{"id":141333,"date":"2024-02-21T09:10:17","date_gmt":"2024-02-21T09:10:17","guid":{"rendered":"https:\/\/labinsights.com\/acf_article\/%e7%94%9f%e7%89%a9%e6%a8%99%e8%aa%8c%e7%89%a9%e5%9c%a8%e6%95%97%e8%a1%80%e7%97%87%e7%ae%a1%e7%90%86%e4%b8%ad%e7%9a%84%e4%bd%9c%e7%94%a8\/"},"modified":"2026-02-27T10:40:09","modified_gmt":"2026-02-27T10:40:09","slug":"the-role-of-biomarkers-in-management-of-sepsis","status":"publish","type":"acf_article","link":"https:\/\/labinsights.com\/zhtw\/disease-area\/sepsis\/the-role-of-biomarkers-in-management-of-sepsis\/","title":{"rendered":"\u751f\u7269\u6a19\u8a8c\u7269\u5728\u6557\u8840\u75c7\u7ba1\u7406\u4e2d\u7684\u4f5c\u7528"},"content":{"rendered":"<p class=\"text-align-justify\"><a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2492881\" target=\"_blank\" rel=\"noopener\">\u6557\u8840\u75c7\u53ca\u6557\u8840\u6027\u4f11\u514b(Sepsis-3)<\/a> 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1500 gm\uff09\u7684\u53ef\u7372\u5f97\u8840\u6db2\u91cf\u70ba\u7d040.5-1 ml\uff0c\u4f4e\u542b\u91cf\u83cc\u8840\u75c7\u4e4b\u767e\u5206\u6bd4\u9ad8\u4e14\u967d\u6027\u8840\u57f9\u990a\u6301\u7e8c\u6642\u9593\u9577\uff0c\u56e0\u6b64\u5df2\u7d93\u6e2c\u8a66\u4e86\u82e5\u5e72\u5f15\u6578\u5728\u8a3a\u65b7\u65b0\u751f\u5152\u6557\u8840\u75c7\u4e2d\u7684\u6e96\u78ba\u6027\uff0c\u5305\u62ec\u964d\u9223\u7d20\u539f\u3001\u8102\u591a\u91a3\u7d50\u5408\u86cb\u767d\u3001presepsin\u53ca\u4ecb\u767d\u7d20-6\u3002<\/p>\n<p class=\"text-align-justify\">IL-6\u70ba\u53c3\u8207\u514d\u75ab\u53cd\u61c9\u3001\u9020\u8840\u53ca\u6025\u6027\u671f\u53cd\u61c9\u4e4b\u591a\u529f\u80fd\u7d30\u80de\u6fc0\u7d20\u3002\u56e0\u61c9\u65bc\u611f\u67d3\uff0cIL-6\u589e\u5f37IgM\u3001IgG\u53caIgA\u4e4b\u7522\u751f\u4ee5\u53ca\u8f14\u52a9T\u7d30\u80de\u4e4b\u589e\u6b96\uff0c\u5f9e\u800c\u5728\u5bbf\u4e3b\u9632\u79a6\u6a5f\u5236\u4e2d\u767c\u63ee\u95dc\u9375\u4f5c\u7528\u3002\u66b4\u9732\u65bc\u7d30\u83cc\u5167\u6bd2\u7d20\u5f8c\uff0cIL-6\u6fc3\u5ea6\u5728\u5305\u62ecC\u53cd\u61c9\u86cb\u767d(CRP)\u5728\u5167\u7684\u6025\u6027\u671f\u53cd\u61c9\u7269\u4e4b\u524d\u5347\u9ad8\u3002\u53ef\u5728\u81cd\u5e36\u8840\u6216\u8840\u6e05\u4e2d\u6e2c\u5b9aIL-6\uff0c\u5f97\u5230\u4e0d\u540c\u7684\u8a3a\u65b7\u6e96\u78ba\u6027\u3002\u81cd\u5e36\u8840IL-6\u5c0d\u65e9\u671f\u767c\u4f5c\u6557\u8840\u75c7\u7684\u9748\u654f\u5ea6\u70ba87-100%\u3002\u8840\u6e05IL-6\u5c0d\u65e9\u671f\u767c\u4f5c\u6557\u8840\u75c7\u4e4b\u8a3a\u65b7\u7684\u654f\u611f\u5ea6\u70ba75-85%\u4e14\u7279\u7570\u6027\u70ba72.8-88%\uff0c\u5c0d\u665a\u767c\u6557\u8840\u75c7\u4e4b\u654f\u611f\u5ea6\u70ba80-93.8%\u4e14\u7279\u7570\u6027\u70ba80-96%\uff0c\u5f9e\u800c\u512a\u65bcCRP\u3002\u5728\u6297\u751f\u7d20\u6cbb\u7642\u671f\u9593\uff0c\u8840\u6e05IL-6\u6fc3\u5ea6\u8fc5\u901f\u4e0b\u964d\u81f3\u7121\u6cd5\u6aa2\u6e2c\u5230\u7684\u503c\u3002IL-6\u7684\u9ad8\u9748\u654f\u5ea6\u548c\u9670\u6027\u9810\u6e2c\u503c\u4f7f\u5176\u8207\u9ad8\u7279\u7570\u6027CRP\u7d50\u5408\u6210\u70ba\u8a3a\u65b7\u65b0\u751f\u5152\u6557\u8840\u75c7\u7684\u5408\u9069\u5019\u9078\u85e5\u7269\u3002<\/p>\n<p><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone size-full wp-image-125419\" src=\"https:\/\/labinsights.com\/wp-content\/uploads\/2024\/02\/sepsis-5.jpg\" alt=\"\" width=\"1771\" height=\"1121\" title=\"\" srcset=\"https:\/\/labinsights.com\/app\/uploads\/2024\/02\/sepsis-5.jpg 1771w, https:\/\/labinsights.com\/app\/uploads\/2024\/02\/sepsis-5-302x191.jpg 302w, https:\/\/labinsights.com\/app\/uploads\/2024\/02\/sepsis-5-1024x648.jpg 1024w, https:\/\/labinsights.com\/app\/uploads\/2024\/02\/sepsis-5-768x486.jpg 768w, https:\/\/labinsights.com\/app\/uploads\/2024\/02\/sepsis-5-1536x972.jpg 1536w\" sizes=\"(max-width: 1771px) 100vw, 1771px\" \/><\/p>\n<p class=\"text-align-justify\"><em>\u57161\uff1a\u4ecb\u767d\u7d20-6\u53caC\u53cd\u61c9\u86cb\u767d\u53ca\u5176\u5728\u6557\u8840\u75c7\u4e2d\u96a8\u6642\u9593\u63a8\u79fb\u7684\u767c\u5c55\u3002\u5728\u7b2c1\u5929(a)\u53ca\u7b2c7\u5929(b)\u5f8c\uff0c\u7d93\u57f9\u990a\u78ba\u8a8d\u7684\u6557\u8840\u75c7\u4e2d\u4e4b\u8840\u6e05\u4ecb\u767d\u7d20-6\u53caC\u53cd\u61c9\u86cb\u767d(CRP)\u3002<\/em><\/p>\n<p class=\"text-align-justify\">\u5982\u57161\u6240\u793a\uff0c\u5728DOL 1\uff08\u751f\u547d\u7b2c1\u5929\uff09\u57f9\u990a\u78ba\u8a8d\u7684\u6557\u8840\u75c7\u60c5\u6cc1\u4e0b\uff0c\u8840\u6e05IL-6\u958b\u59cb\u9ad8\u5ea6\u5347\u9ad8\uff0c\u800cCRP\u9700\u898148\u5c0f\u6642\u624d\u80fd\u9054\u5230\u5176\u5cf0\u503c\u3002\u57fa\u65bc\u8840\u6e05IL-6\u7684\u9ad8\u6e96\u78ba\u6027\uff0c\u6211\u5011\u5f97\u51fa\u7d50\u8ad6\uff0c\u5728DOL 1\u4e0a\u78ba\u5b9a\u7684IL-6\u5728\u5148\u5929\u6027\u6557\u8840\u75c7\u7684\u8a3a\u65b7\u4e2d\u975e\u5e38\u6709\u5e6b\u52a9\u3002\u4ea6\u5982\u57161\u6240\u793a\uff0c\u5728DOL 7\u5f8c\u7684\u57f9\u990a\u7269\u78ba\u8a8d\u6557\u8840\u75c7\u767c\u4f5c\u4e2d\uff0c\u8840\u6e05IL-6\u5728CRP\u4e4b\u524d\u589e\u52a024\u81f348\u5c0f\u6642\u3002\u9019\u4f7f\u5f97\u8840\u6e05IL-6\u6210\u70ba\u5728\u51fa\u751f\u5f8c\u7b2c\u4e00\u9031\u6557\u8840\u75c7\u75c5\u4f8b\u4e2d\u6700\u6e96\u78ba\u548c\u7b2c\u4e00\u500b\u4e0a\u5347\u7684\u5be6\u9a57\u5ba4\u5f15\u6578\u3002Tzialla\u7b49\u4eba\u5831\u5c0e\u7d30\u80de\u6fc0\u7d20\u542b\u91cf\u8fc5\u901f\u8b8a\u5316\uff0c\u5373\u4f7f\u5728\u6025\u6027\u671f\u53cd\u61c9\u7269\u4e4b\u524d\u4ea6\u5982\u6b64\u3002<\/p>\n<p class=\"text-align-justify\">\u57fa\u65bc\u8840\u6e05IL-6\u4e4b\u9ad8\u6e96\u78ba\u5ea6\uff0c\u5c24\u5176\u662f\u6975\u9ad8\u9670\u6027\u9810\u6e2c\u503c\uff0c\u6211\u5011\u5f97\u51fa\u7d50\u8ad6\uff0c\u8840\u6e05IL-6\u5728\u8a3a\u65b7\u65b0\u751f\u5152\u53ca\u65e9\u7522\u5152\u6557\u8840\u75c7\u4e2d\u975e\u5e38\u6709\u5e6b\u52a9\u3002\u6b64\u5916\uff0cIL-6\u5728\u958b\u59cb\u6709\u6548\u7684\u6297\u751f\u7d20\u6cbb\u7642\u5f8c\u8fc5\u901f\u4e0b\u964d\uff0c\u9019\u5141\u8a31\u5feb\u901f\u76e3\u6e2c\u6297\u751f\u7d20\u6cbb\u7642\u4e26\u53ca\u6642\u905e\u589e\u6216\u964d\u7d1a\u6cbb\u7642[4]\u3002<\/p>\n<h2 class=\"text-align-justify\" style=\"font-family: Inter !important; font-weight: 500 !important; font-size: 28px !important; line-height: 36px !important; letter-spacing: 0px !important;\">\u7d50\u8ad6<\/h2>\n<p class=\"text-align-justify\">\u6557\u8840\u75c7\u662f\u4e00\u7a2e\u5371\u53ca\u751f\u547d\u7684\u75be\u75c5\uff0c\u4e26\u4e14\u662f\u5165\u4f4fICU\u7684\u6700\u5e38\u898b\u539f\u56e0\u4e4b\u4e00\u3002\u65e9\u671f\u8a3a\u65b7\u53ca\u9069\u7576\u7ba1\u7406\u5c0d\u65bc\u964d\u4f4e\u6557\u8840\u75c7\u4e4b\u6b7b\u4ea1\u7387\u662f\u5fc5\u8981\u7684\u3002\u7136\u800c\uff0c\u751f\u7406\u53cd\u61c9\u5c0d\u611f\u67d3\u7684\u500b\u9ad4\u5dee\u7570\u5f88\u5927\uff0c\u4e14\u6557\u8840\u75c7\u7684\u5fb5\u8c61\u548c\u75c7\u72c0\u6c92\u6709\u7279\u7570\u6027\uff0c\u4f7f\u5f97\u65e9\u671f\u8a3a\u65b7\u5f88\u56f0\u96e3\u3002\u56e0\u6b64\uff0c\u5df2\u7d93\u7814\u7a76\u4e86\u8a31\u591a\u7528\u65bc\u8a3a\u65b7\u6557\u8840\u75c7\u7684\u6f5b\u5728\u751f\u7269\u6a19\u7c64\u3002\u9019\u4e9b\u5206\u5b50\u4e3b\u8981\u53c3\u8207\u5c0d\u611f\u67d3\u7684\u5148\u5929\u514d\u75ab\u53cd\u61c9\u7684\u521d\u59cb\u767c\u75c5\u6a5f\u5236\uff0c\u5728\u8a31\u591a\u60c5\u6cc1\u4e0b\uff0c\u5b83\u5011\u986f\u793a\u51fa\u9810\u5f8c\u50f9\u503c\u4ee5\u53ca\u8a3a\u65b7\u50f9\u503c\u3002\u6557\u8840\u75c7\u7684\u9810\u5f8c\u6a19\u8a8c\u7269\u901a\u5e38\u8207\u6557\u8840\u75c7\u5f15\u8d77\u7684\u5668\u5b98\u529f\u80fd\u969c\u7919\u6709\u95dc\uff0c\u4e26\u4e14\u6b63\u5728\u5617\u8a66\u958b\u767c\u9776\u5411\u9019\u4e9b\u9810\u5f8c\u751f\u7269\u6a19\u8a8c\u7269\u7684\u6557\u8840\u75c7\u6cbb\u7642\u5291\u3002\u6b64\u5916\uff0c\u6700\u8fd1\u7684\u6280\u8853\u9032\u6b65\u5df2\u7d93\u5c0e\u81f4\u958b\u767c\u65b0\u578b\u751f\u7269\u6a19\u8a8c\uff0c\u8af8\u5982\u5fae\u751f\u7269\u7d44\u53ca\u975e\u7de8\u78bcRNA\u3002\u5df2\u77e5\u8178\u9053\u5fae\u751f\u7269\u7fa4\u5728\u514d\u75ab\u7cfb\u7d71\u7684\u767c\u80b2\u548c\u6210\u719f\u4ee5\u53ca\u91dd\u5c0d\u75c5\u539f\u9ad4\u7684\u4fdd\u8b77\u4e2d\u767c\u63ee\u91cd\u8981\u4f5c\u7528\u3002\u56e0\u6b64\uff0c\u8178\u9053\u751f\u614b\u5931\u8abf\u88ab\u8a8d\u70ba\u662f\u6557\u8840\u75c7\u767c\u5c55\u53ca\u9032\u5c55\u7684\u5f37\u5927\u751f\u7269\u6a19\u8a8c\u3002\u5305\u62ecmiRNA\u7684\u975e\u7de8\u78bcRNA\u548c\u9577\u975e\u7de8\u78bcRNA\u4ee5\u5404\u7a2e\u65b9\u5f0f\u8abf\u7bc0\u57fa\u56e0\u8868\u73fe\uff0c\u4f46\u5b83\u5011\u5728\u6557\u8840\u75c7\u767c\u75c5\u6a5f\u5236\u4e2d\u7684\u529f\u80fd\u548c\u6a5f\u5236\u5c1a\u4e0d\u5b8c\u5168\u6e05\u695a\u3002<\/p>\n<p class=\"text-align-justify\">\u672a\u4f86\u7684\u81e8\u5e8a\u4f7f\u7528\u5c07\u9700\u8981\u9032\u4e00\u6b65\u8a55\u4f30\uff0c\u5305\u62ec\u9019\u4e9b\u65b0\u751f\u7269\u6a19\u8a8c\u5728\u6557\u8840\u75c7\u767c\u75c5\u6a5f\u5236\u4e2d\u7684\u4f5c\u7528\u4ee5\u53ca\u958b\u767c\u7528\u65bc\u5206\u6790\u9019\u4e9b\u65b0\u751f\u7269\u6a19\u8a8c\u7684\u6700\u4f73\u6b78\u4e00\u5316\u7b56\u7565[5]\u3002<\/p>\n<p class=\"text-align-justify\"><em>\u53c3\u8003\u6587\u737b\uff1a<\/em><\/p>\n<p class=\"text-align-justify\"><a href=\"https:\/\/www.safetyandquality.gov.au\/sites\/default\/files\/2022-06\/sepsis_clinical_care_standard_2022.pdf\" target=\"_blank\" rel=\"noopener\">[1] <\/a>\u6557\u8840\u75c7\u81e8\u5e8a\u7167\u8b77\u6a19\u6e962022<\/p>\n<p class=\"text-align-justify\"><a href=\"https:\/\/www.healthdata.org\/research-analysis\/gbd\" target=\"_blank\" rel=\"noopener\">[2]<\/a> \u5168\u7403\u75be\u75c5\u8ca0\u64d4\u7814\u7a76<\/p>\n<p class=\"text-align-justify\"><a href=\"https:\/\/jtd.amegroups.org\/article\/view\/34840\/html\" target=\"_blank\" rel=\"noopener\">[3]<\/a>\u00a0Gregoriano\uff0cC.\u7b49\u4eba(2020) \u300c\u964d\u9223\u7d20\u539f\u5728\u5728\u6557\u8840\u75c7\u7ba1\u7406\u4e2d\u7684\u61c9\u7528\u89d2\u8272\u300d\uff0c\u80f8\u8154\u75be\u75c5\u96dc\u8a8c\uff0c12(S1)\u2026\u2026doi\uff1a10.21037\/jtd.2019.11.63\u3002<\/p>\n<p class=\"text-align-justify\"><a href=\"https:\/\/www.nature.com\/articles\/s41390-022-02329-9\" target=\"_blank\" rel=\"noopener\">[4]<\/a>\u00a0Kung\uff0cE.\u7b49\u4eba(2022) \u300c\u8840\u6e05\u4ecb\u767d\u7d20-6\u7528\u65bc\u57f9\u990a\u8b49\u5be65\u4e4b\u65b0\u751f\u5152\u6557\u8840\u7389\u503c\u300d\uff0cPediatric Research\uff0c93(7)\uff0cpp. 1969-1974\u3002 doi\uff1a10.1038\/s41390-022-02329-9\u3002<\/p>\n<p class=\"text-align-justify\">[5]\u00a0Kim\uff0cM.-H.\u53caChoi\uff0cJ.-H. (2020) \u300c\u6557\u8840\u75c7\u751f\u7269\u6a19\u8a8c\u7269\u7684\u6700\u65b0\u7814\u7a76\u9032\u5c55\u300d\uff0c\u611f\u67d3\u8207\u5316\u5b78\u6cbb\u7642\uff0c52(1)\uff0c\u7b2c1\u9801\u3002doi\uff1a10.3947\/ic.2020.52.1.1\u3002<\/p>\n<hr \/>\n<p class=\"text-align-justify\"><em>\u672c\u6587\u6700\u521d\u520a\u767b\u5728 <a href=\"https:\/\/diagnostics.roche.com\/au\/en_gb\/article-listing\/role_biomarkers_management_sepsis.html\" target=\"_blank\" rel=\"noopener\">\u6fb3\u6d32\u7f85\u6c0f\u8a3a\u65b7<\/a><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6557\u8840\u75c7\u53ca\u6557\u8840\u6027\u4f11\u514b(Sepsis-3) \u4e4b\u7b2c\u4e09\u7248\u570b\u969b\u5171\u8b58\u5b9a\u7fa9\u5c07\u6557\u8840\u75c7\u5b9a\u7fa9\u70ba\u300c\u7531\u5bbf\u4e3b\u5c0d\u611f\u67d3\u53cd\u61c9\u5931\u8abf\u5f15\u8d77\u7684\u5371\u53ca\u751f\u547d\u7684\u5668\u5b98\u529f\u80fd\u969c\u7919\u300d\u3002 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