V\u1edbi nh\u1eefng ti\u1ebfn b\u1ed9 g\u1ea7n \u0111\u00e2y trong kh\u1ea3 n\u0103ng ph\u00e2n t\u00edch v\u00e0 hi\u1ec3u bi\u1ebft v\u1ec1 h\u1ec7 vi sinh v\u1eadt \u0111\u01b0\u1eddng ru\u1ed9t c\u1ee7a con ng\u01b0\u1eddi, c\u00e1c nh\u00e0 khoa h\u1ecdc y t\u1ebf \u0111ang c\u00f3 nh\u1eefng hi\u1ec3u bi\u1ebft \u0111\u1ea7y h\u1ee9ng kh\u1edfi v\u1ec1 c\u00e1ch m\u00e0 h\u1ec7 sinh th\u00e1i vi sinh v\u1eadt trong \u0111\u01b0\u1eddng ti\u00eau h\u00f3a \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ee9c kh\u1ecfe con ng\u01b0\u1eddi\u2014t\u1eeb s\u1ee9c kh\u1ecfe \u0111\u01b0\u1eddng ru\u1ed9t cho \u0111\u1ebfn h\u1ea7u h\u1ebft m\u1ecdi kh\u00eda c\u1ea1nh c\u1ee7a s\u1ee9c kh\u1ecfe v\u00e0 s\u1ef1 ph\u00e1t tri\u1ec3n to\u00e0n di\u1ec7n.<\/p>\n
Nh\u1eefng hi\u1ec3u bi\u1ebft n\u00e0y hi\u1ec7n \u0111ang m\u1edf ra con \u0111\u01b0\u1eddng cho c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi, bao g\u1ed3m c\u00e1c lo\u1ea1i thu\u1ed1c ch\u00ednh x\u00e1c \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf ri\u00eang cho c\u1ea5u tr\u00fac vi sinh v\u1eadt \u0111\u1ed9c \u0111\u00e1o c\u1ee7a t\u1eebng c\u00e1 nh\u00e2n, c\u00f9ng v\u1edbi c\u00e1c d\u1ecbch v\u1ee5 v\u00e0 c\u00f4ng ngh\u1ec7 x\u00e9t nghi\u1ec7m l\u00e2m s\u00e0ng s\u1ebd h\u1eefu \u00edch cho c\u1ea3 nghi\u00ean c\u1ee9u v\u00e0 ch\u0103m s\u00f3c l\u00e2m s\u00e0ng.<\/p>\n
L\u00e0 ng\u01b0\u1eddi \u0111\u1ed3ng s\u00e1ng l\u1eadp ki\u00eam CEO c\u1ee7a AMILI<\/a>, l\u00e0 c\u00f4ng ty \u0111\u1ea7u ti\u00ean t\u1ea1i \u0110\u00f4ng Nam \u00c1 chuy\u00ean v\u1ec1 microbiome \u0111\u01b0\u1eddng ru\u1ed9t ch\u00ednh x\u00e1c, B\u00e1c s\u0129 Jeremy Lim \u0111ang d\u1eabn \u0111\u1ea7u c\u00e1c n\u1ed7 l\u1ef1c mang nghi\u00ean c\u1ee9u h\u1ec7 vi sinh v\u1eadt \u0111\u1ebfn khu v\u1ef1c Ch\u00e2u \u00c1 \u2014 Th\u00e1i B\u00ecnh D\u01b0\u01a1ng v\u00e0 m\u1edf r\u1ed9ng kh\u1ea3 n\u0103ng ti\u1ebfp c\u1eadn c\u00e1c d\u1ecbch v\u1ee5 h\u1ec7 vi sinh v\u1eadt ph\u00f9 h\u1ee3p v\u1edbi c\u00e1c nh\u00f3m d\u00e2n s\u1ed1 ch\u00e2u \u00c1.<\/p>\n Lab Insights g\u1ea7n \u0111\u00e2y \u0111\u00e3 tr\u00f2 chuy\u1ec7n v\u1edbi B\u00e1c s\u0129 Lim \u0111\u1ec3 t\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00e1ch \u00f4ng b\u1eaft \u0111\u1ea7u nghi\u00ean c\u1ee9u v\u1ec1 h\u1ec7 vi sinh v\u1eadt v\u00e0 nh\u1eefng k\u1ebf ho\u1ea1ch \u0111ang ch\u1edd \u0111\u00f3n trong t\u01b0\u01a1ng lai. M\u1eb7c d\u00f9 c\u00f4ng ty c\u1ee7a \u00f4ng v\u00e0 l\u0129nh v\u1ef1c khoa h\u1ecdc h\u1ec7 vi sinh v\u1eadt c\u00f2n kh\u00e1 m\u1edbi m\u1ebb, nh\u01b0ng nh\u1eefng xu h\u01b0\u1edbng n\u00e0y c\u00f3 th\u1ec3 s\u1ebd c\u00f3 nh\u1eefng t\u00e1c \u0111\u1ed9ng ng\u00e0y c\u00e0ng l\u1edbn \u0111\u1ed1i v\u1edbi y h\u1ecdc x\u00e9t nghi\u1ec7m trong nh\u1eefng n\u0103m t\u1edbi.<\/p>\n Tr\u01b0\u1edbc khi s\u00e1ng l\u1eadp AMILI, B\u00e1c s\u0129 Jeremy Lim \u0111\u00e3 c\u00f3 m\u1ed9t s\u1ef1 nghi\u1ec7p l\u00e2u d\u00e0i v\u00e0 \u0111\u00e1ng ch\u00fa \u00fd trong l\u0129nh v\u1ef1c y h\u1ecdc v\u00e0 y t\u1ebf c\u1ed9ng \u0111\u1ed3ng. M\u1eb7c d\u00f9 v\u1eady, kh\u00e1i ni\u1ec7m v\u1ec1 h\u1ec7 vi sinh v\u1eadt v\u00e0 nh\u1eefng t\u00e1c \u0111\u1ed9ng c\u1ee7a n\u00f3 kh\u00f4ng th\u1ef1c s\u1ef1 xu\u1ea5t hi\u1ec7n trong t\u1ea7m nh\u00ecn c\u1ee7a \u00f4ng cho \u0111\u1ebfn th\u1eddi gian g\u1ea7n \u0111\u00e2y.<\/p>\n \u00d4ng chia s\u1ebb: \u201cV\u00e0o n\u0103m n\u0103m tr\u01b0\u1edbc, t\u00f4i kh\u00f4ng bi\u1ebft \u0111\u1ebfn thu\u1eadt ng\u1eef \u201ch\u1ec7 vi sinh v\u1eadt\u201d, nh\u01b0ng gi\u1edd \u0111\u00e2y \u0111\u00f3 l\u00e0 l\u0129nh v\u1ef1c th\u00fa v\u1ecb nh\u1ea5t \u0111\u1ed1i v\u1edbi t\u00f4i\u201d. V\u00e0o kho\u1ea3ng n\u0103m 2019, B\u00e1c s\u0129 David Ong v\u00e0 B\u00e1c s\u0129 Jonathan Lee\u2014c\u00e1c nh\u00e0 \u0111\u1ed3ng s\u00e1ng l\u1eadp c\u1ee7a AMILI, khi \u0111\u00f3 \u0111\u1ec1u \u0111ang c\u00f4ng t\u00e1c t\u1ea1i B\u1ec7nh vi\u1ec7n \u0110\u1ea1i h\u1ecdc Qu\u1ed1c gia Singapore (NUH)\u2014\u0111\u00e3 ch\u1ec9 ra v\u1edbi \u00f4ng v\u1ec1 t\u00ecnh tr\u1ea1ng khoa h\u1ecdc h\u1ec7 vi sinh v\u1eadt v\u00e0 nh\u1eefng nghi\u00ean c\u1ee9u n\u1ed5i b\u1eadt \u0111ang \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n \u1edf \u00a0B\u1eafc M\u1ef9 v\u00e0 Ch\u00e2u \u00c2u.<\/p>\n B\u00e1c s\u0129 Ong v\u00e0 Lee l\u00e0 m\u1ed9t ph\u1ea7n c\u1ee7a \u0111\u1ed9i ng\u0169 t\u1ea1i NUH \u0111\u00e3 th\u1ef1c hi\u1ec7n ca c\u1ea5y gh\u00e9p h\u1ec7 vi sinh v\u1eadt \u0111\u1ea7u ti\u00ean \u1edf khu v\u1ef1c v\u00e0o n\u0103m 2014. Tuy nhi\u00ean, k\u1ec3 t\u1eeb \u0111\u00f3, t\u1ed1c \u0111\u1ed9 nghi\u00ean c\u1ee9u v\u00e0 ph\u00e1t hi\u1ec7n v\u1ec1 h\u1ec7 vi sinh v\u1eadt \u1edf Singapore v\u00e0 \u0110\u00f4ng Nam \u00c1 v\u1eabn c\u00f2n kh\u00e1 khi\u00eam t\u1ed1n. Ba ng\u01b0\u1eddi cu\u1ed1i c\u00f9ng \u0111\u00e3 th\u00e0nh l\u1eadp AMILI \u0111\u1ec3 \u0111\u01b0a c\u00f4ng vi\u1ec7c n\u00e0y \u0111\u1ebfn Ch\u00e2u \u00c1 Th\u00e1i B\u00ecnh D\u01b0\u01a1ng.<\/p>\n B\u00e1c s\u0129 Lim h\u1ed3i t\u01b0\u1edfng: \u201cCh\u00fang t\u00f4i nh\u1eadn ra t\u1ea7m quan tr\u1ecdng c\u1ee7a c\u00e1c gi\u1ea3i ph\u00e1p \u0111\u1ecba ph\u01b0\u01a1ng v\u00e0 khu v\u1ef1c, v\u00e0 th\u1ea5y r\u1eb1ng r\u1ea5t \u00edt c\u00f4ng vi\u1ec7c \u0111ang \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n, \u0111\u1eb7c bi\u1ec7t l\u00e0 \u1edf khu v\u1ef1c ch\u00e2u \u00c1 \u0111a d\u00e2n t\u1ed9c.\u201d \u201cCh\u00fang t\u00f4i quy\u1ebft \u0111\u1ecbnh r\u1eb1ng, m\u1eb7c d\u00f9 l\u00e0 nh\u1eefng gi\u00e1o s\u01b0 \u0111\u1ea1i h\u1ecdc \u201ckhoa h\u1ecdc\u201d, vi\u1ec7c th\u00e0nh l\u1eadp m\u1ed9t doanh nghi\u1ec7p kh\u1edfi nghi\u1ec7p l\u00e0 c\u00e1ch nhanh nh\u1ea5t v\u00e0 linh ho\u1ea1t nh\u1ea5t \u0111\u1ec3 thay \u0111\u1ed5i \u0111i\u1ec1u n\u00e0y.\u201d<\/p>\n B\u00ean c\u1ea1nh c\u00f4ng vi\u1ec7c t\u1ea1i AMILI, B\u00e1c s\u0129 Lim v\u1eabn gi\u1eef ch\u1ee9c v\u1ee5 Gi\u00e1m \u0111\u1ed1c Vi\u1ec7n L\u00e3nh \u0111\u1ea1o v\u1ec1 Chuy\u1ec3n \u0111\u1ed5i S\u1ee9c kh\u1ecfe To\u00e0n c\u1ea7u t\u1ea1i Tr\u01b0\u1eddng Y t\u1ebf C\u00f4ng c\u1ed9ng Saw Swee Hock, thu\u1ed9c \u0110\u1ea1i h\u1ecdc Qu\u1ed1c gia Singapore. \u00d4ng c\u0169ng vi\u1ebft b\u00e0i v\u00e0 gi\u1ea3ng b\u00e0i th\u01b0\u1eddng xuy\u00ean v\u1ec1 c\u00e1c ch\u1ee7 \u0111\u1ec1 s\u1ee9c kh\u1ecfe c\u1ed9ng \u0111\u1ed3ng (xem b\u00e0i thuy\u1ebft tr\u00ecnh n\u1ed5i ti\u1ebfng c\u1ee7a \u00f4ng v\u1ec1 RED 2021 ch\u1ee7 \u0111\u1ec1 Precision Public Health <\/a>m\u1ed9t v\u00ed d\u1ee5 trong s\u1ed1 nhi\u1ec1u s\u00e1ng ki\u1ebfn m\u00e0 \u00f4ng \u0111ang d\u1eabn d\u1eaft).<\/p>\n Tuy nhi\u00ean, khi AMILI ng\u00e0y c\u00e0ng ph\u00e1t tri\u1ec3n, \u00f4ng \u0111ang t\u1eadp trung nhi\u1ec1u h\u01a1n v\u00e0o h\u1ec7 vi sinh v\u1eadt nh\u01b0 m\u1ed9t l\u0129nh v\u1ef1c then ch\u1ed1t m\u00e0 \u00f4ng d\u1ef1 \u0111\u1ecbnh s\u1ebd t\u1ea1o ra \u1ea3nh h\u01b0\u1edfng m\u1ea1nh m\u1ebd.<\/p>\n AMILI \u0111\u01b0\u1ee3c th\u00e0nh l\u1eadp d\u1ef1a tr\u00ean ti\u1ec1n \u0111\u1ec1 r\u1eb1ng h\u1ec7 vi sinh v\u1eadt \u0111\u01b0\u1eddng ru\u1ed9t c\u1ee7a ng\u01b0\u1eddi\u2014t\u1eadp h\u1ee3p c\u00e1c vi khu\u1ea9n, vi-r\u00fat v\u00e0 n\u1ea5m c\u01b0 tr\u00fa trong ru\u1ed9t v\u00e0 c\u00e1c b\u1ed9 ph\u1eadn kh\u00e1c c\u1ee7a \u0111\u01b0\u1eddng ti\u00eau h\u00f3a\u2014n\u1eafm gi\u1eef ch\u00eca kh\u00f3a cho nhi\u1ec1u kh\u00eda c\u1ea1nh ti\u1ec1m n\u0103ng c\u1ee7a s\u1ee9c kh\u1ecfe con ng\u01b0\u1eddi.<\/p>\n V\u1edbi s\u1ef1 ra \u0111\u1eddi v\u00e0 t\u00ednh kh\u1ea3 d\u1ee5ng ng\u00e0y c\u00e0ng t\u0103ng c\u1ee7a rRNA 16S c\u1ee7a vi khu\u1ea9n v\u00e0 gi\u1ea3i tr\u00ecnh t\u1ef1 shotgun (s\u00e2u h\u01a1n v\u00e0 to\u00e0n di\u1ec7n h\u01a1n), nghi\u00ean c\u1ee9u v\u1ec1 h\u1ec7 vi sinh v\u1eadt \u0111\u00e3 b\u00f9ng n\u1ed5 trong nh\u1eefng n\u0103m g\u1ea7n \u0111\u00e2y. Nghi\u00ean c\u1ee9u \u0111\u00e3 cho th\u1ea5y s\u1ef1 \u0111a d\u1ea1ng \u0111\u00e1ng kinh ng\u1ea1c c\u1ee7a h\u1ec7 vi sinh v\u1eadt \u0111\u01b0\u1eddng ru\u1ed9t \u1edf m\u1ed7i c\u00e1 nh\u00e2n. C\u00e1c \u01b0\u1edbc t\u00ednh cho th\u1ea5y ch\u00fang ta ch\u1ec9 chia s\u1ebb 20\u201430% h\u1ec7 vi sinh v\u1eadt, tr\u00e1i ng\u01b0\u1ee3c v\u1edbi 99,9% gen.<\/p>\n Nghi\u00ean c\u1ee9u v\u1ec1 h\u1ec7 vi sinh v\u1eadt c\u0169ng cho th\u1ea5y h\u1ec7 vi sinh v\u1eadt \u1ea3nh h\u01b0\u1edfng m\u1ea1nh m\u1ebd \u0111\u1ebfn s\u1ee9c kh\u1ecfe nh\u01b0 th\u1ebf n\u00e0o v\u00e0 c\u00f3 th\u1ec3 li\u00ean quan \u0111\u1ebfn b\u1ec7nh t\u1eadt. H\u1ec7 vi sinh v\u1eadt t\u00e1c \u0111\u1ed9ng \u0111\u1ebfn qu\u00e1 tr\u00ecnh trao \u0111\u1ed5i ch\u1ea5t, ch\u1eb3ng h\u1ea1n nh\u01b0 d\u1eabn \u0111\u1ebfn s\u1ef1 h\u1ea5p th\u1ee5 \u0111\u01b0\u1eddng huy\u1ebft r\u1ea5t kh\u00e1c nhau gi\u1eefa nh\u1eefng c\u1eb7p song sinh gi\u1ed1ng h\u1ec7t nhau [1]. H\u1ec7 vi sinh v\u1eadt \u0111i\u1ec1u ch\u1ec9nh h\u1ec7 th\u1ed1ng n\u1ed9i ti\u1ebft [2], h\u00e0nh vi [3] v\u00e0 h\u1ec7 mi\u1ec5n d\u1ecbch [4] v\u00e0 li\u00ean quan \u0111\u1ebfn s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a b\u1ec7nh tho\u00e1i h\u00f3a th\u1ea7n kinh [5].<\/p>\n Do t\u00e1c \u0111\u1ed9ng n\u00e0y, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u v\u00e0 b\u00e1c s\u0129 l\u00e2m s\u00e0ng ng\u00e0y c\u00e0ng quan t\u00e2m \u0111\u1ebfn vi\u1ec7c s\u1eed d\u1ee5ng h\u1ec7 vi sinh v\u1eadt \u0111\u1ec3 \u0111i\u1ec1u ch\u1ec9nh ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb [6,7]. M\u1ed9t nghi\u00ean c\u1ee9u mang t\u00ednh b\u01b0\u1edbc ngo\u1eb7t v\u00e0o n\u0103m 2013 c\u0169ng \u0111\u00e3 ch\u1ee9ng minh l\u1ee3i \u00edch c\u1ee7a vi\u1ec7c truy\u1ec1n vi sinh v\u1eadt trong ph\u00e2n (FMT) \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb nhi\u1ec5m clostridium difficile t\u00e1i ph\u00e1t [8]. Qu\u00e1 tr\u00ecnh FMT, bao g\u1ed3m vi\u1ec7c chuy\u1ec3n ph\u00e2n ng\u01b0\u1eddi cho kh\u1ecfe m\u1ea1nh sang ng\u01b0\u1eddi c\u00f3 t\u00ecnh tr\u1ea1ng n\u00e0y, d\u01b0\u1eddng nh\u01b0 c\u0169ng c\u00f3 ti\u1ec7n \u00edch cho nhi\u1ec1u t\u00ecnh tr\u1ea1ng s\u1ee9c kh\u1ecfe kh\u00e1c.<\/p>\n Lim l\u01b0u \u00fd: \u201cH\u1ec7 vi sinh v\u1eadt \u0111\u01b0\u1eddng ru\u1ed9t tr\u1edf th\u00e0nh n\u01a1i r\u1ea5t t\u1ef1 nhi\u00ean \u0111\u1ec3 ch\u00fang ta b\u1eaft \u0111\u1ea7u t\u1ef1 h\u1ecfi l\u00e0m th\u1ebf n\u00e0o \u0111\u1ec3 c\u00e1 nh\u00e2n h\u00f3a th\u1ef1c ph\u1ea9m, th\u1ef1c ph\u1ea9m b\u1ed5 sung v\u00e0 thu\u1ed1c \u0111\u1ec3 t\u1ed1i \u01b0u h\u00f3a s\u1ee9c kh\u1ecfe t\u1ed1t\u201d. \u00d4ng cho r\u1eb1ng trong t\u01b0\u01a1ng lai g\u1ea7n, ch\u00fang ta c\u00f3 th\u1ec3 k\u1ebft h\u1ee3p \u0111\u01b0\u1ee3c h\u1ec7 vi sinh v\u1eadt c\u1ee7a ng\u01b0\u1eddi hi\u1ebfn t\u1eb7ng v\u00e0 ng\u01b0\u1eddi nh\u1eadn, gi\u1ed1ng nh\u01b0 c\u00e1ch ch\u00fang ta l\u00e0m hi\u1ec7n nay \u0111\u1ed1i v\u1edbi c\u1ea5y gh\u00e9p t\u1ebf b\u00e0o g\u1ed1c v\u00e0 c\u00e1c th\u1ee7 thu\u1eadt kh\u00e1c.<\/p>\n V\u1edbi s\u1ef1 hi\u1ec3u bi\u1ebft ng\u00e0y c\u00e0ng t\u0103ng, FMT th\u1eadm ch\u00ed c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn nh\u1eefng ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb \u0111\u1ed9t ph\u00e1 cho c\u00e1c c\u0103n b\u1ec7nh tr\u01b0\u1edbc \u0111\u00e2y ch\u01b0a \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t t\u1ed1t. V\u00ed d\u1ee5, B\u00e1c s\u0129 Lim v\u00e0 c\u00e1c \u0111\u1ed3ng nghi\u1ec7p \u0111\u00e3 c\u00f4ng b\u1ed1 m\u1ed9t nghi\u00ean c\u1ee9u tr\u01b0\u1eddng h\u1ee3p n\u1ed5i b\u1eadt v\u1ec1 m\u1ed9t b\u1ec7nh nh\u00e2n m\u1eafc ADHD kh\u00f4ng c\u00f2n tri\u1ec7u ch\u1ee9ng sau FMT [9].<\/p>\n AMILI \u0111\u1eb7t m\u1ee5c ti\u00eau x\u00e2y d\u1ef1ng m\u1ed9t th\u01b0 vi\u1ec7n \u0111\u1ea7y \u0111\u1ee7 v\u1ec1 h\u1ec7 vi khu\u1ea9n \u0111\u01b0\u1eddng ru\u1ed9t \u1edf Ch\u00e2u \u00c1, th\u00fac \u0111\u1ea9y nghi\u00ean c\u1ee9u v\u00e0 m\u1edf r\u1ed9ng kh\u1ea3 n\u0103ng ti\u1ebfp c\u1eadn c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb nh\u01b0 FMT trong khu v\u1ef1c. Hi\u1ec7n t\u1ea1i, d\u1ecbch v\u1ee5 n\u00e0y \u0111ang cung c\u1ea5p cho Singapore, Malaysia v\u00e0 Th\u00e1i Lan v\u00e0 s\u1ebd s\u1edbm tri\u1ec3n khai t\u1ea1i Philippines, Vi\u1ec7t Nam v\u00e0 H\u1ed3ng K\u00f4ng.<\/p>\n V\u00e0o th\u00e1ng 7 n\u0103m 2022, c\u00f4ng ty \u0111\u00e3 huy \u0111\u1ed9ng \u0111\u01b0\u1ee3c 10,5 tri\u1ec7u \u0111\u00f4 la trong v\u00f2ng t\u00e0i tr\u1ee3 Series A do nh\u00e0 \u0111\u1ea7u t\u01b0 khoa h\u1ecdc \u0111\u1eddi s\u1ed1ng v\u00e0 c\u00f4ng ngh\u1ec7 Vulcan Capital (nay g\u1ecdi l\u00e0 Cercano Management), m\u1ed9t qu\u1ef9 \u0111\u01b0\u1ee3c th\u00e0nh l\u1eadp b\u1edfi ng\u01b0\u1eddi \u0111\u1ed3ng s\u00e1ng l\u1eadp Microsoft qu\u00e1 c\u1ed1 Paul Allen. Trong s\u1ed1 c\u00e1c nh\u00e0 \u0111\u1ea7u t\u01b0 tham gia n\u00e0y c\u00f3 Emtek Group, Capital Code, Pureland Group, Blue7, Pruksa Group, TVM Capital Healthcare v\u00e0 c\u00f4ng ty \u0111\u1ea7u t\u01b0 SEEDS Capital c\u1ee7a Enterprise Singapore [10,11]. \u0110i\u1ec1u n\u00e0y \u0111\u00e3 th\u00fac \u0111\u1ea9y s\u1ef1 t\u0103ng tr\u01b0\u1edfng c\u1ee7a c\u00f4ng ty. AMILI hi\u1ec7n c\u00f3 30 nh\u00e2n vi\u00ean \u1edf 4 qu\u1ed1c gia.<\/p>\n AMILI c\u0169ng \u0111ang h\u1ee3p t\u00e1c v\u1edbi Trung t\u00e2m Ung th\u01b0 Qu\u1ed1c gia Singapore trong m\u1ed9t nghi\u00ean c\u1ee9u \u0111o\u00e0n h\u1ec7 l\u1edbn nh\u1eb1m x\u00e1c \u0111\u1ecbnh c\u00e1c y\u1ebfu t\u1ed1 d\u1ef1 b\u00e1o ung th\u01b0 gan b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng ph\u01b0\u01a1ng ph\u00e1p l\u1ea5y m\u1eabu vi sinh v\u1eadt theo chi\u1ec1u d\u1ecdc k\u1ebft h\u1ee3p v\u1edbi c\u00e1c thu\u1eadt to\u00e1n h\u1ecdc m\u00e1y [12]. B\u00e1c s\u0129 Lim hy v\u1ecdng k\u1ebft qu\u1ea3 c\u1ee7a nghi\u00ean c\u1ee9u n\u00e0y s\u1ebd gi\u00fap c\u1ed9ng \u0111\u1ed3ng y khoa hi\u1ec3u r\u00f5 h\u01a1n v\u1ec1 h\u1ec7 vi sinh v\u1eadt \u0111\u01b0\u1eddng ru\u1ed9t.<\/p>\n Tuy nhi\u00ean, vi\u1ec7c mang nh\u1eefng \u0111\u1ed5i m\u1edbi n\u00e0y \u0111\u1ebfn Ch\u00e2u \u00c1 v\u00e0 nh\u1eefng qu\u1ed1c gia kh\u00e1c s\u1ebd kh\u00f4ng ph\u1ea3i l\u00e0 kh\u00f4ng c\u00f3 th\u00e1ch th\u1ee9c.<\/p>\n Tr\u01b0\u1edbc h\u1ebft, vi\u1ec7c hi\u1ec3u \u0111\u01b0\u1ee3c h\u1ec7 vi sinh v\u1eadt \u0111\u01b0\u1eddng ru\u1ed9t kh\u00f4ng ph\u1ea3i l\u00e0 nhi\u1ec7m v\u1ee5 d\u1ec5 d\u00e0ng. Bao g\u1ed3m kho\u1ea3ng 100 ngh\u00ecn t\u1ef7 t\u1ebf b\u00e0o vi khu\u1ea9n, h\u1ec7 vi sinh v\u1eadt \u0111\u01b0\u1eddng ru\u1ed9t c\u1ef1c k\u1ef3 \u0111a d\u1ea1ng, v\u01b0\u1ee3t xa s\u1ed1 l\u01b0\u1ee3ng t\u1ebf b\u00e0o trong c\u01a1 th\u1ec3 ng\u01b0\u1eddi. V\u00e0 v\u1edbi h\u01a1n 1000 lo\u00e0i ch\u1ee9a h\u00e0ng tri\u1ec7u gen, n\u00f3 l\u00e0m lu m\u1edd s\u1ef1 ph\u1ee9c t\u1ea1p c\u1ee7a b\u1ed9 gen con ng\u01b0\u1eddi.<\/p>\n B\u00e1c s\u0129 Lim c\u0169ng l\u01b0u \u00fd r\u1eb1ng l\u0129nh v\u1ef1c n\u00e0y v\u1eabn \u0111ang n\u1ed7 l\u1ef1c x\u00e1c \u0111\u1ecbnh ch\u00ednh x\u00e1c \u0111i\u1ec1u g\u00ec t\u1ea1o n\u00ean h\u1ec7 vi sinh v\u1eadt \u0111\u01b0\u1eddng ru\u1ed9t kh\u1ecfe m\u1ea1nh. Nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng di truy\u1ec1n, ch\u1ebf \u0111\u1ed9 \u0103n u\u1ed1ng, m\u00f4i tr\u01b0\u1eddng, th\u00f3i quen v\u00e0 th\u1eadm ch\u00ed c\u1ea3 vi\u1ec7c ti\u1ebfp x\u00fac v\u1edbi c\u00e1c y\u1ebfu t\u1ed1 v\u00e0 h\u00e0nh vi x\u00e3 h\u1ed9i \u0111\u1ec1u c\u00f3 t\u00e1c \u0111\u1ed9ng \u0111\u1ebfn c\u1ea5u t\u1ea1o c\u1ee7a n\u00f3. \u0110i\u1ec1u n\u00e0y l\u00e0m t\u0103ng th\u00eam s\u1ef1 ph\u1ee9c t\u1ea1p trong vi\u1ec7c t\u00ecm hi\u1ec3u.<\/p>\n B\u00e1c s\u0129 Lim c\u0169ng th\u1eeba nh\u1eadn r\u1eb1ng s\u1ebd m\u1ea5t th\u1eddi gian \u0111\u1ec3 vi sinh v\u1eadt h\u1ecdc \u0111\u01b0\u1ee3c c\u00f4ng nh\u1eadn r\u1ed9ng r\u00e3i tr\u00ean l\u00e2m s\u00e0ng, bao g\u1ed3m c\u1ea3 vi\u1ec7c b\u1ed5 sung v\u00e0o ch\u01b0\u01a1ng tr\u00ecnh gi\u1ea3ng d\u1ea1y y khoa. B\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3 kh\u00f4ng mu\u1ed1n tham gia v\u00e0o c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb vi sinh v\u1eadt h\u1ecdc do s\u1ef1 k\u1ef3 th\u1ecb xung quanh c\u00e1c ch\u1ee7 \u0111\u1ec1 nh\u1ea1y c\u1ea3m nh\u01b0 l\u1ea5y m\u1eabu ph\u00e2n v\u00e0 FMT. Kinh ph\u00ed \u0111\u1ea7u t\u01b0 cho c\u00e1c ho\u1ea1t \u0111\u1ed9ng nghi\u00ean c\u1ee9u v\u00e0 th\u01b0\u01a1ng m\u1ea1i, tuy \u0111\u01b0\u1ee3c c\u1ea3i thi\u1ec7n nhi\u1ec1u trong nh\u1eefng n\u0103m g\u1ea7n \u0111\u00e2y, v\u1eabn c\u00f2n h\u1ea1n ch\u1ebf.<\/p>\n Tuy nhi\u00ean, theo th\u1eddi gian, l\u0129nh v\u1ef1c n\u00e0y c\u00f3 th\u1ec3 s\u1ebd \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn r\u1ed9ng r\u00e3i h\u01a1n \u1edf Ch\u00e2u \u00c1, \u0111\u1eb7c bi\u1ec7t n\u1ebfu nh\u1eefng ti\u1ebfn b\u1ed9 trong nghi\u00ean c\u1ee9u v\u1ec1 h\u1ec7 vi sinh v\u1eadt mang l\u1ea1i nhi\u1ec1u ph\u00e1t hi\u1ec7n h\u01a1n d\u1eabn \u0111\u1ebfn c\u00e1c bi\u1ec7n ph\u00e1p can thi\u1ec7p \u0111\u01b0\u1ee3c x\u00e1c nh\u1eadn l\u00e2m s\u00e0ng. \u0110i\u1ec1u n\u00e0y s\u1ebd m\u1edf ra c\u00e1nh c\u1eeda cho c\u00e1c d\u1ecbch v\u1ee5 m\u1edbi m\u00e0 c\u00e1c ph\u00f2ng x\u00e9t nghi\u1ec7m l\u00e2m s\u00e0ng c\u00f3 th\u1ec3 cung c\u1ea5p.<\/p>\n V\u00ed d\u1ee5, b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng thu\u1ed1c l\u00e2u d\u00e0i ho\u1eb7c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng nhi\u1ec1u lo\u1ea1i thu\u1ed1c, cu\u1ed1i c\u00f9ng c\u00f3 th\u1ec3 c\u00f3 h\u1ed3 s\u01a1 h\u1ec7 vi sinh v\u1eadt c\u1ee7a h\u1ecd th\u01b0\u1eddng xuy\u00ean \u0111\u01b0\u1ee3c gi\u1ea3i tr\u00ecnh t\u1ef1 \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh xem h\u1ecd l\u00e0 nh\u1eefng ng\u01b0\u1eddi \u0111\u00e1p \u1ee9ng t\u1ed1t hay k\u00e9m. V\u1edbi nhi\u1ec1u ph\u00e2n t\u00edch h\u01a1n n\u1eefa, ch\u00fang ta c\u00f3 th\u1ec3 t\u1ed1i \u01b0u h\u00f3a ho\u1eb7c th\u1eadm ch\u00ed d\u1ef1 \u0111o\u00e1n \u0111\u01b0\u1ee3c ph\u00e1c \u0111\u1ed3 \u0111i\u1ec1u tr\u1ecb t\u1ed1t nh\u1ea5t.<\/p>\n M\u1eb7c d\u00f9 c\u00f4ng ngh\u1ec7 gi\u1ea3i tr\u00ecnh t\u1ef1 \u0111\u00e3 \u0111\u01b0\u1ee3c th\u01b0\u01a1ng m\u1ea1i h\u00f3a t\u01b0\u01a1ng \u0111\u1ed1i, vi\u1ec7c t\u00e1ch chi\u1ebft nguy\u00ean li\u1ec7u di truy\u1ec1n vi sinh t\u1eeb c\u00e1c m\u1eabu ph\u00e2n r\u1ea5t ph\u1ee9c t\u1ea1p v\u00e0 c\u1ea7n m\u1ed9t quy tr\u00ecnh t\u00e1ch chi\u1ebft nghi\u00eam ng\u1eb7t. \u201cTrong AMILI, ch\u00fang t\u00f4i \u0111\u00e3 th\u1eed nghi\u1ec7m nhi\u1ec1u k\u1ef9 thu\u1eadt chi\u1ebft xu\u1ea5t v\u00e0 cu\u1ed1i c\u00f9ng \u0111\u00e3 ph\u00e1t tri\u1ec3n k\u1ef9 thu\u1eadt ri\u00eang c\u1ee7a m\u00ecnh, sau \u0111\u00f3 ch\u00fang t\u00f4i th\u1eed nghi\u1ec7m \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 hi\u1ec7u su\u1ea5t gi\u1ea3i tr\u00ecnh t\u1ef1.\u201d<\/p>\n Ngo\u00e0i ra c\u00f2n c\u00f3 nhi\u1ec1u c\u01a1 h\u1ed9i \u0111\u1ed5i m\u1edbi trong vi\u1ec7c l\u1ea5y v\u00e0 x\u1eed l\u00fd m\u1eabu b\u00ean c\u1ea1nh vi\u1ec7c ph\u00e2n t\u00edch c\u00e1c tr\u00ecnh t\u1ef1. B\u00e1c s\u0129 Lim tin r\u1eb1ng c\u1ea7n ph\u1ea3i c\u00f3 nhi\u1ec1u nghi\u00ean c\u1ee9u h\u01a1n n\u1eefa \u0111\u1ec3 ho\u00e0n thi\u1ec7n qu\u00e1 tr\u00ecnh n\u00e0y.<\/p>\n B\u00e1c s\u0129 Lim n\u00f3i: \u201cG\u1eedi t\u1ea5t c\u1ea3 c\u00e1c ph\u00f2ng x\u00e9t nghi\u1ec7m, khi tham gia v\u00e0o l\u0129nh v\u1ef1c h\u1ec7 vi sinh v\u1eadt, h\u00e3y ch\u00fa \u00fd \u0111\u1ebfn quy tr\u00ecnh chi\u1ebft xu\u1ea5t.\u201d \u201cN\u1ebfu kh\u00f4ng, k\u1ebft qu\u1ea3 c\u1ee7a b\u1ea1n s\u1ebd c\u00f3 tr\u00ean to\u00e0n b\u1ed9 b\u1ea3n \u0111\u1ed3\u201d.<\/p>\n T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/em><\/p>\n [1]<\/a> Berry, S.E., Valdes, A.M., Drew, D.A. et al. Human postprandial responses to food and potential for precision nutrition. Nat Med 26, 964\u2013973 (2020). doi.org\/10.1038\/s41591-020-0934-0 (https:\/\/www.forbes.com\/sites\/annahaines\/2021\/07\/23\/this-diet-is-changing-the-way-we-think-about-nutrition\/?sh=3c2d0211312a)<\/p>\n [2]<\/a> Williams CL, Garcia-Reyero N, Martyniuk CJ, Tubbs CW, Bisesi JH Jr. Regulation of endocrine systems by the microbiome: Perspectives from comparative animal models. Gen Comp Endocrinol. 2020 Jun 1;292:113437. doi: 10.1016\/j.ygcen.2020.113437. Epub 2020 Feb 12. PMID: 32061639.<\/p>\n [3]<\/a> Soca\u0142a K, Doboszewska U, Szopa A, Serefko A, W\u0142odarczyk M, Zieli\u0144ska A, Poleszak E, Fichna J, Wla\u017a P. The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders. Pharmacol Res. 2021 Oct;172:105840. doi: 10.1016\/j.phrs.2021.105840. Epub 2021 Aug 24. PMID: 34450312.<\/p>\n [4]<\/a> Wastyk HC, Fragiadakis GK, Perelman D, Dahan D, Merrill BD, Yu FB, Topf M, Gonzalez CG, Van Treuren W, Han S, Robinson JL, Elias JE, Sonnenburg ED, Gardner CD, Sonnenburg JL. Gut-microbiota-targeted diets modulate human immune status. Cell. 2021 Aug 5;184(16):4137-4153.e14. doi: 10.1016\/j.cell.2021.06.019. Epub 2021 Jul 12. PMID: 34256014; PMCID: PMC9020749.<\/p>\n [5]<\/a> Fang P, Kazmi SA, Jameson KG, Hsiao EY. The Microbiome as a Modifier of Neurodegenerative Disease Risk. Cell Host Microbe. 2020 Aug 12;28(2):201-222. doi: 10.1016\/j.chom.2020.06.008. PMID: 32791113; PMCID: PMC7430034.<\/p>\n [6]<\/a> Lee JWJ, Plichta D, Hogstrom L, Borren NZ, Lau H, Gregory SM, Tan W, Khalili H, Clish C, Vlamakis H, Xavier RJ, Ananthakrishnan AN. Multi-omics reveal microbial determinants impacting responses to biologic therapies in inflammatory bowel disease. Cell Host Microbe. 2021 Aug 11;29(8):1294-1304.e4. doi: 10.1016\/j.chom.2021.06.019. Epub 2021 Jul 22. PMID: 34297922; PMCID: PMC8366279.<\/p>\n [7]<\/a> Javdan B, Lopez JG, Chankhamjon P, Lee YJ, Hull R, Wu Q, Wang X, Chatterjee S, Donia MS. Personalized Mapping of Drug Metabolism by the Human Gut Microbiome. Cell. 2020 Jun 25;181(7):1661-1679.e22. doi: 10.1016\/j.cell.2020.05.001. Epub 2020 Jun 10. PMID: 32526207; PMCID: PMC8591631.<\/p>\n [8]<\/a> Terveer EM, Vendrik KE, Ooijevaar RE, Lingen EV, Boeije-Koppenol E, Nood EV, Goorhuis A, Bauer MP, van Beurden YH, Dijkgraaf MG, Mulder CJ, Vandenbroucke-Grauls CM, Seegers JF, van Prehn J, Verspaget HW, Kuijper EJ, Keller JJ. Faecal microbiota transplantation for Clostridioides difficile infection: Four years’ experience of the Netherlands Donor Feces Bank. United European Gastroenterol J. 2020 Dec;8(10):1236-1247. doi: 10.1177\/2050640620957765. Epub 2020 Sep 29. PMID: 32990503; PMCID: PMC7724536.<\/p>\n [9]<\/a> Hooi SL, Dwiyanto J, Rasiti H, Toh KY, Wong RKM, Lee JWJ. A case report of improvement on ADHD symptoms after fecal microbiota transplantation with gut microbiome profiling pre- and post-procedure. Curr Med Res Opin. 2022 Nov;38(11):1977-1982. doi:10.1080\/03007995.2022.2129232. Epub 2022 Oct 7. PMID: 36164761.<\/p>\n [10]<\/a> https:\/\/www.amili.asia\/media\/<\/p>\nT\u1eeb m\u1ed9t chuy\u00ean gia y t\u1ebf c\u1ed9ng \u0111\u1ed3ng \u0111\u1ebfn ng\u01b0\u1eddi s\u00e1ng l\u1eadp kh\u1edfi nghi\u1ec7p<\/h2>\n
T\u1ea1i sao h\u1ec7 vi sinh v\u1eadt \u0111\u01b0\u1eddng ru\u1ed9t l\u1ea1i quan tr\u1ecdng?<\/h2>\n
H\u1ec7 vi sinh v\u1eadt \u0111\u01b0\u1eddng ru\u1ed9t ch\u00ednh x\u00e1c \u2013 do ng\u01b0\u1eddi ch\u00e2u \u00c1 th\u1ef1c hi\u1ec7n, d\u00e0nh cho ng\u01b0\u1eddi ch\u00e2u \u00c1<\/h2>\n
\u00dd ngh\u0129a \u0111\u1ed1i v\u1edbi ph\u00f2ng x\u00e9t nghi\u1ec7m h\u1ec7 vi sinh v\u1eadt l\u00e2m s\u00e0ng<\/h2>\n