{"id":141339,"date":"2023-12-04T06:30:13","date_gmt":"2023-12-04T06:30:13","guid":{"rendered":"https:\/\/labinsights.com\/acf_article\/%e5%bf%83%e5%8a%9b%e8%a1%b0%e7%ab%ad%e4%b8%ad%e4%b9%8b%e5%87%9d%e8%a1%80%e7%96%be%e6%82%a3%ef%bc%9a%e7%97%85%e7%90%86%e7%94%9f%e7%90%86%e5%ad%b8%e5%8f%8a%e8%87%a8%e5%ba%8a%e7%ae%a1%e7%90%86\/"},"modified":"2026-01-19T07:00:46","modified_gmt":"2026-01-19T07:00:46","slug":"coagulation-disorders-in-heart-failure-pathophysiology-and-clinical-management","status":"publish","type":"acf_article","link":"https:\/\/labinsights.com\/zhtw\/disease-area\/cardiology\/coagulation-disorders-in-heart-failure-pathophysiology-and-clinical-management\/","title":{"rendered":"\u5fc3\u529b\u8870\u7aed\u4e2d\u4e4b\u51dd\u8840\u75be\u60a3\uff1a\u75c5\u7406\u751f\u7406\u5b78\u53ca\u81e8\u5e8a\u7ba1\u7406"},"content":{"rendered":"<h2 style=\"font-family: Inter !important; font-weight: 500 !important; font-size: 28px !important; line-height: 36px !important; letter-spacing: 0px !important;\">\u5fc3\u529b\u8870\u7aed\u6240\u81f4\u4e4b\u8840\u6db2\u51dd\u56fa\u75be\u60a3<\/h2>\n<p class=\"text-align-justify\">\u5fc3\u529b\u8870\u7aed(HF)\u662f\u4e00\u7a2e\u81e8\u5e8a\u75c7\u5019\u7fa4\uff0c\u7531\u5fc3\u81df\u7684\u7d50\u69cb\u6216\u529f\u80fd\u969c\u7919\u5f15\u8d77\uff0c\u5c0e\u81f4\u904b\u52d5\u6216\u4f11\u606f\u671f\u9593\u5fc3\u5167\u58d3\u5347\u9ad8\u548c\/\u6216\u5fc3\u8f38\u51fa\u91cf\u4e0d\u8db3\u3002\u8a72\u75c5\u75c7\u8207\u52d5\u8108\u53ca\u975c\u8108\u8840\u6813\u4e8b\u4ef6\u98a8\u96aa\u589e\u52a0\u6709\u95dc\u3002\u81e8\u5e8a\u91ab\u5e2b\u5c0d\u9019\u500b\u554f\u984c\u7684\u66f4\u591a\u8a8d\u8b58\uff0c\u4ee5\u53ca\u66f4\u591a\u7684\u7814\u7a76\u548c\u66f4\u660e\u78ba\u7684\u7ba1\u7406\u6307\u5357\uff0c\u53ef\u4ee5\u652f\u63f4\u5c0dHF\u60a3\u8005\u4e2d\u51dd\u8840\u969c\u7919\u7684\u66f4\u597d\u8a3a\u65b7\u548c\u6cbb\u7642\u3002<\/p>\n<h2 class=\"text-align-justify\" style=\"font-family: Inter !important; font-weight: 500 !important; font-size: 28px !important; line-height: 36px !important; letter-spacing: 0px !important;\">HF\u4e2d\u51dd\u8840\u75be\u60a3\u4e4b\u75c5\u7406\u751f\u7406<\/h2>\n<p class=\"text-align-justify\">\u6839\u64da\u5de6\u5fc3\u5ba4\u5c04\u51fa\u5206\u7387(LVEF)\uff0cHF\u5206\u70ba3\u500b\u4e9e\u578b\uff1a\u5c04\u51fa\u5206\u6578\u964d\u4f4e\u7684HF (HFrEF)\uff1b\u5c04\u51fa\u5206\u6578\u8f15\u5ea6\u964d\u4f4e\u7684HF (HFmrEF)\uff1b\u5c04\u51fa\u5206\u6578\u4fdd\u7559\u7684HF (HFpEF)\u3002\u6bcf\u7a2e\u4e9e\u578b\u90fd\u6709\u7279\u5b9a\u7684\u81e8\u5e8a\u7279\u5fb5\u548c\u5e38\u898b\u7684\u5408\u4f75\u75be\u75c5\uff0c\u5305\u62ec\u8840\u6813\u6813\u585e\u4f75\u767c\u75c7\u7684\u53ef\u8b8a\u98a8\u96aa[2].<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/labinsights.com\/wp-content\/uploads\/2025\/05\/coagulation_disorders_in_heart_failure_-_pathophysiology_and_clinical_management_image_1_ru-RU.jpg\" alt=\"coagulation_disorders_in_heart_failure \" title=\"\"><\/p>\n<p class=\"text-align-justify\">HF\u53ca\u8840\u6813\u5f62\u6210\u901a\u5e38\u56e0\u591a\u7a2e\u539f\u56e0\u95dc\u806f\u3002\u9996\u5148\uff0c\u7f3a\u8840\u6027\u5fc3\u81df\u75c5\uff08HF\u4e4b\u4e3b\u8981\u539f\u56e0\uff09\u6613\u65bc\u7d93\u7531\u8840\u5c0f\u677f\u6d3b\u5316\u53ca\u805a\u96c6\u5f62\u6210\u52d5\u8108\u8840\u6813\u3002\u975c\u8108\u8840\u6813\u6813\u585e(VTE)\u5728HF\u4e2d\u4e5f\u5f88\u5e38\u898b\uff0c\u5c0e\u81f4\u5fc3\u81df\u6813\u585e\u6027\u4e2d\u98a8\u53ca\u731d\u6b7b\u98a8\u96aa\u5347\u9ad8\u3002\u7576HF\u60a3\u8005\u60a3\u6709\u5176\u4ed6\u5408\u4f75\u75c7\u8af8\u5982\u5fc3\u623f\u986b\u52d5(AF)\u6642\uff0c\u8840\u6813\u6813\u585e\u53ca\u4e2d\u98a8\u7684\u98a8\u96aa\u7279\u5225\u9ad8\u3002\u767c\u73fe\u8d85\u904e\u4e00\u534a\u65b0\u8a3a\u65b7HF\u7684\u60a3\u8005\u60a3\u6709AF\uff0cAF\u53caHF\u7684\u5b58\u5728\u9810\u793a\u8457\u66f4\u5927\u7684\u6b7b\u4ea1\u98a8\u96aa\u3002<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/labinsights.com\/wp-content\/uploads\/2025\/05\/coagulation_disorders_in_heart_failure_-_pathophysiology_and_clinical_management_image_2_ru-RU.jpg\" alt=\"coagulation_disorders_in_heart_failure \" title=\"\"><\/p>\n<p class=\"text-align-justify\">Virchow\u6c0f\u4e09\u806f\u5fb5\u7684\u6240\u6709\u4e09\u500b\u7d44\u6210\u90e8\u5206\uff08\u5167\u76ae\u529f\u80fd\u969c\u7919\u3001\u8840\u6d41\u505c\u6eef\u53ca\u9ad8\u51dd\u72c0\u614b\uff09\u7684\u7570\u5e38\u6703\u589e\u52a0HF\u60a3\u8005\u5c0d\u8840\u6813\u5f62\u6210\u7684\u6613\u611f\u6027\u3002\u7136\u800c\uff0c\u52d5\u8108\u53ca\u975c\u8108\u8840\u6813\u5f62\u6210\u7684\u75c5\u56e0\u4e0d\u540c\u3002\u52d5\u8108\u51dd\u584a\u5bcc\u542b\u8840\u5c0f\u677f\u4e26\u5728\u9ad8\u526a\u4e0b\u61c9\u529b\u4e0b\u5f62\u6210\uff0c\u800c\u975c\u8108\u51dd\u584a\u5bcc\u542b\u7e96\u7dad\u86cb\u767d\u4e26\u5728\u8f03\u4f4e\u526a\u4e0b\u61c9\u529b\u74b0\u5883\u4e2d\u5f62\u6210\u3002\u7121\u8ad6HF\u7684\u75c5\u56e0\u6216\u5176\u5408\u4f75\u75c7\u5982\u4f55\uff0c\u8840\u5c0f\u677f\u529f\u80fd\u7684\u7834\u58de\u53ca\u5176\u8207HF\u4e2d\u6240\u898b\u51dd\u8840\u7d1a\u806f\u7684\u76f8\u4e92\u4f5c\u7528\u4fc3\u9032\u8840\u6813\u5f62\u6210[2]\u3002<\/p>\n<p class=\"text-align-justify\">\u5118\u7ba1\u8840\u6813\u6813\u585e\u4f75\u767c\u75c7\u901a\u5e38\u4e0d\u88ab\u8996\u70baHF\u60a3\u8005\u7684\u4e3b\u8981\u554f\u984c\uff0c\u4f46\u9019\u7a2e\u60c5\u6cc1\u8207\u5927\u91cf\u51dd\u8840\u969c\u7919\u6709\u95dc[3]\u3002\u4f8b\u5982\uff0c\u5728HF\u8a3a\u65b7\u6216\u5931\u4ee3\u511f\u5f8c\u7684\u7b2c\u4e00\u500b\u6708\uff0c\u4e2d\u98a8\u7684\u767c\u751f\u7387\u8f03\u9ad8\uff0c\u4e26\u4e14\u5728\u6025\u6027\u4e8b\u4ef6\u5f8c6\u500b\u6708\u5167\u964d\u4f4e[4]\u3002HF\u60a3\u8005\u7684\u8840\u6813\u5f62\u6210\u524d\u8868\u578b\u53ef\u80fd\u662f\u7531\u65bc(1)\u6162\u6027\u7f3a\u6c27\u8a98\u5c0e\u7684\u5168\u8eab\u6027\u708e\u75c7\u53cd\u61c9\uff0c(2)\u8840\u6813\u5f62\u6210\u524d\u5206\u5b50\u6fc3\u5ea6\u589e\u52a0\uff0c\u6216(3)\u52d5\u8108\u53ca\u975c\u8108\u5167\u76ae\u529f\u80fd\u969c\u7919\u3002<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/labinsights.com\/wp-content\/uploads\/2025\/05\/coagulation_disorders_in_heart_failure_-_pathophysiology_and_clinical_management_image_3_ru-RU.jpg\" alt=\"coagulation_disorders_in_heart_failure \" title=\"\"><\/p>\n<p class=\"text-align-justify\">\u4ea6\u767c\u73feHF\u70ba\u4e2d\u98a8\u5f8c\u8eab\u969c\u60e1\u5316\u3001\u518d\u6b21\u5165\u9662\u589e\u52a0\u53ca\u6b7b\u4ea1\u7387\u8f03\u9ad8\u7684\u7368\u7acb\u98a8\u96aa\u56e0\u7d20\u3002\u5118\u7ba1\u5982\u6b64\uff0c\u4ecd\u6c92\u6709\u660e\u78ba\u7684\u6307\u5357\u95e1\u8ff0\u6297\u51dd\u53ca\u6297\u8840\u5c0f\u677f\u7642\u6cd5\u5728\u964d\u4f4eHF\u4e2d\u8207\u51dd\u8840\u7570\u5e38\u76f8\u95dc\u7684\u767c\u751f\u7387\u53ca\u6b7b\u4ea1\u7387\u65b9\u9762\u7684\u4f5c\u7528[1]\u3002\u56e0\u6b64\uff0cHF\u4e2d\u8840\u6813\u6813\u585e\u4f75\u767c\u75c7\u98a8\u96aa\u589e\u52a0\u4ee3\u8868\u4e86\u88ab\u4f4e\u4f30\u7684\u81e8\u5e8a\u6311\u6230\uff0c\u56e0\u70baHF\u7684\u7279\u5fb5\u5728\u65bc\u53ef\u80fd\u52a0\u5287\u5176\u767c\u751f\u7387\u53ca\u6b7b\u4ea1\u7387\u7684\u8840\u6813\u5f62\u6210\u524d\u72c0\u614b\u3002<\/p>\n<h2 class=\"text-align-justify\" style=\"font-family: Inter !important; font-weight: 500 !important; font-size: 28px !important; line-height: 36px !important; letter-spacing: 0px !important;\">HF\u4e2d\u51dd\u8840\u75be\u60a3\u4e4b\u81e8\u5e8a\u7ba1\u7406<\/h2>\n<p class=\"text-align-justify\">\u5728HF\u60a3\u8005\u4e2d\uff0c\u5df2\u89c0\u5bdf\u5230\u6d3b\u5316\u51dd\u8840\u53ca\/\u6216\u8840\u5c0f\u677f\u6d3b\u5316\u7684\u6a19\u7c64\u4ee5\u53ca\u5167\u76ae\u529f\u80fd\u969c\u7919\u53ca\u4f4e\u5fc3\u8f38\u51fa\u91cf\u3001\u8207\u7570\u5e38\u8840\u6d41\u53ca\u505c\u6eef\u76f8\u95dc\u7684\u75c5\u6cc1\u3002\u6b64\u5916\uff0c\u5e7e\u7a2e\u5e38\u898b\u5408\u4f75\u75c7\u901a\u5e38\u4f7fHF\u8907\u96dc\u5316\uff0c\u9032\u4e00\u6b65\u589e\u52a0\u4e86\u8840\u6813\u6813\u585e\u98a8\u96aa\u3002<\/p>\n<p class=\"text-align-justify\">\u5c0d\u65bc\u7121\u7981\u5fcc\u75c7\u7684\u6025\u6027HF\u4f4f\u9662\u60a3\u8005\u4ee5\u53ca\u63a5\u53d7\u9577\u671f\u6a5f\u68b0\u5faa\u74b0\u652f\u63f4\u7684\u60a3\u8005\uff0c\u5efa\u8b70\u4f7f\u7528\u4f4e\u5206\u5b50\u91cf\u809d\u7d20\u9810\u9632\u8840\u6813\u6813\u585e[1]\u3002\u5728\u904e\u53bb\u7684\u5341\u5e74\u4e2d\uff0c\u76f4\u63a5\u53e3\u670d\u6297\u51dd\u5291(DOAC)\u4ea6\u5df2\u88ab\u6279\u51c6\u7528\u65bc\u6cbb\u7642\u53ca\u9810\u9632\u975e\u74e3\u819c\u6027AF\u4e2d\u4e4b\u4e2d\u98a8\u53ca\u5168\u8eab\u6027\u6813\u585e(SSE)\u3002\u6b64\u985e\u85e5\u7269\u70ba\u83ef\u6cd5\u6797\u7684\u66ff\u4ee3\u85e5\u7269\uff0c\u51fa\u8840\u98a8\u96aa\u8f03\u4f4e[3]\u3002<\/p>\n<p class=\"text-align-justify\">AF\u53caHF\u60a3\u8005\u4e4b\u6297\u51dd\u5291\u88ab\u5ee3\u6cdb\u8a8d\u70ba\u5c0d\u65bc\u964d\u4f4e\u6b64\u7b49\u60a3\u8005\u4e4b\u9ad8\u8840\u6813\u6813\u585e\u98a8\u96aa\u81f3\u95dc\u91cd\u8981\u3002ESC\u6307\u5357\u5efa\u8b70\u4f7f\u7528DOAC\u800c\u975e\u83ef\u6cd5\u6797\u4f86\u9810\u9632AF\u4e2d\u98a8\uff0c\u56e0\u70ba\u9019\u4e9b\u85e5\u7269\u540c\u6a23\u6709\u6548\uff0c\u4e14\u81e8\u5e8a\u7279\u5fb5\u66f4\u5b89\u5168\u3002\u7136\u800c\uff0cHF\u60a3\u8005\u5728\u96a8\u6a5f\u5c0d\u7167\u8a66\u9a57\u4e2d\u7684\u4ee3\u8868\u6027\u4e0d\u8db3[3]\u3002<\/p>\n<p class=\"text-align-justify\">\u5728AF\u4e4bHF\u60a3\u8005\u4e2d\uff0c\u5728\u814e\u529f\u80fd\u4e4b\u6240\u6709\u6c34\u6e96\u4e0b\uff0c\u8207\u83ef\u6cd5\u6797\u76f8\u6bd4\uff0c\u50cf\u963f\u54cc\u6c99\u73ed\u53ca\u9054\u6bd4\u52a0\u7fa4\uff08\u4f46\u4e0d\u662f\u5229\u4f10\u6c99\u73ed\uff09\u4e4bDOAC\u8207\u7e3d\u51fa\u8840\u53ca\u6b7b\u4ea1\u98a8\u96aa\u8f03\u4f4e\u76f8\u95dc\u3002\u5118\u7ba1DOAC\u6cbb\u7642\u4e4b\u8907\u96dc\u6027\u9060\u4f4e\u65bc\u83ef\u6cd5\u6797\uff0c\u4f46\u5176\u7528\u65bcHF\u60a3\u8005\u4e26\u975e\u4e00\u6210\u4e0d\u8b8a\u4e4b\u4e8b\u3002HF\u60a3\u8005\u4e4b\u814e\u529f\u80fd\u901a\u5e38\u6ce2\u52d5\uff0c\u6709\u6642\u9700\u8981\u8abf\u6574DOAC\u5291\u91cf\uff0c\u4f46\u5728\u5be6\u8e10\u4e2d\u5f88\u5c11\u9032\u884c\u9019\u4e9b\u8abf\u6574\u3002\u5373\u4f7f\u814e\u529f\u80fd\u9069\u5ea6\u4e0b\u964d\u4e5f\u8207\u63a5\u53d7DOAC\u6cbb\u7642\u7684\u60a3\u8005\u51fa\u8840\u98a8\u96aa\u589e\u52a0\u76f8\u95dc\uff0c\u5f37\u8abf\u9700\u8981\u4ed4\u7d30\u76e3\u6e2c\u4e26\u9069\u7576\u8abf\u6574\u5291\u91cf\u3002<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/labinsights.com\/wp-content\/uploads\/2025\/05\/coagulation_disorders_in_heart_failure_-_pathophysiology_and_clinical_management_image_4_ru-RU.jpg\" alt=\"coagulation_disorders_in_heart_failure \" title=\"\"><\/p>\n<p class=\"text-align-justify\">\u6297\u51dd\u8a3a\u6240\u6216\u81e8\u5e8a\u85e5\u5e2b\u7684\u5c08\u79d1\u8b77\u7406\u8207\u6539\u5584\u7684DOAC\u5291\u91cf\u8abf\u6574\u548c\u7d50\u679c\u76f8\u95dc\u3002\u5c0d\u89c0\u5bdf\u5230\u7684\u4e0d\u540c\u90e8\u4f4d\u4e4b\u9593\u8868\u73fe\u7684\u5dee\u7570\u9032\u884c\u9032\u4e00\u6b65\u7814\u7a76\u53ef\u80fd\u70ba\u9032\u4e00\u6b65\u6539\u5584\u63a5\u53d7DOAC\u6cbb\u7642\u7684\u60a3\u8005\u7684\u8b77\u7406\u54c1\u8cea\u63d0\u4f9b\u6a5f\u6703[4]\u3002<\/p>\n<h2 class=\"text-align-justify\" style=\"font-family: Inter !important; font-weight: 500 !important; font-size: 28px !important; line-height: 36px !important; letter-spacing: 0px !important;\">\u9032\u4e00\u6b65\u7814\u7a76\u7684\u9700\u6c42<\/h2>\n<p class=\"text-align-justify\">\u5168\u7403\u60a3\u75c5\u7387\u70ba1%-2%\uff0cHF\u4ee3\u8868\u4e00\u7a2e\u4e3b\u8981\u7684\u5168\u7403\u75be\u75c5\uff0c\u9810\u8a08\u5f71\u97ff\u8d85\u904e800\u842c\u6210\u4eba\uff0c\u4e26\u4e14\u9810\u8a08\u52302030\u5e74\uff0cHF\u76f8\u95dc\u7e3d\u6210\u672c\u5c07\u589e\u52a0\u5230700\u5104\u7f8e\u5143\u3002 \u5118\u7ba1\u6700\u8fd1\u5728HF\u7684\u91ab\u5b78\u7ba1\u7406\u65b9\u9762\u53d6\u5f97\u4e86\u5faa\u8b49\u9032\u5c55\uff0c\u8af8\u5982\u4f75\u5165\u690d\u5165\u5f0f\u5fc3\u81df\u53bb\u98a4\u5668\u548c\u5fc3\u81df\u518d\u540c\u6b65\u6cbb\u7642\uff0c\u4f465\u5e74\u6642\u8207HF\u76f8\u95dc\u7684\u6b7b\u4ea1\u7387\u4ecd\u7136\u5f88\u9ad8\uff0c\u7d04\u70ba50%\u3002<\/p>\n<p class=\"text-align-justify\">\u9451\u65bcHF\u60a3\u8005\u9762\u81e8\u9ad8\u8840\u6813\u6813\u585e\u98a8\u96aa\uff0c\u5c24\u5176\u662f\u5b58\u5728AF\u7684\u60c5\u6cc1\u4e0b\uff0cDOAC\u6cbb\u7642\u4f3c\u4e4e\u662f\u4e00\u7a2e\u964d\u4f4e\u8840\u6813\u6813\u585e\u4e8b\u4ef6\u98a8\u96aa\u7684\u5408\u7406\u65b9\u6cd5\uff0c\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\u7279\u5fb5\u3002\u7136\u800c\uff0c\u7531\u65bc\u7f3a\u4e4f\u5177\u9ad4\u8cc7\u6599\uff0c\u81e8\u5e8a\u6c7a\u7b56\u76ee\u524d\u6839\u64da\u4e00\u822cAF\u7fa4\u9ad4\u4e2d\u5927\u578bRCT\u7684\u8b49\u64da\u9032\u884c\u8abf\u6574\u3002<\/p>\n<p class=\"text-align-justify\">\u5728HF\u4e2d\u4f7f\u7528DOAC\u6642\uff0c\u82e5\u5e72\u91cd\u8981\u554f\u984c\u4ecd\u672a\u89e3\u6c7a\uff0c\u4e14\u9700\u8981\u9032\u4e00\u6b65\u6df1\u5165\u5206\u6790\u3002DOAC\u662f\u5426\u5f71\u97ff\u7279\u5b9a\u7684HF\u7d42\u9ede\uff0c\u8af8\u5982HF\u60e1\u5316\u6216\u4f4f\u9662\uff1f\u6211\u5011\u61c9\u5982\u4f55\u7ba1\u7406\u60a3\u6709\u5408\u4f75\u75c7\u4e4bHF-AF\u60a3\u8005\u7684\u6297\u51dd\u8840\uff1f\u5728HF-AF-CAD\u60a3\u8005\u4e2d\uff0c\u6211\u5011\u61c9\u8a72\u5982\u4f55\u7d44\u5408\u6297\u8840\u5c0f\u677f\u53ca\u6297\u51dd\u5291\uff1f\u6211\u5011\u53ef\u4ee5\u5b89\u5168\u6709\u6548\u5730\u5728LV\u8840\u6813\u6027HFAF\u60a3\u8005\u4e2d\u4f7f\u7528DOAC\u55ce\uff1f\u5c0d\u65bcLV\u8840\u6813\u53caAF\u98a8\u96aa\u589e\u52a0\u7684HF\u60a3\u8005\uff0c\u6211\u5011\u61c9\u4f55\u6642\u958b\u59cbDOAC\u7642\u6cd5\uff1f<\/p>\n<p class=\"text-align-justify\">HF\u4ee3\u8868\u4e00\u7a2e\u7368\u7279\u7684\u81e8\u5e8a\u74b0\u5883\uff0c\u9700\u8981\u9776\u5411\u81e8\u5e8a\u7814\u7a76\u53ca\u5b9a\u88fd\u7642\u6cd5\u4f86\u9650\u5236\u4e0d\u826f\u4e8b\u4ef6\u3002\u6b64\u985e\u7814\u7a76\u5c07\u6709\u52a9\u65bc\u5b9a\u7fa9\u5728\u9f90\u5927HF\u60a3\u8005\u7fa4\u9ad4\u53ca\u55ae\u4e00\u4e0d\u540c\u81e8\u5e8a\u60c5\u5883\u4e2dDOAC\u9078\u64c7\u7684\u81e8\u5e8a\u6c7a\u7b56\u3002[3]<\/p>\n<p class=\"text-align-justify\"><em>*DOAC\uff1a2023\u5e74ISTH SSC\u5efa\u8b70\u6309\u6297\u51dd\u85e5\u7269\u7684\u6295\u4e88\u65b9\u5f0f\u548c\u7279\u7570\u6027\u6a19\u9776\uff08\u4f8b\u5982\uff0c\u53e3\u670d\u56e0\u5b50Xia\u6291\u5236\u5291\u3001\u51dd\u8840\u56e0\u5b50Xia\u6291\u5236\u5291\uff09\u4f86\u63cf\u8ff0\u6297\u51dd\u85e5\u7269\u3002 (5)<\/em><\/p>\n<p class=\"text-align-justify\"><em>\u53c3\u8003\u6587\u737b<\/em>\uff1a <a href=\"https:\/\/onlinejcf.com\/article\/S1071-9164(23)00001-5\/fulltext\" target=\"_blank\" rel=\"noopener\">[1]<\/a>\u00a0SINIARSKI\uff0cA.\u7b49\u4eba(2023) \u300cBlood coagulation disorders in heart failure\uff1aFrom basic science to clinical perspectives\u300d\uff0cJournal of Cardiac Failure\uff0c29(4)\uff0c\u7b2c517-526\u9801\u3002 doi\uff1a10.1016\/j.cardfail.2022.12.012\u3002<\/p>\n<p class=\"text-align-justify\"><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s11897-016-0308-6\" target=\"_blank\" rel=\"noopener\">[2]<\/a>\u00a0Kim\uff0cJ.H.\u7b49\u4eba(2016) \u300cCoagulation abnormalities in heart failure\uff1aPathophysiology and therapeutic implications\u300d\uff0cCurrent Heart Failure Reports\uff0c13(6)\uff0cpp. 319-328\u3002 doi\uff1a10.1007\/s11897-016-0308-6\u3002<\/p>\n<p class=\"text-align-justify\"><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s10741-020-09994-0\" target=\"_blank\" rel=\"noopener\">[3]<\/a>\u00a0Paolillo\uff0cS.\u7b49\u4eba(2020) \u300cDirect oral anticoagulants across the heart failure spectrum\uff1aThe Precision Medicine Era\u300d\uff0cHeart Failure Reviews\uff0c27(1)\uff0c\u7b2c135-145\u9801\u3002 doi\uff1a10.1007\/s10741-020-09994-0\u3002<\/p>\n<p class=\"text-align-justify\"><a href=\"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCOUTCOMES.120.007230\" target=\"_blank\" rel=\"noopener\">[4]<\/a>\u00a0Jackevicius\uff0cC.A.\u7b49\u4eba(2021) \u300cBleeding risk of direct oral anticoagulants in patients with heart failure and atrial fibrillation\u300d\uff0cCirculation\uff1aCardiovascular Quality and Outcomes\uff0c14(2)\u2026\u2026doi\uff1a10.1161\/circoutcomes.120.007230\u3002<\/p>\n<p class=\"text-align-justify\"><a href=\"https:\/\/www.jthjournal.org\/article\/S1538-7836(23)00149-6\/fulltext\" target=\"_blank\" rel=\"noopener\">[5]\u00a0<\/a>Barnes\uff0cG.D.\u7b49\u4eba(2023) \u300cRECOMMENDATION on the nomenclature for anticoagulants\uff1aUpdated communication from the International Society on Thrombosis and Haemostasis Scientific and standardization commitee on the control of anticoagulation\u300d\uff0cJournal of Thrombosis and Haemostasis\uff0c21(5)\uff0c\u7b2c1381-1384\u9801\u3002 doi\uff1a10.1016\/j.jtha.2023.02.008\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5fc3\u529b\u8870\u7aed\u6240\u81f4\u4e4b\u8840\u6db2\u51dd\u56fa\u75be\u60a3 \u5fc3\u529b\u8870\u7aed(HF)\u662f\u4e00\u7a2e\u81e8\u5e8a\u75c7\u5019\u7fa4\uff0c\u7531\u5fc3\u81df\u7684\u7d50\u69cb\u6216\u529f\u80fd\u969c\u7919\u5f15\u8d77\uff0c\u5c0e\u81f4\u904b\u52d5\u6216\u4f11\u606f\u671f\u9593\u5fc3\u5167\u58d3\u5347\u9ad8\u548c\/\u6216\u5fc3\u8f38\u51fa\u91cf\u4e0d\u8db3\u3002\u8a72\u75c5\u75c7\u8207\u52d5\u8108\u53ca\u975c\u8108\u8840\u6813\u4e8b\u4ef6\u98a8\u96aa\u589e\u52a0\u6709\u95dc\u3002\u81e8\u5e8a\u91ab\u5e2b\u5c0d\u9019\u500b\u554f\u984c\u7684\u66f4\u591a\u8a8d\u8b58\uff0c\u4ee5\u53ca\u66f4\u591a\u7684\u7814\u7a76\u548c\u66f4\u660e\u78ba\u7684\u7ba1\u7406\u6307\u5357\uff0c\u53ef\u4ee5\u652f\u63f4\u5c0dHF\u60a3\u8005\u4e2d\u51dd\u8840\u969c\u7919\u7684\u66f4\u597d\u8a3a\u65b7\u548c\u6cbb\u7642\u3002 HF\u4e2d\u51dd\u8840\u75be\u60a3\u4e4b\u75c5\u7406\u751f\u7406 \u6839\u64da\u5de6\u5fc3\u5ba4\u5c04\u51fa\u5206\u7387(LVEF)\uff0cHF\u5206\u70ba3\u500b\u4e9e\u578b\uff1a\u5c04\u51fa\u5206\u6578\u964d\u4f4e\u7684HF (HFrEF)\uff1b\u5c04\u51fa\u5206\u6578\u8f15\u5ea6\u964d\u4f4e\u7684HF (HFmrEF)\uff1b\u5c04\u51fa\u5206\u6578\u4fdd\u7559\u7684HF (HFpEF)\u3002\u6bcf\u7a2e\u4e9e\u578b\u90fd\u6709\u7279\u5b9a\u7684\u81e8\u5e8a\u7279\u5fb5\u548c\u5e38\u898b\u7684\u5408\u4f75\u75be\u75c5\uff0c\u5305\u62ec\u8840\u6813\u6813\u585e\u4f75\u767c\u75c7\u7684\u53ef\u8b8a\u98a8\u96aa[2]. HF\u53ca\u8840\u6813\u5f62\u6210\u901a\u5e38\u56e0\u591a\u7a2e\u539f\u56e0\u95dc\u806f\u3002\u9996\u5148\uff0c\u7f3a\u8840\u6027\u5fc3\u81df\u75c5\uff08HF\u4e4b\u4e3b\u8981\u539f\u56e0\uff09\u6613\u65bc\u7d93\u7531\u8840\u5c0f\u677f\u6d3b\u5316\u53ca\u805a\u96c6\u5f62\u6210\u52d5\u8108\u8840\u6813\u3002\u975c\u8108\u8840\u6813\u6813\u585e(VTE)\u5728HF\u4e2d\u4e5f\u5f88\u5e38\u898b\uff0c\u5c0e\u81f4\u5fc3\u81df\u6813\u585e\u6027\u4e2d\u98a8\u53ca\u731d\u6b7b\u98a8\u96aa\u5347\u9ad8\u3002\u7576HF\u60a3\u8005\u60a3\u6709\u5176\u4ed6\u5408\u4f75\u75c7\u8af8\u5982\u5fc3\u623f\u986b\u52d5(AF)\u6642\uff0c\u8840\u6813\u6813\u585e\u53ca\u4e2d\u98a8\u7684\u98a8\u96aa\u7279\u5225\u9ad8\u3002\u767c\u73fe\u8d85\u904e\u4e00\u534a\u65b0\u8a3a\u65b7HF\u7684\u60a3\u8005\u60a3\u6709AF\uff0cAF\u53caHF\u7684\u5b58\u5728\u9810\u793a\u8457\u66f4\u5927\u7684\u6b7b\u4ea1\u98a8\u96aa\u3002 Virchow\u6c0f\u4e09\u806f\u5fb5\u7684\u6240\u6709\u4e09\u500b\u7d44\u6210\u90e8\u5206\uff08\u5167\u76ae\u529f\u80fd\u969c\u7919\u3001\u8840\u6d41\u505c\u6eef\u53ca\u9ad8\u51dd\u72c0\u614b\uff09\u7684\u7570\u5e38\u6703\u589e\u52a0HF\u60a3\u8005\u5c0d\u8840\u6813\u5f62\u6210\u7684\u6613\u611f\u6027\u3002\u7136\u800c\uff0c\u52d5\u8108\u53ca\u975c\u8108\u8840\u6813\u5f62\u6210\u7684\u75c5\u56e0\u4e0d\u540c\u3002\u52d5\u8108\u51dd\u584a\u5bcc\u542b\u8840\u5c0f\u677f\u4e26\u5728\u9ad8\u526a\u4e0b\u61c9\u529b\u4e0b\u5f62\u6210\uff0c\u800c\u975c\u8108\u51dd\u584a\u5bcc\u542b\u7e96\u7dad\u86cb\u767d\u4e26\u5728\u8f03\u4f4e\u526a\u4e0b\u61c9\u529b\u74b0\u5883\u4e2d\u5f62\u6210\u3002\u7121\u8ad6HF\u7684\u75c5\u56e0\u6216\u5176\u5408\u4f75\u75c7\u5982\u4f55\uff0c\u8840\u5c0f\u677f\u529f\u80fd\u7684\u7834\u58de\u53ca\u5176\u8207HF\u4e2d\u6240\u898b\u51dd\u8840\u7d1a\u806f\u7684\u76f8\u4e92\u4f5c\u7528\u4fc3\u9032\u8840\u6813\u5f62\u6210[2]\u3002 \u5118\u7ba1\u8840\u6813\u6813\u585e\u4f75\u767c\u75c7\u901a\u5e38\u4e0d\u88ab\u8996\u70baHF\u60a3\u8005\u7684\u4e3b\u8981\u554f\u984c\uff0c\u4f46\u9019\u7a2e\u60c5\u6cc1\u8207\u5927\u91cf\u51dd\u8840\u969c\u7919\u6709\u95dc[3]\u3002\u4f8b\u5982\uff0c\u5728HF\u8a3a\u65b7\u6216\u5931\u4ee3\u511f\u5f8c\u7684\u7b2c\u4e00\u500b\u6708\uff0c\u4e2d\u98a8\u7684\u767c\u751f\u7387\u8f03\u9ad8\uff0c\u4e26\u4e14\u5728\u6025\u6027\u4e8b\u4ef6\u5f8c6\u500b\u6708\u5167\u964d\u4f4e[4]\u3002HF\u60a3\u8005\u7684\u8840\u6813\u5f62\u6210\u524d\u8868\u578b\u53ef\u80fd\u662f\u7531\u65bc(1)\u6162\u6027\u7f3a\u6c27\u8a98\u5c0e\u7684\u5168\u8eab\u6027\u708e\u75c7\u53cd\u61c9\uff0c(2)\u8840\u6813\u5f62\u6210\u524d\u5206\u5b50\u6fc3\u5ea6\u589e\u52a0\uff0c\u6216(3)\u52d5\u8108\u53ca\u975c\u8108\u5167\u76ae\u529f\u80fd\u969c\u7919\u3002 \u4ea6\u767c\u73feHF\u70ba\u4e2d\u98a8\u5f8c\u8eab\u969c\u60e1\u5316\u3001\u518d\u6b21\u5165\u9662\u589e\u52a0\u53ca\u6b7b\u4ea1\u7387\u8f03\u9ad8\u7684\u7368\u7acb\u98a8\u96aa\u56e0\u7d20\u3002\u5118\u7ba1\u5982\u6b64\uff0c\u4ecd\u6c92\u6709\u660e\u78ba\u7684\u6307\u5357\u95e1\u8ff0\u6297\u51dd\u53ca\u6297\u8840\u5c0f\u677f\u7642\u6cd5\u5728\u964d\u4f4eHF\u4e2d\u8207\u51dd\u8840\u7570\u5e38\u76f8\u95dc\u7684\u767c\u751f\u7387\u53ca\u6b7b\u4ea1\u7387\u65b9\u9762\u7684\u4f5c\u7528[1]\u3002\u56e0\u6b64\uff0cHF\u4e2d\u8840\u6813\u6813\u585e\u4f75\u767c\u75c7\u98a8\u96aa\u589e\u52a0\u4ee3\u8868\u4e86\u88ab\u4f4e\u4f30\u7684\u81e8\u5e8a\u6311\u6230\uff0c\u56e0\u70baHF\u7684\u7279\u5fb5\u5728\u65bc\u53ef\u80fd\u52a0\u5287\u5176\u767c\u751f\u7387\u53ca\u6b7b\u4ea1\u7387\u7684\u8840\u6813\u5f62\u6210\u524d\u72c0\u614b\u3002 HF\u4e2d\u51dd\u8840\u75be\u60a3\u4e4b\u81e8\u5e8a\u7ba1\u7406 \u5728HF\u60a3\u8005\u4e2d\uff0c\u5df2\u89c0\u5bdf\u5230\u6d3b\u5316\u51dd\u8840\u53ca\/\u6216\u8840\u5c0f\u677f\u6d3b\u5316\u7684\u6a19\u7c64\u4ee5\u53ca\u5167\u76ae\u529f\u80fd\u969c\u7919\u53ca\u4f4e\u5fc3\u8f38\u51fa\u91cf\u3001\u8207\u7570\u5e38\u8840\u6d41\u53ca\u505c\u6eef\u76f8\u95dc\u7684\u75c5\u6cc1\u3002\u6b64\u5916\uff0c\u5e7e\u7a2e\u5e38\u898b\u5408\u4f75\u75c7\u901a\u5e38\u4f7fHF\u8907\u96dc\u5316\uff0c\u9032\u4e00\u6b65\u589e\u52a0\u4e86\u8840\u6813\u6813\u585e\u98a8\u96aa\u3002 \u5c0d\u65bc\u7121\u7981\u5fcc\u75c7\u7684\u6025\u6027HF\u4f4f\u9662\u60a3\u8005\u4ee5\u53ca\u63a5\u53d7\u9577\u671f\u6a5f\u68b0\u5faa\u74b0\u652f\u63f4\u7684\u60a3\u8005\uff0c\u5efa\u8b70\u4f7f\u7528\u4f4e\u5206\u5b50\u91cf\u809d\u7d20\u9810\u9632\u8840\u6813\u6813\u585e[1]\u3002\u5728\u904e\u53bb\u7684\u5341\u5e74\u4e2d\uff0c\u76f4\u63a5\u53e3\u670d\u6297\u51dd\u5291(DOAC)\u4ea6\u5df2\u88ab\u6279\u51c6\u7528\u65bc\u6cbb\u7642\u53ca\u9810\u9632\u975e\u74e3\u819c\u6027AF\u4e2d\u4e4b\u4e2d\u98a8\u53ca\u5168\u8eab\u6027\u6813\u585e(SSE)\u3002\u6b64\u985e\u85e5\u7269\u70ba\u83ef\u6cd5\u6797\u7684\u66ff\u4ee3\u85e5\u7269\uff0c\u51fa\u8840\u98a8\u96aa\u8f03\u4f4e[3]\u3002 AF\u53caHF\u60a3\u8005\u4e4b\u6297\u51dd\u5291\u88ab\u5ee3\u6cdb\u8a8d\u70ba\u5c0d\u65bc\u964d\u4f4e\u6b64\u7b49\u60a3\u8005\u4e4b\u9ad8\u8840\u6813\u6813\u585e\u98a8\u96aa\u81f3\u95dc\u91cd\u8981\u3002ESC\u6307\u5357\u5efa\u8b70\u4f7f\u7528DOAC\u800c\u975e\u83ef\u6cd5\u6797\u4f86\u9810\u9632AF\u4e2d\u98a8\uff0c\u56e0\u70ba\u9019\u4e9b\u85e5\u7269\u540c\u6a23\u6709\u6548\uff0c\u4e14\u81e8\u5e8a\u7279\u5fb5\u66f4\u5b89\u5168\u3002\u7136\u800c\uff0cHF\u60a3\u8005\u5728\u96a8\u6a5f\u5c0d\u7167\u8a66\u9a57\u4e2d\u7684\u4ee3\u8868\u6027\u4e0d\u8db3[3]\u3002 \u5728AF\u4e4bHF\u60a3\u8005\u4e2d\uff0c\u5728\u814e\u529f\u80fd\u4e4b\u6240\u6709\u6c34\u6e96\u4e0b\uff0c\u8207\u83ef\u6cd5\u6797\u76f8\u6bd4\uff0c\u50cf\u963f\u54cc\u6c99\u73ed\u53ca\u9054\u6bd4\u52a0\u7fa4\uff08\u4f46\u4e0d\u662f\u5229\u4f10\u6c99\u73ed\uff09\u4e4bDOAC\u8207\u7e3d\u51fa\u8840\u53ca\u6b7b\u4ea1\u98a8\u96aa\u8f03\u4f4e\u76f8\u95dc\u3002\u5118\u7ba1DOAC\u6cbb\u7642\u4e4b\u8907\u96dc\u6027\u9060\u4f4e\u65bc\u83ef\u6cd5\u6797\uff0c\u4f46\u5176\u7528\u65bcHF\u60a3\u8005\u4e26\u975e\u4e00\u6210\u4e0d\u8b8a\u4e4b\u4e8b\u3002HF\u60a3\u8005\u4e4b\u814e\u529f\u80fd\u901a\u5e38\u6ce2\u52d5\uff0c\u6709\u6642\u9700\u8981\u8abf\u6574DOAC\u5291\u91cf\uff0c\u4f46\u5728\u5be6\u8e10\u4e2d\u5f88\u5c11\u9032\u884c\u9019\u4e9b\u8abf\u6574\u3002\u5373\u4f7f\u814e\u529f\u80fd\u9069\u5ea6\u4e0b\u964d\u4e5f\u8207\u63a5\u53d7DOAC\u6cbb\u7642\u7684\u60a3\u8005\u51fa\u8840\u98a8\u96aa\u589e\u52a0\u76f8\u95dc\uff0c\u5f37\u8abf\u9700\u8981\u4ed4\u7d30\u76e3\u6e2c\u4e26\u9069\u7576\u8abf\u6574\u5291\u91cf\u3002 \u6297\u51dd\u8a3a\u6240\u6216\u81e8\u5e8a\u85e5\u5e2b\u7684\u5c08\u79d1\u8b77\u7406\u8207\u6539\u5584\u7684DOAC\u5291\u91cf\u8abf\u6574\u548c\u7d50\u679c\u76f8\u95dc\u3002\u5c0d\u89c0\u5bdf\u5230\u7684\u4e0d\u540c\u90e8\u4f4d\u4e4b\u9593\u8868\u73fe\u7684\u5dee\u7570\u9032\u884c\u9032\u4e00\u6b65\u7814\u7a76\u53ef\u80fd\u70ba\u9032\u4e00\u6b65\u6539\u5584\u63a5\u53d7DOAC\u6cbb\u7642\u7684\u60a3\u8005\u7684\u8b77\u7406\u54c1\u8cea\u63d0\u4f9b\u6a5f\u6703[4]\u3002 \u9032\u4e00\u6b65\u7814\u7a76\u7684\u9700\u6c42 \u5168\u7403\u60a3\u75c5\u7387\u70ba1%-2%\uff0cHF\u4ee3\u8868\u4e00\u7a2e\u4e3b\u8981\u7684\u5168\u7403\u75be\u75c5\uff0c\u9810\u8a08\u5f71\u97ff\u8d85\u904e800\u842c\u6210\u4eba\uff0c\u4e26\u4e14\u9810\u8a08\u52302030\u5e74\uff0cHF\u76f8\u95dc\u7e3d\u6210\u672c\u5c07\u589e\u52a0\u5230700\u5104\u7f8e\u5143\u3002 \u5118\u7ba1\u6700\u8fd1\u5728HF\u7684\u91ab\u5b78\u7ba1\u7406\u65b9\u9762\u53d6\u5f97\u4e86\u5faa\u8b49\u9032\u5c55\uff0c\u8af8\u5982\u4f75\u5165\u690d\u5165\u5f0f\u5fc3\u81df\u53bb\u98a4\u5668\u548c\u5fc3\u81df\u518d\u540c\u6b65\u6cbb\u7642\uff0c\u4f465\u5e74\u6642\u8207HF\u76f8\u95dc\u7684\u6b7b\u4ea1\u7387\u4ecd\u7136\u5f88\u9ad8\uff0c\u7d04\u70ba50%\u3002 \u9451\u65bcHF\u60a3\u8005\u9762\u81e8\u9ad8\u8840\u6813\u6813\u585e\u98a8\u96aa\uff0c\u5c24\u5176\u662f\u5b58\u5728AF\u7684\u60c5\u6cc1\u4e0b\uff0cDOAC\u6cbb\u7642\u4f3c\u4e4e\u662f\u4e00\u7a2e\u964d\u4f4e\u8840\u6813\u6813\u585e\u4e8b\u4ef6\u98a8\u96aa\u7684\u5408\u7406\u65b9\u6cd5\uff0c\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\u7279\u5fb5\u3002\u7136\u800c\uff0c\u7531\u65bc\u7f3a\u4e4f\u5177\u9ad4\u8cc7\u6599\uff0c\u81e8\u5e8a\u6c7a\u7b56\u76ee\u524d\u6839\u64da\u4e00\u822cAF\u7fa4\u9ad4\u4e2d\u5927\u578bRCT\u7684\u8b49\u64da\u9032\u884c\u8abf\u6574\u3002 \u5728HF\u4e2d\u4f7f\u7528DOAC\u6642\uff0c\u82e5\u5e72\u91cd\u8981\u554f\u984c\u4ecd\u672a\u89e3\u6c7a\uff0c\u4e14\u9700\u8981\u9032\u4e00\u6b65\u6df1\u5165\u5206\u6790\u3002DOAC\u662f\u5426\u5f71\u97ff\u7279\u5b9a\u7684HF\u7d42\u9ede\uff0c\u8af8\u5982HF\u60e1\u5316\u6216\u4f4f\u9662\uff1f\u6211\u5011\u61c9\u5982\u4f55\u7ba1\u7406\u60a3\u6709\u5408\u4f75\u75c7\u4e4bHF-AF\u60a3\u8005\u7684\u6297\u51dd\u8840\uff1f\u5728HF-AF-CAD\u60a3\u8005\u4e2d\uff0c\u6211\u5011\u61c9\u8a72\u5982\u4f55\u7d44\u5408\u6297\u8840\u5c0f\u677f\u53ca\u6297\u51dd\u5291\uff1f\u6211\u5011\u53ef\u4ee5\u5b89\u5168\u6709\u6548\u5730\u5728LV\u8840\u6813\u6027HFAF\u60a3\u8005\u4e2d\u4f7f\u7528DOAC\u55ce\uff1f\u5c0d\u65bcLV\u8840\u6813\u53caAF\u98a8\u96aa\u589e\u52a0\u7684HF\u60a3\u8005\uff0c\u6211\u5011\u61c9\u4f55\u6642\u958b\u59cbDOAC\u7642\u6cd5\uff1f HF\u4ee3\u8868\u4e00\u7a2e\u7368\u7279\u7684\u81e8\u5e8a\u74b0\u5883\uff0c\u9700\u8981\u9776\u5411\u81e8\u5e8a\u7814\u7a76\u53ca\u5b9a\u88fd\u7642\u6cd5\u4f86\u9650\u5236\u4e0d\u826f\u4e8b\u4ef6\u3002\u6b64\u985e\u7814\u7a76\u5c07\u6709\u52a9\u65bc\u5b9a\u7fa9\u5728\u9f90\u5927HF\u60a3\u8005\u7fa4\u9ad4\u53ca\u55ae\u4e00\u4e0d\u540c\u81e8\u5e8a\u60c5\u5883\u4e2dDOAC\u9078\u64c7\u7684\u81e8\u5e8a\u6c7a\u7b56\u3002[3] *DOAC\uff1a2023\u5e74ISTH SSC\u5efa\u8b70\u6309\u6297\u51dd\u85e5\u7269\u7684\u6295\u4e88\u65b9\u5f0f\u548c\u7279\u7570\u6027\u6a19\u9776\uff08\u4f8b\u5982\uff0c\u53e3\u670d\u56e0\u5b50Xia\u6291\u5236\u5291\u3001\u51dd\u8840\u56e0\u5b50Xia\u6291\u5236\u5291\uff09\u4f86\u63cf\u8ff0\u6297\u51dd\u85e5\u7269\u3002 (5) \u53c3\u8003\u6587\u737b\uff1a [1]\u00a0SINIARSKI\uff0cA.\u7b49\u4eba(2023) \u300cBlood coagulation disorders in heart failure\uff1aFrom basic science to clinical perspectives\u300d\uff0cJournal of Cardiac Failure\uff0c29(4)\uff0c\u7b2c517-526\u9801\u3002 doi\uff1a10.1016\/j.cardfail.2022.12.012\u3002 [2]\u00a0Kim\uff0cJ.H.\u7b49\u4eba(2016) \u300cCoagulation abnormalities in heart failure\uff1aPathophysiology and therapeutic implications\u300d\uff0cCurrent Heart Failure Reports\uff0c13(6)\uff0cpp. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":137877,"parent":0,"menu_order":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"tags":[12428,12446],"pillarandcategory":[283,292,282],"reporter":[12696,12705],"class_list":["post-141339","acf_article","type-acf_article","status-publish","has-post-thumbnail","hentry","tag-12428","tag-12446","pillarandcategory-cardiology","pillarandcategory-coagulation","pillarandcategory-disease-area","reporter-niti-dawar","reporter-yingli-huang"],"acf":[],"_links":{"self":[{"href":"https:\/\/labinsights.com\/zhtw\/wp-json\/wp\/v2\/acf_article\/141339","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labinsights.com\/zhtw\/wp-json\/wp\/v2\/acf_article"}],"about":[{"href":"https:\/\/labinsights.com\/zhtw\/wp-json\/wp\/v2\/types\/acf_article"}],"author":[{"embeddable":true,"href":"https:\/\/labinsights.com\/zhtw\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":8,"href":"https:\/\/labinsights.com\/zhtw\/wp-json\/wp\/v2\/acf_article\/141339\/revisions"}],"predecessor-version":[{"id":144785,"href":"https:\/\/labinsights.com\/zhtw\/wp-json\/wp\/v2\/acf_article\/141339\/revisions\/144785"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/labinsights.com\/zhtw\/wp-json\/wp\/v2\/media\/137877"}],"wp:attachment":[{"href":"https:\/\/labinsights.com\/zhtw\/wp-json\/wp\/v2\/media?parent=141339"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/labinsights.com\/zhtw\/wp-json\/wp\/v2\/tags?post=141339"},{"taxonomy":"pillarandcategory","embeddable":true,"href":"https:\/\/labinsights.com\/zhtw\/wp-json\/wp\/v2\/pillarandcategory?post=141339"},{"taxonomy":"reporter","embeddable":true,"href":"https:\/\/labinsights.com\/zhtw\/wp-json\/wp\/v2\/reporter?post=141339"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}