{"id":85246,"date":"2021-08-04T03:57:33","date_gmt":"2021-08-04T03:57:33","guid":{"rendered":"https:\/\/prod.wplb.labbenchmarking.com\/uncategorized\/%e5%87%9d%e8%a1%80%e8%af%8a%e6%96%ad%e5%a6%82%e4%bd%95%e6%94%af%e6%8c%81covid-19%e7%96%ab%e8%8b%97%e6%8e%a5%e7%a7%8d%e5%92%8c%e6%82%a3%e8%80%85%e7%ae%a1%e7%90%86\/"},"modified":"2026-01-22T04:23:58","modified_gmt":"2026-01-22T04:23:58","slug":"how-coagulation-diagnostics-support-covid-19-vaccination-and-patient-management","status":"publish","type":"acf_article","link":"https:\/\/labinsights.com\/zhcn\/disease-area\/coagulation\/how-coagulation-diagnostics-support-covid-19-vaccination-and-patient-management\/","title":{"rendered":"\u51dd\u8840\u8bca\u65ad\u5982\u4f55\u652f\u6301COVID-19\u75ab\u82d7\u63a5\u79cd\u548c\u60a3\u8005\u7ba1\u7406"},"content":{"rendered":"

\u611f\u67d3\u65b0\u51a0\u75c5\u6bd2\u4e0e\u8840\u6813\u5f62\u6210\u6709\u5173\uff0c\u8840\u6813\u53ef\u80fd\u7d2f\u53ca\u9759\u8109\u548c\u52a8\u8109\u3002\u56e0\u611f\u67d3\u65b0\u51a0\u75c5\u6bd2\u800c\u4f4f\u9662\u7684\u60a3\u8005\u8840\u6813\u98ce\u9669\u6700\u9ad8\uff0c\u666e\u901a\u75c5\u623f\u60a3\u8005\u7684\u8840\u6813\u53d1\u751f\u7387\u7ea6\u4e3a 5%\uff0c\u800c\u91cd\u75c7\u76d1\u62a4\u5ba4 (ICU) \u63a5\u53d7\u751f\u547d\u652f\u6301\u7684\u60a3\u8005\u8840\u6813\u53d1\u751f\u7387\u9ad8\u8fbe 20%\u3002\u65e0\u9700\u4f4f\u9662\u7684\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3\u8005\u8840\u6813\u98ce\u9669\u8f83\u4f4e\uff0c\u7ea6\u4e3a 1% [1]\u3002<\/p>\n

\u867d\u7136\u975e\u5e38\u7f55\u89c1\uff0c\u4f46\u63a5\u79cd\u817a\u75c5\u6bd2\u75ab\u82d7\u4e5f\u53ef\u80fd\u5bfc\u81f4\u8840\u6813\uff0c\u8fd9\u79cd\u60c5\u51b5\u79f0\u4e3a\u75ab\u82d7\u8bf1\u5bfc\u7684\u8840\u6813\u6027\u8840\u5c0f\u677f\u51cf\u5c11\u75c7 (VITT)\u3002\u4e3a\u4e86\u66f4\u597d\u5730\u4e86\u89e3\u65b0\u51a0\u75c5\u6bd2\u75ab\u82d7\u63a5\u79cd\u548c\u60a3\u8005\u7ba1\u7406\u76f8\u5173\u7684\u5173\u952e\u51dd\u8840\u98ce\u9669\u548c\u6ce8\u610f\u4e8b\u9879\uff0c\u7f57\u6c0f\u8bca\u65ad\u4e9a\u592a\u533a\u8fd1\u671f\u91c7\u8bbf\u4e86\u9ad8\u7ea7\u987e\u95ee\u5434\u6052\u7956\u535a\u58eb\u3002\u65b0\u52a0\u5761\u4e2d\u592e\u533b\u9662\u8840\u6db2\u79d1\u4e3b\u4efb\u3002<\/p>\n

COVID-19 \u6cbb\u7597\u548c\u75ab\u82d7\u63a5\u79cd\u540e\u8bc4\u4f30\u4e2d\u7684\u51dd\u8840\u6807\u5fd7\u7269<\/h2>\n

\u8d8a\u6765\u8d8a\u591a\u7684\u5b9e\u9a8c\u5ba4\u8bc1\u636e\u8868\u660e\uff0cCOVID-19 \u611f\u67d3\u60a3\u8005\u7684\u51dd\u8840\u5f02\u5e38\u53d8\u5316\u53ef\u80fd\u662f\u4e25\u91cd\u7684\u708e\u75c7\u53cd\u5e94\u7684\u7ed3\u679c\uff0c\u800c\u4e0e\u5185\u5728\u7684\u4fc3\u51dd\u8840\u4f5c\u7528\u672c\u8eab\u65e0\u5173\u3002\u91cd\u75c7 COVID-19 \u611f\u67d3\u60a3\u8005\u7684\u51dd\u8840\u86cb\u767d\u6c34\u5e73\u53ef\u80fd\u663e\u8457\u5347\u9ad8\uff0c\u8fd9\u4e0e\u4e25\u91cd\u7684\u6025\u6027\u671f\u53cd\u5e94\u76f8\u7b26\u3002\u90e8\u5206\u91cd\u75c7\u80ba\u708e\u60a3\u8005\u53d1\u5c55\u4e3a\u75c5\u6bd2\u6027\u8113\u6bd2\u75c7\u3001\u5f25\u6563\u6027\u8840\u7ba1\u5185\u51dd\u8840 (DIC) \u548c\u591a\u5668\u5b98\u529f\u80fd\u8870\u7aed\u3002<\/p>\n

\u7531\u4e8eD-\u4e8c\u805a\u4f53\u662f\u8840\u6813\u60a3\u8005\u7684\u9633\u6027\u6807\u5fd7\u7269\uff0c\u4e00\u4e9b\u7814\u7a76\u8bd5\u56fe\u5c06D-\u4e8c\u805a\u4f53\u7eb3\u5165COVID-19\u4e25\u91cd\u7a0b\u5ea6\u7684\u9884\u6d4b\u4e2d\u3002\u201cD-\u4e8c\u805a\u4f53\u5df2\u88ab\u7eb3\u5165\u4e00\u4e9b\u7528\u4e8e\u8bc4\u4f30COVID-19\u60a3\u8005\u53d1\u751f\u9759\u8109\u8840\u6813\u6813\u585e\u98ce\u9669\u7684\u8bc4\u5206\u4f53\u7cfb\u4e2d\uff0c\u201d\u5434\u533b\u751f\u6307\u51fa\u3002\u201c\u4f46\u8981\u786e\u5b9a\u4e00\u4e2a\u4e34\u754c\u503c\u6765\u5224\u65ad\u75c5\u60c5\u662f\u5426\u52a0\u91cd\uff0c\u4ee5\u53ca\u8fd9\u4f1a\u5982\u4f55\u5f71\u54cd\u60a3\u8005\u7684\u6cbb\u7597\u5347\u7ea7\uff0c\u4e00\u76f4\u6709\u4e9b\u56f0\u96be\u3002\u201d<\/p>\n

\u201c\u4e00\u4e9b\u5e38\u7528\u7684\u98ce\u9669\u8bc4\u4f30\u6a21\u578b\u5305\u62ec\u6539\u826f\u7684D-\u4e8c\u805a\u4f53\u8bc4\u5206\u548cCaprini\u8bc4\u5206\uff0c\u201d\u4ed6\u8865\u5145\u9053\u3002\u201c\u4e00\u4e9b\u9a8c\u8bc1\u7814\u7a76\u8868\u660e\uff0c\u8fd9\u4e9b\u6a21\u578b\u5728\u9884\u6d4b\u54ea\u4e9b\u60a3\u8005\u5c5e\u4e8e\u9759\u8109\u8840\u6813\u6813\u585e\u4f4e\u98ce\u9669\u3001\u4e2d\u98ce\u9669\u6216\u9ad8\u98ce\u9669\u65b9\u9762\u6548\u679c\u663e\u8457\uff0c\u4ece\u800c\u6709\u52a9\u4e8e\u5408\u7406\u5730\u4e3a\u60a3\u8005\u4f7f\u7528\u6297\u51dd\u6cbb\u7597\u3002\u201d<\/p>\n

\u5bf9\u4e8e\u75ab\u82d7\u8bf1\u5bfc\u6027\u8840\u6813\u5f62\u6210\uff08VITT\uff09\u60a3\u8005\uff0c\u68c0\u6d4b\u901a\u5e38\u663e\u793a\u7ea4\u7ef4\u86cb\u767d\u539f\u6c34\u5e73\u4f4e\uff0c\u800cD-\u4e8c\u805a\u4f53\u6c34\u5e73\u663e\u8457\u5347\u9ad8\uff0c\u8fdc\u9ad8\u4e8e\u9759\u8109\u8840\u6813\u6813\u585e\u7684\u9884\u671f\u6c34\u5e73\u3002\u201c\u6211\u4eec\u77e5\u9053VITT\u7684\u6f5c\u5728\u53d1\u75c5\u65f6\u95f4\u901a\u5e38\u5728\u63a5\u79cd\u75ab\u82d7\u540e5\u81f328\u5929\u4e4b\u95f4\uff0c\u201d\u5434\u533b\u751f\u5f3a\u8c03\u8bf4\u3002\u201c\u6211\u4eec\u4e5f\u77e5\u9053\u5b83\u4f1a\u5bfc\u81f4\u4e00\u4e9b\u4e0d\u5e38\u89c1\u7684\u8840\u6813\u5f62\u6210\u90e8\u4f4d\uff0c\u4f8b\u5982\u8111\u9759\u8109\u7aa6\u8840\u6813\u5f62\u6210\u548c\u813e\u9759\u8109\u8840\u6813\u5f62\u6210\u3002\u201d<\/p>\n

\u5728 VITT \u60a3\u8005\u4e2d\u5df2\u68c0\u6d4b\u5230\u6297\u8840\u5c0f\u677f\u56e0\u5b50 4 (PF4) \u6297\u4f53\uff0c\u56e0\u6b64\uff0c\u5c3d\u7ba1\u60a3\u8005\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u809d\u7d20\u6cbb\u7597\uff0c\u4f46 VITT \u4e0e\u809d\u7d20\u8bf1\u5bfc\u7684\u8840\u5c0f\u677f\u51cf\u5c11\u75c7 (HIT) \u4ecd\u5b58\u5728\u76f8\u4f3c\u4e4b\u5904\u3002\u6297 PF4 \u6297\u4f53\u53ef\u901a\u8fc7 ELISA HIT \u68c0\u6d4b\u6cd5\u68c0\u6d4b\u5230\uff0c\u4f46\u901a\u5e38\u65e0\u6cd5\u901a\u8fc7\u5feb\u901f\u68c0\u6d4b\u6cd5\u68c0\u6d4b\u5230\uff0c\u56e0\u4e3a\u5feb\u901f\u68c0\u6d4b\u6cd5\u901a\u5e38\u57fa\u4e8e\u5316\u5b66\u53d1\u5149\u6cd5\u548c\u4e73\u80f6\u51dd\u96c6\u8bd5\u9a8c\u3002<\/p>\n

COVID-19 \u65f6\u4ee3\u51dd\u8840\u5b9e\u9a8c\u5ba4\u9762\u4e34\u7684\u6311\u6218<\/h2>\n

\u7531\u4e8e\u4e0e\u8840\u6813\u5f62\u6210\u5bc6\u5207\u76f8\u5173\uff0cCOVID-19 \u65e0\u7591\u7ed9\u60a3\u8005\u7684\u8bca\u65ad\u548c\u7ba1\u7406\u5e26\u6765\u4e86\u8bf8\u591a\u6311\u6218<\/a>\u3002\u5728\u75ab\u60c5\u521d\u671f\uff0c\u5176\u4e2d\u4e00\u4e2a\u6311\u6218\u662f\u4e86\u89e3 COVID-19 \u60a3\u8005\u7684\u75c5\u7406\u751f\u7406\u673a\u5236\u6216\u8840\u6813\u5f62\u6210\u7684\u4f5c\u7528\u3002\u56e0\u6b64\uff0c\u5982\u4f55\u5bf9\u9ad8\u5371\u4eba\u7fa4\u8fdb\u884c\u5206\u5c42\u4ee5\u53ca\u6297\u51dd\u6cbb\u7597\u5728\u8be5\u4eba\u7fa4\u4e2d\u7684\u4f5c\u7528\u4e00\u76f4\u662f\u4e00\u4e2a\u96be\u9898\u3002<\/p>\n

\u53e6\u4e00\u9879\u8bca\u65ad\u6311\u6218\u662f\u8840\u7ba1\u5185\u51dd\u8840\u9176\u539f\u6fc0\u6d3b\u75c7 (VITT)\u3002\u867d\u7136\u6297 PF4 \u6297\u4f53\u68c0\u6d4b\u5df2\u5e7f\u6cdb\u5e94\u7528\u4e8e\u809d\u7d20\u8bf1\u5bfc\u7684\u8840\u5c0f\u677f\u51cf\u5c11\u75c7 (HIT) \u7684\u8bca\u65ad\uff0c\u4f46\u5176\u5728 VITT \u60a3\u8005\u4e2d\u7684\u5e94\u7528\u548c\u654f\u611f\u6027\u5374\u622a\u7136\u4e0d\u540c\u3002\u9664\u4e86\u68c0\u6d4b\u6297 PF4 \u6297\u4f53\u5916\uff0c\u8fd8\u5f00\u53d1\u4e86\u5176\u4ed6\u68c0\u6d4b\u65b9\u6cd5\u6765\u786e\u8ba4\u662f\u5426\u5b58\u5728\u6fc0\u6d3b\u8840\u5c0f\u677f\u7684\u6297\u4f53 [2]\u3002<\/p>\n

\u8fd9\u4e00\u6311\u6218\u4fc3\u4f7f\u4eba\u4eec\u5229\u7528\u73b0\u6709\u8d44\u6e90\u5f00\u53d1\u5176\u4ed6\u68c0\u6d4b\u65b9\u6cd5\uff0c\u4f8b\u5982\u809d\u7d20\u8bf1\u5bfc\u8840\u5c0f\u677f\u805a\u96c6\u8bd5\u9a8c (HIPAA)\u3002\u4f5c\u4e3a HIPAA \u8bd5\u9a8c\u7684\u6539\u8fdb\uff0c\u7814\u7a76\u4eba\u5458\u5f00\u53d1\u4e86\u4e00\u79cd\u8840\u5c0f\u677f\u56e0\u5b50 4 \u8bf1\u5bfc\u7684\u8840\u5c0f\u677f\u805a\u96c6\u8bd5\u9a8c\uff0c\u65e8\u5728\u66f4\u597d\u5730\u786e\u5b9a VITT \u7684\u75c5\u56e0\uff0c\u6216\u8005\u66f4\u786e\u5207\u5730\u8bf4\uff0c\u662f\u8bca\u65ad\u3002\u5b9e\u9a8c\u5ba4\u4e2d\u5df2\u91c7\u7528\u6d41\u5f0f\u7ec6\u80de\u672f\u68c0\u6d4b\u8840\u5c0f\u677f\u6d3b\u5316\u6216\u6297\u4f53\u3002\u8fd9\u4e9b\u68c0\u6d4b\u65b9\u6cd5\u867d\u7136\u5b9e\u7528\uff0c\u4f46\u5f00\u53d1\u8d77\u6765\u4e5f\u9887\u5177\u6311\u6218\u6027\uff0c\u4e0d\u8fc7\u5b83\u4eec\u5df2\u88ab\u8bc1\u5b9e\u53ef\u7528\u4e8e VITT \u7684\u8bca\u65ad\u3002<\/p>\n

\u65b0\u4e00\u4ee3\u51dd\u8840\u8bca\u65ad<\/h2>\n

COVID-19 \u8bf1\u53d1\u7684\u51dd\u8840\u529f\u80fd\u969c\u788d\u662f\u4e00\u79cd\u72ec\u7279\u7684\u75be\u75c5\uff0c\u5176\u7279\u5f81\u662f D-\u4e8c\u805a\u4f53\u663e\u8457\u5347\u9ad8\u3002COVID-19 \u4e0e\u5fae\u8840\u7ba1\u548c\u5927\u8840\u7ba1\u8840\u6813\u5f62\u6210\u7684\u9ad8\u98ce\u9669\u4ee5\u53ca\u6297\u51dd\u6cbb\u7597\u5931\u8d25\u7387\u5347\u9ad8\u76f8\u5173\u3002\u4e0e\u4f20\u7edf\u8113\u6bd2\u75c7\u4e0d\u540c\uff0c\u6297\u51dd\u6cbb\u7597\u5728COVID-19 \u7684\u6cbb\u7597<\/a>\u4e2d\u53d1\u6325\u7740\u5173\u952e\u4f5c\u7528\uff0c\u5bf9\u63d0\u9ad8\u751f\u5b58\u7387\u6709\u79ef\u6781\u5f71\u54cd\u3002<\/p>\n

\u751f\u7269\u6807\u5fd7\u7269\u548c\u5404\u79cd\u8bc4\u5206\u7cfb\u7edf\u53ef\u80fd\u6709\u52a9\u4e8e\u5c06\u60a3\u8005\u5206\u8bca\u5230\u4e0d\u540c\u7684\u98ce\u9669\u7c7b\u522b\uff0c\u4ee5\u4fbf\u8fdb\u884c\u6297\u51dd\u6cbb\u7597\uff0c\u4ee5\u53ca\u8bca\u65ad COVID-19 \u75ab\u82d7\u63a5\u79cd\u540e\u7684\u8840\u6813\u3002<\/p>\n

\u53c2\u8003:<\/em>
\n[1]<\/a> ISTH experts explain new Blood Clotting phenomenon in hospitalized COVID-19 patients.<\/p>\n

[2]<\/a>\u00a0Scully, M. et al (2021). Pathologic Antibodies to Platelet Factor 4 after ChAdOx1 nCoV-19 Vaccination. New England Journal of Medicine. 384.pp2202-2211.<\/p>\n","protected":false},"excerpt":{"rendered":"

\u611f\u67d3\u65b0\u51a0\u75c5\u6bd2\u4e0e\u8840\u6813\u5f62\u6210\u6709\u5173\uff0c\u8840\u6813\u53ef\u80fd\u7d2f\u53ca\u9759\u8109\u548c\u52a8\u8109\u3002\u56e0\u611f\u67d3\u65b0\u51a0\u75c5\u6bd2\u800c\u4f4f\u9662\u7684\u60a3\u8005\u8840\u6813\u98ce\u9669\u6700\u9ad8\uff0c\u666e\u901a\u75c5\u623f\u60a3\u8005\u7684\u8840\u6813\u53d1\u751f\u7387\u7ea6\u4e3a 5%\uff0c\u800c\u91cd\u75c7\u76d1\u62a4\u5ba4 (ICU) \u63a5\u53d7\u751f\u547d\u652f\u6301\u7684\u60a3\u8005\u8840\u6813\u53d1\u751f\u7387\u9ad8\u8fbe 20%\u3002\u65e0\u9700\u4f4f\u9662\u7684\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3\u8005\u8840\u6813\u98ce\u9669\u8f83\u4f4e\uff0c\u7ea6\u4e3a 1% [1]\u3002 \u867d\u7136\u975e\u5e38\u7f55\u89c1\uff0c\u4f46\u63a5\u79cd\u817a\u75c5\u6bd2\u75ab\u82d7\u4e5f\u53ef\u80fd\u5bfc\u81f4\u8840\u6813\uff0c\u8fd9\u79cd\u60c5\u51b5\u79f0\u4e3a\u75ab\u82d7\u8bf1\u5bfc\u7684\u8840\u6813\u6027\u8840\u5c0f\u677f\u51cf\u5c11\u75c7 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