ubd80\ubd84\uc744 \ubc30\uc81c\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uc774 \uacfc\uc815\uc740 \uc804\uc801\uc73c\ub85c \uc790\uac00 \ubcf4\uace0 \uc815\ubcf4\uc5d0 \uc758\uc874\ud558\uba70, \uc9c4\uc220\uc5d0 \uae30\ubc18\ud55c \uc5b4\ub5a4 \uc2dc\uc2a4\ud15c\ub3c4 \uc644\ubcbd\ud560 \uc218\ub294 \uc5c6\uc2b5\ub2c8\ub2e4. \ubaa8\ub4e0 \uc801\uaca9 \uae30\uc900\uc744 \ucda9\uc871\ud55c \ud5cc\ud608\uc790\ub77c \ud558\ub354\ub77c\ub3c4 \uc5ec\uc804\ud788 \ubc1c\uacac\ub418\uc9c0 \uc54a\uc740 \uac10\uc5fc\uccb4\ub97c \uac16\uace0 \uc788\uc744 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \ubca0\ud2b8\ub0a8 \ubd81\ubd80 \ub18d\ucd0c \uc9c0\uc5ed\uc5d0\uc11c\ub294 \ub300\ubd80\ubd84\uc758 \ud5cc\ud608\uc790\uac00 \ubb34\uc99d\uc0c1\uc774\uc5c8\uc74c\uc5d0\ub3c4 \uc778\uad6c\uc758 \uac70\uc758 45%\uac00 \uacfc\uac70 B\ud615 \uac04\uc5fc \ubc14\uc774\ub7ec\uc2a4(HBV)\uc5d0 \ub178\ucd9c\ub41c \uc99d\uac70\ub97c \ubcf4\uc600\uc2b5\ub2c8\ub2e4 [3]. \uc774 \uc0ac\uc2e4\uc740 \uc800\uc704\ud5d8\uc774 \ubb34\uc704\ud5d8\uc744 \uc758\ubbf8\ud558\uc9c0\ub294 \uc54a\ub294\ub2e4\ub294 \uc911\uc694\ud55c \ud55c\uacc4\ub97c \ubcf4\uc5ec \uc90d\ub2c8\ub2e4. \ud5cc\ud608\uc790 \ubb38\uc9c4\ud45c\ub294 \uc5ec\uc804\ud788 \uc911\uc694\ud55c \ud544\ud130\uc774\uc9c0\ub9cc, \ud5cc\ud608\uc790 \uc120\ubcc4 \uac80\uc0ac \uacfc\uc815\uc5d0\uc11c \ub193\uce5c \uac10\uc5fc\uc744 \ud3ec\ucc29\ud560 \uc218 \uc788\ub294 \uac15\ub825\ud55c \uc120\ubcc4 \uac80\uc0ac \ud504\ub85c\ud1a0\ucf5c\uc774 \ubc18\ub4dc\uc2dc \ub4b7\ubc1b\uce68\ub418\uc5b4\uc57c \ud569\ub2c8\ub2e4 [4].<\/p>\n

    \ud608\uccad \uac80\uc0ac: \ub450 \ubc88\uc9f8 \uc120\ubcc4 \uac80\uc0ac<\/h2>\n

    1980\ub144\ub300 \ub3c4\uc785\ub41c B\ud615 \uac04\uc5fc\uacfc HIV \ud608\uccad \uac80\uc0ac\ub294 \ud608\uc561 \uc548\uc804\uc131\uc744 \ud68d\uae30\uc801\uc73c\ub85c \ud5a5\uc0c1\uc2dc\ucf30\uc2b5\ub2c8\ub2e4. HIV, B\ud615 \uac04\uc5fc \ubc14\uc774\ub7ec\uc2a4(HBV), C\ud615 \uac04\uc5fc \ubc14\uc774\ub7ec\uc2a4(HCV), \ub9e4\ub3c5\uc5d0 \ub300\ud55c \ud56d\uccb4\uc640 \ud45c\uba74 \ud56d\uc6d0\uc744 \uac80\ucd9c\ud560 \uc218 \uc788\uac8c \ub418\uba74\uc11c \uc804 \uc138\uacc4\uc801\uc73c\ub85c \ubaa8\ub4e0 \ud5cc\ud608\uc758 \uc548\uc804\uc131\uc774 \ub192\uc544\uc84c\uc2b5\ub2c8\ub2e4. \ud2b9\ud788 \ub9e4\ub3c5 \uc120\ubcc4 \uac80\uc0ac\ub294 \uc218\uc2ed \ub144\uac04 \ud5cc\ud608\uc790 \ud504\ub85c\ud1a0\ucf5c\uc758 \uc77c\ubd80\uc600\uc2b5\ub2c8\ub2e4. \uc885\uc885 ‘\uc624\ub798\ub41c’ \ud639\uc740 \uad6c\uc2dd \uac80\uc0ac\ub85c \uc5ec\uaca8\uc9c0\uc9c0\ub9cc, \uadf8 \ud0c0\ub2f9\uc131\uc740 \uc624\ud788\ub824 \ucee4\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc804 \uc138\uacc4 \uc790\ub8cc\uc5d0 \ub530\ub974\uba74 \ub9e4\ub3c5 \uac10\uc5fc\uc774 \ub2e4\uc2dc \uc99d\uac00\ud558\ub294 \ucd94\uc138\ub97c \ubcf4\uc774\uace0 \uc788\uc73c\uba70, \uc774\uc5d0 \ub530\ub77c \uc9c0\uc18d\uc801\uc778 \uc120\ubcc4 \uac80\uc0ac\uac00 \ud544\uc218\uc801\uc785\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4 \ud0dc\uad6d\uc758 \uacbd\uc6b0 \ud5cc\ud608\uc790 \uc911 \ub9e4\ub3c5 \ud608\uccad \uc720\ubcd1\ub960\uc740 \uc5ec\uc804\ud788 0.42% \uc218\uc900\uc774\uba70, \ucd5c\ucd08 \ud5cc\ud608\uc790\uc640 \ub0a8\uc131 \ud5cc\ud608\uc790\uc5d0\uc11c \ub354 \ub192\uc740 \ube44\uc728\uc744 \ubcf4\uc785\ub2c8\ub2e4 [5,6]. \ud608\uccad \uc120\ubcc4 \uac80\uc0ac\uc758 \ubc1c\uc804\uc740 \uc804 \uc138\uacc4\uc801\uc73c\ub85c \uc218\ud608 \uc804\ud30c \uac10\uc5fc(Transfusion-Transmitted Infections, TTI)\uc744 \uc0c1\ub2f9\ud788 \uac10\uc18c\uc2dc\ucf30\uc2b5\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uc774\ub7ec\ud55c \uac80\uc0ac\uc5d0\ub294 ‘\uc708\ub3c4 \ud53c\ub9ac\uc5b4\ub4dc’\ub77c\ub294 \ud55c\uacc4\uac00 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \uae30\uac04\uc5d0 \ud5cc\ud608\ud55c \ud608\uc561\uc740 \uac10\uc5fc\uccb4\uac00 \uc874\uc7ac\ud558\ub354\ub77c\ub3c4 \uac80\ucd9c\ub418\uc9c0 \uc54a\uc744 \uc218 \uc788\uc5b4 \uc801\uc9c0\ub9cc TTI\uc758 \uc704\ud5d8\uc774 \ub0a8\uc544 \uc788\uac8c \ub429\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ud55c\uacc4\ub294 \ud2b9\ud788 \uc9c8\ubcd1 \uc720\ubcd1\ub960\uc774 \ub192\uac70\ub098 \uc5ed\ud559\uc801 \uc704\ud611\uc774 \uc9c4\ud654\ud558\ub294 \uc9c0\uc5ed\uc5d0\uc11c \uac10\uc5fc \ucd08\uae30\uc5d0 \ub354 \uc77c\ucc0d \uac80\ucd9c\ud560 \uc218 \uc788\ub294 \ubcf4\uc644\uc801 \uae30\uc220\uc758 \ud544\uc694\uc131\uc744 \uc798 \ubcf4\uc5ec \uc90d\ub2c8\ub2e4.<\/p>\n

    \ud575\uc0b0 \uac80\uc0ac: \ubd84\uc790 \uc774\uc815\ud45c<\/h2>\n

    1990\ub144\ub300 \ud6c4\ubc18 \ub3c4\uc785\ub41c \uc774\ud6c4 \ud575\uc0b0 \uac80\uc0ac(Nucleic Acid Testing, NAT)\ub294 \uc774\ub97c \ub4b7\ubc1b\uce68\ud560 \uc778\ud504\ub77c\ub97c \uac16\ucd98 \uad6d\uac00\uc5d0\uc11c \ud45c\uc900 \uac80\uc0ac\ubc95\uc73c\ub85c \uc790\ub9ac \uc7a1\uc558\uc2b5\ub2c8\ub2e4. \uc544\uc2dc\uc544 \ud0dc\ud3c9\uc591 \uc9c0\uc5ed \uc804\ubc18\uc5d0\uc11c NAT\uc758 \ub3c4\uc785\uc740 \uc77c\uad00\uc131\uc774 \uc5c6\uc5b4 \ub9ce\uc740 \ud608\uc561 \uc11c\ube44\uc2a4 \uae30\uad00\uc774 \uc5ec\uc804\ud788 \ud608\uccad \uac80\uc0ac\uc5d0\ub9cc \uc758\uc874\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uadf8 \uacb0\uacfc \ud2b9\ud788 HIV, HBV, HCV \ub4f1\uc758 \uc218\ud608 \uc804\ud30c \uac10\uc5fc\uc758 \uc720\ubcd1\ub960\uc774 \ub192\uac70\ub098, \ub2e4\ub978 \uc0c8\ub85c\uc6b4 \uac10\uc5fc\uc774 \uc99d\uac00\ud558\uace0 \uc788\ub294 \uad6d\uac00\uc5d0\uc11c\ub294 \uc548\uc804\uc131\uc5d0 \uc911\ub300\ud55c \uacf5\ubc31\uc774 \ub0a8\uac8c \ub429\ub2c8\ub2e4 [7].<\/p>\n

    \ud575\uc0b0 \uac80\uc0ac\ub294 \uc911\uac04~\uace0\uc720\ud589 \uc9c0\uc5ed\uc5d0\uc11c \ud310\ub3c4\ub97c \ubc14\uafb8\ub294 \uae30\uc220\uc785\ub2c8\ub2e4<\/h2>\n

    \ud608\uc561 \uc120\ubcc4 \uac80\uc0ac \uacfc\uc815\uc758 \uac01 \ub2e8\uacc4\ub294 \ubc14\ub85c \uc55e \ub2e8\uacc4\uc5d0\uc11c \ub193\uce5c \ubd80\ubd84\uc744 \ubcf4\uc644\ud558\uae30 \uc704\ud574 \uc874\uc7ac\ud569\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uccab \ubc88\uc9f8 \ub2e8\uacc4(\ud5cc\ud608\uc790 \ubb38\uc9c4\ud45c)\ub294 \ucd5c\uadfc \uac10\uc5fc\uc774\ub098 \ubb34\uc99d\uc0c1 \uac10\uc5fc\uc744 \ub193\uce60 \uc218 \uc788\uace0, \ub450 \ubc88\uc9f8 \ub2e8\uacc4(\ud608\uccad \uac80\uc0ac)\ub294 \uc708\ub3c4 \ud53c\ub9ac\uc5b4\ub4dc\ub77c\ub294 \ud55c\uacc4\uac00 \uc788\uc73c\ubbc0\ub85c \uc138 \ubc88\uc9f8 \ub2e8\uacc4(NAT)\uc758 \uc5ed\ud560\uc774 \uc911\uc694\ud574\uc9d1\ub2c8\ub2e4. \ubc14\uc774\ub7ec\uc2a4\uc758 RNA \ub610\ub294 DNA\ub97c \uc9c1\uc811 \uac80\ucd9c\ud568\uc73c\ub85c\uc368 NAT\ub294 \ud5cc\ud608\uc790\uac00 \uc774\ubbf8 \uac10\uc5fc\ub418\uc5c8\uc9c0\ub9cc \uae30\uc874 \ud608\uccad \uac80\uc0ac\uc5d0\uc11c\ub294 \uc74c\uc131\uc73c\ub85c \ub098\ud0c0\ub098\ub294 \uba70\uce60\uc5d0\uc11c \uba87 \uc8fc\uae4c\uc9c0\uc758 \uc9c4\ub2e8 \uc708\ub3c4 \ud53c\ub9ac\uc5b4\ub4dc\ub97c \uc5c6\uc560 \uc90d\ub2c8\ub2e4. \uc774\ub97c \ud1b5\ud574 NAT\ub294 \ud2b9\ud788 HBV, HCV, HIV \ub4f1\uc758 TTI\ub97c \uc608\ubc29\ud558\ub294 \ub370 \ud575\uc2ec\uc801\uc778 \ub3c4\uad6c\uac00 \ub418\uc5c8\uc2b5\ub2c8\ub2e4. NAT vs. \ud608\uccad \uac80\uc0ac:<\/strong> HIV<\/strong> \uac10\uc5fc \ud6c4 \uc708\ub3c4 \ud53c\ub9ac\uc5b4\ub4dc \uc911\uc559\uac12\uc740 \uc57d 18\uc77c \uc815\ub3c4\uc774\uba70, \uc77c\ubc18\uc801\uc73c\ub85c 10~24\uc77c\uc785\ub2c8\ub2e4 [8]. RNA \ubd84\uc11d\ubc95\uc758 \ubbfc\uac10\ub3c4\uc5d0 \ub530\ub77c HIV \uc804\ud30c \ud6c4 \uc774\ub974\uba74 \uc57d 5~10\uc77c \uc2dc\uc810\ubd80\ud130 RNA\uac00 \uac80\ucd9c\ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4 [9]. HCV<\/strong> \ud56d-HCV \uac80\uc0ac\ub294 HCV\uc5d0 \ub178\ucd9c\ub41c \ub4a4 HCV \ud56d\uccb4\uac00 \uac80\ucd9c\ub418\uae30\uae4c\uc9c0 \uc57d 8~11\uc8fc \uc815\ub3c4\uc758 \uc708\ub3c4 \ud53c\ub9ac\uc5b4\ub4dc\uac00 \uc788\uc2b5\ub2c8\ub2e4. HCV RNA\ub294 HCV \ub178\ucd9c \ud6c4 \uc57d 1~2\uc8fc \ub4a4\ubd80\ud130 \uac80\ucd9c\ub429\ub2c8\ub2e4 [10]. HBV <\/strong>HBV DNA\ub294 \ucd08\uae30 2\uc8fc \ub3d9\uc548\uc5d0\ub294 \uc720\uc77c\ud558\uac8c \uac80\ucd9c \uac00\ub2a5\ud55c \ub9c8\ucee4\uc77c \uc218 \uc788\uc73c\uba70, HBsAg\ub294 \ub178\ucd9c \ud6c4 2~10\uc8fc\uac04 \ud608\uccad\uc5d0\uc11c \ub098\ud0c0\ub098\uba70 \uc774\ub294 \uc99d\uc0c1 \ubc1c\ud604\uacfc \uc544\ubbf8\ub178 \uc804\uc774 \ud6a8\uc18c \uc0c1\uc2b9\ubcf4\ub2e4 \uc120\ud589\ub429\ub2c8\ub2e4 [11,12]. 2005\ub144 NAT\ub97c \ub3c4\uc785\ud55c \uc774\ud6c4 \ud55c\uad6d\uc5d0\uc11c\ub294 HCV \uc804\ud30c\uc758 \uc794\uc5ec \uc704\ud5d8\uc774 \ud5cc\ud608 100\ub9cc \uac74\ub2f9 \uc57d 0.27\uac74 \uc218\uc900\uc73c\ub85c \uc904\uc5c8\uc2b5\ub2c8\ub2e4 [13]. \ubca0\ud2b8\ub0a8\uc5d0\uc11c\ub294 \ud608\uc561 \uc13c\ud130 \uc804\ubc18\uc5d0\uc11c HBV \ud45c\uba74 \ud56d\uc6d0(HBsAg) \uc120\ubcc4 \uac80\uc0ac\uac00 \ud45c\uc900 \uac80\uc0ac\ub85c \uc2dc\ud589\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ud558\uc9c0\ub9cc \uc5f0\uad6c \uacb0\uacfc HBsAg \uc74c\uc131 \ud5cc\ud608\uc790 \uc911 0.3%\uc5d0\uc11c \uc5ec\uc804\ud788 HBV DNA\uac00 \uac80\ucd9c\ub418\uc5b4 B\ud615 \uac04\uc5fc \uc7a0\uc7ac \uac10\uc5fc(Occult Hepatitis B Infection, OBI)\uc774 \uc874\uc7ac\ud568\uc744 \ubcf4\uc5ec\uc8fc\uc5c8\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c OBI \uc0ac\ub840\ub294 \ud608\uccad \uac80\uc0ac\ub85c\ub294 \uac80\ucd9c\ub418\uc9c0 \uc54a\uc73c\uba70 NAT\ub97c \ud1b5\ud574\uc11c\ub9cc \ud655\uc778\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4 [14].<\/p>\n

    \ud655\uc7a5\ub418\ub294 \uc704\ud611 \ubaa9\ub85d: \ud608\uc561 \uc120\ubcc4 \uac80\uc0ac\uac00 \uacc4\uc18d \ubc1c\uc804\ud558\ub294 \uc774\uc720<\/h2>\n

    \ub300\ubd80\ubd84\uc758 \ud608\uc561 \uc548\uc804 \uc2dc\uc2a4\ud15c\uc740 HIV, HBV, HCV, \ub9e4\ub3c5\uc774\ub77c\ub294 \ub124 \uac00\uc9c0 \ubcd1\uc6d0\uccb4\ub97c \uc911\uc2ec\uc73c\ub85c \uad6c\ucd95\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uc774 \ubaa9\ub85d\uc740 \ub354 \uc774\uc0c1 TTI \uc704\ud5d8\uc758 \uc2e4\uc81c \ubc94\uc704\ub97c \uc815\ud655\ud788 \ubc18\uc601\ud558\uc9c0 \ubabb\ud569\ub2c8\ub2e4. \ud2b9\ud788 \uae30\ud6c4, \uc778\uad6c \uc774\ub3d9, \ubc1c\ubcd1 \ube48\ub3c4 \ub4f1\uc758 \uc694\uc778\uc774 \uc5ed\ud559 \uc591\uc0c1\uc744 \uc7ac\ud3b8\ud558\uace0 \uc788\ub294 \uc544\uc2dc\uc544 \ud0dc\ud3c9\uc591 \uc9c0\uc5ed\uc5d0\uc11c\ub294 \ub354\uc6b1 \uadf8\ub7ec\ud569\ub2c8\ub2e4. \ub385\uae30: \ub192\uc740 \uc720\ubcd1\ub960, \ub0ae\uc740 \uac00\uc2dc\uc131<\/strong><\/em> \ub385\uae30 \uc790\uccb4\ub294 \uc0c8\ub85c\uc6b4 \uc9c8\ud658\uc774 \uc544\ub2c8\uc9c0\ub9cc, \uc218\ud608 \uad00\ub828 \uc704\ud5d8\uc131\uc740 \uc810\uc810 \ubb34\uc2dc\ud558\uae30 \uc5b4\ub824\uc6b4 \uc218\uc900\uc774 \ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc544\uc2dc\uc544 \ud0dc\ud3c9\uc591\uc758 \ud48d\ud1a0\ubcd1 \uad6d\uac00 \uc804\ubc18\uc5d0\uc11c \ubc14\uc774\ub7ec\uc2a4\uac00 \uad11\ubc94\uc704\ud558\uace0 \uc870\uc6a9\ud788 \ud37c\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ub385\uae30 \uac10\uc5fc \uc0ac\ub840\uc758 \ucd5c\ub300 87%\ub294 \ubb34\uc99d\uc0c1\uc73c\ub85c \ub098\ud0c0\ub0a9\ub2c8\ub2e4. \uc774 \ub54c\ubb38\uc5d0 \ud5cc\ud608\uc790 \uc774\ub825 \ubb38\uc9c4\ud45c\ub9cc\uc73c\ub85c\ub294 \uc804\ud30c \uc704\ud5d8\uc744 \ud30c\uc545\ud558\uae30 \uc5b4\ub824\uc6b8 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ubc14\uc774\ub7ec\uc2a4 \ud608\uc99d\uc740 \ucd5c\ub300 9\uc77c\uac04 \uc9c0\uc18d\ub418\uba70, \uc720\ud589 \uc2dc\uae30\uc5d0\ub294 \ud5cc\ud608 \uc801\uaca9 \ud310\uc815\uc744 \ubc1b\uc740 \ud5cc\ud608\uc790\ub4e4\uc5d0\uc11c RNA\uac00 \uac80\ucd9c\ub418\uc5c8\uc2b5\ub2c8\ub2e4 [2]. \ubca0\ud2b8\ub0a8\uc5d0\uc11c\ub294 \ud5cc\ud608\uc790 \ud608\uc561 \uac80\uccb4\uc758 \uc57d 0.3%\uc5d0\uc11c \ub385\uae30 RNA\uac00 \uac80\ucd9c\ub418\uc5c8\uc73c\ub098 \uce58\ucfe4\uad6c\ub2c8\uc57c\ub098 \uc9c0\uce74 \ubc14\uc774\ub7ec\uc2a4\uac00 \ubc1c\uacac\ub41c \uc0ac\ub840\ub294 \uc5c6\uc5c8\uc2b5\ub2c8\ub2e4. \ud0dc\uad6d\uc5d0\uc11c\ub294 \uac80\uccb4\uc758 0.07%\uc5d0\uc11c \ub385\uae30, 0.03%\uc5d0\uc11c \uce58\ucfe4\uad6c\ub2c8\uc57c, 0.02%\uc5d0\uc11c \uc9c0\uce74 \ubc14\uc774\ub7ec\uc2a4\uac00 \uac80\ucd9c\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ud5cc\ud608\uc790\uc5d0\uc11c \ubc14\uc774\ub7ec\uc2a4 \ud608\uc99d\uc758 \uc804\ubc18\uc801\uc778 \uc720\ubcd1\ub960\uc740 \ub0ae\uc558\uc9c0\ub9cc, \ubb34\uc99d\uc0c1 \ud5cc\ud608\uc790\uc5d0\uac8c\uc11c\ub3c4 \ubc14\uc774\ub7ec\uc2a4 \ud608\uc99d\uc774 \uce21\uc815 \uac00\ub2a5\ud55c \uc218\uc900\uc73c\ub85c \uc874\uc7ac\ud55c\ub2e4\ub294 \uc810\uc740 \ub9e4\uc6b0 \uc911\uc694\ud55c \uc2dc\uc0ac\uc810\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ubc1c\uacac\uc740 \uc218\ud608 \uc804\ud30c \uac10\uc5fc\uc758 \uc7a0\uc7ac\uc801 \uc704\ud5d8\uc131\uc744 \ubd80\uac01\uc2dc\ud0a4\uba70, \ud2b9\ud788 \ub385\uae30 \ud48d\ud1a0\ubcd1 \uc9c0\uc5ed\uc5d0\uc11c\ub294 \ud5cc\ud608\uc790\uc5d0 \ub300\ud55c \uc77c\uc0c1\uc801\uc778 \uc120\ubcc4 \uac80\uc0ac \uc2dc\ud589\uc758 \ud544\uc694\uc131\uc744 \ub4b7\ubc1b\uce68\ud569\ub2c8\ub2e4 [15]. \ub385\uae30 \uc720\ud589\uae30\uc5d0\ub294 \ud56d\uccb4 \uae30\ubc18 \uac80\uc0ac\ub85c\ub294 \ucd08\uae30 \ub2e8\uacc4 \uac10\uc5fc\uc744 \ub193\uce58\ub294 \uacbd\uc6b0\uac00 \ube48\ubc88\ud55c \ubc18\uba74, \ubc14\uc774\ub7ec\uc2a4 RNA\ub97c \uac80\ucd9c\ud558\ub294 NAT\ub294 \ud5cc\ud608\uc790 \uc120\ubcc4 \uac80\uc0ac\uc5d0 \uac00\uc7a5 \uc801\uc808\ud55c \ubc29\ubc95\uc73c\ub85c \uc5ec\uaca8\uc9c0\uba70 \uc218\ud608 \uad00\ub828 \uc804\ud30c\ub97c \ud06c\uac8c \uc904\uc77c \uc218 \uc788\uc2b5\ub2c8\ub2e4 [2]. \ubb34\uc99d\uc0c1 \ud5cc\ud608\uc790\ub85c\ubd80\ud130 \uc720\ub798\ud55c \uc218\ud608 \uc804\ud30c \ub385\uae30 \uc99d\ub840\ub294 \ud64d\ucf69, \uc2f1\uac00\ud3ec\ub974, \ube0c\ub77c\uc9c8, \ud478\uc5d0\ub974\ud1a0\ub9ac\ucf54\uc5d0\uc11c \ubcf4\uace0\ub41c \ubc14 \uc788\uc2b5\ub2c8\ub2e4 [2]. \uadf8\ub7fc\uc5d0\ub3c4 \uc774\ub7ec\ud55c \uc9c0\uc5ed\uc5d0\uc11c \ub385\uae30 RNA\uc5d0 \ub300\ud55c \uc77c\uc0c1\uc801\uc778 \uc120\ubcc4 \uac80\uc0ac\ub294 \ub110\ub9ac \uc2dc\ud589\ub418\uc9c0 \uc54a\uace0 \uc788\uc73c\uba70, \ud2b9\ud788 \uc720\ud589 \uc2dc\uae30\uc5d0\ub294 \ud604\uc7ac\uc758 \uc548\uc804 \ud504\ub85c\ud1a0\ucf5c\uc5d0 \uc7a0\uc7ac\uc801\uc778 \uacf5\ubc31\uc744 \ucd08\ub798\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc9c0\uce74 \ubc14\uc774\ub7ec\uc2a4: \uc870\uc6a9\ud558\uc9c0\ub9cc \uc2e4\uc7ac\ud558\ub294 \uc704\ud5d8<\/strong><\/em> \uc9c0\uce74 \ubc14\uc774\ub7ec\uc2a4\uc758 \uc218\ud608 \uc704\ud5d8\uc131\uc740 2015~2016\ub144 \ubbf8\uc8fc \uc9c0\uc5ed \uc720\ud589 \ub3d9\uc548 \uba85\ubc31\ud574\uc84c\uc2b5\ub2c8\ub2e4. \ud478\uc5d0\ub974\ud1a0\ub9ac\ucf54\uc5d0\uc11c\ub294 \uc720\ud589\uc774 \ud65c\ubc1c\ud558\ub358 \uc2dc\uae30\uc5d0 \ud5cc\ud608 \ud608\uc561\uc758 1% \uc774\uc0c1\uc5d0\uc11c \uc9c0\uce74 \ubc14\uc774\ub7ec\uc2a4 RNA\uac00 \uac80\ucd9c\ub418\uc5c8\uc73c\uba70, \ubaa8\ub450 \ubb34\uc99d\uc0c1 \ud5cc\ud608\uc790\uc758 \ud608\uc561\uc774\uc5c8\uc2b5\ub2c8\ub2e4. \ube0c\ub77c\uc9c8\uc5d0\uc11c\ub294 \uba74\uc5ed \uc800\ud558 \uc218\ud608\uc790\uc5d0\uc11c \uc9c0\uce74 \ubc14\uc774\ub7ec\uc2a4 \uc218\ud608 \uc804\ud30c \uc99d\ub840\uac00 \ucd5c\uc18c \ud55c \uac74 \ubcf4\uace0\ub418\uc5c8\uc2b5\ub2c8\ub2e4 [13]. \uc9c0\uce74 \ubc14\uc774\ub7ec\uc2a4\uc640 \ub385\uae30\ub294 \ub611\uac19\uc774 \ud754\ud55c \ubaa8\uae30\ub97c \ub9e4\uac1c\uccb4\ub85c \ud558\uc9c0\ub9cc, \ud608\uc561 \uc11c\ube44\uc2a4\uc5d0\uc11c\uc758 \uc8fc\uc694 \uc6b0\ub824 \uc0ac\ud56d\uc740 \uc9c0\uc18d\uc801\uc778 \uc804\ud30c\uac00 \uc544\ub2c8\ub77c \uc720\ud589 \uc2dc\uae30\uc758 \uc218\ud608 \uc704\ud5d8 \uac00\ub2a5\uc131\uc785\ub2c8\ub2e4. \uadf8 \uacb0\uacfc \ud604\uc7ac \ub300\ubd80\ubd84\uc758 \uaddc\uc81c \uae30\uad00\uc740 \ub354 \uc774\uc0c1 \uc9c0\uce74 \ubc14\uc774\ub7ec\uc2a4\uc5d0 \ub300\ud55c \ubcf4\ud3b8\uc801\uc778 \uac80\uc0ac\ub97c \uad8c\uace0\ud558\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4. \ub300\uc2e0 \uc720\ud589 \uc2dc\uae30\uc5d0 \ud55c\uc815\ud574 \ud45c\uc801 NAT \uc120\ubcc4 \uac80\uc0ac\ub97c \uc2dc\ud589\ud558\ub294 \uac83\uc774 \ub354 \uc2e4\uc6a9\uc801\uc774\uace0 \uc704\ud5d8\uc5d0 \uae30\ubc18\ud55c \uc811\uadfc\ubc95\uc73c\ub85c \uac04\uc8fc\ub429\ub2c8\ub2e4. \uc544\uc2dc\uc544 \ud0dc\ud3c9\uc591 \uc9c0\uc5ed\uc5d0\uc11c\ub294 \ud604\uc7ac \uc9c0\uce74 \ubc14\uc774\ub7ec\uc2a4\uc5d0 \ub300\ud55c \uc77c\uc0c1\uc801\uc778 NAT \uc120\ubcc4 \uac80\uc0ac\uac00 \uc2dc\ud589\ub418\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4 [7]. \ub2e4\ub9cc \uc601\ud5a5\uc744 \ubc1b\ub294 \uc9c0\uc5ed\uc5d0\uc11c\ub294 \uc720\ud589\uc5d0 \ub300\uc751\ud558\ub294 \ud504\ub85c\ud1a0\ucf5c\uc774 \uc704\ud5d8\uc744 \ub354 \ud6a8\uc728\uc801\uc73c\ub85c \uad00\ub9ac\ud558\ub294 \ubc29\ubc95\uc774 \ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

    \ubc14\uc774\ub7ec\uc2a4 \uac10\uc5fc\uc758 \uc0c8\ub85c\uc6b4 \ubb3c\uacb0<\/h2>\n

    2002\ub144~2013\ub144\uc5d0 \ubbf8\uad6d\uc5d0\uc11c\ub294 \ud65c\ubc1c\ud55c \uc9c0\uc5ed \ub0b4 \uc804\ud30c\uac00 \ubc1c\uc0dd\ud558\ub358 \uc2dc\uae30\uc5d0 \ud55c\uc815\ud558\uc5ec \uc6e8\uc2a4\ud2b8\ub098\uc77c \ubc14\uc774\ub7ec\uc2a4(West Nile Virus, WNV)\uac00 \uc218\ud608\uc744 \ud1b5\ud574 \uc804\ud30c\ub41c \uc0ac\ub840\uac00 30\uac74 \uc774\uc0c1 \ubcf4\uace0\ub418\uc5c8\uc2b5\ub2c8\ub2e4 [13]. \ubbf8\uad6d\uc740 \uc774\uc5d0 \ub300\uc751\ud558\uc5ec \uacc4\uc808\ubcc4 NAT \uc120\ubcc4 \uac80\uc0ac\ub97c \ub3c4\uc785\ud588\uace0, \uadf8 \uacb0\uacfc WNV \uad00\ub828 TTI\uac00 \uc0c1\ub2f9\ud788 \uac10\uc18c\ud588\uc2b5\ub2c8\ub2e4 [16]. \ub300\ubd80\ubd84\uc758 \uc544\uc2dc\uc544 \ud0dc\ud3c9\uc591 \uc9c0\uc5ed\uc5d0\uc11c WNV\uac00 \ud48d\ud1a0\ubcd1\uc774 \uc544\ub2c8\ub354\ub77c\ub3c4 \uc774 \uc608\uc2dc\ub294 \uc704\ud5d8 \uc815\ubcf4 \uae30\ubc18\uc73c\ub85c \uc124\uacc4\ub41c \uc720\uc5f0\ud55c \uc120\ubcc4 \uac80\uc0ac \uc804\ub7b5\uc758 \uc911\uc694\uc131\uc744 \uc798 \ubcf4\uc5ec \uc90d\ub2c8\ub2e4. \uc0c8\ub85c\uc6b4 \ubcd1\uc6d0\uccb4\uac00 \ub4f1\uc7a5\ud558\uac70\ub098, \uae30\ud6c4 \ubcc0\ud654\uc640 \ub9e4\uac1c\uccb4 \ubd84\ud3ec \ubcc0\ud654\ub85c \uae30\uc874 \ubcd1\uc6d0\uccb4\uc758 \uc720\ud589 \ubc94\uc704\uac00 \ud655\uc7a5\ub428\uc5d0 \ub530\ub77c \uc9c0\uc5ed\ubcc4 \uc5ed\ud559 \uc815\ubcf4\ub97c \uae30\ubc18\uc73c\ub85c \ud55c \ud45c\uc801 \uac80\uc0ac\ub294 \uc2dc\uc2a4\ud15c\uc5d0 \uacfc\ub3c4\ud55c \ubd80\ub2f4\uc744 \uc8fc\uc9c0 \uc54a\uc73c\uba74\uc11c\ub3c4 \uc218\ud608 \uc804\ud30c \uac10\uc5fc\uc744 \uc608\ubc29\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

    \uae30\uc0dd\ucda9: \ub4dc\ubb3c\uc9c0\ub9cc \uce58\uba85\uc801\uc778 \uc704\ud611<\/h2>\n

    Babesia microti\ub294 \uc9c4\ub4dc\uae30\uac00 \ub9e4\uac1c\ud558\ub294 \uae30\uc0dd\ucda9\uc73c\ub85c, \ud2b9\ud788 \uba74\uc5ed \uc800\ud558\uc790\uc5d0\uac8c \uc218\ud608 \uc2dc \uc2ec\uac01\ud55c \uc704\ud5d8\uc744 \ucd08\ub798\ud569\ub2c8\ub2e4. \uc218\ud608 \uc804\ud30c \ubc14\ubca0\uc2a4\uc5f4\uc6d0\ucda9\uc99d(Transfusion-Transmitted Babesiosis, TTB)\uc758 \uc774\ud658\uc728 \ubc0f \uc0ac\ub9dd\ub960\uc740 \uc57d 19%\uc785\ub2c8\ub2e4 [17]. \ubbf8\uad6d\uc5d0\uc11c TTB \uc99d\ub840\uac00 \uc99d\uac00\ud568\uc5d0 \ub530\ub77c 10\ub144\uc774 \ub118\ub294 \uae30\uac04 \ub3d9\uc548 \ud5cc\ud608\uc790 \uac10\uc2dc, \ubd84\uc11d\ubc95 \uac1c\ubc1c, \uc5f0\uad6c\uac00 \ud65c\ubc1c\ud788 \uc9c4\ud589\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uadf8 \uacb0\uacfc \ud48d\ud1a0\ubcd1 \uc9c0\uc5ed\uc744 \ub300\uc0c1\uc73c\ub85c \ud55c \uc9c0\uc5ed\ubcc4 \ud5cc\ud608\uc790 \uc120\ubcc4 \uac80\uc0ac\uac00 \ub3c4\uc785\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc774 \uc120\ubcc4 \uac80\uc0ac\uc5d0\ub294 \ud608\uccad\ud559\uc801 \uac80\uc0ac\uc640 \ubd84\uc790 \uac80\uc0ac\uac00 \ubaa8\ub450 \uc0ac\uc6a9\ub418\uc5c8\uc2b5\ub2c8\ub2e4. 8\ub9cc 9\ucc9c \uac74\uc774 \ub118\ub294 \ud608\uc561 \uacf5\uc5ec \uac80\uccb4\ub97c \ub300\uc0c1\uc73c\ub85c \ud55c \ud55c \uc5f0\uad6c\uc5d0\uc11c\ub294 Babesia microti \uc120\ubcc4 \uac80\uc0ac \uacb0\uacfc \uc804\uccb4\uc758 0.38%\uac00 \uc591\uc131\uc73c\ub85c \ud655\uc778\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc5ec\uae30\uc5d0\ub294 \uc5f0\uc911 \uac80\ucd9c\ub41c PCR \uc591\uc131 \uc99d\ub840\ubfd0 \uc544\ub2c8\ub77c \ud56d\uccb4 \uc74c\uc131 \uc99d\ub840 13%\ub3c4 \ud3ec\ud568\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ucf54\ub124\ud2f0\ucef7\uacfc \ub9e4\uc0ac\ucd94\uc138\uce20\ucc98\ub7fc \uc120\ubcc4 \uac80\uc0ac\ub97c \uc2dc\ud589\ud55c \uc9c0\uc5ed\uc5d0\uc11c\ub294 \uc218\ud608 \uc804\ud30c \ubc14\ubca0\uc2a4\uc5f4\uc6d0\ucda9\uc99d(TTB) \uc99d\ub840\uac00 \ubcf4\uace0\ub418\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4. \ubc18\uba74, \uc120\ubcc4 \uac80\uc0ac\ub97c \ud558\uc9c0 \uc54a\uc740 \ud608\uc561\uc5d0\uc11c\ub294 18,074\uac74\uc758 \ud5cc\ud608\ub2f9 \ud55c \uac74\uaf34\ub85c TTB\uac00 \ubcf4\uace0\ub418\uc5b4 \uc704\ud5d8\uc774 \uc57d 8\ubc30 \uac10\uc18c\ud55c \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4 [18]. \uc218\ud608\uc744 \ud1b5\ud55c \ub9d0\ub77c\ub9ac\uc544 \uc804\ud30c\ub294 \ub4dc\ubb3c\uc9c0\ub9cc \uc608\ubc29\ud560 \uc218 \uc788\uc73c\uba70, \ud48d\ud1a0\ubcd1 \uc9c0\uc5ed\uc758 \ud608\uc561 \uc11c\ube44\uc2a4\uc5d0 \uc788\uc5b4 \uc810\uc810 \ub354 \uc911\uc694\ud55c \ubb38\uc81c\uac00 \ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ub9d0\ub77c\ub9ac\uc544 \uae30\uc0dd\ucda9 \uac80\ucd9c\uc5d0\ub294 \ud6c4\uce35 \ub3c4\ub9d0(thick film) \uac80\uc0ac\uac00 \ud754\ud788 \uc0ac\uc6a9\ub418\uc9c0\ub9cc, \uc2dc\uac04\uc774 \uc624\ub798 \uac78\ub9ac\uace0 \uac80\uc0ac\uc790 \uc5ed\ub7c9\uc5d0 \uc0c1\ub2f9\ud788 \uc758\uc874\ud558\uba70 \uc624\ub958 \uac00\ub2a5\uc131\uc774 \ub192\uc2b5\ub2c8\ub2e4. WHO\ub294 \ud48d\ud1a0\ubcd1 \uad6d\uac00\uc5d0\uc11c \ub9d0\ub77c\ub9ac\uc544 \ud56d\uc6d0\uc744 \uac80\ucd9c\ud558\ub294 \uace0\uac10\ub3c4 \ud6a8\uc18c \uba74\uc5ed \ubd84\uc11d(Enzyme Immunoassay, EIA)\uc758 \uc0ac\uc6a9\ub3c4 \uad8c\uace0\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4 [19]. \ud6c4\uce35 \ub3c4\ub9d0 \ud604\ubbf8\uacbd \uac80\uc0ac\uc640 EIA \ud56d\uc6d0 \uac80\uc0ac\ub294 \uc57d 100\ub9c8\ub9ac\/\u00b5L \uc815\ub3c4\uc758 \uae30\uc0dd\ucda9\ub9cc \uac80\ucd9c\ud560 \uc218 \uc788\uc73c\uba70, \uc774\ub294 \ud608\uc561 \uacf5\uc5ec 450\u00a0mL\ub2f9 \uc57d 4,500\ub9cc \ub9c8\ub9ac\uc758 \uae30\uc0dd\ucda9\uc774 \uc788\uc5b4\uc57c \uac80\ucd9c\ud560 \uc218 \uc788\ub2e4\ub294 \uc758\ubbf8\uc785\ub2c8\ub2e4 [20,21]. \uc774\ub7ec\ud55c \uac80\uc0ac\ub294 \uc800\uc218\uc900 \uae30\uc0dd\ucda9 \ud608\uc99d\uc774 \uc788\ub294 \ud608\uc561 \ub2e8\uc704\ub85c\ubd80\ud130\uc758 \uc804\ud30c\ub97c \ucc28\ub2e8\ud558\uae30 \uc704\ud55c \uac83\uc774 \uc544\ub2c8\ub77c, \uc720\uc99d\uc0c1 \uac10\uc5fc\uc744 \uc9c4\ub2e8\ud558\uae30 \uc704\ud574 \uace0\uc548\ub41c \uac80\uc0ac\uc785\ub2c8\ub2e4. \ucd5c\uadfc\uc5d0\ub294 \ud5cc\ud608\uc790 \uc120\ubcc4 \uac80\uc0ac \ud658\uacbd\uc5d0 \ub354 \uc801\ud569\ud560 \uc218 \uc788\ub294 NAT \uae30\ubc18 \ubd84\uc11d\ubc95\uc774 \ub4f1\uc7a5\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ud2b9\ud788 \ub9ac\ubcf4\uc19c RNA(rRNA) \uac80\uc0ac\uac00 \uac1c\ubc1c\ub418\uc5c8\uc73c\uba70 DNA \uae30\ubc18 \uac80\uc0ac\uc640 \ube44\uad50\ud558\uba74 \uba87 \uac00\uc9c0 \uc7a5\uc810\uc774 \uc788\uc2b5\ub2c8\ub2e4. \ub9ac\ubcf4\uc19c RNA\ub294 \uc720\uc804\uccb4 \ud575\uc0b0\ubcf4\ub2e4 \ud6e8\uc52c \ud48d\ubd80\ud558\uc5ec, P.falciparum\uc758 ring stage \uae30\uc0dd\ucda9\ub2f9 \uc57d 1 \u00d7 10^4\uac1c\uc758 rRNA \uce74\ud53c\uac00 \uc874\uc7ac\ud569\ub2c8\ub2e4 [22]. rRNA\ub97c \ud65c\uc6a9\ud558\uba74 \ub9e4\uc6b0 \uc800\uc218\uc900\uc758 \uae30\uc0dd\ucda9 \ud608\uc99d\ub3c4 \uac80\ucd9c\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. NAT \uae30\ubc18 \ubd84\uc11d\ubc95\uc740 \ub9d0\ub77c\ub9ac\uc544 \ud48d\ud1a0\ubcd1 \uc9c0\uc5ed\uacfc \ube44\ud48d\ud1a0\ubcd1 \uad6d\uac00 \ubaa8\ub450\uc5d0\uc11c \uc218\ud608 \uc804\ud30c \ub9d0\ub77c\ub9ac\uc544\ub97c \uc608\ubc29\ud558\ub294 \ub370 \uae30\uc5ec\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc778\ub3c4\ub124\uc2dc\uc544\uc758 \ud55c \uc870\uc0ac\uc5d0\uc11c\ub294 \ud5cc\ud608\uc790\uc758 4.5%\uac00 \ub9d0\ub77c\ub9ac\uc544 \ud56d\uccb4\ub97c \uac16\uace0 \uc788\uc5c8\uace0, 1.2%\ub294 PCR \uc591\uc131\uc774\uc5c8\uc2b5\ub2c8\ub2e4 [23]. 2010\ub144 \uc774\ud6c4 \ube44\ud48d\ud1a0\ubcd1 \uad6d\uac00\uc5d0\uc11c \ubcf4\uace0\ub41c 13\uac74\uc758 \uc218\ud608 \uc804\ud30c \ub9d0\ub77c\ub9ac\uc544(Transfusion-Transmitted Malaria, TTM) \uc99d\ub840\ub97c \uac80\ud1a0\ud55c \uacb0\uacfc, DNA \uae30\ubc18 PCR \uac80\uc0ac\ub85c\ub294 \uac80\uc0ac\ub41c \ud5cc\ud608\uc790 12\uba85 \uc911 10\uba85\uc5d0\uc11c \uc5f4\uc6d0\ucda9 \uac10\uc5fc\uc774 \uac80\ucd9c\ub418\uc5c8\uc73c\uba70 \uc74c\uc131\uc774\uc5c8\ub358 \ub450 \uac74\uc740 \uc5f4\ud654\ub41c \uac80\uccb4 \ubc0f \ubcf4\uad00\ub41c \uac80\uccb4\uc640 \uad00\ub828\uc774 \uc788\uc5c8\uc2b5\ub2c8\ub2e4. \ubc18\uba74, \ud56d\uccb4 EIA\ub294 \uc77c\uacf1 \uba85\uc758 \ud5cc\ud608\uc790 \uc911 \uc138 \uba85\uc5d0\uc11c\ub9cc \uc591\uc131\uc73c\ub85c \ub098\ud0c0\ub098 \uc808\ubc18\uc774 \ub118\ub294 \uc99d\ub840\ub97c \ub193\ucce4\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ubc1c\uacac\uc5d0 \ub530\ub77c, \ud2b9\ud788 \ubb34\uc99d\uc0c1 \ud5cc\ud608\uc790\uc5d0\uc11c \ud608\uccad\ud559\uc801 \ubc29\ubc95\uc758 \uc2e0\ub8b0\uc131\uc774 \uc81c\ud55c\uc801\uc774\ub77c\ub294 \uc810\uc774 \ubd80\uac01\ub418\uc5c8\uc2b5\ub2c8\ub2e4. rRNA\ub97c \uae30\ubc18\uc73c\ub85c \ud55c \ucd5c\uc2e0 \ubd84\uc790 \ubd84\uc11d\ubc95\uc740 DNA PCR\ubcf4\ub2e4 \ubbfc\uac10\ub3c4\uac00 \uc57d 1,000\ubc30 \ub354 \ub192\uc544 \uac10\uc5fc\uc744 \uc870\uae30\uc5d0 \ubc1c\uacac\ud568\uc73c\ub85c\uc368 TTM\uc744 \uc608\ubc29\ud560 \uc218 \uc788\ub294 \ub354 \ud070 \uac00\ub2a5\uc131\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4. \ub530\ub77c\uc11c \ud56d\uccb4 \uac80\uc0ac\uc758 \ud65c\uc6a9\ub3c4\uac00 \ub5a8\uc5b4\uc9c0\ub294 \ud48d\ud1a0\ubcd1 \uc9c0\uc5ed\uc5d0\uc11c\ub294 PCR\uc774 \uc120\ud638\ub418\ub294 \uac80\uc0ac\ubc95\uc784\uc744 \ub4b7\ubc1b\uce68\ud569\ub2c8\ub2e4 [24].<\/p>\n

    \uacb0\ub860<\/h2>\n

    \uc774\uac83\uc774 \ubcf4\uc5ec\uc8fc\ub294 \ubc14\ub294 \uba85\ud655\ud569\ub2c8\ub2e4. \uacfc\uac70\uc758 \uc704\ud5d8\uc5d0\ub9cc \uae30\ubc18\ud55c \uac80\uc0ac \ud328\ub110\ub85c\ub294 \ub354 \uc774\uc0c1 \ucda9\ubd84\ud558\uc9c0 \uc54a\ub2e4\ub294 \uac83\uc785\ub2c8\ub2e4. \ubaa8\ub4e0 \uc9c8\ubcd1\uc758 \ubc1c\uc0dd, \uae30\ud6c4 \ubcc0\ud654, \ub9e4\uac1c\uccb4\uc758 \uc774\ub3d9\uc740 \ubcd1\uc6d0\uccb4\uac00 \ud608\uc561 \uacf5\uae09\ub9dd\uc5d0 \uce68\ud22c\ud560 \uc218 \uc788\ub294 \uc0c8\ub85c\uc6b4 \uc7a0\uc7ac\uc801 \uc9c4\uc785\uc810\uc744 \ub9cc\ub4e4\uc5b4 \ub0c5\ub2c8\ub2e4. \ub530\ub77c\uc11c \ud5cc\ud608\uc790 \uc120\ubcc4 \uac80\uc0ac \uc804\ub7b5\uc740 \uc9c0\uc5ed\uc801 \uc0c1\ud669\uc744 \uae30\ubc18\uc73c\ub85c \ud574\uc57c \ud558\uba70, \uae30\uc874\uc758 \ub9c8\ucee4\ubfd0 \uc544\ub2c8\ub77c \ubc1c\ubcd1 \ud604\ud669\uacfc \uc9c8\ubcd1 \uc720\ubcd1\ub960\uc758 \ubcc0\ud654\ub97c \uace0\ub824\ud574\uc57c \ud569\ub2c8\ub2e4. \uc544\uc2dc\uc544 \ud0dc\ud3c9\uc591 \uc9c0\uc5ed\uc758 \ud608\uc561 \uc11c\ube44\uc2a4 \uae30\uad00\uc774 \ub098\uc544\uac00\uc57c \ud560 \ubc29\ud5a5\uc740 \uc9c0\uc5ed\ubcc4 \uc704\ud5d8 \uc694\uc778\uc758 \uc77c\uc0c1\uc801\uc778 \uac80\ud1a0, \uc9c8\ubcd1 \ubc1c\uc0dd\uc5d0 \uc2e0\uc18d\ud788 \ub300\uc751\ud558\ub294 \uc120\ubcc4 \uac80\uc0ac \ud504\ub85c\ud1a0\ucf5c, \ubcd1\uc6d0\uccb4\uc5d0 \uc801\ud569\ud55c \uac80\uc0ac\ubc95(\ud608\uccad \uac80\uc0ac\ub098 NAT \ub4f1)\uc744 \uc801\uc6a9\ud558\ub294 \uac83\uc785\ub2c8\ub2e4. \uc774\ucc98\ub7fc \uadfc\uac70 \uae30\ubc18\uc758 \uc720\uc5f0\ud55c \uc804\ub7b5\uc744 \ub3c4\uc785\ud558\ub294 \uac83\uc774 \ub2e4\uc591\ud55c \uc5ed\ud559\uc801 \ud658\uacbd\uc5d0\uc11c \ud608\uc561 \uc548\uc804\uc131\uc744 \uac15\ud654\ud558\ub294 \ud575\uc2ec\uc774 \ub420 \uac83\uc785\ub2c8\ub2e4.<\/p>\n

    \n

    \ucc38\uace0 \ubb38\ud5cc<\/em><\/p>\n

    [1]<\/a> World Health Organization. 2009. “Screening Donated Blood for Transfusion-Transmissible Infections: Recommendations.” <\/span>Screening for transfusion-transmissible infections<\/span><\/i> (WHO Press). <\/span>https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK142989\/<\/span>.\u00a0<\/span><\/p>\n

    [2] Asia Pacific Blood Network. 2019. “Dengue and the Blood Supply.” White Paper, 12.<\/span><\/p>\n

    [3]<\/a> Viet, Le, Nguyen Thi Ngoc Lan, Phung Xuan Ty, Bj\u00f6rn Bj\u00f6rkvoll, Hedda Hoel, Tore Gutteberg, Anne Husebekk, Stig Larsen, Eystein Skjerve, and Hans Husum. 2012. “Prevalence of hepatitis B & hepatitis C virus infections in potential blood donors in rural Vietnam.” <\/span>The Indian Journal of Medical Research<\/span><\/i> (Indian Council of Medical Research New Delhi) 136 (1): 74-81. <\/span>https:\/\/www.researchgate.net\/publication\/230656382_Prevalence_of_hepatitis_B_hepatitis_C_virus_infections_in_potential_blood_donors_in_rural_Vietnam<\/span>.\u00a0<\/span><\/p>\n

    [4]<\/a> World Health Organization. 2012. <\/span>Blood Donor Selection: Guidelines on Assessing Donor Suitability for Blood Donation.<\/span><\/i> Geneva: World Health Organization. <\/span>https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK138218\/<\/span>.\u00a0<\/span><\/p>\n

    [5]<\/a> Peeling, Rosanna W., David Mabey, Mary L.Kamb, Xiang-Sheng Chen, Justin D.Radolf, and Adele S.Benzaken. \u201cSyphilis.\u201d Nature Reviews Disease Primers 3, no. 1 (2017\ub144 10\uc6d4 12\uc77c). <\/span>https:\/\/doi.org\/10.1038\/nrdp.2017.73<\/span>.\u00a0<\/span><\/p>\n

    [6]<\/a> Rattanatham, Rujikorn, Wanida Mala, Kwuntida Uthaisar Kotepui, Frederick Ramirez Masangkay, Chutima Rattanawan, Supakanya Lasom, Kinley Wangdi, and Manas Kotepui. \u201cA Systematic Review and Meta-Analysis of the Prevalence and Risk of Syphilis among Blood Donors in Thailand.\u201d <\/span>Scientific Reports<\/span><\/i> 15, no. 1 (2025\ub144 3\uc6d4 18\uc77c). <\/span>https:\/\/doi.org\/10.1038\/s41598-025-94332-3<\/span><\/a>.<\/span><\/p>\n

    [7]<\/a> Moreira-Soto, Andres, Ignacio Postigo-Hidalgo, Ximena Tabares, Yannik Roell, Carlo Fischer, Eduardo Gotuzzo, Thomas Jaenisch, Jos\u00e9 Eduardo Levi, Yaniv Lustig, and Jan Felix Drexler. \u201cTransfusion-Transmitted Infections: Risks and Mitigation Strategies for Oropouche Virus and Other Emerging Arboviruses in Latin America and the Caribbean.\u201d <\/span>The Lancet Regional Health – Americas<\/span><\/i> 46 (2025\ub144 6\uc6d4): 101089. <\/span>https:\/\/doi.org\/10.1016\/j.lana.2025.101089<\/span>.\u00a0<\/span><\/p>\n

    [8]<\/a> Bangalee, Avania, Sachin Bhoora, and Rivak Punchoo. \u201cEvaluation of Serological Assays for the Diagnosis of HIV Infection in Adults.\u201d <\/span>South African Family Practice<\/span><\/i> 63, no. 1 (2021\ub144 10\uc6d4 25\uc77c). <\/span>https:\/\/doi.org\/10.4102\/safp.v63i1.5316<\/span>.\u00a0<\/span><\/p>\n

    [9]<\/a> Huynh, Katie. \u201cHIV Testing.\u201d StatPearls [\uc778\ud130\ub137]., 2023\ub144 4\uc6d4 17\uc77c. <\/span>https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK482145\/<\/span>.\u00a0\u00a0<\/span><\/p>\n

    [10]<\/a> \u201cClinical Screening and Diagnosis for Hepatitis C.\u201d Centers for Disease Control and Prevention, 2025\ub144 1\uc6d4 31\uc77c. <\/span>https:\/\/www.cdc.gov\/hepatitis-c\/hcp\/diagnosis-testing\/index.html<\/span>.\u00a0\u00a0<\/span><\/p>\n

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    [16] Centers for Disease Control and Prevention (CDC). \u201cUpdate: West Nile Virus Screening of Blood Donations and Transfusion-Associated Transmission\u2014United States, 2003.\u201d <\/span>MMWR Morb Mortal Wkly Rep <\/span><\/i>53, no. 13 (2004\ub144 4\uc6d4 12\uc77c): 2184.\u00a0<\/span><\/p>\n

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    [24]<\/a> Galel, Susan A.\u201cLaboratory Detection of Donors Implicated in Transfusion\u2010transmitted Malaria.\u201d <\/span>Transfusion<\/span><\/i> 64, no. 12 (2024\ub144 11\uc6d4 6\uc77c): 2325\u201331. <\/span>https:\/\/doi.org\/10.1111\/trf.18061<\/span>.\u00a0 <\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

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