{"id":147181,"date":"2023-01-16T02:19:53","date_gmt":"2023-01-16T02:19:53","guid":{"rendered":"https:\/\/labinsights.com\/acf_article\/dau-an-sinh-hoc-trong-huyet-khoi-lien-quan-den-ung-thu-goc-nhin-tu-giao-su-anna-falanga-va-cinzia-giaccherini\/"},"modified":"2026-02-23T10:10:58","modified_gmt":"2026-02-23T10:10:58","slug":"biomarkers-in-cancer-associated-thrombosis-insights-from-prof-anna-falanga-and-cinzia-giaccherini","status":"publish","type":"acf_article","link":"https:\/\/labinsights.com\/vi\/disease-area\/oncology\/biomarkers-in-cancer-associated-thrombosis-insights-from-prof-anna-falanga-and-cinzia-giaccherini\/","title":{"rendered":"D\u1ea5u \u1ea5n sinh h\u1ecdc trong huy\u1ebft kh\u1ed1i li\u00ean quan \u0111\u1ebfn ung th\u01b0: g\u00f3c nh\u00ecn t\u1eeb Gi\u00e1o s\u01b0 Anna Falanga v\u00e0 Cinzia Giaccherini"},"content":{"rendered":"

Trong m\u1ed9t h\u1ed9i th\u1ea3o tr\u00ean web<\/a> \u0111\u01b0\u1ee3c t\u1ed5 ch\u1ee9c v\u00e0o World Thrombosis Day 2022, hai chuy\u00ean gia v\u1ec1 \u0111\u00f4ng m\u00e1u \u2014 Gi\u00e1o s\u01b0 Anna Falanga, Gi\u00e1o s\u01b0 Huy\u1ebft h\u1ecdc t\u1ea1i \u0110\u1ea1i h\u1ecdc Milan Biocca v\u00e0 Cinzia Giaccherini, m\u1ed9t nh\u00e0 sinh h\u1ecdc nghi\u00ean c\u1ee9u v\u1edbi h\u01a1n 10 n\u0103m kinh nghi\u1ec7m v\u1ec1 c\u1ea7m m\u00e1u v\u00e0 huy\u1ebft kh\u1ed1i \u2014 \u0111\u00e3 th\u1ea3o lu\u1eadn v\u1ec1 vai tr\u00f2 d\u1ef1 \u0111o\u00e1n c\u1ee7a c\u00e1c d\u1ea5u \u1ea5n sinh h\u1ecdc trong huy\u1ebft kh\u1ed1i li\u00ean quan \u0111\u1ebfn ung th\u01b0 (CAT).<\/p>\n

Gi\u00e1o s\u01b0 Anna Falanga b\u1eaft \u0111\u1ea7u b\u1eb1ng vi\u1ec7c tr\u00ecnh b\u00e0y t\u1ed5ng quan v\u1ec1 d\u1ef1 \u0111o\u00e1n v\u00e0 ph\u00f2ng ng\u1eeba nguy c\u01a1 CAT. C\u00e1c nghi\u00ean c\u1ee9u \u0111o\u00e0n h\u1ec7 \u1edf V\u01b0\u01a1ng qu\u1ed1c Anh v\u00e0 \u0110an M\u1ea1ch \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng b\u1ec7nh nh\u00e2n ung th\u01b0 c\u00f3 nguy c\u01a1 m\u1eafc huy\u1ebft kh\u1ed1i t\u0129nh m\u1ea1ch (VTE) cao g\u1ea5p 4\u201311 l\u1ea7n so v\u1edbi b\u1ec7nh nh\u00e2n kh\u00f4ng m\u1eafc ung th\u01b0, t\u00f9y thu\u1ed9c v\u00e0o lo\u1ea1i ung th\u01b0; v\u1edbi VTE \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn t\u1ef7 l\u1ec7 b\u1ec7nh t\u1eadt v\u00e0 t\u1eed vong \u1edf b\u1ec7nh nh\u00e2n ung th\u01b0.<\/p>\n

\u0110\u1ec3 ng\u0103n ng\u1eeba VTE, c\u1ea7n x\u00e1c \u0111\u1ecbnh nh\u1eefng b\u1ec7nh nh\u00e2n ung th\u01b0 c\u00f3 nguy c\u01a1 cao, nh\u1eefng ng\u01b0\u1eddi c\u00f3 th\u1ec3 h\u01b0\u1edfng l\u1ee3i t\u1eeb vi\u1ec7c ph\u00f2ng ng\u1eeba huy\u1ebft kh\u1ed1i ban \u0111\u1ea7u. C\u00e1c m\u00f4-\u0111un \u0111\u00e1nh gi\u00e1 nguy c\u01a1 (RAM) nh\u01b0 \u0111i\u1ec3m Khorana c\u00f3 th\u1ec3 d\u1ef1 \u0111o\u00e1n nguy c\u01a1 VTE \u1edf b\u1ec7nh nh\u00e2n. C\u00e1c RAM c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c b\u1ed5 sung b\u1eb1ng c\u00e1c d\u1ea5u \u1ea5n sinh h\u1ecdc \u0111\u1ec3 c\u1ea3i thi\u1ec7n kh\u1ea3 n\u0103ng d\u1ef1 \u0111o\u00e1n.<\/p>\n

Cinzia Giaccherini sau \u0111\u00f3 \u0111\u00e3 th\u1ea3o lu\u1eadn v\u1ec1 c\u00e1c d\u1ea5u \u1ea5n sinh h\u1ecdc d\u00f9ng \u0111\u1ec3 d\u1ef1 \u0111o\u00e1n CAT v\u00e0 d\u1ef1 b\u00e1o ti\u1ebfn tri\u1ec3n b\u1ec7nh \u1edf b\u1ec7nh nh\u00e2n ung th\u01b0 ph\u1ed5i. C\u00e1c d\u1ea5u \u1ea5n sinh h\u1ecdc \u0111\u00f4ng m\u00e1u nh\u01b0 D-dimer \u0111\u01b0\u1ee3c cho l\u00e0 c\u00f3 th\u1ec3 h\u1eefu \u00edch trong vi\u1ec7c \u0111\u00e1nh gi\u00e1 nguy c\u01a1 huy\u1ebft kh\u1ed1i c\u00e1 nh\u00e2n c\u1ee7a b\u1ec7nh nh\u00e2n. C\u00f3 b\u1eb1ng ch\u1ee9ng x\u00e1c th\u1ef1c vi\u1ec7c s\u1eed d\u1ee5ng c\u00e1c d\u1ea5u \u1ea5n sinh h\u1ecdc n\u00e0y \u1edf b\u1ec7nh nh\u00e2n ung th\u01b0 ph\u1ed5i, trong \u0111\u00f3 ch\u00fang c\u0169ng c\u00f3 th\u1ec3 l\u00e0 ch\u1ec9 th\u1ecb c\u1ee7a ti\u00ean l\u01b0\u1ee3ng x\u1ea5u.<\/p>\n

Nhi\u1ec1u nghi\u00ean c\u1ee9u \u0111\u00e3 b\u00e1o c\u00e1o m\u1ed1i li\u00ean quan \u0111\u00e1ng k\u1ec3 gi\u1eefa m\u1ee9c D-dimer huy\u1ebft t\u01b0\u01a1ng t\u0103ng cao v\u1edbi kh\u1ed1i u l\u1edbn, s\u1ef1 ti\u1ebfn tri\u1ec3n b\u1ec7nh v\u00e0 t\u1ef7 l\u1ec7 t\u1eed vong. C\u1ea7n c\u00f3 th\u00eam c\u00e1c nghi\u00ean c\u1ee9u \u0111\u1ec3 c\u1ee7ng c\u1ed1 b\u1eb1ng ch\u1ee9ng hi\u1ec7n t\u1ea1i v\u00e0 khuy\u1ebfn kh\u00edch vi\u1ec7c s\u1eed d\u1ee5ng c\u00e1c m\u00f4 h\u00ecnh d\u1ef1a tr\u00ean d\u1ea5u \u1ea5n sinh h\u1ecdc \u0111\u00f4ng m\u00e1u trong th\u1ef1c h\u00e0nh l\u00e2m s\u00e0ng trong t\u01b0\u01a1ng lai.<\/p>\n

Trong ph\u1ea7n H\u1ecfi \u0110\u00e1p, thuy\u00ean t\u1eafc ph\u1ed5i \u0111\u00e3 \u0111\u01b0\u1ee3c nh\u1eafc \u0111\u1ebfn l\u00e0 ph\u1ed5 bi\u1ebfn nh\u1ea5t \u1edf b\u1ec7nh nh\u00e2n ung th\u01b0 ph\u1ed5i, v\u1edbi ch\u1ea9n \u0111o\u00e1n th\u01b0\u1eddng \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n trong qu\u00e1 tr\u00ecnh s\u00e0ng l\u1ecdc ung th\u01b0. V\u1ec1 vi\u1ec7c \u0111i\u1ec1u tr\u1ecb VTE b\u1eb1ng edoxaban, khuy\u1ebfn c\u00e1o ti\u1ebfp t\u1ee5c \u0111i\u1ec1u tr\u1ecb trong 12 th\u00e1ng v\u1edbi c\u00f9ng li\u1ec1u, sau \u0111\u00f3 m\u1edbi \u0111i\u1ec1u ch\u1ec9nh n\u1ebfu v\u1eabn c\u00f2n VTE.<\/p>\n

D-dimer \u0111\u01b0\u1ee3c ghi nh\u1eadn l\u00e0 m\u1ed9t d\u1ea5u \u1ea5n ti\u1ec1m n\u0103ng cho VTE v\u00e0 l\u00e0 ch\u1ec9 th\u1ecb d\u1ef1 b\u00e1o ti\u1ebfn tri\u1ec3n b\u1ec7nh. C\u00f3 gi\u1ea3 thuy\u1ebft r\u1eb1ng nh\u00f3m \u0111\u1ed1i t\u01b0\u1ee3ng l\u1edbn tu\u1ed5i v\u00e0 c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ung th\u01b0 m\u1edbi c\u00f3 th\u1ec3 c\u00f3 nguy c\u01a1 huy\u1ebft kh\u1ed1i ng\u00e0y c\u00e0ng t\u0103ng \u1edf t\u1ea5t c\u1ea3 c\u00e1c lo\u1ea1i ung th\u01b0.<\/p>\n

Gi\u00e1o s\u01b0 Anna Falanga, MD, l\u00e0 Gi\u00e1o s\u01b0 chuy\u00ean khoa Huy\u1ebft h\u1ecdc t\u1ea1i \u0110\u1ea1i h\u1ecdc Milan Biocca v\u00e0 Tr\u01b0\u1edfng khoa Huy\u1ebft h\u1ecdc mi\u1ec5n d\u1ecbch v\u00e0 Y h\u1ecdc truy\u1ec1n m\u00e1u v\u00e0 Trung t\u00e2m huy\u1ebft kh\u1ed1i v\u00e0 c\u1ea7m m\u00e1u t\u1ea1i B\u1ec7nh vi\u1ec7n Papa Giovanni XXIII, \u1edf Bergamo, \u00dd. B\u00e0 l\u00e0 t\u00e1c gi\u1ea3 c\u1ee7a h\u01a1n 300 \u1ea5n ph\u1ea9m v\u00e0 l\u00e0 bi\u00ean t\u1eadp vi\u00ean kh\u00e1ch m\u1eddi c\u1ee7a 21 t\u1eadp, b\u00e0 c\u0169ng l\u00e0 m\u1ed9t chuy\u00ean gia trong l\u0129nh v\u1ef1c ung th\u01b0 v\u00e0 huy\u1ebft kh\u1ed1i.<\/em><\/p>\n

Cinzia Giaccherini l\u00e0 m\u1ed9t nh\u00e0 sinh h\u1ecdc nghi\u00ean c\u1ee9u v\u1edbi h\u01a1n 10 n\u0103m kinh nghi\u1ec7m t\u1ea1i Ph\u00f2ng x\u00e9t nghi\u1ec7m C\u1ea7m m\u00e1u v\u00e0 Huy\u1ebft kh\u1ed1i thu\u1ed9c Khoa Mi\u1ec5n d\u1ecbch Huy\u1ebft h\u1ecdc v\u00e0 Y h\u1ecdc Truy\u1ec1n m\u00e1u t\u1ea1i B\u1ec7nh vi\u1ec7n Papa Giovanni XXIII \u1edf Bergamo (\u00dd). B\u00e0 c\u0169ng \u0111ang theo h\u1ecdc ch\u01b0\u01a1ng tr\u00ecnh chuy\u00ean s\u00e2u sau \u0111\u1ea1i h\u1ecdc v\u1ec1 Th\u1ed1ng k\u00ea Y h\u1ecdc v\u00e0 Sinh h\u1ecdc Th\u1ed1ng k\u00ea t\u1ea1i \u0110\u1ea1i h\u1ecdc Milan.<\/em><\/p>\n

Ngu\u1ed3n th\u00f4ng tin b\u1ed5 sung:<\/strong><\/em><\/p>\n

[1]<\/a> Falanga, A. et al. (2022) \u201cHow well do European patients understand cancer-associated thrombosis? A patient survey,\u201d Cancer Treatment and Research Communications, 31, p. 100557. Truy c\u1eadp: https:\/\/doi.org\/10.1016\/j.ctarc.2022.100557.<\/p>\n

[2] <\/a>Falanga, A. et al. (2021) \u201cManagement of cancer-associated thrombosis: Unmet needs and future perspectives,\u201d TH Open, 05(03). Truy c\u1eadp: https:\/\/doi.org\/10.1055\/s-0041-1736037.<\/p>\n

[3]<\/a> Falanga, A. et al. (2022) \u201cThrombotic complications in patients with cancer: Advances in pathogenesis, prevention, and treatment\u2014a report from ICTHIC 2021,\u201d Research and Practice in Thrombosis and Haemostasis, 6(5). Truy c\u1eadp: https:\/\/doi.org\/10.1002\/rth2.12744.<\/p>\n

[4]<\/a> Pesenti, M. et al. (2020) \u201cThrombin generation and D-dimer significantly predict for early disease progression and mortality in patients with gastrointestinal cancer,\u201d Blood, 136(Supplement 1), pp. 32\u201332. Truy c\u1eadp: https:\/\/doi.org\/10.1182\/blood-2020-136631.<\/p>\n

[5]<\/a> Falanga, A. et al. (2019) \u201cThrombotic risk assessment in a prospective cohort of newly diagnosed ambulatory cancer patients candidate to Chemotherapy,\u201d Blood, 134(Supplement_1), pp. 3642\u20133642. Truy c\u1eadp: https:\/\/doi.org\/10.1182\/blood-2019-129901.<\/p>\n","protected":false},"excerpt":{"rendered":"

Trong m\u1ed9t h\u1ed9i th\u1ea3o tr\u00ean web \u0111\u01b0\u1ee3c t\u1ed5 ch\u1ee9c v\u00e0o World Thrombosis Day 2022, hai chuy\u00ean gia v\u1ec1 \u0111\u00f4ng m\u00e1u \u2014 Gi\u00e1o s\u01b0 Anna Falanga, Gi\u00e1o s\u01b0 Huy\u1ebft h\u1ecdc t\u1ea1i \u0110\u1ea1i h\u1ecdc Milan Biocca v\u00e0 Cinzia Giaccherini, m\u1ed9t nh\u00e0 sinh h\u1ecdc nghi\u00ean c\u1ee9u v\u1edbi h\u01a1n 10 n\u0103m kinh nghi\u1ec7m v\u1ec1 c\u1ea7m m\u00e1u v\u00e0 huy\u1ebft kh\u1ed1i […]<\/p>\n","protected":false},"author":1,"featured_media":85656,"parent":0,"menu_order":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"no-sidebar","site-content-layout":"","ast-site-content-layout":"full-width-container","site-content-style":"unboxed","site-sidebar-style":"unboxed","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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