{"id":141304,"date":"2021-03-18T05:13:28","date_gmt":"2021-03-18T05:13:28","guid":{"rendered":"https:\/\/labinsights.com\/acf_article\/%e5%86%a0%e7%8a%b6%e7%97%85%e6%af%92-ngs%ef%bc%88%e4%b8%8b%e4%b8%80%e4%bb%a3%e6%b5%8b%e5%ba%8f%ef%bc%89%e5%b7%a5%e5%85%b7%e5%9c%a8%e7%96%ab%e6%83%85%e6%9c%9f%e9%97%b4%e7%9a%84%e5%8f%91%e5%b1%95\/"},"modified":"2026-01-22T04:23:43","modified_gmt":"2026-01-22T04:23:43","slug":"how-ngs-tools-have-shaped-the-covid-19-pandemic-response","status":"publish","type":"acf_article","link":"https:\/\/labinsights.com\/zhcn\/operations\/sequencing\/how-ngs-tools-have-shaped-the-covid-19-pandemic-response\/","title":{"rendered":"\u51a0\u72b6\u75c5\u6bd2 NGS\uff08\u4e0b\u4e00\u4ee3\u6d4b\u5e8f\uff09\u5de5\u5177\u5728\u75ab\u60c5\u671f\u95f4\u7684\u53d1\u5c55\u5386\u7a0b"},"content":{"rendered":"

\u7b80\u4ecb\u2014\u2014COVID19 \u4e0b\u4e00\u4ee3\u6d4b\u5e8f\u5de5\u5177<\/strong><\/h2>\n

\u7531\u4e8e\u51a0\u72b6\u75c5\u6bd2 NGS \u7684\u53ef\u7528\u6027\u4e0e\u53ef\u8d1f\u62c5\u6027\uff0c\u4e0b\u4e00\u4ee3\u6d4b\u5e8f (NGS) \u5de5\u5177\u5df2\u6210\u4e3a\u79d1\u5b66\u754c\u5e94\u5bf9 COVID-19 \u75ab\u60c5\u7684\u5fc5\u5907\u7ec4\u6210\u90e8\u5206\u3002\u57fa\u4e8e\u75c5\u6bd2\u57fa\u56e0\u7ec4\u5e8f\u5217\uff0c\u57fa\u56e0\u7ec4\u6570\u636e\u5b9e\u73b0\u4e86\u5bf9\u75c5\u539f\u4f53\u524d\u6240\u672a\u6709\u7684\u76d1\u6d4b\uff0c\u5e76\u63a8\u52a8\u4e86\u8bca\u65ad\u68c0\u6d4b\u4e0e\u75ab\u82d7\u7684\u5feb\u901f\u5f00\u53d1\u3002<\/p>\n

\u9488\u5bf9\u6025\u6027\u91cd\u75c7\u547c\u5438\u7efc\u5408\u5f81\u51a0\u72b6\u75c5\u6bd2 2 (SARS-CoV-2) \u57fa\u56e0\u7ec4\u7684\u7b2c\u4e00\u6279\u7814\u7a76\u6765\u81ea\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u4e0a\u6d77\u5e02\u516c\u5171\u536b\u751f\u4e34\u5e8a\u4e2d\u5fc3\u7684\u79d1\u5b66\u5bb6\u3002Yong-Zhen Zhang \u6559\u6388\u7387\u9886\u7684\u56e2\u961f\u5bf9 2019 \u5e74 12 \u6708 26 \u65e5\u4ece\u6b66\u6c49\u4e00\u540d\u60a3\u8005\u8eab\u4e0a\u91c7\u96c6\u7684\u5206\u79bb\u7269\u8fdb\u884c\u4e86\u6d4b\u5e8f\uff1b\u4ed6\u4eec\u4e8e 2020 \u5e74 1 \u6708 5 \u65e5\u5b8c\u6210\u4e86\u57fa\u56e0\u7ec4\u7ec4\u88c5\u3002 \u8be5\u56e2\u961f\u5c06\u8be5\u57fa\u56e0\u7ec4\u5e8f\u5217\u5171\u4eab\u7ed9\u4e86\u957f\u671f\u7814\u7a76\u4f19\u4f34\u2014\u2014University of Sydney \u7684\u75c5\u6bd2\u5b66\u5bb6 Eddie Holmes \u6559\u6388\u3002\u4ed6\u4e8e 1 \u6708 11 \u65e5\u5c06\u5e8f\u5217\u4e0a\u4f20\u81f3\u516c\u5171\u6570\u636e\u5e93\uff0c\u5411\u5168\u4e16\u754c\u4ecb\u7ecd\u4e86\u8be5\u6709\u673a\u4f53\u7684\u57fa\u56e0\u7ec4\u3002<\/p>\n

\u8be5\u5e8f\u5217\u6570\u636e\u7acb\u5373\u88ab\u90e8\u7f72\u7528\u4e8e\u75ab\u82d7\u5f00\u53d1\u5de5\u4f5c\uff0c\u4e3a\u968f\u540e\u9996\u6279\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e4b\u5916\u6295\u5165\u4f7f\u7528\u7684\u4e24\u79cd mRNA \u75ab\u82d7\u5960\u5b9a\u4e86\u57fa\u7840\u3002\u8be5\u6570\u636e\u4e5f\u662f\u4eca\u5929\u4f7f\u7528\u7684\u8bb8\u591a\u6025\u6027\u91cd\u75c7\u547c\u5438\u7efc\u5408\u5f81\u51a0\u72b6\u75c5\u6bd2 2 (SARS-CoV-2) \u8bca\u65ad\u68c0\u6d4b\u7684\u57fa\u7840\u3002<\/p>\n

\u4f46\u6d4b\u5e8f\u5de5\u4f5c\u5e76\u672a\u5c31\u6b64\u505c\u6b62\u3002\u5230 2021 \u5e74\u521d\uff0c\u5df2\u5bf9 60 \u591a\u4e07\u4e2a\u75c5\u6bd2\u57fa\u56e0\u7ec4\u8fdb\u884c\u6d4b\u5e8f\uff0c\u5e76\u5728 GISAID \u6570\u636e\u5e93\u4e2d\u516c\u5f00\u5171\u4eab [1]\u3002\u5728\u5982\u6b64\u77ed\u7684\u65f6\u95f4\u5185\u751f\u6210\u7684\u57fa\u56e0\u7ec4\u5e8f\u5217\u6570\u91cf\uff0c\u8d85\u8fc7\u4e86\u9488\u5bf9\u4efb\u4f55\u5176\u4ed6\u75c5\u539f\u4f53\u6240\u4ea7\u751f\u7684\u603b\u91cf\u3002\u8fd9\u4e00\u5b9d\u8d35\u7684\u6570\u636e\u96c6\u4f7f\u79d1\u5b66\u5bb6\u80fd\u591f\u8ffd\u8e2a\u75c5\u6bd2\u4f20\u64ad\u8def\u5f84\u3001\u901a\u8fc7\u7cfb\u7edf\u53d1\u80b2\u6570\u636e\u7ed8\u5236\u4f20\u64ad\u56fe\u8c31\u3001\u6d4b\u7b97\u75c5\u6bd2\u53d8\u5f02\u901f\u7387\u3001\u53d1\u73b0\u65b0\u51fa\u73b0\u4e14\u503c\u5f97\u5173\u6ce8\u7684\u53d8\u5f02\u682a\uff0c\u5e76\u8bc6\u522b\u8d85\u7ea7\u4f20\u64ad\u4e8b\u4ef6\u3002<\/p>\n

\u5982\u679c\u6ca1\u6709\u4ece\u5982\u6b64\u591a\u7684\u5206\u79bb\u682a\u4e2d\u751f\u6210\u7684\u5168\u57fa\u56e0\u7ec4\u5e8f\u5217\u6570\u636e\uff0c\u8fd9\u4e9b\u6210\u679c\u6839\u672c\u65e0\u6cd5\u5b9e\u73b0\u3002\u5728\u7f8e\u56fd\u548c\u82f1\u56fd\u7b49\u56fd\u5bb6\/\u5730\u533a\uff0c\u5b9e\u9a8c\u5ba4\u5df2\u7ecf\u5efa\u7acb\u4e86\u6d4b\u5e8f\u5de5\u4f5c\u6d41\u7a0b [2]\uff0c\u65e8\u5728\u5bb9\u7eb3\u8fd0\u884c\u5206\u5b50\u8bca\u65ad\u68c0\u6d4b\u540e\u9057\u7559\u7684\u5c11\u91cf\u6b8b\u7559\u6837\u672c\u3002\u5c3d\u7ba1\u8fd9\u573a\u75ab\u60c5\u582a\u79f0\u6bc1\u706d\u6027\uff0c\u4f46\u6765\u81ea\u5168\u7403\u5b9e\u9a8c\u5ba4\u7684 NGS \u6570\u636e\u8d21\u732e\u5df2\u7136\u5f00\u521b\u4e86\u75c5\u6bd2\u57fa\u56e0\u7ec4\u5b66\u7814\u7a76\u7684\u9ec4\u91d1\u65f6\u4ee3\u3002<\/p>\n

\u4f8b\u5982\uff0c\u65e5\u672c\u7684\u79d1\u5b66\u5bb6\u5df2\u7ecf\u51fa\u5177\u5e76\u516c\u5f00\u5206\u4eab\u4e86\u6570\u4e07\u4e2a\u6025\u6027\u91cd\u75c7\u547c\u5438\u7efc\u5408\u5f81\u51a0\u72b6\u75c5\u6bd2 2 (SARS-CoV-2) \u57fa\u56e0\u7ec4\u5e8f\u5217\u3002\u8fd9\u4e9b\u4fe1\u606f\u4f7f\u4ed6\u4eec\u5f97\u4ee5\u53d1\u73b0\u6700\u521d\u5728\u82f1\u56fd\u3001\u5357\u975e\u548c\u5df4\u897f\u8bc6\u522b\u7684\u65b0\u578b\u53d8\u5f02\u6bd2\u682a\u5df2\u5c40\u90e8\u4f20\u5165 [3]\uff0c\u8fd9\u4e9b\u53d8\u5f02\u6bd2\u682a\u6bd4\u539f\u59cb\u6bd2\u682a\u66f4\u5177\u4f20\u67d3\u6027\uff0c\u5e76\u53ef\u80fd\u524a\u5f31\u67d0\u4e9b\u75ab\u82d7\u7684\u4fdd\u62a4\u6548\u679c\u3002\u6700\u8fd1\u4ece\u65e5\u672c\u5b58\u5165\u516c\u5171\u6570\u636e\u5e93\u7684\u5e8f\u5217\u6765\u81ea Nagasaki University\u3001National Institute of Infectious Diseases \u4ee5\u53ca Ibaraki Prefectural Institute of Public Health\u3002<\/p>\n

\u4e9a\u592a\u5730\u533a [4]\u00a0\u6700\u8fd1\u8d21\u732e\u7684\u5176\u4ed6\u57fa\u56e0\u7ec4\u5e8f\u5217\u6765\u81ea\u5b5f\u52a0\u62c9\u56fd\u3001\u6587\u83b1\u3001\u4e2d\u56fd\u3001\u4e2d\u56fd\u9999\u6e2f\u3001\u5370\u5ea6 [5]\u3001\u5370\u5ea6\u5c3c\u897f\u4e9a [6]\u3001\u83f2\u5f8b\u5bbe\u3001\u97e9\u56fd\u548c\u6fb3\u5927\u5229\u4e9a\u3002\u67d0\u4e9b\u673a\u6784\u6b63\u5728\u5229\u7528\u793e\u4ea4\u5a92\u4f53\u8ba9\u5c45\u6c11\u4e86\u89e3\u6700\u65b0\u4fe1\u606f\u3002\u4f8b\u5982\uff0cPhilippine Genome Center \u6700\u8fd1\u53d1\u63a8\u79f0\uff1a\u201c\u7ecf PGC DNA \u6d4b\u5e8f\u6838\u5fc3\u5b9e\u9a8c\u5ba4\u901a\u8fc7\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\uff0c\u9996\u6b21\u53d1\u73b0\u4e86\u5728\u523a\u7a81\u86cb\u767d\u533a\u57df\u643a\u5e26\u591a\u4e2a\u503c\u5f97\u5173\u6ce8\u7a81\u53d8\u7684\u6025\u6027\u91cd\u75c7\u547c\u5438\u7efc\u5408\u5f81\u51a0\u72b6\u75c5\u6bd2 2 (SARS-CoV-2) \u53d8\u4f53\uff0c\u5176\u5df2\u5728\u83f2\u5f8b\u5bbe\u5b8c\u6210\u57fa\u56e0\u7ec4\u7279\u5f81\u5206\u6790\uff0c\u8be5\u53d8\u4f53\u5728 2021 \u5e74 3 \u6708 10 \u65e5\u6b63\u5f0f\u88ab\u547d\u540d\u4e3a Lineage P.3\u3002\u201d<\/p>\n

\u90a3\u4e9b\u5bf9\u8db3\u91cf\u4e14\u6709\u4ee3\u8868\u6027\u7684 COVID-19 \u75c5\u4f8b\u8fdb\u884c\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u7684\u56fd\u5bb6\/\u5730\u533a\uff0c\u6b63\u5728\u6301\u7eed\u63d0\u4f9b\u5173\u952e\u4fe1\u606f\uff0c\u5e2e\u52a9\u4eba\u4eec\u4e86\u89e3\u75c5\u6bd2\u7684\u6f14\u53d8\u8d8b\u52bf\uff0c\u4ee5\u53ca\u54ea\u4e9b\u7a81\u53d8\u6700\u503c\u5f97\u8b66\u60d5\u3002\u4f8b\u5982\uff0c\u6700\u521d\u5728\u82f1\u56fd\u68c0\u6d4b\u5230\u7684 B.1.1.7 \u53d8\u4f53\u548c\u5728\u5357\u975e\u53d1\u73b0\u7684 B.1.351 \u53d8\u4f53\uff0c\u5176\u643a\u5e26\u7684\u7a81\u53d8\u6570\u91cf\u8fdc\u8d85\u6839\u636e\u6025\u6027\u91cd\u75c7\u547c\u5438\u7efc\u5408\u5f81\u51a0\u72b6\u75c5\u6bd2 2 (SARS-CoV-2) \u6807\u51c6\u8fdb\u5316\u901f\u7387\u6240\u9884\u671f [7] \u7684\u6c34\u5e73\uff0c\u56e0\u6b64\u79d1\u5b66\u5bb6\u63a8\u6d4b\u8fd9\u4e9b\u4f20\u67d3\u6027\u66f4\u5f3a\u7684\u53d8\u4f53\u53ef\u80fd\u6f14\u5316\u4ea7\u751f\u81ea\u957f\u671f\u611f\u67d3\u60a3\u8005\u4f53\u5185 [8]\u3002\u5927\u91cf\u7a81\u53d8\u53ef\u80fd\u53cd\u6620\u4e86\u75c5\u6bd2\u5728\u514d\u75ab\u7cfb\u7edf\u65bd\u52a0\u7684\u6301\u7eed\u4e14\u5f3a\u70c8\u7684\u9009\u62e9\u6027\u538b\u529b\u4e0b\u6240\u4ea7\u751f\u7684\u8fdb\u5316\u3002<\/p>\n

\u5728\u4e00\u4e9b\u56fd\u5bb6\/\u5730\u533a\uff0cNGS \u5de5\u5177\u5df2\u88ab\u5e94\u7528\u4e8e\u57fa\u4e8e\u5e9f\u6c34\u7684\u793e\u533a\u76d1\u6d4b\u8ba1\u5212 [9]\u3002\u793e\u533a\u5e9f\u6c34\u4e2d\u75c5\u6bd2\u591a\u6837\u6027\u4e0e\u8f7d\u91cf\u7684\u53d8\u5316\u8d8b\u52bf\uff0c\u5f80\u5f80\u80fd\u63d0\u524d\u6570\u5468\u9884\u793a\u8be5\u5730\u533a\u540e\u7eed\u5c06\u51fa\u73b0\u7684\u4e34\u5e8a\u75c5\u4f8b\u60c5\u51b5\uff1b\u8fd9\u4e9b\u4fe1\u606f\u6709\u52a9\u4e8e\u6307\u5bfc\u516c\u5171\u536b\u751f\u653f\u7b56\u7684\u5236\u5b9a\uff0c\u7279\u522b\u662f\u5728\u5b9e\u65bd\u533a\u57df\u6027\u5c01\u9501\u7b49\u7f13\u89e3\u63aa\u65bd\u65f6\u683c\u5916\u6709\u6548\u3002<\/p>\n

\u53e6\u5916\uff0c\u4e00\u9879\u540d\u4e3a MetaSUB [10] \u7684\u5fd7\u613f\u8005\u9a71\u52a8\u9879\u76ee\u901a\u8fc7\u91c7\u96c6\u5168\u7403\u5404\u5927\u57ce\u5e02\u516c\u5171\u4ea4\u901a\u7cfb\u7edf\u7b49\u516c\u5171\u573a\u6240\u7684\u6837\u672c\u8fdb\u884c\u5b8f\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u3002\u53bb\u5e74\uff0c\u8fd9\u4e9b\u6837\u672c\u5305\u62ec\u6025\u6027\u91cd\u75c7\u547c\u5438\u7efc\u5408\u5f81\u51a0\u72b6\u75c5\u6bd2 2 (SARS-CoV-2) \u57fa\u56e0\u7ec4\uff0c\u6570\u636e\u4e0e\u8fd9\u4e9b\u5730\u533a\u7684\u4e34\u5e8a\u8d8b\u52bf\u57fa\u672c\u76f8\u7b26\u3002<\/p>\n

\u201c\u968f\u7740\u8d8a\u6765\u8d8a\u591a\u7684\u56fd\u5bb6\u5f00\u59cb\u5b9e\u65bd\u6d4b\u5e8f\u8ba1\u5212\uff0c\u5c06\u6709\u66f4\u591a\u673a\u4f1a\u66f4\u597d\u5730\u4e86\u89e3\u65b0\u5174\u75c5\u539f\u4f53\u7684\u4e16\u754c\u53ca\u5176\u5728\u5404\u79cd\u6c14\u5019\u3001\u751f\u6001\u7cfb\u7edf\u3001\u6587\u5316\u3001\u751f\u6d3b\u65b9\u5f0f\u548c\u751f\u7269\u7fa4\u4e2d\u4e0e\u4eba\u7c7b\u548c\u52a8\u7269\u7684\u76f8\u4e92\u4f5c\u7528\u201d\uff0cWorld Health Organisation \u5168\u7403\u4f20\u67d3\u6027\u5371\u5bb3\u9632\u8303\u53f8\u53f8\u957f Sylvie Briand \u5728\u6700\u8fd1\u53d1\u5e03\u7684\u4e00\u4efd\u6025\u6027\u91cd\u75c7\u547c\u5438\u7efc\u5408\u5f81\u51a0\u72b6\u75c5\u6bd2 2 (SARS-CoV-2) \u57fa\u56e0\u7ec4\u6d4b\u5e8f\u4f7f\u7528\u6307\u5357\u4e2d\u5199\u9053 [11]\uff0c\u201c\u5982\u679c\u6211\u4eec\u60f3\u9488\u5bf9\u672a\u6765\u7684\u5a01\u80c1\u505a\u597d\u66f4\u5145\u5206\u7684\u51c6\u5907\uff0c\u5c31\u5fc5\u987b\u52a0\u5feb\u5c06\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u7eb3\u5165\u5168\u7403\u536b\u751f\u754c\u7684\u505a\u6cd5\u3002\u201d<\/p>\n

COVID-19 \u75ab\u60c5\u51f8\u663e\u4e86\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u7684\u4ef7\u503c\uff0c\u540c\u65f6\u4e5f\u9700\u8981\u79ef\u6781\u4e3b\u52a8\u7684\u4f20\u67d3\u75c5\u76d1\u6d4b\uff0c\u4ee5\u4fbf\u5728\u65b0\u53d1\u75be\u75c5\u8513\u5ef6\u5168\u7403\u4e4b\u524d\u53ca\u65f6\u53d1\u73b0\u3002\u5fc5\u987b\u6295\u5165\u9002\u5f53\u7684\u8d44\u6e90\u5e76\u5efa\u7acb\u76d1\u6d4b\u57fa\u7840\u8bbe\u65bd\uff0c\u4ee5\u786e\u4fdd\u6211\u4eec\u4e3a\u4e0b\u4e00\u6b21\u7684\u75ab\u60c5\u5a01\u80c1\u505a\u597d\u66f4\u5145\u5206\u7684\u51c6\u5907\u3002<\/p>\n

\u57fa\u56e0\u7ec4\u76d1\u6d4b\u4e0e\u6d41\u884c\u75c5\u5b66\u53ea\u662f\u5b9e\u9a8c\u5ba4\u8bca\u65ad\u5982\u4f55\u4e3a COVID-19 \u7ba1\u7406\u63d0\u4f9b\u652f\u6301\u7684\u4e00\u4e2a\u793a\u4f8b\u3002\u5982\u9700\u4e86\u89e3\u66f4\u591a\u5173\u4e8e\u5404\u79cd\u673a\u4f1a\u7684\u4fe1\u606f\uff0c\u8bf7\u67e5\u770b Asia Pacific Medical Technology Association (APACMed) \u65b0\u53d1\u5e03\u7684\u62a5\u544a\u300a\u8bca\u65ad\u5728 COVID-19 \u7ba1\u7406\u4e2d\u7684\u5173\u952e\u4f5c\u7528\u300b<\/a>\u3002\u00a0<\/em><\/p>\n

\u53c2\u8003\u6587\u732e\uff1a<\/em><\/p>\n

[1]<\/a> GISAID Database<\/p>\n

[2]<\/a> Sequencing COVID-19 at the Sanger Institute, The Sanger Institute Blog<\/p>\n

[3]<\/a> The Critical Role of Diagnostics in COVID-19 management, APACMed<\/p>\n

[4]<\/a> Genomic epidemiology of novel coronavirus – Asia-focused subsampling, Nextstrain<\/p>\n

[5]<\/a> “Coronavirus: India hunts for new strains as Covid wave looms”, BBC<\/p>\n

[6]<\/a> “Indonesia ramps up efforts to spot elusive COVID variants”, Nikkei Asia<\/p>\n

[7]<\/a> “The most worrying mutations in\u00a0five emerging coronavirus variants”, Scientific American<\/p>\n

[8]<\/a> “‘An accelerated cauldron of evolution’: Covid-19 patients with cancer, HIV, may play a role in emergence of variants”, The Washington Post<\/p>\n

[9]<\/a> “Tracking COVID-19 with wasterwater”, Nature Biotechnology<\/p>\n

[10]<\/a> MetaSUB consortium<\/p>\n

[11]<\/a> World Health Organisation Guidelines on Genomic Sequencing of SARS-CoV-2<\/p>\n

\n","protected":false},"excerpt":{"rendered":"

\u7b80\u4ecb\u2014\u2014COVID19 \u4e0b\u4e00\u4ee3\u6d4b\u5e8f\u5de5\u5177 \u7531\u4e8e\u51a0\u72b6\u75c5\u6bd2 NGS \u7684\u53ef\u7528\u6027\u4e0e\u53ef\u8d1f\u62c5\u6027\uff0c\u4e0b\u4e00\u4ee3\u6d4b\u5e8f (NGS) \u5de5\u5177\u5df2\u6210\u4e3a\u79d1\u5b66\u754c\u5e94\u5bf9 COVID-19 \u75ab\u60c5\u7684\u5fc5\u5907\u7ec4\u6210\u90e8\u5206\u3002\u57fa\u4e8e\u75c5\u6bd2\u57fa\u56e0\u7ec4\u5e8f\u5217\uff0c\u57fa\u56e0\u7ec4\u6570\u636e\u5b9e\u73b0\u4e86\u5bf9\u75c5\u539f\u4f53\u524d\u6240\u672a\u6709\u7684\u76d1\u6d4b\uff0c\u5e76\u63a8\u52a8\u4e86\u8bca\u65ad\u68c0\u6d4b\u4e0e\u75ab\u82d7\u7684\u5feb\u901f\u5f00\u53d1\u3002 \u9488\u5bf9\u6025\u6027\u91cd\u75c7\u547c\u5438\u7efc\u5408\u5f81\u51a0\u72b6\u75c5\u6bd2 2 (SARS-CoV-2) \u57fa\u56e0\u7ec4\u7684\u7b2c\u4e00\u6279\u7814\u7a76\u6765\u81ea\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u4e0a\u6d77\u5e02\u516c\u5171\u536b\u751f\u4e34\u5e8a\u4e2d\u5fc3\u7684\u79d1\u5b66\u5bb6\u3002Yong-Zhen Zhang \u6559\u6388\u7387\u9886\u7684\u56e2\u961f\u5bf9 2019 \u5e74 12 \u6708 26 \u65e5\u4ece\u6b66\u6c49\u4e00\u540d\u60a3\u8005\u8eab\u4e0a\u91c7\u96c6\u7684\u5206\u79bb\u7269\u8fdb\u884c\u4e86\u6d4b\u5e8f\uff1b\u4ed6\u4eec\u4e8e 2020 \u5e74 1 \u6708 5 \u65e5\u5b8c\u6210\u4e86\u57fa\u56e0\u7ec4\u7ec4\u88c5\u3002 \u8be5\u56e2\u961f\u5c06\u8be5\u57fa\u56e0\u7ec4\u5e8f\u5217\u5171\u4eab\u7ed9\u4e86\u957f\u671f\u7814\u7a76\u4f19\u4f34\u2014\u2014University of Sydney \u7684\u75c5\u6bd2\u5b66\u5bb6 Eddie Holmes \u6559\u6388\u3002\u4ed6\u4e8e 1 \u6708 11 \u65e5\u5c06\u5e8f\u5217\u4e0a\u4f20\u81f3\u516c\u5171\u6570\u636e\u5e93\uff0c\u5411\u5168\u4e16\u754c\u4ecb\u7ecd\u4e86\u8be5\u6709\u673a\u4f53\u7684\u57fa\u56e0\u7ec4\u3002 \u8be5\u5e8f\u5217\u6570\u636e\u7acb\u5373\u88ab\u90e8\u7f72\u7528\u4e8e\u75ab\u82d7\u5f00\u53d1\u5de5\u4f5c\uff0c\u4e3a\u968f\u540e\u9996\u6279\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e4b\u5916\u6295\u5165\u4f7f\u7528\u7684\u4e24\u79cd mRNA \u75ab\u82d7\u5960\u5b9a\u4e86\u57fa\u7840\u3002\u8be5\u6570\u636e\u4e5f\u662f\u4eca\u5929\u4f7f\u7528\u7684\u8bb8\u591a\u6025\u6027\u91cd\u75c7\u547c\u5438\u7efc\u5408\u5f81\u51a0\u72b6\u75c5\u6bd2 2 (SARS-CoV-2) \u8bca\u65ad\u68c0\u6d4b\u7684\u57fa\u7840\u3002 \u4f46\u6d4b\u5e8f\u5de5\u4f5c\u5e76\u672a\u5c31\u6b64\u505c\u6b62\u3002\u5230 2021 \u5e74\u521d\uff0c\u5df2\u5bf9 60 \u591a\u4e07\u4e2a\u75c5\u6bd2\u57fa\u56e0\u7ec4\u8fdb\u884c\u6d4b\u5e8f\uff0c\u5e76\u5728 GISAID \u6570\u636e\u5e93\u4e2d\u516c\u5f00\u5171\u4eab [1]\u3002\u5728\u5982\u6b64\u77ed\u7684\u65f6\u95f4\u5185\u751f\u6210\u7684\u57fa\u56e0\u7ec4\u5e8f\u5217\u6570\u91cf\uff0c\u8d85\u8fc7\u4e86\u9488\u5bf9\u4efb\u4f55\u5176\u4ed6\u75c5\u539f\u4f53\u6240\u4ea7\u751f\u7684\u603b\u91cf\u3002\u8fd9\u4e00\u5b9d\u8d35\u7684\u6570\u636e\u96c6\u4f7f\u79d1\u5b66\u5bb6\u80fd\u591f\u8ffd\u8e2a\u75c5\u6bd2\u4f20\u64ad\u8def\u5f84\u3001\u901a\u8fc7\u7cfb\u7edf\u53d1\u80b2\u6570\u636e\u7ed8\u5236\u4f20\u64ad\u56fe\u8c31\u3001\u6d4b\u7b97\u75c5\u6bd2\u53d8\u5f02\u901f\u7387\u3001\u53d1\u73b0\u65b0\u51fa\u73b0\u4e14\u503c\u5f97\u5173\u6ce8\u7684\u53d8\u5f02\u682a\uff0c\u5e76\u8bc6\u522b\u8d85\u7ea7\u4f20\u64ad\u4e8b\u4ef6\u3002 \u5982\u679c\u6ca1\u6709\u4ece\u5982\u6b64\u591a\u7684\u5206\u79bb\u682a\u4e2d\u751f\u6210\u7684\u5168\u57fa\u56e0\u7ec4\u5e8f\u5217\u6570\u636e\uff0c\u8fd9\u4e9b\u6210\u679c\u6839\u672c\u65e0\u6cd5\u5b9e\u73b0\u3002\u5728\u7f8e\u56fd\u548c\u82f1\u56fd\u7b49\u56fd\u5bb6\/\u5730\u533a\uff0c\u5b9e\u9a8c\u5ba4\u5df2\u7ecf\u5efa\u7acb\u4e86\u6d4b\u5e8f\u5de5\u4f5c\u6d41\u7a0b [2]\uff0c\u65e8\u5728\u5bb9\u7eb3\u8fd0\u884c\u5206\u5b50\u8bca\u65ad\u68c0\u6d4b\u540e\u9057\u7559\u7684\u5c11\u91cf\u6b8b\u7559\u6837\u672c\u3002\u5c3d\u7ba1\u8fd9\u573a\u75ab\u60c5\u582a\u79f0\u6bc1\u706d\u6027\uff0c\u4f46\u6765\u81ea\u5168\u7403\u5b9e\u9a8c\u5ba4\u7684 NGS 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