{"id":146525,"date":"2023-12-04T06:30:13","date_gmt":"2023-12-04T06:30:13","guid":{"rendered":"https:\/\/labinsights.com\/acf_article\/%ec%8b%ac%ec%9e%a5-%eb%b6%80%ec%a0%84%ec%9d%98-%ec%9d%91%ea%b3%a0-%ec%9e%a5%ec%95%a0-%eb%b3%91%ed%83%9c%ec%83%9d%eb%a6%ac%ed%95%99-%eb%b0%8f-%ec%9e%84%ec%83%81-%ea%b4%80%eb%a6%ac\/"},"modified":"2026-02-25T09:29:56","modified_gmt":"2026-02-25T09:29:56","slug":"coagulation-disorders-in-heart-failure-pathophysiology-and-clinical-management","status":"publish","type":"acf_article","link":"https:\/\/labinsights.com\/ko\/disease-area\/cardiology\/coagulation-disorders-in-heart-failure-pathophysiology-and-clinical-management\/","title":{"rendered":"\uc2ec\uc7a5 \ubd80\uc804\uc758 \uc751\uace0 \uc7a5\uc560: \ubcd1\ud0dc\uc0dd\ub9ac\ud559 \ubc0f \uc784\uc0c1 \uad00\ub9ac"},"content":{"rendered":"

\uc2ec\uc7a5 \ubd80\uc804\uc758 \ud608\uc561 \uc751\uace0 \uc7a5\uc560<\/h2>\n

\uc2ec\uc7a5 \ubd80\uc804(HF)\uc740 \uc2ec\uc7a5\uc758 \uad6c\uc870\uc801 \ub610\ub294 \uae30\ub2a5\uc801 \uc7a5\uc560\ub85c \uc778\ud574 \ubc1c\uc0dd\ud558\ub294 \uc784\uc0c1 \uc99d\ud6c4\uad70\uc73c\ub85c, \uc6b4\ub3d9 \ub610\ub294 \ud734\uc2dd \uc2dc \uc2ec\ub0b4\uc555 \uc0c1\uc2b9 \ubc0f\/\ub610\ub294 \ubd80\uc801\uc808\ud55c \uc2ec\ubc15\ucd9c\ub7c9\uc744 \ucd08\ub798\ud569\ub2c8\ub2e4. \uc774 \uc0c1\ud0dc\ub294 \ub3d9\ub9e5 \ubc0f \uc815\ub9e5 \ud608\uc804\uc99d \uc0ac\uac74\uc758 \uc704\ud5d8 \uc99d\uac00\uc640 \uad00\ub828\uc774 \uc788\uc2b5\ub2c8\ub2e4. \uc784\uc0c1\uc758\ub4e4 \uc0ac\uc774\uc5d0 \uc774 \ubb38\uc81c\uc5d0 \ub300\ud55c \uc778\uc2dd\uc774 \ub192\uc544\uc9c0\uace0, \uc774\ub97c \uad00\ub9ac\ud558\uae30 \uc704\ud55c \ub354 \ub9ce\uc740 \uc5f0\uad6c\uc640 \ub354 \uba85\ud655\ud55c \uac00\uc774\ub4dc\ub77c\uc778\uc774 \uc2ec\uc7a5 \ubd80\uc804 \ud658\uc790\ub4e4 \uc0ac\uc774\uc5d0\uc11c \uc751\uace0 \uc7a5\uc560\uc758 \ub354 \ub098\uc740 \uc9c4\ub2e8 \ubc0f \uce58\ub8cc\ub97c \ub4b7\ubc1b\uce68\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc2ec\uc7a5 \ubd80\uc804 \uc751\uace0 \uc7a5\uc560\uc758 \ubcd1\ud0dc\uc0dd\ub9ac\ud559<\/h2>\n

HF\ub294 \uc88c\uc2ec\uc2e4 \ubc15\ucd9c\ub960(LVEF)\uc744 \uae30\uc900\uc73c\ub85c, \ubc15\ucd9c\ub960\uc774 \uac10\uc18c\ub41c HF(HFrEF), \ubc15\ucd9c\ub960\uc774 \uc57d\uac04 \uac10\uc18c\ub41c HF(HFmrEF), \ubc15\ucd9c\ub960\uc774 \ubcf4\uc874\ub41c HF(HFpEF)\uc758 3\uac00\uc9c0 \uc544\ud615\uc73c\ub85c \ub098\ub269\ub2c8\ub2e4. \ubaa8\ub4e0 \uc544\ud615\uc5d0\ub294 \ub2e4\uc591\ud55c \ud608\uc804\uc0c9\uc804 \ud569\ubcd1\uc99d \uc704\ud5d8\uc744 \ud3ec\ud568\ud558\uc5ec \ud2b9\uc815\ud55c \uc784\uc0c1\uc801 \ud2b9\uc131\uacfc \ud754\ud55c \ub3d9\ubc18 \uc9c8\ud658\uc774 \uc788\uc2b5\ub2c8\ub2e4[2].<\/p>\n

\"coagulation_disorders_in_heart_failure<\/p>\n

HF\uc640 \ud608\uc804\uc99d\uc740 \uc885\uc885 \uba87 \uac00\uc9c0 \uc774\uc720\ub85c \uc5f0\uad00\ub429\ub2c8\ub2e4. \uc6b0\uc120, \uc2ec\uc7a5 \ubd80\uc804\uc758 \uc8fc\uc694 \uc6d0\uc778\uc778 \ud5c8\ud608\uc131 \uc2ec\uc7a5\ubcd1\uc740 \ud608\uc18c\ud310 \ud65c\uc131\ud654 \ubc0f \uc751\uc9d1\uc744 \ud1b5\ud574 \ub3d9\ub9e5 \ud608\uc804\uc744 \ud615\uc131\ud558\uae30 \uc27d\uc2b5\ub2c8\ub2e4. \uc815\ub9e5 \ud608\uc804 \uc0c9\uc804\uc99d(VTE) \ub610\ud55c \uc2ec\uc7a5 \ubd80\uc804\uc5d0\uc11c \ud754\ud558\uac8c \ubc1c\uc0dd\ud558\uba70, \uc2ec\ud608\uad00 \uc0c9\uc804\uc131 \ub1cc\uc878\uc911 \ubc0f \uae09\uc0ac\uc758 \uc704\ud5d8 \uc99d\uac00\uc5d0 \uae30\uc5ec\ud569\ub2c8\ub2e4. \ud608\uc804 \uc0c9\uc804\uc99d \ubc0f \ub1cc\uc878\uc911\uc758 \uc704\ud5d8\uc740 \uc2ec\uc7a5 \ubd80\uc804 \ud658\uc790\uac00 \uc2ec\ubc29\uc138\ub3d9(AF)\uacfc \uac19\uc740 \ub2e4\ub978 \ub3d9\ubc18 \uc9c8\ud658\uc774 \uc788\ub294 \uacbd\uc6b0 \ud2b9\ud788 \ub192\uc2b5\ub2c8\ub2e4. \uc2ec\uc7a5 \ubd80\uc804\uc73c\ub85c \uc0c8\ub85c \uc9c4\ub2e8\ub41c \ud658\uc790\uc758 \uc808\ubc18 \uc774\uc0c1\uc774 \uc2ec\ubc29\uc138\ub3d9(AF)\uc744 \uc553\uace0 \uc788\ub294 \uac83\uc73c\ub85c \ubc1d\ud600\uc84c\uc73c\uba70 \uc2ec\ubc29\uc138\ub3d9\uacfc \uc2ec\uc7a5 \ubd80\uc804 \ubaa8\ub450 \uc874\uc7ac\ud560 \uacbd\uc6b0 \uc0ac\ub9dd \uc704\ud5d8\uc774 \ub354 \ud070 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4.<\/p>\n

\"coagulation_disorders_in_heart_failure<\/p>\n

\ube44\ub974\ucf54 \uc0bc\uac01 \uc9c8\ud658\uc758 \uc138 \uac00\uc9c0 \uad6c\uc131 \uc694\uc18c\uc778 \ub0b4\ud53c \uae30\ub2a5 \uc774\uc0c1, \ud608\ub958 \uc815\uccb4, \uacfc\uc751\uace0\uc131 \ubaa8\ub450\uc758 \uc774\uc0c1\uc740 \uc2ec\uc7a5 \ubd80\uc804\uc5d0\uc11c \ud608\uc804\uc99d\uc5d0 \ub300\ud55c \ucde8\uc57d\uc131\uc744 \uc99d\uac00\uc2dc\ud0b5\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \ub3d9\ub9e5 \ubc0f \uc815\ub9e5 \ud608\uc804\uc99d\uc758 \ubcd1\uc778\uc740 \ub2e4\ub985\ub2c8\ub2e4. \ub3d9\ub9e5 \ud608\uc804\uc740 \ud608\uc18c\ud310\uc774 \ud48d\ubd80\ud558\uace0 \ub192\uc740 \uc804\ub2e8 \uc2a4\ud2b8\ub808\uc2a4 \ud558\uc5d0\uc11c \ud615\uc131\ub418\ub294 \ubc18\uba74, \uc815\ub9e5 \ud608\uc804\uc740 \ud53c\ube0c\ub9b0\uc774 \ud48d\ubd80\ud558\uace0 \ub0ae\uc740 \uc804\ub2e8 \uc2a4\ud2b8\ub808\uc2a4 \ud658\uacbd\uc5d0\uc11c \ud615\uc131\ub429\ub2c8\ub2e4. HF\uc758 \ubcd1\uc778 \ub610\ub294 \uadf8 \ub3d9\ubc18\uc9c8\ud658\uacfc \uad00\uacc4\uc5c6\uc774, \ud608\uc18c\ud310 \uae30\ub2a5\uc758 \ucc28\uc9c8\uacfc HF\uc5d0\uc11c \ubcf4\uc774\ub294 \uc751\uace0 \uce90\uc2a4\ucf00\uc774\ub4dc\uc640\uc758 \uc0c1\ud638 \uc791\uc6a9\uc740 \ud608\uc804\uc0dd\uc131\uc744 \ucd09\uc9c4\ud569\ub2c8\ub2e4[2].<\/p>\n

\ud608\uc804\uc0c9\uc804 \ud569\ubcd1\uc99d\uc740 \uc77c\ubc18\uc801\uc73c\ub85c \uc2ec\uc7a5 \ubd80\uc804 \ud658\uc790\uc758 \uc8fc\uc694 \ubb38\uc81c\ub85c \uc778\uc2dd\ub418\uc9c0\ub294 \uc54a\uc9c0\ub9cc, \uc774 \uc0c1\ud0dc\ub294 \uc2e4\uc9c8\uc801\uc778 \uc751\uace0 \uc7a5\uc560\uc640 \uad00\ub828\uc774 \uc788\uc2b5\ub2c8\ub2e4[3]. \uc608\ub97c \ub4e4\uc5b4, \ub1cc\uc878\uc911 \ubc1c\uc0dd\ub960\uc740 \uc2ec\uc7a5 \ubd80\uc804 \uc9c4\ub2e8 \ub610\ub294 \ub300\uc0c1\ubd80\uc804 \ud6c4 \uccab \ub2ec\uc5d0 \ub354 \ub192\uc73c\uba70 \uae09\uc131 \uc0ac\ub840 \ud6c4 6\uac1c\uc6d4 \uc774\ub0b4\uc5d0 \uac10\uc18c\ud569\ub2c8\ub2e4[4]. HF \ud658\uc790\ub4e4\uc5d0\uc11c \uc804\ud608\uc804\uc131 \ud45c\ud604\ud615\uc740 (1) \ub9cc\uc131 \uc800\uc0b0\uc18c\uc99d\uc5d0 \uc758\ud574 \uc720\ub3c4\ub41c \uc804\uc2e0 \uc5fc\uc99d \ubc18\uc751, (2) \uc804\ud608\uc804 \ubd84\uc790\uc758 \ub18d\ub3c4 \uc99d\uac00, \ub610\ub294 (3) \ub3d9\ub9e5 \ubc0f \uc815\ub9e5 \ub0b4\ud53c \uae30\ub2a5\uc7a5\uc560 \ub54c\ubb38\uc77c \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\"coagulation_disorders_in_heart_failure<\/p>\n

\uc2ec\uc7a5 \ubd80\uc804\uc740 \ub610\ud55c \uc545\ud654\ub41c \uc7a5\uc560, \ubcd1\uc6d0 \uc7ac\uc785\uc6d0 \uc99d\uac00, \ub1cc\uc878\uc911 \ud6c4 \uc0ac\ub9dd\ub960 \uc99d\uac00\uc758 \ub3c5\ub9bd\uc801\uc778 \uc704\ud5d8 \uc778\uc790\uc778 \uac83\uc73c\ub85c \ubc1d\ud600\uc84c\uc2b5\ub2c8\ub2e4. \uadf8\ub7fc\uc5d0\ub3c4 \ubd88\uad6c\ud558\uace0, HF\uc5d0\uc11c \uc751\uace0 \uc774\uc0c1\uacfc \uad00\ub828\ub41c \uc774\ud658\uc728 \ubc0f \uc0ac\ub9dd\ub960\uc744 \uac10\uc18c\uc2dc\ud0a4\ub294 \ub370 \uc788\uc5b4 \ud56d\uc751\uace0 \ubc0f \ud56d\ud608\uc18c\ud310 \uc694\ubc95\uc758 \uc5ed\ud560\uc744 \ub2e4\ub8e8\ub294 \uba85\ud655\ud55c \uc9c0\uce68\uc740 \uc5c6\uc2b5\ub2c8\ub2e4[1]. \ub530\ub77c\uc11c HF\uc5d0\uc11c \ud608\uc804\uc0c9\uc804 \ud569\ubcd1\uc99d\uc758 \uc704\ud5d8 \uc99d\uac00\ub294 \uacfc\uc18c \ud3c9\uac00\ub41c \uc784\uc0c1\uc801 \uacfc\uc81c\ub97c \ub098\ud0c0\ub0b4\ub294\ub370, HF\ub294 \uc774\ud658\uc728\uacfc \uc0ac\ub9dd\ub960\uc744 \uc545\ud654\uc2dc\ud0ac \uc218 \uc788\ub294 \uc804\ud608\uc804 \uc0c1\ud0dc\ub97c \ud2b9\uc9d5\uc73c\ub85c \ud558\uae30 \ub54c\ubb38\uc785\ub2c8\ub2e4.<\/p>\n

HF\uc5d0\uc11c \uc751\uace0 \uc7a5\uc560\uc758 \uc784\uc0c1 \uad00\ub9ac<\/h2>\n

\uc2ec\uc7a5 \ubd80\uc804 \ud658\uc790\ub4e4\uc5d0\uc11c, \ub0b4\ud53c \uae30\ub2a5 \uc774\uc0c1 \ubc0f \ub0ae\uc740 \uc2ec\ubc15\ucd9c\ub7c9, \ube44\uc815\uc0c1 \ud608\ub958 \ubc0f \uc815\uccb4\uc640 \uad00\ub828\ub41c \uc0c1\ud0dc\uc640 \ud568\uaed8 \ud65c\uc131\ud654\ub41c \uc751\uace0 \ubc0f\/\ub610\ub294 \ud608\uc18c\ud310 \ud65c\uc131\ud654\uc758 \ud45c\uc9c0\uc790\uac00 \uad00\ucc30\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ub610\ud55c, \uba87 \uac00\uc9c0 \ud754\ud788 \uad00\ucc30\ub418\ub294 \ub3d9\ubc18\uc9c8\ud658\uc774 \uc885\uc885 HF\ub97c \ubcf5\uc7a1\ud558\uac8c \ub9cc\ub4e4\uc5b4 \ud608\uc804\uc0c9\uc804 \uc704\ud5d8\uc744 \ub354\uc6b1 \uc99d\uac00\uc2dc\ud0b5\ub2c8\ub2e4.<\/p>\n

\uc800\ubd84\uc790\ub7c9 \ud5e4\ud30c\ub9b0\uc5d0 \uc758\ud55c \ud608\uc804 \uc0c9\uc804\uc99d \uc608\ubc29\uc740 \uae08\uae30 \uc0ac\ud56d\uc774 \uc5c6\ub294 \uae09\uc131 HF\ub85c \uc785\uc6d0\ud55c \ud658\uc790\uc640 \uc7a5\uae30\uac04 \uae30\uacc4\uc801 \uc21c\ud658 \uc9c0\uc9c0\ub85c \uce58\ub8cc\ubc1b\uc740 \ud658\uc790\uc5d0\uac8c \uad8c\uc7a5\ub429\ub2c8\ub2e4[1]. \uc9c0\ub09c 10\ub144 \ub3d9\uc548, \uc9c1\uc811 \uacbd\uad6c \ud56d\uc751\uace0\uc81c(DOAC)\uac00 \ub610\ud55c \ube44\ud310\ub9c9 AF\uc5d0\uc11c \ub1cc\uc878\uc911 \ubc0f \uc804\uc2e0 \uc0c9\uc804\uc99d(SSE)\uc758 \uce58\ub8cc \ubc0f \uc608\ubc29\uc744 \uc704\ud574 \uc2b9\uc778\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc774 \uc57d\ubb3c\ub4e4\uc740 \ucd9c\ud608 \uc704\ud5d8\uc774 \ub0ae\uc740 \uc640\ud30c\ub9b0\uc758 \ub300\uc548\uc785\ub2c8\ub2e4[3].<\/p>\n

AF \ubc0f HF \ud658\uc790\ub4e4\uc5d0\uc11c \ud56d\uc751\uace0 \uc694\ubc95\uc740 \uc774\ub7ec\ud55c \ud658\uc790\ub4e4\uc5d0\uc11c \ub192\uc740 \ud608\uc804\uc0c9\uc804 \uc704\ud5d8\uc744 \uac10\uc18c\uc2dc\ud0a4\ub294 \ub370 \ud544\uc218\uc801\uc778 \uac83\uc73c\ub85c \ub110\ub9ac \uac04\uc8fc\ub429\ub2c8\ub2e4. ESC \uc9c0\uce68\uc740 AF\uc5d0\uc11c \ub1cc\uc878\uc911\uc744 \uc608\ubc29\ud558\uae30 \uc704\ud574 \uc640\ud30c\ub9b0\ubcf4\ub2e4 DOAC\uc758 \uc0ac\uc6a9\uc744 \uad8c\uc7a5\ud558\ub294\ub370, \uc774\ub294 \uc774\ub7ec\ud55c \uc57d\ubb3c\uc774 \ubcf4\ub2e4 \uc548\uc804\ud55c \uc784\uc0c1 \ud504\ub85c\ud30c\uc77c\ub85c \uc720\uc0ac\ud558\uac8c \ud6a8\uacfc\uc801\uc774\uae30 \ub54c\ubb38\uc785\ub2c8\ub2e4. \uadf8\ub7ec\ub098 HF \ud658\uc790\ub294 \ubb34\uc791\uc704 \ub300\uc870 \uc2dc\ud5d8\uc5d0\uc11c \uacfc\uc18c \ub300\ud45c\ub429\ub2c8\ub2e4[3].<\/p>\n

AF\uac00 \uc788\ub294 \uc2ec\uc7a5 \ubd80\uc804 \ud658\uc790\uc5d0\uc11c \uc544\ud53d\uc0ac\ubc18 \ubc0f \ub2e4\ube44\uac00\ud2b8\ub780\uacfc \uac19\uc740 DOAC(\ub9ac\ubc14\ub85d\uc0ac\ubc18 \uc81c\uc678)\ub294 \ubaa8\ub4e0 \uc2e0\uae30\ub2a5 \uc218\uc900\uc5d0\uc11c \uc640\ud30c\ub9b0\ubcf4\ub2e4 \ucd1d \ucd9c\ud608 \ubc0f \uc0ac\ub9dd \uc704\ud5d8\uc774 \ub354 \ub0ae\uc558\uc2b5\ub2c8\ub2e4. DOAC \uce58\ub8cc\ub294 \uc640\ud30c\ub9b0\ubcf4\ub2e4 \uc0c1\ub2f9\ud788 \ub35c \ubcf5\uc7a1\ud558\uc9c0\ub9cc, \uc2ec\uc7a5 \ubd80\uc804 \ud658\uc790\uc5d0\uc11c\uc758 \uc0ac\uc6a9\uc740 \ud655\uc2e4\ud55c \ubb38\uc81c\uac00 \uc544\ub2d9\ub2c8\ub2e4. \uc2e0\uc7a5 \uae30\ub2a5\uc740 HF \ud658\uc790\ub4e4\uc5d0\uc11c \uc77c\ubc18\uc801\uc73c\ub85c \ubcc0\ub3d9\ud588\uc73c\uba70, \ub54c\ub54c\ub85c DOAC \uc6a9\ub7c9 \uc870\uc808\uc774 \ud544\uc694\ud588\uc9c0\ub9cc, \uc2e4\uc81c\ub85c\ub294 \uc774\ub7ec\ud55c \uc870\uc808\uc774 \ub4dc\ubb3c\uc5c8\uc2b5\ub2c8\ub2e4. \uc2e0\uc7a5 \uae30\ub2a5\uc758 \uc57d\uac04\uc758 \uac10\uc18c\uc870\ucc28\ub3c4 DOAC \uce58\ub8cc \ud658\uc790\uc758 \ucd9c\ud608 \uc704\ud5d8 \uc99d\uac00\uc640 \uad00\ub828\uc774 \uc788\uc5c8\uc73c\uba70, \uc2e0\uc911\ud55c \ubaa8\ub2c8\ud130\ub9c1\uacfc \uc801\uc808\ud55c \uc6a9\ub7c9 \uc870\uc815\uc758 \ud544\uc694\uc131\uc744 \uac15\uc870\ud574 \uc8fc\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n

\"coagulation_disorders_in_heart_failure<\/p>\n

\ud56d\uc751\uace0 \ud074\ub9ac\ub2c9 \ub610\ub294 \uc784\uc0c1 \uc57d\uc0ac\uc758 \uc804\ubb38 \uc9c4\ub8cc\ub294 \uac1c\uc120\ub41c DOAC \uc6a9\ub7c9 \uc870\uc815 \ubc0f \uacb0\uacfc\uc640 \uad00\ub828\uc774 \uc788\uc2b5\ub2c8\ub2e4. \uc2dc\ud5d8\uae30\uad00 \uac04 \uad00\ucc30\ub41c \uc131\uacfc \ubcc0\ud654\uc5d0 \ub300\ud55c \ucd94\uac00 \uc5f0\uad6c\ub294 DOAC \uce58\ub8cc \uc2dc\ud5d8\ub300\uc0c1\uc790\uc5d0 \ub300\ud55c \uce58\ub8cc\uc758 \uc9c8\uc744 \ub354\uc6b1 \uac1c\uc120\ud560 \uc218 \uc788\ub294 \uae30\ud68c\ub97c \uc81c\uacf5\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4[4].<\/p>\n

\ucd94\uac00 \uc5f0\uad6c\uc758 \ud544\uc694\uc131<\/h2>\n

\uc804 \uc138\uacc4\uc801\uc73c\ub85c 1%~2%\uc758 \uc720\ubcd1\ub960\uc744 \ubcf4\uc774\ub294 \uc2ec\uc7a5 \ubd80\uc804\uc740 800\ub9cc \uba85 \uc774\uc0c1\uc758 \uc131\uc778\uc5d0\uac8c \uc601\ud5a5\uc744 \ubbf8\uce60 \uac83\uc73c\ub85c \uc608\uc0c1\ub418\ub294 \uc8fc\uc694 \uae00\ub85c\ubc8c \uc9c8\ubcd1\uc774\uba70, 2030\ub144\uae4c\uc9c0 \ucd1d \uc2ec\uc7a5 \ubd80\uc804 \uad00\ub828 \ube44\uc6a9\uc740 700\uc5b5 \ub2ec\ub7ec\ub85c \uc99d\uac00\ud560 \uac83\uc73c\ub85c \ucd94\uc815\ub429\ub2c8\ub2e4. \uc774\uc2dd\ud615 \uc2ec\uc7a5 \uc81c\uc138\ub3d9\uae30 \ubc0f \uc2ec\uc7a5 \uc7ac\ub3d9\uae30\ud654 \uc694\ubc95\uc758 \ud1b5\ud569\uacfc \uac19\uc740 \ucd5c\uadfc\uc758 \uc99d\uac70 \uae30\ubc18 \uc2ec\uc7a5 \ubd80\uc804 \uc758\ub8cc \uad00\ub9ac \ubc1c\uc804\uc5d0\ub3c4 \ubd88\uad6c\ud558\uace0, \uc2ec\uc7a5 \ubd80\uc804\uacfc \uad00\ub828\ub41c \uc0ac\ub9dd\ub960\uc740 5\ub144 \uc2dc\uc810\uc5d0 \uc57d 50%\ub85c \uc5ec\uc804\ud788 \ub192\uc2b5\ub2c8\ub2e4.<\/p>\n

HF \ud658\uc790\uac00 \ud2b9\ud788 AF\uac00 \uc788\uc744 \ub54c \ub192\uc740 \ud608\uc804 \uc0c9\uc804\uc99d \uc704\ud5d8\uc5d0 \ub178\ucd9c\ub41c\ub2e4\ub294 \uc810\uc744 \uac10\uc548\ud560 \ub54c, DOAC \uce58\ub8cc\ub294 \uc88b\uc740 \uc548\uc804\uc131 \ud504\ub85c\ud30c\uc77c\ub85c \ud608\uc804 \uc0c9\uc804\uc99d \uc0ac\uac74\uc758 \uc704\ud5d8\uc744 \uc904\uc774\uae30 \uc704\ud55c \ud569\ub9ac\uc801\uc778 \uc811\uadfc\ubc95\uc73c\ub85c \ubcf4\uc785\ub2c8\ub2e4. \ud558\uc9c0\ub9cc, \ud2b9\uc815\ud55c \ub370\uc774\ud130\uc758 \uacb0\uc5ec\ub85c \uc778\ud574, \uc784\uc0c1 \uacb0\uc815\uc740 \ud604\uc7ac, \uc77c\ubc18 AF \uac1c\uccb4\uad70\uc5d0\uc11c \ud070 RCT\uc758 \uc99d\uac70\ub85c\ubd80\ud130 \uc870\uc815\ub429\ub2c8\ub2e4.<\/p>\n

HF\uc5d0\uc11c DOAC\ub97c \uc0ac\uc6a9\ud560 \ub54c \uba87 \uac00\uc9c0 \uc911\uc694\ud55c \uc9c8\ubb38\uc774 \uc544\uc9c1 \ud574\uacb0\ub418\uc9c0 \uc54a\uc558\uc73c\uba70, \ubcf4\ub2e4 \uc2ec\uce35\uc801\uc778 \ubd84\uc11d\uc774 \ud544\uc694\ud569\ub2c8\ub2e4. DOAC\uac00 HF \uc545\ud654 \ub610\ub294 \uc785\uc6d0\uacfc \uac19\uc740 \ud2b9\uc815 HF \ud3c9\uac00\ubcc0\uc218\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce69\ub2c8\uae4c? \ub3d9\ubc18\uc9c8\ud658\uc774 \uc788\ub294 HF-AF \ud658\uc790\uc5d0\uc11c \ud56d\uc751\uace0\uc81c\ub294 \uc5b4\ub5bb\uac8c \uad00\ub9ac\ud574\uc57c \ud569\ub2c8\uae4c? HF-AF-CAD \ud658\uc790\ub4e4\uc5d0\uc11c \ud56d\ud608\uc18c\ud310\uacfc \ud56d\uc751\uace0\uc81c\ub97c \uc5b4\ub5bb\uac8c \uacb0\ud569\ud574\uc57c \ud569\ub2c8\uae4c? LV \ud608\uc804\uc774 \uc788\ub294 HFAF \ud658\uc790\uc5d0\uc11c \uc548\uc804\ud558\uace0 \ud6a8\uacfc\uc801\uc73c\ub85c DOAC\ub97c \uc0ac\uc6a9\ud560 \uc218 \uc788\uc2b5\ub2c8\uae4c? LV \ud608\uc804\uacfc AF \uc704\ud5d8\uc774 \ubaa8\ub450 \uc99d\uac00\ub41c \uc2ec\uc7a5 \ubd80\uc804 \ud658\uc790\ub4e4\uc5d0\uc11c DOAC \uc694\ubc95\uc740 \uc5b8\uc81c \uc2dc\uc791\ud574\uc57c \ud569\ub2c8\uae4c?<\/p>\n

HF\ub294 \ud45c\uc801 \uc784\uc0c1\uc2dc\ud5d8\uacfc \uc774\uc0c1\uc0ac\ub840 \uc81c\ud55c\uc5d0 \ub9de\ucd98 \uce58\ub8cc\uac00 \ud544\uc694\ud55c \uace0\uc720\ud55c \uc784\uc0c1 \ud658\uacbd\uc744 \ub098\ud0c0\ub0c5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc5f0\uad6c\ub294 \ubc29\ub300\ud55c \uc2ec\uc7a5 \ubd80\uc804 \ud658\uc790\uad70\uacfc \ub2e8\uc77c\ud55c \ub2e4\uc591\ud55c \uc784\uc0c1 \uc2dc\ub098\ub9ac\uc624\uc5d0\uc11c DOAC \uc120\ud0dd\uc758 \uc784\uc0c1\uc801 \uacb0\uc815\uc744 \uc815\uc758\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub420 \uac83\uc785\ub2c8\ub2e4. [3]<\/p>\n

*DOAC: 2023 ISTH SSC\ub294 \ud22c\uc5ec \ubc29\uc2dd \ubc0f \ud2b9\uc815 \ud45c\uc801(\uc608: \uacbd\uad6c \uc778\uc790 Xia \uc5b5\uc81c\uc81c, \ube44\uacbd\uad6c \uc778\uc790 XIIa \uc5b5\uc81c\uc81c)\uc5d0 \ub530\ub77c \ud56d\uc751\uace0\uc81c\ub97c \uc124\uba85\ud560 \uac83\uc744 \uad8c\uc7a5\ud569\ub2c8\ub2e4. (5)<\/em><\/p>\n

\ucc38\uace0 \ubb38\ud5cc<\/em>:<\/p>\n

\n

 <\/p>\n

[1]<\/a>\u00a0SINIARSKI, A.et al. (2023) \u2018Blood coagulation disorders in heart failure: From basic science to clinical perspectives\u2019, Journal of Cardiac Failure, 29(4), pp. 517\u2013526. doi:10.1016\/j.cardfail.2022.12.012.<\/p>\n

[2]<\/a>\u00a0Kim, J.H. et al. (2016) \u2018Coagulation abnormalities in heart failure: Pathophysiology and therapeutic implications\u2019, Current Heart Failure Reports, 13(6), pp. 319\u2013328. doi:10.1007\/s11897-016-0308-6.<\/p>\n

[3]<\/a>\u00a0Paolillo, S.et al. (2020) \u2018Direct oral anticoagulants across the heart failure spectrum: The Precision Medicine Era\u2019, Heart Failure Reviews, 27(1), pp. 135\u2013145. doi:10.1007\/s10741-020-09994-0.<\/p>\n

[4]<\/a>\u00a0Jackevicius, C.A. et al. (2021) \u2018Bleeding risk of direct oral anticoagulants in patients with heart failure and atrial fibrillation\u2019, Circulation: Cardiovascular Quality and Outcomes, 14(2). doi:10.1161\/circoutcomes.120.007230.<\/p>\n

[5]\u00a0<\/a>Barnes, G.D. et al. (2023) \u2018Recommendation on the nomenclature for anticoagulants: Updated communication from the International Society on Thrombosis and Haemostasis Scientific and standardization commitee on the control of anticoagulation\u2019, Journal of Thrombosis and Haemostasis, 21(5), pp. 1381\u20131384. doi:10.1016\/j.jtha.2023.02.008.<\/p>\n","protected":false},"excerpt":{"rendered":"

\uc2ec\uc7a5 \ubd80\uc804\uc758 \ud608\uc561 \uc751\uace0 \uc7a5\uc560 \uc2ec\uc7a5 \ubd80\uc804(HF)\uc740 \uc2ec\uc7a5\uc758 \uad6c\uc870\uc801 \ub610\ub294 \uae30\ub2a5\uc801 \uc7a5\uc560\ub85c \uc778\ud574 \ubc1c\uc0dd\ud558\ub294 \uc784\uc0c1 \uc99d\ud6c4\uad70\uc73c\ub85c, \uc6b4\ub3d9 \ub610\ub294 \ud734\uc2dd \uc2dc \uc2ec\ub0b4\uc555 \uc0c1\uc2b9 \ubc0f\/\ub610\ub294 \ubd80\uc801\uc808\ud55c \uc2ec\ubc15\ucd9c\ub7c9\uc744 \ucd08\ub798\ud569\ub2c8\ub2e4. \uc774 \uc0c1\ud0dc\ub294 \ub3d9\ub9e5 \ubc0f \uc815\ub9e5 \ud608\uc804\uc99d \uc0ac\uac74\uc758 \uc704\ud5d8 \uc99d\uac00\uc640 \uad00\ub828\uc774 \uc788\uc2b5\ub2c8\ub2e4. \uc784\uc0c1\uc758\ub4e4 \uc0ac\uc774\uc5d0 \uc774 \ubb38\uc81c\uc5d0 \ub300\ud55c \uc778\uc2dd\uc774 \ub192\uc544\uc9c0\uace0, \uc774\ub97c \uad00\ub9ac\ud558\uae30 \uc704\ud55c \ub354 \ub9ce\uc740 \uc5f0\uad6c\uc640 \ub354 \uba85\ud655\ud55c \uac00\uc774\ub4dc\ub77c\uc778\uc774 \uc2ec\uc7a5 \ubd80\uc804 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