{"id":144215,"date":"2021-03-18T05:13:28","date_gmt":"2021-03-18T05:13:28","guid":{"rendered":"https:\/\/labinsights.com\/acf_article\/%e5%86%a0%e7%8b%80%e7%97%85%e6%af%92ngs%ef%bc%88%e6%ac%a1%e4%b8%96%e4%bb%a3%e5%ae%9a%e5%ba%8f%ef%bc%89%e5%9c%a8%e5%a4%a7%e6%b5%81%e8%a1%8c%e6%9c%9f%e9%96%93%e5%a6%82%e4%bd%95%e5%bd%a2%e6%88%90\/"},"modified":"2026-01-19T06:00:49","modified_gmt":"2026-01-19T06:00:49","slug":"how-ngs-tools-have-shaped-the-covid-19-pandemic-response","status":"publish","type":"acf_article","link":"https:\/\/labinsights.com\/zhtw\/operations\/sequencing\/how-ngs-tools-have-shaped-the-covid-19-pandemic-response\/","title":{"rendered":"\u51a0\u72c0\u75c5\u6bd2NGS\uff08\u6b21\u4e16\u4ee3\u5b9a\u5e8f\uff09\u5728\u5927\u6d41\u884c\u671f\u9593\u5982\u4f55\u5f62\u6210\uff1f"},"content":{"rendered":"

\u7c21\u4ecb-\u4e0b\u4e00\u4ee3\u6e2c\u5e8fCOVID19<\/strong><\/h2>\n

\u7531\u65bc\u51a0\u72c0\u75c5\u6bd2NGS\u7684\u53ef\u7528\u6027\u548c\u53ef\u8ca0\u64d4\u6027\uff0c\u4e0b\u4e00\u4ee3\u6e2c\u5e8f(NGS)\u5df2\u6210\u70ba\u79d1\u5b78\u754c\u61c9\u5c0dCOVID-19\u5927\u6d41\u884c\u7684\u4e0d\u53ef\u6216\u7f3a\u7684\u7d44\u6210\u90e8\u5206\u3002\u57fa\u56e0\u7d44\u8cc7\u6599\u5be6\u73fe\u4e86\u524d\u6240\u672a\u6709\u7684\u75c5\u539f\u9ad4\u76e3\u6e2c\uff0c\u4e26\u57fa\u65bc\u75c5\u6bd2\u57fa\u56e0\u7d44\u5e8f\u5217\u5feb\u901f\u958b\u767c\u4e86\u8a3a\u65b7\u6aa2\u6e2c\u548c\u75ab\u82d7\u3002<\/p>\n

\u5c0dSARS-CoV-2\u57fa\u56e0\u7d44\u7684\u9996\u6b21\u89c0\u5bdf\u4f86\u81ea\u5fa9\u65e6\u5927\u5b78\u4e0a\u6d77\u516c\u5171\u885b\u751f\u81e8\u5e8a\u4e2d\u5fc3\u7684\u79d1\u5b78\u5bb6\u3002Yong-Zhen Zhang\u6559\u6388\u7387\u9818\u7684\u5718\u968a\u5c0d2019\u5e7412\u670826\u65e5\u5f9e\u6b66\u6f22\u4e00\u540d\u60a3\u8005\u8eab\u4e0a\u63a1\u96c6\u7684\u5206\u96e2\u682a\u9032\u884c\u5b9a\u5e8f\uff1b\u4ed6\u5011\u65bc2020\u5e741\u67085\u65e5\u5b8c\u6210\u57fa\u56e0\u9ad4\u7d44\u88dd\u3002 \u8a72\u57fa\u56e0\u9ad4\u5e8f\u5217\u8207\u8a72\u5718\u968a\u7684\u9577\u671f\u7814\u7a76\u5925\u4f34\u3001\u96ea\u68a8\u5927\u5b78\u75c5\u6bd2\u5b78\u5bb6Eddie Holmes\u6559\u6388\u5171\u7528\u3002\u4ed6\u57281\u670811\u65e5\u5c07\u5e8f\u5217\u4e0a\u50b3\u5230\u516c\u5171\u8cc7\u6599\u5eab\u5411\u5168\u4e16\u754c\u4ecb\u7d39\u751f\u7269\u7684\u57fa\u56e0\u7d44\u3002<\/p>\n

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\u4f46\u6e2c\u5e8f\u5de5\u4f5c\u4e26\u672a\u5c31\u6b64\u505c\u6b62\u3002\u622a\u81f32021\u5e74\u521d\uff0c\u5df2\u5c0d600,000\u591a\u500b\u75c5\u6bd2\u57fa\u56e0\u9ad4\u9032\u884c\u5b9a\u5e8f\uff0c\u4e26\u5728GISAID\u8cc7\u6599\u5eab\u4e2d\u516c\u958b\u5206\u4eab[1]\u3002\u5728\u9019\u9ebc\u77ed\u7684\u6642\u9593\u6bb5\u5167\uff0c\u4efb\u4f55\u75c5\u539f\u9ad4\u7522\u751f\u7684\u57fa\u56e0\u9ad4\u5e8f\u5217\u90fd\u66f4\u591a\u3002\u5982\u6b64\u9a5a\u4eba\u7684\u8cc7\u6599\u6536\u96c6\u4f7f\u79d1\u5b78\u5bb6\u80fd\u5920\u8ffd\u8e64\u75c5\u6bd2\u7684\u50b3\u64ad\uff0c\u6839\u64da\u7cfb\u7d71\u767c\u80b2\u8cc7\u6599\u7e6a\u88fd\u50b3\u64ad\u5730\u5716\uff0c\u6e2c\u91cf\u5176\u7a81\u8b8a\u7387\uff0c\u767c\u73fe\u65b0\u51fa\u73fe\u7684\u503c\u5f97\u95dc\u6ce8\u7684\u8b8a\u7570\u9ad4\uff0c\u4e26\u9451\u5b9a\u8d85\u7d1a\u50b3\u64ad\u4e8b\u4ef6\u3002<\/p>\n

\u5982\u679c\u6c92\u6709\u5f9e\u5982\u6b64\u4e4b\u591a\u5206\u96e2\u682a\u4e2d\u751f\u6210\u7684\u5168\u57fa\u56e0\u9ad4\u5e8f\u5217\u8cc7\u6599\uff0c\u9019\u4e9b\u6210\u5c31\u7686\u4e0d\u53ef\u80fd\u5be6\u73fe\u3002\u5728\u7f8e\u570b\u548c\u82f1\u570b\u7b49\u570b\u5bb6\/\u5730\u5340\uff0c\u5be6\u9a57\u5ba4\u5df2\u7d93\u5efa\u7acb\u4e86\u5b9a\u5e8f\u5de5\u4f5c\u6d41\u7a0b[2]\uff0c\u65e8\u5728\u5bb9\u7d0d\u904b\u884c\u5206\u5b50\u8a3a\u65b7\u6e2c\u5b9a\u5f8c\u907a\u7559\u7684\u4f4e\u9ad4\u7a4d\u6b98\u7559\u6a23\u672c\u3002\u96d6\u7136\u75ab\u60c5\u5177\u6709\u6bc0\u6ec5\u6027\uff0c\u4f46\u4f86\u81ea\u4e16\u754c\u5404\u5730\u5be6\u9a57\u5ba4\u7684NGS\u8cc7\u6599\u8ca2\u737b\u6a19\u8a8c\u8457\u75c5\u6bd2\u57fa\u56e0\u9ad4\u5b78\u7684\u9ec3\u91d1\u6642\u4ee3\u3002<\/p>\n

\u4f8b\u5982\uff0c\u65e5\u672c\u7684\u79d1\u5b78\u5bb6\u5df2\u7d93\u7522\u751f\u4e26\u516c\u958b\u5206\u4eab\u4e86\u6578\u842c\u500bSARS-CoV-2\u57fa\u56e0\u7d44\u5e8f\u5217\u3002\u9019\u4e9b\u8cc7\u8a0a\u4f7f\u4ed6\u5011\u80fd\u5920\u767c\u73fe\u6700\u521d\u5728\u82f1\u570b\u3001\u5357\u975e\u548c\u5df4\u897f\u767c\u73fe\u7684\u65b0\u8208\u8b8a\u7570\u682a\u7684\u672c\u5730\u5f15\u5165[3] \u2014\u9019\u4e9b\u8b8a\u7570\u682a\u7684\u50b3\u67d3\u6027\u9ad8\u65bc\u539f\u59cb\u6bd2\u682a\uff0c\u4e26\u53ef\u80fd\u964d\u4f4e\u67d0\u4e9b\u75ab\u82d7\u7684\u6709\u6548\u6027\u3002\u6700\u8fd1\u5f9e\u65e5\u672c\u5b58\u653e\u5230\u516c\u5171\u8cc7\u6599\u5eab\u7684\u5e8f\u5217\u4f86\u81ea\u9577\u5d0e\u5927\u5b78\u3001\u570b\u7acb\u50b3\u67d3\u75c5\u7814\u7a76\u6240\u548c\u8328\u57ce\u7e23\u516c\u5171\u885b\u751f\u7814\u7a76\u6240\u3002<\/p>\n

\u4e9e\u592a\u5730\u5340[4]\u6700\u8fd1\u7684\u5176\u4ed6\u57fa\u56e0\u9ad4\u5e8f\u5217\u8ca2\u737b\u4f86\u81ea\u5b5f\u52a0\u62c9\u3001\u6c76\u840a\u3001\u4e2d\u570b\u3001\u9999\u6e2f\u3001\u5370\u5ea6[5]\u3001\u5370\u5c3c[6]\u3001\u83f2\u5f8b\u8cd3\u3001\u97d3\u570b\u548c\u6fb3\u6d32\u3002\u4e00\u4e9b\u6a5f\u69cb\u6b63\u5728\u4f7f\u7528\u793e\u7fa4\u5a92\u9ad4\u4f86\u8b93\u4f4f\u6236\u77ad\u89e3\u6700\u65b0\u8cc7\u8a0a\u3002\u4f8b\u5982\uff0c\u83f2\u5f8b\u8cd3\u57fa\u56e0\u9ad4\u4e2d\u5fc3\u6700\u8fd1\u767c\u63a8\u6587\u7a31\uff1a\u300c\u5728\u68d8\u86cb\u767d\u5340\u57df\u5e36\u6709\u591a\u500b\u95dc\u6ce8\u7684\u7a81\u8b8a\u7684SARS-CoV-2\u8b8a\u7570\u9ad4\u9996\u5148\u5728PGC\u7684DNA\u6e2c\u5e8f\u6838\u5fc3\u8a2d\u65bd\u7d93\u7531\u5168\u57fa\u56e0\u9ad4\u6e2c\u5e8f\u88ab\u6aa2\u6e2c\u5230\uff0c\u4e26\u5728PH\u4e2d\u9032\u884c\u57fa\u56e0\u9ad4\u5b78\u7279\u6027\u5316\uff0c\u4e26\u57282021\u5e7410\u67083\u65e5\u6b63\u5f0f\u547d\u540d\u70ba\u8b5c\u7cfbP.3\u3002\u300d<\/p>\n

\u5c0d\u4ee3\u8868\u6027\u6bd4\u4f8b\u7684COVID-19\u75c5\u4f8b\u9032\u884c\u5b9a\u5e8f\u7684\u570b\u5bb6\/\u5730\u5340\u63d0\u4f9b\u4e86\u6709\u95dc\u75c5\u6bd2\u5982\u4f55\u6f14\u8b8a\u4ee5\u53ca\u54ea\u4e9b\u7a81\u8b8a\u53ef\u80fd\u6700\u4ee4\u4eba\u64d4\u6182\u7684\u95dc\u9375\u8cc7\u8a0a\u3002\u4f8b\u5982\uff0c\u6700\u521d\u5728\u82f1\u570b\u6aa2\u6e2c\u5230\u7684B.1.1.7\u8b8a\u7570\u9ad4\u548c\u6700\u521d\u5728\u5357\u975e\u767c\u73fe\u7684B.1.351\u8b8a\u7570\u9ad4\u5747\u5305\u542b\u6bd4\u57fa\u65bcSARS-CoV-2\u6a19\u6e96\u9032\u5316\u7387\u9810\u671f\u7684\u7a81\u8b8a\u591a\u5f97\u591a\u7684\u7a81\u8b8a[7]\uff0c\u5c0e\u81f4\u79d1\u5b78\u5bb6\u63a8\u6e2c\uff0c\u9019\u4e9b\u66f4\u5177\u50b3\u67d3\u6027\u7684\u8b8a\u7570\u9ad4\u53ef\u80fd\u5df2\u5728\u611f\u67d3\u6642\u9593\u5ef6\u9577\u7684\u60a3\u8005\u4e2d\u9032\u5316[8]\u3002\u5927\u91cf\u7a81\u8b8a\u53ef\u80fd\u53cd\u6620\u4e86\u75c5\u6bd2\u5c0d\u4f86\u81ea\u514d\u75ab\u7cfb\u7d71\u7684\u5de8\u5927\u4e14\u91cd\u8907\u7684\u9078\u64c7\u6027\u58d3\u529b\u4f5c\u51fa\u53cd\u61c9\u3002<\/p>\n

\u5728\u4e00\u4e9b\u570b\u5bb6\uff0cNGS\u5de5\u5177\u4e5f\u88ab\u90e8\u7f72\u7528\u65bc\u793e\u7fa4\u76e3\u6e2c\u8a08\u756b\uff0c\u901a\u5e38\u57fa\u65bc\u5ee2\u6c34[9]\u3002\u793e\u7fa4\u5ee2\u6c34\u4e2d\u75c5\u6bd2\u591a\u6a23\u6027\u548c\u6578\u91cf\u65b9\u9762\u7684\u8da8\u52e2\u901a\u5e38\u9810\u793a\u8457\u5e7e\u9031\u5f8c\u5728\u9019\u4e9b\u5730\u5340\u81e8\u5e8a\u4e0a\u5c07\u770b\u5230\u7684\u60c5\u6cc1\uff1b\u9019\u4e9b\u8cc7\u8a0a\u53ef\u4ee5\u5e6b\u52a9\u6307\u5c0e\u516c\u5171\u885b\u751f\u653f\u7b56\uff0c\u5c24\u5176\u662f\u5340\u57df\u5c01\u9396\u7b49\u7de9\u89e3\u63aa\u65bd\u3002<\/p>\n

\u53e6\u5916\uff0c\u4e00\u500b\u540d\u70baMetaSUB [10]\u7684\u5fd7\u5de5\u9a45\u52d5\u5c08\u6848\u4f7f\u7528\u5f9e\u5168\u7403\u57ce\u5e02\u4e2d\u4ea4\u901a\u7cfb\u7d71\u7b49\u516c\u5171\u5834\u6240\u6536\u96c6\u7684\u6a23\u54c1\u7684\u5b8f\u57fa\u56e0\u7d44\u6e2c\u5e8f\u3002\u53bb\u5e74\uff0c\u9019\u4e9b\u6a23\u672c\u5305\u62ecSARS-CoV-2\u57fa\u56e0\u9ad4\uff0c\u8cc7\u6599\u8207\u9019\u4e9b\u5730\u5340\u7684\u81e8\u5e8a\u8da8\u52e2\u57fa\u672c\u76f8\u7b26\u3002<\/p>\n

\u300c\u96a8\u8457\u8d8a\u4f86\u8d8a\u591a\u7684\u570b\u5bb6\u958b\u59cb\u5be6\u65bd\u5b9a\u5e8f\u8a08\u756b\uff0c\u5c07\u6709\u66f4\u591a\u6a5f\u6703\u66f4\u597d\u5730\u77ad\u89e3\u65b0\u8208\u75c5\u539f\u9ad4\u7684\u4e16\u754c\uff0c\u4ee5\u53ca\u5b83\u5011\u5728\u5404\u7a2e\u6c23\u5019\u3001\u751f\u614b\u7cfb\u7d71\u3001\u6587\u5316\u3001\u751f\u6d3b\u65b9\u5f0f\u53ca\u751f\u7269\u7fa4\u843d\u4e2d\u8207\u4eba\u985e\u548c\u52d5\u7269\u7684\u76f8\u4e92\u4f5c\u7528\u300d\uff0c\u4e16\u754c\u885b\u751f\u7d44\u7e54\u5168\u7403\u50b3\u67d3\u6027\u5371\u5bb3\u9632\u7bc4\u4e3b\u4efbSylvie Briand\u5728\u6700\u8fd1\u767c\u4f48\u7684\u4f7f\u7528SARS-CoV-2\u57fa\u56e0\u9ad4\u5b9a\u5e8f\u6307\u5357\u4e2d\u5beb\u9053[11]\u3002\u300c\u5982\u679c\u6211\u5011\u60f3\u70ba\u672a\u4f86\u7684\u5a01\u8105\u505a\u597d\u66f4\u5145\u5206\u7684\u6e96\u5099\uff0c\u5c31\u5fc5\u9808\u52a0\u901f\u5c07\u57fa\u56e0\u7d44\u6e2c\u5e8f\u878d\u5165\u5168\u7403\u885b\u751f\u754c\u7684\u505a\u6cd5\u3002\u300d<\/p>\n

COVID-19\u5927\u6d41\u884c\u75ab\u60c5\u51f8\u986f\u4e86\u5168\u57fa\u56e0\u7d44\u5b9a\u5e8f\u7684\u50f9\u503c\u4ee5\u53ca\u524d\u77bb\u6027\u50b3\u67d3\u75c5\u76e3\u6e2c\u7684\u5fc5\u8981\u6027\uff0c\u4ee5\u5728\u65b0\u7684\u3001\u65b0\u51fa\u73fe\u7684\u75be\u75c5\u5728\u5168\u7403\u50b3\u64ad\u4e4b\u524d\u5c0d\u5176\u9032\u884c\u6aa2\u6e2c\u3002\u6295\u8cc7\u9069\u7576\u7684\u8cc7\u6e90\u4e26\u5efa\u7acb\u76e3\u6e2c\u57fa\u790e\u8a2d\u65bd\u81f3\u95dc\u91cd\u8981\uff0c\u4ee5\u78ba\u4fdd\u6211\u5011\u70ba\u61c9\u5c0d\u4e0b\u4e00\u6b21\u5927\u6d41\u884c\u5a01\u8105\u505a\u597d\u66f4\u5145\u5206\u7684\u6e96\u5099\u3002<\/p>\n

\u57fa\u56e0\u7d44\u76e3\u6e2c\u548c\u6d41\u884c\u75c5\u5b78\u53ea\u662f\u5be6\u9a57\u5ba4\u8a3a\u65b7\u5982\u4f55\u652f\u63f4COVID-19\u7ba1\u7406\u7684\u4e00\u500b\u4f8b\u5b50\u3002\u5982\u9700\u77ad\u89e3\u66f4\u591a\u6709\u95dc\u5404\u7a2e\u6a5f\u6703\u7684\u8cc7\u8a0a\uff0c\u8acb\u53c3\u95b1 \u4e9e\u592a\u91ab\u7642\u6280\u8853\u5354\u6703(APACMed)\u7684\u65b0\u5831\u544a\u300a\u8a3a\u65b7\u5728COVID-19\u7ba1\u7406\u4e2d\u7684\u95dc\u9375\u4f5c\u7528\u300b<\/a>\u3002<\/em><\/p>\n

\u53c3\u8003\u6587\u737b\uff1a<\/em><\/p>\n

[1]<\/a> GISAID\u8cc7\u6599\u5eab<\/p>\n

[2]<\/a> \u6851\u683c\u7814\u7a76\u6240\u7684COVID-19\u5b9a\u5e8f\uff0c\u6851\u683c\u7814\u7a76\u6240\u90e8\u843d\u683c<\/p>\n

[3]<\/a> \u8a3a\u65b7\u5b78\u5728COVID-19\u7ba1\u7406\u4e2d\u7684\u95dc\u9375\u4f5c\u7528\uff0cAPACMed<\/p>\n

[4]<\/a> \u65b0\u578b\u51a0\u72c0\u75c5\u6bd2\u4e4b\u57fa\u56e0\u9ad4\u6d41\u884c\u75c5\u5b78-\u4ee5\u4e9e\u6d32\u70ba\u4e2d\u5fc3\u4e4b\u6b21\u53d6\u6a23\uff0cNextstrain<\/p>\n

[5]<\/a> \u300c\u51a0\u72c0\u75c5\u6bd2\uff1a\u5370\u5ea6\u5728\u65b0\u51a0\u75ab\u60c5\u903c\u8fd1\u4e4b\u969b\u5c0b\u627e\u65b0\u6bd2\u682a\u300d\uff0cBBC<\/p>\n

[6]<\/a> \u300c\u5370\u5c3c\u52a0\u5927\u529b\u5ea6\u767c\u73fe\u96e3\u4ee5\u6349\u6478\u7684COVID\u8b8a\u7570\u682a\u300d\uff0c\u65e5\u7d93\u4e9e\u6d32<\/p>\n

[7]<\/a> \u300c\u00a0\u4e94\u7a2e\u65b0\u51fa\u73fe\u7684\u51a0\u72c0\u75c5\u6bd2\u8b8a\u7570\u9ad4\u4e2d\u6700\u4ee4\u4eba\u64d4\u6182\u7684\u7a81\u8b8a\u300d\uff0c\u79d1\u5b78\u7f8e\u570b\u4eba<\/p>\n

[8]<\/a> \u300c\u52a0\u901f\u6f14\u8b8a\u7684\u7194\u7210\u300d\uff1aCovid-19\u764c\u75c7\u60a3\u8005HIV\u53ef\u80fd\u5728\u8b8a\u7570\u9ad4\u7684\u51fa\u73fe\u4e2d\u767c\u63ee\u4f5c\u7528\uff0c\u300a\u83ef\u76db\u9813\u90f5\u5831\u300b<\/p>\n

[9]<\/a> \u300c\u5229\u7528\u5ee2\u6c34\u8ffd\u8e64\u65b0\u51a0\u75c5\u6bd2COVID-19\u300d\uff0cNature Biotechnology<\/p>\n

[10]<\/a> MetaSUB\u96c6\u5718<\/p>\n

[11]<\/a> \u4e16\u754c\u885b\u751f\u7d44\u7e54SARS-CoV-2\u57fa\u56e0\u9ad4\u5b9a\u5e8f\u6307\u5357<\/p>\n

\n","protected":false},"excerpt":{"rendered":"

\u7c21\u4ecb-\u4e0b\u4e00\u4ee3\u6e2c\u5e8fCOVID19 \u7531\u65bc\u51a0\u72c0\u75c5\u6bd2NGS\u7684\u53ef\u7528\u6027\u548c\u53ef\u8ca0\u64d4\u6027\uff0c\u4e0b\u4e00\u4ee3\u6e2c\u5e8f(NGS)\u5df2\u6210\u70ba\u79d1\u5b78\u754c\u61c9\u5c0dCOVID-19\u5927\u6d41\u884c\u7684\u4e0d\u53ef\u6216\u7f3a\u7684\u7d44\u6210\u90e8\u5206\u3002\u57fa\u56e0\u7d44\u8cc7\u6599\u5be6\u73fe\u4e86\u524d\u6240\u672a\u6709\u7684\u75c5\u539f\u9ad4\u76e3\u6e2c\uff0c\u4e26\u57fa\u65bc\u75c5\u6bd2\u57fa\u56e0\u7d44\u5e8f\u5217\u5feb\u901f\u958b\u767c\u4e86\u8a3a\u65b7\u6aa2\u6e2c\u548c\u75ab\u82d7\u3002 \u5c0dSARS-CoV-2\u57fa\u56e0\u7d44\u7684\u9996\u6b21\u89c0\u5bdf\u4f86\u81ea\u5fa9\u65e6\u5927\u5b78\u4e0a\u6d77\u516c\u5171\u885b\u751f\u81e8\u5e8a\u4e2d\u5fc3\u7684\u79d1\u5b78\u5bb6\u3002Yong-Zhen Zhang\u6559\u6388\u7387\u9818\u7684\u5718\u968a\u5c0d2019\u5e7412\u670826\u65e5\u5f9e\u6b66\u6f22\u4e00\u540d\u60a3\u8005\u8eab\u4e0a\u63a1\u96c6\u7684\u5206\u96e2\u682a\u9032\u884c\u5b9a\u5e8f\uff1b\u4ed6\u5011\u65bc2020\u5e741\u67085\u65e5\u5b8c\u6210\u57fa\u56e0\u9ad4\u7d44\u88dd\u3002 \u8a72\u57fa\u56e0\u9ad4\u5e8f\u5217\u8207\u8a72\u5718\u968a\u7684\u9577\u671f\u7814\u7a76\u5925\u4f34\u3001\u96ea\u68a8\u5927\u5b78\u75c5\u6bd2\u5b78\u5bb6Eddie Holmes\u6559\u6388\u5171\u7528\u3002\u4ed6\u57281\u670811\u65e5\u5c07\u5e8f\u5217\u4e0a\u50b3\u5230\u516c\u5171\u8cc7\u6599\u5eab\u5411\u5168\u4e16\u754c\u4ecb\u7d39\u751f\u7269\u7684\u57fa\u56e0\u7d44\u3002 \u8a72\u5e8f\u5217\u8cc7\u6599\u7acb\u5373\u7528\u65bc\u75ab\u82d7\u958b\u767c\u5de5\u4f5c\uff0c\u70ba\u5728\u81e8\u5e8a\u8a66\u9a57\u4e4b\u5916\u4f7f\u7528\u7684\u6700\u65e9\u5169\u7a2emRNA\u75ab\u82d7\u5960\u5b9a\u4e86\u57fa\u790e\u3002\u5b83\u4e5f\u662f\u4eca\u5929\u4f7f\u7528\u7684\u8a31\u591aSARS-CoV-2\u8a3a\u65b7\u6aa2\u6e2c\u7684\u57fa\u790e\u3002 \u4f46\u6e2c\u5e8f\u5de5\u4f5c\u4e26\u672a\u5c31\u6b64\u505c\u6b62\u3002\u622a\u81f32021\u5e74\u521d\uff0c\u5df2\u5c0d600,000\u591a\u500b\u75c5\u6bd2\u57fa\u56e0\u9ad4\u9032\u884c\u5b9a\u5e8f\uff0c\u4e26\u5728GISAID\u8cc7\u6599\u5eab\u4e2d\u516c\u958b\u5206\u4eab[1]\u3002\u5728\u9019\u9ebc\u77ed\u7684\u6642\u9593\u6bb5\u5167\uff0c\u4efb\u4f55\u75c5\u539f\u9ad4\u7522\u751f\u7684\u57fa\u56e0\u9ad4\u5e8f\u5217\u90fd\u66f4\u591a\u3002\u5982\u6b64\u9a5a\u4eba\u7684\u8cc7\u6599\u6536\u96c6\u4f7f\u79d1\u5b78\u5bb6\u80fd\u5920\u8ffd\u8e64\u75c5\u6bd2\u7684\u50b3\u64ad\uff0c\u6839\u64da\u7cfb\u7d71\u767c\u80b2\u8cc7\u6599\u7e6a\u88fd\u50b3\u64ad\u5730\u5716\uff0c\u6e2c\u91cf\u5176\u7a81\u8b8a\u7387\uff0c\u767c\u73fe\u65b0\u51fa\u73fe\u7684\u503c\u5f97\u95dc\u6ce8\u7684\u8b8a\u7570\u9ad4\uff0c\u4e26\u9451\u5b9a\u8d85\u7d1a\u50b3\u64ad\u4e8b\u4ef6\u3002 \u5982\u679c\u6c92\u6709\u5f9e\u5982\u6b64\u4e4b\u591a\u5206\u96e2\u682a\u4e2d\u751f\u6210\u7684\u5168\u57fa\u56e0\u9ad4\u5e8f\u5217\u8cc7\u6599\uff0c\u9019\u4e9b\u6210\u5c31\u7686\u4e0d\u53ef\u80fd\u5be6\u73fe\u3002\u5728\u7f8e\u570b\u548c\u82f1\u570b\u7b49\u570b\u5bb6\/\u5730\u5340\uff0c\u5be6\u9a57\u5ba4\u5df2\u7d93\u5efa\u7acb\u4e86\u5b9a\u5e8f\u5de5\u4f5c\u6d41\u7a0b[2]\uff0c\u65e8\u5728\u5bb9\u7d0d\u904b\u884c\u5206\u5b50\u8a3a\u65b7\u6e2c\u5b9a\u5f8c\u907a\u7559\u7684\u4f4e\u9ad4\u7a4d\u6b98\u7559\u6a23\u672c\u3002\u96d6\u7136\u75ab\u60c5\u5177\u6709\u6bc0\u6ec5\u6027\uff0c\u4f46\u4f86\u81ea\u4e16\u754c\u5404\u5730\u5be6\u9a57\u5ba4\u7684NGS\u8cc7\u6599\u8ca2\u737b\u6a19\u8a8c\u8457\u75c5\u6bd2\u57fa\u56e0\u9ad4\u5b78\u7684\u9ec3\u91d1\u6642\u4ee3\u3002 \u4f8b\u5982\uff0c\u65e5\u672c\u7684\u79d1\u5b78\u5bb6\u5df2\u7d93\u7522\u751f\u4e26\u516c\u958b\u5206\u4eab\u4e86\u6578\u842c\u500bSARS-CoV-2\u57fa\u56e0\u7d44\u5e8f\u5217\u3002\u9019\u4e9b\u8cc7\u8a0a\u4f7f\u4ed6\u5011\u80fd\u5920\u767c\u73fe\u6700\u521d\u5728\u82f1\u570b\u3001\u5357\u975e\u548c\u5df4\u897f\u767c\u73fe\u7684\u65b0\u8208\u8b8a\u7570\u682a\u7684\u672c\u5730\u5f15\u5165[3] \u2014\u9019\u4e9b\u8b8a\u7570\u682a\u7684\u50b3\u67d3\u6027\u9ad8\u65bc\u539f\u59cb\u6bd2\u682a\uff0c\u4e26\u53ef\u80fd\u964d\u4f4e\u67d0\u4e9b\u75ab\u82d7\u7684\u6709\u6548\u6027\u3002\u6700\u8fd1\u5f9e\u65e5\u672c\u5b58\u653e\u5230\u516c\u5171\u8cc7\u6599\u5eab\u7684\u5e8f\u5217\u4f86\u81ea\u9577\u5d0e\u5927\u5b78\u3001\u570b\u7acb\u50b3\u67d3\u75c5\u7814\u7a76\u6240\u548c\u8328\u57ce\u7e23\u516c\u5171\u885b\u751f\u7814\u7a76\u6240\u3002 \u4e9e\u592a\u5730\u5340[4]\u6700\u8fd1\u7684\u5176\u4ed6\u57fa\u56e0\u9ad4\u5e8f\u5217\u8ca2\u737b\u4f86\u81ea\u5b5f\u52a0\u62c9\u3001\u6c76\u840a\u3001\u4e2d\u570b\u3001\u9999\u6e2f\u3001\u5370\u5ea6[5]\u3001\u5370\u5c3c[6]\u3001\u83f2\u5f8b\u8cd3\u3001\u97d3\u570b\u548c\u6fb3\u6d32\u3002\u4e00\u4e9b\u6a5f\u69cb\u6b63\u5728\u4f7f\u7528\u793e\u7fa4\u5a92\u9ad4\u4f86\u8b93\u4f4f\u6236\u77ad\u89e3\u6700\u65b0\u8cc7\u8a0a\u3002\u4f8b\u5982\uff0c\u83f2\u5f8b\u8cd3\u57fa\u56e0\u9ad4\u4e2d\u5fc3\u6700\u8fd1\u767c\u63a8\u6587\u7a31\uff1a\u300c\u5728\u68d8\u86cb\u767d\u5340\u57df\u5e36\u6709\u591a\u500b\u95dc\u6ce8\u7684\u7a81\u8b8a\u7684SARS-CoV-2\u8b8a\u7570\u9ad4\u9996\u5148\u5728PGC\u7684DNA\u6e2c\u5e8f\u6838\u5fc3\u8a2d\u65bd\u7d93\u7531\u5168\u57fa\u56e0\u9ad4\u6e2c\u5e8f\u88ab\u6aa2\u6e2c\u5230\uff0c\u4e26\u5728PH\u4e2d\u9032\u884c\u57fa\u56e0\u9ad4\u5b78\u7279\u6027\u5316\uff0c\u4e26\u57282021\u5e7410\u67083\u65e5\u6b63\u5f0f\u547d\u540d\u70ba\u8b5c\u7cfbP.3\u3002\u300d \u5c0d\u4ee3\u8868\u6027\u6bd4\u4f8b\u7684COVID-19\u75c5\u4f8b\u9032\u884c\u5b9a\u5e8f\u7684\u570b\u5bb6\/\u5730\u5340\u63d0\u4f9b\u4e86\u6709\u95dc\u75c5\u6bd2\u5982\u4f55\u6f14\u8b8a\u4ee5\u53ca\u54ea\u4e9b\u7a81\u8b8a\u53ef\u80fd\u6700\u4ee4\u4eba\u64d4\u6182\u7684\u95dc\u9375\u8cc7\u8a0a\u3002\u4f8b\u5982\uff0c\u6700\u521d\u5728\u82f1\u570b\u6aa2\u6e2c\u5230\u7684B.1.1.7\u8b8a\u7570\u9ad4\u548c\u6700\u521d\u5728\u5357\u975e\u767c\u73fe\u7684B.1.351\u8b8a\u7570\u9ad4\u5747\u5305\u542b\u6bd4\u57fa\u65bcSARS-CoV-2\u6a19\u6e96\u9032\u5316\u7387\u9810\u671f\u7684\u7a81\u8b8a\u591a\u5f97\u591a\u7684\u7a81\u8b8a[7]\uff0c\u5c0e\u81f4\u79d1\u5b78\u5bb6\u63a8\u6e2c\uff0c\u9019\u4e9b\u66f4\u5177\u50b3\u67d3\u6027\u7684\u8b8a\u7570\u9ad4\u53ef\u80fd\u5df2\u5728\u611f\u67d3\u6642\u9593\u5ef6\u9577\u7684\u60a3\u8005\u4e2d\u9032\u5316[8]\u3002\u5927\u91cf\u7a81\u8b8a\u53ef\u80fd\u53cd\u6620\u4e86\u75c5\u6bd2\u5c0d\u4f86\u81ea\u514d\u75ab\u7cfb\u7d71\u7684\u5de8\u5927\u4e14\u91cd\u8907\u7684\u9078\u64c7\u6027\u58d3\u529b\u4f5c\u51fa\u53cd\u61c9\u3002 \u5728\u4e00\u4e9b\u570b\u5bb6\uff0cNGS\u5de5\u5177\u4e5f\u88ab\u90e8\u7f72\u7528\u65bc\u793e\u7fa4\u76e3\u6e2c\u8a08\u756b\uff0c\u901a\u5e38\u57fa\u65bc\u5ee2\u6c34[9]\u3002\u793e\u7fa4\u5ee2\u6c34\u4e2d\u75c5\u6bd2\u591a\u6a23\u6027\u548c\u6578\u91cf\u65b9\u9762\u7684\u8da8\u52e2\u901a\u5e38\u9810\u793a\u8457\u5e7e\u9031\u5f8c\u5728\u9019\u4e9b\u5730\u5340\u81e8\u5e8a\u4e0a\u5c07\u770b\u5230\u7684\u60c5\u6cc1\uff1b\u9019\u4e9b\u8cc7\u8a0a\u53ef\u4ee5\u5e6b\u52a9\u6307\u5c0e\u516c\u5171\u885b\u751f\u653f\u7b56\uff0c\u5c24\u5176\u662f\u5340\u57df\u5c01\u9396\u7b49\u7de9\u89e3\u63aa\u65bd\u3002 \u53e6\u5916\uff0c\u4e00\u500b\u540d\u70baMetaSUB [10]\u7684\u5fd7\u5de5\u9a45\u52d5\u5c08\u6848\u4f7f\u7528\u5f9e\u5168\u7403\u57ce\u5e02\u4e2d\u4ea4\u901a\u7cfb\u7d71\u7b49\u516c\u5171\u5834\u6240\u6536\u96c6\u7684\u6a23\u54c1\u7684\u5b8f\u57fa\u56e0\u7d44\u6e2c\u5e8f\u3002\u53bb\u5e74\uff0c\u9019\u4e9b\u6a23\u672c\u5305\u62ecSARS-CoV-2\u57fa\u56e0\u9ad4\uff0c\u8cc7\u6599\u8207\u9019\u4e9b\u5730\u5340\u7684\u81e8\u5e8a\u8da8\u52e2\u57fa\u672c\u76f8\u7b26\u3002 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