Dr Andrea Kwa, Assistant Director of Pharmacy Research at Singapore General Hospital, addresses the pressing issue of multidrug-resistance (MDR) prevalent in regions like Southeast Asia, East Asia, and Oceania. To combat MDR, she proposes a surveillance-driven approach using Rapid Diagnostic Testing to guide targeted therapy and reduce antibiotic overuse. Additionally, Dr. Kwa explores alternative strategies for treating complex infections and highlights the potential of personalised, combination antibiotic therapy.