{"id":147193,"date":"2022-09-02T01:33:59","date_gmt":"2022-09-02T01:33:59","guid":{"rendered":"https:\/\/labinsights.com\/acf_article\/cac-lieu-phap-dieu-tri-benh-mau-kho-dong-dang-xuat-hien-lam-noi-bat-nhu-cau-can-chan-doan-chat-luong\/"},"modified":"2026-02-23T12:03:50","modified_gmt":"2026-02-23T12:03:50","slug":"emerging-haemophilia-therapies-highlight-a-need-for-quality-diagnostics","status":"publish","type":"acf_article","link":"https:\/\/labinsights.com\/vi\/disease-area\/rare-diseases\/emerging-haemophilia-therapies-highlight-a-need-for-quality-diagnostics\/","title":{"rendered":"C\u00e1c li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb b\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng \u0111ang xu\u1ea5t hi\u1ec7n l\u00e0m n\u1ed5i b\u1eadt nhu c\u1ea7u c\u1ea7n ch\u1ea9n \u0111o\u00e1n ch\u1ea5t l\u01b0\u1ee3ng"},"content":{"rendered":"

B\u00e0i vi\u1ebft n\u00e0y l\u00e0 ph\u1ea7n 2 trong lo\u1ea1t b\u00e0i v\u1ec1 ch\u1ea9n \u0111o\u00e1n v\u00e0 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng. B\u00e0i vi\u1ebft \u0111\u1ea7u ti\u00ean, c\u00f3 th\u1ec3 xem t\u1ea1i \u0111\u00e2y<\/a>, cung c\u1ea5p c\u00e1i nh\u00ecn t\u1ed5ng quan v\u1ec1 bi\u1ec3u hi\u1ec7n l\u00e2m s\u00e0ng, ch\u1ea9n \u0111o\u00e1n v\u00e0 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh n\u00e0y.<\/p>\n

Khi c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u ph\u00e1t tri\u1ec3n c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi s\u00e1ng t\u1ea1o cho b\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng, c\u00e1c chuy\u00ean gia ph\u00f2ng x\u00e9t nghi\u1ec7m l\u00e2m s\u00e0ng n\u00ean nh\u1eadn th\u1ee9c \u0111\u01b0\u1ee3c v\u1ec1 nh\u1eefng ti\u1ebfn tri\u1ec3n n\u00e0y v\u00e0 t\u00e1c \u0111\u1ed9ng ti\u1ec1m \u1ea9n c\u1ee7a ch\u00fang \u0111\u1ed1i v\u1edbi quy tr\u00ecnh ch\u1ea9n \u0111o\u00e1n. B\u00e0i vi\u1ebft n\u00e0y s\u1ebd kh\u00e1m ph\u00e1 m\u1ed9t s\u1ed1 ph\u01b0\u01a1ng th\u1ee9c \u0111i\u1ec1u tr\u1ecb \u0111ang xu\u1ea5t hi\u1ec7n v\u00e0 \u00fd ngh\u0129a c\u1ee7a ch\u00fang \u0111\u1ed1i v\u1edbi y h\u1ecdc x\u00e9t nghi\u1ec7m.<\/p>\n

M\u1ed9t s\u1ed1 li\u1ec7u ph\u00e1p \u0111ang xu\u1ea5t hi\u1ec7n \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng l\u00e0 g\u00ec?<\/h2>\n

Ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb b\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng hi\u1ec7n nay t\u1eadp trung v\u00e0o li\u1ec7u ph\u00e1p thay th\u1ebf, m\u1ed9t qu\u00e1 tr\u00ecnh s\u1eed d\u1ee5ng c\u00e1c ch\u1ea5t c\u00f4 \u0111\u1eb7c y\u1ebfu t\u1ed1 \u0111\u00f4ng m\u00e1u \u0111\u1ec3 b\u1ed5 sung v\u00e0o m\u00e1u c\u1ee7a b\u1ec7nh nh\u00e2n. Nh\u1eefng ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb n\u00e0y c\u00f3 th\u1ec3 g\u00e2y ra c\u00e1c bi\u1ebfn ch\u1ee9ng, ch\u1eb3ng h\u1ea1n nh\u01b0 s\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a c\u00e1c kh\u00e1ng th\u1ec3 trung h\u00f2a (ch\u1ea5t \u1ee9c ch\u1ebf) t\u1ea5n c\u00f4ng y\u1ebfu t\u1ed1 \u0111\u00f4ng m\u00e1u trong m\u00e1u v\u00e0 d\u1eabn \u0111\u1ebfn t\u1ef7 l\u1ec7 m\u1eafc b\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng cao h\u01a1n [1].<\/p>\n

\u0110\u1ec3 gi\u1ea3i quy\u1ebft nh\u1eefng v\u1ea5n \u0111\u1ec1 n\u00e0y v\u00e0 nhi\u1ec1u v\u1ea5n \u0111\u1ec1 kh\u00e1c, c\u00e1c chuy\u00ean gia ch\u0103m s\u00f3c s\u1ee9c kh\u1ecfe \u0111ang kh\u00e1m ph\u00e1 nhi\u1ec1u ph\u01b0\u01a1ng ph\u00e1p ti\u1ebfp c\u1eadn m\u1edbi \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng, bao g\u1ed3m c\u00e1c y\u1ebfu t\u1ed1 \u0111\u00f4ng m\u00e1u th\u1eddi gian b\u00e1n th\u1ea3i k\u00e9o d\u00e0i (EHL); kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng nh\u1eafm v\u00e0o ch\u1ea5t \u1ee9c ch\u1ebf \u0111\u01b0\u1eddng y\u1ebfu t\u1ed1 m\u00f4 (TFPI); kh\u00e1ng th\u1ec3 \u0111\u1eb7c hi\u1ec7u k\u00e9p ho\u1ea1t \u0111\u1ed9ng nh\u01b0 li\u1ec7u ph\u00e1p kh\u00f4ng thay th\u1ebf y\u1ebfu t\u1ed1; v\u00e0 li\u1ec7u ph\u00e1p gen h\u1ee9a h\u1eb9n ch\u1eefa kh\u1ecfi t\u00ecnh tr\u1ea1ng n\u00e0y.<\/p>\n

C\u00e1c y\u1ebfu t\u1ed1 \u0111\u00f4ng m\u00e1u EHL<\/strong><\/p>\n

K\u1ec3 t\u1eeb nh\u1eefng n\u0103m 2010, c\u00f4ng ngh\u1ec7 t\u00e1i t\u1ed5 h\u1ee3p \u0111\u00e3 \u0111\u01b0\u1ee3c gi\u1edbi thi\u1ec7u \u0111\u1ec3 ch\u1ec9nh s\u1eeda c\u00e1c y\u1ebfu t\u1ed1 nh\u1eb1m k\u00e9o d\u00e0i th\u1eddi gian l\u01b0u th\u00f4ng c\u1ee7a ch\u00fang, gi\u1ea3m t\u1ea7n su\u1ea5t d\u00f9ng thu\u1ed1c [2]. Hi\u1ec7n t\u1ea1i,\u00a0c\u00e1c s\u1ea3n ph\u1ea9m EHL FVIII v\u00e0 FXI \u0111\u00e3 c\u00f3 s\u1eb5n. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a nhi\u1ec1u s\u1ea3n ph\u1ea9m EHL \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh r\u00f5 r\u00e0ng, \u0111\u1eb7c bi\u1ec7t l\u00e0 trong vi\u1ec7c ph\u00f2ng ng\u1eeba v\u00e0 \u0111i\u1ec1u tr\u1ecb xu\u1ea5t huy\u1ebft.<\/p>\n

Kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng nh\u1eafm v\u00e0o ch\u1ea5t \u1ee9c ch\u1ebf \u0111\u01b0\u1eddng y\u1ebfu t\u1ed1 m\u00f4 (TFPI)<\/strong><\/p>\n

Nhi\u1ec1u nghi\u00ean c\u1ee9u \u0111ang \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh v\u1ec1 kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng nh\u1eafm v\u00e0o ch\u1ea5t \u1ee9c ch\u1ebf TFPI v\u00e0 h\u1ee9a h\u1eb9n t\u0103ng c\u01b0\u1eddng ho\u1ea1t \u0111\u1ed9ng c\u1ea7m m\u00e1u, h\u00ecnh th\u00e0nh c\u1ee5c m\u00e1u \u0111\u00f4ng \u1ed5n \u0111\u1ecbnh h\u01a1n v\u00e0 gi\u1ea3m c\u00e1c bi\u1ebfn c\u1ed1 xu\u1ea5t huy\u1ebft sau \u0111\u00f3. M\u1ed9t v\u00ed d\u1ee5 l\u00e0 concizumab, m\u1ed9t kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng c\u1ee7a con ng\u01b0\u1eddi \u0111ang \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng giai \u0111o\u1ea1n 2 \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n m\u1eafc b\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng A v\u00e0 B. \u00a0D\u1ef1 ki\u1ebfn concizumab s\u1ebd \u0111\u01b0\u1ee3c ph\u00ea duy\u1ec7t theo quy \u0111\u1ecbnh \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng A ho\u1eb7c B t\u1ea1i Li\u00ean minh Ch\u00e2u \u00c2u, V\u01b0\u01a1ng qu\u1ed1c Anh v\u00e0 Hoa K\u1ef3 v\u00e0o n\u0103m 2023\/2024. \u00a0 Vi\u1ec7c thu tuy\u1ec3n c\u0169ng \u0111ang \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh cho th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng giai \u0111o\u1ea1n 1 c\u1ee7a BAY1093884, m\u1ed9t kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng kh\u00e1c t\u01b0\u01a1ng t\u1ef1 nh\u01b0 concizumab.<\/p>\n

Kh\u00e1ng th\u1ec3 \u0111\u1eb7c hi\u1ec7u k\u00e9p c\u00f3 t\u00e1c d\u1ee5ng nh\u01b0 li\u1ec7u ph\u00e1p kh\u00f4ng thay th\u1ebf y\u1ebfu t\u1ed1<\/strong><\/p>\n

C\u00e1c li\u1ec7u ph\u00e1p \u0111ang xu\u1ea5t hi\u1ec7n kh\u00e1c bao g\u1ed3m c\u00e1c s\u1ea3n ph\u1ea9m kh\u00f4ng thay th\u1ebf y\u1ebfu t\u1ed1. \u0110\u00e2y th\u01b0\u1eddng l\u00e0 nh\u1eefng kh\u00e1ng th\u1ec3 \u0111\u1eb7c hi\u1ec7u k\u00e9p nh\u01b0 emicizumab c\u00f3 t\u00e1c d\u1ee5ng m\u00f4 ph\u1ecfng c\u00e1c y\u1ebfu t\u1ed1 \u0111\u00f4ng m\u00e1u, gi\u00fap k\u1ebft n\u1ed1i FXIa v\u00e0 FX m\u1ed9t c\u00e1ch hi\u1ec7u qu\u1ea3. \u00a0Emicizumab \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh d\u00f9ng cho d\u1ef1 ph\u00f2ng th\u01b0\u1eddng quy \u1edf b\u1ec7nh nh\u00e2n ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb em c\u00f3 ch\u1ea5t \u1ee9c ch\u1ebf FVIII. Thu\u1ed1c n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1ea5p ch\u1ec9 \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb \u0111\u1ed9t ph\u00e1 (breakthrough therapy designation) cho b\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng A v\u00e0o th\u00e1ng 4 n\u0103m 2018[3].<\/p>\n

Li\u1ec7u ph\u00e1p gen h\u1ee9a h\u1eb9n c\u00f3 th\u1ec3 ch\u1eefa kh\u1ecfi t\u00ecnh tr\u1ea1ng n\u00e0y<\/strong><\/p>\n

Ngo\u00e0i ra, li\u1ec7u ph\u00e1p gen \u0111ang \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u nh\u01b0 m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p ti\u1ec1m n\u0103ng ch\u1eefa kh\u1ecfi b\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng. V\u00e0o ng\u00e0y 24 th\u00e1ng 5 n\u0103m 2022, FDA \u0111\u00e3 ch\u1ea5p nh\u1eadn y\u00eau c\u1ea7u duy\u1ec7t x\u00e9t \u01b0u ti\u00ean \u0111\u1ed1i v\u1edbi etranacogene dezaparvovec cho m\u1ed9t li\u1ec7u ph\u00e1p gen \u0111i\u1ec1u tr\u1ecb b\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng B [4]. V\u00e0o ng\u00e0y 24 th\u00e1ng 6 n\u0103m 2022, C\u01a1 quan D\u01b0\u1ee3c ph\u1ea9m Ch\u00e2u \u00c2u \u0111\u00e3 khuy\u1ebfn ngh\u1ecb c\u1ea5p ph\u00e9p c\u00f3 \u0111i\u1ec1u ki\u1ec7n cho valoctocogene roxaparvovec \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb cho nh\u1eefng b\u1ec7nh nh\u00e2n m\u1eafc b\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng A n\u1eb7ng kh\u00f4ng c\u00f3 ch\u1ea5t \u1ee9c ch\u1ebf y\u1ebfu t\u1ed1 VIII. Hi\u1ec7n t\u1ea1i, thu\u1ed1c n\u00e0y \u0111ang ch\u1edd quy\u1ebft \u0111\u1ecbnh ph\u00ea duy\u1ec7t c\u1ee7a \u1ee6y ban Ch\u00e2u \u00c2u [5].<\/p>\n

\u0110i\u1ec1u n\u00e0y c\u00f3 \u00fd ngh\u0129a g\u00ec \u0111\u1ed1i v\u1edbi ch\u1ea9n \u0111o\u00e1n trong ph\u00f2ng x\u00e9t nghi\u1ec7m?<\/h2>\n

Ch\u1ea9n \u0111o\u00e1n trong ph\u00f2ng x\u00e9t nghi\u1ec7m l\u00e2m s\u00e0ng \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c theo d\u00f5i hi\u1ec7u qu\u1ea3 c\u1ee7a c\u00e1c li\u1ec7u ph\u00e1p kh\u00e1c nhau \u0111i\u1ec1u tr\u1ecb b\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng. V\u00ed d\u1ee5: khi \u00e1p d\u1ee5ng li\u1ec7u ph\u00e1p thay th\u1ebf, vi\u1ec7c l\u1ef1a ch\u1ecdn ch\u1ea5t c\u00f4 \u0111\u1eb7c y\u1ebfu t\u1ed1 l\u00e0 r\u1ea5t quan tr\u1ecdng v\u00ec \u0111i\u1ec1u \u0111\u00f3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn vi\u1ec7c l\u1ef1a ch\u1ecdn x\u00e9t nghi\u1ec7m \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111o l\u01b0\u1eddng.<\/p>\n

V\u1edbi s\u1ef1 ra \u0111\u1eddi c\u1ee7a li\u1ec7u ph\u00e1p kh\u00f4ng thay th\u1ebf y\u1ebfu t\u1ed1 nh\u01b0 emicizumab, c\u00e1c ph\u00f2ng x\u00e9t nghi\u1ec7m tr\u01b0\u1edbc ti\u00ean c\u1ea7n hi\u1ec3u c\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a li\u1ec7u ph\u00e1p v\u00e0 t\u00e1c \u0111\u1ed9ng sinh h\u00f3a \u0111\u1ed1i v\u1edbi c\u00e1c lo\u1ea1i x\u00e9t nghi\u1ec7m kh\u00e1c nhau. Sau \u0111\u00f3, h\u1ecd c\u00f3 th\u1ec3 ch\u1ecdn c\u00e1c x\u00e9t nghi\u1ec7m ph\u00f9 h\u1ee3p nh\u1ea5t \u0111\u1ec3 theo d\u00f5i:<\/p>\n

B\u1ea5t k\u1ec3 l\u1ef1a ch\u1ecdn li\u1ec7u ph\u00e1p n\u00e0o, kh\u1ea3 n\u0103ng ph\u00e1t tri\u1ec3n ch\u1ea5t \u1ee9c ch\u1ebf v\u1eabn c\u00f2n t\u1ed3n t\u1ea1i. C\u00e1c ph\u00f2ng x\u00e9t nghi\u1ec7m l\u00e2m s\u00e0ng c\u1ea7n theo d\u00f5i s\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a ch\u1ea5t \u1ee9c ch\u1ebf v\u00ec ch\u00fang \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn hi\u1ec7u qu\u1ea3 c\u1ee7a li\u1ec7u ph\u00e1p. Sau \u0111\u00e2y l\u00e0 m\u1ed9t s\u1ed1 \u0111i\u1ec3m c\u1ea7n l\u01b0u \u00fd khi x\u00e9t nghi\u1ec7m ch\u1ea5t \u1ee9c ch\u1ebf.<\/p>\n

M\u1eb7c d\u00f9 li\u1ec7u ph\u00e1p thay th\u1ebf d\u01b0\u1edbi d\u1ea1ng c\u00e1c s\u1ea3n ph\u1ea9m y\u1ebfu t\u1ed1 t\u00e1ch t\u1eeb huy\u1ebft t\u01b0\u01a1ng v\u00e0 t\u00e1i t\u1ed5 h\u1ee3p v\u1eabn l\u00e0 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb h\u00e0ng \u0111\u1ea7u cho b\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng hi\u1ec7n nay nh\u01b0ng nghi\u00ean c\u1ee9u \u0111\u1ea7y h\u1ee9a h\u1eb9n v\u1eabn \u0111ang \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh \u0111\u1ec3 kh\u00e1m ph\u00e1 ra c\u00e1c ch\u1ea5t m\u1edbi. C\u00e1c ch\u1ea5t n\u00e0y s\u1eed d\u1ee5ng c\u00e1c m\u1ee5c ti\u00eau thu\u1ed1c ph\u00e2n t\u1eed, gen v\u00e0 protein kh\u00e1c li\u00ean quan \u0111\u1ebfn qu\u00e1 tr\u00ecnh \u0111\u00f4ng m\u00e1u. K\u1ebft qu\u1ea3 \u0111\u00e3 l\u00e0m ta c\u00f3 th\u1ec3 h\u1ee3p l\u00fd l\u1ea1c quan r\u1eb1ng c\u00f3 th\u1ec3 t\u1ed3n t\u1ea1i con \u0111\u01b0\u1eddng ch\u1eefa kh\u1ecfi b\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng trong t\u01b0\u01a1ng lai g\u1ea7n [6].<\/p>\n

T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/em><\/p>\n

[1]<\/a> Centres for Disease Control and Prevention, Haemophilia Homepage-Inhibitors and Haemophilia https:\/\/www.cdc.gov\/ncbddd\/hemophilia\/inhibitors.html<\/p>\n

[2]<\/a> Mannucci, P., 2020. Hemophilia therapy: the future has begun. Haematologica, 105(3), pp.545-553.<\/p>\n

[3]<\/a> FDA approves emicizumab-kxwh for prevention and reduction of bleeding in patients with hemophilia A with factor VIII inhibitors. https:\/\/www.fda.gov\/drugs\/resources-information-approved-drugs\/fda-approves-emicizumab-kxwh-prevention-and-reduction-bleeding-patients-hemophilia-factor-viii<\/p>\n

[4]<\/a> CSL Behring gene therapy makes comeback after hold for FDA priority review. https:\/\/www.fiercebiotech.com\/biotech\/2020-trial-pause-isnt-holding-csl-behring-back-fda-oks-priority-review-application<\/p>\n

[5]<\/a> BioMarin\u2019s haemophilia gene therapy Roctavian wins conditional EU backing amid FDA delay. https:\/\/www.fiercepharma.com\/pharma\/biomarins-hemophilia-gene-therapy-roctavian-wins-conditional-eu-backing-fda-plan-delayed<\/p>\n

[6] <\/a>World Federation of Haemophilia Guidelines for the Management of Haemophilia. https:\/\/www1.wfh.org\/publications\/files\/pdf-1863.pdf<\/p>\n

[7]<\/a> National Haemophilia Foundation for all bleeding disorders-current treatments. https:\/\/www.hemophilia.org\/bleeding-disorders-a-z\/treatment\/current-treatments<\/p>\n

[8]<\/a> World Federation of Haemophilia Guidelines for the Management of Haemophilia. https:\/\/www1.wfh.org\/publications\/files\/pdf-1863.pdf<\/p>\n","protected":false},"excerpt":{"rendered":"

B\u00e0i vi\u1ebft n\u00e0y l\u00e0 ph\u1ea7n 2 trong lo\u1ea1t b\u00e0i v\u1ec1 ch\u1ea9n \u0111o\u00e1n v\u00e0 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng. B\u00e0i vi\u1ebft \u0111\u1ea7u ti\u00ean, c\u00f3 th\u1ec3 xem t\u1ea1i \u0111\u00e2y, cung c\u1ea5p c\u00e1i nh\u00ecn t\u1ed5ng quan v\u1ec1 bi\u1ec3u hi\u1ec7n l\u00e2m s\u00e0ng, ch\u1ea9n \u0111o\u00e1n v\u00e0 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh n\u00e0y. Khi c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u ph\u00e1t tri\u1ec3n c\u00e1c ph\u01b0\u01a1ng […]<\/p>\n","protected":false},"author":1,"featured_media":85546,"parent":0,"menu_order":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"tags":[14828,14793],"pillarandcategory":[294,292,282],"reporter":[14949,14950],"class_list":["post-147193","acf_article","type-acf_article","status-publish","has-post-thumbnail","hentry","tag-benh-hiem","tag-dong-mau","pillarandcategory-rare-diseases","pillarandcategory-coagulation","pillarandcategory-disease-area","reporter-niti-dawar","reporter-yingli-huang"],"acf":[],"_links":{"self":[{"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/acf_article\/147193","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/acf_article"}],"about":[{"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/types\/acf_article"}],"author":[{"embeddable":true,"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":3,"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/acf_article\/147193\/revisions"}],"predecessor-version":[{"id":149157,"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/acf_article\/147193\/revisions\/149157"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/media\/85546"}],"wp:attachment":[{"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/media?parent=147193"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/tags?post=147193"},{"taxonomy":"pillarandcategory","embeddable":true,"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/pillarandcategory?post=147193"},{"taxonomy":"reporter","embeddable":true,"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/reporter?post=147193"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}