{"id":147324,"date":"2021-03-16T03:27:44","date_gmt":"2021-03-16T03:27:44","guid":{"rendered":"https:\/\/labinsights.com\/acf_article\/ngs-next-generation-sequencing-giai-trinh-gen-the-he-moi-va-tinh-chinh-xac-trong-ung-thu-hoc-tai-uc-thong-tin-chi-tiet-tu-giao-su-peter-gibbs-va-svetlana-cherepanoff\/"},"modified":"2026-02-24T10:18:58","modified_gmt":"2026-02-24T10:18:58","slug":"ngs-and-precision-oncology-in-australia-insights-from-profs-peter-gibbs-and-svetlana-cherepanoff","status":"publish","type":"acf_article","link":"https:\/\/labinsights.com\/vi\/operations\/clinical-decision-support\/ngs-and-precision-oncology-in-australia-insights-from-profs-peter-gibbs-and-svetlana-cherepanoff\/","title":{"rendered":"NGS (Next-Generation Sequencing, gi\u1ea3i tr\u00ecnh gen th\u1ebf h\u1ec7 m\u1edbi) v\u00e0 ti\u0301nh chi\u0301nh xa\u0301c trong ung th\u01b0 ho\u0323c t\u1ea1i \u00dac: Th\u00f4ng tin chi ti\u1ebft t\u1eeb Gi\u00e1o s\u01b0 Peter Gibbs v\u00e0 Svetlana Cherepanoff"},"content":{"rendered":"

B\u00e0i vi\u1ebft n\u00e0y l\u00e0 m\u1ed9t ph\u1ea7n c\u1ee7a lo\u1ea1t nghi\u00ean c\u1ee9u \u0111i\u1ec3n h\u00ecnh v\u1ec1 vi\u1ec7c s\u1eed d\u1ee5ng NGS (Next-Generation Sequencing, gi\u1ea3i tr\u00ecnh gen th\u1ebf h\u1ec7 m\u1edbi) v\u00e0 c\u00e1c c\u00f4ng c\u1ee5 k\u1ef9 thu\u1eadt s\u1ed1 \u0111\u1ec3 th\u00fac \u0111\u1ea9y ti\u0301nh chi\u0301nh xa\u0301c trong ung th\u01b0 ho\u0323c t\u1ea1i khu v\u1ef1c Ch\u00e2u \u00c1 – Th\u00e1i B\u00ecnh D\u01b0\u01a1ng. Vui l\u00f2ng cu\u1ed9n xu\u1ed1ng cu\u1ed1i b\u00e0i vi\u1ebft \u0111\u1ec3 xem danh s\u00e1ch \u0111\u1ea7y \u0111\u1ee7<\/em>.<\/p>\n

N\u0103m 2018, ch\u00ednh ph\u1ee7 \u00dac \u0111\u00e3 cam k\u1ebft \u0111\u1ea7u t\u01b0 500 tri\u1ec7u \u0111\u00f4 la trong 10 n\u0103m cho nghi\u00ean c\u1ee9u h\u1ec7 gen. V\u1edbi ti\u1ec1m n\u0103ng to l\u1edbn trong vi\u1ec7c c\u1ea3i thi\u1ec7n ch\u1ea9n \u0111o\u00e1n b\u1ec7nh v\u00e0 th\u00fac \u0111\u1ea9y y h\u1ecdc c\u00e1 nh\u00e2n h\u00f3a, gi\u1ea3i tr\u00ecnh t\u1ef1 gen th\u1ebf h\u1ec7 m\u1edbi (NGS) v\u00e0 c\u00e1c x\u00e9t nghi\u1ec7m h\u1ec7 gen kh\u00e1c hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n tr\u00ean to\u00e0n qu\u1ed1c t\u1ea1i c\u1ea3 c\u00e1c ph\u00f2ng th\u00ed nghi\u1ec7m t\u01b0 nh\u00e2n v\u00e0 do ch\u00ednh ph\u1ee7 t\u00e0i tr\u1ee3. Tuy nhi\u00ean, h\u1ea7u h\u1ebft c\u00e1c d\u1ea5u \u1ea5n sinh h\u1ecdc \u0111\u01b0\u1ee3c x\u00e9t nghi\u1ec7m ri\u00eang l\u1ebb v\u00e0 ch\u1ec9 khi c\u00f3 li\u00ean quan, thay v\u00ec x\u00e9t nghi\u1ec7m tr\u01b0\u1edbc v\u00e0 \u0111\u1ecbnh k\u1ef3.<\/p>\n

Gi\u00e1o s\u01b0 Peter Gibbs, chuy\u00ean gia ung th\u01b0 \u0111\u1ea1i tr\u1ef1c tr\u00e0ng t\u1ea1i Vi\u1ec7n Nghi\u00ean c\u1ee9u Y khoa Walter v\u00e0 Eliza Hall \u1edf Victoria, v\u00e0 Gi\u00e1o s\u01b0 Svetlana Cherepanoff, b\u00e1c s\u0129 m\u00f4 b\u1ec7nh h\u1ecdc m\u1eaft t\u1ea1i B\u1ec7nh vi\u1ec7n St. Vincent v\u00e0 SydPath \u1edf New South Wales, \u0111\u1ec1u l\u00e0m vi\u1ec7c t\u1ea1i giao \u0111i\u1ec3m gi\u1eefa nghi\u00ean c\u1ee9u v\u00e0 y h\u1ecdc ch\u1ea9n \u0111o\u00e1n. H\u1ecd \u0111\u00e3 trao \u0111\u1ed5i v\u1edbi ch\u00fang t\u00f4i v\u1ec1 c\u00e1c v\u1ea5n \u0111\u1ec1 li\u00ean quan \u0111\u1ebfn vi\u1ec7c t\u00edch h\u1ee3p NGS (Next-Generation Sequencing, gi\u1ea3i tr\u00ecnh gen th\u1ebf h\u1ec7 m\u1edbi) trong l\u00e2m s\u00e0ng t\u1ea1i \u00dac.<\/p>\n

NGS (Next-Generation Sequencing, gi\u1ea3i tr\u00ecnh gen th\u1ebf h\u1ec7 m\u1edbi) v\u00e0 MTBs (molecular tumour boards, Ca\u0301c h\u1ed9i \u0111\u1ed3ng v\u00ea\u0300 kh\u1ed1i u c\u00e2\u0301p \u0111\u00f4\u0323 ph\u00e2n t\u1eed) trong th\u1ef1c h\u00e0nh l\u00e2m s\u00e0ng<\/h3>\n

M\u1eb7c d\u00f9 NGS (Next-Generation Sequencing, gi\u1ea3i tr\u00ecnh gen th\u1ebf h\u1ec7 m\u1edbi) ng\u00e0y c\u00e0ng \u0111\u01b0\u1ee3c quan t\u00e2m, nh\u01b0ng c\u00e1c b\u00e1c s\u0129 ung th\u01b0 \u00dac trung b\u00ecnh l\u1ea1i c\u00f3 \u00edt kinh nghi\u1ec7m v\u1edbi c\u00e1c c\u00f4ng c\u1ee5 v\u00e0 ph\u01b0\u01a1ng ph\u00e1p m\u1edbi nh\u1ea5t. Medicare, ch\u01b0\u01a1ng tr\u00ecnh ch\u0103m s\u00f3c s\u1ee9c kh\u1ecfe to\u00e0n d\u00e2n qu\u1ed1c gia c\u1ee7a \u00dac, ch\u1ec9 chi tr\u1ea3 cho c\u00e1c x\u00e9t nghi\u1ec7m NGS (Next-Generation Sequencing, gi\u1ea3i tr\u00ecnh gen th\u1ebf h\u1ec7 m\u1edbi) cho c\u00e1c giai \u0111o\u1ea1n ho\u1eb7c lo\u1ea1i ung th\u01b0 c\u1ee5 th\u1ec3 nh\u01b0 u h\u1eafc t\u1ed1 da, ung th\u01b0 ph\u1ed5i ho\u1eb7c ung th\u01b0 bi\u1ec3u m\u00f4 kh\u00f4ng ph\u1ea3i t\u1ebf b\u00e0o nh\u1ecf v\u00e0 ung th\u01b0 \u0111\u1ea1i tr\u1ef1c tr\u00e0ng. Gi\u1edbi h\u1ea1n chi tr\u1ea3 cho c\u00e1c x\u00e9t nghi\u1ec7m NGS (Next-Generation Sequencing, gi\u1ea3i tr\u00ecnh gen th\u1ebf h\u1ec7 m\u1edbi) kh\u00e1c nhau \u0111\u1ed3ng ngh\u0129a v\u1edbi vi\u1ec7c c\u00e1c b\u1ea3ng NGS (Next-Generation Sequencing, gi\u1ea3i tr\u00ecnh gen th\u1ebf h\u1ec7 m\u1edbi) nh\u1ecf h\u01a1n, r\u1ebb h\u01a1n v\u00e0 nh\u1eafm m\u1ee5c ti\u00eau ch\u00ednh x\u00e1c h\u01a1n \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng th\u01b0\u1eddng xuy\u00ean h\u01a1n so v\u1edbi c\u00e1c b\u1ea3ng l\u1edbn h\u01a1n, \u0111\u1eaft h\u01a1n v\u00e0 to\u00e0n di\u1ec7n h\u01a1n.<\/p>\n

\u0110\u1ed1i v\u1edbi c\u00e1c tr\u01b0\u1eddng h\u1ee3p ph\u1ee9c t\u1ea1p s\u1eed d\u1ee5ng c\u00e1c ph\u01b0\u01a1ng ph\u00e1p ch\u1ea9n \u0111o\u00e1n m\u1edbi, h\u1ed9i \u0111\u1ed3ng kh\u1ed1i u ph\u00e2n t\u1eed (MTBs) mang \u0111\u1ebfn c\u01a1 h\u1ed9i chia s\u1ebb chuy\u00ean m\u00f4n. M\u1ed9t MTB (molecular tumour board, H\u1ed9i \u0111\u1ed3ng v\u00ea\u0300 kh\u1ed1i u c\u00e2\u0301p \u0111\u00f4\u0323 ph\u00e2n t\u1eed) c\u00f3 th\u1ec3 bao g\u1ed3m c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u, k\u1ef9 thu\u1eadt vi\u00ean x\u00e9t nghi\u1ec7m, b\u00e1c s\u0129 ung th\u01b0 v\u00e0 b\u00e1c s\u0129 b\u1ec7nh h\u1ecdc, c\u00f9ng nhau th\u1ea3o lu\u1eadn c\u00e1c ch\u1ee7 \u0111\u1ec1 nh\u01b0 h\u01b0\u1edbng d\u1eabn gi\u00e1m s\u00e1t, ph\u00e2n lo\u1ea1i b\u1ec7nh, k\u1ebft qu\u1ea3 m\u1ea3ng v\u00e0 NGS (Next-Generation Sequencing, gi\u1ea3i tr\u00ecnh gen th\u1ebf h\u1ec7 m\u1edbi). Tuy nhi\u00ean, r\u1ea5t \u00edt b\u00e1c s\u0129 l\u00e2m s\u00e0ng \u00dac c\u00f3 th\u1ec3 ti\u1ebfp c\u1eadn \u0111\u01b0\u1ee3c m\u1ed9t trong s\u1ed1 nh\u1eefng h\u1ed9i \u0111\u1ed3ng n\u00e0y ho\u1eb7c c\u00f3 ki\u1ebfn th\u1ee9c \u0111\u1ec3 tham gia hi\u1ec7u qu\u1ea3. Gi\u00e1o s\u01b0 Gibbs cho bi\u1ebft: “C\u1ea7n r\u1ea5t nhi\u1ec1u gi\u00e1o d\u1ee5c \u0111\u1ec3 \u0111\u01b0a MTBs (molecular tumour boards, Ca\u0301c h\u1ed9i \u0111\u1ed3ng v\u00ea\u0300 kh\u1ed1i u c\u00e2\u0301p \u0111\u00f4\u0323 ph\u00e2n t\u1eed) tr\u1edf th\u00e0nh ho\u1ea1t \u0111\u1ed9ng th\u01b0\u1eddng quy trong b\u1ec7nh vi\u1ec7n”.<\/p>\n

Gi\u00e1o s\u01b0 Cherepanoff, ng\u01b0\u1eddi \u0111i\u1ec1u h\u00e0nh nh\u00f3m MTB (molecular tumour board, H\u1ed9i \u0111\u1ed3ng v\u00ea\u0300 kh\u1ed1i u c\u00e2\u0301p \u0111\u00f4\u0323 ph\u00e2n t\u1eed) duy nh\u1ea5t v\u1ec1 ung th\u01b0 m\u1eaft t\u1ea1i \u00dac, \u0111\u00e3 c\u00f3 kinh nghi\u1ec7m tr\u1ef1c ti\u1ebfp v\u1ec1 l\u1ee3i \u00edch c\u1ee7a s\u1ef1 h\u1ee3p t\u00e1c \u0111a ng\u00e0nh. V\u00ed d\u1ee5, m\u1ed9t MTB (molecular tumour board, H\u1ed9i \u0111\u1ed3ng v\u00ea\u0300 kh\u1ed1i u c\u00e2\u0301p \u0111\u00f4\u0323 ph\u00e2n t\u1eed) cho b\u1ec7nh u h\u1eafc t\u1ed1 m\u00e0ng b\u1ed3 \u0111\u00e0o \u0111\u00e3 t\u00edch h\u1ee3p th\u00e0nh c\u00f4ng th\u00f4ng tin t\u1eeb h\u00ecnh \u1ea3nh l\u00e2m s\u00e0ng, m\u1ea3ng SNP (Single Nucleotide Polymorphism, \u0110a h\u00ecnh m\u1ed9t nucleotide) cho nh\u1eefng thay \u0111\u1ed5i s\u1ed1 l\u01b0\u1ee3ng b\u1ea3n sao nhi\u1ec5m s\u1eafc th\u1ec3 v\u00e0 NGS (Next-Generation Sequencing, gi\u1ea3i tr\u00ecnh gen th\u1ebf h\u1ec7 m\u1edbi). \u0110i\u1ec1u n\u00e0y \u0111\u00e3 truy\u1ec1n c\u1ea3m h\u1ee9ng cho SydPath n\u1ed9p \u0111\u01a1n xin t\u00e0i tr\u1ee3 \u0111\u1ec3 bi\u1ebfn m\u00f4 h\u00ecnh MTB n\u00e0y th\u00e0nh m\u1ed9t m\u00f4 h\u00ecnh t\u1ef1 duy tr\u00ec.<\/p>\n

X\u00e9t nghi\u1ec7m d\u1ea5u \u1ea5n sinh h\u1ecdc so v\u1edbi NGS (Next-Generation Sequencing, gi\u1ea3i tr\u00ecnh gen th\u1ebf h\u1ec7 m\u1edbi)<\/h3>\n

X\u00e9t nghi\u1ec7m NGS (Next-Generation Sequencing, gi\u1ea3i tr\u00ecnh gen th\u1ebf h\u1ec7 m\u1edbi) c\u00f3 th\u1ec3 tr\u1edf th\u00e0nh th\u01b0\u1eddng quy v\u00e0 \u0111\u01b0\u1ee3c \u01b0u ti\u00ean trong ung th\u01b0 h\u1ecdc n\u1ebfu n\u00f3 ch\u1ee9ng minh \u0111\u01b0\u1ee3c hi\u1ec7u qu\u1ea3 v\u00e0 cung c\u1ea5p th\u00f4ng tin t\u1ed1t h\u01a1n so v\u1edbi c\u00e1c x\u00e9t nghi\u1ec7m ch\u1ec9 \u0111i\u1ec3m sinh h\u1ecdc \u0111\u01a1n l\u1ebb, nh\u01b0 \u0111\u00e3 x\u1ea3y ra v\u1edbi ung th\u01b0 ph\u1ed5i. \u0110\u1ed1i v\u1edbi ung th\u01b0 \u0111\u1ea1i tr\u1ef1c tr\u00e0ng, Gi\u00e1o s\u01b0 Gibbs ch\u1ec9 t\u00ecm ki\u1ebfm m\u1ed9t s\u1ed1 \u00edt c\u00e1c ch\u1ec9 \u0111i\u1ec3m sinh h\u1ecdc c\u00f3 kh\u1ea3 n\u0103ng d\u1ef1 \u0111o\u00e1n v\u00e0 ti\u00ean l\u01b0\u1ee3ng \u0111\u01b0\u1ee3c ho\u00e0n tr\u1ea3, nh\u01b0ng l\u01b0u \u00fd r\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p n\u00e0y c\u00f3 th\u1ec3 s\u1ebd k\u00e9m hi\u1ec7u qu\u1ea3 v\u1ec1 m\u1eb7t chi ph\u00ed h\u01a1n khi c\u00f3 th\u00eam nhi\u1ec1u ch\u1ec9 \u0111i\u1ec3m sinh h\u1ecdc \u0111\u01b0\u1ee3c b\u1ed5 sung.<\/p>\n

Ph\u00f2ng xe\u0301t nghi\u1ec7m c\u1ee7a Gi\u00e1o s\u01b0 Cherepanoff t\u1ea1i SydPath cung c\u1ea5p b\u1ea3ng \u0111i\u1ec3m n\u00f3ng 50 gen \u0111\u00e3 \u0111\u01b0\u1ee3c x\u00e1c th\u1ef1c v\u00e0 c\u00f4ng nh\u1eadn, ch\u1ec9 ph\u00e1t hi\u1ec7n c\u00e1c gen “ng\u1eafn”, nh\u1eafm m\u1ee5c ti\u00eau trong ung th\u01b0 \u0111\u1ea1i tr\u1ef1c tr\u00e0ng, u h\u1eafc t\u1ed1 da v\u00e0 ung th\u01b0 ph\u1ed5i kh\u00f4ng t\u1ebf b\u00e0o nh\u1ecf. M\u1eb7c d\u00f9 \u0111\u01b0\u1ee3c chi tr\u1ea3, x\u00e9t nghi\u1ec7m n\u00e0y \u00edt h\u1eefu \u00edch h\u01a1n \u0111\u1ed1i v\u1edbi c\u00e1c kh\u1ed1i u hi\u1ebfm g\u1eb7p nh\u01b0 u h\u1eafc t\u1ed1 k\u1ebft m\u1ea1c (kh\u00f4ng c\u00f3 b\u1ea3ng NGS {Next-Generation Sequencing, gi\u1ea3i tr\u00ecnh gen th\u1ebf h\u1ec7 m\u1edbi} n\u00e0o d\u00e0nh cho c\u00e1c kh\u1ed1i u n\u00e0y), ho\u1eb7c trong vi\u1ec7c t\u00ecm ki\u1ebfm c\u00e1c m\u1ee5c ti\u00eau thu\u1ed1c v\u00e0 li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00f4ng ph\u1ee5 thu\u1ed9c v\u00e0o kh\u1ed1i u.<\/p>\n

Gi\u00e1o s\u01b0 Cherepanoff c\u0169ng \u0111ang ph\u00e1t tri\u1ec3n m\u1ed9t b\u1ea3ng d\u01b0\u0303 li\u00ea\u0323u l\u01a1\u0301n h\u01a1n v\u01a1\u0301i 161 gen, bao g\u1ed3m c\u00e1c b\u1ea3n sao mRNA (Messenger RNA, RNA th\u00f4ng tin), nh\u01b0ng b\u00e0 bi\u1ebft r\u1eb1ng c\u00e1c b\u00e1c s\u0129 c\u00f3 \u00edt th\u1eddi gian \u0111\u1ec3 x\u1eed l\u00fd l\u01b0\u1ee3ng th\u00f4ng tin kh\u1ed5ng l\u1ed3 na\u0300y v\u00e0 nh\u01b0\u0303ng nha\u0300 nghi\u00ean c\u01b0\u0301u ch\u1ec9 mu\u1ed1n ti\u0300m ra c\u00e1c m\u1ee5c ti\u00eau co\u0301 th\u00ea\u0309 ta\u0301c \u0111\u00f4\u0323ng \u0111\u01b0\u01a1\u0323c s\u1ebd kh\u00f3 c\u00f3 th\u1ec3 ti\u00ea\u0301p nh\u1eadn l\u01b0\u1ee3ng d\u1eef li\u1ec7u kh\u1ed5ng l\u1ed3 n\u00e0y. C\u00e1c b\u1ea3ng d\u01b0\u0303 li\u00ea\u0323u l\u1edbn h\u01a1n nh\u01b0 th\u1ebf n\u00e0y c\u00f3 nhi\u1ec1u kh\u1ea3 n\u0103ng \u0111\u01b0\u1ee3c cung c\u1ea5p th\u01b0\u1eddng xuy\u00ean b\u1edfi c\u00e1c b\u1ec7nh vi\u1ec7n v\u00e0 ph\u00f2ng th\u00ed nghi\u1ec7m l\u1edbn h\u01a1n. H\u01a1n n\u1eefa, nhi\u1ec1u ng\u01b0\u1eddi kh\u00f4ng th\u1ea5y vi\u1ec7c s\u1eed d\u1ee5ng c\u00e1c c\u00f4ng c\u1ee5 n\u00e0y cho t\u1ea5t c\u1ea3 b\u1ec7nh nh\u00e2n la\u0300 h\u01b0\u0303u i\u0301ch, v\u00ec v\u1eady ch\u1ec9 nh\u1eefng b\u1ec7nh nh\u00e2n tr\u1ebb, kh\u1ecfe m\u1ea1nh v\u00e0 tuy\u1ec7t v\u1ecdng m\u1edbi c\u00e2\u0300n s\u1eed d\u1ee5ng.<\/p>\n

Khi c\u00e1c n\u1ec1n t\u1ea3ng v\u00e0 b\u00e1o c\u00e1o \u0111\u01b0\u1ee3c c\u1ea3i thi\u1ec7n v\u1ec1 t\u00ednh th\u00e2n thi\u1ec7n v\u1edbi ng\u01b0\u1eddi d\u00f9ng v\u00e0 kh\u1ea3 n\u0103ng chi tr\u1ea3, c\u00f9ng v\u1edbi vi\u1ec7c t\u00edch l\u0169y th\u00eam kinh nghi\u1ec7m, NGS (Next-Generation Sequencing, gi\u1ea3i tr\u00ecnh gen th\u1ebf h\u1ec7 m\u1edbi) b\u1ea3ng nh\u1ecf cho kh\u1ed1i u \u0111\u0103\u0323c \u0111\u01b0\u01a1\u0323c mong ch\u01a1\u0300 la\u0300 s\u1ebd tr\u1edf tha\u0300nh xe\u0301t nghi\u00ea\u0323m th\u01b0\u01a1\u0300ng quy. C\u00e1c b\u00e1o c\u00e1o NGS (Next-Generation Sequencing, gi\u1ea3i tr\u00ecnh gen th\u1ebf h\u1ec7 m\u1edbi) n\u00e2ng cao cung c\u1ea5p c\u00e1c ph\u00e2n t\u00edch b\u1eadc ba, ch\u1eb3ng h\u1ea1n nh\u01b0 b\u00e1o c\u00e1o c\u1ee7a d\u1ecbch v\u1ee5 b\u1ec7nh h\u1ecdc Ho\u00e0ng gia Ho\u00e0ng t\u1eed Alfred t\u1ea1i Sydney, s\u1ebd \u0111\u01b0\u1ee3c s\u0103n \u0111\u00f3n. C\u00f4ng tr\u00ecnh l\u1eadp h\u1ed3 s\u01a1 ph\u00e2n t\u1eed th\u1ea7n kinh ung th\u01b0 c\u1ee7a Gi\u00e1o s\u01b0 Cherepanoff s\u1eed d\u1ee5ng n\u00f3 \u0111\u1ec3 t\u1ea1o ra c\u00e1c b\u00e1o c\u00e1o v\u00e0 t\u00f3m t\u1eaft s\u00e2u s\u1eafc t\u1eeb c\u00e1c t\u00e0i li\u1ec7u g\u1ea7n \u0111\u00e2y v\u00e0 c\u00e1c \u0111\u1ed9t bi\u1ebfn li\u00ean quan.<\/p>\n

C\u00f4ng c\u1ee5 k\u1ef9 thu\u1eadt s\u1ed1 v\u00e0 t\u01b0\u01a1ng lai c\u1ee7a MTBs (molecular tumour boards, Ca\u0301c h\u1ed9i \u0111\u1ed3ng v\u00ea\u0300 kh\u1ed1i u c\u00e2\u0301p \u0111\u00f4\u0323 ph\u00e2n t\u1eed)<\/h3>\n

Trong 5\u201310 n\u0103m t\u1edbi, Gi\u00e1o s\u01b0 Cherepanoff k\u1ef3 v\u1ecdng c\u00e1c c\u00f4ng c\u1ee5 k\u1ef9 thu\u1eadt s\u1ed1 ph\u1ee5c v\u1ee5 qu\u1ea3n l\u00fd quy tr\u00ecnh l\u00e0m vi\u1ec7c, chia s\u1ebb th\u00f4ng tin v\u00e0 h\u1ed7 tr\u1ee3 quy\u1ebft \u0111\u1ecbnh l\u00e2m s\u00e0ng s\u1ebd ph\u00e1t tri\u1ec3n nhanh ch\u00f3ng. Hi\u1ec7n t\u1ea1i, c\u00e1c c\u00f4ng c\u1ee5 m\u1edbi \u0111ang \u0111\u1ea3m b\u1ea3o c\u00e1c nh\u00f3m l\u00e0m vi\u1ec7c \u0111a d\u1ea1ng v\u1ec1 m\u1eb7t \u0111\u1ecba l\u00fd c\u00f3 th\u1ec3 h\u1ee3p t\u00e1c hi\u1ec7u qu\u1ea3 v\u00e0 b\u1ec7nh nh\u00e2n \u1edf v\u00f9ng s\u00e2u v\u00f9ng xa c\u00f3 th\u1ec3 ti\u1ebfp c\u1eadn d\u1ecbch v\u1ee5 ch\u0103m s\u00f3c t\u1ed1t h\u01a1n. Gi\u00e1o s\u01b0 Cherepanoff l\u01b0u \u00fd r\u1eb1ng c\u00e1c c\u00f4ng c\u1ee5 k\u1ef9 thu\u1eadt s\u1ed1 \u0111\u00e3 \u0111\u1ea9y nhanh nhi\u1ec1u quy tr\u00ecnh trong c\u00e1c MTBs (molecular tumour boards, Ca\u0301c h\u1ed9i \u0111\u1ed3ng v\u00ea\u0300 kh\u1ed1i u c\u00e2\u0301p \u0111\u00f4\u0323 ph\u00e2n t\u1eed) c\u1ee7a b\u00e0, t\u0103ng t\u1ea7n su\u1ea5t t\u1eeb ch\u1ec9 6 quy tr\u00ecnh m\u1ed7i n\u0103m l\u00ean 8 quy tr\u00ecnh trong v\u00f2ng 4 th\u00e1ng.<\/p>\n

Gi\u00e1o s\u01b0 Cherepanoff c\u0169ng l\u01b0u \u00fd r\u1eb1ng c\u00e1c c\u00f4ng c\u1ee5 k\u1ef9 thu\u1eadt s\u1ed1 \u0111ang gi\u00fap vi\u1ec7c xem v\u00e0 hi\u1ec3u kh\u1ed1i l\u01b0\u1ee3ng d\u1eef li\u1ec7u l\u1edbn tr\u1edf n\u00ean d\u1ec5 d\u00e0ng h\u01a1n. B\u00e0 hy v\u1ecdng c\u00e1c b\u00e1o c\u00e1o NGS (Next-Generation Sequencing, gi\u1ea3i tr\u00ecnh gen th\u1ebf h\u1ec7 m\u1edbi) c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c t\u00f9y ch\u1ec9nh \u0111\u1ec3 gi\u1ea3m thi\u1ec3u t\u00ecnh tr\u1ea1ng qu\u00e1 t\u1ea3i d\u1eef li\u1ec7u g\u00e2y kh\u00f3 kh\u0103n cho ng\u01b0\u1eddi d\u00f9ng \u00edt chuy\u00ean m\u00f4n, \u0111\u1ed3ng th\u1eddi gi\u00fap h\u1ecd tr\u00e1nh b\u1ecb thi\u1ebfu d\u1eef li\u1ec7u ho\u1eb7c b\u1ecf s\u00f3t c\u00e1c \u0111\u1eb7c \u0111i\u1ec3m ph\u00e2n t\u1eed quan tr\u1ecdng. B\u00e0 c\u0169ng hy v\u1ecdng r\u1eb1ng ch\u00fang ng\u00e0y c\u00e0ng th\u1ec3 hi\u1ec7n t\u00e1c \u0111\u1ed9ng ti\u00ean l\u01b0\u1ee3ng r\u00f5 r\u1ec7t h\u01a1n, v\u00e0 \u0111\u1eb7t m\u1ee5c ti\u00eau thu th\u1eadp d\u1eef li\u1ec7u th\u1eed nghi\u1ec7m tr\u00ean c\u00e1c c\u00f4ng c\u1ee5 n\u00e0y, cho th\u1ea5y quy tr\u00ecnh l\u00e0m vi\u1ec7c l\u00e2m s\u00e0ng \u0111\u01b0\u1ee3c c\u1ea3i thi\u1ec7n.<\/p>\n

C\u1ea3 Gi\u00e1o s\u01b0 Gibbs v\u00e0 Gi\u00e1o s\u01b0 Cherepanoff \u0111\u1ec1u h\u00e1o h\u1ee9c ch\u1edd \u0111\u1ee3i c\u00e1c c\u00f4ng c\u1ee5 ho\u1eb7c thu\u1eadt to\u00e1n ph\u00e2n t\u00edch k\u1ef9 thu\u1eadt s\u1ed1 \u0111\u01b0\u1ee3c h\u1ed7 tr\u1ee3 b\u1edfi AI (Artificial Intelligence, tri\u0301 tu\u00ea\u0323 nh\u00e2n ta\u0323o), c\u00f3 kh\u1ea3 n\u0103ng x\u1eed l\u00fd d\u1eef li\u1ec7u b\u1ed9 gen \u0111\u1ed9t bi\u1ebfn ph\u1ee9c t\u1ea1p v\u00e0 t\u00edch h\u1ee3p ch\u00fang v\u00e0o c\u00e1c h\u01b0\u1edbng d\u1eabn \u0111i\u1ec1u tr\u1ecb, t\u00e0i li\u1ec7u v\u00e0 th\u1eed nghi\u1ec7m. H\u1ecd c\u0169ng k\u1ef3 v\u1ecdng r\u1eb1ng c\u00e1c c\u00f4ng c\u1ee5 k\u1ef9 thu\u1eadt s\u1ed1 s\u1ebd ng\u00e0y c\u00e0ng k\u1ebft n\u1ed1i c\u00e1c b\u00e1c s\u0129 l\u00e2m s\u00e0ng \u00edt kinh nghi\u1ec7m h\u01a1n v\u1edbi c\u00e1c thu\u1eadt to\u00e1n ph\u00e2n lo\u1ea1i, gi\u00e1m s\u00e1t, chuy\u1ec3n tuy\u1ebfn ho\u1eb7c th\u1eed nghi\u1ec7m. Theo th\u1eddi gian, nhi\u1ec1u kh\u1ea3 n\u0103ng c\u00e1c c\u00f4ng c\u1ee5 n\u00e0y s\u1ebd \u0111\u01b0\u1ee3c tri\u1ec3n khai tr\u00ean n\u1ec1n t\u1ea3ng \u0111\u00e1m m\u00e2y, v\u00e0 c\u00e1c n\u1ec1n t\u1ea3ng qu\u1ea3n l\u00fd th\u00f4ng tin y t\u1ebf cu\u1ed1i c\u00f9ng s\u1ebd d\u1ef1a tr\u00ean \u1ee9ng d\u1ee5ng v\u00e0 \u0111\u0103ng k\u00fd.<\/p>\n

M\u1ed9t s\u1ed1 n\u0103ng l\u1ef1c v\u00e0 d\u1ecbch v\u1ee5 n\u00e0y \u0111\u00e3 c\u00f3 s\u1eb5n, nh\u01b0ng c\u00e1c b\u00e1c s\u0129 l\u00e2m s\u00e0ng v\u1eabn c\u00f2n ch\u1eadm ch\u1ea1p trong vi\u1ec7c \u00e1p d\u1ee5ng. “T\u00f4i th\u1ea5y kho\u1ea3ng c\u00e1ch gi\u1eefa nh\u1eefng g\u00ec c\u00f3 th\u1ec3 v\u00e0 nh\u1eefng g\u00ec \u0111ang \u0111\u01b0\u1ee3c cung c\u1ea5p”, Gi\u00e1o s\u01b0 Gibbs n\u00f3i. “Kho\u1ea3ng c\u00e1ch n\u00e0y \u0111ang ng\u00e0y c\u00e0ng l\u1edbn v\u00e0 \u0111i\u1ec1u \u0111\u00f3 khi\u1ebfn t\u00f4i lo ng\u1ea1i. T\u00f4i \u0111ang nghi\u00ean c\u1ee9u nhi\u1ec1u c\u00e1ch kh\u00e1c nhau \u0111\u1ec3 hi\u1ec3u t\u1ea7m quan tr\u1ecdng c\u1ee7a c\u00e1c d\u1ea5u \u1ea5n sinh h\u1ecdc, v\u00e0 \u0111\u00f3 ch\u1eafc ch\u1eafn l\u00e0 m\u1ed9t nhu c\u1ea7u c\u1ea5p thi\u1ebft.”<\/p>\n

\u0110\u1ec3 t\u00ecm hi\u1ec3u th\u00eam v\u1ec1 vai tr\u00f2 ng\u00e0y c\u00e0ng ph\u00e1t tri\u1ec3n c\u1ee7a gi\u1ea3i tr\u00ecnh t\u1ef1 th\u1ebf h\u1ec7 ti\u1ebfp theo, b\u1ea3ng kh\u1ed1i u ph\u00e2n t\u1eed v\u00e0 c\u00e1c c\u00f4ng c\u1ee5 h\u1ed7 tr\u1ee3 quy\u1ebft \u0111\u1ecbnh l\u00e2m s\u00e0ng trong ch\u0103m s\u00f3c ung th\u01b0, h\u00e3y xem m\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u \u0111i\u1ec3n h\u00ecnh kh\u00e1c sau \u0111\u00e2y:\u00a0<\/em><\/p>\n