{"id":149761,"date":"2026-01-27T08:25:31","date_gmt":"2026-01-27T08:25:31","guid":{"rendered":"https:\/\/labinsights.com\/acf_article\/dinh-lieu-ky-thuat-so-va-tuong-lai-cua-giam-sat-nong-do-thuoc-trong-dieu-tri-nhung-goc-nhin-tu-hoi-nghi-quoc-te-iatdmct-lan-thu-23\/"},"modified":"2026-03-09T10:00:10","modified_gmt":"2026-03-09T10:00:10","slug":"digital-dosing-and-the-future-of-therapeutic-drug-monitoring-insights-from-the-23rd-iatdmct-congress","status":"publish","type":"acf_article","link":"https:\/\/labinsights.com\/vi\/event-coverage\/conferences\/digital-dosing-and-the-future-of-therapeutic-drug-monitoring-insights-from-the-23rd-iatdmct-congress\/","title":{"rendered":"\u0110\u1ecbnh li\u1ec1u k\u1ef9 thu\u1eadt s\u1ed1 v\u00e0 t\u01b0\u01a1ng lai c\u1ee7a gi\u00e1m s\u00e1t n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong \u0111i\u1ec1u tr\u1ecb: Nh\u1eefng g\u00f3c nh\u00ecn t\u1eeb H\u1ed9i ngh\u1ecb qu\u1ed1c t\u1ebf IATDMCT l\u1ea7n th\u1ee9 23"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Khi \u0111\u1ec1 c\u1eadp \u0111\u1ebfn \u0111i\u1ec1u tr\u1ecb, th\u00e1ch th\u1ee9c l\u00e2m s\u00e0ng c\u1ed1t l\u00f5i th\u01b0\u1eddng \u0111\u01b0\u1ee3c g\u00f3i g\u1ecdn trong m\u1ed9t c\u00e2u h\u1ecfi mang t\u00ednh quy\u1ebft \u0111\u1ecbnh: <\/span><i><span style=\"font-weight: 400;\">li\u1ec1u l\u01b0\u1ee3ng thu\u1ed1c bao nhi\u00eau l\u00e0 \u0111\u1ee7, v\u00e0 th\u1eddi gian \u0111i\u1ec1u tr\u1ecb n\u00ean k\u00e9o d\u00e0i bao l\u00e2u?<\/span><\/i><span style=\"font-weight: 400;\"> Trong su\u1ed1t m\u1ed9t th\u1eddi gian d\u00e0i, kh\u00e1t v\u1ecdng h\u01b0\u1edbng t\u1edbi y h\u1ecdc c\u00e1 th\u1ec3 h\u00f3a th\u1ef1c th\u1ee5 \u0111\u00e3 b\u1ecb k\u00ecm h\u00e3m b\u1edfi nh\u1eefng h\u1ea1n ch\u1ebf c\u1ee7a ph\u01b0\u01a1ng ph\u00e1p \u0111\u1ecbnh li\u1ec1u t\u0129nh, r\u1eadp khu\u00f4n (&#8216;m\u1ed9t k\u00edch c\u1ee1 cho t\u1ea5t c\u1ea3&#8217;) v\u00e0 c\u00e1c m\u00f4 h\u00ecnh d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc (PK) l\u1ed7i th\u1eddi \u2013 m\u1ed9t h\u1ec7 th\u1ed1ng c\u1ee9ng nh\u1eafc kh\u00f4ng \u0111\u1ee7 kh\u1ea3 n\u0103ng \u0111\u00e1p \u1ee9ng cho c\u00e1c lo\u1ea1i thu\u1ed1c ti\u00ean ti\u1ebfn nh\u01b0 li\u1ec7u ph\u00e1p sinh h\u1ecdc hay c\u00e1c h\u1ee3p ch\u1ea5t m\u1edbi c\u00f3 ho\u1ea1t t\u00ednh m\u1ea1nh.\u00a0<\/span> <span style=\"font-weight: 400;\">Nh\u01b0ng \u0111i\u1ec1u g\u00ec s\u1ebd x\u1ea3y ra n\u1ebfu nh\u1eefng c\u00f4ng c\u1ee5 k\u1ef9 thu\u1eadt s\u1ed1 chuy\u1ec3n \u0111\u1ed5i ng\u00e0nh c\u00f4ng nghi\u1ec7p c\u1ee7a ch\u00fang ta c\u00f3 th\u1ec3 cho b\u1ea1n th\u00eam th\u1eddi gian?<\/span> <span style=\"font-weight: 400;\">S\u1ef1 t\u00edch h\u1ee3p c\u00e1c c\u00f4ng ngh\u1ec7 k\u1ef9 thu\u1eadt s\u1ed1 hi\u1ec7n \u0111\u1ea1i c\u00f3 th\u1ec3 thay \u0111\u1ed5i c\u0103n b\u1ea3n c\u1ee5c di\u1ec7n n\u00e0y, chuy\u1ec3n \u0111\u1ed5i gi\u00e1m s\u00e1t n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong \u0111i\u1ec1u tr\u1ecb (TDM) t\u1eeb m\u1ed9t c\u00f4ng c\u1ee5 \u0111o l\u01b0\u1eddng mang t\u00ednh \u0111\u1ed1i ph\u00f3 th\u00e0nh m\u1ed9t chi\u1ebfn l\u01b0\u1ee3c l\u00e2m s\u00e0ng ch\u1ee7 \u0111\u1ed9ng v\u00e0 c\u00f3 t\u00ednh d\u1ef1 b\u00e1o. Chuy\u1ec3n \u0111\u1ed5i k\u1ef9 thu\u1eadt s\u1ed1 n\u00e0y cung c\u1ea5p cho c\u00e1c b\u00e1c s\u0129 l\u00e2m s\u00e0ng kh\u1ea3 n\u0103ng ra quy\u1ebft \u0111\u1ecbnh hi\u1ec7u qu\u1ea3, ch\u00ednh x\u00e1c, \u0111\u1ed3ng th\u1eddi cho ph\u00e9p c\u00e1c ph\u00f2ng x\u00e9t nghi\u1ec7m v\u00e0 b\u1ec7nh vi\u1ec7n \u0111\u1ea1t \u0111\u01b0\u1ee3c k\u1ebft qu\u1ea3 t\u1ed1t h\u01a1n, gi\u1ea3m chi ph\u00ed v\u00e0 c\u1ea3i thi\u1ec7n tr\u1ea3i nghi\u1ec7m c\u1ee7a b\u1ec7nh nh\u00e2n [1, 2].<\/span> <span style=\"font-weight: 400;\">T\u00ednh kh\u1ea3 thi c\u1ee7a t\u1ea7m nh\u00ecn n\u00e0y l\u00e0 m\u1ed9t trong nh\u1eefng ch\u1ee7 \u0111\u1ec1 tr\u1ecdng t\u00e2m t\u1ea1i h\u1ed9i ngh\u1ecb qu\u1ed1c t\u1ebf l\u1ea7n th\u1ee9 23 c\u1ee7a Hi\u1ec7p h\u1ed9i gi\u00e1m s\u00e1t thu\u1ed1c \u0111i\u1ec1u tr\u1ecb v\u00e0 \u0111\u1ed9c h\u1ecdc l\u00e2m s\u00e0ng (IATDMCT) t\u1ea1i Singapore n\u0103m ngo\u00e1i. Di\u1ec5n ra v\u00e0o th\u00e1ng 9 v\u1eeba qua, s\u1ef1 ki\u1ec7n \u0111\u00e3 quy t\u1ee5 m\u1ed9t \u0111\u1ed9i ng\u0169 tinh hoa g\u1ed3m c\u00e1c chuy\u00ean gia h\u00e0ng \u0111\u1ea7u v\u00e0 nh\u1eefng ng\u01b0\u1eddi ti\u00ean phong v\u1ec1 chi\u1ebfn l\u01b0\u1ee3c trong ng\u00e0nh \u0111\u1ec3 tr\u00ecnh di\u1ec5n ch\u00ednh x\u00e1c c\u00e1ch th\u1ee9c v\u1eadn h\u00e0nh c\u00e1c c\u00f4ng c\u1ee5 n\u00e0y trong th\u1ef1c ti\u1ec5n.\u00a0<\/span> <span style=\"font-weight: 400;\">Nh\u00f3m Lab Insights \u0111\u00e3 ghi nh\u1eadn nh\u1eefng th\u00f4ng tin chuy\u00ean s\u00e2u quan tr\u1ecdng, r\u00fat ra t\u1eeb b\u1ed1n b\u00e0i tr\u00ecnh b\u00e0y chuy\u00ean s\u00e2u, ch\u1ee9ng minh ph\u01b0\u01a1ng ph\u00e1p ti\u1ebfp c\u1eadn nhi\u1ec1u m\u1eb7t \u0111\u1ec3 s\u1ed1 h\u00f3a TDM v\u00e0 \u0111\u1ed9c ch\u1ea5t h\u1ecdc l\u00e2m s\u00e0ng, x\u00e1c nh\u1eadn vai tr\u00f2 c\u1ee7a qu\u00e1 tr\u00ecnh s\u1ed1 h\u00f3a n\u00e0y trong ti\u1ebfn tr\u00ecnh h\u01b0\u1edbng t\u1edbi ch\u0103m s\u00f3c c\u00e1 nh\u00e2n h\u00f3a:\u00a0<\/span><\/p>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li><span style=\"font-weight: 400;\">B\u00e1c s\u0129 Amy Legg kh\u00e1m ph\u00e1 vai tr\u00f2 chi\u1ebfn l\u01b0\u1ee3c c\u1ee7a tr\u00ed tu\u1ec7 nh\u00e2n t\u1ea1o (AI) v\u00e0 Big Data trong vi\u1ec7c \u0111\u1ecbnh h\u00ecnh l\u1ea1i nghi\u00ean c\u1ee9u TDM, nh\u1ea5n m\u1ea1nh s\u1ef1 c\u1ea7n thi\u1ebft c\u1ee7a c\u00e1c m\u00f4 h\u00ecnh d\u1ef1 \u0111o\u00e1n \u0111\u1ed9ng. C\u00f4ng vi\u1ec7c c\u1ee7a b\u00e0 \u2013 b\u1eaft ngu\u1ed3n t\u1eeb d\u01b0\u1ee3c l\u00e2m s\u00e0ng v\u00e0 qu\u1ea3n l\u00fd s\u1eed d\u1ee5ng kh\u00e1ng sinh, \u0111\u00e3 l\u00e0m n\u1ed5i b\u1eadt ti\u1ec1m n\u0103ng c\u1ee7a vi\u1ec7c l\u1ed3ng gh\u00e9p nghi\u00ean c\u1ee9u v\u00e0o h\u1ec7 th\u1ed1ng h\u1ed3 s\u01a1 s\u1ee9c kh\u1ecfe \u0111i\u1ec7n t\u1eed (EHR) \u0111\u1ec3 gi\u1ea3i quy\u1ebft c\u00e1c v\u1ea5n \u0111\u1ec1 l\u00e2m s\u00e0ng ph\u1ee9c t\u1ea1p, t\u1eeb nh\u1eefng t\u01b0\u01a1ng t\u00e1c thu\u1ed1c hi\u1ebfm g\u1eb7p cho \u0111\u1ebfn d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc (PK) \u0111\u1eb7c th\u00f9 tr\u00ean t\u1eebng qu\u1ea7n th\u1ec3 b\u1ec7nh nh\u00e2n.<\/span><\/li>\n<\/ul>\n<\/li>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">B\u00e1c s\u0129 Tomoyuki Yamada \u0111\u00e3 gi\u1edbi thi\u1ec7u c\u00e1ch vi\u1ec7c khai th\u00e1c c\u00e1c ngu\u1ed3n d\u1eef li\u1ec7u th\u1ef1c t\u1ebf (RWD) kh\u1ed5ng l\u1ed3 cung c\u1ea5p t\u00edn hi\u1ec7u an to\u00e0n quan tr\u1ecdng v\u00e0 th\u00fac \u0111\u1ea9y c\u00e1c th\u1ef1c h\u00e0nh l\u00e2m s\u00e0ng v\u1ec1 \u0111\u1ed9c ch\u1ea5t h\u1ecdc v\u00e0 theo d\u00f5i thu\u1ed1c. V\u1edbi vai tr\u00f2 l\u00e0 D\u01b0\u1ee3c s\u0129 tr\u01b0\u1edfng d\u1eabn d\u1eaft c\u00e1c n\u1ed7 l\u1ef1c c\u1ea3nh gi\u00e1c d\u01b0\u1ee3c, c\u00e1c nghi\u00ean c\u1ee9u \u0111i\u1ec3n h\u00ecnh c\u1ee7a B\u00e1c s\u0129 Yamada \u2013 ch\u1eb3ng h\u1ea1n nh\u01b0 \u0111\u00e1nh gi\u00e1 t\u01b0\u01a1ng t\u00e1c gi\u1eefa daptomycin v\u00e0 statin, hay ph\u00e2n t\u00edch hi\u1ec7u qu\u1ea3 c\u1ee7a vi\u1ec7c gi\u00e1m s\u00e1t n\u1ed3ng \u0111\u1ed9 thu\u1ed1c (TDM) ti\u1ebfp n\u1ed1i nh\u1eb1m gi\u1ea3m \u0111\u1ed9c t\u00ednh c\u1ee7a vancomycin \u2013 \u0111\u00e3 minh ch\u1ee9ng cho nh\u1eefng t\u00e1c \u0111\u1ed9ng h\u1eefu h\u00ecnh c\u1ee7a ph\u00e2n t\u00edch d\u1eef li\u1ec7u th\u1ef1c t\u1ebf (RWD) \u0111\u1ed1i v\u1edbi k\u1ebft qu\u1ea3 \u0111i\u1ec1u tr\u1ecb c\u1ee7a b\u1ec7nh nh\u00e2n.<\/span><\/li>\n<\/ul>\n<\/li>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">B\u00e1c s\u0129 Dirk Jan Moes \u0111\u00e3 tr\u00ecnh b\u00e0y chi ti\u1ebft v\u1ec1 vi\u1ec7c \u1ee9ng d\u1ee5ng chi\u1ebfn l\u01b0\u1ee3c c\u1ee7a Ph\u01b0\u01a1ng ph\u00e1p \u0111\u1ecbnh li\u1ec1u ch\u00ednh x\u00e1c d\u1ef1a tr\u00ean m\u00f4 h\u00ecnh (MIPD) \u0111\u1ed1i v\u1edbi c\u00e1c lo\u1ea1i thu\u1ed1c sinh h\u1ecdc ph\u1ee9c t\u1ea1p trong ung th\u01b0 h\u1ecdc, \u0111\u1ed3ng th\u1eddi nh\u1ea5n m\u1ea1nh nh\u1eefng l\u1ee3i \u00edch r\u00f5 r\u1ec7t v\u1ec1 m\u1eb7t l\u00e2m s\u00e0ng v\u00e0 t\u00e0i ch\u00ednh m\u00e0 c\u00e1c h\u1ec7 th\u1ed1ng k\u1ef9 thu\u1eadt s\u1ed1 t\u00edch h\u1ee3p mang l\u1ea1i. L\u00e0 ph\u00f3 gi\u00e1o s\u01b0 d\u01b0\u1ee3c l\u00fd l\u00e2m s\u00e0ng, B\u00e1c s\u0129 Moes t\u1eadp trung v\u00e0o c\u00e1ch c\u00e1c chi\u1ebfn l\u01b0\u1ee3c MIPD c\u00f3 th\u1ec3 c\u00e1 nh\u00e2n h\u00f3a vi\u1ec7c \u0111\u1ecbnh li\u1ec1u cho c\u00e1c sinh ph\u1ea9m c\u1ee5 th\u1ec3 &#8211; bao g\u1ed3m Daratumab v\u00e0 Nivolumab &#8211; \u0111\u1ec3 gi\u1ea3m c\u1ea3 \u0111\u1ed9c t\u00ednh t\u00e0i ch\u00ednh v\u00e0 l\u00e2m s\u00e0ng.<\/span><\/li>\n<\/ul>\n<\/li>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">B\u00e1c s\u0129 Tomoyuki Mizuno \u0111\u00e3 m\u00f4 t\u1ea3 c\u00e1ch s\u1eed d\u1ee5ng c\u00e1c c\u00f4ng ngh\u1ec7 ti\u00ean ti\u1ebfn nh\u01b0 h\u1ecdc m\u00e1y (ML) v\u00e0 c\u00e1c b\u1ea3ng \u0111i\u1ec1u khi\u1ec3n \u0111\u1ec3 h\u1ed7 tr\u1ee3 ra quy\u1ebft \u0111\u1ecbnh t\u00edch h\u1ee3p \u0111\u1ec3 th\u00fac \u0111\u1ea9y \u0111\u1ecbnh li\u1ec1u si\u00eau ch\u00ednh x\u00e1c, \u0111\u1eb7c bi\u1ec7t l\u00e0 trong m\u00f4i tr\u01b0\u1eddng ch\u0103m s\u00f3c b\u1ec7nh nh\u00e2n nhi \u0111\u1ea7y th\u00e1ch th\u1ee9c. Bs. Mizuno, ng\u01b0\u1eddi ch\u1ec9 \u0111\u1ea1o Trung t\u00e2m \u01afu t\u00fa v\u1ec1 D\u01b0\u1ee3c l\u01b0\u1ee3ng h\u1ecdc, \u0111\u00e3 t\u1eadp trung v\u00e0o vi\u1ec7c n\u00e2ng c\u1ea5p khung m\u00f4 h\u00ecnh MIPD b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng h\u1ecdc m\u00e1y \u0111\u1ec3 gi\u1ea3i quy\u1ebft nh\u1eefng ph\u1ee9c t\u1ea1p \u0111\u1eb7c th\u00f9 trong vi\u1ec7c \u0111\u1ecbnh li\u1ec1u cho tr\u1ebb em, t\u1eeb \u0111\u00f3 cung c\u1ea5p cho c\u00e1c b\u00e1c s\u0129 l\u00e2m s\u00e0ng nh\u1eefng c\u00f4ng c\u1ee5 s\u00e1ng t\u1ea1o ngay t\u1ea1i gi\u01b0\u1eddng b\u1ec7nh.<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">C\u00f9ng nhau, c\u00e1c chuy\u00ean gia \u0111\u00e3 l\u00e0m s\u00e1ng t\u1ecf nh\u1eefng tr\u1ee5 c\u1ed9t k\u1ef9 thu\u1eadt s\u1ed1 thi\u1ebft y\u1ebfu \u2013 nh\u1eefng nh\u00e2n t\u1ed1 s\u1ebd \u0111\u1ecbnh h\u00ecnh th\u1ebf h\u1ec7 gi\u00e1 tr\u1ecb ch\u1ea9n \u0111o\u00e1n v\u00e0 ch\u0103m s\u00f3c b\u1ec7nh nh\u00e2n ti\u1ebfp theo.<\/span><\/p>\n<h2 style=\"font-family: Inter !important; font-weight: 500 !important; font-size: 28px !important; line-height: 36px !important; letter-spacing: 0px !important;\">Ph\u01b0\u01a1ng ph\u00e1p \u0111\u1ecbnh li\u1ec1u ch\u00ednh x\u00e1c d\u1ef1a tr\u00ean m\u00f4 h\u00ecnh (MIPD) l\u00e0m n\u1ec1n t\u1ea3ng c\u01a1 b\u1ea3n<\/h2>\n<p><span style=\"font-weight: 400;\">Kh\u00f4ng c\u00f3 hai c\u01a1 th\u1ec3 n\u00e0o ho\u00e0n to\u00e0n gi\u1ed1ng h\u1ec7t nhau, v\u00e0 lu\u00f4n t\u1ed3n t\u1ea1i m\u1ed9t nhu c\u1ea7u l\u00e2m s\u00e0ng \u0111\u1ed1i v\u1edbi vi\u1ec7c c\u00e1 nh\u00e2n h\u00f3a \u0111i\u1ec1u tr\u1ecb. &#8220;C\u01a1 th\u1ec3 ch\u00fang ta kh\u00f4ng gi\u1ed1ng nh\u01b0 m\u1ed9t b\u1ec3 c\u00e1 \u0111\u1ed3ng nh\u1ea5t. Thu\u1ed1c \u0111\u01b0\u1ee3c ph\u00e2n b\u1ed5 theo nh\u1eefng c\u00e1ch ho\u00e0n to\u00e0n kh\u00e1c nhau,&#8221; Gi\u00e1o s\u01b0 Andrea Kwa t\u1eeb B\u1ec7nh vi\u1ec7n \u0110a khoa Singapore \u0111\u00e3 nh\u1ea5n m\u1ea1nh trong b\u00e0i ph\u00e1t bi\u1ec3u ch\u00ednh c\u1ee7a m\u00ecnh. M\u1ee5c ti\u00eau c\u1ee7a \u0111\u1ecbnh li\u1ec1u ch\u00ednh x\u00e1c l\u00e0 x\u00e1c \u0111\u1ecbnh ph\u00e1c \u0111\u1ed3 li\u1ec1u l\u01b0\u1ee3ng t\u1ed1i \u01b0u nh\u1ea5t v\u00e0 ph\u00e1c \u0111\u1ed3 \u0111\u00f3 s\u1ebd cung c\u1ea5p hi\u1ec7u qu\u1ea3 c\u1ea7n thi\u1ebft v\u1edbi m\u1ee9c \u0111\u1ed9c t\u00ednh t\u1ed1i thi\u1ec3u cho t\u1eebng b\u1ec7nh nh\u00e2n [1]. MIPD \u0111\u00e3 n\u1ed5i l\u00ean nh\u01b0 m\u1ed9t khu\u00f4n kh\u1ed5 \u0111\u1ecbnh l\u01b0\u1ee3ng thi\u1ebft y\u1ebfu \u0111\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c m\u1ee5c ti\u00eau n\u00e0y. Ph\u01b0\u01a1ng ph\u00e1p n\u00e0y s\u1eed d\u1ee5ng c\u00e1c m\u00f4 h\u00ecnh d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc\/d\u01b0\u1ee3c l\u1ef1c h\u1ecdc (PK\/PD) tinh vi \u0111\u1ec3 t\u00edch h\u1ee3p v\u00e0 s\u1eed d\u1ee5ng th\u00f4ng tin c\u1ee5 th\u1ec3 c\u1ee7a b\u1ec7nh nh\u00e2n v\u00e0 c\u00e1c quan s\u00e1t l\u00e2m s\u00e0ng, c\u00e1 nh\u00e2n h\u00f3a li\u1ec1u l\u01b0\u1ee3ng \u1edf nhi\u1ec1u b\u01b0\u1edbc trong su\u1ed1t qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb b\u1eb1ng thu\u1ed1c.<\/span> <span style=\"font-weight: 400;\">Ph\u01b0\u01a1ng ph\u00e1p n\u00e0y c\u00f3 ch\u1ee9c n\u0103ng nh\u01b0 m\u1ed9t chu k\u1ef3 d\u1ef1 \u0111o\u00e1n, x\u00e1c nh\u1eadn, h\u1ecdc h\u1ecfi v\u00e0 \u00e1p d\u1ee5ng:<\/span><\/p>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>D\u1ef1 \u0111o\u00e1n (\u0111i\u1ec1u ch\u1ec9nh li\u1ec1u tr\u01b0\u1edbc):<\/b><span style=\"font-weight: 400;\"> D\u1eef li\u1ec7u b\u1ec7nh nh\u00e2n t\u1ea1i th\u1eddi \u0111i\u1ec3m n\u1ec1n t\u1ea3ng &#8211; ch\u1eb3ng h\u1ea1n nh\u01b0 tr\u1ecdng l\u01b0\u1ee3ng, tu\u1ed5i, \u0111\u1eb7c \u0111i\u1ec3m di truy\u1ec1n v\u00e0 ch\u1ee9c n\u0103ng c\u01a1 quan &#8211; \u0111\u01b0\u1ee3c thu th\u1eadp d\u01b0\u1edbi d\u1ea1ng \u0111\u1ed3ng bi\u1ebfn \u0111\u1ec3 th\u00f4ng b\u00e1o cho m\u00f4 h\u00ecnh v\u00e0 thi\u1ebft k\u1ebf li\u1ec1u kh\u1edfi \u0111\u1ea7u ban \u0111\u1ea7u. B\u00e1c s\u0129 Moes g\u1ecdi b\u01b0\u1edbc \u0111\u1ea7u ti\u00ean quan tr\u1ecdng n\u00e0y l\u00e0 &#8220;th\u00edch \u1ee9ng li\u1ec1u l\u01b0\u1ee3ng tr\u01b0\u1edbc&#8221; [2].<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>X\u00e1c nh\u1eadn v\u00e0 s\u00e0ng l\u1ecdc:<\/b><span style=\"font-weight: 400;\"> \u0110\u1ec3 ki\u1ec3m so\u00e1t s\u1ef1 bi\u1ebfn thi\u00ean cao gi\u1eefa c\u00e1c b\u1ec7nh nh\u00e2n, d\u1eef li\u1ec7u quan s\u00e1t \u0111\u01b0\u1ee3c (v\u00ed d\u1ee5: \u0111o n\u1ed3ng \u0111\u1ed9 thu\u1ed1c v\u00e0 d\u1ea5u \u1ea5n sinh h\u1ecdc PD) \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng l\u00e0m ph\u1ea3n h\u1ed3i Bayes \u0111\u1ec3 c\u1eadp nh\u1eadt m\u00f4 h\u00ecnh, cho ph\u00e9p m\u00f4 h\u00ecnh ph\u1ea3n \u00e1nh vi\u1ec7c x\u1eed l\u00fd v\u00e0 ki\u1ec3u h\u00ecnh thu\u1ed1c th\u1ef1c t\u1ebf c\u1ee7a b\u1ec7nh nh\u00e2n. [2] Qu\u00e1 tr\u00ecnh l\u1eb7p l\u1ea1i n\u00e0y cho ph\u00e9p thu th\u1eadp d\u1ea5u \u1ea5n sinh h\u1ecdc sau khi tinh ch\u1ebf li\u1ec1u l\u01b0\u1ee3ng c\u1ea7n thi\u1ebft, \u0111i\u1ec1u n\u00e0y \u0111\u1eb7c bi\u1ec7t quan tr\u1ecdng khi qu\u1ea3n l\u00fd c\u00e1c lo\u1ea1i thu\u1ed1c ph\u1ee9c t\u1ea1p h\u01a1n nh\u01b0 sinh h\u1ecdc trong ung th\u01b0 m\u00e1u, trong \u0111\u00f3 B\u00e1c s\u0129 Moes nh\u1ea5n m\u1ea1nh t\u1ea7m quan tr\u1ecdng c\u1ee7a hi\u1ec7u qu\u1ea3 v\u00e0 \u0111\u1ed9 an to\u00e0n cho c\u00e1c qu\u1ea7n th\u1ec3 b\u1ec7nh nh\u00e2n \u0111\u1ea7y th\u00e1ch th\u1ee9c. [2]<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Do \u0111\u00f3, y\u1ebfu t\u1ed1 h\u1ed7 tr\u1ee3 ch\u00ednh cho vi\u1ec7c s\u1eed d\u1ee5ng hi\u1ec7u qu\u1ea3 MIPD \u0111\u00f2i h\u1ecfi c\u01a1 s\u1edf h\u1ea1 t\u1ea7ng l\u00e2m s\u00e0ng m\u1ea1nh m\u1ebd, c\u00e1c x\u00e9t nghi\u1ec7m trong ph\u00f2ng th\u00ed nghi\u1ec7m \u0111\u00e1ng tin c\u1eady (v\u00ed d\u1ee5: <\/span><span style=\"font-weight: 400;\">S\u1eafc k\u00fd l\u1ecfng-Kh\u1ed1i ph\u1ed5 \u0111\u1ec3 gh\u00e9p k\u00eanh nhi\u1ec1u kh\u00e1ng th\u1ec3) v\u00e0, quan tr\u1ecdng l\u00e0 t\u00edch h\u1ee3p EHR v\u00e0 h\u1ec7 th\u1ed1ng th\u00f4ng tin ph\u00f2ng th\u00ed nghi\u1ec7m (LIS) tr\u1ef1c ti\u1ebfp v\u00e0o c\u00f4ng c\u1ee5 \u0111\u1ecbnh li\u1ec1u [1]. M\u1ed9t v\u00ed d\u1ee5 \u0111i\u1ec3n h\u00ecnh cho v\u1ebf sau ch\u00ednh l\u00e0 ch\u01b0\u01a1ng tr\u00ecnh mang t\u00ean RoadMAB \u2013 m\u1ed9t ph\u1ea7n m\u1ec1m v\u1eadn h\u00e0nh \u0111\u1ecbnh li\u1ec1u \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n b\u1edfi B\u00e1c s\u0129 Mizuno v\u00e0 \u0111\u1ed9i ng\u0169 c\u1ee7a \u00f4ng t\u1ea1i Trung t\u00e2m Y t\u1ebf B\u1ec7nh vi\u1ec7n Nhi Cincinnati (CCHMC) [3, 4].<\/span> <span style=\"font-weight: 400;\">C\u00f4ng c\u1ee5 n\u00e0y \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf \u0111\u1eb7c bi\u1ec7t \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u00edch h\u1ee3p v\u00e0o c\u00e1c EHR \u0111\u1ec3 t\u1ef1 \u0111\u1ed9ng hi\u1ec7u ch\u1ec9nh d\u1eef li\u1ec7u b\u1ec7nh nh\u00e2n c\u1ea7n thi\u1ebft \u0111\u1ec3 ph\u00e2n t\u00edch, \u0111\u00f3ng hi\u1ec7u qu\u1ea3 v\u00f2ng l\u1eb7p k\u1ef9 thu\u1eadt s\u1ed1 gi\u1eefa d\u1eef li\u1ec7u, ch\u1ea9n \u0111o\u00e1n v\u00e0 quy\u1ebft \u0111\u1ecbnh.\u00a0\u00a0<\/span><\/p>\n<h2 style=\"font-family: Inter !important; font-weight: 500 !important; font-size: 28px !important; line-height: 36px !important; letter-spacing: 0px !important;\">S\u1ee9c m\u1ea1nh c\u1ee7a d\u1eef li\u1ec7u th\u1ef1c t\u1ebf (RWD) v\u00e0 ph\u00e2n t\u00edch d\u1eef li\u1ec7u l\u1edbn<\/h2>\n<p><span style=\"font-weight: 400;\">Trong khi MIPD cung c\u1ea5p khung \u0111\u1ecbnh l\u01b0\u1ee3ng quan tr\u1ecdng cho qu\u00e1 tr\u00ecnh \u0111\u1ecbnh li\u1ec1u c\u00e1 nh\u00e2n h\u00f3a, s\u1ee9c m\u1ea1nh th\u1ef1c s\u1ef1 c\u1ee7a ph\u01b0\u01a1ng ph\u00e1p k\u1ef9 thu\u1eadt s\u1ed1 n\u00e0y \u0111\u01b0\u1ee3c hi\u1ec7n th\u1ef1c h\u00f3a khi c\u00e1c m\u00f4 h\u00ecnh d\u1ef1 \u0111o\u00e1n c\u1ee7a n\u00f3 li\u00ean t\u1ee5c \u0111\u01b0\u1ee3c tinh ch\u1ec9nh b\u1edfi c\u00e1c b\u1eb1ng ch\u1ee9ng th\u1ef1c t\u1ebf. \u0110\u00e2y l\u00e0 l\u00fac RWD v\u00e0 ph\u00e2n t\u00edch d\u1eef li\u1ec7u l\u1edbn tr\u1edf th\u00e0nh c\u00f4ng c\u1ee5 kh\u00f4ng th\u1ec3 thi\u1ebfu \u0111\u1ec3 th\u00fac \u0111\u1ea9y c\u1ea3 TDM v\u00e0 nghi\u00ean c\u1ee9u \u0111\u1ed9c t\u00ednh l\u00e2m s\u00e0ng [5].\u00a0<\/span> <span style=\"font-weight: 400;\">S\u1ee9c m\u1ea1nh c\u1ee7a RWD n\u1eb1m \u1edf kh\u1ea3 n\u0103ng thu th\u1eadp tr\u00ean ph\u1ea1m vi r\u1ed9ng l\u1edbn. RWD c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb c\u00e1c c\u01a1 s\u1edf d\u1eef li\u1ec7u b\u00e1o c\u00e1o t\u1ef1 ph\u00e1t, d\u1eef li\u1ec7u y\u00eau c\u1ea7u b\u1ed3i th\u01b0\u1eddng b\u1ea3o hi\u1ec3m v\u00e0 h\u1ed3 s\u01a1 s\u1ee9c kh\u1ecfe \u0111i\u1ec7n t\u1eed (EHR), mang l\u1ea1i nh\u1eefng g\u00f3c nh\u00ecn b\u1ed5 tr\u1ee3 quan tr\u1ecdng cho vi\u1ec7c ph\u00e1t hi\u1ec7n c\u00e1c bi\u1ebfn c\u1ed1 b\u1ea5t l\u1ee3i v\u00e0 \u0111\u00e1nh gi\u00e1 c\u00e1c m\u00f4 h\u00ecnh th\u1ef1c h\u00e0nh l\u00e2m s\u00e0ng hi\u1ec7n t\u1ea1i [6]. T\u1eadp d\u1eef li\u1ec7u kh\u1ed5ng l\u1ed3 v\u00e0 ph\u1ee9c t\u1ea1p n\u00e0y l\u00e0 y\u1ebfu t\u1ed1 thi\u1ebft y\u1ebfu \u0111\u1ec3 thi\u1ebft l\u1eadp c\u00e1c gi\u1ea3 thuy\u1ebft nghi\u00ean c\u1ee9u: c\u00e1c t\u1eadp d\u1eef li\u1ec7u th\u1ef1c t\u1ebf quan s\u00e1t quy m\u00f4 l\u1edbn \u2013 ch\u1eb3ng h\u1ea1n nh\u01b0 h\u1ec7 th\u1ed1ng \u0111\u0103ng k\u00fd BLUeY v\u1ec1 gi\u00e1m s\u00e1t n\u1ed3ng \u0111\u1ed9 thu\u1ed1c (TDM) kh\u00e1ng sinh nh\u00f3m beta-lactam \u0111\u01b0\u1ee3c B\u00e1c s\u0129 Legg tr\u00edch d\u1eabn [5] \u2013 cho ph\u00e9p h\u1ecdc m\u00e1y nh\u1eadn di\u1ec7n s\u1edbm c\u00e1c t\u00edn hi\u1ec7u mang t\u00ednh g\u1ee3i m\u1edf gi\u1ea3 thuy\u1ebft. Nh\u1eefng t\u00edn hi\u1ec7u n\u00e0y th\u01b0\u1eddng b\u1ecb b\u1ecf l\u1ee1 trong c\u00e1c nghi\u00ean c\u1ee9u truy\u1ec1n th\u1ed1ng quy m\u00f4 nh\u1ecf do c\u00e1c k\u1ebft qu\u1ea3 hi\u1ebfm g\u1eb7p ho\u1eb7c s\u1ef1 bi\u1ebfn thi\u00ean ph\u1ee9c t\u1ea1p gi\u1eefa c\u00e1c b\u1ec7nh nh\u00e2n [8].\u00a0<\/span> <span style=\"font-weight: 400;\">Quan tr\u1ecdng h\u01a1n, d\u1eef li\u1ec7u n\u00e0y c\u00f3 kh\u1ea3 n\u0103ng chuy\u1ec3n tr\u1ef1c ti\u1ebfp sang t\u00e1c \u0111\u1ed9ng l\u00e2m s\u00e0ng c\u00f3 th\u1ec3 ch\u1ee9ng minh \u0111\u01b0\u1ee3c. Ph\u00e2n t\u00edch d\u1eef li\u1ec7u y\u00eau c\u1ea7u b\u1ed3i th\u01b0\u1eddng b\u1ea3o hi\u1ec3m, v\u00ed d\u1ee5, \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng TDM theo d\u00f5i ph\u00f9 h\u1ee3p c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m \u0111\u00e1ng k\u1ec3 t\u1ef7 l\u1ec7 \u0111\u1ed9c t\u00ednh do thu\u1ed1c g\u00e2y ra, v\u1edbi m\u1ed9t nghi\u00ean c\u1ee9u l\u01b0u \u00fd r\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p n\u00e0y l\u00e0m gi\u1ea3m t\u1ef7 l\u1ec7 nhi\u1ec5m \u0111\u1ed9c th\u1eadn do vancomycin g\u00e2y ra t\u1eeb 60,9% \u0111\u1ebfn 9,9%, nh\u01b0 \u0111\u01b0\u1ee3c chia s\u1ebb b\u1edfi B\u00e1c s\u0129 Yamada [6].\u00a0<\/span><\/p>\n<h2 style=\"font-family: Inter !important; font-weight: 500 !important; font-size: 28px !important; line-height: 36px !important; letter-spacing: 0px !important;\">AI v\u00e0 m\u00e1y h\u1ecdc (ML) h\u1ed7 tr\u1ee3 ra quy\u1ebft \u0111\u1ecbnh cho th\u1ebf h\u1ec7 ti\u1ebfp theo<\/h2>\n<p><span style=\"font-weight: 400;\">Kh\u1ea3 n\u0103ng t\u1ea1o ra c\u00e1c gi\u1ea3 thuy\u1ebft v\u00e0 x\u00e1c nh\u1eadn c\u00e1c m\u00f4 h\u00ecnh th\u1ef1c h\u00e0nh b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng RWD t\u1ea1o ra nhu c\u1ea7u s\u1ed1ng c\u00f2n cho c\u00e1c c\u00f4ng c\u1ee5 ph\u00e2n t\u00edch tinh vi c\u00f3 kh\u1ea3 n\u0103ng x\u1eed l\u00fd c\u00e1c b\u1ed9 d\u1eef li\u1ec7u l\u1edbn, ph\u1ee9c t\u1ea1p nh\u01b0 v\u1eady. Ch\u00ednh nh\u1edd s\u1ee9c m\u1ea1nh t\u00ednh to\u00e1n ti\u00ean ti\u1ebfn c\u1ee7a AI v\u00e0 ML, c\u00e1c ph\u00f2ng th\u00ed nghi\u1ec7m ch\u1ea9n \u0111o\u00e1n v\u00e0 c\u00e1c nh\u00f3m l\u00e2m s\u00e0ng c\u00f3 th\u1ec3 chuy\u1ec3n \u0111\u1ed5i l\u01b0\u1ee3ng d\u1eef li\u1ec7u kh\u1ed5ng l\u1ed3 n\u00e0y th\u00e0nh th\u00f4ng tin chuy\u00ean s\u00e2u v\u1ec1 li\u1ec1u l\u01b0\u1ee3ng d\u1ef1 \u0111o\u00e1n, c\u00f3 th\u1ec3 tri\u1ec3n khai v\u00e0 c\u00e1 nh\u00e2n h\u00f3a.<\/span><\/p>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>M\u00f4 h\u00ecnh \u0111\u1ed9ng:<\/b><span style=\"font-weight: 400;\"> AI \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c x\u1eed l\u00fd c\u00e1c k\u00edch th\u01b0\u1edbc m\u1eabu l\u1edbn v\u00e0 c\u00e1c bi\u1ebfn s\u1ed1 g\u00e2y nhi\u1ec5u c\u1ea7n thi\u1ebft \u0111\u1ec3 ph\u00e1t tri\u1ec3n c\u00e1c m\u00f4 h\u00ecnh PK (PopPK) qu\u1ea7n th\u1ec3 ph\u1ee9c t\u1ea1p v\u00e0 n\u0103ng \u0111\u1ed9ng h\u01a1n &#8211; nh\u1eefng m\u00f4 h\u00ecnh c\u00f3 th\u1ec3 \u0111i\u1ec1u ch\u1ec9nh theo c\u00e1c th\u00f4ng s\u1ed1 l\u00e2m s\u00e0ng thay \u0111\u1ed5i theo th\u1eddi gian c\u1ee7a b\u1ec7nh nh\u00e2n, nh\u01b0 \u0111\u01b0\u1ee3c B\u00e1c s\u0129 Legg nh\u1ea5n m\u1ea1nh [8].<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>M\u00f4 h\u00ecnh lai<\/b><span style=\"font-weight: 400;\">: B\u00e1c s\u0129 Mizuno c\u0169ng nh\u1ea5n m\u1ea1nh r\u1eb1ng nh\u1eefng ph\u01b0\u01a1ng ph\u00e1p h\u1ee9a h\u1eb9n nh\u1ea5t hi\u1ec7n nay l\u00e0 nh\u1eefng ph\u01b0\u01a1ng ph\u00e1p v\u01b0\u1ee3t xa kh\u1ecfi c\u00e1c c\u00f4ng ngh\u1ec7 \u0111\u01a1n l\u1ebb, r\u1eddi r\u1ea1c. M\u00f4 h\u00ecnh n\u00e0y bao g\u1ed3m k\u1ebft h\u1ee3p t\u00ednh kh\u1ea3 thi l\u00e2m s\u00e0ng c\u1ee7a \u01b0\u1edbc t\u00ednh Bayes th\u00f4ng th\u01b0\u1eddng v\u1edbi ML (v\u00ed d\u1ee5, s\u1eed d\u1ee5ng m\u00f4 h\u00ecnh XGBoost) \u0111\u1ec3 s\u1eeda l\u1ed7i d\u1ef1 \u0111o\u00e1n. Qu\u00e1 tr\u00ecnh n\u00e0y t\u1ea1o ra c\u00e1c m\u00f4 h\u00ecnh lai m\u1ea1nh m\u1ebd, lu\u00f4n v\u01b0\u1ee3t tr\u1ed9i h\u01a1n c\u00e1c ph\u01b0\u01a1ng ph\u00e1p PopPK th\u00f4ng th\u01b0\u1eddng [3].<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>T\u1ef1 \u0111\u1ed9ng h\u00f3a v\u00e0 t\u00e1c nh\u00e2n AI:<\/b><span style=\"font-weight: 400;\"> Nh\u00ecn v\u1ec1 ph\u00eda tr\u01b0\u1edbc, c\u00e1c h\u1ec7 th\u1ed1ng trong t\u01b0\u01a1ng lai \u0111ang s\u1eed d\u1ee5ng ph\u01b0\u01a1ng ph\u00e1p h\u1ecdc t\u0103ng c\u01b0\u1eddng \u0111\u1ec3 t\u1ea1o ra c\u00e1c t\u00e1c nh\u00e2n AI c\u00f3 th\u1ec3 t\u1ef1 \u0111\u1ed9ng thu th\u1eadp d\u1eef li\u1ec7u b\u1ec7nh nh\u00e2n, \u0111\u00e1nh gi\u00e1 c\u00e1c l\u1ef1a ch\u1ecdn \u0111i\u1ec1u tr\u1ecb v\u00e0 \u0111\u1ec1 xu\u1ea5t c\u00e1c ph\u00e1c \u0111\u1ed3 v\u00e0 kho\u1ea3ng th\u1eddi gian d\u00f9ng thu\u1ed1c. B\u00e1c s\u0129 Mizuno c\u0169ng \u0111\u00e3 nh\u1ea5n m\u1ea1nh r\u1eb1ng s\u1ef1 ti\u1ebfn b\u1ed9 n\u00e0y s\u1ebd \u0111\u01a1n gi\u1ea3n h\u00f3a to\u00e0n b\u1ed9 qu\u00e1 tr\u00ecnh d\u00f9ng thu\u1ed1c v\u00e0 c\u1ea3i thi\u1ec7n hi\u1ec7u qu\u1ea3 trong vi\u1ec7c ra quy\u1ebft \u0111\u1ecbnh c\u1ee7a con ng\u01b0\u1eddi [3].<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2 style=\"font-family: Inter !important; font-weight: 500 !important; font-size: 28px !important; line-height: 36px !important; letter-spacing: 0px !important;\">Gi\u00e1 tr\u1ecb chi\u1ebfn l\u01b0\u1ee3c v\u00e0 l\u1ee3i t\u1ee9c \u0111\u1ea7u t\u01b0 (ROI) cho l\u00e3nh \u0111\u1ea1o ch\u1ea9n \u0111o\u00e1n<\/h2>\n<p><span style=\"font-weight: 400;\">Nh\u00ecn chung, vi\u1ec7c t\u00edch h\u1ee3p c\u00e1c khung MIPD, RWD v\u00e0 AI d\u1ef1 b\u00e1o kh\u00f4ng ch\u1ec9 l\u00e0 m\u1ed9t kh\u00e1i ni\u1ec7m h\u1ecdc thu\u1eadt; n\u00f3 \u0111\u1ea1i di\u1ec7n cho m\u1ed9t s\u1ef1 thay \u0111\u1ed5i c\u01a1 b\u1ea3n trong vi\u1ec7c x\u00e1c nh\u1eadn gi\u00e1 tr\u1ecb c\u1ee7a ch\u1ea9n \u0111o\u00e1n. \u0110\u1ed1i v\u1edbi l\u00e3nh \u0111\u1ea1o ph\u00f2ng x\u00e9t nghi\u1ec7m v\u00e0 b\u1ec7nh vi\u1ec7n, s\u1ef1 h\u1ed9i t\u1ee5 n\u00e0y chuy\u1ec3n tr\u1ef1c ti\u1ebfp th\u00e0nh c\u00e1c l\u1ee3i \u00edch \u0111\u1ecbnh l\u01b0\u1ee3ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn c\u1ea3 l\u1ee3i \u00edch t\u00e0i ch\u00ednh c\u1ee7a b\u1ec7nh nh\u00e2n v\u00e0 c\u1ee7a t\u1ed5 ch\u1ee9c. <\/span><\/p>\n<h3 style=\"font-family: Inter !important; font-weight: 500 !important; font-size: 24px !important; line-height: 32px !important; letter-spacing: 0px !important;\">A) N\u00e2ng cao \u0111\u1ed9 an to\u00e0n v\u00e0 k\u1ebft qu\u1ea3 l\u00e2m s\u00e0ng cho b\u1ec7nh nh\u00e2n<\/h3>\n<p><span style=\"font-weight: 400;\">L\u1ee3i \u00edch ch\u00ednh c\u1ee7a chuy\u1ec3n \u0111\u1ed5i k\u1ef9 thu\u1eadt s\u1ed1 l\u00e0 n\u00e2ng cao c\u00e1c d\u1ecbch v\u1ee5 ch\u1ea9n \u0111o\u00e1n t\u1eeb b\u00e1o c\u00e1o th\u1ee5 \u0111\u1ed9ng \u0111\u1ebfn h\u01b0\u1edbng d\u1eabn c\u00e1 nh\u00e2n h\u00f3a, ch\u1ee7 \u0111\u1ed9ng, t\u1eeb \u0111\u00f3 ch\u0103m s\u00f3c b\u1ec7nh nh\u00e2n t\u1ed1t h\u01a1n:<\/span><\/p>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u0110\u1ed9 ch\u00ednh x\u00e1c v\u00e0 chu\u1ea9n x\u00e1c:<\/b><span style=\"font-weight: 400;\"> Thu\u1eadt to\u00e1n AI mang l\u1ea1i kh\u1ea3 n\u0103ng d\u1ef1 b\u00e1o \u1edf m\u1ee9c \u0111\u1ed9 m\u00e0 tr\u01b0\u1edbc \u0111\u00e2y ch\u01b0a t\u1eebng \u0111\u1ea1t \u0111\u01b0\u1ee3c. V\u00ed d\u1ee5, c\u00e1c c\u00f4ng c\u1ee5 AI \u0111\u00e3 ch\u1ee9ng minh kh\u1ea3 n\u0103ng d\u1ef1 b\u00e1o c\u00e1c gi\u00e1 tr\u1ecb l\u00e2m s\u00e0ng ch\u00ednh, ch\u1eb3ng h\u1ea1n nh\u01b0 t\u1ef7 s\u1ed1 chu\u1ea9n h\u00f3a qu\u1ed1c t\u1ebf (INR) v\u00e0o ng\u00e0y th\u1ee9 n\u0103m khi s\u1eed d\u1ee5ng warfarin, v\u1edbi \u0111\u1ed9 ch\u00ednh x\u00e1c c\u00f3 th\u1ec3 t\u01b0\u01a1ng \u0111\u01b0\u01a1ng ho\u1eb7c th\u1eadm ch\u00ed v\u01b0\u1ee3t tr\u1ed9i h\u01a1n so v\u1edbi c\u00e1c chuy\u00ean gia y t\u1ebf [8]. Kh\u1ea3 n\u0103ng d\u1ef1 b\u00e1o n\u00e0y gi\u00fap gi\u1ea3m thi\u1ec3u s\u1ef1 ch\u1eadm tr\u1ec5 nguy hi\u1ec3m trong \u0111i\u1ec1u tr\u1ecb t\u1ed1i \u01b0u.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Can thi\u1ec7p ch\u1ee7 \u0111\u1ed9ng:<\/b><span style=\"font-weight: 400;\"> B\u1eb1ng c\u00e1ch li\u00ean k\u1ebft c\u00e1c m\u00f4 h\u00ecnh d\u1ef1 \u0111o\u00e1n v\u1edbi quy tr\u00ecnh l\u00e0m vi\u1ec7c l\u00e2m s\u00e0ng, c\u00e1c b\u1ea3ng \u0111i\u1ec1u khi\u1ec3n h\u1ed7 tr\u1ee3 quy\u1ebft \u0111\u1ecbnh k\u1ef9 thu\u1eadt s\u1ed1 cho ph\u00e9p c\u00e1c b\u00e1c s\u0129 l\u00e2m s\u00e0ng nh\u1eadn \u0111\u01b0\u1ee3c khuy\u1ebfn ngh\u1ecb li\u1ec1u ngay l\u1eadp t\u1ee9c c\u00f3 h\u01b0\u1edbng d\u1eabn b\u1edfi PK. Theo B\u00e1c s\u0129 Mizuno, vi\u1ec7c n\u00e0y t\u1ea1o \u0111i\u1ec1u ki\u1ec7n thu\u1eadn l\u1ee3i cho vi\u1ec7c can thi\u1ec7p ch\u1ee7 \u0111\u1ed9ng, h\u1ed7 tr\u1ee3 k\u1ebft qu\u1ea3 \u0111i\u1ec1u tr\u1ecb t\u1ed1t h\u01a1n b\u1eb1ng c\u00e1ch \u0111\u1ea3m b\u1ea3o b\u1ec7nh nh\u00e2n \u0111\u1ea1t \u0111\u01b0\u1ee3c v\u00e0 duy tr\u00ec c\u00e1c m\u1ee5c ti\u00eau \u0111i\u1ec1u tr\u1ecb nhanh h\u01a1n, do \u0111\u00f3 gi\u1ea3m t\u1ef7 l\u1ec7 m\u1eafc b\u1ec7nh v\u00e0 \u1edf l\u1ea1i b\u1ec7nh vi\u1ec7n [3].\u00a0<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h3 style=\"font-family: Inter !important; font-weight: 500 !important; font-size: 24px !important; line-height: 32px !important; letter-spacing: 0px !important;\">B) Hi\u1ec7u qu\u1ea3 ho\u1ea1t \u0111\u1ed9ng v\u00e0 gi\u1ea3m \u0111\u1ed9c t\u00ednh t\u00e0i ch\u00ednh<\/h3>\n<p><span style=\"font-weight: 400;\">Digital TDM ho\u1ea1t \u0111\u1ed9ng nh\u01b0 m\u1ed9t \u0111\u00f2n b\u1ea9y m\u1ea1nh m\u1ebd \u0111\u1ec3 ki\u1ec3m so\u00e1t chi ph\u00ed, \u0111\u1eb7c bi\u1ec7t li\u00ean quan \u0111\u1ebfn c\u00e1c lo\u1ea1i thu\u1ed1c \u0111\u1eb7c bi\u1ec7t \u0111\u1eaft ti\u1ec1n, bi\u1ebfn gi\u00e1m s\u00e1t thu\u1ed1c th\u00e0nh ngu\u1ed3n l\u1ee3i nhu\u1eadn t\u00e0i ch\u00ednh h\u1eefu h\u00ecnh:<\/span><\/p>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Ki\u1ec3m so\u00e1t chi ph\u00ed:<\/b><span style=\"font-weight: 400;\"> Vi\u1ec7c t\u1ed1i \u01b0u h\u00f3a \u0111\u1ecbnh li\u1ec1u tr\u1ef1c ti\u1ebfp gi\u1ea3i quy\u1ebft v\u1ea5n \u0111\u1ec1 chi ph\u00ed cao c\u1ee7a c\u00e1c li\u1ec7u ph\u00e1p \u0111\u1eaft ti\u1ec1n b\u1eb1ng c\u00e1ch gi\u1ea3m thi\u1ec3u s\u1ef1 l\u00e3ng ph\u00ed thu\u1ed1c v\u00e0 m\u1ee9c \u0111\u1ed9 ti\u1ebfp x\u00fac thu\u1ed1c kh\u00f4ng c\u1ea7n thi\u1ebft. B\u1eb1ng c\u00e1ch \u0111\u1ea3m b\u1ea3o m\u1ecdi li\u1ec1u l\u01b0\u1ee3ng l\u00e0 ch\u00ednh x\u00e1c nh\u1ea5t c\u00f3 th\u1ec3, c\u00e1c b\u1ec7nh vi\u1ec7n c\u00f3 th\u1ec3 gi\u1ea3m thi\u1ec3u \u0111\u00e1ng k\u1ec3 th\u00e1ch th\u1ee9c ng\u00e0y c\u00e0ng t\u0103ng v\u1ec1 \u0111\u1ed9c t\u00ednh t\u00e0i ch\u00ednh li\u00ean quan \u0111\u1ebfn c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ti\u00ean ti\u1ebfn [2].<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>ROI c\u00f3 th\u1ec3 \u0111\u1ecbnh l\u01b0\u1ee3ng \u0111\u01b0\u1ee3c:<\/b><span style=\"font-weight: 400;\"> Vi\u1ec7c s\u1eed d\u1ee5ng chi\u1ebfn l\u01b0\u1ee3c c\u00e1c m\u00f4 h\u00ecnh PK\/PD v\u00e0 \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u l\u01b0\u1ee3ng <\/span><i><span style=\"font-weight: 400;\">gi\u1ea3 l\u1eadp<\/span><\/i><span style=\"font-weight: 400;\"> \u0111\u00e3 mang l\u1ea1i hi\u1ec7u qu\u1ea3 ti\u1ebft ki\u1ec7m chi ph\u00ed \u0111\u00e1ng k\u1ec3 v\u00e0 c\u00f3 th\u1ec3 \u0111o l\u01b0\u1eddng \u0111\u01b0\u1ee3c:<\/span>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><b>Gi\u1ea3m thi\u1ec3u l\u00e3ng ph\u00ed thu\u1ed1c:<\/b><span style=\"font-weight: 400;\"> Trong vi\u1ec7c \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u l\u01b0\u1ee3ng cho m\u1ed9t s\u1ed1 lo\u1ea1i thu\u1ed1c li\u00ean h\u1ee3p kh\u00e1ng th\u1ec3 &#8211; thu\u1ed1c (ADCs), chi\u1ebfn l\u01b0\u1ee3c h\u01b0\u1edbng t\u1edbi vi\u1ec7c ch\u1ec9 s\u1eed d\u1ee5ng c\u00e1c l\u1ecd thu\u1ed1c nguy\u00ean v\u1eb9n \u0111\u00e3 gi\u00fap gi\u1ea3m kho\u1ea3ng 25% chi ph\u00ed ti\u1ec1n thu\u1ed1c [2].\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><b>Kho\u1ea3ng th\u1eddi gian k\u00e9o d\u00e0i:<\/b><span style=\"font-weight: 400;\"> Trong c\u00f9ng m\u1ed9t b\u00e0i thuy\u1ebft tr\u00ecnh c\u1ee7a B\u00e1c s\u0129 Moes, t\u1ed1i \u01b0u h\u00f3a li\u1ec1u l\u01b0\u1ee3ng d\u1ef1a tr\u00ean m\u00f4 h\u00ecnh c\u0169ng c\u00f3 th\u1ec3 gi\u00fap b\u1ec7nh nh\u00e2n \u0111i\u1ec1u tr\u1ecb thu\u1eadn ti\u1ec7n h\u01a1n v\u00e0 \u0111\u1ed3ng th\u1eddi gi\u1ea3m chi ph\u00ed. Vi\u1ec7c x\u00e2y d\u1ef1ng c\u00e1c kho\u1ea3ng c\u00e1ch \u0111\u1ecbnh li\u1ec1u ph\u1ee5 thu\u1ed9c v\u00e0o tr\u1ecdng l\u01b0\u1ee3ng c\u01a1 th\u1ec3 \u0111\u1ed1i v\u1edbi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf \u0111i\u1ec3m ki\u1ec3m so\u00e1t mi\u1ec5n d\u1ecbch ti\u00eam d\u01b0\u1edbi da (v\u00ed d\u1ee5: nivolumab) \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 gi\u00fap ti\u1ebft ki\u1ec7m h\u01a1n 30% chi ph\u00ed thu\u1ed1c h\u00e0ng n\u0103m, trong khi v\u1eabn duy tr\u00ec nghi\u00eam ng\u1eb7t c\u00e1c ti\u00eau ch\u00ed v\u1ec1 hi\u1ec7u qu\u1ea3 l\u00e2m s\u00e0ng [2].<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h3 style=\"font-family: Inter !important; font-weight: 500 !important; font-size: 24px !important; line-height: 32px !important; letter-spacing: 0px !important;\">C) Th\u00fac \u0111\u1ea9y qu\u00e1 tr\u00ecnh ch\u1ea9n \u0111o\u00e1n li\u00ean t\u1ee5c<\/h3>\n<p><span style=\"font-weight: 400;\">Chuy\u1ec3n \u0111\u1ed5i k\u1ef9 thu\u1eadt s\u1ed1 v\u1ec1 c\u01a1 b\u1ea3n thay \u0111\u1ed5i v\u1ecb tr\u00ed c\u1ee7a ph\u00f2ng x\u00e9t nghi\u1ec7m trong ph\u1ea1m vi s\u1ef1 ch\u0103m s\u00f3c li\u00ean t\u1ee5c &#8211; \u0111\u00e2y kh\u00f4ng c\u00f2n l\u00e0 nh\u00e0 cung c\u1ea5p d\u1ecbch v\u1ee5 m\u00e0 l\u00e0 \u0111\u1ed1i t\u00e1c chi\u1ebfn l\u01b0\u1ee3c trong l\u0129nh v\u1ef1c tr\u1ecb li\u1ec7u:<\/span><\/p>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>T\u00edch h\u1ee3p EHR:<\/b><span style=\"font-weight: 400;\"> Ph\u00e1t tri\u1ec3n c\u00e1c c\u00f4ng c\u1ee5 nh\u01b0 ph\u1ea7n m\u1ec1m RoadMAB, t\u00edch h\u1ee3p MIPD v\u00e0 ML tr\u1ef1c ti\u1ebfp v\u00e0o EHR, t\u1ef1 \u0111\u1ed9ng h\u00f3a vi\u1ec7c hi\u1ec7u ch\u1ec9nh d\u1eef li\u1ec7u b\u1ec7nh nh\u00e2n c\u1ea7n thi\u1ebft v\u00e0 \u0111\u01a1n gi\u1ea3n h\u00f3a ph\u00e2n t\u00edch cho b\u00e1c s\u0129 l\u00e2m s\u00e0ng [3, 4]. \u0110\u1ed5i m\u1edbi n\u00e0y chuy\u1ec3n \u0111\u1ec1 xu\u1ea5t gi\u00e1 tr\u1ecb ch\u1ea9n \u0111o\u00e1n t\u1eeb k\u1ebft qu\u1ea3 ph\u00f2ng x\u00e9t nghi\u1ec7m t\u0129nh sang khuy\u1ebfn ngh\u1ecb \u0111i\u1ec1u tr\u1ecb cu\u1ed1i c\u00f9ng, c\u00f3 th\u1ec3 tri\u1ec3n khai.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>C\u00e1c x\u00e9t nghi\u1ec7m v\u00e0 gh\u00e9p k\u00eanh m\u1edbi:<\/b><span style=\"font-weight: 400;\"> Vi\u1ec7c \u0111\u1ea7u t\u01b0 chi\u1ebfn l\u01b0\u1ee3c v\u00e0o c\u00e1c x\u00e9t nghi\u1ec7m th\u1ebf h\u1ec7 m\u1edbi, ch\u1eb3ng h\u1ea1n nh\u01b0 k\u1ef9 thu\u1eadt LC-MS theo l\u01b0u \u00fd c\u1ee7a B\u00e1c s\u0129 Moes, cho ph\u00e9p \u0111o l\u01b0\u1eddng \u0111\u1ed3ng th\u1eddi n\u1ed3ng \u0111\u1ed9 c\u1ee7a nhi\u1ec1u lo\u1ea1i thu\u1ed1c ho\u1eb7c kh\u00e1ng th\u1ec3 kh\u00e1c nhau ch\u1ec9 trong m\u1ed9t m\u1eabu b\u1ec7nh ph\u1ea9m duy nh\u1ea5t c\u1ee7a b\u1ec7nh nh\u00e2n [2]. \u0110i\u1ec1u n\u00e0y gi\u00fap t\u0103ng c\u01b0\u1eddng danh m\u1ee5c d\u1ecbch v\u1ee5 c\u1ee7a ph\u00f2ng x\u00e9t nghi\u1ec7m, t\u0103ng hi\u1ec7u qu\u1ea3 v\u00e0 h\u1ed7 tr\u1ee3 c\u00e1c nhu c\u1ea7u ph\u1ee9c t\u1ea1p c\u1ee7a gi\u00e1m s\u00e1t sinh h\u1ecdc.\u00a0<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Nh\u1eefng hi\u1ec7u qu\u1ea3 n\u00e0y nh\u1ea5n m\u1ea1nh m\u1ed9t s\u1ef1 thay \u0111\u1ed5i m\u00f4 h\u00ecnh quan tr\u1ecdng: chuy\u1ec3n \u0111\u1ed5i k\u1ef9 thu\u1eadt s\u1ed1 trong TDM ho\u1ea1t \u0111\u1ed9ng nh\u01b0 m\u1ed9t b\u1ed9 t\u1ea1o gi\u00e1 tr\u1ecb, mang l\u1ea1i l\u1ee3i t\u1ee9c \u0111\u1ea7u t\u01b0 (ROI) r\u00f5 r\u00e0ng v\u00e0 \u0111\u00e1ng k\u1ec3 thay v\u00ec ch\u1ec9 ph\u00e1t sinh chi ph\u00ed.<\/span><\/p>\n<h2 style=\"font-family: Inter !important; font-weight: 500 !important; font-size: 28px !important; line-height: 36px !important; letter-spacing: 0px !important;\">L\u1ed9 tr\u00ecnh chuy\u1ec3n \u0111\u1ed5i: l\u1eddi k\u00eau g\u1ecdi h\u00e0nh \u0111\u1ed9ng v\u00ec s\u1ef1 l\u00e3nh \u0111\u1ea1o<\/h2>\n<p><span style=\"font-weight: 400;\">\u0110\u1ec3 hi\u1ec7n th\u1ef1c h\u00f3a m\u1ee9c ROI \u0111\u00e1ng k\u1ec3 n\u00e0y v\u00e0 duy tr\u00ec m\u1ed9t chu tr\u00ecnh ch\u1ea9n \u0111o\u00e1n ti\u00ean ti\u1ebfn, c\u1ea7n c\u00f3 m\u1ed9t chi\u1ebfn l\u01b0\u1ee3c ch\u1ee7 \u0111\u1ed9ng v\u00e0 c\u00f3 t\u1ea7m nh\u00ecn xa, nh\u1eb1m gi\u1ea3i quy\u1ebft \u0111\u1ed3ng th\u1eddi c\u1ea3 m\u1ee9c \u0111\u1ed9 s\u1eb5n s\u00e0ng c\u1ee7a t\u1ed5 ch\u1ee9c l\u1eabn qu\u1ea3n tr\u1ecb k\u1ef9 thu\u1eadt. \u0110\u1ed1i v\u1edbi c\u1ea5p l\u00e3nh \u0111\u1ea1o ph\u00f2ng th\u00ed nghi\u1ec7m v\u00e0 b\u1ec7nh vi\u1ec7n, con \u0111\u01b0\u1eddng h\u01b0\u1edbng t\u1edbi kh\u00f4ng ch\u1ec9 l\u00e0 \u00e1p d\u1ee5ng c\u00f4ng ngh\u1ec7 m\u00e0 c\u00f2n l\u00e0 th\u00fac \u0111\u1ea9y thay \u0111\u1ed5i th\u1ec3 ch\u1ebf. \u0110\u1ec3 c\u00f3 th\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c \u0111i\u1ec1u n\u00e0y, c\u1ea7n c\u00f3 m\u1ed9t t\u1eadp h\u1ee3p h\u00e0nh \u0111\u1ed9ng r\u00f5 r\u00e0ng:<\/span><\/p>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>H\u1ee3p t\u00e1c li\u00ean ng\u00e0nh:<\/b><span style=\"font-weight: 400;\"> \u0110\u1ea1t \u0111\u01b0\u1ee3c t\u1ea7m nh\u00ecn to\u00e0n di\u1ec7n v\u1ec1 ch\u0103m s\u00f3c t\u00edch h\u1ee3p \u0111\u00f2i h\u1ecfi ph\u1ea3i ph\u00e1 v\u1ee1 c\u00e1c r\u00e0o c\u1ea3n ng\u0103n c\u00e1ch truy\u1ec1n th\u1ed1ng. H\u1ee3p t\u00e1c hi\u1ec7u qu\u1ea3 l\u00e0 \u0111i\u1ec1u c\u1ea7n thi\u1ebft gi\u1eefa c\u00e1c b\u00ean li\u00ean quan ch\u00ednh, bao g\u1ed3m nh\u00e0 thu\u1ed1c l\u00e2m s\u00e0ng, d\u1ecbch v\u1ee5 ph\u00f2ng th\u00ed nghi\u1ec7m, Ph\u00e1t tri\u1ec3n CNTT \/ Ph\u1ea7n m\u1ec1m v\u00e0 qu\u1ea3n l\u00fd b\u1ec7nh vi\u1ec7n, \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o t\u00edch h\u1ee3p c\u00f4ng c\u1ee5 li\u1ec1n m\u1ea1ch v\u00e0 \u00e1p d\u1ee5ng quy tr\u00ecnh l\u00e0m vi\u1ec7c [1].<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Qu\u1ea3n tr\u1ecb v\u00e0 ki\u1ec3m so\u00e1t ch\u1ea5t l\u01b0\u1ee3ng:<\/b><span style=\"font-weight: 400;\"> C\u00e1c c\u00f4ng ngh\u1ec7 k\u1ef9 thu\u1eadt s\u1ed1, \u0111\u1eb7c bi\u1ec7t l\u00e0 AI, \u0111\u00f2i h\u1ecfi qu\u1ea3n l\u00fd c\u1ea9n th\u1eadn. L\u00e3nh \u0111\u1ea1o ph\u1ea3i \u01b0u ti\u00ean ch\u1ea5t l\u01b0\u1ee3ng d\u1eef li\u1ec7u m\u1ea1nh m\u1ebd, x\u00e1c th\u1ef1c b\u00ean ngo\u00e0i nghi\u00eam ng\u1eb7t v\u00e0 qu\u1ea3n tr\u1ecb m\u1ea1nh m\u1ebd \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o r\u1eb1ng c\u00e1c m\u00f4 h\u00ecnh &#8211; \u0111\u1eb7c bi\u1ec7t l\u00e0 nh\u1eefng m\u00f4 h\u00ecnh t\u1eadn d\u1ee5ng RWD &#8211; an to\u00e0n v\u00e0 \u0111\u00e1ng tin c\u1eady cho vi\u1ec7c ch\u0103m s\u00f3c b\u1ec7nh nh\u00e2n r\u1ed9ng r\u00e3i [8]. Thi\u1ebft l\u1eadp c\u00e1c quy tr\u00ecnh r\u00f5 r\u00e0ng gi\u00fap b\u1ea3o v\u1ec7 kh\u1ecfi c\u00e1c tr\u00e1ch nhi\u1ec7m ph\u00e1p l\u00fd v\u00e0 \u0111\u1ea3m b\u1ea3o an to\u00e0n cho b\u1ec7nh nh\u00e2n.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>T\u1eadp trung \u0111\u1ea7u t\u01b0:<\/b><span style=\"font-weight: 400;\"> \u0110\u1ea7u t\u01b0 trong t\u01b0\u01a1ng lai n\u00ean t\u1eadp trung v\u00e0o vi\u1ec7c t\u00edch h\u1ee3p h\u1ec7 th\u1ed1ng thay v\u00ec mua c\u00e1c c\u00f4ng c\u1ee5 ri\u00eang l\u1ebb. \u0110i\u1ec1u n\u00e0y bao g\u1ed3m t\u00edch h\u1ee3p \u0111\u1ea7y \u0111\u1ee7 d\u01b0\u1ee3c l\u1ef1c h\u1ecdc (m\u00f4 h\u00ecnh PK \/ PD), c\u00e1c kh\u00e1i ni\u1ec7m ti\u00ean ti\u1ebfn nh\u01b0 b\u1ea3n sao k\u1ef9 thu\u1eadt s\u1ed1 v\u00e0 kh\u1ea3 n\u0103ng AI \u0111\u00e3 \u0111\u01b0\u1ee3c tinh ch\u1ec9nh m\u1ed9t c\u00e1ch tr\u1ef1c ti\u1ebfp v\u00e0o c\u00e1c b\u1ea3ng \u0111i\u1ec1u khi\u1ec3n h\u1ed7 tr\u1ee3 quy\u1ebft \u0111\u1ecbnh l\u00e2m s\u00e0ng. Ph\u01b0\u01a1ng ph\u00e1p n\u00e0y s\u1ebd hi\u1ec7n \u0111\u1ea1i h\u00f3a v\u00e0 chuy\u1ec3n \u0111\u1ed5i h\u01a1n n\u1eefa TDM, \u0111\u1ea3m b\u1ea3o m\u1ee5c ti\u00eau cu\u1ed1i c\u00f9ng: <\/span><b><i>thu\u1ed1c ph\u00f9 h\u1ee3p, \u0111\u00fang li\u1ec1u l\u01b0\u1ee3ng, \u0111\u00fang th\u1eddi \u0111i\u1ec3m<\/i><\/b><span style=\"font-weight: 400;\"> cho t\u1eebng b\u1ec7nh nh\u00e2n [2, 3].<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Cu\u1ed1i c\u00f9ng, t\u01b0\u01a1ng lai k\u1ef9 thu\u1eadt s\u1ed1 c\u1ee7a TDM &#8211; nh\u01b0 \u0111\u00e3 \u0111\u01b0\u1ee3c kh\u1eb3ng \u0111\u1ecbnh b\u1edfi nh\u1eefng chuy\u00ean gia \u0111\u1ea7u ng\u00e0nh n\u00e0y \u2013 ch\u00ednh l\u00e0 s\u1ef1 ch\u00ednh x\u00e1c \u0111i k\u00e8m v\u1edbi m\u1ee5c ti\u00eau. \u0110\u00e2y l\u00e0 c\u01a1 h\u1ed9i \u0111\u1ec3 ch\u1ea9n \u0111o\u00e1n tr\u1edf th\u00e0nh m\u1ed9t \u0111\u1ed1i t\u00e1c t\u00edch h\u1ee3p, n\u0103ng \u0111\u1ed9ng trong ch\u0103m s\u00f3c. S\u1ef1 chuy\u1ec3n \u0111\u1ed5i n\u00e0y mang l\u1ea1i cho c\u00e1c nh\u00e0 l\u00e3nh \u0111\u1ea1o m\u1ed9t l\u1ee3i th\u1ebf c\u1ea1nh tranh r\u00f5 r\u1ec7t v\u1edbi nh\u1eefng gi\u00e1 tr\u1ecb l\u1ee3i nhu\u1eadn c\u00f3 th\u1ec3 \u0111o l\u01b0\u1eddng \u0111\u01b0\u1ee3c; nh\u01b0ng chi\u1ebfn th\u1eafng th\u1ef1c s\u1ef1 ch\u00ednh l\u00e0 kh\u1ea3 n\u0103ng n\u00e2ng t\u1ea7m m\u1ed9t c\u00e1ch c\u0103n b\u1ea3n tr\u1ea3i nghi\u1ec7m c\u1ee7a con ng\u01b0\u1eddi \u0111\u1ed1i v\u1edbi y h\u1ecdc, b\u1eb1ng c\u00e1ch bi\u1ebfn s\u1ef1 an to\u00e0n c\u00e1 th\u1ec3 h\u00f3a tr\u1edf th\u00e0nh ti\u00eau chu\u1ea9n c\u1ed1t l\u00f5i cho t\u1ea5t c\u1ea3 m\u1ecdi ng\u01b0\u1eddi.<\/span><\/p>\n<hr \/>\n<p><i><span style=\"font-weight: 400;\">T\u00e0i li\u1ec7u tham kh\u1ea3o<\/span><\/i><\/p>\n<p><a href=\"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bcp.14426\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[1] <\/span><\/a><span style=\"font-weight: 400;\">Mizuno, T., Vinks, A.A., Fukuda, T., Rosenheck, R., Wetterland, L., de Leon, J., Hartman, S., Arnold, L.M. v\u00e0 Patino, L.R. (2022) &#8216;Clinical implementation of pharmacogenetics and model-informed precision dosing to improve patient care&#8217;, <\/span><i><span style=\"font-weight: 400;\">British Journal of Clinical Pharmacology<\/span><\/i><span style=\"font-weight: 400;\">, 88(4), pp. 1418\u20131426.<\/span><\/p>\n<p><a href=\"https:\/\/docs.google.com\/document\/d\/1BvNl8lAYxfy36xmXXwKktXdTbsklaISkKwx1QEqg9no\/edit?usp=drive_link\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[2]<\/span><\/a><span style=\"font-weight: 400;\"> Moes, D.J. (2025) &#8216;Model Informed (precision) dosing of biologics in (hemato)oncology: challenges and opportunities?&#8217;, <\/span><i><span style=\"font-weight: 400;\">H\u1ed9i ngh\u1ecb qu\u1ed1c t\u1ebf l\u1ea7n th\u1ee9 23 c\u1ee7a Hi\u1ec7p h\u1ed9i gi\u00e1m s\u00e1t thu\u1ed1c \u0111i\u1ec1u tr\u1ecb v\u00e0 \u0111\u1ed9c h\u1ecdc l\u00e2m s\u00e0ng (IATDMCT)<\/span><\/i><span style=\"font-weight: 400;\">. Kh\u00e1ch s\u1ea1n Grand Copthorne Waterfront, Singapore, 21-24 th\u00e1ng 9.<\/span><\/p>\n<p><a href=\"https:\/\/docs.google.com\/document\/d\/1Uit7t_CVMWfrXb8H3bizV4Oqs0B3xdEKcnCWdBsj1MQ\/edit?usp=drive_link\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[3]<\/span><\/a><span style=\"font-weight: 400;\"> Mizuno, T. (2025) &#8216;Leveraging machine learning and decision support dashboard to facilitate precision dosing in pediatric patient care&#8217;, <\/span><i><span style=\"font-weight: 400;\">H\u1ed9i ngh\u1ecb qu\u1ed1c t\u1ebf l\u1ea7n th\u1ee9 23 c\u1ee7a Hi\u1ec7p h\u1ed9i gi\u00e1m s\u00e1t thu\u1ed1c \u0111i\u1ec1u tr\u1ecb v\u00e0 \u0111\u1ed9c h\u1ecdc l\u00e2m s\u00e0ng (IATDMCT)<\/span><\/i><span style=\"font-weight: 400;\">. Kh\u00e1ch s\u1ea1n Grand Copthorne Waterfront, Singapore, 21-24 th\u00e1ng 9.<\/span><\/p>\n<p><a href=\"https:\/\/academic.oup.com\/ibdjournal\/article\/29\/8\/1342\/6839996?login=false\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[4] <\/span><\/a><span style=\"font-weight: 400;\">Colman, R.J., Xiong, Y., Mizuno, T., Xie, C., Vinks, A.A., Hyams, J.S., Denson, L.A. v\u00e0 Minar, P. (2023) &#8216;Model-informed Precision Dosing for Biologics Is Now Available at the Bedside: A Roadmap for Strategies and Considerations for Real-world Implementation&#8217;, <\/span><i><span style=\"font-weight: 400;\">Inflammatory Bowel Diseases<\/span><\/i><span style=\"font-weight: 400;\">, 29(1), pp. 119\u2013127. doi: 10.1093\/ibd\/izac063.<\/span><\/p>\n<p><a href=\"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/psp4.12745\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[5]<\/span><\/a><span style=\"font-weight: 400;\"> Maier, C., Hartung, N., Kloft, C., Huisinga, W. v\u00e0 Henrich, W. (2021) &#8216;A continued learning approach for model-informed precision dosing: updating models in clinical practice&#8217;, <\/span><i><span style=\"font-weight: 400;\">CPT: Pharmacometrics &amp; Systems Pharmacology<\/span><\/i><span style=\"font-weight: 400;\">, 10(4), pp. 311\u2013321.<\/span><\/p>\n<p><a href=\"https:\/\/docs.google.com\/document\/d\/14aw8je3yf181fa3pnVx8u0AWBQldlrt1yC4K3zV2Npg\/edit?usp=drive_link\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[6] <\/span><\/a><span style=\"font-weight: 400;\">Yamada, T. (2025) &#8216;Real-World Big Data Insights for Advancing Therapeutic Drug Monitoring and Clinical Toxicology&#8217;, <\/span><i><span style=\"font-weight: 400;\">H\u1ed9i ngh\u1ecb qu\u1ed1c t\u1ebf l\u1ea7n th\u1ee9 23 c\u1ee7a Hi\u1ec7p h\u1ed9i gi\u00e1m s\u00e1t thu\u1ed1c \u0111i\u1ec1u tr\u1ecb v\u00e0 \u0111\u1ed9c h\u1ecdc l\u00e2m s\u00e0ng (IATDMCT)<\/span><\/i><span style=\"font-weight: 400;\">. Kh\u00e1ch s\u1ea1n Grand Copthorne Waterfront, Singapore, 21-24 th\u00e1ng 9.<\/span><\/p>\n<p><a href=\"https:\/\/academic.oup.com\/jac\/article\/78\/10\/2395\/7226352\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[7]<\/span><\/a><span style=\"font-weight: 400;\"> Pai Mangalore, R., Peel, T.N., Udy, A.A. v\u00e0 Peleg, A.Y. (2023) &#8216;The clinical application of beta-lactam antibiotic therapeutic drug monitoring in the critical care setting&#8217;, Journal of Antimicrobial Chemotherapy, 78(10), pp. 2395\u20132405. C\u00f3 s\u1eb5n t\u1ea1i: <\/span><a href=\"https:\/\/doi.org\/10.1093\/jac\/dkad223\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/doi.org\/10.1093\/jac\/dkad223<\/span><\/a><span style=\"font-weight: 400;\"> (Truy c\u1eadp: ng\u00e0y 26 th\u00e1ng 1 n\u0103m 2026).<\/span><\/p>\n<p><a href=\"https:\/\/docs.google.com\/document\/d\/1XDRqjvduAq3dbnFsj_bxBKyy4p0-XekBPtOhiKOAP8o\/edit?usp=drive_link\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[8] <\/span><\/a><span style=\"font-weight: 400;\">Legg, A. (2025) &#8216;TDM research in the digital age?&#8217;, <\/span><i><span style=\"font-weight: 400;\">H\u1ed9i ngh\u1ecb qu\u1ed1c t\u1ebf l\u1ea7n th\u1ee9 23 c\u1ee7a Hi\u1ec7p h\u1ed9i gi\u00e1m s\u00e1t thu\u1ed1c \u0111i\u1ec1u tr\u1ecb v\u00e0 \u0111\u1ed9c h\u1ecdc l\u00e2m s\u00e0ng (IATDMCT)<\/span><\/i><span style=\"font-weight: 400;\">. Kh\u00e1ch s\u1ea1n Grand Copthorne Waterfront, Singapore, 21-24 th\u00e1ng 9.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Khi \u0111\u1ec1 c\u1eadp \u0111\u1ebfn \u0111i\u1ec1u tr\u1ecb, th\u00e1ch th\u1ee9c l\u00e2m s\u00e0ng c\u1ed1t l\u00f5i th\u01b0\u1eddng \u0111\u01b0\u1ee3c g\u00f3i g\u1ecdn trong m\u1ed9t c\u00e2u h\u1ecfi mang t\u00ednh quy\u1ebft \u0111\u1ecbnh: li\u1ec1u l\u01b0\u1ee3ng thu\u1ed1c bao nhi\u00eau l\u00e0 \u0111\u1ee7, v\u00e0 th\u1eddi gian \u0111i\u1ec1u tr\u1ecb n\u00ean k\u00e9o d\u00e0i bao l\u00e2u? Trong su\u1ed1t m\u1ed9t th\u1eddi gian d\u00e0i, kh\u00e1t v\u1ecdng h\u01b0\u1edbng t\u1edbi y h\u1ecdc c\u00e1 th\u1ec3 [&hellip;]<\/p>\n","protected":false},"author":97,"featured_media":147637,"parent":0,"menu_order":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"tags":[],"pillarandcategory":[298,307,296,300],"reporter":[15263],"class_list":["post-149761","acf_article","type-acf_article","status-publish","has-post-thumbnail","hentry","pillarandcategory-conferences","pillarandcategory-digital-transformation","pillarandcategory-event-coverage","pillarandcategory-management","reporter-willaine-g-tan"],"acf":[],"_links":{"self":[{"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/acf_article\/149761","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/acf_article"}],"about":[{"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/types\/acf_article"}],"author":[{"embeddable":true,"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/users\/97"}],"version-history":[{"count":1,"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/acf_article\/149761\/revisions"}],"predecessor-version":[{"id":149950,"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/acf_article\/149761\/revisions\/149950"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/media\/147637"}],"wp:attachment":[{"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/media?parent=149761"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/tags?post=149761"},{"taxonomy":"pillarandcategory","embeddable":true,"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/pillarandcategory?post=149761"},{"taxonomy":"reporter","embeddable":true,"href":"https:\/\/labinsights.com\/vi\/wp-json\/wp\/v2\/reporter?post=149761"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}