Listen to perspectives from Professor Tan Puay Hoon, Senior Consultant Histopathologist and Chairman of the Division of Pathology at Singapore General Hospital, as she discusses triple negative breast cancer from a pathologist’s standpoint. In this recent webinar supported by the Singapore Society of Oncology, Prof Tan highlights the WHO guidelines for evaluating tumour infiltrating lymphocytes and explains why PD-L1 testing is crucial for identifying potentially immunotherapy responsive patients.

Prof Tan notes that PD-L1 immunohistochemistry (IHC) staining is not without limitations and challenges. To address this, she shares about their study on multiplex immunofluorescence, where multiple PD-L1 clones on the same tissue section yielded comparable results with traditional IHC. Although not yet widely implemented, it is a promising candidate for future use.