{"id":147168,"date":"2023-06-01T01:53:26","date_gmt":"2023-06-01T01:53:26","guid":{"rendered":"https:\/\/labinsights.com\/acf_article\/cac-dau-an-sinh-hoc-moi-cua-vi-rut-viem-gan-b-hbv-ho-tro-no-luc-giam-tai-vi-rut\/"},"modified":"2026-01-27T10:02:19","modified_gmt":"2026-01-27T10:02:19","slug":"new-hbv-biomarkers-support-virus-reduction-efforts","status":"publish","type":"acf_article","link":"https:\/\/labinsights.com\/vi\/operations\/immunoassay\/new-hbv-biomarkers-support-virus-reduction-efforts\/","title":{"rendered":"C\u00e1c d\u1ea5u \u1ea5n sinh h\u1ecdc m\u1edbi c\u1ee7a vi-r\u00fat vi\u00eam gan B (HBV) h\u1ed7 tr\u1ee3 n\u1ed7 l\u1ef1c gi\u1ea3m t\u1ea3i vi-r\u00fat"},"content":{"rendered":"

Trong b\u1ed1i c\u1ea3nh c\u00e1c n\u1ed7 l\u1ef1c y t\u1ebf to\u00e0n c\u1ea7u ng\u00e0y c\u00e0ng t\u0103ng nh\u1eb1m gi\u1ea3m t\u1ef7 l\u1ec7 t\u1eed vong do vi\u00eam gan B (HBV), c\u00e1c nh\u00e0 l\u00e3nh \u0111\u1ea1o trong l\u0129nh v\u1ef1c ph\u00f2ng x\u00e9t nghi\u1ec7m v\u00e0 ch\u0103m s\u00f3c s\u1ee9c kh\u1ecfe tr\u00ean kh\u1eafp th\u1ebf gi\u1edbi \u0111ang ph\u00e1t tri\u1ec3n v\u00e0 tri\u1ec3n khai c\u00e1c d\u1ea5u \u1ea5n sinh h\u1ecdc m\u1edbi \u0111\u1ec3 h\u01b0\u1edbng d\u1eabn c\u00e1c chi\u1ebfn l\u01b0\u1ee3c ch\u0103m s\u00f3c. Trong m\u1ed9t h\u1ed9i th\u1ea3o tr\u1ef1c tuy\u1ebfn g\u1ea7n \u0111\u00e2y do Roche Diagnostics t\u1ed5 ch\u1ee9c, hai chuy\u00ean gia vi-r\u00fat h\u1ecdc \u0111\u1ebfn t\u1eeb \u00dac \u0111\u00e3 tr\u00ecnh b\u00e0y v\u1ec1 nh\u1eefng ti\u1ebfn b\u1ed9 m\u1edbi nh\u1ea5t trong ch\u1ea9n \u0111o\u00e1n HBV v\u00e0 kh\u1ea3 n\u0103ng s\u1eed d\u1ee5ng ch\u00fang trong n\u01b0\u1edbc.<\/p>\n

D\u01b0\u1edbi \u0111\u00e2y l\u00e0 m\u1ed9t s\u1ed1 \u0111i\u1ec3m ch\u00ednh t\u1eeb bu\u1ed5i h\u1ed9i th\u1ea3o tr\u1ef1c tuy\u1ebfn, v\u1edbi c\u00e1c b\u00e0i thuy\u1ebft tr\u00ecnh t\u1eeb Gi\u00e1o s\u01b0 Alex Thompson, Gi\u00e1o s\u01b0 ki\u00eam Gi\u00e1m \u0111\u1ed1c Khoa Ti\u00eau h\u00f3a t\u1ea1i B\u1ec7nh vi\u1ec7n St Vincent\u2019s, \u0110\u1ea1i h\u1ecdc Melbourne, v\u00e0 Ph\u00f3 Gi\u00e1o s\u01b0 Mark Douglas, Ph\u00f3 Gi\u00e1o s\u01b0 t\u1ea1i \u0110\u1ea1i h\u1ecdc Sydney v\u00e0 Trung t\u00e2m Gan Storr, Vi\u1ec7n Nghi\u00ean c\u1ee9u Y khoa Westmead, Australia.<\/p>\n

T\u1ea7m quan tr\u1ecdng c\u1ee7a vi\u1ec7c gi\u1ea3m t\u1ef7 l\u1ec7 HBV<\/h2>\n

V\u1edbi 2 t\u1ef7 ng\u01b0\u1eddi tr\u00ean to\u00e0n c\u1ea7u \u0111\u00e3 t\u1eebng m\u1eafc vi\u00eam gan B (HBV) v\u00e0o m\u1ed9t th\u1eddi \u0111i\u1ec3m n\u00e0o \u0111\u00f3 trong cu\u1ed9c \u0111\u1eddi v\u00e0 300 tri\u1ec7u ng\u01b0\u1eddi m\u1eafc c\u00e1c b\u1ec7nh nhi\u1ec5m tr\u00f9ng m\u1ea1n t\u00ednh, HBV l\u00e0 m\u1ed9t th\u00e1ch th\u1ee9c l\u1edbn \u0111\u1ed1i v\u1edbi s\u1ee9c kh\u1ecfe to\u00e0n c\u1ea7u. N\u1ebfu kh\u00f4ng \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb, c\u00f3 \u0111\u1ebfn 40% s\u1ed1 b\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3 ch\u1ebft v\u00ec x\u01a1 gan ho\u1eb7c ung th\u01b0 gan do vi-r\u00fat g\u00e2y ra.<\/p>\n

\u0110\u00e2y l\u00e0 l\u00fd do t\u1ea1i sao c\u00e1c c\u01a1 quan y t\u1ebf c\u00f4ng c\u1ed9ng \u0111\u00e3 nh\u1eafm \u0111\u1ebfn HBV trong m\u1ed9t chi\u1ebfn d\u1ecbch l\u1edbn \u0111\u1ec3 gi\u1ea3m ho\u1eb7c lo\u1ea1i b\u1ecf vi-r\u00fat. N\u0103m 2016, T\u1ed5 ch\u1ee9c Y t\u1ebf Th\u1ebf gi\u1edbi c\u00f4ng b\u1ed1 k\u1ebf ho\u1ea1ch<\/a> gi\u1ea3m 90% s\u1ed1 ca nhi\u1ec5m HBV v\u00e0 \u0111\u1ebfn n\u0103m 2030 s\u1ed1 ca t\u1eed vong gi\u1ea3m 65%. K\u1ebf ho\u1ea1ch n\u00e0y t\u1eadp trung v\u00e0o vi\u1ec7c ng\u0103n ch\u1eb7n l\u00e2y truy\u1ec1n t\u1eeb m\u1eb9 sang con tr\u01b0\u1edbc ho\u1eb7c trong khi sinh, \u0111\u1ed3ng th\u1eddi khuy\u1ebfn kh\u00edch s\u1eed d\u1ee5ng v\u1eafc-xin, c\u00e1c x\u00e9t nghi\u1ec7m v\u00e0 li\u1ec7u ph\u00e1p \u0111\u1ec3 gi\u1ea3m g\u00e1nh n\u1eb7ng b\u1ec7nh t\u1eadt.<\/p>\n

Vi\u1ec7c t\u1eadp trung v\u00e0o l\u00e2y truy\u1ec1n d\u1ecdc t\u1eeb m\u1eb9 sang con \u0111\u1eb7c bi\u1ec7t quan tr\u1ecdng trong vi\u1ec7c gi\u1ea3i quy\u1ebft th\u00e1ch th\u1ee9c c\u1ee7a c\u00e1c b\u1ec7nh nhi\u1ec5m tr\u00f9ng m\u1ea1n t\u00ednh. Ng\u01b0\u1eddi l\u1edbn b\u1ecb nhi\u1ec5m HBV ch\u1ec9 c\u00f3 5% kh\u1ea3 n\u0103ng ph\u00e1t tri\u1ec3n th\u00e0nh b\u1ec7nh m\u1ea1n t\u00ednh. Tuy nhi\u00ean, tr\u1ebb s\u01a1 sinh b\u1ecb nhi\u1ec5m t\u1eeb m\u1eb9 tr\u01b0\u1edbc ho\u1eb7c trong khi sinh c\u00f3 nguy c\u01a1 m\u1eafc b\u1ec7nh m\u1ea1n t\u00ednh l\u00ean t\u1edbi 90%.<\/p>\n

C\u00e1c ca vi\u00eam gan B m\u1ea1n t\u00ednh l\u00e0 nh\u1eefng tr\u01b0\u1eddng h\u1ee3p c\u1ea7n \u0111i\u1ec1u tr\u1ecb li\u00ean t\u1ee5c v\u00e0 theo d\u00f5i th\u01b0\u1eddng xuy\u00ean, khi\u1ebfn ch\u00fang tr\u1edf th\u00e0nh th\u00e1ch th\u1ee9c l\u1edbn nh\u1ea5t.<\/p>\n

Ph\u00e1t tri\u1ec3n d\u1ea5u \u1ea5n sinh h\u1ecdc vi\u00eam gan B (HBV) t\u1ea1i \u00dac<\/h2>\n

T\u1ea1i \u00dac, chi\u1ebfn l\u01b0\u1ee3c qu\u1ed1c gia nh\u1eb1m t\u0103ng c\u01b0\u1eddng ti\u00eam ch\u1ee7ng cho tr\u1ebb em, m\u1edf r\u1ed9ng ch\u1ea9n \u0111o\u00e1n \u0111\u1ec3 n\u1eafm b\u1eaft \u0111\u01b0\u1ee3c nhi\u1ec1u ca b\u1ec7nh m\u1ea1n t\u00ednh h\u01a1n, \u0111\u1ed3ng th\u1eddi t\u0103ng c\u01b0\u1eddng kh\u1ea3 n\u0103ng cung c\u1ea5p thu\u1ed1c kh\u00e1ng vi-r\u00fat v\u00e0 c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00e1c. Gi\u00e1o s\u01b0 Thompson v\u00e0 Gi\u00e1o s\u01b0 Douglas \u0111ang \u0111\u00f3ng g\u00f3p v\u00e0o c\u00f4ng cu\u1ed9c n\u00e0y b\u1eb1ng c\u00e1ch th\u1eed nghi\u1ec7m nhi\u1ec1u lo\u1ea1i kh\u00e1ng nguy\u00ean v\u00e0 d\u1ea5u \u1ea5n sinh h\u1ecdc kh\u00e1c \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh c\u00e1ch th\u1ee9c c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng ch\u00fang \u0111\u1ec3 ch\u1ea9n \u0111o\u00e1n v\u00e0 theo d\u00f5i b\u1ec7nh nh\u00e2n trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb.<\/p>\n

C\u00e1c kh\u00e1ng nguy\u00ean b\u1ec1 m\u1eb7t c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n trong m\u00e1u t\u1eeb th\u1eddi \u0111i\u1ec3m nhi\u1ec5m HBV, v\u00e0 b\u1ec7nh nh\u00e2n m\u1ea1n t\u00ednh \u0111\u1ea1t \u0111\u01b0\u1ee3c tr\u1ea1ng th\u00e1i ch\u1eefa tr\u1ecb ch\u1ee9c n\u0103ng khi nh\u1eefng kh\u00e1ng nguy\u00ean n\u00e0y kh\u00f4ng c\u00f2n \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n n\u1eefa. \u0110o l\u01b0\u1eddng ADN c\u1ee7a HBV l\u00e0 m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111\u00e1nh gi\u00e1 t\u1ea3i l\u01b0\u1ee3ng vi-r\u00fat c\u1ee7a b\u1ec7nh nh\u00e2n v\u00e0 l\u00e0 m\u1ed9t d\u1ea5u \u1ea5n ph\u1ed5 bi\u1ebfn \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb c\u00f3 hi\u1ec7u qu\u1ea3 hay kh\u00f4ng, trong khi HBeAg bi\u1ec3u th\u1ecb ki\u1ec3m so\u00e1t mi\u1ec5n d\u1ecbch. Ho\u1ea1t t\u00ednh d\u1ea5u \u1ea5n sinh h\u1ecdc thay \u0111\u1ed5i th\u00f4ng qua qu\u00e1 tr\u00ecnh nhi\u1ec5m HBV.<\/p>\n

Gi\u00e1o s\u01b0 Douglas cho bi\u1ebft: \u201c\u0110i\u1ec1u th\u1ef1c s\u1ef1 quan tr\u1ecdng l\u00e0 ch\u00fang ta ph\u1ea3i bi\u1ebft c\u00e1ch theo d\u00f5i t\u1ea5t c\u1ea3 c\u00e1c d\u1ea5u \u1ea5n \u0111\u00f3 v\u00e0 bi\u1ebft ch\u00fang ta \u0111ang t\u00ecm ki\u1ebfm g\u00ec \u0111\u1ec3 b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb.\u201d<\/p>\n

\u0110i\u1ec1u quan tr\u1ecdng l\u00e0 ti\u1ebfp t\u1ee5c ph\u00e1t tri\u1ec3n c\u00e1c d\u1ea5u \u1ea5n m\u1edbi. Gi\u00e1o s\u01b0 Thompson cho bi\u1ebft c\u00e1c d\u1ea5u \u1ea5n sinh h\u1ecdc m\u1edbi ph\u00e1t tri\u1ec3n c\u00f3 th\u1ec3 m\u1edf ra k\u1ef7 nguy\u00ean y h\u1ecdc c\u00e1 nh\u00e2n h\u00f3a cho nh\u1eefng ng\u01b0\u1eddi m\u1eafc vi\u00eam gan B. V\u00ed d\u1ee5, \u0111\u1ecbnh l\u01b0\u1ee3ng c\u00e1c d\u1ea5u \u1ea5n kh\u00e1ng nguy\u00ean b\u1ec1 m\u1eb7t b\u1eb1ng ELISA thay v\u00ec ch\u1ec9 b\u00e1o c\u00e1o k\u1ebft qu\u1ea3 \u00e2m t\u00ednh ho\u1eb7c d\u01b0\u01a1ng t\u00ednh c\u00f3 th\u1ec3 mang l\u1ea1i gi\u00e1 tr\u1ecb gia t\u0103ng cho c\u00e1c d\u1ea5u \u1ea5n n\u00e0y trong vi\u1ec7c x\u00e1c \u0111\u1ecbnh th\u1eddi \u0111i\u1ec3m b\u1eaft \u0111\u1ea7u ho\u1eb7c d\u1eebng \u0111i\u1ec1u tr\u1ecb cho m\u1ed7i b\u1ec7nh nh\u00e2n.<\/p>\n

C\u00e1c d\u1ea5u \u1ea5n sinh h\u1ecdc m\u1edbi c\u0169ng c\u00f3 th\u1ec3 d\u1ef1 \u0111o\u00e1n li\u1ec7u b\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c giai \u0111o\u1ea1n ch\u1eefa tr\u1ecb ch\u1ee9c n\u0103ng hay kh\u00f4ng, v\u00e0 li\u1ec7u m\u1ed9t b\u1ec7nh nh\u00e2n mang thai c\u00f3 kh\u1ea3 n\u0103ng truy\u1ec1n vi-r\u00fat cho con c\u1ee7a c\u00f4 \u1ea5y hay kh\u00f4ng. Trong c\u00e1c nghi\u00ean c\u1ee9u m\u1edbi v\u1ec1 \u0111i\u1ec1u tr\u1ecb b\u1eb1ng interferon, m\u1ee9c \u0111\u1ed9 kh\u00e1ng nguy\u00ean b\u1ec1 m\u1eb7t c\u00f3 th\u1ec3 d\u1ef1 \u0111o\u00e1n b\u1ec7nh nh\u00e2n n\u00e0o s\u1ebd \u0111\u01b0\u1ee3c h\u01b0\u1edfng l\u1ee3i t\u1eeb vi\u1ec7c ti\u1ebfp t\u1ee5c \u0111i\u1ec1u tr\u1ecb v\u00e0 b\u1ec7nh nh\u00e2n n\u00e0o s\u1ebd kh\u00f4ng.<\/p>\n

Gi\u00e1o s\u01b0 Thompson cho bi\u1ebft: \u201cCh\u00fang t\u00f4i ngh\u0129 r\u1eb1ng m\u1ee9c \u0111\u1ed9 kh\u00e1ng nguy\u00ean b\u1ec1 m\u1eb7t hi\u1ec7n \u0111\u00e3 s\u1eb5n s\u00e0ng cho giai \u0111o\u1ea1n quan tr\u1ecdng\u201d, \u0111\u1ed3ng th\u1eddi khuy\u1ebfn ngh\u1ecb x\u00e9t nghi\u1ec7m d\u1ea5u \u1ea5n sinh h\u1ecdc n\u00e0y cho t\u1ea5t c\u1ea3 b\u1ec7nh nh\u00e2n m\u1eafc vi\u00eam gan B. Ph\u01b0\u01a1ng ph\u00e1p n\u00e0y c\u0169ng c\u00f3 th\u1ec3 quan tr\u1ecdng trong t\u01b0\u01a1ng lai \u0111\u1ec3 l\u1ef1a ch\u1ecdn ph\u00f9 h\u1ee3p c\u00e1c li\u1ec7u ph\u00e1p m\u1edbi \u0111ang \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n, ch\u1eb3ng h\u1ea1n nh\u01b0 oligonucleotide ch\u1ed1ng c\u1ea3m \u1ee9ng ti\u00eam truy\u1ec1n, hi\u1ec7n \u0111ang trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng. \u00d4ng cho bi\u1ebft th\u00eam: \u201cM\u1ed9t k\u1ef7 nguy\u00ean m\u1edbi c\u1ee7a li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb vi\u00eam gan B \u0111ang \u0111\u1ebfn.\u201d<\/p>\n

M\u1ed9t d\u1ea5u \u1ea5n sinh h\u1ecdc m\u1edbi ph\u00e1t tri\u1ec3n \u0111\u1ea7y h\u1ee9a h\u1eb9n l\u00e0 ARN c\u1ee7a HBV, c\u00f3 th\u1ec3 cung c\u1ea5p m\u1ed9t c\u00e1i nh\u00ecn h\u1eefu \u00edch h\u01a1n v\u1ec1 ho\u1ea1t \u0111\u1ed9ng phi\u00ean m\u00e3 so v\u1edbi ADN c\u1ee7a HBV. Trong m\u1ed9t nghi\u00ean c\u1ee9u d\u1eebng \u0111i\u1ec1u tr\u1ecb b\u1eb1ng thu\u1ed1c kh\u00e1ng vi\u00eam gan B, v\u00ed d\u1ee5, ARN c\u1ee7a HBV gia t\u0103ng \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 l\u00e0m t\u0103ng nguy c\u01a1 vi\u00eam gan t\u00e1i ph\u00e1t v\u00e0 c\u00f3 m\u1ed1i li\u00ean h\u1ec7 ti\u00eau c\u1ef1c v\u1edbi vi\u1ec7c m\u1ea5t HBsAg. Gi\u00e1o s\u01b0 Thompson c\u0169ng l\u01b0u \u00fd r\u1eb1ng ARN c\u1ee7a HBV c\u00f3 th\u1ec3 c\u00f3 gi\u00e1 tr\u1ecb l\u00e2m s\u00e0ng trong vi\u1ec7c d\u1ef1 \u0111o\u00e1n t\u00e1i ho\u1ea1t vi\u00eam gan B \u1edf b\u1ec7nh nh\u00e2n suy gi\u1ea3m mi\u1ec5n d\u1ecbch, nguy c\u01a1 ung th\u01b0 gan (HCC) ho\u1eb7c ph\u1ea3n \u1ee9ng v\u1edbi c\u00e1c li\u1ec7u ph\u00e1p m\u1edbi.<\/p>\n

\u00d4ng n\u00f3i: \u201cARN c\u1ee7a HBV trong huy\u1ebft thanh c\u00f3 v\u1ebb h\u1ee9a h\u1eb9n v\u00e0 c\u1ea7n ph\u1ea3i nghi\u00ean c\u1ee9u th\u00eam.\u201d \u201cT\u00f4i mong ch\u1edd k\u1ebft qu\u1ea3 v\u00e0 d\u1eef li\u1ec7u s\u1ebd \u0111\u1ea1t \u0111\u01b0\u1ee3c trong v\u00e0i n\u0103m t\u1edbi.\u201d<\/p>\n

\u0110\u1ec3 t\u00ecm hi\u1ec3u th\u00eam v\u1ec1 x\u00e9t nghi\u1ec7m HBV, h\u00e3y xem h\u1ed9i th\u1ea3o tr\u00ean web \u0111\u1ea7y \u0111\u1ee7 <\/a>v\u1edbi Gi\u00e1o s\u01b0 Thompson v\u00e0 Ph\u00f3 Gi\u00e1o s\u01b0 Douglas ho\u1eb7c xem c\u00e1c b\u00e0i vi\u1ebft kh\u00e1c n\u00e0y<\/a> t\u1eeb Lab Insights.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

Trong b\u1ed1i c\u1ea3nh c\u00e1c n\u1ed7 l\u1ef1c y t\u1ebf to\u00e0n c\u1ea7u ng\u00e0y c\u00e0ng t\u0103ng nh\u1eb1m gi\u1ea3m t\u1ef7 l\u1ec7 t\u1eed vong do vi\u00eam gan B (HBV), c\u00e1c nh\u00e0 l\u00e3nh \u0111\u1ea1o trong l\u0129nh v\u1ef1c ph\u00f2ng x\u00e9t nghi\u1ec7m v\u00e0 ch\u0103m s\u00f3c s\u1ee9c kh\u1ecfe tr\u00ean kh\u1eafp th\u1ebf gi\u1edbi \u0111ang ph\u00e1t tri\u1ec3n v\u00e0 tri\u1ec3n khai c\u00e1c d\u1ea5u \u1ea5n sinh h\u1ecdc m\u1edbi […]<\/p>\n","protected":false},"author":1,"featured_media":85767,"parent":0,"menu_order":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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