{"id":149976,"date":"2026-01-27T08:25:31","date_gmt":"2026-01-27T08:25:31","guid":{"rendered":"https:\/\/labinsights.com\/acf_article\/%e6%95%b8%e4%bd%8d%e7%b5%a6%e8%97%a5%e8%88%87%e6%b2%bb%e7%99%82%e8%97%a5%e7%89%a9%e7%9b%a3%e6%b8%ac%e7%9a%84%e6%9c%aa%e4%be%86%ef%bc%9a%e7%ac%ac23%e5%b1%86iatdmct%e5%a4%a7%e6%9c%83%e7%9a%84%e8%a6%8b\/"},"modified":"2026-03-15T08:05:37","modified_gmt":"2026-03-15T08:05:37","slug":"digital-dosing-and-the-future-of-therapeutic-drug-monitoring-insights-from-the-23rd-iatdmct-congress","status":"publish","type":"acf_article","link":"https:\/\/labinsights.com\/zhtw\/event-coverage\/conferences\/digital-dosing-and-the-future-of-therapeutic-drug-monitoring-insights-from-the-23rd-iatdmct-congress\/","title":{"rendered":"\u6578\u4f4d\u7d66\u85e5\u8207\u6cbb\u7642\u85e5\u7269\u76e3\u6e2c\u7684\u672a\u4f86\uff1a\u7b2c23\u5c46IATDMCT\u5927\u6703\u7684\u898b\u89e3"},"content":{"rendered":"<p><span style=\"font-weight: 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Legg \u535a\u58eb\u63a2\u8a0e\u4e86\u4eba\u5de5\u667a\u6167\uff08AI\uff09\u548c\u5927\u6578\u64da\u5728\u91cd\u5851 TDM \u7814\u7a76\u4e2d\u7684\u7b56\u7565\u89d2\u8272\uff0c\u5f37\u8abf\u52d5\u614b\u9810\u6e2c\u6a21\u578b\u7684\u5fc5\u8981\u6027\u3002Lab Insights\u5718\u968a\u6ce8\u610f\u5230\u5f9e\u56db\u5834\u6df1\u5165\u7684\u6f14\u8b1b\u4e2d\u5f97\u51fa\u7684\u95dc\u9375\u898b\u89e3\uff0c\u9019\u4e9b\u6f14\u8b1b\u5c55\u793a\u4e86TDM\u548c\u81e8\u5e8a\u6bd2\u7406\u5b78\u6578\u4f4d\u5316\u7684\u591a\u5c64\u9762\u65b9\u6cd5\uff0c\u9a57\u8b49\u4e86\u5176\u5728\u9081\u5411\u500b\u4eba\u5316\u7167\u8b77\u4e2d\u7684\u4f5c\u7528\uff1a<\/span><\/p>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li><span style=\"font-weight: 400;\">Amy Legg\u535a\u58eb\u63a2\u7d22\u4e86\u4eba\u5de5\u667a\u6167(AI)\u548c<\/span> <span style=\"font-weight: 400;\">\u5927\u8cc7\u6599\u5728\u91cd\u5851TDM\u7814\u7a76\u4e2d\u7684\u6230\u7565\u4f5c\u7528\uff0c\u5f37\u8abf\u4e86\u5c0d\u52d5\u614b\u9810\u6e2c\u6a21\u578b\u7684\u9700\u6c42\u3002\u5979\u7684\u5de5\u4f5c\u690d\u6839\u65bc\u81e8\u5e8a\u85e5\u5291\u5b78\u548c\u6297\u83cc\u7ba1\u7406\uff0c\u5f37\u8abf\u5c07\u7814\u7a76\u5d4c\u5165\u6578\u4f4d\u96fb\u5b50\u5065\u5eb7\u8a18\u9304(EHR)\u7cfb\u7d71\u7684\u6f5b\u529b\uff0c\u4ee5\u89e3\u6c7a\u8907\u96dc\u7684\u81e8\u5e8a\u554f\u984c\uff0c\u5f9e\u7f55\u898b\u7684\u85e5\u7269\u4e92\u52d5\u4f5c\u7528\u5230\u7fa4\u9ad4\u7279\u7570\u6027PK\u3002<\/span><\/li>\n<\/ul>\n<\/li>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u5c71\u7530\u670b\u4e4b\u535a\u58eb\u5c55\u793a\u4e86\u5982\u4f55\u5229\u7528\u5927\u91cf\u771f\u5be6\u4e16\u754c\u8cc7\u6599\u4f86\u6e90(RWD)\u63d0\u4f9b\u95dc\u9375\u7684\u5b89\u5168\u6027\u8a0a\u865f\u4e26\u63a8\u9032\u6bd2\u7406\u5b78\u548c\u85e5\u7269\u76e3\u6e2c\u7684\u81e8\u5e8a\u5be6\u8e10\u3002\u4f5c\u70ba\u9818\u5c0e\u85e5\u7269\u8b66\u6212\u5de5\u4f5c\u7684\u9996\u5e2d\u85e5\u5291\u5e2b\uff0c\u5c71\u7530\u535a\u58eb\u7684\u500b\u6848\u7814\u7a76-\u4f8b\u5982\u8a55\u4f30\u9054\u6258\u9ef4\u7d20-\u4ed6\u6c40\u985e\u85e5\u7269\u4e92\u52d5\u4f5c\u7528\uff0c\u4ee5\u53ca\u5f8c\u7e8cTDM\u8a55\u4f30\u4ee5\u964d\u4f4e\u842c\u53e4\u9ef4\u7d20\u6bd2\u6027\u2014\u2014\u8b49\u660e\u4e86RWD\u5206\u6790\u5c0d\u60a3\u8005\u7d50\u679c\u7684\u5be6\u8cea\u5f71\u97ff\u3002<\/span><\/li>\n<\/ul>\n<\/li>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dirk Jan Moes\u535a\u58eb\u8a73\u7d30\u8aaa\u660e\u4e86\u816b\u7624\u5b78\u4e2d\u8907\u96dc\u751f\u7269\u88fd\u5291MIPD\u6230\u7565\u61c9\u7528\u7684\u6a21\u578b\u77e5\u60c5\u7cbe\u5bc6\u5ea6\u7d66\u85e5\uff0c\u5f37\u8abf\u4e86\u6574\u5408\u6578\u4f4d\u7cfb\u7d71\u7684\u53ef\u91cf\u5316\u8ca1\u52d9\u8207\u81e8\u5e8a\u6548\u76ca\u3002\u4f5c\u70ba\u81e8\u5e8a\u85e5\u7269\u8a08\u91cf\u5b78\u526f\u6559\u6388\uff0cMoes\u535a\u58eb\u5c08\u6ce8\u65bcMIPD\u7b56\u7565\u5982\u4f55\u5be6\u73fe\u7279\u5b9a\u751f\u7269\u88fd\u5291\uff08\u5305\u62ec\u9054\u96f7\u6728\u55ae\u6297\u53ca\u7d0d\u6b66\u5229\u5c24\u55ae\u6297\uff09\u7684\u7d66\u85e5\u500b\u4eba\u5316\uff0c\u5f9e\u800c\u6e1b\u5c11\u8ca1\u52d9\u8207\u81e8\u5e8a\u6bd2\u6027\u98a8\u96aa\u3002<\/span><\/li>\n<\/ul>\n<\/li>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tomoyuki Mizuno\u91ab\u5e2b\u5c55\u793a\u4e86\u6a5f\u5668\u5b78\u7fd2(ML)\u548c\u6574\u5408\u6c7a\u7b56\u652f\u63f4\u5100\u8868\u677f\u7684\u5c16\u7aef\u61c9\u7528\uff0c\u4ee5\u4fc3\u9032\u8d85\u7cbe\u78ba\u7d66\u85e5\uff0c\u7279\u5225\u662f\u5728\u5177\u6709\u6311\u6230\u6027\u7684\u5152\u79d1\u60a3\u8005\u7167\u8b77\u74b0\u5883\u4e2d\u3002Mizuno\u535a\u58eb\u9818\u5c0e\u8457\u4e00\u5bb6\u5353\u8d8a\u85e5\u7269\u6e2c\u91cf\u4e2d\u5fc3\uff0c\u5c08\u6ce8\u65bc\u4f7f\u7528ML\u589e\u5f37MIPD\u67b6\u69cb\uff0c\u4ee5\u89e3\u6c7a\u5152\u7ae5\u7d66\u85e5\u7684\u7368\u7279\u8907\u96dc\u6027\uff0c\u70ba\u81e8\u5e8a\u91ab\u5e2b\u63d0\u4f9b\u5275\u65b0\u7684\u5e8a\u908a\u5de5\u5177\u3002<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">\u9019\u4e9b\u5c08\u5bb6\u5171\u540c\u95e1\u660e\u4e86\u754c\u5b9a\u4e0b\u4e00\u4ee3\u8a3a\u65b7\u50f9\u503c\u548c\u75c5\u60a3\u7167\u8b77\u7684\u57fa\u672c\u6578\u4f4d\u652f\u67f1\u3002<\/span><\/p>\n<h2 style=\"font-family: Inter !important; font-weight: 500 !important; font-size: 28px !important; line-height: 36px !important; letter-spacing: 0px !important;\">\u6a21\u578b\u77e5\u60c5\u7cbe\u5bc6\u5ea6\u7d66\u85e5(MIPD)\u4f5c\u70ba\u57fa\u790e\u5e73\u53f0<\/h2>\n<p><span style=\"font-weight: 400;\">\u6c92\u6709\u5169\u500b\u8eab\u9ad4\u5b8c\u5168\u76f8\u540c\uff0c\u81e8\u5e8a\u4e0a\u9700\u8981\u9032\u884c\u500b\u9ad4\u5316\u3002\u300c\u6211\u5011\u7684\u8eab\u9ad4\u4e0d\u662f\u4e00\u500b\u540c\u8cea\u7684\u9b5a\u7f38\u3002\u65b0\u52a0\u5761\u7e3d\u91ab\u9662\u7684\u5b89\u5fb7\u70c8\u00b7\u5938\u6559\u6388\u5728\u4e3b\u65e8\u6f14\u8b1b\u4e2d\u5f37\u8abf\uff1a\u300c\u85e5\u7269\u7684\u5206\u914d\u65b9\u5f0f\u4e0d\u540c\u3002\u300d\u7cbe\u78ba\u7d66\u85e5\u7684\u76ee\u6a19\u662f\u78ba\u5b9a\u6700\u7406\u60f3\u7684\u7d66\u85e5\u65b9\u6848\uff0c\u8a72\u65b9\u6848\u5c07\u5728\u6bcf\u500b\u500b\u9ad4\u60a3\u8005\u4e2d\u63d0\u4f9b\u6240\u9700\u7684\u529f\u6548\u548c\u6700\u5c0f\u7684\u6bd2\u6027[1]\u3002MIPD\u5df2\u6210\u70ba\u5be6\u73fe\u6b64\u76ee\u6a19\u4e4b\u57fa\u672c\u5b9a\u91cf\u67b6\u69cb\u3002\u5176\u5229\u7528\u8907\u96dc\u7684\u85e5\u7269\u52d5\u529b\u5b78\/\u85e5\u6548\u5b78(PK\/PD)\u6a21\u578b\u4f86\u6574\u5408\u53ca\u63a1\u7528\u60a3\u8005\u7279\u5b9a\u7684\u8cc7\u8a0a\u53ca\u81e8\u5e8a\u89c0\u5bdf\uff0c\u5728\u6574\u500b\u85e5\u7269\u7642\u6cd5\u4e2d\u4ee5\u591a\u500b\u6b65\u9a5f\u4f86\u500b\u9ad4\u5316\u5291\u91cf\u3002<\/span> <span style=\"font-weight: 400;\">\u6b64\u65b9\u6cd5\u7528\u4f5c\u9810\u6e2c\u3001\u78ba\u8a8d\u3001\u5b78\u7fd2\u53ca\u61c9\u7528\u9031\u671f\uff1a<\/span><\/p>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u9810\u6e2c\uff08\u524d\u671f\u5291\u91cf\u8abf\u9069\uff09\uff1a<\/b><span style=\"font-weight: 400;\">\u57fa\u7dda\u60a3\u8005\u8cc7\u6599\uff08\u8af8\u5982\u9ad4\u91cd\u3001\u5e74\u9f61\u3001\u57fa\u56e0\u7d44\u6210\u53ca\u5668\u5b98\u529f\u80fd\uff09\u4f5c\u70ba\u5171\u8b8a\u6578\u88ab\u6536\u96c6\uff0c\u4ee5\u544a\u77e5\u6a21\u578b\u4e26\u8a2d\u8a08\u521d\u59cb\u8d77\u59cb\u5291\u91cf\u3002Moes\u91ab\u5e2b\u5c07\u9019\u4e00\u95dc\u9375\u7684\u7b2c\u4e00\u6b65\u7a31\u70ba\u300c\u65e9\u671f\u5291\u91cf\u9069\u61c9\u300d[2]\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u78ba\u8a8d\u8207\u7cbe\u7149 :<\/b><span style=\"font-weight: 400;\"> \u70ba\u4e86\u63a7\u5236\u60a3\u8005\u9593\u7684\u9ad8\u5ea6\u8b8a\u7570\u6027\uff0c\u6703\u4f7f\u7528\u89c0\u6e2c\u6578\u64da\u3002(\u4f8b\u5982\u85e5\u7269\u6fc3\u5ea6\u91cf\u6e2c\u8207\u85e5\u6548\u5b78\u751f\u7269\u6a19\u8a18 ) \u4f5c\u70ba\u8c9d\u6c0f\u53cd\u994b\u7528\u65bc\u66f4\u65b0\u6a21\u578b\uff0c\u4f7f\u5176\u53cd\u6620\u60a3\u8005\u7684\u5be6\u969b\u85e5\u7269\u8655\u7406\u7279\u6027\u8207\u8868\u578b\u3002 [2] \u6b64\u8fed\u4ee3\u904e\u7a0b\u5141\u8a31\u751f\u7269\u6a19\u8a18\u7269\u6536\u96c6\u5f8c\u9032\u884c\u5fc5\u8981\u7684\u5291\u91cf\u7cbe\u7149\uff0c\u9019\u5728\u8840\u6db2\u816b\u7624\u5b78\u7ba1\u7406\u66f4\u8907\u96dc\u85e5\u7269\u5982\u751f\u7269\u88fd\u5291\u6642\u5c24\u70ba\u95dc\u9375\uff0cMoes\u91ab\u5e2b\u5f37\u8abf\u5c0d\u96e3\u6cbb\u6027\u60a3\u8005\u7fa4\u9ad4\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\u81f3\u95dc\u91cd\u8981\u3002 [2]<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">\u6709\u6548\u904b\u7528MIPD\u7684\u95dc\u9375\u8981\u7d20\u56e0\u6b64\u9700\u8981\u7a69\u5065\u7684\u81e8\u5e8a\u57fa\u790e\u8a2d\u65bd\u8207\u53ef\u9760\u7684\u5be6\u9a57\u5ba4\u6aa2\u9a57 <\/span><span style=\"font-weight: 400;\">\u6db2\u76f8\u5c64\u6790-\u8cea\u8b5c\u6cd5\u7528\u65bc\u591a\u91cd\u6297\u9ad4\u6aa2\u6e2c), \u4ee5\u53ca\u95dc\u9375\u6027\u5730\u5c07\u96fb\u5b50\u5065\u5eb7\u7d00\u9304\uff08EHR\uff09\u8207\u5be6\u9a57\u5ba4\u8cc7\u8a0a\u7cfb\u7d71\uff08LIS\uff09\u76f4\u63a5\u6574\u5408\u81f3\u5291\u91cf\u5de5\u5177\u3002 [1].\u5f8c\u8005\u7684\u4e00\u500b\u4f8b\u9805\u662f\u540d\u70baRoadMAB\u7684\u7a0b\u5f0f\uff0c\u9019\u662f\u7531Mizuno\u91ab\u5e2b\u548c\u4ed6\u7684\u5718\u968a\u5728\u8f9b\u8f9b\u90a3\u63d0\u5152\u7ae5\u91ab\u9662\u91ab\u7642\u4e2d\u5fc3(CCHMC)\u958b\u767c\u7684\u624b\u8853\u7d66\u85e5\u8edf\u9ad4[3\uff0c4]\u3002<\/span> <span style=\"font-weight: 400;\">\u8a72\u5de5\u5177\u5c08\u9580\u8a2d\u8a08\u70ba\u6574\u5408\u5230EHR\u4e2d\uff0c\u4ee5\u81ea\u52d5\u6821\u6b63\u5fc5\u8981\u7684\u60a3\u8005\u8cc7\u6599\u9032\u884c\u5206\u6790\uff0c\u6709\u6548\u95dc\u9589\u8cc7\u6599\u3001\u8a3a\u65b7\u548c\u6c7a\u7b56\u4e4b\u9593\u7684\u6578\u4f4d\u5faa\u74b0\u3002\u00a0\u00a0<\/span><\/p>\n<h2 style=\"font-family: Inter !important; font-weight: 500 !important; font-size: 28px !important; line-height: 36px !important; letter-spacing: 0px !important;\">\u771f\u5be6\u4e16\u754c\u8cc7\u6599(RWD)\u8207\u5927\u8cc7\u6599\u5206\u6790\u7684\u5a01\u529b<\/h2>\n<p><span style=\"font-weight: 400;\">\u96d6\u7136MIPD\u70ba\u500b\u9ad4\u5316\u7d66\u85e5\u63d0\u4f9b\u4e86\u95dc\u9375\u7684\u5b9a\u91cf\u67b6\u69cb\uff0c\u4f46\u7576\u85c9\u7531\u771f\u5be6\u4e16\u754c\u8b49\u64da\u4e0d\u65b7\u5b8c\u5584\u5176\u9810\u6e2c\u6a21\u578b\u6642\uff0c\u6b64\u6578\u4f4d\u65b9\u6cd5\u7684\u771f\u6b63\u529b\u91cf\u5f97\u4ee5\u5be6\u73fe\u3002\u9019\u5c31\u662fRWD\u548c\u5927\u8cc7\u6599\u5206\u6790\u6210\u70ba\u63a8\u9032TDM\u548c\u81e8\u5e8a\u6bd2\u7406\u5b78\u4e0d\u53ef\u6216\u7f3a\u7684\u5de5\u5177\u7684\u5730\u65b9[5]\u3002\u00a0<\/span> <span style=\"font-weight: 400;\">RWD\u7684\u5f37\u5ea6\u5728\u65bc\u5176\u5ee3\u6cdb\u7684\u96c6\u5408\u3002RWD\u6e90\u81ea\u81ea\u767c\u5831\u544a\u8cc7\u6599\u5eab\u3001\u7d22\u8ce0\u8cc7\u6599\u5eab\u548cEHR\uff0c\u70ba\u6aa2\u6e2c\u4e0d\u826f\u4e8b\u4ef6\u548c\u8a55\u4f30\u7576\u524d\u81e8\u5e8a\u5be6\u8e10\u6a21\u5f0f\u63d0\u4f9b\u81f3\u95dc\u91cd\u8981\u7684\u88dc\u5145\u898b\u89e3[6]\u3002\u6b64\u9f90\u5927\u3001\u8907\u96dc\u7684\u8cc7\u6599\u96c6\u5c0d\u5047\u8a2d\u7522\u751f\u81f3\u95dc\u91cd\u8981\uff1a\u5927\u578b\u89c0\u5bdf\u6027RWD\u96c6-\u4f8b\u5982Legg\u535a\u58eb[5]\u5f15\u7528\u7684\u91dd\u5c0d\u03b2-\u5167\u91af\u80fa\u985e TDM\u7684BLUeY\u767b\u8a18\u8868-\u5141\u8a31ML\u8fa8\u8b58\u7531\u65bc\u7f55\u898b\u7d50\u679c\u6216\u8907\u96dc\u7684\u60a3\u8005\u53ef\u8b8a\u6027\u800c\u5728\u8f03\u5c0f\u3001\u50b3\u7d71\u7814\u7a76\u4e2d\u7d93\u5e38\u907a\u6f0f\u7684\u65e9\u671f\u5047\u8a2d\u7522\u751f\u8a0a\u865f[8]\u3002\u00a0<\/span> <span style=\"font-weight: 400;\">\u66f4\u91cd\u8981\u7684\u662f\uff0c\u8a72\u8cc7\u6599\u76f4\u63a5\u8f49\u5316\u70ba\u53ef\u8b49\u660e\u7684\u81e8\u5e8a\u5f71\u97ff\u3002\u4f8b\u5982\uff0c\u5c0d\u7d22\u8ce0\u8cc7\u6599\u7684\u5206\u6790\u8868\u660e\uff0c\u4e00\u81f4\u7684\u96a8\u8a2aTDM\u53ef\u986f\u8457\u964d\u4f4e\u85e5\u7269\u8a98\u767c\u6bd2\u6027\u7684\u767c\u751f\u7387\uff0c\u4e00\u9805\u7814\u7a76\u6307\u51fa\uff0c\u9019\u7a2e\u65b9\u6cd5\u5c07\u842c\u53e4\u9ef4\u7d20\u8a98\u767c\u7684\u814e\u6bd2\u6027\u767c\u751f\u7387\u5f9e60.9%\u964d\u4f4e\u52309.9%\uff0c\u5c71\u7530\u91ab\u5e2b\u5206\u4eab\u4e86\u9019\u4e00\u7d50\u679c[6]\u3002\u00a0<\/span><\/p>\n<h2 style=\"font-family: Inter !important; font-weight: 500 !important; font-size: 28px !important; line-height: 36px !important; letter-spacing: 0px !important;\">\u7528\u65bc\u4e0b\u4e00\u4ee3\u6c7a\u7b56\u652f\u63f4\u7684AI\u53ca\u6a5f\u5668\u5b78\u7fd2(ML)<\/h2>\n<p><span style=\"font-weight: 400;\">\u4f7f\u7528RWD\u751f\u6210\u5047\u8a2d\u53ca\u9a57\u8b49\u5be6\u8e10\u6a21\u5f0f\u7684\u80fd\u529b\u5c0d\u80fd\u5920\u8655\u7406\u6b64\u985e\u5927\u91cf\u3001\u8907\u96dc\u8cc7\u6599\u96c6\u7684\u8907\u96dc\u5206\u6790\u5de5\u5177\u7522\u751f\u91cd\u8981\u9700\u6c42\u3002\u8a3a\u65b7\u5be6\u9a57\u5ba4\u53ca\u81e8\u5e8a\u5718\u968a\u85c9\u7531AI\u53caML\u4e4b\u5148\u9032\u8a08\u7b97\u80fd\u529b\uff0c\u53ef\u5c07\u5927\u91cf\u8cc7\u6599\u8f49\u5316\u70ba\u53ef\u9810\u6e2c\u3001\u53ef\u64cd\u4f5c\u53ca\u500b\u4eba\u5316\u4e4b\u7d66\u85e5\u898b\u89e3\u3002<\/span><\/p>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u52d5\u614b\u5efa\u6a21\uff1a<\/b><span style=\"font-weight: 400;\"> AI\u5c0d\u65bc\u8655\u7406\u958b\u767c\u66f4\u8907\u96dc\u53ca\u52d5\u614b\u7fa4\u9ad4PK (PopPK)\u6a21\u578b\u6240\u9700\u4e4b\u5927\u6a23\u54c1\u91cf\u53ca\u6df7\u96dc\u8b8a\u6578\u81f3\u95dc\u91cd\u8981\uff0c\u8a72\u7b49\u6a21\u578b\u53ef\u9069\u61c9\u60a3\u8005\u96a8\u6642\u9593\u63a8\u79fb\u4e4b\u8b8a\u5316\u7684\u81e8\u5e8a\u5f15\u6578\uff0c\u5982Legg\u535a\u58eb\u6240\u5f37\u8abf[8]\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u6df7\u5408\u6a21\u578b<\/b><span style=\"font-weight: 400;\">\uff1aMizuno\u535a\u58eb\u4ea6\u5f37\u8abf\uff0c\u6700\u5177\u524d\u666f\u7684\u65b9\u6cd5\u8d85\u8d8a\u5b64\u7acb\u6280\u8853\u3002\u6b64\u6d89\u53ca\u5c07\u7fd2\u7528\u8c9d\u6c0f\u4f30\u8a08\u4e4b\u81e8\u5e8a\u5408\u7406\u6027\u8207ML \uff08\u4f8b\u5982\uff0c\u4f7f\u7528XGBoost\u6a21\u578b\uff09\u7d44\u5408\u4ee5\u6821\u6b63\u9810\u6e2c\u8aa4\u5dee\u3002\u9019\u5c0e\u81f4\u7a69\u5065\u7684\u6df7\u5408\u6a21\u578b\u6301\u7e8c\u512a\u65bc\u5e38\u898fPopPK\u65b9\u6cd5[3]\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u81ea\u52d5\u5316\u53ca\u667a\u6167AI\uff1a<\/b><span style=\"font-weight: 400;\">\u5c55\u671b\u672a\u4f86\uff0c\u672a\u4f86\u7684\u7cfb\u7d71\u6b63\u5728\u4f7f\u7528\u5f37\u5316\u5b78\u7fd2\u4f86\u5efa\u7acbAI\u85e5\u5291\uff0c\u8a72\u7b49\u85e5\u5291\u53ef\u81ea\u52d5\u6536\u96c6\u60a3\u8005\u8cc7\u6599\u3001\u8a55\u5b9a\u6cbb\u7642\u9078\u9805\u4ee5\u53ca\u5efa\u8b70\u7d66\u85e5\u65b9\u6848\u53ca\u9593\u9694\u3002Mizuno\u535a\u58eb\u4ea6\u5f37\u8abf\uff0c\u6b64\u9032\u6b65\u53ef\u7c21\u5316\u6574\u500b\u7d66\u85e5\u904e\u7a0b\uff0c\u4e26\u63d0\u5347\u4eba\u985e\u6c7a\u7b56[3]\u3002<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2 style=\"font-family: Inter !important; font-weight: 500 !important; font-size: 28px !important; line-height: 36px !important; letter-spacing: 0px !important;\">\u8a3a\u65b7\u9818\u5c0e\u5c64\u7684\u7b56\u7565\u50f9\u503c\u8207\u6295\u8cc7\u5831\u916c(ROI)<\/h2>\n<p><span style=\"font-weight: 400;\">\u7e3d\u800c\u8a00\u4e4b\uff0cMIPD\u67b6\u69cb\u3001RWD\u53ca\u9810\u6e2cAI\u4e4b\u6574\u5408\u4e0d\u50c5\u50c5\u662f\u4e00\u500b\u5b78\u8853\u6982\u5ff5\uff1b\u5b83\u4ee3\u8868\u4e86\u8a3a\u65b7\u5b78\u50f9\u503c\u4e3b\u5f35\u4e4b\u6839\u672c\u8f49\u8b8a\u3002\u5c0d\u65bc\u5be6\u9a57\u5ba4\u548c\u91ab\u9662\u7684\u9818\u5c0e\u529b\uff0c\u9019\u7a2e\u878d\u5408\u76f4\u63a5\u8f49\u5316\u70ba\u53ef\u91cf\u5316\u7684\u6548\u76ca\uff0c\u5c0d\u60a3\u8005\u6536\u5165\u548c\u7d44\u7e54\u76c8\u5229\u5747\u6709\u5f71\u97ff\u3002<\/span><\/p>\n<h3 style=\"font-family: Inter !important; font-weight: 500 !important; font-size: 24px !important; line-height: 32px !important; letter-spacing: 0px !important;\">A)\u589e\u5f37\u75c5\u60a3\u5b89\u5168\u6027\u548c\u81e8\u5e8a\u7d50<\/h3>\n<p><span style=\"font-weight: 400;\">\u679c\u6578\u4f4d\u8f49\u578b\u7684\u4e3b\u8981\u76ca\u8655\u662f\u5b83\u80fd\u5920\u5c07\u8a3a\u65b7\u670d\u52d9\u5f9e\u88ab\u52d5\u5831\u544a\u63d0\u5347\u70ba\u4e3b\u52d5\u3001\u500b\u4eba\u5316\u7684\u6307\u5c0e\uff0c\u5f9e\u800c\u63d0\u4f9b\u66f4\u597d\u7684\u75c5\u60a3\u7167\u8b77\uff1a<\/span><\/p>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u7cbe\u78ba\u5ea6\u53ca\u6e96\u78ba\u5ea6\uff1a<\/b><span style=\"font-weight: 400;\"> AI\u6f14\u6f14\u7b97\u6cd5\u63d0\u4f9b\u5148\u524d\u7121\u6cd5\u9054\u5230\u7684\u9810\u6e2c\u80fd\u529b\u6c34\u6e96\u3002\u8209\u4f8b\u800c\u8a00\uff0cAI\u5de5\u5177\u5df2\u5c55\u793a\u9810\u6e2c\u95dc\u9375\u81e8\u5e8a\u503c(\u8af8\u5982\u83ef\u6cd5\u6797\u4e4b\u7b2c\u4e94\u5929\u570b\u969b\u6a19\u6e96\u5316\u6bd4(INR))\u4e4b\u80fd\u529b\uff0c\u5176\u6e96\u78ba\u5ea6\u53ef\u8207\u4eba\u985e\u5c08\u5bb6\u76f8\u5339\u914d\u6216\u7565\u52dd\u4eba\u985e\u5c08\u5bb6[8]\u3002\u6b64\u9810\u6e2c\u80fd\u529b\u4f7f\u6700\u4f73\u6cbb\u7642\u4e4b\u5371\u96aa\u5ef6\u9072\u6700\u5c0f\u5316\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u4e3b\u52d5\u5e72\u9810\uff1a<\/b><span style=\"font-weight: 400;\">\u85c9\u7531\u5c07\u9810\u6e2c\u6a21\u578b\u8207\u81e8\u5e8a\u5de5\u4f5c\u6d41\u7a0b\u95dc\u806f\uff0c\u6578\u4f4d\u6c7a\u7b56\u652f\u63f4\u5100\u8868\u677f\u4f7f\u81e8\u5e8a\u91ab\u5e2b\u80fd\u5920\u7acb\u5373\u63a5\u6536\u7531PK\u5f15\u5c0e\u4e4b\u5291\u91cf\u5efa\u8b70\u3002Mizuno\u91ab\u5e2b\u8868\u793a\uff0c\u9019\u6709\u52a9\u65bc\u4e3b\u52d5\u5e72\u9810\uff0c\u900f\u904e\u78ba\u4fdd\u60a3\u8005\u66f4\u5feb\u9054\u6210\u4e26\u7dad\u6301\u6a19\u9776\u6cbb\u7642\uff0c\u5f9e\u800c\u964d\u4f4e\u767c\u751f\u7387\u548c\u4f4f\u9662\u6642\u9593\uff0c\u9032\u800c\u652f\u63f4\u66f4\u597d\u7684\u6cbb\u7642\u7d50\u679c[3]\u3002\u00a0<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h3 style=\"font-family: Inter !important; font-weight: 500 !important; font-size: 24px !important; line-height: 32px !important; letter-spacing: 0px !important;\">B)\u71df\u904b\u6548\u7387\u53ca\u8ca1\u52d9\u6bd2\u6027<\/h3>\n<p><span style=\"font-weight: 400;\">\u964d\u4f4e\u6578\u4f4dTDM\u4f5c\u70ba\u6210\u672c\u63a7\u5236\u7684\u5f37\u5927\u69d3\u687f\uff0c\u5c24\u5176\u5c0d\u65bc\u6602\u8cb4\u7684\u7279\u7a2e\u85e5\u7269\uff0c\u5c07\u85e5\u7269\u76e3\u6e2c\u8f49\u5316\u70ba\u6709\u5f62\u8ca1\u52d9\u56de\u5831\u7684\u4f86\u6e90\uff1a<\/span><\/p>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u6210\u672c\u63a7\u5236\uff1a<\/b><span style=\"font-weight: 400;\">\u6700\u4f73\u5316\u7d66\u85e5\u53ef\u85c9\u7531\u6700\u5927\u9650\u5ea6\u6e1b\u5c11\u85e5\u7269\u6d6a\u8cbb\u53ca\u66dd\u9732\u91cf\uff0c\u76f4\u63a5\u89e3\u6c7a\u6602\u8cb4\u7642\u6cd5\u7684\u9ad8\u6210\u672c\u3002\u85c9\u7531\u78ba\u4fdd\u6bcf\u5291\u5291\u91cf\u5118\u53ef\u80fd\u7cbe\u78ba\uff0c\u91ab\u9662\u53ef\u4ee5\u986f\u8457\u7de9\u89e3\u8207\u9032\u968e\u6cbb\u7642\u76f8\u95dc\u7684\u8ca1\u52d9\u6bd2\u6027\u9019\u4e00\u65e5\u76ca\u56b4\u5cfb\u7684\u6311\u6230[2]\u3002\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u53ef\u91cf\u5316\u7684ROI\uff1a<\/b><span style=\"font-weight: 400;\">\u7b56\u7565\u6027\u5730\u4f7f\u7528PK\/PD\u6a21\u578b\u53ca<\/span><i><span style=\"font-weight: 400;\">\u96fb\u8166\u6a21\u64ec<\/span><\/i><span style=\"font-weight: 400;\">\u7684\u5291\u91cf\u8abf\u6574\u5df2\u5be6\u73fe\u986f\u8457\u7684\u3001\u53ef\u6e2c\u91cf\u7684\u6210\u672c\u7bc0\u7701\uff1a<\/span>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><b>\u85e5\u7269\u6d6a\u8cbb\u6e1b\u5c11\uff1a<\/b><span style=\"font-weight: 400;\">\u5728\u67d0\u4e9b\u6297\u9ad4-\u85e5\u7269\u7d50\u5408\u7269(ADC)\u7684\u5291\u91cf\u8abf\u6574\u4e2d\uff0c\u65e8\u5728\u50c5\u4f7f\u7528\u6574\u500b\u85e5\u7269\u5c0f\u74f6\u7684\u7b56\u7565\u5c0e\u81f4\u85e5\u7269\u8cbb\u7528\u4f30\u8a08\u6e1b\u5c1125% [2]\u3002\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><b>\u5ef6\u9577\u9593\u9694\uff1a<\/b><span style=\"font-weight: 400;\">\u5728Moes\u535a\u58eb\u7684\u540c\u4e00\u6f14\u793a\u4e2d\uff0c\u6a21\u578b\u57fa\u65bc\u6a21\u578b\u7684\u5291\u91cf\u8abf\u6574\u6700\u4f73\u5316\u4ea6\u53ef\u540c\u6642\u63d0\u9ad8\u60a3\u8005\u4fbf\u5229\u6027\u4e26\u964d\u4f4e\u6210\u672c\u3002\u958b\u767c\u76ae\u4e0b\u514d\u75ab\u67e5\u6838\u9ede\u963b\u65b7\u5291\uff08\u4f8b\u5982\uff0c\u7d0d\u6b66\u5229\u5c24\u55ae\u6297\uff09\u7684\u9ad4\u91cd\u4f9d\u8cf4\u6027\u7d66\u85e5\u9593\u9694\u5df2\u88ab\u8b49\u660e\u53ef\u7bc0\u770130%\u4ee5\u4e0a\u7684\u5e74\u5ea6\u85e5\u7269\u8cbb\u7528\uff0c\u540c\u6642\u4fdd\u6301\u56b4\u683c\u7684\u81e8\u5e8a\u7642\u6548\u6a19\u6e96[2]\u3002<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h3 style=\"font-family: Inter !important; font-weight: 500 !important; font-size: 24px !important; line-height: 32px !important; letter-spacing: 0px !important;\">C)\u8a3a\u65b7\u9023\u7e8c\u9ad4<\/h3>\n<p><span style=\"font-weight: 400;\">\u6578\u4f4d\u8f49\u578b\u5f9e\u6839\u672c\u4e0a\u6539\u8b8a\u4e86\u5be6\u9a57\u5ba4\u5728\u7167\u8b77\u9023\u7e8c\u9ad4\u4e2d\u7684\u5730\u4f4d-\u5b83\u4e0d\u518d\u662f\u670d\u52d9\u63d0\u4f9b\u5546\uff0c\u800c\u662f\u6cbb\u7642\u9818\u57df\u7684\u6230\u7565\u5408\u4f5c\u5925\u4f34\uff1a<\/span><\/p>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>EHR\u6574\u5408\uff1a<\/b><span style=\"font-weight: 400;\">\u958b\u767c\u50cfRoadMAB\u8edf\u9ad4\u9019\u6a23\u7684\u5de5\u5177\uff0c\u5c07MIPD\u548cML\u76f4\u63a5\u6574\u5408\u5230EHR\u4e2d\uff0c\u53ef\u81ea\u52d5\u5316\u7cfe\u6b63\u5fc5\u8981\u7684\u60a3\u8005\u8cc7\u6599\uff0c\u4e26\u7c21\u5316\u81e8\u5e8a\u91ab\u5e2b\u7684\u5206\u6790[3\uff0c4]\u3002\u9019\u9805\u5275\u65b0\u5c07\u8a3a\u65b7\u50f9\u503c\u4e3b\u5f35\u5f9e\u975c\u614b\u5be6\u9a57\u5ba4\u7d50\u679c\u8f49\u8b8a\u70ba\u6700\u7d42\u7684\u53ef\u64cd\u4f5c\u7642\u6cd5\u5efa\u8b70\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u65b0\u6e2c\u5b9a\u53ca\u591a\u91cd\u6e2c\u5b9a\uff1a<\/b><span style=\"font-weight: 400;\">\u5c0d\u4e0b\u4e00\u4ee3\u6e2c\u5b9a\u7684\u6230\u7565\u6295\u8cc7\uff0c\u8af8\u5982Moes\u535a\u58eb\u6240\u6307\u51fa\u7684LCMS\uff0c\u4f7f\u5f97\u80fd\u5920\u5728\u55ae\u500b\u60a3\u8005\u6a23\u54c1\u4e2d\u540c\u6642\u6e2c\u91cf\u591a\u7a2e\u85e5\u7269\u6fc3\u5ea6\u6216\u6297\u9ad4[2]\u3002\u9019\u589e\u5f37\u4e86\u5be6\u9a57\u5ba4\u7684\u670d\u52d9\u7d44\u5408\uff0c\u63d0\u9ad8\u4e86\u6548\u7387\uff0c\u4e26\u652f\u63f4\u4e86\u751f\u7269\u88fd\u5291\u76e3\u6e2c\u7684\u8907\u96dc\u9700\u6c42\u3002\u00a0<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">\u9019\u4e9b\u5be6\u73fe\u7684\u9ad8\u6548\u7387\u51f8\u986f\u4e86\u95dc\u9375\u7684\u6b63\u898f\u5316\u8f49\u8b8a\uff1aTDM\u7684\u6578\u4f4d\u8f49\u578b\u662f\u50f9\u503c\u5275\u9020\u5668\uff0c\u5e36\u4f86\u53ef\u8fa8\u5225\u4e14\u53ef\u89c0\u7684\u6295\u8cc7\u56de\u5831(ROI)\uff0c\u800c\u4e0d\u50c5\u50c5\u662f\u7522\u751f\u9593\u63a5\u6210\u672c\u3002<\/span><\/p>\n<h2 style=\"font-family: Inter !important; font-weight: 500 !important; font-size: 28px !important; line-height: 36px !important; letter-spacing: 0px !important;\">\u8f49\u578b\u85cd\u5716\uff1a\u547c\u7c72\u9818\u5c0e\u529b<\/h2>\n<p><span style=\"font-weight: 400;\">\u8981\u5be6\u73fe\u5982\u6b64\u91cd\u5927\u7684\u6295\u8cc7\u5831\u916c\u7387\uff0c\u4e26\u7dad\u6301\u5148\u9032\u7684\u8a3a\u65b7\u9023\u7e8c\u9ad4\u7cfb\uff0c\u5c31\u9700\u8981\u6df1\u601d\u719f\u616e\u7684\u524d\u77bb\u6027\u7b56\u7565\uff0c\u89e3\u6c7a\u7d44\u7e54\u6e96\u5099\u7a0b\u5ea6\u548c\u6280\u8853\u7ba1\u7406\u7684\u554f\u984c\u3002\u5c0d\u65bc\u5be6\u9a57\u5ba4\u548c\u91ab\u9662\u7684\u9818\u5c0e\u8005\u4f86\u8aaa\uff0c\u524d\u9032\u7684\u9053\u8def\u4e0d\u50c5\u5728\u65bc\u63a1\u7528\u6280\u8853\uff0c\u9084\u5728\u65bc\u63a8\u52d5\u6a5f\u69cb\u8b8a\u9769\u3002\u70ba\u5be6\u73fe\u9019\u4e00\u76ee\u6a19\uff0c\u5fc5\u9808\u63a1\u53d6\u4e00\u7cfb\u5217\u660e\u78ba\u7684\u884c\u52d5\uff1a<\/span><\/p>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u8de8\u90e8\u9580\u5408\u4f5c\uff1a<\/b><span style=\"font-weight: 400;\">\u5be6\u73fe\u6574\u5408\u7167\u8b77\u7684\u6574\u9ad4\u9858\u666f\u9700\u8981\u6253\u7834\u50b3\u7d71\u7684\u5b64\u5cf6\u3002\u70ba\u78ba\u4fdd\u7121\u7e2b\u7684\u5de5\u5177\u6574\u5408\u53ca\u5de5\u4f5c\u6d41\u7a0b\u63a1\u7d0d\uff0c\u5305\u62ec\u81e8\u5e8a\u85e5\u5c40\u3001\u5be6\u9a57\u5ba4\u670d\u52d9\u3001IT\/\u8edf\u9ad4\u958b\u767c\u548c\u91ab\u9662\u7ba1\u7406\u7b49\u95dc\u9375\u5229\u5bb3\u95dc\u4fc2\u4eba\u4e4b\u9593\u5fc5\u9808\u6709\u6548\u5408\u4f5c[1]\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u6cbb\u7406\u548c\u54c1\u8cea\u63a7\u5236\uff1a<\/b><span style=\"font-weight: 400;\">\u6578\u4f4d\u6280\u8853\uff0c\u5c24\u5176\u662fAI\uff0c\u9700\u8981\u8b39\u614e\u7ba1\u7406\u3002\u9818\u5c0e\u5c64\u5fc5\u9808\u512a\u5148\u8003\u616e\u7a69\u5065\u7684\u8cc7\u6599\u54c1\u8cea\u3001\u56b4\u683c\u7684\u5916\u90e8\u9a57\u8b49\u548c\u5f37\u5927\u7684\u6cbb\u7406\uff0c\u4ee5\u78ba\u4fdd\u6a21\u578b\uff08\u5c24\u5176\u662f\u5229\u7528RWD\u7684\u6a21\u578b\uff09\u5c0d\u65bc\u5ee3\u6cdb\u7684\u75c5\u60a3\u7167\u8b77\u662f\u5b89\u5168\u4e14\u503c\u5f97\u4fe1\u8cf4\u7684[8]\u3002\u5236\u5b9a\u660e\u78ba\u7684\u65b9\u6848\u53ef\u9632\u7bc4\u8cac\u4efb\u4e26\u78ba\u4fdd\u60a3\u8005\u5b89\u5168\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u6295\u8cc7\u91cd\u9ede\uff1a<\/b><span style=\"font-weight: 400;\">\u672a\u4f86\u7684\u6295\u8cc7\u91cd\u9ede\u61c9\u8a72\u662f\u6574\u5408\u7cfb\u7d71\uff0c\u800c\u4e0d\u662f\u8cfc\u8cb7\u5b64\u7acb\u7684\u5de5\u5177\u3002\u9019\u5305\u62ec\u5c07\u5b8c\u6574\u85e5\u6548\u5b78\uff08PK\/PD\u6a21\u578b\uff09\u3001\u6578\u4f4d\u5b7f\u751f\u7b49\u9ad8\u7d1a\u6982\u5ff5\u53ca\u5b8c\u5584\u7684AI\u529f\u80fd\u76f4\u63a5\u6574\u5408\u5230\u81e8\u5e8a\u6c7a\u7b56\u652f\u63f4\u5100\u8868\u677f\u4e2d\u3002\u9019\u7a2e\u65b9\u6cd5\u5c07\u9032\u4e00\u6b65\u73fe\u4ee3\u5316\u548c\u8f49\u8b8aTDM\uff0c\u78ba\u4fdd\u6700\u7d42\u76ee\u6a19\uff1a<\/span><b><i>\u5728\u6b63\u78ba\u6642\u9593\u3001\u70ba\u6bcf\u4f4d\u75c5\u60a3\u63d0\u4f9b\u6b63\u78ba\u7684\u85e5\u7269\u3001\u6b63\u78ba\u7684\u5291\u91cf<\/i><\/b><span style=\"font-weight: 400;\"> [2\uff0c3]\u3002<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">\u6700\u7d42\uff0cTDM\u7684\u6578\u4f4d\u672a\u4f86\u2014\u6b63\u5982\u9019\u4e9b\u696d\u754c\u9818\u5c0e\u8005\u6240\u78ba\u8a8d\u7684\u2014\u5728\u65bc\u6709\u76ee\u7684\u7684\u7cbe\u78ba\u5ea6\u3002\u9019\u662f\u8a3a\u65b7\u90e8\u9580\u6210\u70ba\u7a4d\u6975\u3001\u6574\u5408\u7684\u7167\u8b77\u5408\u4f5c\u5925\u4f34\u7684\u6a5f\u6703\u3002\u6b64\u8f49\u578b\u70ba\u9818\u5c0e\u8005\u5e36\u4f86\u660e\u986f\u7684\u7af6\u722d\u512a\u52e2\u53ca\u53ef\u8861\u91cf\u7684\u56de\u5831\uff0c\u4f46\u771f\u6b63\u7684\u52dd\u5229\u5728\u65bc\u6709\u80fd\u529b\u900f\u904e\u5c07\u500b\u4eba\u5316\u5b89\u5168\u4f5c\u70ba\u6bcf\u500b\u4eba\u7684\u6838\u5fc3\u6a19\u6e96\uff0c\u5f9e\u6839\u672c\u4e0a\u63d0\u5347\u4eba\u985e\u7684\u91ab\u7642\u9ad4\u9a57\u3002<\/span><\/p>\n<hr \/>\n<p><i><span style=\"font-weight: 400;\">\u53c3\u8003\u6587\u737b<\/span><\/i><\/p>\n<p><a href=\"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bcp.14426\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[1] <\/span><\/a><span style=\"font-weight: 400;\">Mizuno\uff0cT.\u3001Vinks\uff0cA.A.\u3001Fukuda\uff0cT.\u3001Rosenheck\uff0cR.\u3001Wetterland\uff0cL.\u3001de Leon\uff0cJ.\u3001Hartman\uff0cS.\u3001Arnold\uff0cL.M.\u53caPatino\uff0cL.R. (2022) \u300c\u85e5\u7269\u907a\u50b3\u5b78\u8207\u6a21\u578b\u544a\u77e5\u7cbe\u6e96\u5291\u91cf\u4e4b\u81e8\u5e8a\u61c9\u7528\u4ee5\u6539\u5584\u75c5\u4eba\u7167\u8b77\u300d\uff0c<\/span><i><span style=\"font-weight: 400;\">British Journal of Clinical Pharmacology<\/span><\/i> <a href=\"https:\/\/docs.google.com\/document\/d\/1BvNl8lAYxfy36xmXXwKktXdTbsklaISkKwx1QEqg9no\/edit?usp=drive_link\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">\uff0c88(4)\uff0c\u7b2c1418-1426\u9801<\/span><\/a><\/p>\n<p><a href=\"https:\/\/docs.google.com\/document\/d\/1BvNl8lAYxfy36xmXXwKktXdTbsklaISkKwx1QEqg9no\/edit?usp=drive_link\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[2]<\/span><\/a><span style=\"font-weight: 400;\"> Moes\uff0cD.J. (2025) \u300cModel Informed (precision) dosing of biologics in (hemato)oncology\uff1achallenges and opportunities\uff1f\u300d\uff0c<\/span><i><span style=\"font-weight: 400;\">\u7b2c23\u5c46\u570b\u969b\u6cbb\u7642\u85e5\u7269\u76e3\u6e2c\u8207\u81e8\u5e8a\u6bd2\u7406\u5b78\u5b78\u6703\u5927\u6703(IATDMCT)\u6703\u8b70<\/span><\/i><span style=\"font-weight: 400;\">\u30029\u670821\u65e5\u81f324\u65e5\uff0c\u65b0\u52a0\u5761\u683c\u862d\u79d1\u7d22\u6069\u6c34\u6ff1\u98ef\u5e97\u3002<\/span><\/p>\n<p><a href=\"https:\/\/docs.google.com\/document\/d\/1Uit7t_CVMWfrXb8H3bizV4Oqs0B3xdEKcnCWdBsj1MQ\/edit?usp=drive_link\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[3]<\/span><\/a><span style=\"font-weight: 400;\"> \u7f8e\u6d25\u6fc3T\u3002(2025) \u300cLeveraging machine learning and Decision support dashboard to facilitate precision dosing in pediatric patient care\u300d\uff0c<\/span><i><span style=\"font-weight: 400;\">\u7b2c23\u5c46\u570b\u969b\u6cbb\u7642\u85e5\u7269\u76e3\u6e2c\u53ca\u81e8\u5e8a\u6bd2\u7406\u5b78\u5354\u6703(IATDMCT)\u6703\u8b70<\/span><\/i><span style=\"font-weight: 400;\">\u30029\u670821\u65e5\u81f324\u65e5\uff0c\u65b0\u52a0\u5761\u683c\u862d\u79d1\u7d22\u6069\u6d77\u6ff1\u98ef\u5e97\u3002<\/span><\/p>\n<p><a href=\"https:\/\/academic.oup.com\/ibdjournal\/article\/29\/8\/1342\/6839996?login=false\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[4] <\/span><\/a><span style=\"font-weight: 400;\">Colman\uff0cR.J.\uff0cXiong\uff0cY.\uff0cMizuno\uff0cT.\uff0cXie\uff0cC.\uff0cVinks\uff0cA.A.\uff0cHyams\uff0cJ.S.\uff0cDenson\uff0cL.A.\u53caMinar\uff0cP.(2023) \u300cModel-INFORMED Precision Dosing for Biologics Now Available at the Bedside\uff1aA Roadmap for Strategies and Considerations for Real-world Implementation\u300d\uff0c<\/span><i><span style=\"font-weight: 400;\">\u767c\u708e\u6027\u8178\u9053\u75be\u75c5<\/span><\/i><span style=\"font-weight: 400;\">\uff0c29(1)\uff0c\u7b2c119-127\u9801\u3002 doi\uff1a10.1093\/ibd\/izac063.<\/span><\/p>\n<p><a href=\"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/psp4.12745\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[5]<\/span><\/a><span style=\"font-weight: 400;\"> Maier\uff0cC.\uff0cHartung\uff0cN.\uff0cKloft\uff0cC.\uff0cHuisinga\uff0cW.\u9084\u6709\u4ea8\u5229\u5e0c\u3002(2021) \u300cA continued learning approach for model-INFORMED precision dosing\uff1aupdate models in clinical practice\u300d\uff0c<\/span><i><span style=\"font-weight: 400;\">CPT\uff1aPharmacometrics &amp; Systems Pharmacology<\/span><\/i><span style=\"font-weight: 400;\">\uff0c10(4)\uff0c\u7b2c311-321\u9801\u3002<\/span><\/p>\n<p><a href=\"https:\/\/docs.google.com\/document\/d\/14aw8je3yf181fa3pnVx8u0AWBQldlrt1yC4K3zV2Npg\/edit?usp=drive_link\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[6] <\/span><\/a><span style=\"font-weight: 400;\">\u5c71\u7530\u3002(2025) \u300c\u7528\u65bc\u63a8\u9032\u6cbb\u7642\u85e5\u7269\u76e3\u6e2c\u53ca\u81e8\u5e8a\u6bd2\u7406\u5b78\u7684\u771f\u5be6\u4e16\u754c\u5927\u8cc7\u6599\u898b\u89e3(Real-World Big Data Insights for Advancing Therapeutic Drug Monitoring and Clinical Toxicology)\u300d\uff0c<\/span><i><span style=\"font-weight: 400;\">\u7b2c23\u5c46\u570b\u969b\u6cbb\u7642\u85e5\u7269\u76e3\u6e2c\u53ca\u81e8\u5e8a\u6bd2\u7406\u5b78\u5354\u6703(IATDMCT)\u6703\u8b70<\/span><\/i><span style=\"font-weight: 400;\">\u30029\u670821\u65e5\u81f324\u65e5\uff0c\u65b0\u52a0\u5761\u683c\u862d\u79d1\u7d22\u6069\u6d77\u6ff1\u98ef\u5e97\u3002<\/span><\/p>\n<p><a href=\"https:\/\/academic.oup.com\/jac\/article\/78\/10\/2395\/7226352\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[7]<\/span><\/a><span style=\"font-weight: 400;\"> Pai Mangalore\uff0cR.\u3001Peel\uff0cT.N.\u3001Udy\uff0cA.A.\u53caPeleg\uff0cA.Y. (2023) \u300cThe clinical application of beta-lactam antibiotic therapeutic drug monitoring in the critical care setting\u300d\uff0cJournal of Antimicrobial Chemotherapy\uff0c78(10)\uff0c\u7b2c2395-2405\u9801\u3002 \u8acb\u9020\u8a2a\uff1a<\/span><a href=\"https:\/\/doi.org\/10.1093\/jac\/dkad223\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/doi.org\/10.1093\/jac\/dkad223<\/span><\/a><span style=\"font-weight: 400;\">\uff08\u5b58\u53d6\u65e5\u671f\uff1a2026\u5e741\u670826\u65e5\uff09\u3002<\/span><\/p>\n<p><a href=\"https:\/\/docs.google.com\/document\/d\/1XDRqjvduAq3dbnFsj_bxBKyy4p0-XekBPtOhiKOAP8o\/edit?usp=drive_link\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[8] <\/span><\/a><span style=\"font-weight: 400;\">Legg\uff0cA.(2025) \u300c\u6578\u4f4d\u6642\u4ee3\u7684TDM\u7814\u7a76\uff1f\u300d\uff0c<\/span><i><span style=\"font-weight: 400;\">\u7b2c23\u5c46\u570b\u969b\u6cbb\u7642\u85e5\u7269\u76e3\u6e2c\u8207\u81e8\u5e8a\u6bd2\u7406\u5b78\u5354\u6703(IATDMCT)\u6703\u8b70<\/span><\/i><span style=\"font-weight: 400;\">\u30029\u670821\u65e5\u81f324\u65e5\uff0c\u65b0\u52a0\u5761\u683c\u862d\u79d1\u7d22\u6069\u6d77\u6ff1\u98ef\u5e97\u3002<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5728\u6cbb\u7642\u65b9\u9762\uff0c\u81e8\u5e8a\u7684\u6838\u5fc3\u6311\u6230\u901a\u5e38\u53ef\u4ee5\u6b78\u7d0d\u70ba\u4e00\u500b\u95dc\u9375\u554f\u984c\uff1a\u591a\u5c11\u85e5\u7269\u3001\u6301\u7e8c\u591a\u4e45\uff1f \u6216\u8005\u904e\u65bc\u5197\u9577\uff0c\u8ffd\u6c42\u771f\u6b63\u500b\u4eba\u5316\u91ab\u7642\u7684\u9858\u666f\u4e00\u76f4\u53d7\u5230\u975c\u614b\u3001\u4e00\u5200\u5207\u7684\u7d66\u85e5\u65b9\u5f0f\u4ee5\u53ca\u904e\u6642\u7684\u85e5\u52d5\u5b78\uff08PK\uff09\u6a21\u578b\u7684\u9650\u5236\u2014\u2014\u9019\u662f\u4e00\u7a2e\u50f5\u5316\u7684\u7cfb\u7d71\uff0c\u7121\u6cd5\u9069\u61c9\u751f\u7269\u88fd\u5291\u7b49\u5148\u9032\u85e5\u7269\u548c\u65b0\u5f37\u6548\u5316\u5408\u7269\u7684\u9700\u6c42\u3002\u00a0 \u4f46\u662f\uff0c\u82e5\u80fd\u6539\u8b8a\u7522\u696d\u9762\u81e8\u7684\u6578\u4f4d\u5de5\u5177\uff0c\u80fd\u70ba\u60a8\u722d\u53d6\u66f4\u591a\u6642\u9593\u5462\uff1f 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\u6b64\u9858\u666f\u7684\u53ef\u884c\u6027\u5df2\u5728\u53bb\u5e74\u65bc\u65b0\u52a0\u5761\u8209\u884c\u7684\u7b2c23\u5c46\u570b\u969b\u6cbb\u7642\u85e5\u7269\u76e3\u6e2c\u8207\u81e8\u5e8a\u6bd2\u7406\u5b78\u5b78\u6703\u5e74\u6703\u4e0a\u5f97\u5230\u9a57\u8b49\u3002(IATDMCT)\u6703\u8b70\u7684\u4e3b\u8981\u4e3b\u984c\u4e4b\u4e00\u3002\u8a72\u6d3b\u52d5\u65bc9\u6708\u8209\u884c\uff0c\u7531\u696d\u754c\u9802\u5c16\u5c08\u5bb6\u53ca\u6230\u7565\u5148\u92d2\u7d44\u6210\uff0c\u7cbe\u6e96\u5c55\u793a\u9019\u4e9b\u5de5\u5177\u7684\u904b\u4f5c\u65b9\u5f0f\u3002\u00a0\u7cbe\u6e96\u5be6\u9a57\u5ba4\u6d1e\u5bdf\u5718\u968a\u63d0\u7149\u51fa\u95dc\u9375\u6d1e\u898b\uff0c\u9019\u4e9b\u6d1e\u898b\u6e90\u81ea\u56db\u5834\u5bcc\u6709\u6d1e\u5bdf\u529b\u7684\u6f14\u8b1b\uff0c\u5c55\u793a\u4e86\u6578\u4f4d\u5316\u6cbb\u7642\u85e5\u7269\u76e3\u6e2c\uff08TDM\uff09\u548c\u81e8\u5e8a\u6bd2\u7406\u5b78\u7684\u591a\u9762\u5411\u65b9\u6cd5\uff0c\u9a57\u8b49\u4e86\u5176\u5728\u9081\u5411\u500b\u4eba\u5316\u7167\u8b77\u4e2d\u7684\u95dc\u9375\u89d2\u8272\uff1aAmy Legg \u535a\u58eb\u63a2\u8a0e\u4e86\u4eba\u5de5\u667a\u6167\uff08AI\uff09\u548c\u5927\u6578\u64da\u5728\u91cd\u5851 TDM \u7814\u7a76\u4e2d\u7684\u7b56\u7565\u89d2\u8272\uff0c\u5f37\u8abf\u52d5\u614b\u9810\u6e2c\u6a21\u578b\u7684\u5fc5\u8981\u6027\u3002Lab Insights\u5718\u968a\u6ce8\u610f\u5230\u5f9e\u56db\u5834\u6df1\u5165\u7684\u6f14\u8b1b\u4e2d\u5f97\u51fa\u7684\u95dc\u9375\u898b\u89e3\uff0c\u9019\u4e9b\u6f14\u8b1b\u5c55\u793a\u4e86TDM\u548c\u81e8\u5e8a\u6bd2\u7406\u5b78\u6578\u4f4d\u5316\u7684\u591a\u5c64\u9762\u65b9\u6cd5\uff0c\u9a57\u8b49\u4e86\u5176\u5728\u9081\u5411\u500b\u4eba\u5316\u7167\u8b77\u4e2d\u7684\u4f5c\u7528\uff1a Amy Legg\u535a\u58eb\u63a2\u7d22\u4e86\u4eba\u5de5\u667a\u6167(AI)\u548c 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\u5c71\u7530\u670b\u4e4b\u535a\u58eb\u5c55\u793a\u4e86\u5982\u4f55\u5229\u7528\u5927\u91cf\u771f\u5be6\u4e16\u754c\u8cc7\u6599\u4f86\u6e90(RWD)\u63d0\u4f9b\u95dc\u9375\u7684\u5b89\u5168\u6027\u8a0a\u865f\u4e26\u63a8\u9032\u6bd2\u7406\u5b78\u548c\u85e5\u7269\u76e3\u6e2c\u7684\u81e8\u5e8a\u5be6\u8e10\u3002\u4f5c\u70ba\u9818\u5c0e\u85e5\u7269\u8b66\u6212\u5de5\u4f5c\u7684\u9996\u5e2d\u85e5\u5291\u5e2b\uff0c\u5c71\u7530\u535a\u58eb\u7684\u500b\u6848\u7814\u7a76-\u4f8b\u5982\u8a55\u4f30\u9054\u6258\u9ef4\u7d20-\u4ed6\u6c40\u985e\u85e5\u7269\u4e92\u52d5\u4f5c\u7528\uff0c\u4ee5\u53ca\u5f8c\u7e8cTDM\u8a55\u4f30\u4ee5\u964d\u4f4e\u842c\u53e4\u9ef4\u7d20\u6bd2\u6027\u2014\u2014\u8b49\u660e\u4e86RWD\u5206\u6790\u5c0d\u60a3\u8005\u7d50\u679c\u7684\u5be6\u8cea\u5f71\u97ff\u3002 Dirk Jan 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