{"id":147371,"date":"2021-08-06T06:05:16","date_gmt":"2021-08-06T06:05:16","guid":{"rendered":"https:\/\/labinsights.com\/acf_article\/nhung-dau-an-sinh-hoc-csf-dich-nao-tuy-va-vai-tro-cua-chung-trong-viec-quan-ly-benh-alzheimer\/"},"modified":"2026-01-27T07:26:07","modified_gmt":"2026-01-27T07:26:07","slug":"csf-biomarkers-and-their-role-in-alzheimers-disease-management","status":"publish","type":"acf_article","link":"https:\/\/labinsights.com\/vi\/operations\/immunoassay\/csf-biomarkers-and-their-role-in-alzheimers-disease-management\/","title":{"rendered":"Nh\u01b0\u0303ng d\u00e2\u0301u \u1ea5n sinh h\u1ecdc CSF (Di\u0323ch na\u0303o tu\u0309y) v\u00e0 vai tr\u00f2 c\u1ee7a ch\u00fang trong vi\u1ec7c qu\u1ea3n l\u00fd b\u1ec7nh Alzheimer"},"content":{"rendered":"

Trong b\u1ed1i c\u1ea3nh d\u00e2n s\u1ed1 th\u1ebf gi\u1edbi ti\u00ea\u0301p tu\u0323c gia\u0300 ho\u0301a, b\u1ec7nh Alzheimer l\u00e0 m\u1ed9t m\u00f4\u0301i lo nga\u0323i nghi\u00eam tro\u0323ng va\u0300 t\u0103ng l\u00ean nhanh cho\u0301ng trong s\u01b0\u0301c kho\u0309e c\u00f4\u0323ng \u0111\u00f4\u0300ng. Ch\u1ec9 ri\u00eang khu v\u1ef1c Ch\u00e2u \u00c1 – Th\u00e1i B\u00ecnh D\u01b0\u01a1ng \u01b0\u1edbc t\u00ednh hi\u1ec7n c\u00f3 h\u01a1n 23 tri\u1ec7u ca m\u1eafc b\u1ec7nh v\u00e0 con s\u1ed1 n\u00e0y d\u1ef1 ki\u1ebfn s\u1ebd t\u0103ng l\u00ean h\u01a1n 70 tri\u1ec7u ca v\u00e0o n\u0103m 2050 [1]. M\u1eb7c d\u00f9 ph\u00e2\u0300n l\u01a1\u0301n s\u01b0\u0323 quan t\u00e2m \u0111ang da\u0300nh cho m\u1ed9t ph\u01b0\u01a1ng pha\u0301p \u0111i\u00ea\u0300u tri\u0323 can thi\u00ea\u0323p m\u01a1\u0301i v\u01b0\u0300a \u0111\u01b0\u1ee3c FDA ph\u00ea duy\u1ec7t g\u1ea7n \u0111\u00e2y, nh\u01b0ng ch\u1ea9n \u0111o\u00e1n d\u01b0\u0323a va\u0300o xe\u0301t nghi\u00ea\u0323m c\u00e2\u0323n l\u00e2m sa\u0300ng c\u0169ng s\u1ebd r\u1ea5t c\u1ea7n thi\u1ebft \u0111\u00ea\u0309 giu\u0301p ki\u00ea\u0309m soa\u0301t cu\u1ed9c kh\u1ee7ng ho\u1ea3ng \u0111ang gia t\u0103ng n\u00e0y.<\/p>\n

D\u1ea5u \u1ea5n sinh h\u1ecdc CSF l\u00e0 g\u00ec?<\/h3>\n

Nhi\u1ec1u nghi\u00ean c\u1ee9u \u0111\u00e3 cho th\u1ea5y gi\u00e1 tr\u1ecb c\u1ee7a 3 d\u1ea5u \u1ea5n sinh h\u1ecdc l\u00f5i trong d\u1ecbch n\u00e3o t\u1ee7y (CSF) \u2014\u03b2-amyloid 42 (\u03b1\u03b242), t\u1ed5ng tau (T-tau) v\u00e0 tau phosphoryl h\u00f3a (P-tau)\u2014 trong qu\u00e1 tr\u00ecnh ch\u1ea9n \u0111o\u00e1n b\u1ec7nh Alzheimer. N\u1ed3ng \u0111\u1ed9 \u03b1\u03b242 \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n \u1edf n\u1ed3ng \u0111\u1ed9 th\u1ea5p h\u01a1n trong CSF v\u00e0 s\u1ef1 thay \u0111\u1ed5i n\u00e0y c\u00f3 th\u1ec3 th\u1ea5y \u00edt nh\u1ea5t 5 n\u0103m tr\u01b0\u1edbc khi b\u1ec7nh Alzheimer \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n ch\u00ednh th\u1ee9c [2]. T-tau v\u00e0 P-tau, c\u1ea3 hai d\u1ea5u \u00e2\u0301n th\u00ea\u0309 hi\u00ea\u0323n s\u1ef1 m\u1ea5t t\u1ebf b\u00e0o th\u1ea7n kinh, lu\u00f4n \u0111o \u0111\u01b0\u01a1\u0323c \u01a1\u0309 m\u01b0\u0301c cao h\u01a1n so v\u01a1\u0301i n\u00f4\u0300ng \u0111\u00f4\u0323 chu\u00e2\u0309n [3].<\/p>\n

CSF (Di\u0323ch na\u0303o tu\u0309y) c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c l\u00e2\u0301y nh\u01a1\u0300 k\u1ef9\u0303 thu\u00e2\u0323t cho\u0323c do\u0300 tu\u0309y s\u00f4\u0301ng th\u0103\u0301t l\u01b0ng v\u00e0 th\u00e0nh ph\u1ea7n trong di\u0323ch na\u0303o tu\u0309y \u0111\u01b0\u1ee3c coi la\u0300 s\u01b0\u0323 ph\u1ea3n \u00e1nh tr\u1ef1c ti\u1ebfp m\u00f4i tr\u01b0\u1eddng c\u1ee7a n\u00e3o. M\u1eb7c d\u00f9 v\u1eady, d\u1ea5u \u1ea5n sinh h\u1ecdc trong CSF (Di\u0323ch na\u0303o tu\u0309y) v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c \u01b0\u0301ng du\u0323ng r\u1ed9ng r\u00e3i trong ch\u1ea9n \u0111o\u00e1n l\u00e2m s\u00e0ng. Cho \u0111\u1ebfn nay, ch\u01b0a c\u00f3 s\u1ef1 \u0111\u1ed3ng thu\u1eadn ch\u00ednh th\u1ee9c v\u1edbi b\u1ea5t k\u1ef3 m\u1ee9c \u0111\u1ed9 ng\u01b0\u1ee1ng n\u00e0o cho nh\u01b0\u0303ng d\u00e2\u0301u \u00e2\u0301n sinh ho\u0323c trong di\u0323ch na\u0303o tu\u0309y \u0111\u01b0\u01a1\u0323c c\u00f4ng b\u00f4\u0301, nh\u01b0ng ca\u0301c nha\u0300 khoa ho\u0323c \u0111ang c\u00f3 r\u00e2\u0301t nhi\u00ea\u0300u n\u1ed7 l\u1ef1c r\u1ea5t l\u1edbn \u0111\u1ec3 chu\u1ea9n h\u00f3a c\u00e1c gi\u00e1 tr\u1ecb n\u00e0y.<\/p>\n

V\u1edbi s\u1ef1 thay \u0111\u1ed5i trong m\u1ed9t s\u1ed1 h\u01b0\u1edbng d\u1eabn l\u00e2m s\u00e0ng, ch\u1eb3ng h\u1ea1n nh\u01b0 theo ca\u0301ch h\u01b0\u01a1\u0301ng d\u00e2\u0303n \u0111\u00e1nh gi\u00e1 c\u1ee7a Vi\u1ec7n L\u00e3o khoa v\u00e0 Hi\u1ec7p h\u1ed9i Alzheimer Qu\u1ed1c gia (NIA-AA), vi\u00ea\u0323c ch\u1ea9n \u0111o\u00e1n b\u1ec7nh Alzheimer hi\u1ec7n nay c\u00f3 th\u1ec3 d\u1ef1a tr\u00ean c\u01a1 s\u1edf sinh h\u1ecdc, b\u00e2\u0301t k\u00ea\u0309 s\u01b0\u0323 xu\u00e2\u0301t hi\u00ea\u0323n v\u00e0 m\u1ee9c \u0111\u1ed9 nghi\u00eam tr\u1ecdng c\u1ee7a c\u00e1c tri\u1ec7u ch\u1ee9ng [4], c\u0169ng nh\u01b0 theo ch\u01b0\u01a1ng tr\u00ecnh ngoa\u0323i ki\u00ea\u0309m c\u1ee7a Hi\u1ec7p h\u1ed9i Alzheimer [5], hi\u1ec7n c\u00f3 th\u1ec3 co\u0301 nhi\u00ea\u0300u c\u01a1 h\u00f4\u0323i s\u01b0\u0309 du\u0323ng c\u00e1c d\u1ea5u \u1ea5n sinh h\u1ecdc trong CSF (Di\u0323ch na\u0303o tu\u0309y) trong \u0111a\u0301nh gia\u0301 m\u00f4i tr\u01b0\u1eddng l\u00e2m s\u00e0ng h\u01a1n tr\u01b0\u01a1\u0301c. N\u1ebfu \u0111\u01b0\u1ee3c ch\u00e2\u0301p thu\u00e2\u0323n, vi\u1ec7c s\u1eed d\u1ee5ng c\u00e1c d\u1ea5u \u1ea5n sinh h\u1ecdc trong CSF (Di\u0323ch na\u0303o tu\u0309y) c\u0169ng c\u00f3 th\u1ec3 \u0111\u01b0\u01a1\u0323c t\u0103ng c\u01b0\u01a1\u0300ng nh\u01a1\u0300 t\u1ef1 \u0111\u1ed9ng h\u00f3a, gi\u1ea3m thi\u00ea\u0309u thao ta\u0301c x\u1eed l\u00fd v\u00e0 l\u1ed7i do con ng\u01b0\u1eddi.<\/p>\n

L\u1ee3i \u00edch c\u1ee7a ch\u1ea9n \u0111o\u00e1n k\u1ecbp th\u1eddi<\/h3>\n

B\u1ec7nh Alzheimer h\u1ea7u nh\u01b0 lu\u00f4n b\u1eaft \u0111\u1ea7u v\u1edbi nh\u1eefng tri\u1ec7u ch\u1ee9ng nh\u1ecf v\u00e0 d\u00ea\u0303 bi\u0323 bo\u0309 qua nh\u01b0 nh\u1eefng kho\u1ea3nh kh\u1eafc hay qu\u00ean, m\u1ed9t tri\u00ea\u0323u ch\u01b0\u0301ng d\u00ea\u0303 g\u0103\u0323p khi tu\u1ed5i t\u00e1c t\u0103ng l\u00ean. T\u1ea1i th\u1eddi \u0111i\u1ec3m n\u00e0y, b\u1ec7nh nh\u00e2n c\u00f3 kh\u1ea3 n\u0103ng b\u1ecb suy gi\u1ea3m nh\u1eadn th\u1ee9c ch\u1ee7 quan; ca\u0301c da\u0323ng ch\u1ee9c n\u0103ng nh\u1eadn th\u1ee9c c\u00f3 th\u1ec3 b\u1ecb suy gi\u1ea3m nh\u01b0ng \u0111i\u1ec1u n\u00e0y kh\u00f4ng th\u1ec3 \u0111\u01b0\u1ee3c x\u00e1c \u0111i\u0323nh ch\u1ec9 d\u01b0\u0323a va\u0300o c\u00e1c \u0111\u00e1nh gi\u00e1 l\u00e2m s\u00e0ng.<\/p>\n

Giai \u0111o\u1ea1n xu\u00e2\u0301t hi\u00ea\u0323n ti\u00ea\u0301p sau \u0111o\u0301 l\u00e0 s\u01b0\u0323 suy gi\u1ea3m nh\u1eadn th\u1ee9c nh\u1eb9 (MCI), theo \u0111\u00f3 c\u00f3 th\u1ec3 th\u1ea5y b\u1eb1ng ch\u1ee9ng l\u00e2m s\u00e0ng th\u00f4ng qua h\u00ecnh \u1ea3nh ho\u0323c h\u00ea\u0323 th\u1ea7n kinh. V\u00ec MCI (s\u01b0\u0323 suy gia\u0309m nh\u00e2\u0323n th\u01b0\u0301c nhe\u0323) c\u0169ng xu\u00e2\u0301t hi\u00ea\u0323n trong c\u00e1c r\u1ed1i lo\u1ea1n tho\u00e1i h\u00f3a th\u1ea7n kinh kh\u00e1c, n\u00ean c\u00e1c d\u1ea5u \u1ea5n sinh h\u1ecdc trong CSF (di\u0323ch na\u0303o tu\u0309y) gi\u00fap ch\u1ea9n \u0111o\u00e1n ph\u00e2n bi\u1ec7t. Do c\u00f3 kho\u1ea3ng th\u1eddi gian t\u01b0\u0300 khi xu\u00e2\u0301t hi\u00ea\u0323n nh\u1eefng thay \u0111\u1ed5i v\u1ec1 sinh l\u00fd cho t\u01a1\u0301i khi xu\u00e2\u0301t hi\u00ea\u0323n c\u00e1c tri\u1ec7u ch\u1ee9ng l\u00e2m s\u00e0ng v\u00e0 bi\u00ea\u0301t r\u0103\u0300ng MCI (s\u01b0\u0323 suy gia\u0309m nh\u00e2\u0323n th\u01b0\u0301c nhe\u0323) l\u00e0 y\u1ebfu t\u1ed1 nguy c\u01a1 c\u1ee7a b\u1ec7nh Alzheimer, vi\u1ec7c s\u1eed d\u1ee5ng c\u00e1c d\u1ea5u \u1ea5n sinh h\u1ecdc trong CSF (di\u0323ch na\u0303o tu\u0309y) \u0111\u1ec3 ch\u1ea9n \u0111o\u00e1n k\u1ecbp th\u1eddi c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn tr\u1ea3i nghi\u1ec7m c\u1ee7a b\u1ec7nh nh\u00e2n m\u0103\u0301c b\u1ec7nh Alzheimer.<\/p>\n

Tr\u01b0\u1edbc khi c\u00f3 d\u1ea5u \u1ea5n sinh h\u1ecdc trong CSF (di\u0323ch na\u0303o tu\u0309y), ch\u1ea9n \u0111o\u00e1n b\u1ec7nh Alzheimer d\u1ef1a v\u00e0o h\u00ecnh \u1ea3nh ho\u0323c h\u00ea\u0323 th\u1ea7n kinh nh\u01b0 ch\u1ee5p PET (Chu\u0323p pha\u0301t xa\u0323 Positron) \u0111\u00ea\u0309 pha\u0301t hi\u00ea\u0323n ma\u0309ng protein amyloid trong n\u00e3o, m\u1ed9t d\u1ea5u hi\u1ec7u c\u1ee7a b\u1ec7nh Alzheimer. Tuy nhi\u00ean, ph\u01b0\u01a1ng ph\u00e1p n\u00e0y c\u0169ng c\u00f3 nh\u1eefng h\u1ea1n ch\u1ebf, t\u1eeb vi\u1ec7c ch\u1ea9n \u0111o\u00e1n mu\u1ed9n \u0111\u1ebfn vi\u1ec7c kh\u00f4ng co\u0301 kha\u0309 n\u0103ng ti\u1ebfp c\u1eadn \u0111\u01b0\u01a1\u0323c v\u1edbi thi\u1ebft b\u1ecb v\u00e0 chuy\u00ean gia. \u0110i\u1ec1u n\u00e0y c\u00f3 th\u1ec3 gi\u1ea3i th\u00edch t\u1ea1i sao 50 – 70% b\u1ec7nh nh\u00e2n th\u1eadm ch\u00ed kh\u00f4ng nh\u1eadn \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n xa\u0301c \u0111i\u0323nh.<\/p>\n

Ch\u1ea9n \u0111o\u00e1n k\u1ecbp th\u1eddi c\u00f3 th\u1ec3 cho ph\u00e9p ph\u00e1t hi\u1ec7n ch\u00ednh x\u00e1c b\u1ec7nh Alzheimer [6] v\u00e0 \u00e1p d\u1ee5ng c\u00e1c ph\u01b0\u01a1ng ph\u00e1p can thi\u1ec7p ho\u1eb7c ti\u00ea\u0301n ha\u0300nh c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng [7]. B\u00ean ngo\u00e0i ph\u00f2ng kh\u00e1m, b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c cung c\u1ea5p \u0111\u1ea7y \u0111\u1ee7 th\u00f4ng tin v\u00e0 c\u00f3 th\u1ec3 t\u1ef1 quy\u1ebft \u0111\u1ecbnh v\u1ec1 t\u01b0\u01a1ng lai c\u1ee7a m\u00ecnh, t\u1eeb vi\u1ec7c quy\u1ebft \u0111\u1ecbnh c\u00e1c l\u1ef1a ch\u1ecdn s\u1ed1ng trong t\u01b0\u01a1ng lai cho \u0111\u1ebfn vi\u1ec7c th\u1ef1c hi\u1ec7n c\u00e1c th\u1ecfa thu\u1eadn ph\u00e1p l\u00fd ph\u00f9 h\u1ee3p. Ch\u1ea9n \u0111o\u00e1n k\u1ecbp th\u1eddi c\u0169ng c\u00f3 th\u1ec3 gi\u00fap h\u1ec7 th\u1ed1ng ch\u0103m s\u00f3c s\u1ee9c kh\u1ecfe c\u1ee7a m\u1ed9t qu\u1ed1c gia \u0111\u1ecbnh h\u00ecnh ch\u00ednh s\u00e1ch c\u1ee7a h\u1ecd trong nhi\u1ec1u th\u1eadp k\u1ef7 t\u1edbi. <\/p>\n

Ti\u1ec1m n\u0103ng s\u1eed d\u1ee5ng nh\u01b0 ch\u1ea9n \u0111o\u00e1n ph\u00f4\u0301i h\u01a1\u0323p<\/h3>\n

Ca\u0301c d\u1ea5u \u1ea5n sinh h\u1ecdc trong CSF (di\u0323ch na\u0303o tu\u0309y) \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng cho ca\u0301c li\u00ea\u0323u pha\u0301p ki\u00ea\u0309m soa\u0301t b\u1ec7nh (DMT) nh\u1eb1m can thi\u1ec7p v\u00e0o qu\u00e1 tr\u00ecnh ti\u1ebfn tri\u1ec3n l\u00e2m s\u00e0ng c\u1ee7a b\u1ec7nh Alzheimer [8]. \u0110\u1ec3 ph\u00e2n t\u1ea7ng ph\u00f9 h\u1ee3p nh\u1eefng b\u1ec7nh nh\u00e2n \u0111\u1ee7 \u0111i\u1ec1u ki\u1ec7n tham gia th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng, ki\u00ea\u0309m tra c\u00e1c d\u1ea5u \u1ea5n sinh h\u1ecdc trong CSF (d\u1ecbch n\u00e3o t\u1ee7y) (v\u00e0 ch\u1ee5p PET, chu\u0323p pha\u0301t xa\u0323 Positron) \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n nh\u01b0 nh\u01b0\u0303ng x\u00e9t nghi\u1ec7m xa\u0301c \u0111i\u0323nh s\u1ef1 xu\u00e2\u0301t hi\u1ec7n nh\u1eefng thay \u0111\u1ed5i v\u1ec1 m\u1eb7t sinh l\u00fd.<\/p>\n

V\u1edbi s\u1ed1 l\u01b0\u1ee3ng x\u00e9t nghi\u1ec7m d\u00e2\u0301u \u00e2\u0301n sinh h\u1ecdc ng\u00e0y c\u00e0ng t\u0103ng v\u00e0 ti\u1ebfn b\u1ed9 trong qua\u0301 tri\u0300nh chu\u1ea9n h\u00f3a, c\u00e1c d\u00e2\u0301u \u00e2\u0301n sinh h\u1ecdc trong CSF (di\u0323ch na\u0303o tu\u0309y) c\u00f3 th\u1ec3 h\u1ed7 tr\u1ee3 tr\u00ean nhi\u00ea\u0300u ph\u01b0\u01a1ng di\u00ea\u0323n cho c\u00e1c c\u1ed9t m\u1ed1c quan tr\u1ecdng trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng. Nh\u01b0\u1ee3c \u0111i\u1ec3m c\u00f3 th\u1ec3 co\u0301 l\u00e0 b\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3 kh\u00f4ng chi\u0323u \u0111\u01b0\u1ee3c vi\u00ea\u0323c bi\u0323 ch\u1ecdc d\u1ecbch t\u1ee7y s\u1ed1ng nhi\u00ea\u0300u l\u00e2\u0300n, \u0111i\u1ec1u n\u00e0y th\u00fac \u0111\u1ea9y nhu c\u1ea7u nghi\u00ean c\u1ee9u s\u00e2u h\u01a1n v\u1ec1 vi\u1ec7c ph\u00e1t tri\u1ec3n c\u00e1c d\u1ea5u \u1ea5n sinh h\u1ecdc trong m\u00e1u nh\u01b0 m\u1ed9t gi\u1ea3i ph\u00e1p thay th\u1ebf.<\/p>\n

Nhi\u1ec1u nghi\u00ean c\u1ee9u \u0111\u00e3 n\u00eau ra nh\u1eefng l\u1ee3i \u00edch ti\u1ec1m n\u0103ng c\u1ee7a vi\u1ec7c ch\u1ea9n \u0111o\u00e1n k\u1ecbp th\u1eddi, bao g\u1ed3m nh\u01b0\u0303ng c\u01a1 h\u1ed9i \u0111i\u1ec1u tr\u1ecb s\u1edbm h\u01a1n ho\u1eb7c can thi\u1ec7p s\u1edbm h\u01a1n v\u01a1\u0301i DMTs (nh\u01b0\u0303ng li\u00ea\u0323u pha\u0301p ki\u00ea\u0309m soa\u0301t b\u00ea\u0323nh). V\u1edbi m\u1ed9t t\u00e1c nh\u00e2n d\u01b0\u1ee3c l\u00fd tr\u00ean th\u1ecb tr\u01b0\u1eddng, l\u1ee3i \u00edch v\u00ea\u0300 m\u0103\u0323t l\u00fd thuy\u1ebft n\u00e0y hi\u00ea\u0323n nay c\u00f3 c\u01a1 h\u1ed9i tr\u1edf th\u00e0nh hi\u1ec7n th\u1ef1c. S\u1ef1 ra \u0111\u1eddi c\u1ee7a m\u1ed9t lo\u1ea1i thu\u1ed1c m\u1edbi c\u00f3 th\u1ec3 giu\u0301p nhi\u1ec1u b\u00e1c s\u0129 l\u00e2m sa\u0300ng \u01b0\u0301ng d\u1ee5ng c\u00e1c d\u1ea5u \u1ea5n sinh h\u1ecdc \u0111\u1ec3 ch\u1ea9n \u0111o\u00e1n chi\u0301nh xa\u0301c b\u1ec7nh Alzheimer cho b\u1ec7nh nh\u00e2n c\u1ee7a h\u1ecd.T\u00e0i li\u1ec7u tham kh\u1ea3o<\/p>\n

<\/em><\/p>\n

[1]<\/a> Sa s\u00fat tr\u00ed tu\u1ec7 \u1edf khu v\u1ef1c Ch\u00e2u \u00c1 Th\u00e1i B\u00ecnh D\u01b0\u01a1ng 2014 B\u00e1o c\u00e1o, B\u1ec7nh Alzheimer Qu\u1ed1c t\u1ebf<\/p>\n

[2]<\/a>\u00a0Buchhave, P. et al. (2012) N\u1ed3ng \u0111\u1ed9 \u03b2-Amyloid 1-42 trong d\u1ecbch n\u00e3o t\u1ee7y, nh\u01b0ng kh\u00f4ng ph\u1ea3i c\u1ee7a n\u00f4\u0300ng \u0111\u00f4\u0323 Tau, \u0111\u00e3 ho\u00e0n to\u00e0n thay \u0111\u1ed5i trong vo\u0300ng t\u01b0\u0300 5 \u0111\u1ebfn 10 n\u0103m tr\u01b0\u1edbc khi kh\u1edfi ph\u00e1t sa s\u00fat tr\u00ed tu\u1ec7 Alzheimer.L\u01b0u tr\u1eef t\u00e2m th\u1ea7n h\u1ecdc chung <\/i>, 69 (1), pp98.<\/p>\n

[3]<\/a>\u00a0Olsson, B., et al. (2016) CSF (di\u0323ch na\u0303o tu\u0309y) v\u00e0 c\u00e1c d\u1ea5u \u1ea5n sinh h\u1ecdc trong m\u00e1u giu\u0301p ch\u1ea9n \u0111o\u00e1n b\u1ec7nh Alzheimer: m\u1ed9t nghi\u00ean c\u01b0\u0301u t\u1ed5ng quan h\u1ec7 th\u1ed1ng v\u00e0 ph\u00e2n t\u00edch t\u1ed5ng h\u1ee3p. The Lancet Neurology<\/em>, 15, pp673-684.<\/p>\n

[4]<\/a>\u00a0H\u01b0\u1edbng d\u1eabn ch\u1ea9n \u0111o\u00e1n b\u1ec7nh Alzheimer, Ngu\u1ed3n th\u00f4ng tin nghi\u00ean c\u01b0\u0301u v\u00ea\u0300 sa s\u00fat tr\u00ed tu\u1ec7 cho c\u00e1c chuy\u00ean gia y t\u1ebf, Vi\u1ec7n S\u01b0\u0301c kho\u0309e Qu\u1ed1c gia<\/p>\n

[5]<\/a>\u00a0Ch\u01b0\u01a1ng tr\u00ecnh ki\u00ea\u0309m soa\u0301t ch\u00e2\u0301t l\u01b0\u01a1\u0323ng (QC, Quality Control) c\u1ee7a Hi\u1ec7p h\u1ed9i Alzheimer d\u00e0nh cho c\u00e1c d\u1ea5u \u1ea5n sinh h\u1ecdc trong d\u1ecbch n\u00e3o t\u1ee7y v\u00e0 m\u00e1u<\/p>\n

[6]<\/a> Dubois, B. et al. (2016) Ch\u1ea9n \u0111o\u00e1n k\u1ecbp th\u1eddi b\u1ec7nh Alzheimer: M\u00f4\u0323t nghi\u00ean c\u01b0\u0301u nhi\u0300n la\u0323i y v\u0103n v\u1ec1 l\u1ee3i \u00edch v\u00e0 nh\u01b0\u0303ng th\u00e1ch th\u1ee9c g\u0103\u0323p pha\u0309i. T\u1ea1p ch\u00ed b\u1ec7nh<\/em>Alzheimer, 49, pp617-631.<\/p>\n

[7]<\/a>\u00a0Lleo, A. et al. (2014) D\u1ea5u \u1ea5n sinh h\u1ecdc trong d\u1ecbch n\u00e3o t\u1ee7y \u01a1\u0309 c\u00e1c th\u1eed nghi\u1ec7m da\u0300nh cho b\u1ec7nh Alzheimer v\u00e0 Parkinson. Nature Reviews Th\u1ea7n kinh h\u1ecdc<\/em>, 11, trang41-55.<\/p>\n

[8]<\/a>\u00a0Horgan, D. et al. (2020) X\u00e9t nghi\u1ec7m d\u1ea5u \u1ea5n sinh h\u1ecdc: Ve\u0301n ma\u0300n s\u01b0\u01a1ng che phu\u0309 b\u1ec7nh Alzheimer v\u00e0 ch\u1ee9ng m\u1ea5t tr\u00ed li\u00ean quan. Trung t\u00e2m Biomedicine<\/p>\n","protected":false},"excerpt":{"rendered":"

Trong b\u1ed1i c\u1ea3nh d\u00e2n s\u1ed1 th\u1ebf gi\u1edbi ti\u00ea\u0301p tu\u0323c gia\u0300 ho\u0301a, b\u1ec7nh Alzheimer l\u00e0 m\u1ed9t m\u00f4\u0301i lo nga\u0323i nghi\u00eam tro\u0323ng va\u0300 t\u0103ng l\u00ean nhanh cho\u0301ng trong s\u01b0\u0301c kho\u0309e c\u00f4\u0323ng \u0111\u00f4\u0300ng. Ch\u1ec9 ri\u00eang khu v\u1ef1c Ch\u00e2u \u00c1 – Th\u00e1i B\u00ecnh D\u01b0\u01a1ng \u01b0\u1edbc t\u00ednh hi\u1ec7n c\u00f3 h\u01a1n 23 tri\u1ec7u ca m\u1eafc b\u1ec7nh v\u00e0 con s\u1ed1 n\u00e0y d\u1ef1 […]<\/p>\n","protected":false},"author":1,"featured_media":85256,"parent":0,"menu_order":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"tags":[14754,14843],"pillarandcategory":[317,309],"reporter":[14943],"class_list":["post-147371","acf_article","type-acf_article","status-publish","has-post-thumbnail","hentry","tag-gia-tri-lam-sang","tag-xet-nghiem-mien-dich","pillarandcategory-immunoassay","pillarandcategory-operations","reporter-samantha-yeoh"],"acf":[],"_links":{"self":[{"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/acf_article\/147371","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/acf_article"}],"about":[{"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/types\/acf_article"}],"author":[{"embeddable":true,"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":1,"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/acf_article\/147371\/revisions"}],"predecessor-version":[{"id":147598,"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/acf_article\/147371\/revisions\/147598"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/media\/85256"}],"wp:attachment":[{"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/media?parent=147371"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/tags?post=147371"},{"taxonomy":"pillarandcategory","embeddable":true,"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/pillarandcategory?post=147371"},{"taxonomy":"reporter","embeddable":true,"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/reporter?post=147371"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}