{"id":144208,"date":"2021-08-04T03:57:33","date_gmt":"2021-08-04T03:57:33","guid":{"rendered":"https:\/\/labinsights.com\/acf_article\/%e5%87%9d%e8%a1%80%e8%a8%ba%e6%96%b7%e5%a6%82%e4%bd%95%e6%94%af%e6%8f%b4-covid-19-%e7%96%ab%e8%8b%97%e6%8e%a5%e7%a8%ae%e5%92%8c%e6%82%a3%e8%80%85%e7%ae%a1%e7%90%86\/"},"modified":"2026-02-03T05:36:11","modified_gmt":"2026-02-03T05:36:11","slug":"how-coagulation-diagnostics-support-covid-19-vaccination-and-patient-management","status":"publish","type":"acf_article","link":"https:\/\/labinsights.com\/zhtw\/disease-area\/coagulation\/how-coagulation-diagnostics-support-covid-19-vaccination-and-patient-management\/","title":{"rendered":"\u51dd\u8840\u8a3a\u65b7\u5982\u4f55\u652f\u63f4 COVID-19 \u75ab\u82d7\u63a5\u7a2e\u548c\u60a3\u8005\u7ba1\u7406"},"content":{"rendered":"

COVID-19 \u611f\u67d3\u8207\u8840\u6813\u5f62\u6210\u6216\u8840\u51dd\u584a\u6709\u95dc\uff0c\u6d89\u53ca\u975c\u8108\u548c\u52d5\u8108\u3002\u5c0d\u65bc\u56e0 COVID-19 \u611f\u67d3\u800c\u5165\u9662\u7684\u60a3\u8005\uff0c\u8840\u51dd\u584a\u7684\u98a8\u96aa\u6700\u9ad8\uff0c\u767c\u751f\u5728\u7d04 5% \u7684\u5165\u4f4f\u666e\u901a\u91ab\u9662\u75c5\u623f\u7684\u60a3\u8005\u4e2d\uff0c\u4e14\u52a0\u8b77\u75c5\u623f (ICU) \u63a5\u53d7\u751f\u547d\u7dad\u6301\u6cbb\u7642\u7684\u60a3\u8005\u4e2d\u9ad8\u9054 20%\u3002\u4e0d\u9700\u8981\u5165\u9662\u7684 COVID-19 \u611f\u67d3\u8005\u767c\u751f\u8840\u6813\u7684\u98a8\u96aa\u8f03\u4f4e\u7d04 1% [1]\u3002<\/p>\n

\u96d6\u7136\u975e\u5e38\u4e0d\u5e38\u898b\uff0c\u4f46\u4f7f\u7528\u57fa\u65bc\u817a\u75c5\u6bd2\u4e4b\u75ab\u82d7\u9032\u884c\u75ab\u82d7\u63a5\u7a2e\u4ea6\u8207\u85c9\u7531\u7a31\u70ba\u75ab\u82d7\u8a98\u5c0e\u4e4b\u8840\u6813\u6027\u8840\u5c0f\u677f\u6e1b\u5c11\u75c7 (VITT) \u4e4b\u75c5\u75c7\u5f15\u8d77\u7684\u8840\u51dd\u584a\u76f8\u95dc\u806f\u3002\u70ba\u4e86\u66f4\u78ba\u5be6\u77ad\u89e3\u95dc\u65bc COVID-19 \u75ab\u82d7\u63a5\u7a2e\u548c\u60a3\u8005\u7ba1\u7406\u7684\u4e3b\u8981\u51dd\u8840\u98a8\u96aa\u548c\u6ce8\u610f\u4e8b\u9805\uff0cRoche Diagnostics Asia Pacific \u6700\u8fd1\u8207\u65b0\u52a0\u5761\u7e3d\u91ab\u9662\u8cc7\u6df1\u9867\u554f\u517c\u8840\u6db2\u5b78\u79d1\u4e3b\u4efb Ng Heng Joo \u91ab\u5e2b\u9032\u884c\u4ea4\u8ac7\u3002<\/p>\n

COVID-19 \u7167\u8b77\u53ca\u75ab\u82d7\u63a5\u7a2e\u5f8c\u8a55\u4f30\u4e2d\u7684\u51dd\u8840\u6a19\u7c64<\/h3>\n

\u7d2f\u7a4d\u7684\u5be6\u9a57\u5ba4\u8b49\u64da\u8868\u660e\uff0cCOVID-19 \u611f\u67d3\u60a3\u8005\u7684\u7570\u5e38\u51dd\u8840\u8b8a\u5316\u53ef\u80fd\u662f\u56b4\u91cd\u767c\u708e\u53cd\u61c9\u7684\u7d50\u679c\uff0c\u800c\u8207\u5167\u5728\u4fc3\u51dd\u4f5c\u7528\u672c\u8eab\u7121\u95dc\u3002\u91cd\u5ea6 COVID-19 \u611f\u67d3\u60a3\u8005\u53ef\u80fd\u767c\u751f\u51dd\u8840\u86cb\u767d\u986f\u8457\u589e\u52a0\uff0c\u8207\u56b4\u91cd\u7684\u6025\u6027\u671f\u53cd\u61c9\u4e00\u81f4\u3002\u4e00\u90e8\u5206\u91cd\u75c7\u80ba\u708e\u60a3\u8005\u767c\u5c55\u51fa\u75c5\u6bd2\u6027\u6557\u8840\u75c7\u3001\u64ad\u6563\u6027\u8840\u7ba1\u5167\u51dd\u8840 (DIC) \u53ca\u591a\u5668\u5b98\u8870\u7aed\u3002<\/p>\n

\u7531\u65bc D-\u96d9\u805a\u9ad4\u662f\u8840\u6813\u5f62\u6210\u60a3\u8005\u7684\u967d\u6027\u6a19\u7c64\u7269\uff0c\u56e0\u6b64\u5df2\u7d93\u9032\u884c\u591a\u9805\u7814\u7a76\uff0c\u8a66\u5716\u5c07 D-\u96d9\u805a\u9ad4\u7d0d\u5165\u5c0d COVID-19 \u56b4\u91cd\u7a0b\u5ea6\u7684\u9810\u6e2c\u4e2d\u3002 Ng \u535a\u58eb\u6307\u51fa\uff1a\u300cD – \u96d9\u805a\u9ad4\u5df2\u88ab\u7d0d\u5165 COVID-19 \u60a3\u8005\u4e2d\u975c\u8108\u8840\u6813\u6813\u585e\u767c\u5c55\u7684\u4e00\u4e9b\u98a8\u96aa\u8a55\u4f30\u5206\u6578\u4e2d\u3002\u4e00\u76f4\u4ee5\u4f86\u90fd\u5f88\u96e3\u5b9a\u7fa9\u81e8\u754c\u503c\uff0c\u56e0\u70ba\u81e8\u754c\u503c\u6703\u4ee4\u4eba\u64d4\u6182\u75be\u75c5\u56b4\u91cd\u7a0b\u5ea6\u7684\u589e\u52a0\uff0c\u4ee5\u53ca\u9019\u5c07\u5982\u4f55\u5f71\u97ff\u60a3\u8005\u7642\u6cd5\u7684\u5347\u7d1a\u3002\u300d<\/p>\n

\u4ed6\u88dc\u5145\u8aaa\uff1a\u300c\u4f7f\u7528\u7684\u4e00\u4e9b\u98a8\u96aa\u8a55\u4f30\u6a21\u578b\u7684\u5e38\u898b\u7bc4\u4f8b\u5305\u62ec\u6539\u5584\u7684 D-\u96d9\u805a\u9ad4\u8a55\u5206\u4ee5\u53ca Caprini \u8a55\u5206\u3002\u300d\u300c\u5df2\u6709\u4e00\u4e9b\u9a57\u8b49\u7814\u7a76\u8868\u660e\uff0c\u5b83\u6709\u52a9\u65bc\u9810\u6e2c\u54ea\u4e9b\u60a3\u8005\u53ef\u6b78\u985e\u70ba\u767c\u751f\u975c\u8108\u8840\u6813\u6813\u585e\u7684\u4f4e\u98a8\u96aa\u3001\u4e2d\u98a8\u96aa\u6216\u9ad8\u98a8\u96aa\u60a3\u8005\uff0c\u4e26\u56e0\u6b64\u70ba\u60a3\u8005\u6070\u7576\u4f7f\u7528\u6297\u51dd\u6cbb\u7642\u3002\u300d<\/p>\n

\u5c0d\u65bc VITT \u60a3\u8005\uff0c\u6e2c\u8a66\u901a\u5e38\u63ed\u793a\u4f4e\u7e96\u7dad\u86cb\u767d\u539f\u53ca\u975e\u5e38\u9ad8\u7684 D-\u96d9\u805a\u9ad4\u6fc3\u5ea6\uff0c\u9ad8\u65bc\u975c\u8108\u8840\u6813\u6813\u585e\u4e2d\u901a\u5e38\u9810\u671f\u7684\u6fc3\u5ea6\u3002Ng \u535a\u58eb\u5f37\u8abf\uff1a\u300c\u6211\u5011\u77e5\u9053 VITT \u7684\u6f5b\u5728\u767c\u75c5\u901a\u5e38\u5728\u75ab\u82d7\u63a5\u7a2e\u5f8c 5 \u81f3 28 \u5929\u4e4b\u9593\u3002\u6211\u5011\u77e5\u9053\u5b83\u6703\u5f15\u8d77\u4e0d\u5c0b\u5e38\u7684\u8840\u6813\u5f62\u6210\u90e8\u4f4d\uff0c\u4f8b\u5982\u8166\u975c\u8108\u7ac7\u8840\u6813\u5f62\u6210\u4ee5\u53ca\u813e\u975c\u8108\u8840\u6813\u5f62\u6210\u3002\u300d<\/p>\n

\u5df2\u5728 VITT \u60a3\u8005\u4e2d\u9451\u5b9a\u51fa\u91dd\u5c0d\u8840\u5c0f\u677f\u56e0\u5b50 4 (PF4) \u7684\u6297\u9ad4\uff0c\u56e0\u6b64\u8207\u809d\u7d20\u8a98\u5c0e\u7684\u8840\u5c0f\u677f\u6e1b\u5c11\u75c7 (HIT) \u985e\u4f3c\uff0c\u5373\u4f7f\u5148\u524d\u672a\u63a5\u53d7\u904e\u809d\u7d20\u6cbb\u7642\u4e5f\u662f\u5982\u6b64\u3002\u6297 PF4 \u6297\u9ad4\u53ef\u85c9\u7531 ELISA HIT \u6e2c\u5b9a\u6cd5\u9032\u884c\u5075\u6e2c\uff0c\u4f46\u901a\u5e38\u4e0d\u80fd\u85c9\u7531\u5feb\u901f\u8a66\u9a57\u9032\u884c\u5075\u6e2c\uff0c\u8a72\u5feb\u901f\u8a66\u9a57\u901a\u5e38\u57fa\u65bc\u5316\u5b78\u767c\u5149\u4ee5\u53ca\u4e73\u81a0\u6e2c\u5b9a\u6cd5\u3002<\/p>\n

COVID-19 \u6642\u4ee3\u51dd\u8840\u5be6\u9a57\u5ba4\u9762\u81e8\u7684\u6311\u6230<\/h3>\n

COVID-19 \u8207\u8840\u6813\u5f62\u6210\u6709\u95dc\uff0c\u9019\u7121\u7591\u7d66\u60a3\u8005\u8a3a\u65b7\u53ca\u7ba1\u7406\u5e36\u4f86\u4e86\u8a31\u591a\u6311\u6230\u3002\u5728\u5927\u6d41\u884c\u7684\u65e9\u671f\u968e\u6bb5\uff0c\u5176\u4e2d\u4e00\u500b\u6311\u6230\u662f\u77ad\u89e3 COVID-19 \u60a3\u8005\u7684\u75c5\u7406\u751f\u7406\u5b78\u6216\u8840\u6813\u5f62\u6210\u7684\u4f5c\u7528<\/a>\u3002 \u56e0\u6b64\uff0c\u5617\u8a66\u5c0d\u9ad8\u98a8\u96aa\u4eba\u7fa4\u9032\u884c\u5206\u5c64\u4ee5\u53ca\u6297\u51dd\u6cbb\u7642\u5c0d\u8a72\u7d44\u60a3\u8005\u7684\u4f5c\u7528\u5177\u6709\u6311\u6230\u6027\u3002<\/p>\n

\u53e6\u4e00\u500b\u8a3a\u65b7\u6311\u6230\u662f VITT \u7684\u5be6\u9ad4\u3002\u96d6\u7136\u91dd\u5c0d HIT \u7684\u6297 PF4 \u6297\u9ad4\u7684\u6e2c\u8a66\u5df2\u7d93\u5f97\u5230\u5145\u5206\u8b49\u5be6\uff0c\u4f46\u5176\u7528\u9014\u53ca\u5176\u5c0d\u60a3\u6709 VITT \u7684\u60a3\u8005\u672c\u8eab\u7684\u654f\u611f\u6027\u6709\u6240\u4e0d\u540c\u3002\u505a\u70ba\u50c5\u8b49\u660e\u6297 PF4 \u6297\u9ad4\u7684\u9032\u4e00\u6b65\u4f50\u5291\uff0c\u5df2\u7d93\u958b\u767c\u51fa\u984d\u5916\u7684\u6e2c\u8a66\u4f86\u78ba\u8a8d\u5b58\u5728\u6d3b\u5316\u8840\u5c0f\u677f\u4e4b\u6297\u9ad4 [2]\u3002<\/p>\n

\u9019\u4e00\u6311\u6230\u5c0e\u81f4\u958b\u767c\u5229\u7528\u73fe\u6709\u6280\u8853\u7684\u984d\u5916\u6aa2\u6e2c\uff0c\u4f8b\u5982\uff0c\u809d\u7d20\u8a98\u5c0e\u7684\u8840\u5c0f\u677f\u805a\u96c6\u6e2c\u5b9a (HIPAA)\u3002\u505a\u70ba HIPAA \u6e2c\u8a66\u7684\u4fee\u6539\uff0c\u7814\u7a76\u4eba\u54e1\u958b\u767c\u4e86\u4e00\u7a2e\u8840\u5c0f\u677f\u56e0\u5b50 4 \u8a98\u5c0e\u7684\u8840\u5c0f\u677f\u805a\u96c6\u6e2c\u8a66\uff0c\u4ee5\u8a66\u5716\u78ba\u5be6\u5730\u5b9a\u7fa9\u75c5\u56e0\u6216\u66f4\u78ba\u5207\u5730\u8aaa\u662f\u8a3a\u65b7 VITT \u60a3\u8005\u3002\u8840\u5c0f\u677f\u6d3b\u5316\u6216\u85c9\u7531\u4f7f\u7528\u6d41\u5f0f\u7d30\u80de\u5206\u6790\u6280\u8853\u7684\u6297\u9ad4\u5df2\u7528\u4f5c\u5be6\u9a57\u5ba4\u4e2d\u7684\u6e2c\u8a66\u3002\u9019\u4e9b\u6e2c\u8a66\u975e\u5e38\u6709\u7528\uff0c\u4e26\u4e14\u958b\u767c\u8d77\u4f86\u4e5f\u5f88\u6709\u6311\u6230\u6027\uff0c\u4f46\u5b83\u5011\u5df2\u5728\u8a3a\u65b7 VITT \u4e2d\u5f97\u5230\u8b49\u5be6\u3002<\/p>\n

\u65b0\u4e00\u4ee3\u51dd\u8840\u8a3a\u65b7<\/h3>\n

COVID-19 \u8a98\u5c0e\u7684\u51dd\u8840\u75c5\u8b8a\u70ba\u8868\u73fe\u51fa D-\u96d9\u805a\u9ad4\u986f\u8457\u5347\u9ad8\u7684\u7368\u7279\u5be6\u9ad4\u3002COVID-19 \u8207\u5fae\u8840\u7ba1<\/a>\u53ca\u5927\u8840\u7ba1\u8840\u6813\u5f62\u6210\u7684\u9ad8\u98a8\u96aa\u4ee5\u53ca\u6297\u51dd\u5931\u6557\u767c\u751f\u7387\u5347\u9ad8\u76f8\u95dc\u3002\u8207\u7fd2\u7528\u6557\u8840\u75c7\u4e0d\u540c\uff0c\u6297\u51dd\u5728 COVID-19 \u7ba1\u7406\u4e2d\u8d77\u8457\u95dc\u9375\u4f5c\u7528\uff0c\u5c0d\u5b58\u6d3b\u5177\u6709\u7a4d\u6975\u5f71\u97ff\u3002\u751f\u7269\u6a19\u7c64\u7269\u53ca\u5404\u7a2e\u8a55\u5206\u7cfb\u7d71\u53ef\u80fd\u6709\u52a9\u65bc\u5c07\u60a3\u8005\u6309\u98a8\u96aa\u985e\u5225\u9032\u884c\u5206\u8a3a\u4ee5\u7528\u65bc\u6297\u51dd\u4ee5\u53ca\u8a3a\u65b7 COVID-19 \u75ab\u82d7\u63a5\u7a2e\u5f8c\u7684\u51dd\u584a\u3002<\/p>\n

\u53c3\u8003\u6587\u737b\uff1a<\/em>
\n[1]<\/a> ISTH experts explain new Blood Clotting phenomenon in hospitalized COVID-19 patients\u3002<\/p>\n

\n[2]<\/a>\u00a0Scully, M.\u7b49\u4eba (2021)\u3002Pathologic Antibodies to Platelet Factor 4 after ChAdOx1 nCoV-19 Vaccination\u3002New England Journal of Medicine\u3002384\u3002\u7b2c 2202-2211 \u9801\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

COVID-19 \u611f\u67d3\u8207\u8840\u6813\u5f62\u6210\u6216\u8840\u51dd\u584a\u6709\u95dc\uff0c\u6d89\u53ca\u975c\u8108\u548c\u52d5\u8108\u3002\u5c0d\u65bc\u56e0 COVID-19 \u611f\u67d3\u800c\u5165\u9662\u7684\u60a3\u8005\uff0c\u8840\u51dd\u584a\u7684\u98a8\u96aa\u6700\u9ad8\uff0c\u767c\u751f\u5728\u7d04 5% \u7684\u5165\u4f4f\u666e\u901a\u91ab\u9662\u75c5\u623f\u7684\u60a3\u8005\u4e2d\uff0c\u4e14\u52a0\u8b77\u75c5\u623f (ICU) \u63a5\u53d7\u751f\u547d\u7dad\u6301\u6cbb\u7642\u7684\u60a3\u8005\u4e2d\u9ad8\u9054 20%\u3002\u4e0d\u9700\u8981\u5165\u9662\u7684 COVID-19 \u611f\u67d3\u8005\u767c\u751f\u8840\u6813\u7684\u98a8\u96aa\u8f03\u4f4e\u7d04 1% [1]\u3002 \u96d6\u7136\u975e\u5e38\u4e0d\u5e38\u898b\uff0c\u4f46\u4f7f\u7528\u57fa\u65bc\u817a\u75c5\u6bd2\u4e4b\u75ab\u82d7\u9032\u884c\u75ab\u82d7\u63a5\u7a2e\u4ea6\u8207\u85c9\u7531\u7a31\u70ba\u75ab\u82d7\u8a98\u5c0e\u4e4b\u8840\u6813\u6027\u8840\u5c0f\u677f\u6e1b\u5c11\u75c7 (VITT) \u4e4b\u75c5\u75c7\u5f15\u8d77\u7684\u8840\u51dd\u584a\u76f8\u95dc\u806f\u3002\u70ba\u4e86\u66f4\u78ba\u5be6\u77ad\u89e3\u95dc\u65bc COVID-19 \u75ab\u82d7\u63a5\u7a2e\u548c\u60a3\u8005\u7ba1\u7406\u7684\u4e3b\u8981\u51dd\u8840\u98a8\u96aa\u548c\u6ce8\u610f\u4e8b\u9805\uff0cRoche Diagnostics Asia Pacific \u6700\u8fd1\u8207\u65b0\u52a0\u5761\u7e3d\u91ab\u9662\u8cc7\u6df1\u9867\u554f\u517c\u8840\u6db2\u5b78\u79d1\u4e3b\u4efb Ng Heng Joo \u91ab\u5e2b\u9032\u884c\u4ea4\u8ac7\u3002 COVID-19 \u7167\u8b77\u53ca\u75ab\u82d7\u63a5\u7a2e\u5f8c\u8a55\u4f30\u4e2d\u7684\u51dd\u8840\u6a19\u7c64 \u7d2f\u7a4d\u7684\u5be6\u9a57\u5ba4\u8b49\u64da\u8868\u660e\uff0cCOVID-19 \u611f\u67d3\u60a3\u8005\u7684\u7570\u5e38\u51dd\u8840\u8b8a\u5316\u53ef\u80fd\u662f\u56b4\u91cd\u767c\u708e\u53cd\u61c9\u7684\u7d50\u679c\uff0c\u800c\u8207\u5167\u5728\u4fc3\u51dd\u4f5c\u7528\u672c\u8eab\u7121\u95dc\u3002\u91cd\u5ea6 COVID-19 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