{"id":145586,"date":"2024-02-21T09:10:17","date_gmt":"2024-02-21T09:10:17","guid":{"rendered":"https:\/\/labinsights.com\/acf_article\/%e7%94%9f%e7%89%a9%e6%a0%87%e5%bf%97%e7%89%a9%e5%9c%a8%e8%84%93%e6%af%92%e7%97%87%e6%b2%bb%e7%96%97%e4%b8%ad%e7%9a%84%e4%bd%9c%e7%94%a8\/"},"modified":"2026-01-21T12:13:15","modified_gmt":"2026-01-21T12:13:15","slug":"the-role-of-biomarkers-in-management-of-sepsis","status":"publish","type":"acf_article","link":"https:\/\/labinsights.com\/zhcn\/disease-area\/sepsis\/the-role-of-biomarkers-in-management-of-sepsis\/","title":{"rendered":"\u751f\u7269\u6807\u5fd7\u7269\u5728\u8113\u6bd2\u75c7\u6cbb\u7597\u4e2d\u7684\u4f5c\u7528"},"content":{"rendered":"

\u300a\u7b2c\u4e09\u7248\u8113\u6bd2\u75c7\u4e0e\u611f\u67d3\u6027\u4f11\u514b\u5b9a\u4e49\u56fd\u9645\u5171\u8bc6<\/a>\u300b\uff08\u8113\u6bd2\u75c7-3\uff09\u5c06\u8113\u6bd2\u75c7\u5b9a\u4e49\u4e3a\uff1a\u201c\u7531\u5bbf\u4e3b\u5bf9\u611f\u67d3\u7684\u53cd\u5e94\u5931\u8c03\u6240\u81f4\u7684\u5371\u53ca\u751f\u547d\u7684\u5668\u5b98\u529f\u80fd\u969c\u788d\u201d\u3002 <\/p>\n

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\u964d\u9499\u7d20\u539f\u5728\u8113\u6bd2\u75c7\u6cbb\u7597\u4e2d\u7684\u4f5c\u7528<\/h2>\n

\u5bf9\u4e8e\u91cd\u75c7\u611f\u67d3\u548c\u8113\u6bd2\u75c7\u7684\u5371\u91cd\u60a3\u8005\u7684\u4e34\u5e8a\u7ba1\u7406\uff0c\u53ef\u4ee5\u901a\u8fc7\u7f29\u77ed\u8bca\u65ad\u548c\u6cbb\u7597\u51b3\u7b56\u7684\u65f6\u95f4\uff08\u5373\u533a\u5206\u7ec6\u83cc\u6027\u4e0e\u75c5\u6bd2\u6027\u4e0e\u771f\u83cc\u6027\u611f\u67d3\u4ee5\u53ca\u975e\u611f\u67d3\u6027\u75c5\u56e0\uff09\u6765\u6539\u5584\u3002\u6b64\u5916\uff0c\u901a\u8fc7\u65e9\u671f\u8fdb\u884c\u98ce\u9669\u5206\u5c42\u5e76\u63d0\u4f9b\u9884\u540e\u4fe1\u606f\uff0c\u8fd8\u53ef\u4ee5\u4f18\u5316\u60a3\u8005\u7684\u6536\u6cbb\u5730\u70b9\u51b3\u7b56\uff08\u4f8b\u5982\uff0c\u51b3\u5b9a\u662f\u5426\u63d0\u524d\u51fa\u9662\u6216\u5347\u7ea7\u6cbb\u7597\uff09\u91cd\u590d\u6d4b\u5b9a\u751f\u7269\u6807\u5fd7\u7269\u8fd8\u6709\u52a9\u4e8e\u901a\u8fc7\u76d1\u6d4b\u60a3\u8005\u75c5\u60c5\uff0c\u6839\u636e\u4e2a\u4f53\u5316\u9700\u6c42\u8c03\u6574\u6cbb\u7597\u65b9\u6848\uff08\u6297\u83cc\u836f\u7269\u7ba1\u7406\uff09\u3002\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u5bbf\u4e3b\u5e94\u7b54\u548c\u8840\u6db2\u611f\u67d3\u6807\u5fd7\u7269\u964d\u9499\u7d20\u539f (PCT) \u7684\u4f7f\u7528\u5df2\u5f97\u5230\u5f88\u591a\u5173\u6ce8\uff0c\u5e76\u4e14\u5df2\u7ecf\u88ab\u6279\u51c6\u7528\u4e8e\u6307\u5bfc\u547c\u5438\u9053\u611f\u67d3\u548c\u8113\u6bd2\u75c7\u60a3\u8005\u7684\u6297\u5fae\u751f\u7269\u7597\u6cd5\u3002PCT \u662f\u964d\u9499\u7d20\u7684\u524d\u4f53\u6fc0\u7d20\uff0c\u5728\u5065\u5eb7\u4e2a\u4f53\u4e2d\u68c0\u6d4b\u4e0d\u5230\u3002\u7136\u800c\uff0c\u5728\u7ec6\u83cc\u611f\u67d3\u65f6\uff0cPCT \u7684\u4ea7\u751f\u4f1a\u4e0a\u8c03\uff0c\u5e76\u5728\u6062\u590d\u671f\u8fc5\u901f\u4e0b\u964d\u3002\u56e0\u6b64\uff0cPCT \u63d0\u4f9b\u4e86\u91cd\u8981\u7684\u9644\u52a0\u4fe1\u606f\uff0c\u7528\u4ee5\u8865\u5145\u4e34\u5e8a\u53ca\u5176\u4ed6\u8bca\u65ad\u53c2\u6570\u3002\u53cd\u4e4b\uff0c\u8fd9\u4e0d\u4ec5\u5bf9\u5173\u4e8e\u6cbb\u7597\u7591\u4f3c\u611f\u67d3\u6216\u8113\u6bd2\u75c7\u60a3\u8005\u7684\u51b3\u7b56\u5177\u6709\u91cd\u5927\u5f71\u54cd\uff0c\u800c\u4e14\u8fd8\u53ef\u4ee5\u5f71\u54cd\u6297\u751f\u7d20\u6cbb\u7597\u7597\u7a0b\u7684\u957f\u77ed\u3002\u5728\u8113\u6bd2\u75c7\u6cbb\u7597\u4e2d\uff0cPCT \u7684\u5e94\u7528\u4e0d\u65ad\u62d3\u5c55\uff0c\u591a\u9879\u5e72\u9884\u6027\u7814\u7a76\u548c\u7cfb\u7edf\u7efc\u8ff0\u5df2\u5206\u6790\u5e76\u603b\u7ed3\u4e86 PCT \u6307\u5bfc\u7b56\u7565\u5bf9\u6297\u751f\u7d20\u4f7f\u7528\u53ca\u5065\u5eb7\u7ed3\u5c40\u7684\u5f71\u54cd\u3002\u7136\u800c\uff0c\u5bf9\u4e8e PCT \u5728\u8113\u6bd2\u75c7\u6cbb\u7597\u4e2d\u7684\u6700\u4f73\u5e94\u7528\u65b9\u5f0f\uff0c\u5c1a\u672a\u8fbe\u6210\u666e\u904d\u5171\u8bc6\u3002<\/p>\n

\u5728\u5065\u5eb7\u4e2a\u4f53\u4e2d\uff0c\u7531\u4e8e\u5728\u65e0\u5168\u8eab\u6027\u708e\u75c7\u65f6\u8be5\u86cb\u767d\u4e0d\u4f1a\u91ca\u653e\u5230\u8840\u6db2\u4e2d\uff0c\u56e0\u6b64\u8840\u6e05 PCT \u901a\u5e38\u68c0\u6d4b\u4e0d\u5230\u3002\u7136\u800c\uff0c\u5728\u7531\u7ec6\u83cc\u611f\u67d3\u5f15\u8d77\u7684\u8113\u6bd2\u75c7\u7684\u60c5\u51b5\u4e0b\uff0c\u51e0\u4e4e\u6240\u6709\u7ec4\u7ec7\u90fd\u4f1a\u88ab\u8bf1\u5bfc\u5408\u6210 PCT\uff0c\u56e0\u6b64\u5728\u8840\u6db2\u4e2d\u5373\u53ef\u68c0\u6d4b\u5230\u3002PCT \u7684\u5408\u6210\u53ef\u88ab\u7ec6\u83cc\u6bd2\u7d20\uff08\u4f8b\u5982\u5185\u6bd2\u7d20\uff09\u4ee5\u53ca\u7ec6\u80de\u56e0\u5b50\uff08\u4f8b\u5982\u767d\u4ecb\u7d20 (IL)-1\u03b2\u3001\u767d\u4ecb\u7d20-6\u548c\u80bf\u7624\u574f\u6b7b\u56e0\u5b50 (TNF)-\u03b1\uff09\u6240\u89e6\u53d1\u3002 \u7531\u4e8e\u75c5\u6bd2\u611f\u67d3\u8fc7\u7a0b\u4e2d\u91ca\u653e\u7684\u67d0\u4e9b\u7ec6\u80de\u56e0\u5b50\u4f1a\u6291\u5236 TNF-\u03b1 \u7684\u4ea7\u751f\uff0c\u56e0\u6b64 PCT \u5408\u6210\u901a\u5e38\u4e0d\u4f1a\u5728\u5927\u591a\u6570\u75c5\u6bd2\u611f\u67d3\u4e2d\u8bf1\u5bfc\u3002\u6b64\u5916\uff0cPCT \u7684\u751f\u7269\u5b66\u6ce2\u52a8\u8303\u56f4\u8f83\u5927\uff0c\u5728\u7ec6\u83cc\u523a\u6fc0\u540e\u8bf1\u5bfc\u65f6\u95f4\u77ed\u4e14\u534a\u8870\u671f\u8f83\u957f\u3002\u56e0\u6b64\uff0cPCT \u5728\u9274\u522b\u7ec6\u83cc\u6027\u4e0e\u75c5\u6bd2\u6027\u708e\u75c7\u65b9\u9762\u5177\u6709\u826f\u597d\u7684\u533a\u5206\u80fd\u529b\uff0c\u4e14\u68c0\u6d4b\u7ed3\u679c\u53ef\u8fc5\u901f\u83b7\u5f97\u3002PCT\u672c\u8eab\u65e0\u6cd5\u5206\u79bb\u6216\u76f4\u63a5\u68c0\u6d4b\u7279\u5b9a\u75c5\u539f\u4f53\uff0c\u4f46\u5176\u6c34\u5e73\u6709\u52a9\u4e8e\u4f30\u8ba1\u53d1\u751f\u4e25\u91cd\u7ec6\u83cc\u611f\u67d3\u7684\u53ef\u80fd\u6027\u3002<\/p>\n

\u5c3d\u7ba1\u7ecf\u8fc7\u6570\u5341\u5e74\u7684\u7814\u7a76\u52aa\u529b\uff0c\u4f46\u4ecd\u7136\u6ca1\u6709\u53ef\u7528\u7684\u8113\u6bd2\u75c7\u7279\u5f02\u6027\u6cbb\u7597\u9009\u62e9\u3002\u8981\u5b9e\u73b0\u6210\u529f\u6cbb\u7597\u5e76\u83b7\u5f97\u79ef\u6781\u7ed3\u5c40\uff0c\u5173\u952e\u5728\u4e8e\u53ca\u65e9\u8bca\u65ad\u5e76\u4e0e\u975e\u611f\u67d3\u6027\u75c5\u56e0\u52a0\u4ee5\u9274\u522b\uff0c\u4ece\u800c\u8fc5\u901f\u542f\u52a8\u6297\u611f\u67d3\u6cbb\u7597\u548c\u6db2\u4f53\u590d\u82cf\u3002\u7136\u800c\uff0c\u7531\u4e8e\u786e\u8bca\u6216\u7591\u4f3c\u8113\u6bd2\u75c7\u7684\u4e34\u5e8a\u4f53\u5f81\u4e3a\u5f02\u8d28\u6027\u4e14\u5f80\u5f80\u590d\u6742\u591a\u6837\uff0c\u5176\u8bca\u65ad\u548c\u6cbb\u7597\u4ecd\u7136\u5145\u6ee1\u6311\u6218\u3002\u8fc4\u4eca\u4e3a\u6b62\uff0c\u5c1a\u65e0\u7528\u4e8e\u68c0\u6d4b\u7531\u8840\u6d41\u611f\u67d3\u5f15\u8d77\u7684\u8113\u6bd2\u75c7\u7684\u91d1\u6807\u51c6\u3002\u5728\u4e34\u5e8a\u7591\u4f3c\u611f\u67d3\u6216\u8113\u6bd2\u75c7\u7684\u60a3\u8005\u4e2d\uff0c\u5e38\u89c4\u8bca\u65ad\u65b9\u6cd5\uff08\u4f8b\u5982\u8840\u57f9\u517b\u4ee5\u53ca\u708e\u75c7\u6027\u8840\u6db2\u6807\u5fd7\u7269 C \u53cd\u5e94\u86cb\u767d (CRP)\u3001\u767d\u7ec6\u80de\u8ba1\u6570 (WBC)\uff09\u5747\u5b58\u5728\u4e00\u5b9a\u7684\u5c40\u9650\u6027\u3002\u901a\u8fc7\u8840\u57f9\u517b\u9274\u5b9a\u75c5\u539f\u4f53\uff0c\u53ef\u4ee5\u83b7\u5f97\u6709\u5173\u5fae\u751f\u7269\u79cd\u7c7b\u53ca\u5176\u5bf9\u6297\u751f\u7d20\u6cbb\u7597\u654f\u611f\u6027\u7684\u4fe1\u606f\u3002\u7136\u800c\uff0c\u53ea\u6709\u5c11\u6570\u9001\u68c0\u7684\u8840\u57f9\u517b\u7ed3\u679c\u5448\u9633\u6027\u3002\u5728\u7ea6 40%\u201390% \u88ab\u8ba4\u4e3a\u5b58\u5728\u5168\u8eab\u6027\u611f\u67d3\u7684\u60a3\u8005\u4e2d\uff0c\u8840\u57f9\u517b\u7ed3\u679c\u4e3a\u9634\u6027\uff0c\u672a\u68c0\u51fa\u75c5\u539f\u4f53\u751f\u957f\u3002\u6b64\u5916\uff0c\u7ed3\u679c\u83b7\u53d6\u65f6\u95f4\u8f83\u957f\u9650\u5236\u4e86\u521d\u59cb\u6cbb\u7597\u51b3\u7b56\u7684\u5236\u5b9a\uff0c\u800c\u6c61\u67d3\u5219\u4f1a\u964d\u4f4e\u6240\u83b7\u7ed3\u679c\u7684\u7279\u5f02\u6027\u3002\u4e3a\u4e86\u6539\u5584\u8bca\u65ad\u68c0\u67e5\uff0c\u9700\u8981\u8fdb\u884c\u989d\u5916\u7684\u68c0\u67e5\uff0c\u4ee5\u4fbf\u5c3d\u65e9\u505a\u51fa\u53ef\u9760\u7684\u8bca\u65ad [3]\u3002<\/p>\n

IL-6 \u53ca\u5176\u5728\u65b0\u751f\u5a74\u513f\u8113\u6bd2\u75c7\u4e2d\u7684\u4f5c\u7528<\/h2>\n

\u65b0\u751f\u5a74\u513f\u8113\u6bd2\u75c7\u5360\u5168\u7403\u5168\u90e8\u4f24\u6b8b\u8c03\u6574\u751f\u547d\u5e74\u7684 0.97%\uff0c\u5176\u6bd4\u4f8b\u9ad8\u4e8e\u7ed3\u76f4\u80a0\u764c\u3001\u54ee\u5598\u6216\u4e73\u817a\u764c\u3002\u65b0\u751f\u513f\u8113\u6bd2\u75c7\u6b7b\u4ea1\u7387\u9ad8\uff0c\u4e3a11-19%2\uff0c\u5e76\u4e14\u4e0e\u8111\u635f\u4f24\u4ee5\u53ca\u5e7c\u513f\u671f\u4e0d\u826f\u7684\u795e\u7ecf\u53d1\u80b2\u548c\u751f\u957f\u7ed3\u5c40\u76f8\u5173\u8054\u3002\u8fd9\u4e9b\u4e0d\u826f\u7ed3\u5c40\u51f8\u663e\u4e86\u65e9\u671f\u8bc6\u522b\u548c\u8fc5\u901f\u5e72\u9884\u7684\u5fc5\u8981\u6027\u3002\u7531\u4e8e\u8113\u6bd2\u75c7\u662f\u5bf9\u611f\u67d3\u7684\u5168\u8eab\u708e\u75c7\u53cd\u5e94\uff0c\u56e0\u6b64\u4ece\u8840\u6db2\u4e2d\u5206\u79bb\u7ec6\u83cc\u88ab\u8ba4\u4e3a\u662f\u91d1\u6807\u51c6\u3002\u7531\u4e8e\u6781\u4f4e\u51fa\u751f\u4f53\u91cd\u5a74\u513f\uff08VLBW \u5a74\u513f\uff0c\u51fa\u751f\u4f53\u91cd < 1500 gm\uff09\u7684\u53ef\u91c7\u8840\u5bb9\u91cf\u4ec5\u7ea6 0.5\u20131 mL\uff0c\u4e14\u4f4e\u83cc\u91cf\u83cc\u8840\u75c7\u53d1\u751f\u7387\u9ad8\u3001\u8840\u57f9\u517b\u8f6c\u4e3a\u9633\u6027\u6240\u9700\u65f6\u95f4\u8f83\u957f\uff0c\u56e0\u6b64\u4eba\u4eec\u8bc4\u4f30\u4e86\u591a\u79cd\u6307\u6807\u5728\u8bca\u65ad\u65b0\u751f\u513f\u8113\u6bd2\u75c7\u65b9\u9762\u7684\u51c6\u786e\u6027\uff0c\u5305\u62ec\u964d\u9499\u7d20\u539f\u3001\u8102\u591a\u7cd6\u7ed3\u5408\u86cb\u767d\u3001Presepsin \u4ee5\u53ca\u767d\u4ecb\u7d20-6\u3002<\/p>\n

IL-6 \u662f\u4e00\u79cd\u53c2\u4e0e\u514d\u75ab\u5e94\u7b54\u3001\u9020\u8840\u548c\u6025\u6027\u671f\u53cd\u5e94\u7684\u591a\u529f\u80fd\u7ec6\u80de\u56e0\u5b50\u3002\u5728\u5e94\u5bf9\u611f\u67d3\u65f6\uff0cIL-6 \u53ef\u4fc3\u8fdb IgM\u3001IgG \u548c IgA \u7684\u4ea7\u751f\u4ee5\u53ca\u8f85\u52a9\u6027 T \u7ec6\u80de\u7684\u589e\u6b96\uff0c\u4ece\u800c\u5728\u5bbf\u4e3b\u9632\u5fa1\u673a\u5236\u4e2d\u53d1\u6325\u5173\u952e\u4f5c\u7528\u3002\u66b4\u9732\u4e8e\u7ec6\u83cc\u5185\u6bd2\u7d20\u540e\uff0cIL-6 \u6d53\u5ea6\u5148\u4e8e C \u53cd\u5e94\u86cb\u767d (CRP) \u7b49\u6025\u6027\u671f\u53cd\u5e94\u7269\u8d28\u5347\u9ad8\u3002\u53ef\u5728\u8110\u5e26\u8840\u6216\u8840\u6e05\u4e2d\u6d4b\u5b9a IL-6\uff0c\u4e24\u8005\u7684\u8bca\u65ad\u51c6\u786e\u6027\u6709\u6240\u4e0d\u540c\u3002\u8110\u5e26\u8840 IL-6 \u5bf9\u65e9\u53d1\u578b\u8113\u6bd2\u75c7\u7684\u654f\u611f\u6027\u4e3a 87%\u2013100%\u3002\u8840\u6e05 IL-6 \u5728\u8bca\u65ad\u65e9\u53d1\u578b\u8113\u6bd2\u75c7\u65f6\u7684\u654f\u611f\u6027\u4e3a 75%\u201385%\uff0c\u7279\u5f02\u6027\u4e3a 72.8%\u201388%\uff1b\u5728\u8bca\u65ad\u665a\u53d1\u578b\u8113\u6bd2\u75c7\u65f6\u7684\u654f\u611f\u6027\u4e3a 80%\u201393.8%\uff0c\u7279\u5f02\u6027\u4e3a 80%\u201396%\uff0c\u5176\u8bca\u65ad\u6027\u80fd\u4f18\u4e8e CRP\u3002\u5728\u6297\u751f\u7d20\u6cbb\u7597\u671f\u95f4\uff0c\u8840\u6e05 IL-6 \u6d53\u5ea6\u8fc5\u901f\u964d\u81f3\u65e0\u6cd5\u68c0\u6d4b\u6c34\u5e73\u3002\u7531\u4e8e IL-6 \u5177\u6709\u9ad8\u654f\u611f\u6027\u548c\u9634\u6027\u9884\u6d4b\u503c\uff0c\u4e0e\u9ad8\u7279\u5f02\u6027\u7684 CRP \u8054\u5408\u5e94\u7528\u65f6\uff0c\u53ef\u4f5c\u4e3a\u8bca\u65ad\u65b0\u751f\u513f\u8113\u6bd2\u75c7\u7684\u7406\u60f3\u5b9e\u9a8c\u5ba4\u6307\u6807\u4e4b\u4e00\u3002<\/p>\n

\"\" <\/p>\n

\u56fe 1\uff1a\u5728\u8113\u6bd2\u75c7\u4e2d\uff0c\u767d\u4ecb\u7d20-6 \u548c C \u53cd\u5e94\u86cb\u767d\u53ca\u5176\u968f\u65f6\u95f4\u7684\u53d1\u5c55\u3002\u57f9\u517b\u786e\u8bca\u7684\u8113\u6bd2\u75c7\u60a3\u513f\u5728\u751f\u540e\u7b2c 1 \u5929 (a) \u53ca\u751f\u540e\u7b2c 7 \u5929\u4ee5\u540e (b) \u7684\u8840\u6e05\u767d\u4ecb\u7d20-6 \u548c C \u53cd\u5e94\u86cb\u767d (CRP) \u6c34\u5e73\u3002<\/em><\/p>\n

\u5982\u56fe 1 \u6240\u793a\uff0c\u5728 DOL 1\uff08\u751f\u540e\u7b2c 1 \u5929\uff09\u57f9\u517b\u786e\u8bca\u7684\u8113\u6bd2\u75c7\u75c5\u4f8b\u4e2d\uff0c\u8840\u6e05 IL-6 \u5373\u5448\u663e\u8457\u5347\u9ad8\uff0c\u800c CRP \u9700\u7ea6 48 \u5c0f\u65f6\u624d\u8fbe\u5230\u5cf0\u503c\u3002\u57fa\u4e8e\u8840\u6e05 IL-6 \u7684\u9ad8\u51c6\u786e\u5ea6\uff0c\u6211\u4eec\u5f97\u51fa\u7ed3\u8bba\uff0c\u5728 DOL 1 \u6d4b\u5b9a IL-6 \u5bf9\u5148\u5929\u6027\u8113\u6bd2\u75c7\u7684\u8bca\u65ad\u975e\u5e38\u6709\u5e2e\u52a9\u3002\u540c\u6837\u5982\u56fe 1 \u6240\u793a\uff0c\u5728 DOL 7 \u540e\u7684\u57f9\u517b\u786e\u8bca\u8113\u6bd2\u75c7\u53d1\u4f5c\u4e2d\uff0c\u8840\u6e05 IL-6 \u8f83 CRP \u63d0\u524d 24\u201348 \u5c0f\u65f6\u5347\u9ad8\u3002\u56e0\u6b64\uff0c\u5728\u751f\u540e\u7b2c\u4e00\u5468\u4e4b\u540e\u53d1\u751f\u7684\u8113\u6bd2\u75c7\u4e2d\uff0c\u8840\u6e05 IL-6 \u6210\u4e3a\u6700\u65e9\u5347\u9ad8\u4e14\u8bca\u65ad\u51c6\u786e\u6027\u6700\u9ad8\u7684\u5b9e\u9a8c\u5ba4\u6307\u6807\u3002Tzialla \u7b49\u4eba\u62a5\u9053\uff0c\u7ec6\u80de\u56e0\u5b50\u6c34\u5e73\u53d8\u5316\u5341\u5206\u8fc5\u901f\uff0c\u751a\u81f3\u65e9\u4e8e\u6025\u6027\u671f\u53cd\u5e94\u7269\u3002<\/p>\n

\u57fa\u4e8e\u8840\u6e05 IL-6 \u7684\u9ad8\u51c6\u786e\u5ea6\uff0c\u5c24\u5176\u662f\u6781\u9ad8\u7684\u9634\u6027\u9884\u6d4b\u503c\uff0c\u6211\u4eec\u5f97\u51fa\u7ed3\u8bba\uff0c\u8840\u6e05 IL-6 \u5728\u65b0\u751f\u513f\u548c\u65e9\u4ea7\u513f\u8113\u6bd2\u75c7\u7684\u8bca\u65ad\u4e2d\u975e\u5e38\u6709\u7528\u3002\u6b64\u5916\uff0c\u5728\u5f00\u59cb\u6709\u6548\u7684\u6297\u751f\u7d20\u6cbb\u7597\u540e\uff0cIL-6 \u4f1a\u8fc5\u901f\u4e0b\u964d\uff0c\u4ece\u800c\u53ef\u4ee5\u5feb\u901f\u76d1\u6d4b\u6297\u751f\u7d20\u6cbb\u7597\uff0c\u5e76\u53ca\u65f6\u4e0a\u8c03\u6216\u4e0b\u8c03\u6cbb\u7597\u5f3a\u5ea6 [4]\u3002<\/p>\n

\u7ed3\u8bba<\/h2>\n

\u8113\u6bd2\u75c7\u662f\u4e00\u79cd\u5371\u53ca\u751f\u547d\u7684\u75be\u75c5\uff0c\u5e76\u4e14\u662f ICU \u4f4f\u9662\u60a3\u8005\u7684\u6700\u5e38\u89c1\u539f\u56e0\u4e4b\u4e00\u3002\u65e9\u671f\u8bca\u65ad\u548c\u9002\u5f53\u7ba1\u7406\u5bf9\u4e8e\u964d\u4f4e\u8113\u6bd2\u75c7\u6b7b\u4ea1\u7387\u6781\u4e3a\u5fc5\u8981\u3002\u7136\u800c\uff0c\u4e2a\u4f53\u5bf9\u611f\u67d3\u7684\u751f\u7406\u53cd\u5e94\u5dee\u5f02\u5f88\u5927\uff0c\u5e76\u4e14\u8113\u6bd2\u75c7\u7684\u4f53\u5f81\u548c\u75c7\u72b6\u7f3a\u4e4f\u7279\u5f02\u6027\uff0c\u56e0\u6b64\u65e9\u671f\u8bca\u65ad\u8f83\u4e3a\u56f0\u96be\u3002\u56e0\u6b64\uff0c\u5df2\u7ecf\u7814\u7a76\u4e86\u8bb8\u591a\u7528\u4e8e\u8bca\u65ad\u8113\u6bd2\u75c7\u7684\u6f5c\u5728\u751f\u7269\u6807\u5fd7\u7269\u3002\u8fd9\u4e9b\u5206\u5b50\u4e3b\u8981\u53c2\u4e0e\u673a\u4f53\u5bf9\u611f\u67d3\u7684\u5148\u5929\u514d\u75ab\u5e94\u7b54\u7684\u521d\u59cb\u53d1\u75c5\u673a\u5236\uff0c\u5728\u8bb8\u591a\u60c5\u51b5\u4e0b\u517c\u5177\u9884\u540e\u4ef7\u503c\u548c\u8bca\u65ad\u4ef7\u503c\u3002\u8113\u6bd2\u75c7\u7684\u9884\u540e\u6807\u5fd7\u7269\u901a\u5e38\u4e0e\u8113\u6bd2\u75c7\u5f15\u8d77\u7684\u5668\u5b98\u529f\u80fd\u969c\u788d\u6709\u5173\uff0c\u76ee\u524d\u6b63\u5c1d\u8bd5\u5f00\u53d1\u4ee5\u8fd9\u4e9b\u9884\u540e\u751f\u7269\u6807\u5fd7\u7269\u4e3a\u9776\u70b9\u7684\u8113\u6bd2\u75c7\u6cbb\u7597\u836f\u7269\u3002\u6b64\u5916\uff0c\u8fd1\u6765\u7684\u6280\u672f\u8fdb\u6b65\u8fd8\u63a8\u52a8\u4e86\u5fae\u751f\u7269\u7ec4\u3001\u975e\u7f16\u7801 RNA \u7b49\u65b0\u578b\u751f\u7269\u6807\u5fd7\u7269\u7684\u5f00\u53d1\u3002\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u5728\u514d\u75ab\u7cfb\u7edf\u7684\u53d1\u80b2\u4e0e\u6210\u719f\u4ee5\u53ca\u673a\u4f53\u5bf9\u75c5\u539f\u4f53\u7684\u9632\u5fa1\u4e2d\u8d77\u7740\u91cd\u8981\u4f5c\u7528\u3002\u56e0\u6b64\uff0c\u80a0\u9053\u751f\u6001\u5931\u8c03\u88ab\u8ba4\u4e3a\u662f\u8113\u6bd2\u75c7\u7684\u53d1\u5c55\u548c\u8fdb\u5c55\u7684\u91cd\u8981\u751f\u7269\u6807\u5fd7\u7269\u3002miRNA \u548c\u957f\u975e\u7f16\u7801 RNA \u7b49\u975e\u7f16\u7801 RNA \u53ef\u901a\u8fc7\u591a\u79cd\u65b9\u5f0f\u8c03\u8282\u57fa\u56e0\u8868\u8fbe\uff0c\u4f46\u5b83\u4eec\u5728\u8113\u6bd2\u75c7\u53d1\u75c5\u4e2d\u7684\u5177\u4f53\u4f5c\u7528\u53ca\u5176\u673a\u5236\u5c1a\u672a\u5b8c\u5168\u9610\u660e\u3002<\/p>\n

\u82e5\u8981\u5728\u4e34\u5e8a\u4e0a\u5e94\u7528\u8fd9\u4e9b\u65b0\u751f\u7269\u6807\u5fd7\u7269\uff0c\u8fd8\u9700\u8fdb\u4e00\u6b65\u8bc4\u4f30\u5176\u5728\u8113\u6bd2\u75c7\u53d1\u75c5\u8fc7\u7a0b\u4e2d\u7684\u4f5c\u7528\uff0c\u5e76\u5efa\u7acb\u7528\u4e8e\u5176\u68c0\u6d4b\u4e0e\u5206\u6790\u7684\u6700\u4f73\u6807\u51c6\u5316\u7b56\u7565 [5]\u3002<\/p>\n

\u53c2\u8003\u6587\u732e\uff1a<\/em><\/p>\n

[1] <\/a>Sepsis Clinical Care Standard 2022<\/p>\n

[2]<\/a> Global Burden of Disease study<\/p>\n

[3]<\/a>\u00a0Gregoriano, C.et al. (2020) \u2018Role of procalcitonin use in the management of sepsis\u2019, Journal of Thoracic Disease, 12(S1). doi:10.21037\/jtd.2019.11.63.<\/p>\n

[4]<\/a>\u00a0K\u00fcng, E.et al. (2022) \u2018Cut-off values of serum interleukin-6 for culture-confirmed sepsis in neonates\u2019, Pediatric Research, 93(7), pp. 1969\u20131974. doi:10.1038\/s41390-022-02329-9.<\/p>\n

[5]<\/a>\u00a0Kim, M.-H. and Choi, J.-H. (2020) \u2018An update on sepsis biomarkers\u2019, Infection & Chemotherapy, 52(1), p. 1.doi:10.3947\/ic.2020.52.1.1.<\/p>\n

\n

\u672c\u6587\u6700\u521d\u53d1\u8868\u4e8eRoche Diagnostics \u6fb3\u5927\u5229\u4e9a<\/a>\u3002<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

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\u53d6\u6d88\u4e86\u201c\u4e25\u91cd\u8113\u6bd2\u75c7\u201d\u8fd9\u4e00\u672f\u8bed\uff0c\u6539\u4e3a\u5bf9\u201c\u611f\u67d3\u6027\u4f11\u514b\u201d\u548c\u201c\u8113\u6bd2\u75c7\u201d\u8fdb\u884c\u91cd\u65b0\u5b9a\u4e49\u548c\u5206\u5c42\uff0c\u4ee5\u671f\u4fc3\u8fdb\u5bf9\u8113\u6bd2\u75c7\u60a3\u8005\u7684\u66f4\u65e9\u8bc6\u522b\u548c\u66f4\u53ca\u65f6\u6cbb\u7597\u3002\u8113\u6bd2\u75c7\u7684\u4e25\u91cd\u7a0b\u5ea6\u5448\u8fde\u7eed\u8c31\u3002\u5c3d\u7ba1\u8bca\u65ad\u53ef\u80fd\u5b58\u5728\u4e0d\u786e\u5b9a\u6027\uff0c\u4f46\u8113\u6bd2\u75c7\u60a3\u8005\u90fd\u53ef\u80fd\u51fa\u73b0\u5feb\u901f\u4e14\u4e25\u91cd\u7684\u75c5\u60c5\u6076\u5316\uff0c\u56e0\u6b64\u53ea\u8981\u5b58\u5728\u8113\u6bd2\u75c7\u7684\u53ef\u80fd\u6027\uff0c\u5c31\u9700\u8981\u53ca\u65f6\u5e72\u9884 [1]\u3002 \u5168\u7403\u75be\u75c5\u8d1f\u62c5\u7814\u7a76\u4f7f\u7528\u6765\u81ea 195 \u4e2a\u56fd\u5bb6\u548c\u5730\u533a\u7684 1.09 \u4ebf\u4efd\u6b7b\u4ea1\u8bb0\u5f55\u548c 860 \u4e07\u4efd\u533b\u9662\u75c5\u6848\u8bb0\u5f55\uff0c\u6765\u4f30\u8ba1\u5168\u7403\u8113\u6bd2\u75c7\u7684\u75be\u75c5\u8d1f\u62c5\u3002\u7814\u7a76\u53d1\u73b0\uff0c2017 \u5e74\u5168\u7403\u6709 4900 \u4e07\u4f8b\u8113\u6bd2\u75c7\u75c5\u4f8b\u548c 1100 \u4e07\u4f8b\u6b7b\u4ea1\uff0c\u662f\u6b64\u524d\u4f30\u8ba1\u7684\u4e24\u500d\u3002\u591a\u8fbe\u5168\u7403\u6b7b\u4ea1\u4eba\u6570\u7684\u4e94\u5206\u4e4b\u4e00\u4e0e\u8113\u6bd2\u75c7\u76f8\u5173\u3002\u4ee4\u4eba\u62c5\u5fe7\u7684\u662f\uff0c\u5982\u6b64\u5927\u91cf\u7684\u751f\u547d\u6b63\u5728\u56e0\u4e00\u79cd\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u53ef\u4ee5\u9884\u9632\u7684\u75be\u75c5\u800c\u901d\u53bb\u3002\u8fc7\u53bb\u5bf9\u6fb3\u5927\u5229\u4e9a\u8113\u6bd2\u75c7\u8d1f\u62c5\u7684\u4f30\u8ba1\u4e3b\u8981\u57fa\u4e8e\u5728\u91cd\u75c7\u76d1\u62a4\u5ba4\u63a5\u53d7\u6cbb\u7597\u7684\u60a3\u8005\uff0c\u5f53\u65f6\u63a8\u7b97\u7684\u75c5\u4f8b\u6570\u4e3a 1.8 \u4e07\u4f8b\uff0c\u6b7b\u4ea1\u4e3a 5,000 \u4f8b\u3002 \u800c\u5168\u7403\u75be\u75c5\u8d1f\u62c5\u7814\u7a76\u7684\u6700\u65b0\u4f30\u8ba1\u5c06\u9662\u5916\u53d1\u751f\u7684\u8113\u6bd2\u75c7\u4e5f\u7eb3\u5165\u7edf\u8ba1\uff0c\u56e0\u6b64\u66f4\u51c6\u786e\u5730\u53cd\u6620\u4e86\u95ee\u9898\u7684\u7a0b\u5ea6\uff1a\u6fb3\u5927\u5229\u4e9a\u6bcf\u5e74\u6709 55,000 \u4f8b\u8113\u6bd2\u75c7\u75c5\u4f8b\u548c 8,700 \u4f8b\u6b7b\u4ea1\u3002 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(PCT) \u7684\u4f7f\u7528\u5df2\u5f97\u5230\u5f88\u591a\u5173\u6ce8\uff0c\u5e76\u4e14\u5df2\u7ecf\u88ab\u6279\u51c6\u7528\u4e8e\u6307\u5bfc\u547c\u5438\u9053\u611f\u67d3\u548c\u8113\u6bd2\u75c7\u60a3\u8005\u7684\u6297\u5fae\u751f\u7269\u7597\u6cd5\u3002PCT \u662f\u964d\u9499\u7d20\u7684\u524d\u4f53\u6fc0\u7d20\uff0c\u5728\u5065\u5eb7\u4e2a\u4f53\u4e2d\u68c0\u6d4b\u4e0d\u5230\u3002\u7136\u800c\uff0c\u5728\u7ec6\u83cc\u611f\u67d3\u65f6\uff0cPCT \u7684\u4ea7\u751f\u4f1a\u4e0a\u8c03\uff0c\u5e76\u5728\u6062\u590d\u671f\u8fc5\u901f\u4e0b\u964d\u3002\u56e0\u6b64\uff0cPCT 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