{"id":144175,"date":"2021-08-06T06:05:16","date_gmt":"2021-08-06T06:05:16","guid":{"rendered":"https:\/\/labinsights.com\/acf_article\/csf-%e7%94%9f%e7%89%a9%e6%a8%99%e8%aa%8c%e7%89%a9%e5%8f%8a%e5%85%b6%e5%9c%a8%e9%98%bf%e6%bb%8b%e6%b5%b7%e9%bb%98%e7%97%87%e7%ae%a1%e7%90%86%e4%b8%ad%e7%9a%84%e4%bd%9c%e7%94%a8\/"},"modified":"2026-01-19T04:54:33","modified_gmt":"2026-01-19T04:54:33","slug":"csf-biomarkers-and-their-role-in-alzheimers-disease-management","status":"publish","type":"acf_article","link":"https:\/\/labinsights.com\/zhtw\/operations\/immunoassay\/csf-biomarkers-and-their-role-in-alzheimers-disease-management\/","title":{"rendered":"CSF \u751f\u7269\u6a19\u8a8c\u7269\u53ca\u5176\u5728\u963f\u6ecb\u6d77\u9ed8\u75c7\u7ba1\u7406\u4e2d\u7684\u4f5c\u7528"},"content":{"rendered":"

\u5728\u5168\u7403\u4eba\u53e3\u6301\u7e8c\u8001\u5316\u7684\u60c5\u6cc1\u4e0b\uff0c\u963f\u6ecb\u6d77\u9ed8\u75c7\u662f\u4e00\u500b\u56b4\u91cd\u4e14\u8fc5\u901f\u6210\u9577\u7684\u516c\u5171\u885b\u751f\u554f\u984c\u3002\u4f30\u8a08\u50c5\u4e9e\u592a\u5730\u5340\u4eca\u5929\u5c31\u6709\u8d85\u904e 2300 \u842c\u4f8b\u75c5\u4f8b\uff0c\u9810\u8a08\u5230 2050 \u5e74\u5c07\u8d85\u904e 7000 \u842c\u4f8b [1]\u3002\u96d6\u7136\u76ee\u524d\u5f88\u591a\u6ce8\u610f\u529b\u90fd\u96c6\u4e2d\u5728 FDA \u6700\u8fd1\u6279\u51c6\u7684\u65b0\u00a0\u6cbb\u7642\u5e72\u9810\u00a0\u4e0a\uff0c\u4f46\u81e8\u5e8a\u5be6\u9a57\u5ba4\u8a3a\u65b7\u5c0d\u65bc\u5e6b\u52a9\u7ba1\u7406\u9019\u4e00\u65e5\u76ca\u56b4\u91cd\u7684\u5371\u6a5f\u4e5f\u6975\u70ba\u91cd\u8981\u3002<\/p>\n

\u4ec0\u9ebc\u662f CSF \u751f\u7269\u6a19\u8a8c\u7269\uff1f<\/h3>\n

\u591a\u9805\u7814\u7a76\u5df2\u7d93\u986f\u793a 3 \u7a2e\u6838\u5fc3\u8166\u810a\u6db2 (CSF) \u751f\u7269\u6a19\u8a8c\u7269 \u2014 \u03b2- \u985e\u6fb1\u7c89\u86cb\u767d 42 (\u03b1\u03b242)\u3001\u7e3d tau (T-tau) \u548c\u78f7\u9178\u5316 tau (P-tau) \u2014 \u5728\u963f\u6ecb\u6d77\u9ed8\u75c7\u8a3a\u65b7\u904e\u7a0b\u4e2d\u7684\u50f9\u503c\u3002\u5728 CSF \u4e2d\u4ee5\u8f03\u4f4e\u6fc3\u5ea6\u5075\u6e2c\u5230 \u03b1\u03b242 \u6c34\u6e96\uff0c\u4e26\u4e14\u9019\u7a2e\u8b8a\u5316\u5728\u963f\u6ecb\u6d77\u9ed8\u75c7\u751a\u81f3\u88ab\u6b63\u5f0f\u8a3a\u65b7\u4e4b\u524d\u81f3\u5c11 5 \u5e74\u5c31\u53ef\u4ee5\u770b\u5230 [2]\u3002T-tau \u53ca P-tau\uff08\u5169\u8005\u7686\u70ba\u795e\u7d93\u5143\u55aa\u5931\u7684\u6a19\u8a8c\u7269\uff09\u59cb\u7d42\u5728\u9ad8\u65bc\u57fa\u7dda\u7684\u6c34\u6e96\u589e\u52a0\u6642\u88ab\u767c\u73fe [3]\u3002<\/p>\n

CSF \u53ef\u900f\u904e\u8170\u690e\u7a7f\u523a\u7372\u5f97\uff0c\u5176\u5167\u5bb9\u7269\u88ab\u8996\u70ba\u5927\u8166\u74b0\u5883\u7684\u76f4\u63a5\u53cd\u6620\u3002\u5373\u4f7f\u5982\u6b64\uff0cCSF \u751f\u7269\u6a19\u8a8c\u7269\u76ee\u524d\u5c1a\u672a\u5ee3\u6cdb\u7528\u65bc\u81e8\u5e8a\u8a3a\u65b7\u3002\u8fc4\u4eca\u70ba\u6b62\uff0c\u5c1a\u672a\u5c31\u4efb\u4f55\u78ba\u5b9a\u7684\u622a\u6b62\u6c34\u6e96\u9054\u6210\u6b63\u5f0f\u5171\u8b58\uff0c\u4f46\u6b63\u5728\u52aa\u529b\u5c07\u9019\u4e9b\u50f9\u503c\u89c0\u6a19\u6e96\u5316\u3002<\/p>\n

\u9451\u65bc\u591a\u9805\u81e8\u5e8a\u6307\u5357\u7684\u8b8a\u5316\uff0c\u4f8b\u5982\u7f8e\u570b\u570b\u5bb6\u9ad8\u9f61\u5316\u7814\u7a76\u6240\u548c\u963f\u6ecb\u6d77\u9ed8\u75c7\u5354\u6703\u00a0(NIA-AA)\u00a0\u7684\u8a55\u4f30\uff0c\u5373\u963f\u6ecb\u6d77\u9ed8\u75c7\u8a3a\u65b7\u73fe\u5728\u53ef\u4ee5\u57fa\u65bc\u751f\u7269\u5b78\uff0c\u7121\u8ad6\u75c7\u72c0\u7684\u5b58\u5728\u548c\u56b4\u91cd\u7a0b\u5ea6\u5982\u4f55 [4]\uff0c\u4ee5\u53ca\u963f\u6ecb\u6d77\u9ed8\u75c7\u5354\u6703\u7684\u5916\u90e8\u54c1\u8cea\u63a7\u5236\u8a08\u756b\u00a0[5]\uff0c\u73fe\u5728\u53ef\u80fd\u53ef\u4ee5\u5728\u81e8\u5e8a\u74b0\u5883\u4e2d\u66f4\u591a\u5730\u4f7f\u7528 CSF \u751f\u7269\u6a19\u8a8c\u7269\u3002\u5982\u679c\u7372\u5f97\u6279\u51c6\uff0cCSF\u751f\u7269\u6a19\u8a8c\u7269\u7684\u4f7f\u7528\u4e5f\u53ef\u4ee5\u96a8\u8457\u81ea\u52d5\u5316\u7684\u589e\u52a0\u800c\u589e\u52a0\uff0c\u85c9\u6b64\u6e1b\u5c11\u4eba\u70ba\u64cd\u4f5c\u548c\u932f\u8aa4\u3002<\/p>\n

\u9069\u6642\u8a3a\u65b7\u7684\u597d\u8655<\/h3>\n

\u963f\u6ecb\u6d77\u9ed8\u75c7\u5e7e\u4e4e\u7e3d\u662f\u59cb\u65bc\u8f15\u5fae\u7684\u88ab\u5ffd\u8996\u75c7\u72c0\uff0c\u4f8b\u5982\u4e00\u4e9b\u5bb9\u6613\u6b78\u56e0\u65bc\u5e74\u9f61\u7684\u5065\u5fd8\u6642\u523b\u3002\u6b64\u6642\uff0c\u60a3\u8005\u6700\u6709\u53ef\u80fd\u7d93\u6b77\u4e3b\u89c0\u8a8d\u77e5\u8870\u9000\uff1b\u8a8d\u77e5\u529f\u80fd\u53ef\u80fd\u53d7\u640d\uff0c\u4f46\u7121\u6cd5\u50c5\u85c9\u7531\u81e8\u5e8a\u8a55\u5b9a\u4f86\u78ba\u8a8d\u3002<\/p>\n

\u6b64\u9023\u7e8c\u904e\u7a0b\u4e2d\u7684\u4e0b\u4e00\u968e\u6bb5\u70ba\u8f15\u5ea6\u8a8d\u77e5\u969c\u7919 (MCI)\uff0c\u7531\u6b64\u53ef\u85c9\u7531\u795e\u7d93\u5f71\u50cf\u5b78\u767c\u73fe\u81e8\u5e8a\u8b49\u64da\u3002\u7531\u65bc MCI \u4ea6\u898b\u65bc\u5176\u4ed6\u795e\u7d93\u9000\u5316\u6027\u75be\u60a3\uff0c\u56e0\u6b64 CSF \u751f\u7269\u6a19\u8a8c\u7269\u6709\u52a9\u65bc\u9451\u5225\u8a3a\u65b7\u3002\u9451\u65bc\u751f\u7406\u8b8a\u5316\u8207\u81e8\u5e8a\u75c7\u72c0\u4e4b\u9593\u7684\u6642\u9593\u6eef\u5f8c\uff0c\u4e26\u4e14\u9451\u65bc MCI \u70ba\u963f\u6ecb\u6d77\u9ed8\u75c7\u7684\u98a8\u96aa\u56e0\u7d20\uff0c\u4f7f\u7528 CSF \u751f\u7269\u6a19\u8a8c\u7269\u9032\u884c\u9069\u6642\u8a3a\u65b7\u53ef\u80fd\u5f71\u97ff\u60a3\u8005\u5c0d\u963f\u6ecb\u6d77\u9ed8\u75c7\u7684\u9ad4\u9a57\u3002<\/p>\n

\u5728 CSF \u751f\u7269\u6a19\u8a8c\u7269\u4e4b\u524d\uff0c\u963f\u6ecb\u6d77\u9ed8\u75c7\u4e4b\u8a3a\u65b7\u4f9d\u8cf4\u65bc\u795e\u7d93\u5f71\u50cf\u5b78\uff08\u8af8\u5982\u985e\u6fb1\u7c89\u86cb\u767d PET \u6383\u63cf\uff09\u4f86\u5075\u6e2c\u8166\u4e2d\u4e4b\u985e\u6fb1\u7c89\u86cb\u767d\u6591\u584a\uff0c\u5176\u70ba\u963f\u6ecb\u6d77\u9ed8\u75c7\u4e4b\u7279\u5fb5\u3002\u4e0d\u904e\uff0c\u9019\u7a2e\u65b9\u6cd5\u6709\u5176\u4fb7\u9650\u6027\uff0c\u5f9e\u665a\u671f\u8a3a\u65b7\u5230\u88dd\u7f6e\u548c\u5c08\u696d\u4eba\u54e1\u7121\u6cd5\u63a5\u8fd1\u3002\u9019\u53ef\u4ee5\u89e3\u91cb\u70ba\u4ec0\u9ebc 50-70% \u7684\u60a3\u8005\u751a\u81f3\u6c92\u6709\u63a5\u53d7\u6b63\u5f0f\u8a3a\u65b7\u3002<\/p>\n

\u9069\u6642\u7684\u8a3a\u65b7\u53ef\u4ee5\u660e\u78ba\u6aa2\u6e2c\u963f\u6ecb\u6d77\u9ed8\u75c7 [6]\uff0c\u4e26\u61c9\u7528\u5e72\u9810\u7642\u6cd5\u6216\u5165\u7d44\u81e8\u5e8a\u8a66\u9a57 [7]\u3002\u5728\u8a3a\u6240\u4e4b\u5916\uff0c\u75c5\u60a3\u5145\u5206\u77ad\u89e3\u60c5\u6cc1\uff0c\u4e26\u80fd\u5920\u6c7a\u5b9a\u81ea\u5df1\u7684\u672a\u4f86\uff0c\u5f9e\u6c7a\u5b9a\u672a\u4f86\u7684\u751f\u6d3b\u9078\u64c7\u5230\u505a\u51fa\u9069\u7576\u7684\u6cd5\u5f8b\u5b89\u6392\u3002\u9069\u6642\u7684\u8a3a\u65b7\u4e5f\u53ef\u4ee5\u70ba\u67d0\u500b\u570b\u5bb6\u7684\u91ab\u7642\u4fdd\u5065\u7cfb\u7d71\u5982\u4f55\u5851\u9020\u672a\u4f86\u6578\u5341\u5e74\u7684\u653f\u7b56\u63d0\u4f9b\u8cc7\u8a0a\u3002<\/p>\n

\u53ef\u80fd\u505a\u70ba\u4f34\u96a8\u5f0f\u8a3a\u65b7\u4f7f\u7528<\/h3>\n

CSF \u751f\u7269\u6a19\u8a8c\u7269\u5df2\u7528\u65bc\u65e8\u5728\u5e72\u9810\u963f\u6ecb\u6d77\u9ed8\u75c7\u81e8\u5e8a\u9032\u5c55\u4e4b\u75be\u75c5\u7de9\u89e3\u7642\u6cd5 (DMT) \u7684\u81e8\u5e8a\u8a66\u9a57 [8]\u3002\u70ba\u4e86\u5c0d\u7b26\u5408\u81e8\u5e8a\u8a66\u9a57\u689d\u4ef6\u7684\u60a3\u8005\u9032\u884c\u9069\u7576\u5206\u5c64\uff0c\u9032\u884c CSF \u751f\u7269\u6a19\u8a8c\u7269\uff08\u548c PET \u6383\u63cf\uff09\u505a\u70ba\u78ba\u8a8d\u6e2c\u8a66\uff0c\u4ee5\u986f\u793a\u751f\u7406\u8b8a\u5316\u7684\u5b58\u5728\u3002<\/p>\n

\u96a8\u8457\u751f\u7269\u6a19\u8a8c\u7269\u6aa2\u5b9a\u6578\u91cf\u7684\u589e\u52a0\u548c\u6a19\u6e96\u5316\u7684\u9032\u5c55\uff0cCSF \u751f\u7269\u6a19\u8a8c\u7269\u53ef\u5ee3\u6cdb\u652f\u63f4\u81e8\u5e8a\u8a66\u9a57\u4e2d\u7684\u95dc\u9375\u91cc\u7a0b\u7891\u3002\u4e00\u500b\u7f3a\u9ede\u53ef\u80fd\u662f\u60a3\u8005\u5c0d\u591a\u6b21\u8170\u690e\u7a7f\u523a\u7684\u8010\u53d7\u6027\u53ef\u80fd\u4e0d\u4f73\uff0c\u9019\u63a8\u52d5\u4e86\u9032\u4e00\u6b65\u7814\u7a76\u958b\u767c\u57fa\u65bc\u8840\u6db2\u7684\u751f\u7269\u6a19\u8a8c\u7269\u505a\u70ba\u66ff\u4ee3\u65b9\u6848\u7684\u9700\u6c42\u3002<\/p>\n

\u8a31\u591a\u7814\u7a76\u5df2\u7d93\u63d0\u51fa\u4e86\u9069\u6642\u8a3a\u65b7\u7684\u6f5b\u5728\u76ca\u8655\uff0c\u5305\u62ec\u7528 DMT \u9032\u884c\u65e9\u671f\u6cbb\u7642\u6216\u65e9\u671f\u5e72\u9810\u7684\u6a5f\u6703\u3002\u96a8\u8457\u85e5\u7406\u88fd\u5291\u4e0a\u5e02\uff0c\u9019\u7a2e\u7406\u8ad6\u4e0a\u7684\u6548\u76ca\u73fe\u5728\u6709\u6a5f\u6703\u6210\u70ba\u73fe\u5be6\u3002\u65b0\u85e5\u7684\u51fa\u73fe\u53ef\u80fd\u6703\u70ba\u66f4\u591a\u5065\u5eb7\u7167\u8b77\u5f9e\u696d\u8005\u63d0\u4f9b\u52d5\u529b\uff0c\u63a5\u53d7\u5c07\u751f\u7269\u6a19\u8a8c\u7269\u7528\u65bc\u5176\u60a3\u8005\u7684\u660e\u78ba\u963f\u6ecb\u6d77\u9ed8\u75c7\u8a3a\u65b7\u3002<\/p>\n

\u53c3\u8003\u6587\u737b<\/em>\uff1a<\/p>\n

[1]<\/a> Disease International \u7684 2014 \u5e74\u4e9e\u592a\u5730\u5340\u5931\u667a\u75c7\u5831\u544a<\/p>\n

[2]<\/a>\u00a0Buchhave, P.\u7b49\u4eba (2012)\u00a0Cerebrospinal Fluid Levels of \u03b2-Amyloid 1-42, but Not of Tau, Are Fully Changed Already 5 to 10 Years Before the Onset of Alzheimer Dementia\u3002\u00a0Archives of General Psychiatry<\/i>\uff0c69(1)\uff0c\u7b2c 98 \u9801\u3002<\/p>\n

[3]<\/a>\u00a0Olsson, B. \u7b49\u4eba (2016) CSF and blood biomarkers for the diagnosis of Alzheimer\u2019s disease: a systematic review and meta-analysis\u3002The Lancet Neurology<\/em>\uff0c15\uff0c\u7b2c 673-684 \u9801\u3002<\/p>\n

[4]<\/a>\u00a0Alzheimer’s Disease Diagnostic Guidelines, Dementia Resources for Health Professionals, National Institute of Health<\/p>\n

[5]<\/a>\u00a0CSF \u548c\u8840\u6db2\u751f\u7269\u6a19\u8a8c\u7269\u7684\u963f\u6ecb\u6d77\u9ed8\u75c7\u5354\u6703 QC \u8a08\u756b<\/p>\n

[6]<\/a> Dubois, B.\u7b49\u4eba (2016) Timely diagnosis for Alzheimer’s Disease: A Literature Review on Benefits and Challenges\u3002Journal of Alzheimer’s Disease<\/em>\uff0c49\uff0c\u7b2c 617-631 \u9801\u3002<\/p>\n

[7]<\/a>\u00a0Lleo, A.\u7b49\u4eba (2014) Cerebrospinal fluid biomarkers in trials for Alzheimer and Parkinson diseases\u3002Nature Reviews Neurology<\/em>\uff0c11\uff0c\u7b2c 41-55 \u9801\u3002<\/p>\n

[8]<\/a>\u00a0Horgan, D.\u7b49\u4eba (2020) Biomarker Testing: Piercing the Fog of Alzheimer’s and Related Dementia\u3002\u751f\u7269\u91ab\u5b78\u4e2d\u5fc3<\/p>\n","protected":false},"excerpt":{"rendered":"

\u5728\u5168\u7403\u4eba\u53e3\u6301\u7e8c\u8001\u5316\u7684\u60c5\u6cc1\u4e0b\uff0c\u963f\u6ecb\u6d77\u9ed8\u75c7\u662f\u4e00\u500b\u56b4\u91cd\u4e14\u8fc5\u901f\u6210\u9577\u7684\u516c\u5171\u885b\u751f\u554f\u984c\u3002\u4f30\u8a08\u50c5\u4e9e\u592a\u5730\u5340\u4eca\u5929\u5c31\u6709\u8d85\u904e 2300 \u842c\u4f8b\u75c5\u4f8b\uff0c\u9810\u8a08\u5230 2050 \u5e74\u5c07\u8d85\u904e 7000 \u842c\u4f8b [1]\u3002\u96d6\u7136\u76ee\u524d\u5f88\u591a\u6ce8\u610f\u529b\u90fd\u96c6\u4e2d\u5728 FDA \u6700\u8fd1\u6279\u51c6\u7684\u65b0\u00a0\u6cbb\u7642\u5e72\u9810\u00a0\u4e0a\uff0c\u4f46\u81e8\u5e8a\u5be6\u9a57\u5ba4\u8a3a\u65b7\u5c0d\u65bc\u5e6b\u52a9\u7ba1\u7406\u9019\u4e00\u65e5\u76ca\u56b4\u91cd\u7684\u5371\u6a5f\u4e5f\u6975\u70ba\u91cd\u8981\u3002 \u4ec0\u9ebc\u662f CSF \u751f\u7269\u6a19\u8a8c\u7269\uff1f \u591a\u9805\u7814\u7a76\u5df2\u7d93\u986f\u793a 3 \u7a2e\u6838\u5fc3\u8166\u810a\u6db2 (CSF) \u751f\u7269\u6a19\u8a8c\u7269 \u2014 \u03b2- \u985e\u6fb1\u7c89\u86cb\u767d 42 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