{"id":145674,"date":"2023-01-16T02:19:53","date_gmt":"2023-01-16T02:19:53","guid":{"rendered":"https:\/\/labinsights.com\/acf_article\/%e7%99%8c%e7%97%87%e7%9b%b8%e5%85%b3%e8%a1%80%e6%a0%93%e4%b8%ad%e7%9a%84%e7%94%9f%e7%89%a9%e6%a0%87%e5%bf%97%e7%89%a9%ef%bc%9aanna-falanga%e6%95%99%e6%8e%88%e4%b8%8ecinzia-giaccherini%e7%9a%84\/"},"modified":"2026-02-09T05:14:14","modified_gmt":"2026-02-09T05:14:14","slug":"biomarkers-in-cancer-associated-thrombosis-insights-from-prof-anna-falanga-and-cinzia-giaccherini","status":"publish","type":"acf_article","link":"https:\/\/labinsights.com\/zhcn\/disease-area\/oncology\/biomarkers-in-cancer-associated-thrombosis-insights-from-prof-anna-falanga-and-cinzia-giaccherini\/","title":{"rendered":"\u764c\u75c7\u76f8\u5173\u8840\u6813\u4e2d\u7684\u751f\u7269\u6807\u5fd7\u7269\uff1aAnna Falanga\u6559\u6388\u4e0eCinzia Giaccherini\u7684\u89c1\u89e3"},"content":{"rendered":"<p class=\"text-align-justify\">\u57282022\u5e74\u4e16\u754c\u8840\u6813\u65e5<a href=\"https:\/\/diagnostics.roche.com\/global\/en\/events\/biomarkers-in-cancer-associated-thrombosis.html\" target=\"_blank\" rel=\"noopener\">\u7f51\u7edc\u7814\u8ba8<\/a>\u4f1a\u4e0a\uff0c\u7c73\u5170\u6bd4\u53ef\u5361\u5927\u5b66\u8840\u6db2\u5b66\u6559\u6388Anna Falanga\u4e0e\u7814\u7a76\u51dd\u8840\u9886\u57df\u5341\u4f59\u5e74\u7684\u751f\u7269\u5b66\u5bb6Cinzia Giaccherini\uff0c\u63a2\u8ba8\u4e86\u751f\u7269\u6807\u5fd7\u7269\u5bf9\u764c\u75c7\u76f8\u5173\u8840\u6813\uff08CAT\uff09\u7684\u9884\u6d4b\u4f5c\u7528\u3002<\/p>\n<p class=\"text-align-justify\">Anna Falanga\u6559\u6388\u9996\u5148\u6982\u8ff0\u4e86CAT\u98ce\u9669\u9884\u6d4b\u4e0e\u9884\u9632\u3002\u82f1\u56fd\u4e0e\u4e39\u9ea6\u961f\u5217\u7814\u7a76\u663e\u793a\uff0c\u764c\u75c7\u60a3\u8005\u9759\u8109\u8840\u6813\u6813\u585e\uff08VTE\uff09\u98ce\u9669\u662f\u975e\u764c\u75c7\u60a3\u8005\u76844-11\u500d\uff08\u53d6\u51b3\u4e8e\u764c\u75c7\u7c7b\u578b\uff09\uff0cVTE\u663e\u8457\u5f71\u54cd\u764c\u75c7\u60a3\u8005\u53d1\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u3002<\/p>\n<p class=\"text-align-justify\">\u4e3a\u9884\u9632VTE\uff0c\u9700\u8bc6\u522b\u53ef\u80fd\u53d7\u76ca\u4e8e\u521d\u7ea7\u8840\u6813\u9884\u9632\u7684\u9ad8\u98ce\u9669\u764c\u75c7\u60a3\u8005\u3002Khorana\u8bc4\u5206\u7b49\u98ce\u9669\u8bc4\u4f30\u6a21\u5757\uff08RAMs\uff09\u53ef\u9884\u6d4b\u60a3\u8005VTE\u98ce\u9669\u3002\u7ed3\u5408\u751f\u7269\u6807\u5fd7\u7269\u53ef\u4f18\u5316RAMs\u7684\u9884\u6d4b\u80fd\u529b\u3002<\/p>\n<p class=\"text-align-justify\">Cinzia Giaccherini\u968f\u540e\u8ba8\u8bba\u4e86\u80ba\u764cCAT\u9884\u6d4b\u4e0e\u75be\u75c5\u9884\u540e\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002D-\u4e8c\u805a\u4f53\u7b49\u51dd\u8840\u6807\u5fd7\u7269\u88ab\u8ba4\u4e3a\u5728\u8bc4\u4f30\u60a3\u8005\u4e2a\u4f53\u8840\u6813\u98ce\u9669\u65b9\u9762\u5177\u6709\u6f5c\u5728\u4ef7\u503c\u3002\u6709\u8bc1\u636e\u652f\u6301\u5176\u5728\u80ba\u764c\u60a3\u8005\u4e2d\u7684\u5e94\u7528\uff0c\u8fd9\u4e9b\u6807\u5fd7\u7269\u4e5f\u53ef\u80fd\u63d0\u793a\u4e0d\u826f\u9884\u540e\u3002<\/p>\n<p class=\"text-align-justify\">\u591a\u9879\u7814\u7a76\u8868\u660eD-\u4e8c\u805a\u4f53\u8840\u6d46\u6c34\u5e73\u5347\u9ad8\u4e0e\u80bf\u7624\u8d1f\u8377\u5927\u3001\u75be\u75c5\u8fdb\u5c55\u548c\u6b7b\u4ea1\u7387\u663e\u8457\u76f8\u5173\u3002\u9700\u8fdb\u4e00\u6b65\u7814\u7a76\u4ee5\u5f3a\u5316\u73b0\u6709\u8bc1\u636e\uff0c\u63a8\u52a8\u51dd\u8840\u6807\u5fd7\u7269\u6a21\u578b\u5728\u672a\u6765\u4e34\u5e8a\u5b9e\u8df5\u4e2d\u7684\u5e94\u7528\u3002<\/p>\n<p class=\"text-align-justify\">\u95ee\u7b54\u73af\u8282\u6307\u51fa\uff0c\u80ba\u6813\u585e\u5728\u80ba\u764c\u60a3\u8005\u4e2d\u6700\u5e38\u89c1\uff0c\u901a\u5e38\u662f\u5728\u764c\u75c7\u7b5b\u67e5\u4e2d\u88ab\u53d1\u73b0\u3002\u5173\u4e8e\u4f7f\u7528\u827e\u591a\u6c99\u73ed\u6cbb\u7597\u9759\u8109\u8840\u6813\u6813\u585e\u75c7\uff08VTE\uff09\uff0c\u5efa\u8bae\u5728\u8c03\u6574\u5242\u91cf\u524d\u4ee5\u76f8\u540c\u5242\u91cf\u6301\u7eed\u6cbb\u759712\u4e2a\u6708\uff08\u82e5VTE\u672a\u6d88\u9000\uff09\u3002<\/p>\n<p class=\"text-align-justify\">D-\u4e8c\u805a\u4f53\u88ab\u8ba4\u4e3a\u662fVTE\u7684\u6f5c\u5728\u6807\u5fd7\u7269\u548c\u75be\u75c5\u9884\u540e\u7684\u9884\u6d4b\u6307\u6807\u3002\u6709\u89c2\u70b9\u8ba4\u4e3a\uff0c\u8001\u9f84\u5316\u4eba\u53e3\u53ca\u65b0\u578b\u764c\u75c7\u6cbb\u7597\u624b\u6bb5\u53ef\u80fd\u4e0e\u6240\u6709\u764c\u75c7\u7c7b\u578b\u4e2d\u8840\u6813\u5f62\u6210\u98ce\u9669\u4e0a\u5347\u6709\u5173\u3002<\/p>\n<p class=\"text-align-justify\"><em>Anna Falanga\u6559\u6388\uff0c\u533b\u5b66\u535a\u58eb\uff0c\u662f\u610f\u5927\u5229\u7c73\u5170\u6bd4\u53ef\u5361\u5927\u5b66\u8840\u6db2\u5b66\u6559\u6388\uff0c\u517c\u8d1d\u52a0\u83abPapa Giovanni   XXIII\u533b\u9662\u514d\u75ab\u8840\u6db2\u5b66\u4e0e\u8f93\u8840\u533b\u5b66\u79d1\u53ca\u8840\u6813\u4e0e\u6b62\u8840\u4e2d\u5fc3\u4e3b\u4efb\u3002 \u5979\u5df2\u53d1\u8868300\u4f59\u7bc7\u5b66\u672f\u8457\u4f5c\uff0c\u62c5\u4efb21\u5377\u671f\u520a\u7684\u7279\u9080\u7f16\u8f91\uff0c\u662f\u764c\u75c7\u4e0e\u8840\u6813\u5f62\u6210\u9886\u57df\u7684\u6743\u5a01\u4e13\u5bb6\u3002 <\/em><\/p>\n<p class=\"text-align-justify\"><em>Cinzia Giaccherini\u662f\u7814\u7a76\u751f\u7269\u5b66\u5bb6\uff0c\u5728\u610f\u5927\u5229\u8d1d\u52a0\u83abPapa Giovanni   XXIII\u533b\u9662\u514d\u75ab\u8840\u6db2\u5b66\u4e0e\u8f93\u8840\u533b\u5b66\u79d1\u6b62\u8840\u4e0e\u8840\u6813\u5b9e\u9a8c\u5ba4\u62e5\u6709\u903e10\u5e74\u5de5\u4f5c\u7ecf\u9a8c\u3002 \u5979\u540c\u65f6\u6b63\u5728\u7c73\u5170\u5927\u5b66\u653b\u8bfb\u533b\u5b66\u7edf\u8ba1\u4e0e\u751f\u7269\u8ba1\u91cf\u5b66\u7814\u7a76\u751f\u4e13\u4e1a\u3002 <\/em><\/p>\n<p class=\"text-align-justify\"><em><strong>\u8865\u5145\u8d44\u6e90\uff1a<\/strong><\/em><br \/>\n<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2468294222000478?via%3Dihub\" target=\"_blank\" rel=\"noopener\">[1]<\/a> Falanga, A.et al. (2022) \u201cHow well do European patients understand cancer-associated thrombosis?A patient survey,\u201d Cancer Treatment and Research Communications, 31, p. 100557. \u68c0\u7d22\u94fe\u63a5\uff1ahttps:\/\/doi.org\/10.1016\/j.ctarc.2022.100557 \u3002<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34485812\/\" target=\"_blank\" rel=\"noopener\">[2] <\/a>Falanga, A.et al. (2021) \u201cManagement of cancer-associated thrombosis: Unmet needs and future perspectives,\u201d TH Open, 05(03).\u68c0\u7d22\u94fe\u63a5\uff1ahttps:\/\/doi.org\/10.1055\/s-0041-1736037\u3002<br \/>\n<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/rth2.12744\" target=\"_blank\" rel=\"noopener\">[3]<\/a> Falanga, A.et al. (2022) \u201cThrombotic complications in patients with cancer: Advances in pathogenesis, prevention, and treatment\u2014a report from ICTHIC 2021,\u201d Research and Practice in Thrombosis and Haemostasis, 6(5).\u68c0\u7d22\u94fe\u63a5\uff1ahttps:\/\/doi.org\/10.1002\/rth2.12744\u3002<br \/>\n<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0006497118701304\" target=\"_blank\" rel=\"noopener\">[4]<\/a> Pesenti, M.et al. (2020) \u201cThrombin generation and D-dimer significantly predict for early disease progression and mortality in patients with gastrointestinal cancer,\u201d Blood, 136(Supplement 1), pp. 32\u201332. \u68c0\u7d22\u94fe\u63a5\uff1ahttps:\/\/doi.org\/10.1182\/blood-2020-136631\u3002<br \/>\n<a href=\"https:\/\/ashpublications.org\/blood\/article\/134\/Supplement_1\/3642\/428193\/Thrombotic-Risk-Assessment-in-a-Prospective-Cohort\" target=\"_blank\" rel=\"noopener\">[5]<\/a> Falanga, A.et al. (2019) \u201cThrombotic risk assessment in a prospective cohort of newly diagnosed ambulatory cancer patients candidate to Chemotherapy,\u201d Blood, 134(Supplement_1), pp. 3642\u20133642. \u68c0\u7d22\u94fe\u63a5\uff1ahttps:\/\/doi.org\/10.1182\/blood-2019-129901\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u57282022\u5e74\u4e16\u754c\u8840\u6813\u65e5\u7f51\u7edc\u7814\u8ba8\u4f1a\u4e0a\uff0c\u7c73\u5170\u6bd4\u53ef\u5361\u5927\u5b66\u8840\u6db2\u5b66\u6559\u6388Anna Falanga\u4e0e\u7814\u7a76\u51dd\u8840\u9886\u57df\u5341\u4f59\u5e74\u7684\u751f\u7269\u5b66\u5bb6Cinzia Giaccherini\uff0c\u63a2\u8ba8\u4e86\u751f\u7269\u6807\u5fd7\u7269\u5bf9\u764c\u75c7\u76f8\u5173\u8840\u6813\uff08CAT\uff09\u7684\u9884\u6d4b\u4f5c\u7528\u3002 Anna Falanga\u6559\u6388\u9996\u5148\u6982\u8ff0\u4e86CAT\u98ce\u9669\u9884\u6d4b\u4e0e\u9884\u9632\u3002\u82f1\u56fd\u4e0e\u4e39\u9ea6\u961f\u5217\u7814\u7a76\u663e\u793a\uff0c\u764c\u75c7\u60a3\u8005\u9759\u8109\u8840\u6813\u6813\u585e\uff08VTE\uff09\u98ce\u9669\u662f\u975e\u764c\u75c7\u60a3\u8005\u76844-11\u500d\uff08\u53d6\u51b3\u4e8e\u764c\u75c7\u7c7b\u578b\uff09\uff0cVTE\u663e\u8457\u5f71\u54cd\u764c\u75c7\u60a3\u8005\u53d1\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u3002 \u4e3a\u9884\u9632VTE\uff0c\u9700\u8bc6\u522b\u53ef\u80fd\u53d7\u76ca\u4e8e\u521d\u7ea7\u8840\u6813\u9884\u9632\u7684\u9ad8\u98ce\u9669\u764c\u75c7\u60a3\u8005\u3002Khorana\u8bc4\u5206\u7b49\u98ce\u9669\u8bc4\u4f30\u6a21\u5757\uff08RAMs\uff09\u53ef\u9884\u6d4b\u60a3\u8005VTE\u98ce\u9669\u3002\u7ed3\u5408\u751f\u7269\u6807\u5fd7\u7269\u53ef\u4f18\u5316RAMs\u7684\u9884\u6d4b\u80fd\u529b\u3002 Cinzia Giaccherini\u968f\u540e\u8ba8\u8bba\u4e86\u80ba\u764cCAT\u9884\u6d4b\u4e0e\u75be\u75c5\u9884\u540e\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002D-\u4e8c\u805a\u4f53\u7b49\u51dd\u8840\u6807\u5fd7\u7269\u88ab\u8ba4\u4e3a\u5728\u8bc4\u4f30\u60a3\u8005\u4e2a\u4f53\u8840\u6813\u98ce\u9669\u65b9\u9762\u5177\u6709\u6f5c\u5728\u4ef7\u503c\u3002\u6709\u8bc1\u636e\u652f\u6301\u5176\u5728\u80ba\u764c\u60a3\u8005\u4e2d\u7684\u5e94\u7528\uff0c\u8fd9\u4e9b\u6807\u5fd7\u7269\u4e5f\u53ef\u80fd\u63d0\u793a\u4e0d\u826f\u9884\u540e\u3002 \u591a\u9879\u7814\u7a76\u8868\u660eD-\u4e8c\u805a\u4f53\u8840\u6d46\u6c34\u5e73\u5347\u9ad8\u4e0e\u80bf\u7624\u8d1f\u8377\u5927\u3001\u75be\u75c5\u8fdb\u5c55\u548c\u6b7b\u4ea1\u7387\u663e\u8457\u76f8\u5173\u3002\u9700\u8fdb\u4e00\u6b65\u7814\u7a76\u4ee5\u5f3a\u5316\u73b0\u6709\u8bc1\u636e\uff0c\u63a8\u52a8\u51dd\u8840\u6807\u5fd7\u7269\u6a21\u578b\u5728\u672a\u6765\u4e34\u5e8a\u5b9e\u8df5\u4e2d\u7684\u5e94\u7528\u3002 \u95ee\u7b54\u73af\u8282\u6307\u51fa\uff0c\u80ba\u6813\u585e\u5728\u80ba\u764c\u60a3\u8005\u4e2d\u6700\u5e38\u89c1\uff0c\u901a\u5e38\u662f\u5728\u764c\u75c7\u7b5b\u67e5\u4e2d\u88ab\u53d1\u73b0\u3002\u5173\u4e8e\u4f7f\u7528\u827e\u591a\u6c99\u73ed\u6cbb\u7597\u9759\u8109\u8840\u6813\u6813\u585e\u75c7\uff08VTE\uff09\uff0c\u5efa\u8bae\u5728\u8c03\u6574\u5242\u91cf\u524d\u4ee5\u76f8\u540c\u5242\u91cf\u6301\u7eed\u6cbb\u759712\u4e2a\u6708\uff08\u82e5VTE\u672a\u6d88\u9000\uff09\u3002 D-\u4e8c\u805a\u4f53\u88ab\u8ba4\u4e3a\u662fVTE\u7684\u6f5c\u5728\u6807\u5fd7\u7269\u548c\u75be\u75c5\u9884\u540e\u7684\u9884\u6d4b\u6307\u6807\u3002\u6709\u89c2\u70b9\u8ba4\u4e3a\uff0c\u8001\u9f84\u5316\u4eba\u53e3\u53ca\u65b0\u578b\u764c\u75c7\u6cbb\u7597\u624b\u6bb5\u53ef\u80fd\u4e0e\u6240\u6709\u764c\u75c7\u7c7b\u578b\u4e2d\u8840\u6813\u5f62\u6210\u98ce\u9669\u4e0a\u5347\u6709\u5173\u3002 Anna Falanga\u6559\u6388\uff0c\u533b\u5b66\u535a\u58eb\uff0c\u662f\u610f\u5927\u5229\u7c73\u5170\u6bd4\u53ef\u5361\u5927\u5b66\u8840\u6db2\u5b66\u6559\u6388\uff0c\u517c\u8d1d\u52a0\u83abPapa Giovanni XXIII\u533b\u9662\u514d\u75ab\u8840\u6db2\u5b66\u4e0e\u8f93\u8840\u533b\u5b66\u79d1\u53ca\u8840\u6813\u4e0e\u6b62\u8840\u4e2d\u5fc3\u4e3b\u4efb\u3002 \u5979\u5df2\u53d1\u8868300\u4f59\u7bc7\u5b66\u672f\u8457\u4f5c\uff0c\u62c5\u4efb21\u5377\u671f\u520a\u7684\u7279\u9080\u7f16\u8f91\uff0c\u662f\u764c\u75c7\u4e0e\u8840\u6813\u5f62\u6210\u9886\u57df\u7684\u6743\u5a01\u4e13\u5bb6\u3002 Cinzia Giaccherini\u662f\u7814\u7a76\u751f\u7269\u5b66\u5bb6\uff0c\u5728\u610f\u5927\u5229\u8d1d\u52a0\u83abPapa Giovanni XXIII\u533b\u9662\u514d\u75ab\u8840\u6db2\u5b66\u4e0e\u8f93\u8840\u533b\u5b66\u79d1\u6b62\u8840\u4e0e\u8840\u6813\u5b9e\u9a8c\u5ba4\u62e5\u6709\u903e10\u5e74\u5de5\u4f5c\u7ecf\u9a8c\u3002 \u5979\u540c\u65f6\u6b63\u5728\u7c73\u5170\u5927\u5b66\u653b\u8bfb\u533b\u5b66\u7edf\u8ba1\u4e0e\u751f\u7269\u8ba1\u91cf\u5b66\u7814\u7a76\u751f\u4e13\u4e1a\u3002 \u8865\u5145\u8d44\u6e90\uff1a [1] Falanga, A.et al. (2022) \u201cHow well do European patients understand cancer-associated thrombosis?A patient survey,\u201d Cancer Treatment and Research Communications, 31, p. 100557. \u68c0\u7d22\u94fe\u63a5\uff1ahttps:\/\/doi.org\/10.1016\/j.ctarc.2022.100557 \u3002 [2] Falanga, A.et al. 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