{"id":146982,"date":"2019-04-30T05:42:31","date_gmt":"2019-04-30T05:42:31","guid":{"rendered":"https:\/\/labinsights.com\/acf_article\/su-phat-trien-cua-cac-cong-nghe-xet-nghiem-truoc-sinh-khong-xam-lan\/"},"modified":"2026-02-17T13:13:05","modified_gmt":"2026-02-17T13:13:05","slug":"the-evolution-of-non-invasive-prenatal-test-technologies","status":"publish","type":"acf_article","link":"https:\/\/labinsights.com\/vi\/operations\/sequencing\/the-evolution-of-non-invasive-prenatal-test-technologies\/","title":{"rendered":"S\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a c\u00e1c c\u00f4ng ngh\u1ec7 x\u00e9t nghi\u1ec7m tr\u01b0\u1edbc sinh kh\u00f4ng x\u00e2m l\u1ea5n"},"content":{"rendered":"

C\u00e1c bu\u1ed5i kh\u00e1m thai tr\u01b0\u1edbc khi sinh th\u01b0\u1eddng l\u00e0 nh\u1eefng d\u1ecbp vui v\u1ebb, nh\u01b0ng nhi\u1ec1u ph\u1ee5 n\u1eef v\u1eabn c\u00f3 ch\u00fat lo l\u1eafng khi m\u1ed7i l\u1ea7n mang thai \u0111\u1ec1u c\u00f3 nguy c\u01a1 c\u00f3 b\u1ea5t th\u01b0\u1eddng nhi\u1ec5m s\u1eafc th\u1ec3. May m\u1eafn thay, nh\u1eefng ti\u1ebfn b\u1ed9 trong c\u00f4ng ngh\u1ec7 x\u00e9t nghi\u1ec7m tr\u01b0\u1edbc sinh kh\u00f4ng x\u00e2m l\u1ea5n (NIPT) l\u00e0m cho qu\u00e1 tr\u00ecnh x\u00e9t nghi\u1ec7m thu\u1eadn ti\u1ec7n v\u00e0 \u0111\u00e1ng tin c\u1eady h\u01a1n bao gi\u1edd h\u1ebft. <\/p>\n

S\u1ef1 gia t\u0103ng c\u1ee7a ph\u00e2n t\u00edch cfDNA cho NIPT<\/h2>\n

K\u1ec3 t\u1eeb khi \u0111\u01b0\u1ee3c gi\u1edbi thi\u1ec7u v\u00e0o nh\u1eefng n\u0103m 1990, x\u00e9t nghi\u1ec7m s\u00e0ng l\u1ecdc k\u1ebft h\u1ee3p trong ba th\u00e1ng \u0111\u1ea7u thai k\u1ef3 (FTS) \u0111\u00e3 l\u00e0 m\u1ed9t c\u00e1ch ti\u1ebfp c\u1eadn ph\u1ed5 bi\u1ebfn \u0111\u1ed1i v\u1edbi x\u00e9t nghi\u1ec7m tr\u01b0\u1edbc sinh. C\u00e1ch ti\u1ebfp c\u1eadn n\u00e0y d\u1ef1a v\u00e0o s\u1ef1 k\u1ebft h\u1ee3p gi\u1eefa t\u00ednh sinh h\u00f3a trong huy\u1ebft thanh v\u00e0\u00a0\u0111\u1ed9 m\u1edd da g\u00e1y c\u1ee7a b\u00e0o thai, \u0111i\u1ec3n h\u00ecnh l\u00e0 t\u1eeb tu\u1ea7n th\u1ee9 11 \u0111\u1ebfn tu\u1ea7n th\u1ee9 13 c\u1ee7a thai k\u1ef3. Ph\u01b0\u01a1ng ph\u00e1p n\u00e0y s\u00e0ng l\u1ecdc m\u1ed9t c\u00e1ch \u0111\u00e1ng tin c\u1eady [1]\u00a0c\u00e1c b\u1ea5t th\u01b0\u1eddng nhi\u1ec5m s\u1eafc th\u1ec3 th\u01b0\u1eddng g\u1eb7p nh\u01b0 h\u1ed9i ch\u1ee9ng Down (tam b\u1ed9i nhi\u1ec5m s\u1eafc th\u1ec3 21) v\u00e0 h\u1ed9i ch\u1ee9ng Edward (tam b\u1ed9i nhi\u1ec5m s\u1eafc th\u1ec3 18). FTS \u0111\u00e3 l\u00e0 m\u1ed9t t\u00e0i s\u1ea3n tuy\u1ec7t v\u1eddi nh\u01b0ng l\u1ea1i \u0111i k\u00e8m v\u1edbi tr\u1ecb s\u1ed1 ti\u00ean \u0111o\u00e1n d\u01b0\u01a1ng t\u00ednh th\u1ea5p v\u00e0 d\u01b0\u01a1ng t\u00ednh gi\u1ea3 cao, theo Bs. Tachjaree Panchale, m\u1ed9t b\u00e1c s\u0129 thu\u1ed9c\u00a0Khoa ph\u1ee5 s\u1ea3n t\u1ea1i Siriraj Hospital \u1edf Th\u00e1i Lan, chia s\u1ebb trong 2018 NIPT Forum Asia.\u00a0FTS \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 \u0111\u1ea1t \u0111\u01b0\u1ee3c t\u1ef7 l\u1ec7 ph\u00e1t hi\u1ec7n 84-90% v\u1edbi t\u1ef7 l\u1ec7 d\u01b0\u01a1ng t\u00ednh gi\u1ea3 l\u00e0 5% [2], t\u1ed1t h\u01a1n kh\u00f4ng c\u00f3 g\u00ec nh\u01b0ng ch\u1eafc ch\u1eafn l\u00e0 kh\u00f4ng t\u1ed1i \u01b0u. Tuy nhi\u00ean, t\u1eeb n\u0103m 2011, nhi\u1ec1u ph\u01b0\u01a1ng ph\u00e1p m\u1edbi \u0111\u00e3 xu\u1ea5t hi\u1ec7n \u0111\u1ec3 th\u00e1ch th\u1ee9c FTS. C\u00e1c ph\u01b0\u01a1ng ph\u00e1p n\u00e0y s\u1ebd s\u00e0ng l\u1ecdc kh\u00f4ng x\u00e2m l\u1ea5n thai nhi \u0111\u1ec3 ph\u00e1t hi\u1ec7n c\u00e1c b\u1ea5t th\u01b0\u1eddng nhi\u1ec5m s\u1eafc th\u1ec3 d\u1ef1a tr\u00ean ph\u00e2n t\u00edch DNA t\u1ef1 do trong m\u00e1u (cfDNA). \u201c[FTS] \u0111\u00e3 \u0111\u01b0\u1ee3c thay th\u1ebf b\u1eb1ng x\u00e9t nghi\u1ec7m DNA t\u1ef1 do trong m\u00e1u\u201d, Gi\u00e1o s\u01b0 Liona Poon, m\u1ed9t Gi\u00e1o s\u01b0 thu\u1ed9c\u00a0Khoa ph\u1ee5 s\u1ea3n t\u1ea1i Chinese University of Hong Kong, cho bi\u1ebft trong c\u00f9ng s\u1ef1 ki\u1ec7n. C\u00e1c m\u1ea3nh DNA c\u1ee7a nhau thai ch\u1ee9a trung b\u00ecnh 13% [3] t\u1ed5ng cfDNA trong m\u00e1u ng\u01b0\u1eddi m\u1eb9. C\u00e1c m\u1ea3nh DNA c\u1ee7a thai nhi c\u00f3 t\u1eeb 150 \u0111\u1ebfn 200 c\u1eb7p baz\u01a1 [4]\u00a0c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y trong m\u00e1u ng\u01b0\u1eddi m\u1eb9 ngay t\u1eeb ng\u00e0y th\u1ee9 32 c\u1ee7a thai k\u1ef3 v\u00e0 t\u0103ng l\u00ean theo th\u1eddi gian [5]. Nh\u1eefng m\u1ea3nh n\u00e0y bi\u1ebfn m\u1ea5t kh\u1ecfi m\u00e1u ng\u01b0\u1eddi m\u1eb9 ch\u1ec9 sau hai gi\u1edd sau khi sinh [3]. Ph\u00e2n t\u00edch cfDNA c\u1ee7a m\u1eb9 v\u00e0 thai nhi cho ph\u00e9p c\u00e1c chuy\u00ean gia y h\u1ecdc x\u00e9t nghi\u1ec7m \u0111\u00e1nh gi\u00e1 thai nhi m\u1ed9t c\u00e1ch ch\u00ednh x\u00e1c v\u00e0 kh\u00f4ng x\u00e2m l\u1ea5n v\u1ec1 b\u1ea5t th\u01b0\u1eddng nhi\u1ec5m s\u1eafc th\u1ec3. C\u00e1c ph\u00f2ng x\u00e9t nghi\u1ec7m c\u00f3 chuy\u00ean m\u00f4n s\u00e2u v\u1ec1 ph\u00e2n t\u00edch cfDNA s\u1ebd \u0111i \u0111\u1ea7u trong c\u00e1c \u1ee9ng d\u1ee5ng m\u1edbi v\u00e0 c\u00f3 th\u1ec3 mang l\u1ea1i gi\u00e1 tr\u1ecb gia t\u0103ng cho c\u00e1c b\u00e1c s\u0129 s\u1ea3n khoa \u0111\u1ed1i t\u00e1c ph\u00eda tr\u01b0\u1edbc xu th\u1ebf. V\u1edbi kh\u1ea3 n\u0103ng ti\u1ebfp c\u1eadn c\u00e1c th\u01b0 vi\u1ec7n tham chi\u1ebfu \u0111\u01b0\u1ee3c x\u00e1c th\u1ef1c ng\u00e0y c\u00e0ng l\u1edbn, \u1ee9ng d\u1ee5ng c\u1ee7a x\u00e9t nghi\u1ec7m cfDNA c\u00f3 kh\u1ea3 n\u0103ng \u0111\u01b0\u1ee3c m\u1edf r\u1ed9ng sang c\u00e1c b\u1ea5t th\u01b0\u1eddng nhi\u1ec5m s\u1eafc th\u1ec3 kh\u00e1c trong t\u01b0\u01a1ng lai. \u201cNh\u00e0 cung c\u1ea5p d\u1ecbch v\u1ee5 ch\u0103m s\u00f3c s\u1ee9c kh\u1ecfe c\u00f3 tr\u00e1ch nhi\u1ec7m c\u1eadp nh\u1eadt c\u00e1c c\u00f4ng c\u1ee5 s\u00e0ng l\u1ecdc hi\u1ec7n c\u00f3 v\u00ec m\u1ed7i ph\u1ee5 n\u1eef \u0111\u1ec1u c\u00f3 quy\u1ec1n t\u1ef1 l\u1ef1a ch\u1ecdn\u201d,\u00a0Bs. Panchalee cho bi\u1ebft th\u00eam. <\/p>\n

Ph\u01b0\u01a1ng ph\u00e1p ti\u1ebfp c\u1eadn cfDNA<\/h2>\n

Gi\u1ed1ng nh\u01b0 b\u1ea5t k\u1ef3 kh\u00e1m ph\u00e1 m\u1edbi n\u00e0o, m\u1ed9t s\u1ed1 ph\u01b0\u01a1ng ph\u00e1p NIPT \u0111ang c\u1ea1nh tranh \u0111\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c ti\u00eau chu\u1ea9n v\u00e0ng. C\u00e1c ph\u01b0\u01a1ng ph\u00e1p n\u00e0y bao g\u1ed3m t\u1eeb gi\u1ea3i tr\u00ecnh t\u1ef1 to\u00e0n b\u1ed9 b\u1ed9 gen v\u00e0 gi\u1ea3i tr\u00ecnh t\u1ef1 nhi\u1ec5m s\u1eafc th\u1ec3 c\u1ee5 th\u1ec3 \u0111\u1ebfn n\u1ec1n t\u1ea3ng d\u1ef1a tr\u00ean x\u00e9t nghi\u1ec7m vi m\u00f4. M\u1ed9t trong nh\u1eefng c\u00f4ng ngh\u1ec7 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng s\u1edbm nh\u1ea5t l\u00e0 gi\u1ea3i tr\u00ecnh t\u1ef1 song song h\u00e0ng lo\u1ea1t (\u201cshotgun\u201d). Ph\u01b0\u01a1ng ph\u00e1p n\u00e0y kh\u00f4ng nh\u1eafm v\u00e0o c\u00e1c v\u00f9ng quan t\u00e2m m\u00e0 \u0111\u00e1nh gi\u00e1 to\u00e0n b\u1ed9 b\u1ed9 gen c\u1ee7a t\u1ea5t c\u1ea3 c\u00e1c m\u1ea3nh cfDNA c\u00f3 trong huy\u1ebft t\u01b0\u01a1ng c\u1ee7a ng\u01b0\u1eddi m\u1eb9. Trong gi\u1ea3i tr\u00ecnh t\u1ef1 to\u00e0n b\u1ed9 b\u1ed9 gen [6], h\u00e0ng ch\u1ee5c tri\u1ec7u \u0111o\u1ea1n \u0111\u1ecdc gi\u1ea3i tr\u00ecnh t\u1ef1 \u0111\u01b0\u1ee3c s\u1eafp x\u1ebfp v\u00e0 l\u1eadp b\u1ea3n \u0111\u1ed3 d\u1ef1a tr\u00ean th\u01b0 vi\u1ec7n tham chi\u1ebfu c\u1ee7a con ng\u01b0\u1eddi \u0111\u1ec3 kh\u1edbp d\u1eef li\u1ec7u thu \u0111\u01b0\u1ee3c v\u1edbi nhi\u1ec5m s\u1eafc th\u1ec3 g\u1ed1c. Sau \u0111\u00f3, d\u1eef li\u1ec7u \u0111\u00e3 l\u1eadp b\u1ea3n \u0111\u1ed3 s\u1ebd \u0111\u01b0\u1ee3c t\u00ednh \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh xem thai nhi c\u00f3 mang b\u1ea5t th\u01b0\u1eddng v\u1ec1 nhi\u1ec5m s\u1eafc th\u1ec3 hay kh\u00f4ng.

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Gi\u1ea3i tr\u00ecnh t\u1ef1 song song h\u00e0ng lo\u1ea1t \u0111\u00e1nh gi\u00e1 to\u00e0n b\u1ed9 b\u1ed9 gen c\u1ee7a t\u1ea5t c\u1ea3 cfDNA trong m\u00e1u ng\u01b0\u1eddi m\u1eb9<\/figcaption><\/figure> \u201cV\u1edbi gi\u1ea3i tr\u00ecnh t\u1ef1 song song h\u00e0ng lo\u1ea1t, c\u1ea7n kho\u1ea3ng 25 tri\u1ec7u danh s\u00e1ch gi\u1ea3i tr\u00ecnh t\u1ef1 th\u00f4 [7]\u00a0cho m\u1ed7i m\u1eabu \u0111\u1ec3 t\u1ea1o ra \u0111\u1ee7 d\u1eef li\u1ec7u cho vi\u1ec7c ph\u00e2n t\u00edch ch\u00ednh x\u00e1c c\u00e1c v\u00f9ng quan t\u00e2m\u201d,\u00a0theo l\u1eddi Bs. Panchalee.\u00a0\u201cPh\u01b0\u01a1ng ph\u00e1p ti\u1ebfp c\u1eadn n\u00e0y \u0111\u1eb7t ra s\u1ef1 d\u01b0 th\u1eeba r\u1ea5t l\u1edbn v\u00ec c\u00e1c nhi\u1ec5m s\u1eafc th\u1ec3 c\u00f3 \u00fd ngh\u0129a l\u00e2m s\u00e0ng ch\u1ec9 chi\u1ebfm 14% b\u1ed9 gen [7].\u201d C\u00e1c c\u00f4ng ngh\u1ec7 m\u1edbi h\u01a1n \u0111ang d\u1ea7n xu\u1ea5t hi\u1ec7n, bao g\u1ed3m c\u00e1c c\u00f4ng ngh\u1ec7 gi\u1ea3i tr\u00ecnh t\u1ef1 b\u00e1n d\u1eabn nh\u01b0 n\u1ec1n t\u1ea3ng Ion Torrent. M\u1eb7c d\u00f9 c\u00f3 m\u1ed9t s\u1ed1 n\u1ec1n t\u1ea3ng t\u1ed3n t\u1ea1i, khi so s\u00e1nh hai c\u00f4ng ngh\u1ec7 nh\u01b0 v\u1eady, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 ph\u00e1t hi\u1ec7n ra r\u1eb1ng [8]\u00a0l\u01b0\u1ee3ng gi\u1ea3i tr\u00ecnh t\u1ef1 v\u00e0 vi\u1ec7c \u00e1p d\u1ee5ng c\u00e1c ph\u00e2n t\u00edch th\u1ed1ng k\u00ea ph\u1ed5 bi\u1ebfn v\u00e0 m\u1ea1nh m\u1ebd c\u00f3 \u00fd ngh\u0129a quan tr\u1ecdng h\u01a1n so v\u1edbi h\u00f3a ch\u1ea5t gi\u1ea3i tr\u00ecnh t\u1ef1 ho\u1eb7c n\u1ec1n t\u1ea3ng c\u1ee5 th\u1ec3 trong vi\u1ec7c \u0111\u1ea3m b\u1ea3o k\u1ebft qu\u1ea3 ch\u00ednh x\u00e1c. G\u1ea7n \u0111\u00e2y h\u01a1n, ph\u00e2n t\u00edch vi m\u1ea3ng \u0111\u00e3 \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng cho x\u00e9t nghi\u1ec7m cfDNA. V\u1edbi \u0111i\u1ec1u n\u00e0y, c\u00e1c v\u00f9ng \u0111\u01b0\u1ee3c ch\u1ecdn c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ph\u00e2n t\u00edch k\u1ef9 thu\u1eadt s\u1ed1 \u0111\u1ec3 t\u00ecm c\u00e1c b\u1ea5t th\u01b0\u1eddng nhi\u1ec5m s\u1eafc th\u1ec3 c\u1ee5 th\u1ec3, bao g\u1ed3m c\u1ea3 tam b\u1ed9i nhi\u1ec5m s\u1eafc th\u1ec3 21, 18, 13 c\u0169ng nh\u01b0 c\u00e1c l\u1ec7ch b\u1ed9i nhi\u1ec5m s\u1eafc th\u1ec3 gi\u1edbi t\u00ednh.
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Ph\u00e2n t\u00edch vi m\u1ea3ng so v\u1edbi gi\u1ea3i tr\u00ecnh t\u1ef1 \u0111\u1ec3 ph\u00e1t hi\u1ec7n ph\u00e2n t\u00edch k\u1ef9 thu\u1eadt s\u1ed1 c\u00e1c v\u00f9ng \u0111\u01b0\u1ee3c ch\u1ecdn<\/figcaption><\/figure> Trong ph\u00e2n t\u00edch \u0111\u1ed1i \u0111\u1ea7u v\u1edbi gi\u1ea3i tr\u00ecnh t\u1ef1 th\u1ebf h\u1ec7 m\u1edbi (NGS), ph\u00e2n t\u00edch vi m\u1ea3ng cho th\u1ea5y k\u1ebft qu\u1ea3 ph\u00e2n t\u00edch cfDNA nhanh h\u01a1n v\u00e0 ch\u00ednh x\u00e1c h\u01a1n [9]\u00a0so v\u1edbi NGS. M\u1ed7i m\u1eabu \u0111\u01b0\u1ee3c ph\u00e2n t\u00edch \u0111\u01a1n m\u1ee5c ti\u00eau \u1edf m\u1ed7i m\u1ea3ng ph\u1ee5, t\u1ea1o ra m\u1ed9t quy tr\u00ecnh ph\u00e2n t\u00edch m\u1eabu \u0111\u01a1n gi\u1ea3n v\u00e0 ti\u1ebft ki\u1ec7m chi ph\u00ed. Ph\u01b0\u01a1ng ph\u00e1p n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c x\u00e1c th\u1ef1c r\u1ed9ng r\u00e3i trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng theo th\u1eddi gian tr\u00ean c\u00e1c qu\u1ea7n th\u1ec3 s\u1ea3n khoa kh\u00e1c nhau. Dr. Panchalee x\u00e1c nh\u1eadn: \u201cVi\u1ec7c x\u00e1c th\u1ef1c n\u1ed9i b\u1ed9 h\u1ec7 th\u1ed1ng \u0111\u00e3 ch\u1ee9ng minh \u0111\u01b0\u1ee3c \u0111\u1ed9 ch\u00ednh x\u00e1c v\u00e0 \u0111\u1ed9 \u0111\u1eb7c hi\u1ec7u cao, kh\u00f4ng c\u00f3 k\u1ebft qu\u1ea3 d\u01b0\u01a1ng t\u00ednh gi\u1ea3 ho\u1eb7c \u00e2m t\u00ednh gi\u1ea3\u201d. C\u00f4ng ngh\u1ec7 m\u1edbi nh\u1ea5t xu\u1ea5t hi\u1ec7n l\u00e0 quy tr\u00ecnh s\u00e1u b\u01b0\u1edbc ch\u1ee5p \u1ea3nh c\u00e1c ph\u00e2n t\u1eed DNA \u0111\u01a1n l\u1ebb [10],\u00a0gi\u00fap gi\u1ea3m \u0111\u1ed9 ph\u1ee9c t\u1ea1p c\u1ee7a x\u00e9t nghi\u1ec7m cfDNA. C\u00f4ng ngh\u1ec7 n\u00e0y k\u1ebft h\u1ee3p c\u00f4ng ngh\u1ec7 th\u0103m d\u00f2 ph\u00e2n t\u1eed m\u1edbi \u0111\u1ec3 g\u1eafn nh\u00e3n nhi\u1ec5m s\u1eafc th\u1ec3 m\u1ee5c ti\u00eau v\u1edbi \u0111\u1ecbnh d\u1ea1ng \u0111\u1ecdc m\u1edbi b\u1eb1ng b\u1ed9 l\u1ecdc nano. \u0110i\u1ec1u n\u00e0y cho ph\u00e9p t\u0103ng sinh c\u00e1c ph\u00e2n t\u1eed \u0111\u01a1n l\u1ebb \u0111\u1ec3 ch\u1ee5p \u1ea3nh v\u00e0 \u0111\u1ebfm m\u00e0 kh\u00f4ng c\u1ea7n vi m\u1ea3ng ho\u1eb7c gi\u1ea3i tr\u00ecnh t\u1ef1 khu\u1ebfch \u0111\u1ea1i DNA. Cho \u0111\u1ebfn nay, c\u00f4ng ngh\u1ec7 n\u00e0y v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c x\u00e1c th\u1ef1c r\u1ed9ng r\u00e3i trong c\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng theo th\u1eddi gian, kh\u00f4ng gi\u1ed1ng nh\u01b0 NGS ho\u1eb7c vi m\u1ea3ng. <\/p>\n

T\u00e1c \u0111\u1ed9ng ti\u1ec1m t\u00e0ng c\u1ee7a cfDNA l\u00e0 g\u00ec?<\/h2>\n

L\u00e0 x\u00e9t nghi\u1ec7m s\u00e0ng l\u1ecdc ch\u1ec9 \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n trong tr\u01b0\u1eddng h\u1ee3p thai k\u1ef3 c\u00f3 nguy c\u01a1 cao ho\u1eb7c trung b\u00ecnh, x\u00e9t nghi\u1ec7m cfDNA \u0111ang thay \u0111\u1ed5i l\u1ef1a ch\u1ecdn c\u1ee7a ph\u1ee5 n\u1eef v\u00e0 gi\u1ea3m th\u1ee7 thu\u1eadt li\u00ean quan \u0111\u1ebfn nguy c\u01a1 s\u1ea3y thai v\u00e0 lo l\u1eafng. M\u1ed9t nghi\u00ean c\u1ee9u v\u1ec1 ph\u1ee5 n\u1eef mang thai \u1edf H\u1ed3ng K\u00f4ng [11] cho th\u1ea5y t\u1ef7 l\u1ec7 x\u00e9t nghi\u1ec7m x\u00e2m l\u1ea5n \u0111\u00e3 gi\u1ea3m \u0111\u00e1ng k\u1ec3 sau khi x\u00e9t nghi\u1ec7m cfDNA \u0111\u01b0\u1ee3c \u0111\u01b0a v\u00e0o s\u1eed d\u1ee5ng. C\u00e1c ph\u00f2ng x\u00e9t nghi\u1ec7m c\u00f3 th\u1ec3 cung c\u1ea5p cho b\u00e1c s\u0129 s\u1ea3n khoa m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p x\u00e9t nghi\u1ec7m kh\u00f4ng x\u00e2m l\u1ea5n kh\u00e1c s\u1ebd gi\u00fap ph\u1ee5 n\u1eef mang thai \u0111\u01b0a ra quy\u1ebft \u0111\u1ecbnh tr\u00ean c\u01a1 s\u1edf \u0111\u01b0\u1ee3c cung c\u1ea5p \u0111\u1ea7y \u0111\u1ee7 th\u00f4ng tin m\u1ed9t c\u00e1ch d\u1ee9t kho\u00e1t h\u01a1n v\u00e0 cu\u1ed1i c\u00f9ng l\u00e0 tr\u00e1nh \u0111\u01b0\u1ee3c c\u00e1c th\u1ee7 thu\u1eadt x\u00e2m l\u1ea5n kh\u00f4ng c\u1ea7n thi\u1ebft. <\/p>\n

\n

T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/em><\/p>\n

[1]<\/a> Malone, D.F., et al., (2005). First-Trimester or Second-Trimester Screening, or Both, for Down’s Syndrome. The New England Journal of Medicine. 353(19), pp.2001-2011. <\/p>\n

[2]<\/a>\u00a0Li, S. W., et al., (2015). The assessment of combined first trimester screening in women of advanced maternal age in an Asian cohort.\u00a0Singapore medical journal,\u00a056(1), pp.47\u201352. <\/p>\n

[3]\u00a0<\/a>Kotsopoulou, I., et al., (2015). Non-invasive prenatal testing (NIPT): limitations on the way to become diagnosis,\u00a0Diagnosis,\u00a02(3), pp.141-158. <\/p>\n

[4]<\/a>\u00a0Taglauer, E. S., et al., (2014). Review: cell-free fetal DNA in the maternal circulation as an indication of placental health and disease.\u00a0Placenta,\u00a035 Suppl(Suppl), S64\u2013S68. <\/p>\n

[5]<\/a> Wataganara, T., et al., (2004). Cell-free fetal DNA levels in maternal plasma after elective first-trimester termination of pregnancy. Fertility and Sterility,\u00a081(3), pp.638-644. <\/p>\n

[6]\u00a0<\/a>Swanson, A., et al.,\u00a0(2013). Non-invasive Prenatal Testing: Technologies, Clinical Assays and Implementation Strategies for Women’s Healthcare Practitioners.\u00a0Current genetic medicine reports,\u00a01(2), pp.113\u2013121. <\/p>\n

[7]\u00a0<\/a>Norwitz, E. R., & Levy, B. (2013). Noninvasive prenatal testing: the future is now.\u00a0Reviews in obstetrics & gynecology,\u00a06(2), pp.48\u201362. <\/p>\n

[8]\u00a0<\/a>Kim, S., et L.,\u00a0(2016). Comparison of two high-throughput semiconductor chip sequencing platforms in noninvasive prenatal testing for Down syndrome in early pregnancy.\u00a0BMC medical genomics,\u00a09(1),\u00a0pp.22. <\/p>\n

[9]<\/a> Juneau, K., et al., (2014). Microarray-Based Cell-Free DNA Analysis Improved Noninvasive Prenatal Testing. Fetal Diagnosis and Therapy, 36, pp.282-286. <\/p>\n

[10]<\/a> Dahl, F., et al., (2018). Imaging single DNA molecules for high precision NIPT. Scientific Reports, 8, 4549. <\/p>\n

[11]<\/a> Cheng YKY., eet al., (2018).\u00a0\u00a0Women\u2019s preference for non-invasive prenatal DNA testing versus chromosomal microarray after screening for Down syndrome: a prospective study. BJOG, 125, pp.451\u2013459. <\/p>\n

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B\u00e0i vi\u1ebft n\u00e0y d\u1ef1a tr\u00ean b\u00e0i thuy\u1ebft tr\u00ecnh \u201cS\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a c\u00f4ng ngh\u1ec7 NIPT ph\u00f9 h\u1ee3p v\u1ec1 m\u1eb7t l\u00e2m s\u00e0ng” v\u00e0 “B\u1eb1ng ch\u1ee9ng c\u1eadp nh\u1eadt v\u00e0 m\u00f4 h\u00ecnh tri\u1ec3n khai x\u00e9t nghi\u1ec7m cfDNA\u201d t\u1ea1i 2018 NIPT Forum Asia \u1edf Bangkok, Th\u00e1i Lan.<\/em><\/p>\n

\n","protected":false},"excerpt":{"rendered":"

C\u00e1c bu\u1ed5i kh\u00e1m thai tr\u01b0\u1edbc khi sinh th\u01b0\u1eddng l\u00e0 nh\u1eefng d\u1ecbp vui v\u1ebb, nh\u01b0ng nhi\u1ec1u ph\u1ee5 n\u1eef v\u1eabn c\u00f3 ch\u00fat lo l\u1eafng khi m\u1ed7i l\u1ea7n mang thai \u0111\u1ec1u c\u00f3 nguy c\u01a1 c\u00f3 b\u1ea5t th\u01b0\u1eddng nhi\u1ec5m s\u1eafc th\u1ec3. May m\u1eafn thay, nh\u1eefng ti\u1ebfn b\u1ed9 trong c\u00f4ng ngh\u1ec7 x\u00e9t nghi\u1ec7m tr\u01b0\u1edbc sinh kh\u00f4ng x\u00e2m l\u1ea5n (NIPT) l\u00e0m […]<\/p>\n","protected":false},"author":1,"featured_media":83573,"parent":0,"menu_order":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"tags":[14754,14778,14795],"pillarandcategory":[326,282,309,288],"reporter":[14797,14796],"class_list":["post-146982","acf_article","type-acf_article","status-publish","has-post-thumbnail","hentry","tag-gia-tri-lam-sang","tag-giai-trinh-tu","tag-suc-khoe-phu-nu","pillarandcategory-sequencing","pillarandcategory-disease-area","pillarandcategory-operations","pillarandcategory-womens-health","reporter-liona-poon","reporter-tachjaree-panchalee"],"acf":[],"_links":{"self":[{"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/acf_article\/146982","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/acf_article"}],"about":[{"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/types\/acf_article"}],"author":[{"embeddable":true,"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":3,"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/acf_article\/146982\/revisions"}],"predecessor-version":[{"id":148801,"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/acf_article\/146982\/revisions\/148801"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/media\/83573"}],"wp:attachment":[{"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/media?parent=146982"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/tags?post=146982"},{"taxonomy":"pillarandcategory","embeddable":true,"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/pillarandcategory?post=146982"},{"taxonomy":"reporter","embeddable":true,"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/reporter?post=146982"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}