{"id":145673,"date":"2023-01-11T01:55:36","date_gmt":"2023-01-11T01:55:36","guid":{"rendered":"https:\/\/labinsights.com\/acf_article\/%e4%bd%8f%e9%99%a2%e6%82%a3%e8%80%85%e7%9a%84%e8%a1%80%e6%a0%93%e9%a3%8e%e9%99%a9%e4%b8%8e%e6%8a%97%e5%87%9d%e6%b2%bb%e7%96%97%ef%bc%9aalex-c-spyropoulos%e6%95%99%e6%8e%88%e7%9a%84%e8%a7%81%e8%a7%a3\/"},"modified":"2026-02-09T05:06:55","modified_gmt":"2026-02-09T05:06:55","slug":"thrombosis-risk-and-anticoagulation-in-hospitalised-patients-insights-from-prof-alex-c-spyropoulos","status":"publish","type":"acf_article","link":"https:\/\/labinsights.com\/zhcn\/disease-area\/covid-19\/thrombosis-risk-and-anticoagulation-in-hospitalised-patients-insights-from-prof-alex-c-spyropoulos\/","title":{"rendered":"\u4f4f\u9662\u60a3\u8005\u7684\u8840\u6813\u98ce\u9669\u4e0e\u6297\u51dd\u6cbb\u7597\uff1aAlex C Spyropoulos\u6559\u6388\u7684\u89c1\u89e3"},"content":{"rendered":"

\u57282022\u5e743\u6708\u7531Roche Diagnostics\u8d5e\u52a9\u7684\u5e74\u5ea6\u51dd\u8840\u79d1\u5b66\u4e0e\u6559\u80b2\u4f1a\u8bae pro-COAG<\/a>\u4e0a\uff0c\u7ebd\u7ea6Hofstra\/Northwell\u5927\u5b66\u533b\u5b66\u9662\u6559\u6388\u3001 Northwell Health System\u591a\u9662\u533a\u6297\u51dd\u4e0e\u4e34\u5e8a\u8840\u6813\u670d\u52a1\u4e3b\u4efbAlex C Spyropoulos\u6559\u6388\u5c31\u4f4f\u9662\u60a3\u8005\u8840\u6813\u7ba1\u7406\u8fdb\u884c\u4e86\u4e13\u9898\u6f14\u8bb2\u3002\u5176\u6f14\u8bb2\u805a\u7126\u6025\u6027\u5185\u79d1\u51fa\u9662\u60a3\u8005\u4e0e\u91cd\u75c7SARS-CoV-2\uff08COVID-19\uff09\u60a3\u8005\u7684\u8840\u6813\u9884\u9632\u3002<\/p>\n

\u636e\u4f30\u8ba1\uff0c\u7f8e\u6b27\u5730\u533a\u7ea62000\u4e07\u60a3\u8005\u9762\u4e34\u9759\u8109\u8840\u6813\u6813\u585e\uff08VTE\uff09\u98ce\u9669\uff0c\u800cCOVID-19\u76f8\u5173\u7684\u9ad8\u51dd\u72b6\u6001\u52a0\u5267\u4e86\u8fd9\u4e00\u5c40\u9762\u3002\u975eCOVID-19\u75c5\u4f8b\u4e2d\uff0c50-70%\u7684\u75c7\u72b6\u6027VTE\u548c70-80%\u7684\u81f4\u547d\u80ba\u6813\u585e\uff08PE\uff09\u53d1\u751f\u4e8e\u6025\u6027\u5185\u79d1\u60a3\u8005\u7fa4\u4f53\uff0c\u8be5\u7fa4\u4f53\u7279\u5f81\u5305\u62ec\uff1a\u5e74\u9f84\u8d8570\u5c81\u3001\u663e\u8457\u5236\u52a8\u671f\uff08\u5b9a\u4e49\u4e3a3\u5929\u53ca\u4ee5\u4e0a\uff09\u3001\u4ee5\u53ca\u4f34\u968f\u5fc3\u80ba\u529f\u80fd\u50a8\u5907\u53d7\u635f\u548c\/\u6216\u8840\u6813\u98ce\u9669\u5347\u9ad8\u7684\u591a\u79cd\u5408\u5e76\u75c7[1]\u3002<\/p>\n

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\u4e34\u5e8a\u533b\u5e08\u4e0e\u6307\u5357\u9700\u91cd\u89c6\u8fd9\u4e00\u9ad8\u98ce\u9669\u671f\u3002\u95e8\u8bca\u76f4\u63a5\u53e3\u670d\u6297\u51dd\u836f\uff08DOAC\uff1b\u5229\u4f10\u6c99\u73ed\u4e0e\u8d1d\u66f2\u897f\u73ed\uff09\u9884\u9632\u8bd5\u9a8c\u8868\u660e\uff1a\u5e94\u9488\u5bf9\u9ad8VTE\u98ce\u9669\/\u4f4e\u51fa\u8840\u98ce\u9669\u4eba\u7fa4\uff0c\u00a0\u91c7\u7528\u4e34\u5e8a\u51b3\u7b56\u652f\u6301\u548c\/\u6216\u7535\u5b50\u5065\u5eb7\u8bb0\u5f55\u4e92\u64cd\u4f5c\u6027\u6307\u5bfc\u7684\u4e2a\u4f53\u5316\u98ce\u9669\u9002\u5e94\u7b56\u7565[2,3]\u3002\u00a0\u5e94\u7528\u7ecf\u8fc7\u9a8c\u8bc1\u7684VTE\u98ce\u9669\u8bc4\u4f30\u6a21\u578b\uff08\u5982Padua\u548cIMPROVE+D-\u4e8c\u805a\u4f53\uff09\u4e8e\u5165\u9662\u53ca\u51fa\u9662\u65f6\u8f85\u52a9\u51b3\u7b56\u5177\u6709\u4ef7\u503c\uff0c\u4f46\u73b0\u884c\u6307\u5357\u5c1a\u672a\u7edf\u4e00[4,5]\u3002<\/p>\n

SARS-CoV-2\u5e26\u6765\u76f8\u5173\u4f46\u72ec\u7279\u7684\u6311\u6218\u3002\u8be5\u611f\u67d3\u901a\u8fc7\u8840\u7ba1\u529f\u80fd\u969c\u788d\u4e0e\u708e\u75c7\u56e0\u5b50\/\u51dd\u8840\u53c2\u6570\u5347\u9ad8\u7684\u534f\u540c\u4f5c\u7528\uff0c\u8bf1\u53d1\u975e\u5178\u578b\u9ad8\u51dd\u72b6\u6001\u3002\u5176\u7279\u5f81\u5305\u62ec\uff1aVTE\u53d1\u751f\u7387\u5347\u9ad83-5\u500d\u3001D-\u4e8c\u805a\u4f53\u8d85\u6b63\u5e38\u4e0a\u96504-6\u500d\u6216\u66f4\u9ad8\uff08\u4f34\u968f2-5\u500d\u6b7b\u4ea1\u7387\u589e\u957f\uff09\u3001\u5f02\u5e38\u51dd\u8840\u5206\u578b\u53ca\u8840\u6813\u7a81\u7834\u4e8b\u4ef6[6]\u3002<\/p>\n

\u56e0\u6b64DOAC\u4e0e\u4f4e\u5206\u5b50\u809d\u7d20\uff08LMWH\uff09\u7684\u7528\u836f\u65f6\u673a\u53ca\u5242\u91cf\u81f3\u5173\u91cd\u8981\uff1a\u6240\u6709\u65e0\u9ad8\u51fa\u8840\u98ce\u9669\u7684COVID-19\u4f4f\u9662\u60a3\u8005\u5747\u5e94\u63a5\u53d7\u9884\u9632\u5242\u91cfLMWH\uff0c\u800cD-\u4e8c\u805a\u4f53\u8d85\u8fc7\u6b63\u5e38\u4e0a\u9650\u4e24\u500d\u6216\u9700\u6c27\u7597\u7684\u6781\u9ad8\u5371\u60a3\u8005\u53ef\u80fd\u9700\u6cbb\u7597\u5242\u91cfLMWH\u8fdb\u884c\u8840\u6813\u9884\u9632\u3002<\/p>\n

\u6b64\u5916\uff0cIMPROVE VTE\u8bc4\u5206\u22654\u5206\u62162-3\u5206\u4f34D-\u4e8c\u805a\u4f53\u8d85\u5f53\u5730\u5b9e\u9a8c\u5ba4\u6b63\u5e38\u503c\u4e24\u500d\u8005\uff0c\u82e5\u65e0\u9ad8\u51fa\u8840\u98ce\u9669\uff0c\u53ef\u53d7\u76ca\u4e8e35\u5929\u5229\u4f10\u6c99\u73ed10mg\u7684\u5ef6\u957f\u8840\u6813\u9884\u9632\u6cbb\u7597\u3002\u65b0\u7248COVID-19\u6307\u5357\u5c06\u4f53\u73b0\u8fd9\u4e9b\u8fdb\u5c55\u3002<\/p>\n

Alex C Spyropoulos\u6559\u6388\u73b0\u4efbMedicine, Zucker School of Medicine\u6559\u6388\u3001Northwell Health System\u6297\u51dd\u4e0e\u4e34\u5e8a\u8840\u6813\u670d\u52a1\u4e3b\u4efb\u3002\u7ebd\u7ea6\u5dde\uff1bFeinstein Institute for Medical Research\u5065\u5eb7\u521b\u65b0\u4e0e\u6210\u679c\u4e2d\u5fc3\u6559\u6388\u3002Northwell Health System\u8840\u6813\u9886\u5bfc\u529b\u59d4\u5458\u4f1a\u8054\u5408\u4e3b\u5e2d\uff1b\u300a\u8840\u6813\u4e0e\u6b62\u8840\u300b\u680f\u76ee\u7f16\u8f91\uff1b\u300a\u533b\u9662\u533b\u5b66\u300b\u7f16\u59d4\u4f1a\u6210\u5458\u3002<\/em><\/p>\n

\n

\u53c2\u8003\u6587\u732e\uff1a\u00a0<\/em><\/p>\n

\n[1]<\/a> Decousus, H, et al.Chest, 2011. 139(1):69\u201379.
\n[2]<\/a> Spyropoulos, AC, et al. TH Open, 2020. 04(01):e59\u2013e65.
\n[3]<\/a> Cohen, AT, et al., J Thromb Haemost, 2014. 12(4):479\u2013487.
\n[4]<\/a> Spyropoulos, AC, et al. Res Pract Thromb Haemost, 2021. 5(2):296\u2013300.
\n[5]<\/a> Rosenberg, DJ, et al. Thromb Haemost, 2016. 116(09):530\u2013536.
\n[6]<\/a> Goldin, M, et al. J Thromb Thrombolysis, 2021. 52(4):1032\u20131035.<\/p>\n","protected":false},"excerpt":{"rendered":"

\u57282022\u5e743\u6708\u7531Roche Diagnostics\u8d5e\u52a9\u7684\u5e74\u5ea6\u51dd\u8840\u79d1\u5b66\u4e0e\u6559\u80b2\u4f1a\u8bae pro-COAG\u4e0a\uff0c\u7ebd\u7ea6Hofstra\/Northwell\u5927\u5b66\u533b\u5b66\u9662\u6559\u6388\u3001 Northwell Health System\u591a\u9662\u533a\u6297\u51dd\u4e0e\u4e34\u5e8a\u8840\u6813\u670d\u52a1\u4e3b\u4efbAlex C Spyropoulos\u6559\u6388\u5c31\u4f4f\u9662\u60a3\u8005\u8840\u6813\u7ba1\u7406\u8fdb\u884c\u4e86\u4e13\u9898\u6f14\u8bb2\u3002\u5176\u6f14\u8bb2\u805a\u7126\u6025\u6027\u5185\u79d1\u51fa\u9662\u60a3\u8005\u4e0e\u91cd\u75c7SARS-CoV-2\uff08COVID-19\uff09\u60a3\u8005\u7684\u8840\u6813\u9884\u9632\u3002 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SARS-CoV-2\u5e26\u6765\u76f8\u5173\u4f46\u72ec\u7279\u7684\u6311\u6218\u3002\u8be5\u611f\u67d3\u901a\u8fc7\u8840\u7ba1\u529f\u80fd\u969c\u788d\u4e0e\u708e\u75c7\u56e0\u5b50\/\u51dd\u8840\u53c2\u6570\u5347\u9ad8\u7684\u534f\u540c\u4f5c\u7528\uff0c\u8bf1\u53d1\u975e\u5178\u578b\u9ad8\u51dd\u72b6\u6001\u3002\u5176\u7279\u5f81\u5305\u62ec\uff1aVTE\u53d1\u751f\u7387\u5347\u9ad83-5\u500d\u3001D-\u4e8c\u805a\u4f53\u8d85\u6b63\u5e38\u4e0a\u96504-6\u500d\u6216\u66f4\u9ad8\uff08\u4f34\u968f2-5\u500d\u6b7b\u4ea1\u7387\u589e\u957f\uff09\u3001\u5f02\u5e38\u51dd\u8840\u5206\u578b\u53ca\u8840\u6813\u7a81\u7834\u4e8b\u4ef6[6]\u3002 \u56e0\u6b64DOAC\u4e0e\u4f4e\u5206\u5b50\u809d\u7d20\uff08LMWH\uff09\u7684\u7528\u836f\u65f6\u673a\u53ca\u5242\u91cf\u81f3\u5173\u91cd\u8981\uff1a\u6240\u6709\u65e0\u9ad8\u51fa\u8840\u98ce\u9669\u7684COVID-19\u4f4f\u9662\u60a3\u8005\u5747\u5e94\u63a5\u53d7\u9884\u9632\u5242\u91cfLMWH\uff0c\u800cD-\u4e8c\u805a\u4f53\u8d85\u8fc7\u6b63\u5e38\u4e0a\u9650\u4e24\u500d\u6216\u9700\u6c27\u7597\u7684\u6781\u9ad8\u5371\u60a3\u8005\u53ef\u80fd\u9700\u6cbb\u7597\u5242\u91cfLMWH\u8fdb\u884c\u8840\u6813\u9884\u9632\u3002 \u6b64\u5916\uff0cIMPROVE VTE\u8bc4\u5206\u22654\u5206\u62162-3\u5206\u4f34D-\u4e8c\u805a\u4f53\u8d85\u5f53\u5730\u5b9e\u9a8c\u5ba4\u6b63\u5e38\u503c\u4e24\u500d\u8005\uff0c\u82e5\u65e0\u9ad8\u51fa\u8840\u98ce\u9669\uff0c\u53ef\u53d7\u76ca\u4e8e35\u5929\u5229\u4f10\u6c99\u73ed10mg\u7684\u5ef6\u957f\u8840\u6813\u9884\u9632\u6cbb\u7597\u3002\u65b0\u7248COVID-19\u6307\u5357\u5c06\u4f53\u73b0\u8fd9\u4e9b\u8fdb\u5c55\u3002 Alex C Spyropoulos\u6559\u6388\u73b0\u4efbMedicine, Zucker School of Medicine\u6559\u6388\u3001Northwell Health System\u6297\u51dd\u4e0e\u4e34\u5e8a\u8840\u6813\u670d\u52a1\u4e3b\u4efb\u3002\u7ebd\u7ea6\u5dde\uff1bFeinstein Institute for Medical Research\u5065\u5eb7\u521b\u65b0\u4e0e\u6210\u679c\u4e2d\u5fc3\u6559\u6388\u3002Northwell Health System\u8840\u6813\u9886\u5bfc\u529b\u59d4\u5458\u4f1a\u8054\u5408\u4e3b\u5e2d\uff1b\u300a\u8840\u6813\u4e0e\u6b62\u8840\u300b\u680f\u76ee\u7f16\u8f91\uff1b\u300a\u533b\u9662\u533b\u5b66\u300b\u7f16\u59d4\u4f1a\u6210\u5458\u3002 \u53c2\u8003\u6587\u732e\uff1a\u00a0 [1] Decousus, H, et al.Chest, 2011. 139(1):69\u201379. [2] Spyropoulos, AC, et al. TH Open, 2020. 04(01):e59\u2013e65. 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