{"id":147161,"date":"2023-01-10T07:13:35","date_gmt":"2023-01-10T07:13:35","guid":{"rendered":"https:\/\/labinsights.com\/acf_article\/huyet-khoi-trong-ung-thu-va-viem-goc-nhin-tu-giao-su-ng-heng-joo\/"},"modified":"2026-01-27T08:59:10","modified_gmt":"2026-01-27T08:59:10","slug":"thrombosis-in-cancer-and-inflammation-insights-from-prof-ng-heng-joo","status":"publish","type":"acf_article","link":"https:\/\/labinsights.com\/vi\/disease-area\/coagulation\/thrombosis-in-cancer-and-inflammation-insights-from-prof-ng-heng-joo\/","title":{"rendered":"Huy\u1ebft kh\u1ed1i trong ung th\u01b0 v\u00e0 vi\u00eam: g\u00f3c nh\u00ecn t\u1eeb Gi\u00e1o s\u01b0 Ng Heng Joo"},"content":{"rendered":"

T\u1ea1i pro-COAG<\/a>, m\u1ed9t s\u1ef1 ki\u1ec7n khoa h\u1ecdc v\u00e0 gi\u00e1o d\u1ee5c th\u01b0\u1eddng ni\u00ean v\u1ec1 \u0111\u00f4ng m\u00e1u do Roche Diagnostics t\u00e0i tr\u1ee3 \u0111\u01b0\u1ee3c t\u1ed5 ch\u1ee9c l\u1ea7n g\u1ea7n nh\u1ea5t v\u00e0o th\u00e1ng 3 n\u0103m 2022, Gi\u00e1o s\u01b0 Ng Heng Joo, Tr\u01b0\u1edfng khoa Huy\u1ebft h\u1ecdc t\u1ea1i B\u1ec7nh vi\u1ec7n \u0110a khoa Singapore \u1edf Singapore, \u0111\u00e3 xem x\u00e9t nguy\u00ean nh\u00e2n, qu\u00e1 tr\u00ecnh ph\u00e1t tri\u1ec3n v\u00e0 \u0111i\u1ec1u tr\u1ecb c\u00e1c bi\u1ebfn c\u1ed1 huy\u1ebft kh\u1ed1i t\u0129nh m\u1ea1ch trong ung th\u01b0 v\u00e0 vi\u00eam.<\/p>\n

Ung th\u01b0<\/h2>\n

T\u1ea7n su\u1ea5t c\u1ee7a c\u00e1c bi\u1ebfn c\u1ed1 huy\u1ebft kh\u1ed1i trong ung th\u01b0 \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng th\u1ef1c r\u00f5, \u0111\u1eb7c bi\u1ec7t l\u00e0 huy\u1ebft kh\u1ed1i t\u0129nh m\u1ea1ch (VTEs) c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb huy\u1ebft kh\u1ed1i t\u0129nh m\u1ea1ch s\u00e2u chi d\u01b0\u1edbi (DVT), chi\u1ebfm 0,6 \u0111\u1ebfn 7,8% tr\u01b0\u1eddng h\u1ee3p. Huy\u1ebft kh\u1ed1i t\u0129nh m\u1ea1ch g\u1ea7n v\u00e0 huy\u1ebft kh\u1ed1i \u0111\u1ed9ng m\u1ea1ch \u0111\u1ea1i di\u1ec7n cho nguy c\u01a1 c\u1ee5 th\u1ec3 do c\u00f3 khuynh h\u01b0\u1edbng g\u00e2y ra thuy\u00ean t\u1eafc ph\u1ed5i (PE) v\u00e0 \u0111\u1ed9t qu\u1ef5 t\u01b0\u01a1ng \u1ee9ng. Do \u0111\u00f3, \u0111i\u1ec1u quan tr\u1ecdng l\u00e0 ph\u1ea3i hi\u1ec3u \u0111\u01b0\u1ee3c c\u00e1c c\u01a1 ch\u1ebf huy\u1ebft kh\u1ed1i li\u00ean quan \u0111\u1ebfn b\u1ec7nh \u00e1c t\u00ednh, c\u00f9ng v\u1edbi c\u00e1c y\u1ebfu t\u1ed1 nguy c\u01a1 kh\u00e1c, \u0111\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c k\u1ebft qu\u1ea3 \u0111i\u1ec1u tr\u1ecb t\u1ed1i \u01b0u.<\/p>\n

T\u00ecnh tr\u1ea1ng t\u0103ng \u0111\u00f4ng li\u00ean quan \u0111\u1ebfn kh\u1ed1i u l\u00e0 k\u1ebft qu\u1ea3 c\u1ee7a ba c\u01a1 ch\u1ebf t\u01b0\u01a1ng t\u00e1c: ph\u00e1 h\u1ee7y n\u1ed9i m\u00f4, ho\u1ea1t \u0111\u1ed9ng ti\u1ec1n huy\u1ebft kh\u1ed1i c\u1ee7a c\u00e1c t\u1ebf b\u00e0o \u00e1c t\u00ednh v\u00e0 bi\u1ec3u hi\u1ec7n ti\u1ec1n \u0111\u00f4ng m\u00e1u c\u1ee7a v\u1eadt ch\u1ee7. C\u1ea3 hai c\u01a1 ch\u1ebf tr\u00ean c\u01a1 s\u1edf kh\u1ed1i u v\u00e0 v\u1eadt ch\u1ee7 t\u1eadp trung v\u00e0o vi\u1ec7c k\u00edch ho\u1ea1t chu\u1ed7i \u0111\u00f4ng m\u00e1u n\u1ed9i sinh do m\u00f4 v\u00e0 c\u00e1c y\u1ebfu t\u1ed1 \u0111\u00f4ng m\u00e1u, \u0111\u01b0\u1ee3c bi\u1ec3u hi\u1ec7n tr\u1ef1c ti\u1ebfp ho\u1eb7c k\u00edch th\u00edch b\u1edfi kh\u1ed1i u v\u00e0 ti\u1ec3u c\u1ea7u. N\u1ed9i m\u00f4 b\u1ecb t\u1ed5n th\u01b0\u01a1ng c\u00f3 th\u1ec3 l\u00e0 do can thi\u1ec7p \u0111i\u1ec1u tr\u1ecb ho\u1eb7c t\u00ednh th\u1ea5m m\u1ea1ch m\u00e1u do vi\u00eam.<\/p>\n

C\u00f3 th\u1ec3 d\u1ef1 \u0111o\u00e1n \u0111\u01b0\u1ee3c r\u1eb1ng, c\u00e1c kh\u1ed1i u \u00e1c t\u00ednh \u1edf giai \u0111o\u1ea1n ti\u1ebfn tri\u1ec3n v\u00e0 c\u00e1c kh\u1ed1i u \u00e1c t\u00ednh \u1edf c\u00e1c c\u01a1 quan c\u00f3 nhi\u1ec1u m\u1ea1ch m\u00e1u c\u00f3 nguy c\u01a1 huy\u1ebft kh\u1ed1i cao nh\u1ea5t. C\u00e1c y\u1ebfu t\u1ed1 nguy c\u01a1 c\u1ee7a b\u1ec7nh nh\u00e2n (v\u00ed d\u1ee5 nh\u01b0 tu\u1ed5i t\u00e1c), t\u00ecnh tr\u1ea1ng kh\u00f4ng v\u1eadn \u0111\u1ed9ng, g\u00e1nh n\u1eb7ng b\u1ec7nh t\u1eadt \u0111i k\u00e8m v\u00e0 \u0111\u1eb7c t\u00ednh g\u00e2y huy\u1ebft kh\u1ed1i v\u1ed1n c\u00f3 c\u1ee7a c\u00e1c t\u00e1c nh\u00e2n h\u00f3a tr\u1ecb li\u1ec7u c\u00f3 th\u1ec3 l\u00e0m t\u0103ng cao t\u00ecnh tr\u1ea1ng n\u00e0y. Khuy\u1ebfn c\u00e1o ph\u00f2ng ng\u1eeba huy\u1ebft kh\u1ed1i (b\u1eb1ng c\u00e1ch u\u1ed1ng thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng tr\u1ef1c ti\u1ebfp v\u00e0 heparin tr\u1ecdng l\u01b0\u1ee3ng ph\u00e2n t\u1eed th\u1ea5p) cho t\u1ea5t c\u1ea3 b\u1ec7nh nh\u00e2n ung th\u01b0 nh\u1eadp vi\u1ec7n v\u00e0 c\u00f3 nguy c\u01a1 cao ho\u1eb7c trung b\u00ecnh, \u0111\u00e1nh gi\u00e1 b\u1eb1ng c\u00e1c c\u00f4ng c\u1ee5 nh\u01b0 \u0111i\u1ec3m Khorana v\u00e0 c\u00e1c c\u00f4ng c\u1ee5 ph\u00e1i sinh [1].<\/p>\n

Vi\u00eam<\/h2>\n

M\u1eb7c d\u00f9 k\u1ebft qu\u1ea3 t\u01b0\u01a1ng t\u1ef1 nhau nh\u01b0ng huy\u1ebft kh\u1ed1i b\u1ec7nh l\u00fd do ph\u1ea3n \u1ee9ng c\u1ee7a h\u1ec7 mi\u1ec5n d\u1ecbch v\u1edbi nhi\u1ec5m tr\u00f9ng ho\u1eb7c ch\u1ea5t k\u00edch ho\u1ea1t vi\u00eam d\u1ef1a tr\u00ean huy\u1ebft kh\u1ed1i mi\u1ec5n d\u1ecbch sinh l\u00fd qu\u00e1 m\u1ee9c. Qu\u00e1 tr\u00ecnh n\u00e0y bao g\u1ed3m vi\u1ec7c \u0111i\u1ec1u h\u00f2a t\u0103ng c\u00e1c th\u1ee5 th\u1ec3 interleukin v\u00e0 c\u00e1c ph\u00e2n t\u1eed b\u00e1m d\u00ednh tr\u00ean th\u00e0nh m\u1ea1ch, s\u1ef1 b\u00e1m d\u00ednh c\u1ee7a b\u1ea1ch c\u1ea7u trung t\u00ednh v\u00e0o n\u1ed9i m\u00f4 m\u1ea1ch m\u00e1u, ho\u1ea1t h\u00f3a c\u00e1c t\u1ebf b\u00e0o \u0111\u01a1n nh\u00e2n v\u00e0 bi\u1ec3u hi\u1ec7n c\u00e1c y\u1ebfu t\u1ed1 m\u00f4, v\u00e0 kh\u1edfi \u0111\u1ea7u chu\u1ed7i ph\u1ea3n \u1ee9ng \u0111\u00f4ng m\u00e1u d\u1eabn \u0111\u1ebfn ho\u1ea1t h\u00f3a b\u1ea1ch c\u1ea7u trung t\u00ednh \u0111\u1ec3 t\u1ea1o ra b\u1eaby ngo\u1ea1i b\u00e0o b\u1ea1ch c\u1ea7u trung t\u00ednh (NETosis) t\u1ea1o th\u00e0nh n\u1ec1n t\u1ea3ng huy\u1ebft kh\u1ed1i.<\/p>\n

M\u1eb7c d\u00f9 ph\u00f2ng ng\u1eeba huy\u1ebft kh\u1ed1i l\u00e0 \u0111i\u1ec1u c\u1ea7n thi\u1ebft \u0111\u1ed1i v\u1edbi c\u00e1c tr\u01b0\u1eddng h\u1ee3p nhi\u1ec5m tr\u00f9ng c\u00f3 th\u1ec3 g\u00e2y ra tr\u1ea1ng th\u00e1i \u0111\u00f4ng m\u00e1u qu\u00e1 m\u1ee9c (v\u00ed d\u1ee5: COVID-19) nh\u01b0ng huy\u1ebft kh\u1ed1i g\u00e2y vi\u00eam kh\u00f4ng nh\u1ea5t thi\u1ebft ph\u1ea3i \u0111\u00e1p \u1ee9ng v\u1edbi li\u1ec7u ph\u00e1p ch\u1ed1ng \u0111\u00f4ng m\u00e1u, v\u00e0 c\u00f3 th\u1ec3 s\u1ebd \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb hi\u1ec7u qu\u1ea3 h\u01a1n b\u1eb1ng c\u00e1c thu\u1ed1c ch\u1ed1ng vi\u00eam. Cu\u1ed9c tranh lu\u1eadn v\u1eabn \u0111ang ti\u1ebfp di\u1ec5n.<\/p>\n

Gi\u00e1o s\u01b0 Ng Heng Joo, MD l\u00e0 Chuy\u00ean gia t\u01b0 v\u1ea5n c\u1ea5p cao ki\u00eam Tr\u01b0\u1edfng Khoa Huy\u1ebft h\u1ecdc t\u1ea1i B\u1ec7nh vi\u1ec7n \u0110a khoa Singapore; Gi\u00e1o s\u01b0 L\u00e2m s\u00e0ng t\u1ea1i Tr\u01b0\u1eddng Y khoa \u0110\u1ea1i h\u1ecdc Duke-National University of Singapore (NUS); v\u00e0 Gi\u1ea3ng vi\u00ean Cao c\u1ea5p t\u1ea1i Tr\u01b0\u1eddng Y khoa Yong Loo Lin c\u1ee7a NUS.<\/em><\/p>\n

T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/p>\n

[1]<\/a> Lee, LH, et al. Front \u00a0Cardiovasc Med, 2021;8:669288<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u1ea1i pro-COAG, m\u1ed9t s\u1ef1 ki\u1ec7n khoa h\u1ecdc v\u00e0 gi\u00e1o d\u1ee5c th\u01b0\u1eddng ni\u00ean v\u1ec1 \u0111\u00f4ng m\u00e1u do Roche Diagnostics t\u00e0i tr\u1ee3 \u0111\u01b0\u1ee3c t\u1ed5 ch\u1ee9c l\u1ea7n g\u1ea7n nh\u1ea5t v\u00e0o th\u00e1ng 3 n\u0103m 2022, Gi\u00e1o s\u01b0 Ng Heng Joo, Tr\u01b0\u1edfng khoa Huy\u1ebft h\u1ecdc t\u1ea1i B\u1ec7nh vi\u1ec7n \u0110a khoa Singapore \u1edf Singapore, \u0111\u00e3 xem x\u00e9t nguy\u00ean nh\u00e2n, qu\u00e1 tr\u00ecnh […]<\/p>\n","protected":false},"author":1,"featured_media":85636,"parent":0,"menu_order":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"tags":[14793,14776],"pillarandcategory":[292,282,287],"reporter":[15001],"class_list":["post-147161","acf_article","type-acf_article","status-publish","has-post-thumbnail","hentry","tag-dong-mau","tag-ung-thu-hoc","pillarandcategory-coagulation","pillarandcategory-disease-area","pillarandcategory-oncology","reporter-ng-heng-joo"],"acf":[],"_links":{"self":[{"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/acf_article\/147161","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/acf_article"}],"about":[{"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/types\/acf_article"}],"author":[{"embeddable":true,"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":1,"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/acf_article\/147161\/revisions"}],"predecessor-version":[{"id":147679,"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/acf_article\/147161\/revisions\/147679"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/media\/85636"}],"wp:attachment":[{"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/media?parent=147161"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/tags?post=147161"},{"taxonomy":"pillarandcategory","embeddable":true,"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/pillarandcategory?post=147161"},{"taxonomy":"reporter","embeddable":true,"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/reporter?post=147161"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}