{"id":146973,"date":"2019-04-30T03:36:44","date_gmt":"2019-04-30T03:36:44","guid":{"rendered":"https:\/\/labinsights.com\/acf_article\/biotin-la-yeu-to-gay-nhieu-xet-nghiem-can-can-nhac\/"},"modified":"2026-02-16T09:47:24","modified_gmt":"2026-02-16T09:47:24","slug":"putting-biotin-interference-in-context","status":"publish","type":"acf_article","link":"https:\/\/labinsights.com\/vi\/operations\/immunoassay\/putting-biotin-interference-in-context\/","title":{"rendered":"Biotin l\u00e0 y\u1ebfu t\u1ed1 g\u00e2y nhi\u1ec5u x\u00e9t nghi\u1ec7m c\u1ea7n c\u00e2n nh\u1eafc"},"content":{"rendered":"

C\u00e1c chuy\u00ean gia ph\u00f2ng x\u00e9t nghi\u1ec7m b\u1ecb oanh t\u1ea1c b\u1edfi c\u00e1c c\u1ea3nh b\u00e1o nh\u1eb1m ng\u0103n ng\u1eeba x\u1ea3y ra l\u1ed7i ch\u1ea9n \u0111o\u00e1n ho\u1eb7c nhi\u1ec5u x\u00e9t nghi\u1ec7m v\u00e0 \u0111i\u1ec1u \u0111\u00f3 c\u00f3 l\u00fd do ch\u00ednh \u0111\u00e1ng \u2013 l\u1ed7i th\u01b0\u1eddng hay ph\u00e1t sinh trong vi\u1ec7c ch\u0103m s\u00f3c s\u1ee9c kh\u1ecfe. Tuy nhi\u00ean, c\u00e1c ph\u00f2ng x\u00e9t nghi\u1ec7m t\u1ef1 h\u00e0o v\u1ec1 t\u1ef7 l\u1ec7 l\u1ed7i th\u1ea5p h\u01a1n so v\u1edbi ch\u0103m s\u00f3c s\u1ee9c kh\u1ecfe l\u00e2m s\u00e0ng [1]. H\u1ea7u h\u1ebft c\u00e1c l\u1ed7i x\u1ea3y ra (46-68,2% trong s\u1ed1 \u0111\u00f3) \u0111\u1ec1u l\u00e0 ti\u1ec1n ph\u00e2n t\u00edch, ch\u1eb3ng h\u1ea1n nh\u01b0 nh\u1eadp ch\u1ec9 \u0111\u1ecbnh sai, nh\u1eadn \u0111\u01b0\u1ee3c l\u01b0\u1ee3ng m\u1eabu kh\u00f4ng \u0111\u1ee7 ho\u1eb7c d\u00e1n nh\u00e3n m\u1eabu kh\u00f4ng ch\u00ednh x\u00e1c. 18,5-47% s\u1ed1 l\u1ed7i di\u1ec5n ra sau khi \u0111\u00e3 th\u1ef1c hi\u1ec7n x\u00e9t nghi\u1ec7m (v\u00ed d\u1ee5 nh\u01b0 kh\u00f4ng b\u00e1o c\u00e1o k\u1ebft qu\u1ea3). Ch\u1ec9 7-13% trong s\u1ed1 t\u1ea5t c\u1ea3 c\u00e1c l\u1ed7i c\u1ee7a ph\u00f2ng x\u00e9t nghi\u1ec7m b\u1ea3n ch\u1ea5t l\u00e0 v\u1ec1 ph\u00e2n t\u00edch.<\/p>\n

Trong ba giai \u0111o\u1ea1n ch\u00ednh c\u00f3 th\u1ec3 x\u1ea3y ra v\u1ea5n \u0111\u1ec1 trong x\u00e9t nghi\u1ec7m, c\u00e1c l\u1ed7i ph\u00e2n t\u00edch \u2013 bao g\u1ed3m nhi\u1ec5u x\u00e9t nghi\u1ec7m \u2013 \u0111\u01b0\u1ee3c cho l\u00e0 hi\u1ebfm nh\u1ea5t.<\/p>\n

M\u1ed9t s\u1ed1 nguy\u00ean nh\u00e2n ph\u1ed5 bi\u1ebfn nh\u1ea5t c\u1ee7a nhi\u1ec5u x\u00e9t nghi\u1ec7m m\u00e1u l\u00e0 do c\u00e1c v\u1ea5n \u0111\u1ec1 ti\u1ec1n ph\u00e2n t\u00edch, ch\u1eb3ng h\u1ea1n nh\u01b0 v\u1ee1 h\u1ed3ng c\u1ea7u \u1edf m\u1eabu \u2013 l\u00fd do ph\u1ed5 bi\u1ebfn nh\u1ea5t khi\u1ebfn m\u1eabu b\u1ecb t\u1eeb ch\u1ed1i. Ch\u1ec9 ri\u00eang v\u1ea5n \u0111\u1ec1 n\u00e0y c\u0169ng c\u00f3 th\u1ec3 g\u00e2y ra k\u1ebft qu\u1ea3 t\u0103ng gi\u1ea3 tr\u00ean \u00edt nh\u1ea5t m\u1ed9t ch\u1ee5c x\u00e9t nghi\u1ec7m v\u00e0 k\u1ebft qu\u1ea3 gi\u1ea3m gi\u1ea3 tr\u00ean \u00edt nh\u1ea5t n\u0103m x\u00e9t nghi\u1ec7m. M\u1eabu \u0111\u1ee5c do lipid cao (n\u1ed3ng \u0111\u1ed9 ch\u1ea5t b\u00e9o qu\u00e1 m\u1ee9c) v\u00e0 m\u1eabu v\u00e0ng do bilirubin cao (n\u1ed3ng \u0111\u1ed9 bilirubin cao) c\u00f3 th\u1ec3 l\u00e0 v\u1ea5n \u0111\u1ec1 r\u1eafc r\u1ed1i t\u01b0\u01a1ng t\u1ef1 [2].<\/p>\n

\u0110i\u1ec1u quan tr\u1ecdng l\u00e0 \u0111\u00e3 x\u00e1c \u0111\u1ecbnh v\u00e0 hi\u1ec3u \u0111\u01b0\u1ee3c nh\u1eefng ngu\u1ed3n g\u00e2y nhi\u1ec5u ch\u00ednh n\u00e0y. Nh\u01b0ng \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o ch\u00ednh x\u00e1c (v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng), quan tr\u1ecdng l\u00e0 c\u00e1c chuy\u00ean gia ph\u00f2ng x\u00e9t nghi\u1ec7m ph\u1ea3i l\u00e0m quen v\u1edbi nh\u1eefng nguy\u00ean nh\u00e2n g\u00e2y nhi\u1ec5u \u00edt ph\u1ed5 bi\u1ebfn h\u01a1n, ch\u1eb3ng h\u1ea1n nh\u01b0 biotin.<\/p>\n

S\u1ef1 tai ti\u1ebfng c\u1ee7a biotin<\/h2>\n

Sau m\u1ed9t lo\u1ea1t c\u00e1c b\u00e0i vi\u1ebft \u0111\u01b0\u1ee3c b\u00ecnh duy\u1ec7t tr\u00ean t\u1ea1p ch\u00ed ghi l\u1ea1i t\u00ecnh tr\u1ea1ng nhi\u1ec5u x\u00e9t nghi\u1ec7m do biotin, C\u1ee5c Qu\u1ea3n l\u00fd Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m Hoa K\u1ef3 \u0111\u00e3 \u0111\u01b0a ra c\u1ea3nh b\u00e1o v\u00e0o cu\u1ed1i n\u0103m 2017 v\u1ec1 ch\u1ee7 \u0111\u1ec1 n\u00e0y [3]. C\u01a1 quan n\u00e0y hy v\u1ecdng s\u1ebd c\u1ea3i thi\u1ec7n \u0111\u01b0\u1ee3c s\u1ef1 an to\u00e0n v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng x\u00e9t nghi\u1ec7m b\u1eb1ng c\u00e1ch n\u00e2ng cao nh\u1eadn th\u1ee9c sau khi x\u1ea3y ra nhi\u1ec1u tr\u01b0\u1eddng h\u1ee3p k\u1ebft qu\u1ea3 x\u00e9t nghi\u1ec7m kh\u00f4ng ch\u00ednh x\u00e1c \u1edf nh\u1eefng ng\u01b0\u1eddi d\u00f9ng biotin \u1edf m\u1ee9c cao.<\/p>\n

\u1ede m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n, nhi\u1ec5u x\u00e9t nghi\u1ec7m do biotin c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh nhanh ch\u00f3ng, v\u00ec biotin c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c k\u00ea \u0111\u01a1n v\u1edbi li\u1ec1u l\u01b0\u1ee3ng r\u1ea5t l\u1edbn \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb c\u00e1c t\u00ecnh tr\u1ea1ng nh\u01b0 \u0111a x\u01a1 c\u1ee9ng, m\u1eb7c d\u00f9 b\u1ec7nh n\u00e0y hi\u1ebfm g\u1eb7p \u1edf nhi\u1ec1u qu\u1ed1c gia \u1edf Ch\u00e2u \u00c1 v\u00e0 Th\u00e1i B\u00ecnh D\u01b0\u01a1ng. Biotin c\u0169ng l\u00e0 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ti\u00eau chu\u1ea9n cho t\u00ecnh tr\u1ea1ng thi\u1ebfu h\u1ee5t biotin, m\u1ed9t t\u00ecnh tr\u1ea1ng hi\u1ebfm g\u1eb7p tr\u00ean to\u00e0n th\u1ebf gi\u1edbi.<\/p>\n

\u1ede nh\u1eefng b\u1ec7nh nh\u00e2n kh\u00e1c, vi\u1ec7c d\u00f9ng biotin nhi\u1ec1u c\u00f3 th\u1ec3 kh\u00f3 ph\u00e1t hi\u1ec7n ra, v\u00ec m\u1ed9t s\u1ed1 ng\u01b0\u1eddi th\u1eadm ch\u00ed kh\u00f4ng bi\u1ebft h\u1ecd d\u00f9ng ch\u1ea5t n\u00e0y.<\/p>\n

Biotin l\u00e0 m\u1ed9t vitamin tan trong n\u01b0\u1edbc, c\u00f2n \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 vitamin B7 ho\u1eb7c vitamin H. Ch\u1ea5t n\u00e0y c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y trong c\u00e1c vitamin d\u00e0nh cho m\u1eb9 b\u1ea7u, vitamin t\u1ed5ng h\u1ee3p d\u00f9ng h\u00e0ng ng\u00e0y v\u00e0 th\u1ef1c ph\u1ea9m b\u1ed5 sung \u0111\u1ec3 c\u1ea3i thi\u1ec7n t\u00f3c, m\u00f3ng, gan, h\u1ec7 th\u1ea7n kinh v\u00e0 da. Trong t\u1ea5t c\u1ea3 c\u00e1c s\u1ea3n ph\u1ea9m n\u00e0y, biotin c\u00f3 th\u1ec3 hi\u1ec7n di\u1ec7n \u1edf m\u1ee9c \u0111\u1ee7 cao \u0111\u1ec3 g\u00e2y nhi\u1ec5u x\u00e9t nghi\u1ec7m. Li\u1ec1u t\u1eeb 5\u00a0mg m\u1ed7i ng\u00e0y tr\u1edf l\u00ean c\u00f3 th\u1ec3 g\u00e2y nhi\u1ec5u k\u1ebft qu\u1ea3; m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3 d\u00f9ng li\u1ec1u t\u1eeb 20\u00a0mg \u0111\u1ebfn 300\u00a0mg m\u1ed7i ng\u00e0y [3].<\/p>\n

T\u00f9y thu\u1ed9c v\u00e0o lo\u1ea1i x\u00e9t nghi\u1ec7m \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n, biotin d\u01b0 th\u1eeba trong m\u00e1u c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn k\u1ebft qu\u1ea3 cao gi\u1ea3 ho\u1eb7c th\u1ea5p gi\u1ea3. K\u1ebft qu\u1ea3 sai l\u1ec7ch c\u00f3 th\u1ec3 \u0111\u1eb7c bi\u1ec7t \u0111\u00e1ng lo ng\u1ea1i khi ch\u00fang che gi\u1ea5u m\u1ed9t v\u1ea5n \u0111\u1ec1 s\u1ee9c kh\u1ecfe \u0111e d\u1ecda t\u00ednh m\u1ea1ng, ch\u1eb3ng h\u1ea1n nh\u01b0 \u0111au tim. Sai l\u1ec7ch trong k\u1ebft qu\u1ea3 c\u0169ng c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn th\u1ef1c hi\u1ec7n c\u00e1c x\u00e9t nghi\u1ec7m ch\u1ea9n \u0111o\u00e1n kh\u00f4ng c\u1ea7n thi\u1ebft v\u00e0 ch\u0103m s\u00f3c y t\u1ebf kh\u00f4ng ph\u00f9 h\u1ee3p.<\/p>\n

L\u00e0m th\u1ebf n\u00e0o \u0111\u1ec3 ph\u00f2ng x\u00e9t nghi\u1ec7m c\u00f3 th\u1ec3 gi\u1ea3i quy\u1ebft t\u00ecnh tr\u1ea1ng nhi\u1ec5u x\u00e9t nghi\u1ec7m do biotin?<\/h2>\n

Trong m\u1ed9t th\u1ebf gi\u1edbi ho\u00e0n h\u1ea3o, c\u00e1c b\u00e1c s\u0129 ho\u1eb7c k\u1ef9 thu\u1eadt vi\u00ean tr\u00edch m\u00e1u s\u1ebd y\u00eau c\u1ea7u m\u1ecdi b\u1ec7nh nh\u00e2n th\u1ef1c hi\u1ec7n x\u00e9t nghi\u1ec7m xem h\u1ecd c\u00f3 d\u00f9ng biotin trong vitamin ho\u1eb7c ch\u1ea5t b\u1ed5 sung hay kh\u00f4ng, \u1edf m\u1ee9c 5 mg m\u1ed7i ng\u00e0y ho\u1eb7c cao h\u01a1n. Tr\u00ean th\u1ef1c t\u1ebf, c\u00e1c ph\u00f2ng x\u00e9t nghi\u1ec7m s\u1ebd r\u1ea5t may m\u1eafn n\u1ebfu c\u00f3 ai bi\u1ebft v\u1ec1 l\u01b0\u1ee3ng biotin b\u1ec7nh nh\u00e2n s\u1eed d\u1ee5ng (bao g\u1ed3m c\u1ea3 b\u1ec7nh nh\u00e2n).<\/p>\n

M\u1eb7c d\u00f9 \u0111\u00e2y c\u00f3 th\u1ec3 l\u00e0 nguy\u00ean nh\u00e2n \u0111\u00e1ng lo ng\u1ea1i, nh\u01b0ng \u0111\u1ea5y kh\u00f4ng ph\u1ea3i l\u00e0 nguy\u00ean nh\u00e2n g\u00e2y ho\u1ea3ng lo\u1ea1n. Chu\u1ea9n b\u1ecb cho nh\u00f3m c\u1ee7a b\u1ea1n c\u00e1ch x\u1eed l\u00fd kh\u1ea3 n\u0103ng nhi\u1ec5u x\u00e9t nghi\u1ec7m do biotin nh\u01b0 c\u00e1ch b\u1ea1n x\u1eed l\u00fd b\u1ea5t k\u1ef3 t\u00ecnh tr\u1ea1ng nhi\u1ec5u x\u00e9t nghi\u1ec7m n\u00e0o kh\u00e1c li\u00ean quan \u0111\u1ebfn m\u1eabu.<\/p>\n