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DNA \u7684 NGS \u9996\u5148\u5c07 DNA \u7247\u6bb5\u5316\uff0c\u7136\u5f8c\u64f4\u589e\u7247\u6bb5\u4ee5\u5efa\u7acb\u8cc7\u6599\u5eab\uff0c\u800c\u9019\u4e9b\u8cc7\u6599\u5eab\u6703\u540c\u6642\u9032\u884c\u591a\u500b\u5b9a\u5e8f\u5faa\u74b0\u3002\u7522\u751f\u3001\u5206\u6790\u5927\u91cf\u539f\u59cb\u8cc7\u6599\uff0c\u4e26\u8207\u53c3\u8003\u4eba\u985e\u57fa\u56e0\u9ad4\u9032\u884c\u6bd4\u8f03\uff0c\u4ee5\u9451\u5b9a\u8b8a\u7570\u9ad4\u6216\u7a81\u8b8a\u3002\u4e0d\u540c\u65bc\u7fd2\u7528\u6851\u683c\u6c0f\u5b9a\u5e8f\uff0c\u8f03\u820a\u7684NGS\u6280\u8853\u80fd\u5920\u5feb\u901f\u8b80\u53d6\u8f03\u5927\u7684DNA\u5e8f\u5217\uff0c\u4f46\u7522\u751f\u7684\u8cc7\u6599\u96e3\u4ee5\u89e3\u91cb\u3002\u8f03\u65b0\u4e14\u8f03\u654f\u611f\u4e4bNGS\u7cfb\u7d71\u5df2\u6539\u826f\u8a72\u7b49\u554f\u984c\uff0c\u4e14\u73fe\u5728\u4ea6\u53ef\u65bc\u8986\u84cb\u5168\u57fa\u56e0\u9ad4\u6216\u8f49\u9304\u9ad4\u6642\u6aa2\u6e2c\u7f55\u898b\u907a\u50b3\u8b8a\u7570\u9ad4\u53ca\u55ae\u6838\u82f7\u9178\u591a\u578b\u6027(SNP)\u3002NGS\u5df2\u88ab\u8b49\u660e\u5728\u591a\u7a2e\u60c5\u6cc1\u4e0b\u6709\u50f9\u503c\uff0c\u8af8\u5982\u7576\u6240\u6709\u55ae\u4e00\u7a81\u8b8a\u6216\u71b1\u9ede\u6e2c\u8a66\u90fd\u672a\u80fd\u986f\u793a\u53ef\u9776\u5411\u7a81\u8b8a\u6216\u7576\u53ef\u7528\u65bc\u9806\u5e8f\u55ae\u4e00\u751f\u7269\u6a19\u7c64\u6e2c\u8a66\u7684\u816b\u7624\u6750\u6599\u4e0d\u8db3\u6642\u3002\u7531\u65bc\u8a31\u591a\u57fa\u56e0\u4fc2\u5728\u55ae\u4e00\u6e2c\u8a66\u4e2d\u9032\u884c\u8a55\u4f30\uff0c\u56e0\u6b64\u81e8\u5e8a\u91ab\u5e2b\u53ef\u4ee5\u5c0d\u53ef\u80fd\u7684\u6f5b\u5728\u6cbb\u7642\u5e72\u9810\u7372\u5f97\u66f4\u5ee3\u6cdb\u7684\u8a3a\u65b7\u898b\u89e3\uff0c\u5176\u4e2d\u4e00\u4e9b\u91dd\u5c0d\u7279\u5b9a\u60a3\u8005\u3002\u5c07\u764c\u75c7\u57fa\u56e0\u7d44\u7684 NGS \u6578\u64da\u8207\u73fe\u6709\u7642\u6cd5\u9032\u884c\u5339\u914d\uff0c\u5df2\u7d93\u70ba\u67d0\u4e9b\u764c\u75c7\u60a3\u8005\u5e36\u4f86\u4e86\u7a4d\u6975\u7684\u6cbb\u7642\u6548\u679c\u3002\u4f8b\u5982\uff0c\u5728\u80ba\u764c\u4e2d\uff0c\u5b83\u6709\u52a9\u65bc\u5404\u7a2e\u9776\u5411\u7642\u6cd5\u7684\u4f7f\u7528\u548c\u6709\u6548\u6027\uff0c\u4f8b\u5982EGFR TKI [1]\u00a0\u548cALK\u963b\u65b7\u5291[2]\u3002\u7576\u665a\u671f\u764c\u75c7\u60a3\u8005\u63a5\u53d7\u8207\u7a81\u8b8a\u5339\u914d\u7684\u6cbb\u7642\u6642\uff0c\u76f8\u8f03\u65bc\u7121\u5339\u914d\u7684\u60a3\u8005\uff0c\u4ed6\u5011\u7684\u5b58\u6d3b\u6642\u9593\u66f4\u9577\uff0c\u7e3d\u9ad4\u53cd\u61c9\u7387\u66f4\u9ad8\uff0c\u6cbb\u7642\u5931\u6557\u7684\u6642\u9593\u4e5f\u66f4\u9577[3]\u3002\u91dd\u5c0d\u7279\u5b9a\u5206\u5b50\u7570\u5e38\uff08\u5982\u62f7\u8c9d\u6578\u64f4\u589e\uff08\u5982 HER2\uff09\u6216\u86cb\u767d\u8cea\u8868\u73fe\uff08ER\/PR\/HER2 \u8868\u73fe\uff09\uff09\u7684\u5339\u914d\uff0c\u4e5f\u6539\u5584\u4e86\u60a3\u8005\u7684\u6cbb\u7642\u6548\u679c\u3002\u5118\u7ba1\u6211\u5011\u5728\u7cbe\u5bc6\u816b\u7624\u5b78\u9818\u57df\u5df2\u898b\u5feb\u901f\u9032\u5c55\uff0c\u4f46\u8a31\u591aNGS\u6e2c\u5e8f\u816b\u7624\u4ecd\u5c07\u5177\u6709\u75c5\u539f\u6027\u7a81\u8b8a\uff0c\u5176\u76ee\u524d\u7121\u6cd5\u8207\u53ef\u7528\u6cbb\u7642\u6216\u81e8\u5e8a\u8a66\u9a57\u76f8\u5339\u914d\u3002\u7136\u800c\uff0cNGS\u53ef\u4ee5\u6355\u7372\u816b\u7624\u4e2d\u66f4\u5168\u9762\u7684\u764c\u75c7\u7a81\u8b8a\u53ca\u7570\u5e38\uff0c\u9019\u4e9b\u7a81\u8b8a\u53ca\u7570\u5e38\u53ef\u80fd\u9069\u5408\u7528\u8207\u6df1\u5ea6\u53ca\u6301\u4e45\u53cd\u61c9\u76f8\u95dc\u7684\u9776\u5411\u85e5\u7269\u9032\u884c\u6cbb\u7642\uff0c\u4e26\u8fa8\u8b58\u53ef\u80fd\u53d7\u76ca\u65bc\u65b0\u578b\u6cbb\u7642\u65b9\u6cd5\u53ca\u81e8\u5e8a\u8a66\u9a57\u7684\u60a3\u8005\u3002<\/p>\n
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\u7531\u65bc\u8a31\u591aNGS\u7814\u7a76\u90fd\u6210\u529f\u986f\u793a\u51fa\u81e8\u5e8a\u7642\u6548\uff0c\u56e0\u6b64\u6c92\u6709\u986f\u8457\u57fa\u56e0\u7d44\u5b78\u5c08\u696d\u77e5\u8b58\u7684\u91ab\u5e2b\u61c9\u8a72\u53c3\u8207\u5206\u5b50\u816b\u7624\u59d4\u54e1\u6703(MTB)\u3002\u5728MTB\u4e2d\uff0c\u4f86\u81ea\u591a\u500b\u81e8\u5e8a\u53ca\u79d1\u5b78\u5b78\u79d1\u7684\u9818\u57df\u5c08\u5bb6\u7a4d\u6975\u5be9\u67e5\u53ef\u80fd\u96e3\u4ee5\u89e3\u8b80\u7684\u771f\u5be6\u4e16\u754c\u60a3\u8005NGS\u5831\u544a\u3002MTB\u901a\u5e38\u5305\u62ec\u81f3\u5c11\u4e00\u540d\u719f\u6089\u53ef\u7528\u7684\u6a19\u9776\u6cbb\u7642\u548c\u81e8\u5e8a\u8a66\u9a57\u9078\u64c7\u4ee5\u53ca\u60a3\u8005\u7279\u5b9a\u56e0\u7d20\u7684\u91ab\u5b78\u816b\u7624\u5b78\u5bb6\uff1b\u4e00\u540d\u5177\u6709\u5206\u5b50\u5206\u6790\u76f8\u95dc\u8cc7\u8a0a\u7684\u5206\u5b50\u75c5\u7406\u5b78\u5bb6\uff1b\u4ee5\u53ca\u4e00\u540d\u764c\u75c7\u907a\u50b3\u5b78\u5bb6\uff0c\u5176\u53ef\u4ee5\u5c31\u4efb\u4f55\u5df2\u9451\u5b9a\u7684\u9ad4\u7d30\u80de\u7a81\u8b8a\u7684\u7a2e\u7cfb\u5f71\u97ff\u63d0\u4f9b\u610f\u898b\u3002MTB\u4e5f\u662f\u91ab\u5e2b\u6559\u80b2\u7684\u7406\u60f3\u8ad6\u58c7\uff0c\u56e0\u70ba\u5b83\u5011\u53ef\u4ee5\u589e\u52a0\u5c0d\u57fa\u56e0\u9ad4\u8cc7\u6599\u3001\u5b9a\u5e8f\u6280\u8853\u548c\u5b9a\u5e8f\u5339\u914d\u7642\u6cd5\u7684\u7406\u89e3\u3002\u5728NCIS\uff0c\u6bcf\u9031MTB\u7531NCIS\u958b\u767c\u6cbb\u7642\u90e8(DTU)\u6301\u6709\uff0c\u4ee5\u5be9\u67e5\u5206\u5b50\u8b5c\u5206\u6790\u8cc7\u6599\u3002NCIS 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\u53c3\u8003\u6587\u737b\uff1a<\/em><\/p>\n \n[1]<\/a> Zhao J, et al. \u300c\u201cNext generation sequencing based mutation profiling reveals heterogeneity of clinical response and resistance to osimertinib.\u201dLung Cancer. 2020 Mar; vol. 141:114-118.<\/p>\n [2]<\/a> Zhy Y, et al. \u201cDurable complete response to alectinib in a lung adenocarcinoma patient with brain metastases and low-abundance EML4-ALK variant in liquid biopsy: a case report.\u201dFrontiers in Oncology. 2020 Jul; 10:1259. \u7c21\u4ecb-\u65b0\u52a0\u5761\u7684NGS & \u7cbe\u6e96\u816b\u7624\u5b78 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DNA \u7684 NGS \u9996\u5148\u5c07 DNA 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NGS & Precision Oncology in South Korea perspective\uff1aKim Jee- HyunNGS & Precision Oncology in Hong Kong perspective\uff1aDr Dr Lam Tai- ChungNGS & Precision Oncology in India perspective\uff1aAmit RauthanNGS & Precision Oncology in 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\n[3]<\/a> Tismberidou, AS, et al. \u201cPersonalized medicine in a phase I clinical trials program: the MD Anderson Cancer Center initiative.\u201dClin Cancer Res. 2012 Nov; 18(22):6373-83.
\n[4]<\/a> Tan DSP, et al. \u201cRecommendations to improve the clinical adoption of NGS-based cancer diagnostics in Singapore.\u201dAsia Pacific Journal of Clinical Oncology. 2020 Apr; Volume 16, Issue 4.<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"