{"id":147255,"date":"2021-10-13T07:21:10","date_gmt":"2021-10-13T07:21:10","guid":{"rendered":"https:\/\/labinsights.com\/acf_article\/do-luong-thuoc-chong-dong-duong-uong-truc-tiep-doac-va-cac-chat-uc-che-con-duong-tiep-xuc\/"},"modified":"2026-02-23T06:49:33","modified_gmt":"2026-02-23T06:49:33","slug":"measurement-of-direct-oral-anticoagulants-doacs-and-contact-pathway-inhibitors","status":"publish","type":"acf_article","link":"https:\/\/labinsights.com\/vi\/disease-area\/coagulation\/measurement-of-direct-oral-anticoagulants-doacs-and-contact-pathway-inhibitors\/","title":{"rendered":"\u0110o l\u01b0\u1ee3ng thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng \u0111\u01b0\u1eddng u\u1ed1ng tr\u1ef1c ti\u1ebfp (DOAC) v\u00e0 c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf con \u0111\u01b0\u1eddng ti\u1ebfp x\u00fac"},"content":{"rendered":"<p class=\"text-align-justify\">T\u1ea1i h\u1ed9i ngh\u1ecb chuy\u00ean \u0111\u1ec1 v\u1ec7 tinh do Roche Diagnostics t\u00e0i tr\u1ee3 \u2018\u2018T\u1eeb nghi\u00ean c\u1ee9u c\u01a1 b\u1ea3n \u0111\u1ebfn d\u1eef li\u1ec7u l\u00e2m s\u00e0ng: t\u01b0\u01a1ng lai c\u1ee7a c\u00f4ng t\u00e1c qu\u1ea3n l\u00fd b\u1ec7nh nh\u00e2n\u2019\u2019 \u0111\u01b0\u1ee3c t\u1ed5 ch\u1ee9c trong \u0111\u1ea1i h\u1ed9i Qu\u1ed1c t\u1ebf v\u1ec1 C\u1ea7m m\u00e1u (ISTH) 2021, Gi\u00e1o s\u01b0 Jonathan Douxfils \u0111\u00e3 th\u1ea3o lu\u1eadn v\u1ec1 gi\u00e1 tr\u1ecb c\u1ee7a vi\u1ec7c theo d\u00f5i thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng m\u00e1u \u0111\u01b0\u1eddng u\u1ed1ng tr\u1ef1c ti\u1ebfp (DOAC) v\u00e0 c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf con \u0111\u01b0\u1eddng ti\u1ebfp x\u00fac.<\/p>\n<p class=\"text-align-justify\">M\u1eb7c d\u00f9 DOAC \u0111\u00e3 \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n m\u00e0 kh\u00f4ng c\u1ea7n ph\u1ea3i theo d\u00f5i x\u00e9t nghi\u1ec7m th\u01b0\u1eddng quy, nh\u01b0ng vi\u1ec7c \u0111\u00e1nh gi\u00e1 ph\u01a1i nhi\u1ec5m thu\u1ed1c v\u00e0 t\u00e1c d\u1ee5ng ch\u1ed1ng \u0111\u00f4ng m\u00e1u r\u1ea5t h\u1eefu \u00edch trong m\u1ed9t s\u1ed1 t\u00ecnh hu\u1ed1ng l\u00e2m s\u00e0ng nh\u1ea5t \u0111\u1ecbnh. V\u00ed d\u1ee5, Gi\u00e1o s\u01b0 Douxfils \u0111\u00e3 nh\u1ea5n m\u1ea1nh t\u1ea7m quan tr\u1ecdng c\u1ee7a vi\u1ec7c theo d\u00f5i n\u1ed3ng \u0111\u1ed9 DOAC trong huy\u1ebft t\u01b0\u01a1ng \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 ch\u1ea3y m\u00e1u ho\u1eb7c t\u00e1i ph\u00e1t huy\u1ebft kh\u1ed1i, c\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 cho th\u1ea5y m\u1ed1i li\u00ean quan gi\u1eefa n\u1ed3ng \u0111\u1ed9 DOAC trong huy\u1ebft t\u01b0\u01a1ng cao h\u01a1n v\u00e0 c\u00e1c bi\u1ebfn ch\u1ee9ng ch\u1ea3y m\u00e1u m\u00e0 kh\u00f4ng c\u1ea7n b\u1ea3o v\u1ec7 huy\u1ebft kh\u1ed1i b\u1ed5 sung. Trong s\u1ed1 c\u00e1c b\u1ec7nh nh\u00e2n d\u00f9ng DOAC, c\u00e1c ph\u00e2n t\u00edch g\u1ea7n \u0111\u00e2y \u0111\u00e3 ph\u00e1t hi\u1ec7n th\u1ea5y t\u1ef7 l\u1ec7 xu\u1ea5t huy\u1ebft bi\u1ebfn c\u1ed1 cao h\u01a1n \u1edf nh\u1eefng ng\u01b0\u1eddi \u0111\u00e1p \u1ee9ng cao v\u00e0 bi\u1ebfn c\u1ed1 huy\u1ebft kh\u1ed1i \u1edf nh\u1eefng ng\u01b0\u1eddi \u0111\u00e1p \u1ee9ng th\u1ea5p. V\u1edbi s\u1ef1 kh\u00e1c bi\u1ec7t gi\u1eefa c\u00e1c c\u00e1 th\u1ec3 n\u00e0y, theo d\u00f5i ch\u1ed1ng \u0111\u00f4ng m\u00e1u c\u00f3 th\u1ec3 cho ph\u00e9p qu\u1ea3n l\u00fd c\u00e1 nh\u00e2n \u0111\u1ec3 t\u1ed1i \u01b0u h\u00f3a k\u1ebft qu\u1ea3 c\u1ee7a b\u1ec7nh nh\u00e2n. C\u00e1c b\u1ed1i c\u1ea3nh l\u00e2m s\u00e0ng kh\u00e1c m\u00e0 vi\u1ec7c \u0111o l\u01b0\u1eddng DOACs (thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng \u0111\u01b0\u1eddng u\u1ed1ng tr\u1ef1c ti\u1ebfp) c\u00f3 \u00fd ngh\u0129a bao g\u1ed3m tr\u01b0\u1edbc c\u00e1c th\u1ee7 thu\u1eadt x\u00e2m l\u1ea5n, bao g\u1ed3m c\u1ea3 ph\u1eabu thu\u1eadt kh\u1ea9n c\u1ea5p, \u0111\u1ec3 h\u01b0\u1edbng d\u1eabn vi\u1ec7c s\u1eed d\u1ee5ng thu\u1ed1c gi\u1ea3i \u0111\u1ed9c v\u00e0 c\u0169ng \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc kh\u00f4ng th\u1ec3 d\u1ef1 \u0111o\u00e1n, ch\u1eb3ng h\u1ea1n nh\u01b0 nh\u1eefng ng\u01b0\u1eddi c\u00f3 tr\u1ecdng l\u01b0\u1ee3ng c\u01a1 th\u1ec3 c\u1ef1c k\u1ef3 cao ho\u1eb7c th\u1ea5p. \u0110\u1ec3 \u0111\u01b0\u1ee3c h\u01b0\u1edbng d\u1eabn chi ti\u1ebft v\u1ec1 x\u00e9t nghi\u1ec7m \u0111o l\u01b0\u1eddng DOAC, vui l\u00f2ng xem c\u00e1c khuy\u1ebfn ngh\u1ecb t\u1eeb H\u1ed9i \u0111\u1ed3ng Ti\u00eau chu\u1ea9n h\u00f3a Qu\u1ed1c t\u1ebf trong Huy\u1ebft h\u1ecdc [1,2].<\/p>\n<p class=\"text-align-justify\">Ch\u1ea5t \u1ee9c ch\u1ebf con \u0111\u01b0\u1eddng ti\u1ebfp x\u00fac, th\u01b0\u1eddng h\u01b0\u1edbng \u0111\u00edch \u0111\u1ebfn c\u00e1c Y\u1ebfu t\u1ed1 XI ho\u1eb7c XII \u0111\u00f3ng m\u1ed9t vai tr\u00f2 quan tr\u1ecdng trong huy\u1ebft kh\u1ed1i, \u0111\u1ea1i di\u1ec7n cho c\u00e1c li\u1ec7u ph\u00e1p ch\u1ed1ng \u0111\u00f4ng m\u00e1u m\u1edbi \u0111\u1ea7y h\u1ee9a h\u1eb9n. V\u00f4 s\u1ed1 chi\u1ebfn l\u01b0\u1ee3c \u1ee9c ch\u1ebf Y\u1ebfu t\u1ed1 XI\/XII \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111\u1ec1 xu\u1ea5t bao g\u1ed3m s\u1eed d\u1ee5ng c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf peptit ho\u1eb7c peptit nh\u1ecf, kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng, oligonucleotit \u0111\u1ed1i ngh\u0129a v\u00e0 aptame. Do Y\u1ebfu t\u1ed1 XI \u0111\u01b0\u1ee3c ho\u1ea1t h\u00f3a b\u1edfi thrombin v\u00e0 \u0111\u00f3ng m\u1ed9t vai tr\u00f2 trong vi\u1ec7c khu\u1ebfch \u0111\u1ea1i th\u1ebf h\u1ec7 thrombin, c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf Y\u1ebfu t\u1ed1 XI nh\u01b0 osocimab c\u00f3 li\u00ean quan \u0111\u1ebfn t\u1ef7 l\u1ec7 ch\u1ea3y m\u00e1u t\u01b0\u01a1ng \u0111\u01b0\u01a1ng v\u1edbi enoxaparin v\u00e0 cao h\u01a1n apixaban, do \u0111\u00f3, c\u1ea7n c\u00f3 th\u00eam b\u1eb1ng ch\u1ee9ng \u0111\u1ec3 xem c\u00f3 th\u1ec3 k\u1ebft h\u1ee3p gi\u00e1m s\u00e1t sinh h\u1ecdc th\u01b0\u1eddng quy ho\u1eb7c th\u1ec9nh tho\u1ea3ng hay kh\u00f4ng. Vi\u1ec7c ph\u00e1t tri\u1ec3n c\u00e1c x\u00e9t nghi\u1ec7m \u0111\u1eb7c hi\u1ec7u c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c khuy\u1ebfn ngh\u1ecb cho nh\u1eefng t\u00e1c nh\u00e2n \u0111i\u1ec1u tr\u1ecb m\u1edbi n\u00e0y, v\u1edbi c\u00e1c ph\u01b0\u01a1ng ph\u00e1p c\u00f3 th\u1ec3 d\u1ef1a tr\u00ean ph\u00e1t hi\u1ec7n chromogenic, fluorogenic, x\u00e9t nghi\u1ec7m \u0111\u00f4ng m\u00e1u, ph\u00e1t hi\u1ec7n kh\u00e1ng nguy\u00ean v\u00e0 c\u00e1c x\u00e9t nghi\u1ec7m to\u00e0n c\u1ee5c v\u1ec1 \u0111\u00f4ng m\u00e1u.<\/p>\n<p class=\"text-align-justify\">T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/p>\n<p class=\"text-align-justify\"><a href=\"https:\/\/www.thieme-connect.com\/products\/ejournals\/html\/10.1055\/s-0038-1627480\" target=\"_blank\" rel=\"noopener\">[1]<\/a> Gosselin RC, et al. Thromb Haemost 2018;118:437-450<\/p>\n<p class=\"text-align-justify\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33742436\/\" target=\"_blank\" rel=\"noopener\">[2]<\/a> Douxfils J, et al. Thromb Haemost 2021;121:1008\u20131020.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>T\u1ea1i h\u1ed9i ngh\u1ecb chuy\u00ean \u0111\u1ec1 v\u1ec7 tinh do Roche Diagnostics t\u00e0i tr\u1ee3 \u2018\u2018T\u1eeb nghi\u00ean c\u1ee9u c\u01a1 b\u1ea3n \u0111\u1ebfn d\u1eef li\u1ec7u l\u00e2m s\u00e0ng: t\u01b0\u01a1ng lai c\u1ee7a c\u00f4ng t\u00e1c qu\u1ea3n l\u00fd b\u1ec7nh nh\u00e2n\u2019\u2019 \u0111\u01b0\u1ee3c t\u1ed5 ch\u1ee9c trong \u0111\u1ea1i h\u1ed9i Qu\u1ed1c t\u1ebf v\u1ec1 C\u1ea7m m\u00e1u (ISTH) 2021, Gi\u00e1o s\u01b0 Jonathan Douxfils \u0111\u00e3 th\u1ea3o lu\u1eadn v\u1ec1 gi\u00e1 tr\u1ecb c\u1ee7a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":90639,"parent":0,"menu_order":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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